EP2237744B1 - Lentille intraoculaire, d'accommodation. - Google Patents

Lentille intraoculaire, d'accommodation. Download PDF

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Publication number
EP2237744B1
EP2237744B1 EP08869938.4A EP08869938A EP2237744B1 EP 2237744 B1 EP2237744 B1 EP 2237744B1 EP 08869938 A EP08869938 A EP 08869938A EP 2237744 B1 EP2237744 B1 EP 2237744B1
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EP
European Patent Office
Prior art keywords
iol
lens
chambers
shape
capsular bag
Prior art date
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Not-in-force
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EP08869938.4A
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German (de)
English (en)
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EP2237744A2 (fr
Inventor
Stephen Boyd
Cary Reich
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ForSight Labs LLC
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ForSight Labs LLC
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Priority to EP18162915.5A priority Critical patent/EP3381407A1/fr
Publication of EP2237744A2 publication Critical patent/EP2237744A2/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/02—Artificial eyes from organic plastic material
    • B29D11/023—Implants for natural eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
    • B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
    • B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
    • B23K26/062—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam
    • B23K26/0622—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
    • B23K26/0624—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses using ultrashort pulses, i.e. pulses of 1ns or less
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/00432—Auxiliary operations, e.g. machines for filling the moulds
    • B29D11/00461—Adjusting the refractive index, e.g. after implanting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K2103/00—Materials to be soldered, welded or cut
    • B23K2103/30—Organic material
    • B23K2103/42—Plastics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K2103/00—Materials to be soldered, welded or cut
    • B23K2103/50—Inorganic material, e.g. metals, not provided for in B23K2103/02 – B23K2103/26

Definitions

  • the present disclosure relates generally to the field of ophthalmics, more particularly to ophthalmic devices, including intraocular lenses (IOLs) such as accommodating intraocular lenses.
  • IOLs intraocular lenses
  • an accommodating intraocular lens is disclosed in WO-A-2004/054471 .
  • This document discloses an accommodating IOL having optical parameters that are altered in-situ using forces applied by the ciliary muscles, in which a lens body carries an actuator separating two fluid-filled chambers having either the same index of diffraction or different indices of refraction, actuation of the actuator changing the relative volumes of fluid within an optic element of the lens and altering the optical power of the lens.
  • a healthy young human eye can focus an object in far or near distance, as required.
  • Accommodation occurs when the ciliary muscle contracts to thereby release the resting zonular tension on the equatorial region of the capsular bag of the eye.
  • the release of zonular tension allows the inherent elasticity of the lens capsule to alter to a more globular or spherical shape, with increased surface curvatures of both the anterior and posterior lenticular surfaces.
  • the ciliary muscle When the ciliary muscle is relaxed, the ciliary muscle moves into the disaccommodated configuration, which is posterior and radially outward from the accommodated configuration.
  • the radial outward movement of the ciliary muscles creates zonular tension on the lens capsule to stretch the equatorial region of lens toward the sclera.
  • the disaccommodation mechanism flattens the lens and reduces the lens curvature (both anterior and posterior).
  • Such natural accommodative capability thus involves altering the shape of the lens to the appropriate refractive parameters for focusing the light rays entering the eye on the retina to provide both near vision and distant vision.
  • Intraocular lens implantation for cataracts is the most commonly performed surgical procedure in elderly patients in the U.S. Nearly three million cataract surgeries are performed each year in the U.S., with an additional 2.5 million surgeries in Europe and Asia.
  • conventional extracapsular cataract surgery the crystalline lens matrix is removed leaving intact the thin walls of the anterior and posterior capsules-together with zonular ligament connections to the ciliary body and ciliary muscles.
  • the crystalline lens core is removed by phacoemulsification through a curvilinear capsularhexis and replaced with an intraocular lens.
  • conventional IOL's even those that profess to be accommodative, may be unable to provide sufficient axial lens spatial displacement along the optical axis or lens shape change to provide an adequate amount of accommodation for near vision.
  • IOLs adapted for accommodating movement which can achieve an acceptable amount of accommodation.
  • an intraocular lens as claimed in claim 1.
  • the intraocular lens comprises an optical element adapted to be implanted in contact with the capsular bag of a human eye.
  • the optical element includes one or more chambers that are filled with a material that changes shape in response to forces acting upon the material.
  • zonular region or zonular contact region refer to the portion of the capsular bag that is typically contacted by or attached to the zonules.
  • One way to describe the zonular contact region is as the portion of the capsular bag which is contacted by the zonules and which corresponds to that defined by the equatorial apices of the capsular bag and an orthogonal projection upon the capsular bag radius from the portion of the capsular bag contacted by the zonules.
  • the determination of a capsular bag radius dimension in its accommodative or unaccommodative states can be made in various manners.
  • the determination of capsular bag radius dimension in its accommodative or unaccommodative states can be made using the Scheimpflug slit image technique ( Dubbelman, Vision Research, 2001; 41:1867-1877 ), and IR video photography ( Wilson, Trans. Am. Ophth. Soc. 1997; 95:261-266 ).
  • the aforementioned references are incorporated herein by reference.
  • the zonular contact region is about 1.5-2.0 mm radially inward from the equatorial apices along the capsular bag radius.
  • percentage (X%) of zonular contact refers to the contact or attachment area along the capsular bag defined by the equatorial apices of the capsular bag and an orthogonal from a given percentage (%) of the capsular bag radius defining the zonular contact region.
  • contacting 50% of the zonular contact region refers to contacting that portion of the capsular bag that corresponds to the portion defined by the equatorial apices and a radii of 50% of the zonular contact region radii.
  • the respective 50% would be that region defined by the equatorial apices and a contact region defined in part by the orthogonal at 0.75 mm or an orthogonal projection from 0.75 mm radially inward from the equatorial apices.
  • anterior portion of the zonular region refers to the most anterior portion of capsular bag contacted by the zonular region.
