EP2342017A1 - Réseau de réacteurs pour la fabrication et l'analyse de produits - Google Patents

Réseau de réacteurs pour la fabrication et l'analyse de produits

Info

Publication number
EP2342017A1
EP2342017A1 EP09760476A EP09760476A EP2342017A1 EP 2342017 A1 EP2342017 A1 EP 2342017A1 EP 09760476 A EP09760476 A EP 09760476A EP 09760476 A EP09760476 A EP 09760476A EP 2342017 A1 EP2342017 A1 EP 2342017A1
Authority
EP
European Patent Office
Prior art keywords
vessels
vessel
lid
array according
cover
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09760476A
Other languages
German (de)
English (en)
Inventor
Michael Gruss
Matthias Ridder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to EP09760476A priority Critical patent/EP2342017A1/fr
Publication of EP2342017A1 publication Critical patent/EP2342017A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates

Definitions

  • the present invention relates to a reactor array for the production and / or analysis of products with a plurality of vessels in which products can be prepared and / or analyzed on a preparative or analytical scale.
  • An analysis method is the X-ray powder diffractometry, which is a standard method, for example, in the determination of the polymorphism of substances.
  • an X-ray beam is successively directed to a product to be analyzed on the sample carrier and the portion of the radiation diffracted therefrom is evaluated.
  • This method can be used in transmission or reflection geometry.
  • no reactors are known in the prior art, for example EP 1972 377 A2 and US Pat. No. 6,507,636 B1, which simultaneously optimally meet the requirements of chemical synthesis and / or crystallization and those of an optimal sample carrier, for example the X-ray analysis is sufficient.
  • each vessel has at least temporarily a gas-tight lid and at least the bottom of each Vessel has a low X-ray absorption.
  • the reactor array has a multiplicity of vessels for the production and / or examination of products.
  • products are prepared on a preparative or analytical scale or the vessels are filled with products for their analysis.
  • Preparative or analytical scale in the context of the invention relates to vessels with up to 50 ml filling volume and / or 5 g filling weight, preferably up to 2 ml filling volume and / or 500 mg filling weight, particularly preferably up to 0.5 ml filling volume and / or 50 mg filling weight of the substance to be synthesized and / or to be analyzed.
  • each of these vessels now at least temporarily has a gas-tight lid, which in particular retains vapors of organic solvents at temperatures of preferably 0-120 ° C.
  • the loss of solvent or gas by leakage is at most 20% of the filling volume in 24 hours, more preferably at most 10% of the filling volume in 24 hours, most preferably at most 1% of the filling volume in 24 hours, at a temperature of 30 0 C below , preferably 15 ° C below, most preferably at the boiling point of the solvent or gas relative to the pressure surrounding the vessels.
  • the lid is located on the vessels. For analysis, the lid is preferably removed.
  • the vessel and / or its lid consists of a chemically inert material and / or is coated with a chemically inert material.
  • Chemically inert materials include glass, ceramics, stainless steels and some plastics.
  • the vessel and / or its lid is designed or dimensioned such that it is dimensionally stable both against overpressure and underpressure.
  • the vessel is made of a thermally conductive material, so that the production and / or analysis of the product can be carried out with heat and / or heat dissipation.
  • the vessel is easy to fill and easy to empty. For example, it has no undercuts and no sharp corners.
  • the vessel has means for mixing the vessel during manufacture of the product and / or during the analysis. This mixing is preferably carried out by shaking and / or stirring.
  • the lid and / or the vessel by deep drawing, casting, tips or injection molding of a plastic produced. Further preferred production methods are cutting processes or rapid prototyping (solidification of a plastic powder or granulate). In this case, a variety of lids or vessels can be produced simultaneously. Their separation, if desired, takes place before or after the joining of lid and vessel.
  • the bottom of the vessel is designed so that it has the highest possible transmission with respect to X-rays, preferably in a wavelength range of 0.45 - 2.5 A.
  • the bottom of the vessel preferably has a thickness of less than or equal to 5 mm, particularly preferably less than or equal to 100 ⁇ m, and is particularly preferably produced from a X-ray amorphous material.
  • the filling level and the filling density of the products in the vessels are each as identical as possible in order to obtain the best possible comparability of the measurements in both the X-ray reflection and the X-ray transmission analysis.
  • the lids of the individual vessels are interconnected, so that they can be applied to all vessels in one operation or removed from all vessels.
  • the vessels are stored on a plate in bearings provided therefor.
  • a plate according to the invention need not be a continuous plate, but may have recesses.
  • a plate according to the invention is also a structure in which the storage of the individual vessels are connected by webs.
  • the plate according to the invention will generally not be flat, but have elevations and / or indentations, for example for storage of the vessels or for removing the lid from the vessels.
  • the storage of the vessels in each case one or more bearings and / or a common heat exchange means, with which the respective vessel can be heated or cooled.
  • the temperature in each vessel is individually adjustable.
  • the plate in each case has a lid opener with which the lid can be removed from the vessel, preferably automatically.
  • a lid opener with which the lid can be removed from the vessel, preferably automatically.
  • This is preferred, especially immediately, prior to analysis of the products.
  • This is particularly advantageous in the case of X-ray analysis because the lid then does not impede the transmission of X-rays represents.
  • all lids are removed simultaneously from the respective vessels.
  • the removal of the lid is carried out by their particularly preferred reversible deformation. By the deformation of a positive and / or positive connection between the lid and vessel is repealed and the lid can be removed from the respective vessel.
  • the removal of the lid is carried out by a lowering movement of the vessel and the lid.
  • each lid has means for attaching, for example, process engineering apparatuses, metering devices and / or measuring devices to the lid.
  • the vessel is rotatably disposed in the storage.
  • This preferred embodiment of the present invention has the advantage that the vessel can be rotated, for example, during analysis of the product therein. As a result, measurement errors are at least reduced, for example due to different filling levels, varying filling density and a specific orientation of crystals or preferred orientation of the crystals.
  • the vessels for each have a drive means.
