EP2262560A1 - Fermeture inviolable avec une goupille de retenue - Google Patents

Fermeture inviolable avec une goupille de retenue

Info

Publication number
EP2262560A1
EP2262560A1 EP09716319A EP09716319A EP2262560A1 EP 2262560 A1 EP2262560 A1 EP 2262560A1 EP 09716319 A EP09716319 A EP 09716319A EP 09716319 A EP09716319 A EP 09716319A EP 2262560 A1 EP2262560 A1 EP 2262560A1
Authority
EP
European Patent Office
Prior art keywords
break
tamper
evident closure
closure according
cone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09716319A
Other languages
German (de)
English (en)
Inventor
Christiane Lowke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of EP2262560A1 publication Critical patent/EP2262560A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3106—Plugs for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • the invention relates to a tamper-evident closure for a container or a syringe with a lockable taper adapter, which is sterile sealed by a rubber stopper and secured by a locking sleeve, wherein on the cone adapter lock unsuspected deferred locking sleeve from a holding part, a break-off and a between see this Parts located break-off zone consists.
  • EP 1 034 810 B1 likewise discloses a tamper-evident closure with a part which can be partly removed by breaking off
  • Locking sleeve known. Again, the rubber stopper is pulled off the cone adapter when canceling the breakaway.
  • the present invention is based on the problem of developing a tamper-evident closure for a container or a syringe which ensures safe handling of the combination of container or syringe and tamper-evident closure. tet and can be removed in a simple way partially so that the container or the syringe is then still sterile closed.
  • the break-off part of the safety cap surrounds the rubber stopper without radial contact.
  • the break-off part has a holding pin whose free end-with the tamper-evident closure attached-rests axially on the rubber stopper.
  • the break-off part has at least two open breakthroughs.
  • the length of the break-off part is at least twice the length of the internal thread of the tapered adapter lock.
  • the present tamper-evident closure is used for filled containers or syringes.
  • he guarantees a secure and sterile closure of a cartridge filled with a magnetic resonance tomography diagnostic agent.
  • this cartridge including its tamper-evident closure, must be sterilized by autoclaving.
  • no residual liquid must remain in the region of the tamper-evident closure during the drying process.
  • the parts involved touch: female thread adapter, rubber stopper and safety cap, mainly via line and / or point contact.
  • the tamper-proof cap has a break-off part surrounding the rear part of the rubber stopper without contacting it in the radial direction with respect to the center line of the tamper-evident stopper. However, it presses the rubber stopper against the outer cone of the lockable cone adapter. By this design, it is possible to separate or tear the break-off part of the fuse cap of the holding part, without the rubber plug is removed from the outer cone.
  • FIG. 1 Syringe with attached female thread adapter
  • Figure 4 opened syringe, the rubber stopper is removed
  • Figure 5 longitudinal section A-A, transverse to the illustration
  • FIG. 6 longitudinal section B-B, cf. Cutting process after
  • FIG. 7 cross section through the safety cap, cf.
  • FIG. 8 cross-section through the safety cap, the lockable taper adapter and the rubber stopper, cf. Sectioning of Figure 6;
  • Figure 9 Perspective view of the fuse cap obliquely from above;
  • FIG. 10 interior view of the safety cap
  • Figure 11 as Figure 9, but pivoted by about 170 degrees.
  • the present tamper-indicating closure serves in the exemplary embodiment for the sterile closing of a syringe cylinder (10).
  • the syringe barrel (10) has a lockable conical connection in the form of an outer cone (12) with a snap-in female thread adapter (20).
  • the outer cone (12) is closed with a rubber stopper (40), cf. FIG. 1.
  • a securing cap (60) is slipped over the internal thread adapter (20) and the rubber stopper (40), cf. FIG. 2.
  • the syringe cylinder (10) has a cylinder bottom (11) which merges in a funnel shape into an outer cone (12).
  • the outflow bore (13) has a cross section of, for example, 5.6 mm 2 .
  • truncated cone section (14) which has a cone angle of approximately 14 degrees and tapers in the direction of the outer cone (12).
  • the length of the truncated cone section (14) is about 1/3 of the length of the Luer outer cone.
  • the internal thread adapter (20) is a tubular body with a central stepped bore (22).
  • the latter consists of a threaded zone (23) and a plurality of bore sections (26, 28, 29).
  • the threaded zone (23) has an internal thread (24), eg a double-threaded right-hand thread with a 5 mm pitch, cf. DIN 13090, Part 2.
  • a front bore portion (26) having a diameter which is slightly smaller than the core diameter of the internal thread (24).
  • the adapter base (27) On the bore portion (26) follows an adapter base (27) with a central bore (28).