  • posterior portion of the zonular region refers to the most posterior portion of the capsular bag contacted by the zonular region.
  • shape changing optical element refers to an optical element that is made of material that enables the optical element to alter its shape, e.g. become one of more spherical in shape, thicker or focus on a closer object; or become more ovoid in shape, thinner or focus on a more distant object and thus alter the optical element's respective optics (alter the diopters of the resulting optical element).
  • accommodating shape refers to the shape of the optical element when at least one of the tensioning of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and a change in the vitreous pressure in the eye effect equatorial or polar distention of the capsular bag to effect a focusing upon a closer object.
  • An accommodating shape is generally more spherical than the disaccommodating shape.
  • disaccommodating shape refers to the shape of the optical element when at least one of the relaxation of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and a change in the vitreous pressure in the eye and a comcomittant change to a more ovoid shaping of the capsular bag to effect a focusing upon a more distant object.
  • a disaccommodating shape is generally more ovoid than the accommodating shape.
  • Capsulorhexis is the opening surgically made by puncturing, then grasping and tearing a hole in the anterior capsule.
  • ECCE extracapsular cataract extraction
  • a capsulorhexis is made in the anterior capsule and the cloudy cataract lens is extracted by phacoemulsification.
  • the accommodative IOL described herein can be used for patients after cataract surgery. It can also be used for patients with only presbyopia, but without cataract.
  • diopter refers to the reciprocal of the focal length of a lens in meters.
  • a 10 D lens brings parallel rays of light to a focus at (1/10) meter.
  • surgeons usually follow a formula, based on their own personal preference, to calculate a desirable diopter power (D) for the selection of an IOL for the patient to correct the patient's preoperational refractive error.
  • D diopter power
  • a myopia patient with -10 D undergoes cataract surgery and IOL implantation; the patient can see at a distance well enough even without glasses. This is because the surgeon has taken the patient's -10 D near-sightedness into account when choosing an IOL for the patient.
  • medially disposed within the capsular sac refers to being disposed within the generally equatorial region of the capsular bag, e.g., between the anterior and posterior portions of the capsular bag.
  • FIG. 1 shows cross- sectional view of the human eye 100 prior to implantation of an IOL.
  • the eye 100 includes an anterior portion 105 and a posterior portion 110.
  • a cornea 115 is located on the anterior portion 105.
  • the cornea 115 encloses and forms an anterior chamber 120, which contains aqueous fluid and is anteriorly bounded by an iris 125.
  • a capsular bag 130 contains the natural crystalline lens 135.
  • the capsular bag 130 includes an anterior wall 140a and a posterior wall 140b.
  • the eye 10 further includes a ciliary muscle 145 attached to the capsular bag 130 via zonules 150.
  • the vitreous humor is located posterior to the capsular bag 130 and anterior to the retina (not shown).
  • the vitreous humor contains vitreous fluid.
  • the ciliary body 145 accomplishes ocular adjustments for focusing of objects viewed at different distances.
  • the ciliary body 145 acts on the capsular bag 130 and the natural crystalline lens 135 through the zonules 150.
  • the ciliary body 145 contracts to allow the capsular bag 130 to return to a more spherical shape for viewing objects near to the viewer.
  • the ciliary body 145 retracts, the ciliary body 145 pulls on the zonules 150 to "flatten" the capsular bag 130 to permit objects at a distance to be viewed in proper focus.
  • the capsular bag 140 changes shape to appropriately distribute the light admitted through the cornea 115 and the iris 125.
  • FIG. 2 shows an IOL 205 formed of an optical body that is adapted to be implanted within the capsular bag 130 of a human eye 10.
  • the IOL 205 changes shape in response to movement of the ciliary body 145 for focusing of objects viewed at different distances.
  • the IOL 205 includes one or more layers that are formed by internal surfaces or planes 210 (represented by a dashed line in Figure 2 ) that are moveable relative to one another in order to affect the power of the IOL.
  • the planes move relative to one another, the focusing characteristics of the IOL 205 are changed to permit the lens to focus on objects at different distances.
  • the IOL 205 in Figure 2 has only a single internal plane 210 (or a pair of internal surfaces that are juxtaposed). However, it should be appreciated that the IOL 205 can include various quantities of internal planes of various shapes, sizes, and positions, as described in more detail below.
  • Each of the layers formed by the internal planes 210 comprises at least one surface formed internally within the IOL.
  • the surfaces are juxtaposed with one another such that the surfaces can slide relative to one another.
  • the presence of the layers formed by the internal planes makes the IOL 205 more susceptible to changes in shape than if the internal layers were not present.
  • at least some of the surfaces are in direct contact with one another and slidable relative to one another.
  • at least some of the surfaces are separated by a solid or liquid medium, such as hydrogel or silicone oil.
  • Each of the surfaces can act as an individual lens body that refracts light.
  • the lens material and the intervening medium each can have a refractive index that can be identical or generally identical such that reflection of light at the interface of the materials is minimized or eliminated.
  • an IOL can have lens material of silicone rubber having surfaces separated by a liquid medium of silicone oil. Silicone rubber and silicone oil have essentially the same refractive index thereby resulting in minimal light reflective effects of the juxtaposed surfaces. Similarly, any light reflective effects due to aberrations in the lens material and the creation of edges due to laser cuts within the lens would be minimized.
  • the materials and methods used in the manufacture of the disclosed IOLs are discussed in more detail below.
  • the internal layers formed by the planes can have a property such that the IOL is inclined to change shape such as in a predetermined manner.
  • the property that enables the shape change can vary and can include, for example, the structure, position, shape, size, pattern, Young's modulus, thickness, etc.
  • the property can be relative to another layer or it can be absolute property.
  • the internal layers can be positioned, shaped, sized and/or patterned to maximize the amount of shape change in one or more locations of the 1OL such as within the center of the 1OL.
