EP2252249A1 - Dispositif de mélange - Google Patents

Dispositif de mélange

Info

Publication number
EP2252249A1
EP2252249A1 EP09719514A EP09719514A EP2252249A1 EP 2252249 A1 EP2252249 A1 EP 2252249A1 EP 09719514 A EP09719514 A EP 09719514A EP 09719514 A EP09719514 A EP 09719514A EP 2252249 A1 EP2252249 A1 EP 2252249A1
Authority
EP
European Patent Office
Prior art keywords
adapter
adapters
mixing device
bottom wall
peripheral wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09719514A
Other languages
German (de)
English (en)
Other versions
EP2252249B1 (fr
Inventor
Reinhard Kruse
Markus Kehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sueddeutsche Feinmechanik GmbH
Sueddeutsche Feinmechanik GmbH
Original Assignee
Sueddeutsche Feinmechanik GmbH
Sueddeutsche Feinmechanik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sueddeutsche Feinmechanik GmbH, Sueddeutsche Feinmechanik GmbH filed Critical Sueddeutsche Feinmechanik GmbH
Publication of EP2252249A1 publication Critical patent/EP2252249A1/fr
Application granted granted Critical
Publication of EP2252249B1 publication Critical patent/EP2252249B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration

Definitions

  • the invention relates to a mixing device for mixing a first substance present in a first container with a second substance present in a second container
  • a first adapter with a bottom wall and preferably on a cylinder jacket suitable for receiving the first container peripheral wall
  • a cannula body surrounds at least in sections from one side of the bottom wall and from the peripheral wall and a hollow cylindrical section communicating with the cannula body extends from the opposite side of the bottom wall
  • a second adapter connectable to the first adapter has a bottom wall and preferably a cylinder shell lying for receiving the second container suitable peripheral wall, wherein at least partially surrounded by a side of the bottom wall and the peripheral wall of a cannula body from an opposite side of Bodenw tion and with the cannula body in connection standing hollow cylindrical section, wherein in composite first and second adapter, the hollow cylindrical body mesh and the first and the second adapter are releasably connected together.
  • a corresponding mixing device is known from US-B-6,558,365.
  • the adapters are connected together.
  • the hollow cylindrical axially extending portions are formed such that the adapter can be connected to each other in the manner of a screw connection.
  • the containers are introduced into the receptacles formed by the peripheral walls, which are closed with pierceable caps. Since the partially filled with powder container is under negative pressure, the present in the other container liquid is sucked, so that then the mixing of the liquid can be done with the drug.
  • the adapters are then released from each other to the container containing the drug with the adapter z. B. to connect with a syringe.
  • the corresponding hollow cylindrical section z. B. formed as a Luer connection.
  • connection between the adapters takes place directly in the region of the hollow cylindrical and interlocking sections, so that when acting on a considerably larger diameter having peripheral walls of the adapter forces can act, leading to an unwanted loosening.
  • the bottom walls are spaced from each other, so that the adapter moves against each other and thus the connection can be bent over the hollow cylindrical sections. It can also lead to tilting when screwing the adapter together.
  • DE-B-10 2006 031 712 discloses a medical transfer device which consists of a tubular part receiving a first bottle and a holding part receiving a second bottle axially displaceable therefrom.
  • a flange is arranged axially displaceable.
  • a medical transfer device according to DE-B-IO 20004 005 435 is formed in three parts, wherein also an axial displacement of the parts to each other is required to connect the bottles received by external parts together.
  • a connector for medical fluids according to DE-C-100 30 474 has a connector which consists of ultrasonically welded sections.
  • a liquid-tight closure according to US-A-3,739,933 is connected via a Renkver gleich with a bottle.
  • the present invention is based on the object, a mixing device of the type mentioned in such a way that easy assembly of the adapter can be done. Furthermore, when using an unintentional release of the adapter should be excluded from each other. Furthermore, after the connection of the adapter, there should be a unit that does not allow a relative movement between the individual adapters on the ground.
  • the object is essentially achieved in that regardless of the hollow cylindrical sections of one of the adapters emanates a first element which engages in a receiving portion of the circumferential wall of the other adapter in composite adapters, and / or the adapter materially cohesive, in particular by means Ultrasonic welding are connected.
  • the peripheral wall of at least one of the adapters to extend on both sides of its bottom wall and to have a receptacle for the first element which forms the first receiving section.
