EP2354729B1 - Dispositif de réglage de températures très basses - Google Patents

Dispositif de réglage de températures très basses Download PDF

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Publication number
EP2354729B1
EP2354729B1 EP11153066.3A EP11153066A EP2354729B1 EP 2354729 B1 EP2354729 B1 EP 2354729B1 EP 11153066 A EP11153066 A EP 11153066A EP 2354729 B1 EP2354729 B1 EP 2354729B1
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EP
European Patent Office
Prior art keywords
chamber
inlet
volume
lock chamber
cold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP11153066.3A
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German (de)
English (en)
Other versions
EP2354729A1 (fr
Inventor
Dirk Leuthold
Steffen Grasser
Erhard Hülsse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ASKION GmbH
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ASKION GmbH
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Filing date
Publication date
Application filed by ASKION GmbH filed Critical ASKION GmbH
Publication of EP2354729A1 publication Critical patent/EP2354729A1/fr
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Publication of EP2354729B1 publication Critical patent/EP2354729B1/fr
Not-in-force legal-status Critical Current
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00—General constructional features
    • F25D23/02—Doors; Covers
    • F25D23/028—Details

Definitions

  • the invention relates to a device for adjusting and maintaining cryogenic temperatures with at least one cold chamber and an energy-efficient and ice-free access to this, as they are generically in the DE 34 41 091 C2 is described.
  • Deep-freezing or cryogenic temperatures are usually generated by the action of cold and evaporating gases, whereby the endothermic volume increase of such gases is used for lowering the ambient temperature.
  • temperatures which are substantially lower than the temperature of the environment are referred to as "deep-freezing”.
  • these can be temperatures around the freezing point up to absolute zero.
  • Icing develops a number of adverse effects.
  • the risk of accidents z. B. in enter or passable cold stores significantly increased
  • icing prevent tight closing of the entrances, causing energy losses.
  • the brittleness of known sealing materials in areas of cryogenic temperatures increases and limits their applications, duration of use and sealing effect.
  • a freezer for trapped in flat bag frozen food which has a refrigerant flowing through dies in a serving as a cold chamber housing.
  • two lock chambers are present, the respective volume of closable access on the one hand with the environment and on the other hand with the volume of the cold chamber in combination.
  • the flat bag with the frozen food is introduced via the first lock chamber in the cold chamber, there pressed between the pressing tools and frozen.
  • the humidity in the first lock is reduced to a minimum value.
  • the flat bag from the cold chamber is discharged into the second lock chamber and from this into the environment.
  • Disadvantages here are volume flows which occur during insertion and removal of the flat bag in or out of the freezer.
  • the cold chamber there is a first access with a door which leads into an adjacent, likewise heat-insulated, lock chamber (henceforth lock chamber).
  • the lock chamber communicates with a closable second access to the environment.
  • a cryogenic gas volume in the cold chamber and at least one other cooled volume in the lock chamber available.
  • the temperature of the lock chamber is lowered, the effect of cooling the cold chamber nitrogen is also used for cooling the lock chamber down to -60 ° C.
  • a disadvantage of the known devices is the occurrence of volume flows in the operation of at least one of the entrances and the complex and energy-intensive measures to avoid icing.
  • the invention has for its object to show a way of energy-efficient and ice-free access to cryogenic cooling chambers through the insulated wall through, the occurrence of adverse flow rates should be avoided.
  • a device for setting cryogenic temperatures with a, a first volume enclosing cold chamber in the heat-insulated wall a closable first access is provided, via which the first volume is connected to a second volume of a heat-insulated lock chamber, also in the lock chamber there is a closable second access via which the second volume communicates with the environment of the device and the temperatures in the cold chamber and lock chamber are adjusted by the action of a cold or evaporating refrigerant, achieved by the first access having a vertical extent, which is less than the vertical extent of the lock chamber and that the second volume extends beyond the highest point of the vertical extent of the first access.