  • the adapter base (27) ' is an inner flange which sits with play in the annular channel (17) of the syringe barrel (10).
  • the internal thread adapter (20) essentially has a cylindrical outer wall (31), at which several, e.g. 12, longitudinal webs (32) are arranged, cf. Figures 1 and 6.
  • the straight longitudinal webs (32) are distributed equidistant on the circumference of the outer wall (31). They start approx. 0.8 mm below the upper end face (21) with a 45 ° bevel and extend to the lower end face (38).
  • the upper end face (21) is at its outer edge e.g. rounded off with a 0.5 mm radius.
  • the individual longitudinal ribs (32) have a semicircular cross section, whose location on the basic cross-sectional chord ⁇ length is about half as long as the arc length of the respective gap (33) between two adjacent longitudinal webs (32).
  • an elastic rubber stopper (40) see. Figure 5, which closes the outer cone (12) tight and sterile.
  • the rubber stopper (40) which may also be made of an elastic plastic, is divided into two areas: a sealing area (41) and a grip area (51).
  • the sealing region (41) consists of a tubular section whose outer and inner walls each form at least approximately a frustoconical surface.
  • the inner wall (48) has a cone angle with a bevel winkelverj ⁇ ngung of l: 16 2/3, see FIG. Luer inner cone according to DIN
  • the outer wall (46) has a cone angle of about 3 degrees, wherein the imaginary tip of the cone, for example according to Figure 5, below the sealing area in the region of the syringe barrel (10).
  • Figure 4 has a bottom (43) which is curved spherically in the outflow bore (13). Possibly. is at the bottom (43) also an example conical Zap ⁇ fen (44) formed, which partially tightly protrudes into the outflow bore (13), see. dashed line in Figure 5.
  • the blind hole (42) protrudes into the adjacent grip area (51) with about one fifth of its length.
  • the gripping area (51) has essentially the shape of a conical bolt, on whose outer wall (55) a plurality of gripping bars (56), e.g. ten, are molded.
  • the outer wall (55) has a cone angle of about 5 degrees.
  • the handle webs (56) have over their entire length a constant cross-section. It has the shape of a circle section whose height is for example one third of the corresponding circle diameter.
  • the chord length in the cross-sectional base of the grip webs (56) is approx. three times as long as the arc length of the respective gap between two adjacent handle bars (56).
  • the grip webs (56) are spherically rounded and form an axial collar (57).
  • the outer diameter to the outer wall (46) of the sealing region (41) tapers by approximately 66% of the maximum diameter of the grip region (51).
  • the grip region (51) has an upper end surface (52), which may be, for example, u.a. according to Figure 7 is stepped.
  • a circular edge (53) adjoins the grip webs (56), which projects slightly beyond the handle web (56).
  • the rubber plug (40) projects with the sealing area (41) after placing on the outer cone (12) completely in the threaded zone (23) of the female threaded adapter (20), but without touching the bottom of the threaded zone (23).
  • the rubber stopper (40) is radially expanded so far that it partially contacts individual threads of the thread (24), cf. 8).
  • the rubber stopper (40) bears with increased clamping force, since the rubber stopper wall thickness is greater in the grip area (51) than in the sealing area (41).
  • the bottom (43) contacts the upper end surface (18) of the outer cone (12) in an e.g. flat ring surface.
  • the lower handle bar ends and possibly also the collar (57) lie on the upper end face (21) of the female thread adapter (20).
  • the safety cap (60) is slipped over the assembled combination of syringe barrel (10), female thread adapter (20) and rubber stopper (40) shown in FIG.
  • the first one-piece safety cap (60) comprises a front holding part (61) and a rear break-off part (81). Between both parts (61) and (81) is a break-off zone (97).
  • the safety cap (60), cf. 6, is a cup-shaped body with a bottom (91), in which the successive outer walls (63, 83) of the holding part (61) and the break-off part (81) have a truncated cone-shaped basic shape.
  • the cone angle of the basic shape is e.g. an angle.
  • the diameter of the outer walls (63, 83) increases with increasing distance from the bottom (91).
  • twelve distributed on the circumference retaining webs (64, 84) are arranged. All e.g. In the longitudinal direction of the safety cap (60) aligned holding webs (64, 84) have trapezoidal cross-sections. These partially different cross sections also taper towards the bottom (91).
  • the holding member (61) has a frustoconical inner wall (68) whose cone angle is e.g. 1.2 angular degrees.
  • the inner diameter of the inner wall (68) here increases toward the break-off zone (97).
  • the inner wall (68) has in the region of the lower end face (78) of the holding part (61) a partially encircling latching web (71), cf. Figures 10 and 11.
  • the radially inwardly projecting locking web (71) has a Aufschiebeflanke (72) and a retaining edge (73).
  • the slip-on flank (72) has a cone angle of 40 degrees.
  • the imaginary tip of the cone lies in the area of the break-off zone (97).