  • connection of the adapter takes place in the region of the peripheral walls thereof, so that a unit is formed, which excludes a tilting of the adapter to each other.
  • the hollow cylindrical sections only have to be dimensioned such that the fluids can flow between the containers without having to perform a holding function for the adapters.
  • each of the peripheral walls of the adapter extends to both sides of the respective bottom wall and that in the extending along the hollow cylindrical portion wall portion of the first adapter, the engaging element in the receiving element extends into the peripheral wall and / or passes over the bottom wall and is pivotable transversely to the longitudinal axis of the adapter and engages in interconnected adapters with a portion in the receptacle which extends in the extending along the hollow cylindrical portion wall portion of the other adapter.
  • the pivotable element prefferably has a section projecting on the side of the outer circumference of the circumferential wall and having a radially projecting projection on the end side, which engages in the receptacle when the adapters are connected to one another.
  • the radially projecting projection preferably extends transversely to the longitudinal axis of the adapter and has a linear or web-shaped geometry.
  • one of the adapters should have two pivotable elements diametrically opposed to its longitudinal axis and, corresponding to the other adapters, two associated receptacles such as slots.
  • the element can be referred to as a locking element and the recording as a locking receptacle.
  • the protrusion latching into the receptacle should be chamfered in its free end region or running obliquely to the longitudinal axis, so that a simple sliding of the protrusion into the upright
  • the articulation-side projecting portions of the pivotable elements should be structured.
  • axially and / or radially extending ribs can be provided.
  • a further embodiment provides that the pivotable element has a radially projecting portion with a free upper edge, which runs approximately parallel to the bottom wall of the adapter and engages behind the transverse edge of the receptacle with interconnected adapters, which is remote from the bottom wall of the receptacle having adapter lies.
  • a connection between the adapters can also be done via a Renktagen.
  • a proposal of the invention provides that from the free edge of the along the hollow cylindrical portion extending portion of the peripheral wall of one of the adapter emanates a receiving slot which merges from an edge axially extending portion in a transverse to the longitudinal axis of the adapter portion, and that from the hollow cylindrical portion facing side of the bottom wall of the other adapter, a radially outwardly projecting protruding projection, which engages in the receiving slot in composite adapters.
  • the former when the adapters are connected via a recessed joint, the former may have in cross-section a square-shaped geometry with two opposite curved outer surfaces. It can extend in corner regions, in particular in each corner region of the adapter, an outwardly angled projection for engaging in each case an associated slot of the other adapter.
  • the circumferential wall extending along the cannula body is slotted in the axial direction or has mutually spaced flexible perimeter s wall sections.
  • latching projections running transversely to the longitudinal axis of the adapter from the inner surface of the circumferential wall or peripheral walls should be provided for engaging behind a region of the container, in particular a closure cap or an edge.
  • the hollow-cylindrical portion emanating from the corresponding adapter should be designed at the end as connection connection such as Luer connection for a syringe or a syringe body.
  • the bottom wall may consist of webs or ribs, which pass into an edge portion or directly into the peripheral wall.
  • a web or rib-like design of the bottom wall has the advantage that tolerances can be better cushioned.
  • FIG. 1 shows a first embodiment of a mixing device consisting of two connectable adapters
  • FIG. 2 shows the mixing device according to FIG. 1 in a second position
  • FIGS. 1 and 2 shows the mixing device according to FIGS. 1 and 2 in perspective view
  • FIGS. 1 to 3 shows a perspective view of one of the adapters of FIGS. 1 to 3 from the connection side
  • FIG. 5 shows a perspective view of the other adapter of the mixing device according to FIGS. 1 to 3 from the connection side
  • FIGS. 6 and 7 shows the mixing device according to FIGS. 6 and 7 in perspective view
  • FIGS. 6 to 8 shows a bottom view of one of the adapters of the mixing device according to FIGS. 6 to 8,
  • FIGS. 6 to 8 are bottom views of the other adapter of the mixing device according to FIGS. 6 to 8,
  • FIG. 12 shows a fourth embodiment of a mixing device in a first side view
  • FIG. 13 shows the mixing device according to FIG. 12 in a second side view
  • FIG. 14 shows the mixing device of FIGS. 12 and 13 in a perspective view
  • FIG. 15 shows an adapter of the mixing device according to FIGS. 12 to 14 in a view from below
  • FIG. 16 is a perspective view of the other adapter of the mixing device of FIG. 12 to 14,