  • first and second volumes have temperature profiles over their vertical dimensions, which can be adjusted largely independently of each other. The adjustment of the temperature in the second volume is carried out so that in the region of closed second access the temperature is more than 0 ° C, whereby ice formation on the second closure is avoided.
  • the core of the invention is the creation of stable, vertical temperature stratifications in the two volumes, whereby the formation of unfavorable volume flows, especially in the supply and removal of refrigerated goods, is greatly reduced.
  • the temperature profile of the stratifications in the two volumes can be set largely independently.
  • a preferred temperature profile in the cold chamber is given by temperatures from below -100 ° C to temperatures of more than 0 ° C and up to + 25 ° C.
  • the temperatures at the upper end of the lock chamber are above 0 ° C to + 25 ° C. Areas with temperatures above 0 ° C can be referred to as hot areas, areas with 0 ° C and below as cold areas for simplicity's sake.
  • a cold or evaporating cooling gas is used.
  • This can be a gas such.
  • a cooling device In the cold chamber, a cooling device is provided which generates cryogenic temperatures in the cold chamber in a known manner.
  • systems may be used in which the withdrawal of heat energy takes place by means of appropriately sized and dimensioned heat exchangers.
  • cooling gas can also be introduced directly into the cold chamber, so that a refrigerated goods located therein is lapped by the cooling gas.
  • the cooling device is arranged on or in the vicinity of the bottom of the cold chamber. If a cooling gas is introduced directly, this advantageously takes place so that it collects at the bottom of the cold chamber and flow turbulences are avoided as far as possible.
  • Refrigerated goods are all objects or substances referred to, which are introduced for the purpose of their cooling for temporary storage in the cold chamber. Of course, substances to be cooled can also be packed.
  • the refrigerated goods can be placed, for example, in standard and laboratory standard mounts or freezer boxes.
  • buffered and unbuffered biological samples such as tissue, DNA, cell material or organelles may be stored as refrigerated goods.
  • the wall of the cold chamber is the well-known prior art, very well insulated against the environment of the device and have correspondingly low heat transfer coefficient [W / (m 2 K)] on.
  • the first access is provided with a first closure and can be locked by this, wherein the first closure does not necessarily have to close gas-tight.
  • a first closure can be actuated manually and / or by a technical device and be, for example, a stopper, a slide, a lid or a door.
  • the dimensions of the first access are selected so that the intended refrigerated goods in the opened state of the first closure can be easily moved through the first access.
  • the cold chamber may be designed one or more chambers.
  • the first access is at a vertical distance to the bottom of the cold chamber.
  • the region lying below the first access can be formed as at least one storage chamber and include devices for the systematic orderly storage of the goods to be cooled.
  • such devices include vertically movable means for Picking up the chilled goods.
  • Storage chamber and the at least one space above, hereinafter referred to as manipulation chamber may be formed so that the vertical temperature profile in the region of the transition from the storage chamber and manipulation chamber a temperature jump, preferably towards higher temperatures has. This can be achieved in that the storage chamber is spatially delimited from the manipulation chamber, as can be realized for example by a lid or a cover at the upper end of the storage chamber.
  • the manipulation chamber and the storage chamber are not thermally decoupled from each other by the spatial delimitation in the sense of two independent, heat-insulated volumes.
  • At least one engagement device that allow manipulative activities on the refrigerated goods.