  • at least one internal layer is positioned within a volume defined by 3mm radius from the geometric center of the IOL
  • Figure 3 shows a lateral, cross-sectional view of an IOL 205 having internal layers formed by planes 210 that are arranged as a series of concentric, circular-shaped surfaces.
  • the internal planes 210 are arranged in a side-by-side pattern with the planes 210 having a gradually reduced dimension D moving outwardly from the center of the IOL.
  • the internal planes 210 define surfaces internal to the IOL wherein the surface on either side of each plane 210 can move relative to one another, as represented by the arrows X1 and X2 for plane 210a.
  • the internal planes 210 can have any of a variety of contours including flat or curviplanar contours or combinations thereof.
  • Figure 4 shows a posterior, cross-sectional view of the IOL of Figure 3 .
  • the internal planes 210 when viewed from the posterior viewpoint are concentrically-arranged circles.
  • each layer formed by a plane 210 can be entirely contained within the internal volume of the IOL such that the outer surface of the IOL is uninterrupted by the presence of the internal plane.
  • at least a portion of the outer edge of an internal plane can extend to the outer surface of the IOL such that the plane forms a cleavage on the outer surface of the IOL.
  • internal planes 210 are shown as being generally parallel to one another. However, it should be appreciated that the internal planes 210 can be arranged in non-parallel relationships.
  • Figure 5 shows a lateral, cross-sectional view of an IOL 205 having layers formed by internal planes 210 that are arranged as a series of concentric spherical or partial spherical surfaces within the internal volume of the IOL.
  • the internal planes 210 are arranged in an "onion skin" fashion of gradually reducing spheres.
  • the internal planes in the arrangement of Figure 5 are not necessarily spherical but can be any type of concentrically-arranged three-dimensional shapes.
  • the planes 210 form juxtaposed surfaces that are adapted to move relative to one another as exhibited by the arrows X1 and X2 in Figure 5 .
  • the movement can be three- dimensional in that the surfaces can slide relative to one another along a plane defined by the planes themselves. In an arrangement, the surfaces can also move toward and away from one another.
  • Figure 6 shows a posterior, cross-sectional view of the IOL of Figure 5 .
  • Figure 7 shows a lateral, cross-sectional view of another arrangement of an IOL 205 wherein a layer formed by an internal plane 210 forms at least one internal core member 605 within the IOL.
  • the core member 605 can be defined by the internal plane 210 such that the surface of core member 605 can be movable relative to the remainder of the IOL 205.
  • the core member 605 can be circular in cross-section from a posterior viewpoint, although the shape of the core member can vary.
  • Figures 9 and 10 show lateral and posterior cross-sectional views, respectively, of an IOL having internal planes that form multiple core members 605.
  • the internal planes 210 can be used to form any number of core members 605 of various shapes within the IOL 205.
  • the layers formed by internal plane(s) 210 can be formed within the interior of the IOL 205 in various manners.
  • lenses such as those manufactured by Biovision (WIOLTM C/CF; WIOLTM USI; Biovision s.r.o.; Prague, Czech Republic) can be modified using any number or orientation of cuts in the lens to form internal planes that achieve movement during accommodation ( Pasta et al., "Pseudoaccommodation of WIOL CF Hydrogel lenses" ASCRS 2006 San Francisco, CA PowerPoint presentati on; http://www.biovision.cz/wiol-cf.pdf; Biovision Web Presentation).
  • an energy source can be used to form the interior planes.
  • An applicator can be coupled to the energy source and energy focused within an interior region of the IOL 205.
  • a level of energy released at a desired location or series of locations within the IOL can be sufficient to cleave a plane interior to the IOL and thereby form the internal planes 210.
  • the release of energy can be guided along a contour or pathway such that energy is released to cleave a plane of a desired shape within the IOL.
  • FIG. 11 This process is represented schematically in Figure 11 , wherein an applicator 1105 releases a stream of energy 1110 into the IOL.
  • the stream of energy can be focused at an internal location 1115 such that a sufficient level of energy is released at the location 1115.
  • the IOL can be thereby cleaved at the location 1115 to form at least a portion of the internal plane.
  • the energy source can be a laser used to form the internal plane 210 that forms the layer. Any type of laser that can be focused very precisely to achieve cleavage over a small volume of the IOL can be used.
  • the laser can be configured to form an internal cleavage in the IOL without affecting the outer surface of the IOL.
  • a femtosecond laser having a wavelength in the range of about 1100 nm to about 1200 nm is used to form the internal plane.
  • the lens can undergo a power change of approximately 0.5 diopters to approximately 5 diopters.
  • the lens is adapted to change from a first shape to a second shape during implantation into the lens capsule or after the lens has been implanted in the lens capsule.
  • the shape change can occur automatically, such as in response to a change in temperature, or it can occur upon manual activation by a clinician.
  • the lens may be manufactured of a material that is adapted to undergo a shape change in response to a predetermined stimulus.
  • the lens can be manufactured in the accommodated state and implanted into the lens capsule. During or after implantation into the lens capsule, the lens undergoes a shape change to conform to the shape of the capsule.
  • Some exemplary materials are hydrogel, acrylic and silicone.
  • the lens can be hydrated after implantation into the lens capsule to cause the lens to change shape, such as to conform to the shape of the capsule.
  • the lens may be bonded to the capsule so that the lens moves with the capsule during ciliary muscle contraction and relaxation.
  • Figure 12 shows a perspective view of an IOL 2605 in an accommodated state.
  • Figure 13 shows a cross-sectional view of the IOL 2605.
  • the IOL 2605 has an internal chamber that provides the IOL 2605 with a flexible nature that permits or encourages a shape change.
  • the chamber can be filled with a material that changes shape in response to forces acting upon the material.
  • the material can be a liquid, a gas, or a solid, including a gel. Possible materials include, but are not limited to, air, silicone, oil, and hydrogel.