  • FIG. 17 shows a longitudinal section through the mixing device according to FIGS. 12 to 14,
  • FIG. 18 shows the sectional view according to FIG. 17 with filters inserted
  • FIG. 20 shows an upper adapter of the mixing device according to FIG. 19 and FIG.
  • FIG. 21 shows a lower adapter of the mixing device according to FIG. 19.
  • mixing devices for mixing fluids in particular a powdered fluid with a liquid, for the production of a medical substance are shown, without thereby the fiction, contemporary teaching should be limited.
  • the containers containing the substances or fluids are used in the mixer forming the mixing device, in order then to be able to mix the contents via a connection.
  • one of the containers is under negative pressure, so that consequently the fluid from the other container, in particular the liquid, is sucked in after production of a compound.
  • the mixing devices used for this purpose are basically intended for single use and consist of plastic and are in particular injection-molded parts.
  • FIGS. 1 to 5 there is an FIGS. 1 to 5 to be taken embodiment of a mixing device 10 of a first adapter 12 and a second adapter 14, which are shown in Figs. 1 to 3 in the assembled state and in Figs. 4 and 5 individually.
  • the upper or first adapter 12 in the drawing of FIGS. 1 to 3 is intended to receive a container in which a liquid is located.
  • a container which is under negative pressure, is used, in which a powdered medicinal substance can be located. If the containers are connected to one another via the mixing device 10, the liquid is sucked into the lower container from the upper container.
  • the upper container 12 has a bottom wall 16, on both sides of which a circumferential wall 18 lying on a cylinder jacket extends with the inner side 20 extending on the connection side and the free outer section 22.
  • the outer portion 22 has longitudinal slots 24, 26 in order to achieve a desired flexibility, which is in particular intended to insert and fix a container in the space bounded by the outer portion 22 of the peripheral wall 18 space 38 and thus formed receptacle.
  • a desired flexibility which is in particular intended to insert and fix a container in the space bounded by the outer portion 22 of the peripheral wall 18 space 38 and thus formed receptacle.
  • latching projections 32, 34 which are designed geometrically such that when properly inserting a container, a rearward engagement of an edge thereof, in particular a lid or a cap takes place. This ensures a clear positioning.
  • a corresponding inner projection 32, 34 protrudes from each wall section.
  • a cannula 36 extends from the bottom wall 16 and extending along the outer peripheral wall section 22, by means of which the closure of the container which can be introduced into the space 38 enclosed by the upper peripheral wall 22 is pierced.
  • the cannula body 36 merges on the opposite side of the bottom wall 16 into a hollow cylindrical projection 40 extending in extension of the cannula body 36 from the bottom wall 16 in the axial direction of the adapter 12 and thus of the mixing device 10 and from the inner portion 20 of the peripheral wall 18th is surrounded.
  • the second adapter 14 likewise has a bottom wall 42 which is surrounded on the circumference by a peripheral wall 44 located essentially on a hollow cylinder shell, which divides into an inner section 46 and an outer section 48 which merge into one another in the region of the bottom wall 42.
  • the outer portion 48 is considerably longer than the inner portion 46 and has a geometry and function as the outer portion 22 of the adapter 12; because the outer portion 48 is also to receive a container fixing. Accordingly, the outer portion 48 of the peripheral wall 44 is slotted.
  • a cannula body 53 extends from the bottom wall 42 and is coaxially surrounded by the outer portion 48 of the circumferential wall 44.
  • the cannula body 53 merges on the opposite side of the bottom wall 42 into a hollow cylindrical section 54 which, in the case of composite adapters 12, 14, receives the hollow-cylindrical section 40 of the first adapter 12 and is sealed off from it.
  • the adapters 12, 14 are locked.
  • the following construction is selected according to the embodiment of FIGS. 1 to 5. From the lower slots not having portion 20 of the peripheral wall 18 of the first adapter 12 go out actuating portions 56, 58, which are laterally cut off and each pass with an edge in the peripheral wall 18 and the bottom wall 16, so that a radial adjustability or Pivoting results.
  • the projection 56, 58 is biased or shaped such that a spring action takes place to the outside.
  • the free outer edge is formed as a latching projection 60, 62 which protrudes laterally beyond the peripheral edge 66 of the inner portion 20 of the peripheral wall 18.
  • the peripheral wall 44 In order to lock the first adapter 12 with the second adapter 14, the peripheral wall 44 in its inner, axially a small extent as the outer portion 48 having portion 46 corresponding geometrically adapted recordings such as passage slots 68, 70 which in composite adapters 12th , 14 receive the latching projections 60, 62.