  • Such engagement devices are preferably arranged so that in addition a movement of the goods to be cooled, possibly using aids and / or auxiliary devices, in and out of an optionally existing storage chamber and through the first access is possible therethrough.
  • the interventional device can be used as a manual intervention, for. B. be formed on heat-insulated gloves and / or purely mechanical devices such as gripping arms.
  • at least one viewing window is advantageously arranged in the wall of the cold chamber so that a person operating the intervention device can see into the cold chamber. It can be arranged more windows.
  • imaging systems such as cameras and / or arrangements of optical elements such as lenses and mirrors may be present.
  • An intervention device and viewing window can also be present in the lock chamber.
  • a device may be provided with which samples can be moved through the first access, which is not actuated by an intervention device, but for example by a mechanical drive and a controller.
  • the arrangement of engines, for. B. for the movement of the first closure, the engagement device and the like is preferably carried out of cold or lock chamber. If, in alternative embodiments, motors are arranged in the interior of the cold chamber or lock chamber, they can be designed to be heatable, which, however, can have a disadvantageous effect on the attainability of a stable thermal stratification and possibly means increased costs for the insulation of the motors.
  • the manipulative activities are performed in the manipulation chamber located above the storage chamber.
  • the temperature profile of the first volume is adjusted so that the manipulative activities take place at temperatures at which thawing of the chilled goods is prevented.
  • the materials making up the interventional device should remain sufficiently flexible and have a material thickness which ensures a minimum of tactile perception during the manipulative activities. It is advantageous if the manipulative activities take place at temperatures colder than -100 ° C.
  • the vertical extent of the lock chamber should not be higher than the height to which the cooling gas is lifted by the pressure existing in the cold chamber. Otherwise, there is the disadvantage that when closing the second access a residual volume of ambient air is trapped in the lock chamber and it can cause condensation and icing.
  • the gas pressure inside the device is preferably higher by 10 to 50 Pascal than the ambient pressure.
  • the insulation of the wall of the lock chamber is also designed so that their heat transfer coefficients are low and equal over the extent of the wall of the lock chamber.
  • Isolation means all measures for influencing the heat transfer coefficients.
  • An increase in the insulation can be achieved, for example, by a thicker layer of an insulating material or by the use of different insulating materials with mutually different Dämmbeat.
  • the heat transfer coefficients may increase with the vertical extent of the lock chamber. As a result, more heat is absorbed from the environment of the device in the upper regions of the lock chamber.
  • Such a structural design is a passive measure for influencing the temperature profile in the lock chamber. It can preferably be implemented by reducing the insulation and / or by using materials with a lower insulating effect.
  • Passive measures are particularly useful when the ambient temperatures of the device are largely constant and predictable. This can for example be the case in air-conditioned laboratory rooms.
  • a device for influencing the temperature preferably a heater
  • the temperature profile in the lock chamber can be actively influenced.
  • active and passive measures can also be combined.
  • All measures for adjusting the temperature gradients must be such that the dew point lies below the outer surface of the wall of the lock chamber.
  • the second access and the second closure must be arranged in the warm area of the lock chamber.
  • the second access beginning above the first access preferably closes the lock chamber upwards, but may also be arranged in a wall of the lock chamber which does not face the cold chamber.
  • the lock chamber may optionally extend below the first access.
  • the space formed thereby can be used as an intermediate storage for samples that should not be spent directly in the cold chamber.
  • the intermediate storage can be active, z. B. by a cooling device, cooled and / or passively by cold, flowing from the cold chamber and collecting in the interim storage, gas tempered.