  • the holding flank (73) has a cone angle of 120 degrees.
  • the imaginary tip of this cone lies in the area of the lower end face (78).
  • the outer wall (63) of the holding part (61) has a shoulder (65) of smaller wall thickness in the lower region. In the longitudinal direction, paragraph (65) has a length which is approximately 33% of the corresponding outside diameter. This outer diameter is smaller by about 6% than the diameter of the adjacent outer wall (63). Due to the wall thickness reduction, approximately 46%, the holding part (61) has a greater elasticity in the region of the latching web (71) than in the rest of the holding part (61).
  • the step (65) tapering towards the lower end face (78) has a cone angle of two angular degrees.
  • the holding part (61) has a length which is approximately 1.13 times greater than the average diameter of the holding part (61).
  • the inner wall (68) has two inner webs (75, 86), e.g. extend over the entire length of the safety cap (60). These are interrupted in the break-off zone (97) and in the break-off part (81) by openings (85) there, cf. Figure 7.
  • the inner webs (75, 86) begin at the lower end face (78). There they are roof-shaped in the circumferential direction, cf. also FIG. 5.
  • the inner webs (75, 86) each have a trapezoidal cross-section, cf. FIGS. 7 and 8.
  • the web width is approximately half as wide as the gap (33) between the longitudinal webs (32) of the internal thread adapter (20).
  • the opposing inner webs (75) have a clearance, which is always slightly larger than the outer diameter of the outer wall (31) of the female threaded adapter (20).
  • the break-off member (81) has a frustoconical inner wall (88) having a cone angle of two angular degrees.
  • the inner diameter of this inner wall (88) tapers towards the bottom (91).
  • In the outer wall (83) are located between the retaining webs (64) four at least approximately rectangular openings (85), see. Figure 2, 9 and 11. They are in pairs next to each other, while the pairs are opposite each other.
  • the length of the openings (85) carries at least 60% of the length of the break-off part (81). According to Figure 2, the breakthroughs (85) are more than 50% in front of the rubber stopper (40). In the exemplary embodiment, the openings (85) together have an area of 52 mm 2 .
  • the bottom (91) also has two openings (92). Each has the shape of a part of a circle. They are mirror-symmetrical to a plane lying on the center line (5). Their two opening cross-sections together have an area of 4.9 mm 2 .
  • the retaining pin (93) has a length which corresponds, for example, to 64% of the mean inner diameter of the break-off part (81). Its free end face (94), with which it rests on the rubber stopper (40) when mounted, has at least an area of 3, 6 mm 2 .
  • the break-off part (81) has a length that is approximately 1.2 times larger than the average diameter of the break-off part (81).
  • This length corresponds to the average thickness of an index finger.
  • Each Abbrechsteg (98) has the shape of a crooked truncated pyramid, wherein the base of the truncated pyramid in the lower end face (96) of the Abbrechteils (81), see. FIGS. 5, 6, 2, 10 and 11. surface of the pyramid roof - ie the transition area to the holding part (61) - is about one quarter of the truncated pyramid surface area.
  • the internal thread adapter (20) is first pushed onto the outer cone (12) of the syringe barrel (10) such that its adapter base (27) engages in the annular channel (17).
  • the internal thread adapter (20) is now freely rotatable around the center line (5) on the syringe barrel (10).
  • the rubber stopper (40) is slid onto the outer cone (12) until its blind hole bottom (43) slides onto the
  • the break-off part (81) of the safety cap (60) must first be torn off in an unlocking manner.
  • the break-off part (81) between the thumb and the index finger is held like a pair of pliers and loaded to the side, see. Figure 3. If the bending moment exceeds e.g. 25 Ncm, the breaking webs (98) located in the tensile zone of the load begin to break off first. As soon as a break-off bar (98) is demolished, the rest follow.
  • the rubber stopper (40) does not abut the break-off part (81), it does not come off the outer cone (12), even if it is briefly deflected by up to 20 degrees when breaking off the break-off part (81).
  • the rubber stopper (40) is not removed until the MRI cartridge is to be used. Until then, it remains sterile closed.
  • the composite of holding part (61) and female thread adapter (20) can be freely rotated on the syringe barrel (10), which makes it possible, for example, to attach an infusion set without turning the syringe barrel (10).
  • the syringe barrel (10), the female thread adapter (20) and the safety cap (60) are made of plastic, for example.
  • each component (10, 20, 60) may be made of a special material.
  • top and bottom are used several times. They relate to the component orientation, as shown in each case in Figures 1 to 6. What's up on these drawings is also on the component above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Closures For Containers (AREA)