  • an axial displacement of the adapter 12,14 mutually inhibiting positioning characterized in that in composite adapters 12, 14, the end face 72 of the edge portion 66 of the inner portion 20 of the peripheral wall 18 on the bottom wall 72 and a circumferential inner edge 74th the second adapter 14 stands up. Furthermore, there is a
  • the hollow-cylindrical section 40 of the adapter 12 sealingly engages the hollow-cylindrical section 54, so that, as a result, containers are received by the adapters 12, 14 and their closure pierced by the cannula bodies 36, 54 , Fluid from one container in the other can flow.
  • the hollow cylindrical portion 40 can receive the other hollow cylindrical portion 54 sealing.
  • the projections 56, 58 is pressed from the outside, so that the latching projections 60, 62 reach into engagement with the latching receivers 68, 70. Then, the adapter 12 withdrawn and the hollow cylindrical portion 54 of the adapter 14 z. B. connected to a syringe.
  • the hollow cylindrical portion 54 is preferably formed as a Luer connection, as indicated by the radially projecting projections 80, 82.
  • FIGS. 6 to 10 show a second embodiment of a mixing device 100 whose function corresponds to that of the mixing device 10, so that reference is made to the relevant explanations. Also, like reference numerals are used for like elements, even though geometrical deviations exist in particular in the design of the peripheral walls 118, 144 of the adapters 112 and 114.
  • each perimeter 118, 144 has an inner and an outer portion 120, 122 and 146, 148, respectively, that extend on either side of the bottom wall 116, 142.
  • FIGS. 1 to 5 is basically the formation of the locking of the adapter 112, 114 in use, which also from the top or first adapter 112 a circumferentially projecting and trained as a cutout in the peripheral wall 120 projection 156, 158, which is structured by transverse to the longitudinal direction of the mixing device 100 extending ribs.
  • the projection 156, 158 which can also be referred to as a latching element, is articulated on the bottom wall 116 so as to be radially displaceable or pivotable, or extends at a distance into the circumferential wall 118 of the adapter 112, ie is cut free.
  • the free edge of the latching element 156, 158 lying opposite the articulation region has a latching projection 160, 162 which engages in a recess 170 present in the edge region of the inner circumferential wall section 146 of the second adapter 114, which is not formed as an opening in the exemplary embodiment.
  • the latching receptacles 170 to the latching projections 160, 162 and the height of the peripheral wall section 146 to the height of a distance from the end face 166 of the section 120 extending step 176 are designed such that after assembly of
  • cannula bodies 136 likewise extend from the bottom walls 116, 142, which are likewise coaxially surrounded by the outer circumferential wall sections 122, 148 and merge into hollow cylindrical sections 140, 154 projecting from opposite sides of the bottom walls 115, 142.
  • a wing-like portion 180 projects radially outward to facilitate handleability.
  • the composite adapter 112, 114 form a closed unit on the outside, so that a problem-free use, without the risk that when inserting the containers in the adapter 112, 114 an uncontrolled Tilting or loosening occurs.
  • FIG. 11 shows a third embodiment of a mixing device 300, which likewise consists of a first adapter 312 and a second adapter 314 with circumferential walls 318 and 344, respectively, which extend into outer sections 322, 348 and inner sections 320, 346 a bottom wall 316 and 342 are separated.
  • a mixing device 300 which likewise consists of a first adapter 312 and a second adapter 314 with circumferential walls 318 and 344, respectively, which extend into outer sections 322, 348 and inner sections 320, 346 a bottom wall 316 and 342 are separated.
  • From the bottom wall 316, 342 protrude cannula or cannula body 336, 353, which are surrounded by the respective outer portion 318, 348 of the peripheral walls 318, 344 concentric.
  • the cannula bodies 336, 353 merge into cylindrical sections 340, 354, wherein - in deviation from the embodiment of FIGS. 1 to 10 - the hollow cylindrical section 340 emanating from the adapt
  • filters 380, 382 can be used in the hollow-cylindrical sections 340, 354. The same applies to the embodiments of the mixing devices 10 and 100.
  • a further embodiment of a mixing device 400 can be taken from FIGS. 12 to 18, whereby the same reference numerals are used likewise for the same elements in accordance with the embodiments of FIGS. 1 to 11.
  • the mixing device 400 differs from those discussed above essentially in that a first or upper adapter 412 is detachably connected to a second or lower adapter 414 via a rank or bayonet connection. Furthermore, the outer portions 422, 448 of the peripheral walls 418, 444 of the adapters 412, 414 are not slotted.
  • protrusions 432, 434 projecting inwardly from the inner walls of the outer sections 422, 448 engage in a latching manner in the container received in the space 430 surrounded by the respective outer section 422, 448 and thus to be positioned unambiguously.
  • a cannula body 436 which merges into a hollow cylindrical portion 440 in the lower portion 420 of the peripheral wall 418.