  • sensors in particular temperature sensors, but also sensors for measuring volume flows, pressures and other physical quantities, may be present and connected to a controller in a signal-conducting manner.
  • the controller can also be connected to cooling devices in the cold and / or lock chamber, with the first and second shutters and / or with the device for influencing the temperature in the lock chamber and drive them.
  • the device uses the known fact that with increasing temperature decrease, the density of a cooling gas increases. If a cooling gas volume is not circulated or in any other way prevents the formation of a stratification, the coldest portions of cooling gas accumulate near the bottom during the The warmest portions of the cooling gas can be found in the layers that are vertically farthest from the earth's surface. It comes to the application of the device, in particular the formation of layers of different temperature, contrary, that gases have a low thermal conductivity, so that after formation of stable layers temperature profiles with steep temperature gradients, ie with high temperature differences over short distances can be generated.
  • the temperature in the cold chamber is lowered by the action of a cooling gas.
  • the first volume contained in the cold chamber cools down and becomes denser.
  • the first volume passes as a directed volume flow through the first access into the lock chamber.
  • the lowest temperature in the lock chamber is determined by the temperature of the layer which flows over the lower edge of the first access from the cold chamber into the lock chamber.
  • the temperature curves in both volumes can deviate again without influencing each other.
  • This circumstance is used to create a temperature profile in the lock chamber in which those layers which lie in the area of the second access have temperatures above 0 ° C.
  • the lying at the same horizontal height layers of the cooling gas in the cold chamber can therefore have significantly lower temperatures than in the lock chamber.
  • the second access may be located in a warm area, while the corresponding layers in the cold chamber still come to lie in a cold area.
  • the cold chamber can be cooled and a volume flow can be generated by opening the two approaches, by which the temperatures are lowered in both volumes.
  • the second access is then sealed gas-tight. It sets a pressure equilibrium between the two volumes and the volumetric flow succumbs.
  • a temperature profile is created in the lock chamber, which includes a warm area in the adjacent to the second access layers.
  • the second access is opened and the samples are placed in the lock chamber.
  • the first access is meanwhile closed, whereby the formation of a volume flow between the cold chamber and lock chamber is prevented.
  • the fact that the formation of turbulence and slightly occurring volume flows during the introduction of the samples can not be completely ruled out may even be beneficial. Thus, a leaked through the second access cooling gas can be replaced.
  • the samples are placed in the lock chamber and the second access closed. Due to the existing passive and / or active measures, the desired temperature profile is set in the lock chamber. The samples are located in the layers with the lowest temperatures of the lock chamber.
  • the first access is opened and the samples by means of z. B. an intervention device in the cold chamber.
  • the first access is closed and the samples can be manipulated in the cold chamber, stored and, if necessary, be discharged again.
  • the device according to the invention in an extremely advantageous manner to produce in the warm area of the lock chamber temperatures that are higher than the temperatures of the cold chamber and at the same time to obtain a connection between the two.
  • the heating of the cooling gas to a certain temperature allows the use of this temperature associated benefits without the adverse effects of adding other gases or mixtures.
  • a temperature around the freezing point allows the use of simple and inexpensive sealing elements on the second access and at the same time obtain the advantages of the dry cooling gas in order to obtain, for. B. to prevent icing or corrosion.
  • the device according to the invention allows access to cryogenic areas while avoiding disadvantageous icing and high cooling losses.
  • a cold chamber 1 with a first volume 2 a lock chamber 7 with a second volume 6, a first access 3 with a first closure 10 and a second access 12 with a second closure 14 to recognize as essential components.