  • the calculation of the lens power takes into account the type of material that is used to fill the chamber, to account for the optical interaction between the material and the inner surface of the chamber as well as the outer surface of the lens.
  • the refractive indices of the material in the chamber and the material of the lens can be selected to achieve a desired lens power.
  • the lens material and the material in the chamber can be selected to have refractive indices that are identical or generally identical such that reflection of light at the interface of the materials is minimized or eliminated.
  • Figure 14 shows a lateral view of the IOL 2605 in the accommodated state such that the zonules Z are relaxed.
  • the zonules Z are tensioned so that the IOL 2605 is in the unaccomodated state. Note that the IOL 2605 has taken on a flattened shape with respect to the accommodated state.
  • Figure 15B shows a representative displacement of the IOL 2605 as the zonules tense.
  • the IOL flattens as the zonules tense.
  • the IOL can be adapted to undergo different displacement or shape changes in different regions of the lens. For example, in the embodiment of Figure 15B , the IOL undergoes a relatively large displacement D in the central anterior region.
  • the IOL includes one or more chambers that are filled with a flowable material, such as hydrogel or silicone oil.
  • a flowable material such as hydrogel or silicone oil.
  • the material can flow from one chamber to one or more other chambers in response to stimuli.
  • the flow of material between the chambers causes the IOL to undergo a shape change.
  • Figure 16 shows a cross-sectional view of an IOL having a central chamber 3005 and one or more lateral chambers 3010 that are fluidly connected to the central chamber 3005.
  • a flowable material resides in one or more of the chambers.
  • the IOL is in an accommodated state such that all or a majority of the flowable material resides in the central chamber 3005. This causes the central chamber to have an expanded state relative to the lateral chambers 3010.
  • the flowable material flows out of the central chamber 3005 as represented by arrows F in Figure 17 .
  • the material flows into the lateral chambers 3010 to expand the lateral chambers 3010. This causes the IOL to flatten in shape.
  • Figures 18 and 19 show another embodiment of an IOL comprised of two or more pieces 3205a and 3205b that collectively form a fresnel lens region 3210.
  • the pieces each have a respective refractive index that can be the same or different from one another.
  • the two pieces When implanted in the eye, the two pieces are adapted to separate from one another, as shown in Figure 19 , or to move toward one another, as shown in Figure 18 , in response to zonular tension or lack thereof.
  • a space can form between the two pieces 3205a and 3205b wherein the material within the space has a refractive index different than the refractive index of the material from which the pieces are formed.
  • the change in refractive index effectively forms a lens between the two pieces of the 1OL.
  • the IOL can be manufactured using a variety of materials including, but not limited to silicone; silicone acrylate; acrylic; hydrogel (including urethanes, acrylamides, silicones, acrylics, polysaccharides, polyvinylpyrrolidones), poly(hydroxyethylmethacrylate), acrylonitrile (AN) copolymers; polyacrylonitrile (PAN) polymers; PAN homopolymers; hydrophilic co-monomers (including acrylamide, vinyl pyrrolidone, styrene sulfonic acid, vinylsulfonic acid etc.); hydrophilic polymers; hydrophobic co-monomers (including alkyl acrylates or methacrylates, styrene, vinylchloride, methylstyrene, vinylpyrridine etc.); hydrophobic polymers; and polymethylmethacrylate (PMMA).
  • silicone silicone acrylate
  • acrylic hydrogel (including urethanes, acrylamides, silicones, acrylic
  • the IOL can also be manufactured using a variety of methods and manufacturing processes.
  • the IOLs disclosed herein can be manufactured by shaping methods such as extrusion, casting, molding (including injection molding, compression molding, insert molding, etc.), dipping, spinning or similar shaping method.
  • the IOLs disclosed herein can also be shaped using micromachining techniques, such as with a femtosecond laser.
  • a solid hydrogel lens can be sliced or cleaved with a laser thereby forming internal planes and a desired shape within the IOL.
  • Other exemplary methods used in the manufacture and processing of IOLs are described in U.S. Patent Nos. 5,674,283 ; 4,971,732 ; 4,893,918 and 4,806,287 .
  • the IOLs disclosed herein can be placed in situ by a procedure in which an incision is made in the eye. After the incision is formed, the original lens can be removed from the eye. The IOL 205 or 2605 can then be positioned within the eye and the incision closed. Any suitable procedure, including procedures in which the original lens or a portion of the original lens is not removed, may be used.
  • the IOL 205 or 2605 can be used in conjunction with existing contacts, glasses, the natural lens, another IOL or any other suitable optical device, or the IOL 205 or 2605 can be used alone. Further, the IOL 205 or 2605 can be positioned in any suitable chamber (e.g., anterior or posterior) or within any suitable tissue or structure.
  • the IOL 205 or 2605 also can be attached to the existing or natural lens in any suitable manner, or the IOL 205 or 2605 can be detached from or replace the existing or natural lens.
  • Multilayer IOL designs such as IOL 205, having internal planes 210 arranged as a series of concentric spherical surfaces within the internal volume of the IOL, as shown in Figure 3 , were analyzed in isolation to characterize the optical power change-to-equatorial force relationship.
  • This analysis used nonlinear axissymmetric finite element modeling of a three-layer prototype.
  • Young's modulus (E elasticity modulus), defined as the ratio of tensile stress to tensile strain, describes tensile elasticity, or the tendency of an object to deform along an axis when opposing forces are applied along that axis.
  • the following table shows the different combinations of Young's modulus used for each of the five examples of three-layered IOLs.
  • the curvature per power ratio is based upon an aperture of 2.5 mm in diameter and a refractive index difference of 0.1.
  • Figure 21 shows the tabulated results for a solid, unlayered IOL and Models 1 through 5.
  • Figure 22 shows the vertical displacement contours (mm) for the solid section, Figure 23 for Model 1, Figure 24 for Model 2, Figure 25 for Model 3 and 5 , and Figure 26 for Model 4.