  • the lower circumferential wall 420 which is shorter than the outer circumferential wall 422, has slots 480 starting from its front side or end edge 472 and composed of an axial section 482 extending from the front edge 472 and a section 484 extending transversely thereto.
  • the slot 480 has approximately the course of an L.
  • the mixing device 400 and thus the adapters 412, 414 differs from the previously described embodiments in that the circumferential walls 418, 444 are circumferentially closed and do not have the profile of a hollow cylinder jacket, but in cross section a rectangular geometry with preferably curved side surfaces exhibit.
  • the circumferential walls 418, 444 are circumferentially closed and do not have the profile of a hollow cylinder jacket, but in cross section a rectangular geometry with preferably curved side surfaces exhibit.
  • two opposite side surfaces 490, 492 bent convexly outwardly, whereas the extending between these side surfaces 494, 496 are rectilinear or slightly concave.
  • the lower or second adapter 414 has the same surfaces 491, 493 and 495 and 497, respectively.
  • FIG. 17 From Fig. 17 it can be seen again how the first or upper adapter 412 is connected to the lower or second 414. Also, the inner inwardly projecting from the outer circumferentially closed wall sections 422, 448 protrusions for fixing the containers can be seen, which are designated in Fig. 17 by the reference numerals 431 and 433 purely by way of example. Furthermore, one recognizes the cannula body
  • the filter 455 present in the hollow-cylindrical section 454 may have a longitudinal extent such that the end edge of the hollow-cylindrical section 440 is seated thereon when the adapters 412 are connected to one another via the bayonet connection.
  • peripheral wall 444 of the adapter 114 only extends along the side of the bottom wall 442, on which a container is placed on the cannula body 454, so that in comparison to the exemplary embodiments of FIGS. 1 to 12 an inner portion at least partially surrounding the hollow cylindrical portion 454 is missing.
  • a fifth embodiment of a mixing device 500 results purely in principle from FIGS. 19 to 21, which corresponds to the structure and the function with the mixing device 400, so that full content is referred to the corresponding explanations.
  • the upper or first adapter 512 is connected to the second or lower adapter 514 not via a recessed connection, but by means of ultrasonic welding.
  • small spherical or cylindrical projections 521, 523 525, 527 project from the end edge region 572 of the lower portion 520 of the peripheral wall 518 of the upper or first adapter 512, which are then selectively welded to the associated end edge region 573 of the bottom wall 542 of the adapter 514.
  • To release the adapters 512, 514 it is only necessary that the adapters 420 are rotated relative to each other. This is facilitated by the wing-like projections 570, 572, 573, 574, 575.
  • Renkharm it is also possible to additionally provide a Renktagen to provide additional security.
  • the ultrasonic welding connection between the first and second adapters 512, 514 is provided in the outer edge region of the circumferential wall 520 and thus in the peripheral region of the bottom wall 542, it is of course also possible to weld other regions to one another by means of ultrasound, provided that easy accessibility is provided.
  • the punctiform connection can be made instead of by means of ultrasound also by other suitable methods for material coherent bonding.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Dispositif de mélange (10) destiné à mélanger une première substance contenue dans un premier récipient et une seconde substance contenue dans un second récipient. Les récipients sont introduits dans des adaptateurs (12, 14) pouvant être accouplés entre eux de manière libérable, et sont reliés entre eux par l'intermédiaire de canules (36) qui percent lesdits récipients. Selon l'invention, pour exclure tout mouvement relatif entre les adaptateurs lorsque ces derniers sont accouplés, lesdits adaptateurs sont reliés entre eux par l'intermédiaire d'évidements d'emboîtement qui s'étendent dans la zone des parois périphériques (22) des adaptateurs et de saillies d'emboîtement associées.
EP20090719514 2008-03-10 2009-03-10 Dispositif de mélange Not-in-force EP2252249B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200810002800 DE102008002800A1 (de) 2008-03-10 2008-03-10 Mischvorrichtung
PCT/EP2009/052788 WO2009112489A1 (fr) 2008-03-10 2009-03-10 Dispositif de mélange

Publications (2)

Publication Number Publication Date
EP2252249A1 true EP2252249A1 (fr) 2010-11-24
EP2252249B1 EP2252249B1 (fr) 2013-10-09

Family

ID=40790730

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20090719514 Not-in-force EP2252249B1 (fr) 2008-03-10 2009-03-10 Dispositif de mélange

Country Status (3)

Country Link
EP (1) EP2252249B1 (fr)
DE (2) DE102008002800A1 (fr)
WO (1) WO2009112489A1 (fr)

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DE102008002800A1 (de) 2009-09-24
EP2252249B1 (fr) 2013-10-09
DE202009018556U1 (de) 2012-03-08
WO2009112489A1 (fr) 2009-09-17

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