  • a wall 4 of the cold chamber 1 and a wall 5 of the lock chamber 7 are designed to be thermally insulated.
  • a device, not shown, for low-turbulence introduction of the liquid nitrogen having a temperature of -196 ° C as the cooling gas is arranged in this embodiment at the bottom of the cold chamber 1.
  • the cooling gas can be supplied to the wall 4 of the cold chamber 1.
  • the pressure generated by the cooling gas is 30 pascals higher than the pressure Ambient pressure outside of cold chamber 1 and lock chamber 7.
  • the first shutter 10 is arranged as a manually operated slide.
  • the first closure 10 is not gas-tight and therefore allows a small gas exchange between the first volume 2 and the second volume 6 even in the closed state.
  • the vertical extent of the first access 3 begins with a small distance above the bottom of the cold chamber 1.
  • the vertical extent of the first access 3 is dimensioned smaller than the vertical extent of the lock chamber 7.
  • the bottom of the lock chamber 7 is horizontally level with the ground an insulation 11 of the walls 5 decreases in the vertical direction, whereby the heat transfer coefficient increases in the vertical direction. How out Fig. 1 can be clearly seen, the region of the decreasing insulation 11 begins above the first access 3.
  • the second access 12 At the upper end of the lock chamber 7 is the second access 12, to which a seal 13 and formed as a manually operable lid second closure 14 are present.
  • the second closure 14 is mounted inclined to the horizontal and covers the entire elevation of the lock chamber 7. In the closed state of the second closure 14 is firmly against the seal 13 and provides a gas and pressure-tight separation of the second volume 6 from the environment of the device forth ,
  • a heater 15 is arranged in the second volume 6, which is connected to a controller 16.
  • the controller 16 is also connected to a device for low-turbulence introduction liquid nitrogen and a respective temperature sensor 17 in the cold chamber 1 and the lock chamber 7. The compounds are not shown for reasons of clarity.
  • the vertical temperature profile in the cold chamber 1 ranges from -196 ° C in the cold range 18 to + 20 ° C in the hot area 19.
  • In the lock chamber 7 corresponds to the lowest temperature in the cold region 18 of the temperature of that layer extends directly over the lower edge of the first access 3, while in the hot area 19 of the second access 12 rule around + 10 ° C.
  • the first closure 10 can also be actuated hydraulically, pneumatically or electrically in further embodiments. It can also be designed hinged as a door, as a slide, cover or as a straight line in and out of the first access 3 to moving plug.
  • the actuation of the second closure 14 can also be effected electrically, pneumatically or hydraulically.
  • the second closure 14 may be realized in other embodiments as a door, slide or plug.
  • the second access 12 may be arranged horizontally and / or extend over partial areas of the tear surface of the lock chamber 7.
  • the insulation 11 of the wall 4 of the cold chamber 1 in the vertical direction decrease and thereby the formation of the hot area 19 are supported.
  • the cold chamber 1 is articulated in an upper manipulation chamber 20 and a lower storage chamber 21.
  • a cover 22 z. B. plastic which serves as a work surface for manipulative activities and at the same time the spatial separation of manipulation chamber 20 and storage chamber 21.
  • a closable with a lid opening 23 is present in the cover 22 .
  • a cylinder rotatable about its vertical axis is arranged as a storage device 24. This has vertical radiographs arranged on a radius into which shelves with standardized styrofoam freezer boxes for receiving sample containers can be lowered and removed.
  • the vertical temperature profile in the storage chamber 21 ranges from about -196 ° C to -130 ° C.
  • the temperatures of -130 ° C in the cold range 18 to + 20 ° C in the hot area 19 to.
  • the manipulation of the samples takes place in areas where temperatures are colder than -100 ° C, but can not thaw the goods to be chilled.
  • the lock chamber 7 has been increased downwards.
  • an intermediate storage 25 is created by the samples can be initially stored without the risk of thawing.
  • the intermediate storage 25 is tempered by cooling gas which flows through the first access 3 from the cold chamber 1 into the intermediate storage 25.

