EP2191894A1 - Réservoir de soufflet à plis pour microsystèmes - Google Patents

Réservoir de soufflet à plis pour microsystèmes Download PDF

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Publication number
EP2191894A1
EP2191894A1 EP08169958A EP08169958A EP2191894A1 EP 2191894 A1 EP2191894 A1 EP 2191894A1 EP 08169958 A EP08169958 A EP 08169958A EP 08169958 A EP08169958 A EP 08169958A EP 2191894 A1 EP2191894 A1 EP 2191894A1
Authority
EP
European Patent Office
Prior art keywords
vessel
bellows
recess
opening portion
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08169958A
Other languages
German (de)
English (en)
Inventor
Thomas Voit
Bruno Monschau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen GmbH
Original Assignee
Qiagen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qiagen GmbH filed Critical Qiagen GmbH
Priority to EP08169958A priority Critical patent/EP2191894A1/fr
Priority to PCT/EP2009/065081 priority patent/WO2010060807A1/fr
Priority to CN2009801456517A priority patent/CN102215968A/zh
Priority to JP2011537924A priority patent/JP2012509730A/ja
Priority to US13/130,214 priority patent/US20120024417A1/en
Publication of EP2191894A1 publication Critical patent/EP2191894A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers

Definitions

  • the invention relates to a storage and dispensing vessel used in a microsystem and to a method of storing and dispensing a liquid to be used in a microsystem.
  • a microsystem is a device that handles small volumes of fluid, for example, to perform chemical or biological analyzes. Such a microsystem therefore includes channels of small diameters. Conventional are diameters of not more than 1 mm, in particular of not more than 150 ⁇ m,
  • the buffer solutions contain on the one hand regularly alcohol, such as ethanol, Such buffer solutions may also contain crawling substances such as salt solutions.
  • Buffer solutions for microsystems are needed only in small quantities of, for example, only one milliliter. Since only very much larger quantities can be produced economically from one liter, there is a need to replenish a prepared amount of buffer solution of, for example, one liter into very small vessels of, for example, one milliliter. Since some buffer solutions are rarely needed, the vessels to which the produced quantity has been transferred for storage must be designed to be stored for several months and even years.
  • a syringe is generally not sufficiently tight to allow very long storage times.
  • syringes are preferably stored at temperatures of, for example, 4 ° C. for the purpose of extending a storage time, it is not possible to achieve storage times of, for example, two years.
  • storing a syringe at 4 ° C is relatively expensive because refrigerators must be provided for storage.
  • a buffer solution is filled into a vessel, which is then sealed by welding or sealing.
  • a defined amount is taken from such a welded vessel with a syringe and then released again defined,
  • Such a process is relatively complex, A removal and delivery with a syringe can be carried out automatically only with a disproportionate technical effort.
  • a device for receiving and dispensing saliva is known.
  • a sample of saliva is taken up by a bellows designed as a vessel. By compressing the bellows, a previously taken sample is released again.
  • the vessel known therefrom is neither intended nor suitable for storing volatile or creeping-containing solutions for long periods of at least several months ,
  • the object of the invention is to store a fluid with volatile and / or creeping substances in very small vessels over many months, preferably over at least one year and be able to deliver automated with a relatively low technical effort.
  • a bellows designed as a vessel which is closed air-tight and liquid-tight, once the bellows vessel has been filled.
  • This bellows vessel serves as a storage vessel and at the same time as a dispensing vessel.
  • the vessel can be emptied automatically with relatively simple means , For this purpose, it is clamped in a device, for example, which compresses the bellows and in the direction of a hollow needle - also called cannula or injection needle - or a comparable agent.
  • the hollow needle or similar means pierces a vessel wall or the lid of the vessel, About the hollow needle or similar means then the vessel is automatically emptied. Since only a linear movement has to be created for emptying, it is technically relatively easy to enable an automated emptying.
  • bellows are used for metering as part of a delivery vessel according to the prior art.
  • such vessels are not filled until shortly before use, so these are not used as a storage vessel to keep a fluid therein for several months or even for example two years in it.
  • vessels with a bellows which are known from the prior art are therefore not welded closed or sealed in a comparable manner.
  • the vessels known from the prior art, which are provided with a bellows have no volumes of at most 2 ml, preferably of a maximum of 1 ml, If the vessel volume is too large and at the same time relatively long, the bellows becomes too unstable to be able to empty the vessel reliably with technically simple means.
  • a bellows Compared to a tube, a bellows has the advantage that the vessel can be emptied defined with comparatively simple technical means. Compared to a syringe in which a piston is moved in a cylindrical vessel for emptying, a bellows vessel in the sense of present invention has the advantage of improving the seal to ensure outward. Significantly longer storage times are made possible.
  • Such a bellows container has, in one embodiment of the invention, a bottom portion and an opening portion.
  • the floor area is provided with a depression or a pin which extends into the interior of the vessel.
  • the wall area between the floor area and the opening area is completely equipped as a bellows. If the bellows is completely compressed, there remains a distance between the bottom region and the opening region, since the bellows can not be compressed to 0 mm.
  • the depression or pin now extends in the direction of the opening region and ideally achieves this when the bellows has been compressed in the maximum possible way. This ensures that the vessel can be correspondingly more completely emptied if the opening area is pierced with the aid of a hollow needle or a comparable means,
  • the bottom area has a depression
  • this depression can be used to clamp the vessel particularly easily in an automated emptying device.
  • a provided in the device plug, pin or bolt can then be pushed into the recess.
  • the bellows is suitably securely held in such an automated, metered emptying dispenser and safely guided during the compression of the bellows,
  • the opening area of the bellows vessel preferably comprises a neck in one embodiment.
  • the neck serves as a guide for a hollow needle.
  • the vessel can be reliably and easily kept and clamped at the side of the opening area in a technically simple device for automated, metered emptying.