  • This drive means can act positively and / or non-positively, for example with a drive belt or a drive wheel together.
  • the vessels may also have non-contact drive means, for example means which are flowed by a gas or liquid flow or by electromagnetic action, the respective vessel set in rotation.
  • the drive is contactless by a temperature-controlled gas or liquid flow, which allows the setting of different temperatures. This is for example advantageous in the investigation of substances whose properties are temperature-dependent (for example, polymorphs or solvates).
  • the respective vessel is arranged in a separately provided from the plate storage, which storage is then preferably set in rotation.
  • Another object of the present invention is a lid array having a plurality of individual lids, which are arranged in a grid.
  • the cover array according to the invention is particularly suitable as a retrofit kit for existing reactor arrays.
  • the lid array is made of a flexible material.
  • Flexible in the context of the invention means that the material of the lid array is sufficiently flexible that it can be removed by bending successively from the reactor array without, for example, a peel aid is needed and without the lid is damaged and the reactor array then closed again can be.
  • each lid has a seal.
  • This seal can be made of the same or different material as the lid.
  • FIGS. 1-13 These explanations are merely exemplary and do not limit the general inventive concept.
  • FIG. 1 shows the reactor array
  • Figure 2 shows the lid in three views.
  • FIG. 3 shows a first embodiment of the vessel with lid.
  • FIG. 4 shows a second embodiment of the vessel with lid.
  • Figure 5 shows procedural and metering in the
  • Figure 6 shows an ejector
  • FIG. 7 shows a further embodiment of the ejector.
  • FIG. 8 shows interconnected vessels.
  • FIG. 9 shows a particularly flat embodiment of the vessel
  • FIG. 10 shows a first embodiment of rotatably arranged
  • FIG. 11 shows drive means for the vessel
  • FIG. 12 shows the assembly of the arrangement according to FIG. 11.
  • Figure 13 shows another example of the assembly of the device
  • FIG. 1 shows the reaction array 1 according to the invention, which has a multiplicity of vessels 3, here in an arrangement 8 ⁇ 12, which are arranged, for example, on a plate 5.
  • the arrangement of the vessels 3 is preferably equidistant from a uniform pattern.
  • FIG. 2 shows schematically the associated lid in three views.
  • Each vessel has a lid with gas-tight seals 13, which is mounted on a respective vessel.
  • the lids are arranged contiguously. However, this need not be the case and / or is only temporary.
  • the lids remain connected to each other. They remain during the production of the respective product and / or until the vessels are placed on the plate on the vessels and are then preferably removed for analysis and then optionally re-attached to the vessels.
  • the individual vessels can be held together by interconnected lids.
  • FIG. 3 shows a first embodiment of the vessel 3, which is provided with a cover 2.
  • a seal 13 between the lid and the vessel.
  • the vessel is of two made of different materials, wherein the bottom has a low absorption with respect to X-rays.
  • On the lid 2 means for the arrangement of a process engineering apparatus, such as a reflux cooling, and / or a dosing means are arranged.
  • the cover has two positive locking means 2.1, which cooperate with positive locking means 5.2 of the underlying plate and thus fix the vessel together with the holder in a very specific position, which is advantageous for the heat transfer and the mixing process.
  • the underlying plate 5 further comprises heat exchange surfaces 5.1, with which it is possible to heat or cool the vessel 3, wherein the shape of the heat exchange surface is preferably adapted to the shape of the bottom of the vessel.
  • the cover 2 are shown without connection to each other, but this need not be the case or only temporarily the case.
  • FIG. 4 essentially shows the vessel 3 together with the lid 2, wherein, in the present case, the lid has no means 9 for the arrangement of process engineering apparatuses and / or metering devices.
  • FIG. 5 shows, in addition to the example according to FIG. 3, the arrangement of a process engineering apparatus 14, in this case a reflux condenser, on the cover 2. Furthermore, it can be seen that the cover 2 has a recess through which a metering unit, here a syringe, is feasible, with which a solid, a liquid or a gas can be injected into the vessel.
  • a metering unit here a syringe
  • the plate 5 has ejectors 8, the upper end of which when lowering the vessels 3 together with the cover 2 interact with the positive locking means 2.1 of the cover and thereby spread the cover outwards.
  • a positive and / or non-positive connection 21 which secures the lid 2 to the vessel 3, dissolved and the lid 2 can be removed.
  • the plate 5 in the present case, a spring means 16, with which the downward movement of the vessel 3 can be cushioned.
  • an ejector 8 is arranged in each case between four covers 2, each cover having a plurality of, here four, clamps 2.1, with which a releasable positive and / or non-positive connection with the vessel 3 can be produced in each case.
  • FIG. 8 shows that the vessels 3 can also be connected to one another by webs 3.1.
  • all vessels 3 can be positioned simultaneously on a plate 5 and / or a heat exchange between the vessels via the webs 3.1 can take place.
  • the compound 3.1 can optionally be solved by cutting.
  • FIG. 9 shows a particularly flat embodiment of the vessel 3. This vessel is particularly suitable for X-ray powder diffractometry. Otherwise, reference is made to the execution of Figure 3.
  • FIG. 10 shows an embodiment of the present invention in which the vessel 3 and / or its lid 2 and / or its holder are provided with drive means 11.
  • the drive means 11 are blades, which are arranged at a uniform distance along the circumference of the vessel or the lid or along the holder and which, if necessary, can be flowed through by an air flow 17, the vessel 3 and / or lid 2 and / or whose holder rotates drives.
  • an air flow can also be directed laterally and / or from below against the vessel and / or its storage, for example, the frictional resistance between the vessel 3 and its holder and / or between the holder and the reduce underlying plate and / or drive the vessel.
  • FIG. 11 shows an insert 19 provided with air blades 11, which is arranged in a bearing 6 of the plate 5.
  • the vessel 3 is arranged in the insert 19. Again, the blades 11 are driven by air.
  • the drive means 11 can also be belts or toothed wheels or any other means with which a force and / or a torque for rotary drive of the vessel 3 can be impressed.
  • FIG. 12 essentially shows the illustration according to FIG. 11, it being possible to see how the bearing 6, the insert 19 and the vessel 3 interact.
  • FIG. 13 essentially shows the illustration according to FIGS. 11 and 12, wherein here the inserts 19 are arranged on a plate 20 and are lowered into the bearing 6 by means of the plate 20.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