  • a solid, unlayered IOL is the reference point for the analysis. It is observed that power is independent of Young's modulus; but dependent on the Poisson ratio (bulk modulus). Since the solid, unlayered lens is incompressible (Poisson ratio ⁇ 0.5), its performance is fixed. The solid, unlayered IOL gives a power change of -1.434 D and a diopter to force ratio of 0.036 D/gram-force.
  • Model 5 is approximately 20 times more efficient than the solid section.
  • Model 5 offers a power change that is 2.86 times larger than the unlayered, solid IOL under a 0.3 mm radial displacement, while the zonular force required to achieve that displacement in Model 5 is 0.15 times that of the solid, unlayered IOL.
  • Figure 27 shows a graph of the IOL force versus radial displacement for Models 2 and 5. Model 2 requires more force for the same amount of displacement than Model 5.
  • Figure 28 shows a graph of the IOL force versus power change. For the same amount of radial force, Model 5 produces a lot more power change.
  • Figs. 29-30 are graphs showing comparing the IOL efficiency of Models 2 and 5; Model 5 is considerably more efficient in producing diopter changes than Model 2.
  • IOLs of the type used in Model 5 can be obtained in various ways.
  • a femtosecond laser can be used to morcellate the inner layers, to decrease their bulk modulus, while the Young's modulus of the outer layer remains high.
  • Another alternative method of producing an IOL of the Model 5 type involves using a silicone outer layer, while injecting silicone oil into a hollow inner layer. Silicone oil has the same refractive index as silicone polymer, and thus the visual acuity through these IOLs will not become compromised.
  • Another method of producing IOLs of the Model 5 type comprises molding an inner layer of low Young's modulus material, and then overmolding the subsequent layers on top of the initial inner layer.

Claims (4)

  1. Lentille oculaire (205, 2605), comprenant :
    un élément optique conçu pour être implanté en contact avec le sac capsulaire (130) d'un oeil humain (100), dans laquelle l'élément optique inclut une ou plusieurs chambres (3005, 3010) qui sont remplies avec un matériau qui change de forme en réponse aux forces agissant sur le matériau, dans laquelle l'élément optique est conçu pour être implanté de sorte que les une ou plusieurs chambres et le matériau qui remplit les une ou plusieurs chambres restent à l'intérieur de manière radiale de la zone équatoriale du sac capsulaire pendant le changement de forme.
  2. Lentille (205, 2605) selon la revendication 1, dans laquelle (i) le matériau est un matériau capable d'écoulement, ou (ii) dans laquelle le matériau est un liquide ou un gaz, ou (iii) dans laquelle le matériau comprend au moins un élément parmi l'air, la silicone, l'huile et l'hydrogel, ou (iv) dans laquelle le matériau de l'élément optique et le matériau dans les une ou plusieurs chambres (3005, 3010) ont des indices de réfraction qui sont substantiellement identiques de sorte que la réflexion de la lumière au niveau d'une interface des matériaux est minimisée ou éliminée, ou (v) dans laquelle les une ou plusieurs chambres (3005, 3010) incluent des chambres multiples et dans laquelle le matériau peut s'écouler d'une chambre à une ou plusieurs autres chambres en réponse à des stimuli, ou (vi) dans laquelle les plus d'une chambre (3005, 3010) incluent une chambre centrale (3005) et une ou plusieurs chambres latérales (3010) qui sont connectées de manière fluidique à la chambre centrale.
  3. Lentille (205, 2605) selon la revendication 2 (v), dans laquelle l'écoulement du matériau entre les chambres (3005, 3010) amène l'élément optique à subir un changement de forme.
  4. Lentille (205, 2605) selon la revendication 2 (vi), dans laquelle une majorité du matériau réside dans la chambre centrale (3005) quand la lentille est dans un état logé, et dans laquelle le matériau est un matériau facultativement capable d'écoulement qui s'écoule hors de la chambre centrale (3005) jusque dans les chambres latérales (3010) pour dilater les chambres latérales en réponse à des stimuli pour amener la lentille à prendre une forme aplatie.
EP08869938.4A 2008-01-03 2008-12-23 Lentille intraoculaire, d'accommodation. Not-in-force EP2237744B1 (fr)

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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4937997B2 (ja) 2005-03-30 2012-05-23 ニューレンズ・リミテッド 調節型眼内レンズ（ａｉｏｌ）アセンブリおよびそのための個別の構成要素
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
EP2237744B1 (fr) 2008-01-03 2018-04-04 Forsight Labs, Llc Lentille intraoculaire, d'accommodation.