  • the aforementioned pin or recess in the bottom region is then preferably dimensioned such that the pin or depression reaches the neck or even reaches into the neck.
  • the aforementioned neck opens into a laterally outwardly projecting collar.
  • a tool can then grab behind the collar and press against a lid, while welding lid with collar or glue.
  • This geometry thus makes it possible to fill the vessel via the neck and then seal it in a fluid-tight manner in a simple manner by welding.
  • the vessel is then completely sealed to the outside by cohesive connections,
  • the lid with which the vessel is sealed fluid-tight, has a depression or a pin in the direction of the interior of the vessel.
  • the dead volume is further minimized, for example in the neck area.
  • the pin or the recess of the lid may be provided alternatively or in addition to a pin or a depression at the bottom area in order to minimize dead volumes.
  • the diameter of the webs or recesses is preferably selected so that the webs or recesses close to the bellows, so as to further minimize adverse dead volumes.
  • the collar or the neck of the vessel sit in an embodiment of the invention in a recess in the device for automated delivery and are thus reliably fixed, at the same time then extends this recess of the lid, for example, a round, hollow, made of plastic or metal needle, the is preferably bevelled in the direction of the vessel in order to easily pierce the lid when the contents of the vessel to be dispensed.
  • a round, hollow, made of plastic or metal needle the is preferably bevelled in the direction of the vessel in order to easily pierce the lid when the contents of the vessel to be dispensed.
  • the round, tubular hollow needle through the buffer solution or otherwise contained therein fluid can flow after piercing the lid.
  • the closure or the lid of the vessel has one or more latching projections on an inner wall of a depression into which the needle is pushed.
  • the needle is guided very accurately and reliably in the depression, Operating errors and the like are avoided so particularly reliable.
  • such a latching projection is dimensioned such that it serves as a stop for the hollow needle when the vessel is clamped or fastened in an apparatus for automated emptying or for automated dispensing.
  • the needle then abuts first against the locking projection and so on a certain resistance. It is thus avoided that the needle prematurely pierces the closure.
  • the needle can pass through the corresponding locking projection only with greater force and pierce the closure or the lid in the intended manner.
  • locking projection and needle are coordinated so that upon reaching the stop the locking projection also acts as a seal to create a liquid-tight connection between the needle and the vessel.
  • the vessel may be provided with an annular recess, for example, snaps into a protruding, in particular annular bead, which is present on the outer circumference of the needle.
  • the automated emptying vessel may include at the bottom of a clamped vessel a plunger or pin which engages a recess at the bottom of the vessel and which then exerts the necessary force to compress the bellows for emptying.
  • a plunger or pin which engages a recess at the bottom of the vessel and which then exerts the necessary force to compress the bellows for emptying.
  • the dispenser may have a plurality of such needles together with plungers and so on to simultaneously clamp and empty several vessels. However, it can then be automatically emptied one after the other vessel by vessel automatically when the corresponding bellows vessels have been inserted into the dispenser.
  • injection blow molding can be used.
  • a preform is first produced by injection molding. Subsequently, this preform is brought into a final shape having the Faltenbalgform. The preform is heated and then blown into the mold so as to slip the then heated plastic into the actual mold.
  • a multi-component injection molding process is performed.
  • the individual areas of the bellows vessel are thus injected in sections.
  • Different plastic materials can be used as needed.
  • the closure is injected immediately in the context of such an injection molding process.
  • the vessel is then filled from the bottom area and the floor is then welded or glued shut.
  • the actual outlet opening can be used for filling, and then, as indicated, a closure is welded on.
  • FIG. 1 shows in section a vessel with a volume of 1 ml with a bellows 1, a bottom portion 2 and an opening portion formed by a neck 3.
  • the neck opens into an outwardly projecting collar 4 a.
  • the bottom area is provided with a recess 5.
  • a plunger, pin or the like of a device for automatic emptying of the vessel can be inserted into the recess 5 to clamp the bottom portion 2 in such a device and to guide the bottom during the compression of the bellows.
  • the depression 5 further contributes to the complete emptying of the vessel for reasons mentioned above,
  • FIG. 2 an associated closure or lid for the vessel is shown in section, the lid has also for reasons already mentioned a recess 6 and a latching projection 7.
  • the annular edge region 8 of the lid is welded or glued to the collar 4 so as to reliably close the container tightly.
  • FIG. 3 shows the sealed vessel, a hollow needle punctured for emptying recess 6 of the lid. The bellows is then fully compressed.
  • such a vessel can be emptied in this way to 80% with an accuracy of +/- 5%, In this sense succeeds a sufficiently accurate dosage of the amount of discharged fluid.
  • the vessel and lid are made in particular of plastic, such as polypropylene.
  • Thermoplastics are basically preferred for manufacturing reasons.
  • the hollow needle may be made of plastic, metal, glass or a ceramic.
  • annular locking projection 7 may be present instead of an annular recess or groove.
  • the hollow needle points to the removal is provided by liquid, a corresponding annular outwardly projecting locking projection.
  • the needle may also be provided with an annular groove into which an annular catch projection of the vessel engages in order not only to provide a stop, but also to effect a liquid-tight connection at the same time.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
  • Micromachines (AREA)
EP08169958A 2008-11-26 2008-11-26 Réservoir de soufflet à plis pour microsystèmes Withdrawn EP2191894A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08169958A EP2191894A1 (fr) 2008-11-26 2008-11-26 Réservoir de soufflet à plis pour microsystèmes
PCT/EP2009/065081 WO2010060807A1 (fr) 2008-11-26 2009-11-13 Réservoir de soufflet pour microsystèmes
CN2009801456517A CN102215968A (zh) 2008-11-26 2009-11-13 用于微系统的波纹管型储器
JP2011537924A JP2012509730A (ja) 2008-11-26 2009-11-13 マイクロシステム用ベローズ型貯留槽
US13/130,214 US20120024417A1 (en) 2008-11-26 2009-11-13 Bellows-Type Reservoir For Microsystems