La présente invention porte sur un réseau de réacteurs pour la fabrication et/ou l'analyse de produits avec une pluralité de cuves, dans lesquelles les produits sont aptes à être fabriqués à une échelle préparative ou analytique.
EP09760476A 2008-10-28 2009-10-26 Réseau de réacteurs pour la fabrication et l'analyse de produits Withdrawn EP2342017A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09760476A EP2342017A1 (fr) 2008-10-28 2009-10-26 Réseau de réacteurs pour la fabrication et l'analyse de produits

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08018762 2008-10-28
EP09760476A EP2342017A1 (fr) 2008-10-28 2009-10-26 Réseau de réacteurs pour la fabrication et l'analyse de produits
PCT/EP2009/007643 WO2010049108A1 (fr) 2008-10-28 2009-10-26 Réseau de réacteurs pour la fabrication et l'analyse de produits

Publications (1)

Publication Number Publication Date
EP2342017A1 true EP2342017A1 (fr) 2011-07-13

Family

ID=40445239

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09760476A Withdrawn EP2342017A1 (fr) 2008-10-28 2009-10-26 Réseau de réacteurs pour la fabrication et l'analyse de produits

Country Status (3)

Country Link
US (1) US9339816B2 (fr)
EP (1) EP2342017A1 (fr)
WO (1) WO2010049108A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2598245B1 (fr) 2010-07-27 2019-06-26 InSphero AG Boîte à culture à cavités multiples