CN101386203B (zh) * 2008-10-15 2011-09-14 广州卫视博生物科技有限公司 折叠式人工玻璃体制造方法及其模具
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
CN102883682A (zh) 2010-04-27 2013-01-16 雷恩斯根公司 调节眼内晶状体的装置
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
JP6009463B2 (ja) 2011-02-04 2016-10-19 フォーサイト・ビジョン６・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ６， Ｉｎｃ． 調節型眼内レンズ
US10080648B2 (en) 2012-01-24 2018-09-25 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US9364316B1 (en) 2012-01-24 2016-06-14 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
EP2806828B1 (fr) 2012-01-24 2021-07-21 The Regents of The University of Colorado, A Body Corporate Conceptions de lentilles intraoculaires modulaires et procédés s'y rapportant
US10028824B2 (en) 2012-01-24 2018-07-24 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
WO2014027689A1 (fr) * 2012-08-17 2014-02-20 Hoya株式会社 Élément de cristallin artificiel et cristallin artificiel
JP2014036770A (ja) * 2012-08-17 2014-02-27 Hoya Corp 眼内レンズ用部材及び眼内レンズ
JP2014036769A (ja) * 2012-08-17 2014-02-27 Hoya Corp 眼内レンズ用部材及び眼内レンズ
ES2457840B1 (es) 2012-09-28 2015-02-16 Universidad De Murcia Lente intraocular acomodativa de potencia variable y conjunto de lente intraocular acomodativa de potencia variable y anillo capsular
PT2911623T (pt) 2012-10-26 2019-11-21 Forsight Vision5 Inc Sistema oftálmico para libertação prolongada de fármaco no olho
US9220591B2 (en) 2012-12-21 2015-12-29 Abbott Medical Optics Inc. Accommodating intraocular lens providing progressive power change
US9186244B2 (en) 2012-12-21 2015-11-17 Lensgen, Inc. Accommodating intraocular lens
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
EP2976042B1 (fr) 2013-03-21 2023-09-13 Shifamed Holdings, LLC Mise en place de lentille intraoculaire
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
CN109806027A (zh) 2013-11-01 2019-05-28 雷恩斯根公司 双部件调节性人工晶状体设备
JP6625975B2 (ja) 2013-11-01 2019-12-25 レンスゲン、インコーポレイテッド 調節性眼内レンズデバイス
JP2017505702A (ja) 2014-02-18 2017-02-23 クラービスタ メディカル, インコーポレイテッドClarvista Medical, Inc. モジュール式眼内レンズの設計、器具および方法
AU2015236131B2 (en) 2014-03-28 2019-05-30 Forsight Vision6, Inc. Accommodating intraocular lens
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
CA3008944C (fr) 2014-08-26 2021-11-16 Shifamed Holdings, Llc Lentille intraoculaire adaptative
US10647831B2 (en) 2014-09-23 2020-05-12 LensGens, Inc. Polymeric material for accommodating intraocular lenses
EP3250152A1 (fr) 2015-01-30 2017-12-06 Clarvista Medical, Inc. Conceptions de lentille intraoculaire modulaire
EP3283004A4 (fr) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Composition d'insert oculaire d'agent pharmaceutiquement actif cristallin ou semi-cristallin
WO2017079449A1 (fr) 2015-11-04 2017-05-11 Clarvista Medical, Inc. Conceptions de lentilles intraoculaires modulaires, outils et procédés
EA038755B1 (ru) 2015-11-12 2021-10-14 Грейбаг Вижн, Инк. Агрегирующие микрочастицы для обеспечения замедленного высвобождения терапевтического агента для внутриглазной доставки
US11141263B2 (en) 2015-11-18 2021-10-12 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
WO2017096087A1 (fr) 2015-12-01 2017-06-08 Daniel Brady Dispositif de lentille intraoculaire d'adaptation
US11045309B2 (en) 2016-05-05 2021-06-29 The Regents Of The University Of Colorado Intraocular lens designs for improved stability
WO2017205811A1 (fr) 2016-05-27 2017-11-30 Thomas Silvestrini Huile pour lentille ayant une répartition étroite du poids moléculaire pour des dispositifs du type lentille intraoculaire
JP7074960B2 (ja) 2016-08-24 2022-05-25 カール ツァイス メディテック アーゲー デュアルモード調節型－非調節型眼内レンズ
CN110121313B (zh) 2016-10-28 2021-02-23 弗赛特影像6股份有限公司 可调节人工晶状体和植入方法
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
EP3375410A1 (fr) * 2017-03-13 2018-09-19 Kejako Sa Dispositif de lentille apte a l'accommodation
CA3055996A1 (fr) * 2017-03-13 2018-09-20 Kejako Sa Dispositif de lentille accommodative
CN111201040A (zh) 2017-05-10 2020-05-26 灰色视觉公司 用于医学疗法的缓释微粒及其悬浮液
US10987131B2 (en) 2017-05-25 2021-04-27 Coopersurgical, Inc. Tissue containment systems and related methods
AU2018277037B2 (en) 2017-05-30 2024-04-18 Shifamed Holdings, Llc Surface treatments for accommodating intraocular lenses and associated methods and devices
JP7082822B2 (ja) 2017-06-07 2022-06-09 シファメド・ホールディングス・エルエルシー 調整可能な屈折力の眼内レンズ
CN111065359A (zh) 2017-06-16 2020-04-24 埃斯库莱泰克股份有限公司 热反应性聚合物及其用途
US11382736B2 (en) 2017-06-27 2022-07-12 Alcon Inc. Injector, intraocular lens system, and related methods
US11357620B1 (en) 2021-09-10 2022-06-14 California LASIK & Eye, Inc. Exchangeable optics and therapeutics
WO2023069630A1 (fr) 2021-10-21 2023-04-27 Forsight Vision6, Inc. Système et procédés de remplissage de lentilles intraoculaires à accommodation avec un liquide
WO2024044312A1 (fr) 2022-08-25 2024-02-29 Forsight Vision6, Inc. Lentilles intraoculaires à perturbations photiques hors axe réduites

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356050A1 (fr) * 1988-08-15 1990-02-28 Storz Instrument Company Lentille intra-oculaire accomodable
WO2004046768A2 (fr) * 2002-11-20 2004-06-03 Powervision Systeme de lentille et procede de reglage de puissance
WO2004054471A2 (fr) * 2002-12-12 2004-07-01 Powervision Adaptation d'un systeme de lentille intra-oculaire et procede associe