Abstract

L'invention concerne une fermeture inviolable pour un récipient ou une seringue avec un adaptateur conique verrouillable, qui est fermé de façon stérile au moyen d'un bouchon de caoutchouc (40) et est bloqué par l'intermédiaire d'une douille de sécurité, la douille de sécurité poussée de façon indétachable sur le dispositif de verrouillage de l'adaptateur conique se composant d'une partie de retenue, d'une partie de rupture (81) et d'une zone de rupture placée entre ces deux parties. La partie de rupture entoure le bouchon en caoutchouc sans contact radial. Elle présente une goupille de retenue (93), dont l'extrémité libre - dans le cas de la fermeture inviolable montée - porte axialement sur le bouchon en caoutchouc et elle dispose d'au moins deux percées ouvertes. La longueur de la partie de rupture correspond au moins au double de la longueur du taraudage du dispositif de verrouillage de l'adaptateur conique. Avec la présente invention, est formée une fermeture inviolable qui garantit une manipulation sûre de la combinaison d'un récipient ou d'une seringue et d'une fermeture inviolable.
EP09716319A 2008-03-07 2009-02-24 Fermeture inviolable avec une goupille de retenue Withdrawn EP2262560A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008013198A DE102008013198B4 (de) 2008-03-07 2008-03-07 Originalitätsverschluss mit Haltezapfen
PCT/EP2009/001290 WO2009109312A1 (fr) 2008-03-07 2009-02-24 Fermeture inviolable avec une goupille de retenue

Publications (1)

Publication Number Publication Date
EP2262560A1 true EP2262560A1 (fr) 2010-12-22

Family

ID=40551458

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09716319A Withdrawn EP2262560A1 (fr) 2008-03-07 2009-02-24 Fermeture inviolable avec une goupille de retenue

Country Status (9)

Country Link
US (1) US20110015578A1 (fr)
EP (1) EP2262560A1 (fr)
JP (1) JP2011513147A (fr)
KR (1) KR20100138905A (fr)
CN (1) CN101959551A (fr)
CA (1) CA2717195A1 (fr)
DE (1) DE102008013198B4 (fr)
TW (1) TW200950840A (fr)
WO (1) WO2009109312A1 (fr)

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US9717855B2 (en) 2010-12-16 2017-08-01 Becton Dickinson France Adaptor and drug delivery device
US11013865B2 (en) 2013-10-15 2021-05-25 Becton Dickinson France Tip cap assembly for closing an injection system

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EP2822621B1 (fr) 2012-03-07 2016-09-21 West Pharmaceutical Services, Inc. Dispositif de securite d'aiguille de profil radial reduit
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WO2013146296A1 (fr) 2012-03-28 2013-10-03 テルモ株式会社 Seringue
US10099012B2 (en) 2012-04-04 2018-10-16 Boehringer Ingelheim International Gmbh Closure system for an applicator attachment on a container for pharmaceutical preparations, and use, container with closure system, syringe for medical purposes, and method of assembly
EP2882478A1 (fr) 2012-08-08 2015-06-17 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament à fermeture inviolable
WO2014049097A1 (fr) * 2012-09-26 2014-04-03 Transcoject Gmbh Seringue pré-remplie
EP3030292A4 (fr) * 2013-08-07 2017-03-15 Unitract Syringe Pty Ltd Adaptateurs de raccord luer pour seringues à aiguille rétractable
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US20160220150A1 (en) * 2013-09-25 2016-08-04 Covidien Lp Surgical instrument with magnetic sensor
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WO2016181826A1 (fr) 2015-05-14 2016-11-17 ニプロ株式会社 Doseur de médicament et seringue pré-remplie
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EP3593841A4 (fr) * 2017-03-10 2020-09-02 Terumo Kabushiki Kaisha Ensemble seringue, et seringue pre-remplie
HUE047159T2 (hu) * 2017-03-31 2020-04-28 Schott Kaisha Private Ltd Fecskendõhegy-sapkás részegység, ilyen fecskendõhegy-sapkát magában foglaló fecskendõ, valamint eljárás fecskendõtest tömített zárására
KR101750352B1 (ko) * 2017-04-12 2017-06-23 조희민 재사용 방지 구조를 갖는 주사기 캡
KR101869465B1 (ko) * 2017-04-12 2018-06-20 (주)풍림파마텍 재사용 방지 구조를 갖는 주사바늘 캡
EP3646910A4 (fr) * 2017-06-26 2020-11-04 Taisei Kako Co., Ltd. Structure de confirmation d'ouverture de seringue
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KR20100138905A (ko) 2010-12-31
TW200950840A (en) 2009-12-16
DE102008013198A1 (de) 2009-09-10
WO2009109312A1 (fr) 2009-09-11
DE102008013198B4 (de) 2011-07-14
CN101959551A (zh) 2011-01-26
CA2717195A1 (fr) 2009-09-11
US20110015578A1 (en) 2011-01-20
JP2011513147A (ja) 2011-04-28

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