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341587A2 (fr) * 1988-05-11 1989-11-15 Dupont Canada Inc. Appareil pour recueillir du sang

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342581A (en) * 1993-04-19 1994-08-30 Sanadi Ashok R Apparatus for preventing cross-contamination of multi-well test plates
US6106783A (en) * 1998-06-30 2000-08-22 Microliter Analytical Supplies, Inc. Microplate assembly and closure
US6507636B1 (en) 2000-02-10 2003-01-14 Studiengesellschaft Kohle Mbh Rapid X-ray diffraction screening method of polymorph libraries created in multi-well plates
JP2002010777A (ja) 2000-06-30 2002-01-15 Precision System Science Co Ltd 反応容器、反応装置および反応液の温度制御方法
US6890488B2 (en) * 2001-06-22 2005-05-10 Matrix Technologies, Inc. Apparatus for sealing test tubes and the like
EP1444041A2 (fr) * 2001-09-21 2004-08-11 Solvias AG Systeme de scellement pourvu de canaux d'ecoulement
US7230242B2 (en) * 2002-06-05 2007-06-12 Quantomix Ltd Methods for SEM inspection of fluid containing samples
US20030235519A1 (en) * 2002-06-24 2003-12-25 Corning Incorporated Protein crystallography hanging drop lid that individually covers each of the wells in a microplate
US20040258563A1 (en) * 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
FI20075192A0 (fi) * 2007-03-23 2007-03-23 Bioinnovations Oy Menetelmät analyysien valmistelemiseksi ja suorittamiseksi

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341587A2 (fr) * 1988-05-11 1989-11-15 Dupont Canada Inc. Appareil pour recueillir du sang

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010049108A1 *

Also Published As

Publication number Publication date
WO2010049108A1 (fr) 2010-05-06
US9339816B2 (en) 2016-05-17
US20110257048A1 (en) 2011-10-20

Similar Documents

Publication Publication Date Title
EP2205716B1 (fr) Microréacteur
DE60224033T2 (de) Kombinatorisches chemisches reaktionssystem
AT409422B (de) Rotationsrheometer
WO2009065662A1 (fr) Appareil de laboratoire avec un espace de travail protégé
WO1992001513A1 (fr) Plaque comportant au moins un puits destine a recevoir des substances chimiques et/ou biochimiques et/ou microbiologiques et procede de fabrication de la plaque
DE202014011349U1 (de) Anlage zur Herstellung von dreidimensionalen Siebdrucken
EP3229965A2 (fr) Corps de régulation de température pour plaque multipuits et procédé et dispositif pour congeler et/ou décongeler des échantillons biologiques
DE102013109450A1 (de) Expositionsapparat
EP2408563A1 (fr) Dispositif de positionnement de porte-échantillon
EP0267408B1 (fr) Bioréacteur pour culture de matériau biologique
DE3220444A1 (de) Pipetten-probenehmer
EP2428273A1 (fr) Dispositif de thermorégulation pour la fixation thermique de billes de matière active
EP2342017A1 (fr) Réseau de réacteurs pour la fabrication et l'analyse de produits
DE19713993A1 (de) Verfahren und Vorrichtung zum Temperieren und Schütteln von Proben in Probengefäßen
DE3008061A1 (de) Verfahren und vorrichtung zum einbringen einer sonde in ein gefaess mit einem fluid
DE102007031028A1 (de) Steckverbindungsvorrichtung mit Temperaturmesskern
EP4059592A1 (fr) Éprouvette, ainsi que dispositif et procédé de dispersion et d'homogénéisation
DE9209540U1 (de) Vorrichtung zur Kultivierung von Mikroorganismen
EP2160599B1 (fr) Procédé et dispositif de positionnement et, éventuellement, d'orientation d'un objet
EP3380600B1 (fr) Porte-sonde et procédé d'agencement d'une sonde
DE19518192C2 (de) Meßvorrichtung und Meßanordnung für medizinische Geräte
EP1528856B1 (fr) Cryoconservation avec un agent de refroidissement gazeux ou a l'etat de vapeur
EP3612296B1 (fr) Dispositif et procédé d'agitation de liquides et de produits en vrac
EP3514223A1 (fr) Multicapteur pour un bioréacteur, bioréacteur, procédé de fabrication d'un multicapteur et de mesure de paramètres
DE102013204648A1 (de) Gewebekassette mit Vorspannung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110530

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: AL BA RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GRUSS, MICHAEL

Inventor name: RIDDER, MATTHIAS, DR.

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20130326

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20180703

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20181114