WO2005084587A2 (fr) * 2004-03-03 2005-09-15 Akkolens International B.V. Deux elements optiques formant, en combinaison, une lentille de puissance optique variable destinee a etre utilisee en tant que lentille intraoculaire

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409691A (en) 1981-11-02 1983-10-18 Levy Chauncey F Focussable intraocular lens
US4971732A (en) 1984-06-28 1990-11-20 Ceskoslovenska Academie Ved Method of molding an intraocular lens
US4731078A (en) * 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
US4636210A (en) * 1985-12-09 1987-01-13 Hoffer Kenneth J Multi-part intraocular lens and method of implanting it in an eye
CS260213B1 (en) 1986-03-05 1988-12-15 Jiri Sulc Method of polymerization casting of articles especially lenses from hydrophilic gels and equipment for realization of this method
CS267858B1 (en) 1987-01-12 1990-02-12 Sulc Jiri Contact,if need be,intra-ocular lens and method of its production
US5236970A (en) 1987-02-05 1993-08-17 Allergan, Inc. Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses
US4842601A (en) 1987-05-18 1989-06-27 Smith S Gregory Accommodating intraocular lens and method of implanting and using same
US4782820A (en) 1987-10-22 1988-11-08 Woods Randall L Iris retaining device
US4888012A (en) 1988-01-14 1989-12-19 Gerald Horn Intraocular lens assemblies
US4994082A (en) 1988-09-09 1991-02-19 Ophthalmic Ventures Limited Partnership Accommodating intraocular lens
US4957505A (en) 1989-11-03 1990-09-18 Mcdonald Henry H Cannulated spring forceps for intra-ocular lens implantation method
US6197059B1 (en) 1990-04-27 2001-03-06 Medevec Licensing, B.V. Accomodating intraocular lens
US5476514A (en) 1990-04-27 1995-12-19 Cumming; J. Stuart Accommodating intraocular lens
US6423094B1 (en) 1991-11-18 2002-07-23 Faezeh M. Sarfarazi Accommodative lens formed from sheet material
US5275623A (en) 1991-11-18 1994-01-04 Faezeh Sarfarazi Elliptical accommodative intraocular lens for small incision surgery
US5344448A (en) * 1992-02-11 1994-09-06 Schneider Richard T Multi-focal intra-ocular implant
US5444106A (en) 1992-04-21 1995-08-22 Kabi Pharmacia Ophthalmics, Inc. High refractive index silicone compositions
US5480950A (en) 1992-09-28 1996-01-02 Kabi Pharmacia Ophthalmics, Inc. High refractive index hydrogels and uses thereof
US5316704B1 (en) 1992-09-28 1996-05-21 Kabi Pharmacia Ophthalmics Inc Process for fabricating full sized expansible hydrogel intraocular lenses
US6322589B1 (en) 1995-10-06 2001-11-27 J. Stuart Cumming Intraocular lenses with fixated haptics
WO1995021594A1 (fr) 1994-02-09 1995-08-17 Kabi Pharmacia Ophthalmics, Inc. Implantation rapide de lentilles optiques deformables
US5489302A (en) 1994-05-24 1996-02-06 Skottun; Bernt C. Accommodating intraocular lens
US6013101A (en) * 1994-11-21 2000-01-11 Acuity (Israel) Limited Accommodating intraocular lens implant
CZ282355B6 (cs) 1994-12-01 1997-07-16 Vladimír Ing. Csc. Stoy Implantovatelná oftalmická čočka, způsob její výroby a forma k provádění tohoto způsobu
ATE394080T1 (de) 1995-02-15 2008-05-15 Medevec Licensing Bv Anpassbare intraokulare linse mit t-förmigen haltebügeln
US5932205A (en) * 1997-07-24 1999-08-03 Wang; Ming X. Biochemical contact lens for treating photoablated corneal tissue
US6143315A (en) * 1997-07-24 2000-11-07 Wang; Ming X. Biochemical contact lens for treating injured corneal tissue
US6231603B1 (en) 1998-11-10 2001-05-15 Allergan Sales, Inc. Accommodating multifocal intraocular lens
US6176878B1 (en) 1998-12-17 2001-01-23 Allergan Sales, Inc. Accommodating intraocular lens
US7662179B2 (en) 1999-04-09 2010-02-16 Sarfarazi Faezeh M Haptics for accommodative intraocular lens system
US6790232B1 (en) 1999-04-30 2004-09-14 Advanced Medical Optics, Inc. Multifocal phakic intraocular lens
US6406494B1 (en) 1999-04-30 2002-06-18 Allergan Sales, Inc. Moveable intraocular lens
US6232406B1 (en) 1999-09-30 2001-05-15 Replication Medical Inc. Hydrogel and method of making
US6342073B1 (en) 1999-12-30 2002-01-29 J. Stuart Cumming Intraocular lens for posterior vaulting
FR2804860B1 (fr) * 2000-02-16 2002-04-12 Humanoptics Ag Implant cristallinien accomodatif
US6797004B1 (en) 2000-03-02 2004-09-28 Advanced Medical Optics, Inc. Holders for intraocular lenses
US6551354B1 (en) 2000-03-09 2003-04-22 Advanced Medical Optics, Inc. Accommodating intraocular lens
US7462194B1 (en) 2000-08-04 2008-12-09 Blake Larry W Two part “L”-shaped phakic IOL
US20040132131A1 (en) 2001-11-05 2004-07-08 Ofer Markman Methods for comparitive analysis of carbohydrate polymers and carbohydrate polymers identified using same
US6592621B1 (en) 2000-11-10 2003-07-15 Rudolph S. Domino Flexible intra-ocular lens of variable focus
US6818017B1 (en) 2001-02-15 2004-11-16 Stephen Shu High gain wide range accommodating intraocular lens for implant into the capsular bag
US6966049B2 (en) 2001-04-24 2005-11-15 Heuristics Physics Laboratories, Inc. Software development tool employing workflows for developing user interactive programs
US6533769B2 (en) 2001-05-03 2003-03-18 Holmen Joergen Method for use in cataract surgery
US6638305B2 (en) 2001-05-15 2003-10-28 Advanced Medical Optics, Inc. Monofocal intraocular lens convertible to multifocal intraocular lens