Claims (10)

  1. Dispositif ayant un sas d'écluse et une chambre froide pour régler des températures très basses, la chambre froide (1) renfermant un premier volume et une première entrée (3) étant présente dans la paroi isolée thermiquement de la chambre froide, ladite première entrée (3) reliant le premier volume à un deuxième volume du sas d'écluse (7) isolé thermiquement, le sas d'écluse (7) ayant une deuxième entrée (12), par laquelle le deuxième volume communique avec l'environnement externe quand la deuxième entrée est ouverte, et les températures dans la chambre froide (1) et le sas d'écluse (7) sont réglées par l'effet d'un gaz de refroidissement froid ou s'évaporant,
    - la première entrée (3) ayant une extension verticale qui est moins que l'extension verticale du sas d'écluse (7),
    - une première fermeture (10) est associée à la première entrée (3) et une deuxième fermeture (14) est associée à la deuxième entrée (12),
    caractérisé en ce que
    - la deuxième entrée (12) est disposée au-dessus de la première entrée (3) et
    - des moyens pour régler une stratification de température verticale stable sont présents dans le deuxième volume (6), par lesquels une courbe de température est réglable sur l'extension verticale du deuxième volume (6) par un apport de chaleur défini, la température étant plus haute que 0 °C dans la région de la deuxième entrée (12).
  2. Dispositif selon la revendication 1, caractérisé en ce que la deuxième fermeture (14) a un joint (13), de façon que le deuxième volume (6) peut être fermé par rapport à l'environnement d'une manière étanche au gaz et à la pression.
  3. Dispositif selon la revendication 2, caractérisé en ce que le moyen pour régler une stratification de température verticale stable est une isolation (11) décroissante de la paroi (5) du sas d'écluse (7) commençant au-dessus de la première entrée (3), de façon que la paroi (5) du sas d'écluse (7) a un coefficient de transmission thermique croissant sur son tracé vertical vers le haut.
  4. Dispositif selon la revendication 2 ou 3, caractérisé en ce que le point de rosée est au-dessous de la surface externe de la paroi (5) du sas d'écluse (7).
  5. Dispositif selon les revendications 1 à 4, caractérisé en ce qu'il y a un chauffage (15) dans le deuxième volume (6) au-dessus de la première entrée (3), ledit chauffage (15) étant lié à un contrôle (16).
  6. Dispositif selon une des revendications précédentes, caractérisé en ce qu'une stratification de température verticale stable avec des courbes de température dans la plage entre -200 °C et +25 °C est présente aussi bien dans le premier volume (2) de la chambre froide (1) que dans le deuxième volume (6) du sas d'écluse (7) pendant les périodes, pendant lesquelles la deuxième entrée (12) est fermée, les courbes de température respectives étant réglables largement indépendamment les unes des autres.
  7. Dispositif selon une des revendications précédentes, caractérisé en ce que des fenêtres d'observation (9) sont présentes dans la paroi (4) de la chambre froide (1) et/ou la paroi (5) du sas d'écluse (7).
  8. Dispositif selon une des revendications précédentes, caractérisé en ce qu'au moins un dispositif d'intervention (8) est disposé dans la paroi (4) de la chambre froide (1) et/ou la paroi (5) du sas d'écluse (7), des activités manipulatrices ciblées étant réalisables par ce dispositif d'intervention (8) dans le premier et/ou deuxième volume (2, 6).
  9. Dispositif selon une des revendications précédentes, caractérisé en ce que la chambre froide (1) consiste en au moins une chambre de manipulation (20) avec la première entrée (3) et au moins une chambre de stockage (21) localisée en direction verticale au-dessous de la chambre de manipulation (20).
  10. Dispositif selon une des revendications précédentes, caractérisé en ce que le sas d'écluse (7) a un espace formé en tant que stockage intermédiaire (25) au-dessous du bord inférieur de la première entrée (3).
EP11153066.3A 2010-02-08 2011-02-02 Dispositif de réglage de températures très basses Not-in-force EP2354729B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010007686A DE102010007686A1 (de) 2010-02-08 2010-02-08 Vorrichtung zur Einstellung tiefkalter Temperaturen

Publications (2)

Publication Number Publication Date
EP2354729A1 EP2354729A1 (fr) 2011-08-10
EP2354729B1 true EP2354729B1 (fr) 2016-12-14

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DE (1) DE102010007686A1 (fr)

Cited By (3)

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US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
USD1002868S1 (en) 2020-12-09 2023-10-24 TMRW Life Sciences, Inc. Cryogenic vial carrier
US11817187B2 (en) 2020-05-18 2023-11-14 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage

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GB2557906B (en) * 2016-11-14 2020-05-20 Ideabatic Ltd A portable temperature-stable storage device
DE102016124720B4 (de) * 2016-12-16 2019-08-14 KD Maennel GmbH Kryolagerungsvorrichtung zur Lagerung von Proben, insbesondere zur Tieftemperatur-Lagerung von biologischen Proben

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
US11817187B2 (en) 2020-05-18 2023-11-14 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage
USD1002868S1 (en) 2020-12-09 2023-10-24 TMRW Life Sciences, Inc. Cryogenic vial carrier

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DE102010007686A1 (de) 2011-08-11
EP2354729A1 (fr) 2011-08-10

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