US6524340B2 (en) 2001-05-23 2003-02-25 Henry M. Israel Accommodating intraocular lens assembly
WO2003000154A2 (fr) 2001-06-22 2003-01-03 David Miller Lentilles intraoculaires d'accommodation ameliorees
US7118597B2 (en) 2001-06-22 2006-10-10 David Miller Accommodating intraocular lens
US6747090B2 (en) 2001-07-16 2004-06-08 Pharmacia Groningen Bv Compositions capable of forming hydrogels in the eye
US6884263B2 (en) 2001-07-17 2005-04-26 Medennium, Inc. Accommodative intraocular lens
US6443985B1 (en) 2001-08-27 2002-09-03 Randall Woods Intraocular lens implant having eye accommodating capabilities
US20070123982A1 (en) 2001-11-06 2007-05-31 Judith Yablonski Intra-ocular lens
EP1455690A1 (fr) 2001-11-30 2004-09-15 Medicel AG Appareil d'implantation d'une lentille intraoculaire
US7097660B2 (en) 2001-12-10 2006-08-29 Valdemar Portney Accommodating intraocular lens
AU2003210534A1 (en) 2002-01-14 2003-07-30 Advanced Medical Optics, Inc. Accommodating intraocular lens with integral capsular bag ring
US7150759B2 (en) 2002-01-14 2006-12-19 Advanced Medical Optics, Inc. Multi-mechanistic accommodating intraocular lenses
FR2835424B1 (fr) 2002-02-01 2004-11-26 Khalil Hanna Implant intracapsulaire accomodatif
US20050021139A1 (en) 2003-02-03 2005-01-27 Shadduck John H. Ophthalmic devices, methods of use and methods of fabrication
US6695881B2 (en) 2002-04-29 2004-02-24 Alcon, Inc. Accommodative intraocular lens
US7160324B2 (en) 2002-05-17 2007-01-09 Amo Groningen, B.V. Method in eye surgery
US20040034417A1 (en) * 2002-08-16 2004-02-19 Heyman Thomas M. Intraocular lens
US6972033B2 (en) 2002-08-26 2005-12-06 Advanced Medical Optics, Inc. Accommodating intraocular lens assembly with multi-functional capsular bag ring
US7018409B2 (en) 2002-09-13 2006-03-28 Advanced Medical Optics, Inc. Accommodating intraocular lens assembly with aspheric optic design
US20040082993A1 (en) 2002-10-25 2004-04-29 Randall Woods Capsular intraocular lens implant having a refractive liquid therein
US20040082995A1 (en) 2002-10-25 2004-04-29 Randall Woods Telescopic intraocular lens implant for treating age-related macular degeneration
US7381221B2 (en) 2002-11-08 2008-06-03 Advanced Medical Optics, Inc. Multi-zonal monofocal intraocular lens for correcting optical aberrations
US7320517B2 (en) 2002-12-06 2008-01-22 Visx, Incorporated Compound modulation transfer function for laser surgery and other optical applications
MXPA05006000A (es) 2002-12-06 2005-08-18 Visx Inc Correccion de presbiopia utilizando datos del paciente.
US7217288B2 (en) * 2002-12-12 2007-05-15 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US7341599B1 (en) 2003-04-09 2008-03-11 Minu, Llc Intraocular lens for correcting presbyopia
US20040237971A1 (en) 2003-06-02 2004-12-02 Hema Radhakrishnan Methods and apparatuses for controlling optical aberrations to alter modulation transfer functions
EP1682196A2 (fr) 2003-11-10 2006-07-26 Angiotech International Ag Implants medicaux et agents anti-cicatrisation
WO2005048882A1 (fr) * 2003-11-18 2005-06-02 Medennium, Inc. Lentille intra-oculaire accommodative et procede d'implantation
DE502004009370D1 (de) 2004-02-27 2009-05-28 Advanced Vision Science Inc Linsenaufnahme für eine vorrichtung zum einsetzen verformbarer intraocularlinsen
WO2005102223A1 (fr) 2004-04-22 2005-11-03 Advanced Vision Science, Inc. Dispositif pour introduire des cristallins artificiels deformables
US9713527B2 (en) 2004-04-30 2017-07-25 Rxsight, Inc. Multilens intraocular lens system with injectable accommodation material
NL1029037C2 (nl) 2005-05-13 2006-11-14 Akkolens Int Bv Verbeterde intra-oculaire kunstlens met variable optische sterkte.
US20070129800A1 (en) 2005-12-07 2007-06-07 C&C Vision International Limited Hydrolic accommodating intraocular lens
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
WO2007113832A2 (fr) 2006-04-03 2007-10-11 Isaac Lipshitz implant intraoculaire
GB0618262D0 (en) 2006-09-16 2006-10-25 Khoury Elie Accommodative intra-ocular lens
EP1932492B1 (fr) 2006-12-13 2011-09-14 Akkolens International B.V. Lentille intraoculaire accommodative dotée d'une correction variable
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
EP2237744B1 (fr) 2008-01-03 2018-04-04 Forsight Labs, Llc Lentille intraoculaire, d'accommodation.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356050A1 (fr) * 1988-08-15 1990-02-28 Storz Instrument Company Lentille intra-oculaire accomodable
WO2004046768A2 (fr) * 2002-11-20 2004-06-03 Powervision Systeme de lentille et procede de reglage de puissance
WO2004054471A2 (fr) * 2002-12-12 2004-07-01 Powervision Adaptation d'un systeme de lentille intra-oculaire et procede associe
WO2005084587A2 (fr) * 2004-03-03 2005-09-15 Akkolens International B.V. Deux elements optiques formant, en combinaison, une lentille de puissance optique variable destinee a etre utilisee en tant que lentille intraoculaire

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EP2237744A2 (fr) 2010-10-13
WO2009088448A2 (fr) 2009-07-16
US20090292355A1 (en) 2009-11-26
US8167941B2 (en) 2012-05-01
US20120168422A1 (en) 2012-07-05
EP3381407A1 (fr) 2018-10-03
WO2009088448A3 (fr) 2010-04-15

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