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08169958A EP2191894A1 (fr) 2008-11-26 2008-11-26 Réservoir de soufflet à plis pour microsystèmes

Publications (1)

Publication Number Publication Date
EP2191894A1 true EP2191894A1 (fr) 2010-06-02

Family

ID=40568675

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08169958A Withdrawn EP2191894A1 (fr) 2008-11-26 2008-11-26 Réservoir de soufflet à plis pour microsystèmes

Country Status (5)

Country Link
US (1) US20120024417A1 (fr)
EP (1) EP2191894A1 (fr)
JP (1) JP2012509730A (fr)
CN (1) CN102215968A (fr)
WO (1) WO2010060807A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017021513A1 (fr) * 2015-08-04 2017-02-09 Benjamin Ohmer Procédé de moulage par coulée au moyen d'un liquide dilatant, installation pour fabriquer un objet tridimensionnel et corps creux présentant une contre-dépouille

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2486677A (en) * 2010-12-22 2012-06-27 Agilent Technologies Inc Ceramic injection needle for analysis system
CN102874456A (zh) * 2012-09-28 2013-01-16 林明茳 重压式自动出水盛水容器

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333075A2 (fr) * 1988-03-16 1989-09-20 Fuji Photo Film Co., Ltd. Récipient pour produit de traitement
DE3800667C2 (fr) 1988-01-13 1990-07-05 Rudolf Brand Gmbh + Co, 6980 Wertheim, De
US5409117A (en) * 1994-04-13 1995-04-25 Kvm Technologies, Inc. Liquid specimen vessel
DE19608110A1 (de) * 1996-03-02 1997-09-04 Undine Dr Soltau Probenbehältnis
DE19748331C1 (de) 1997-10-31 1999-01-28 Primed Medizintechnik Gmbh Vorrichtung zur Aufnahme und Abgabe von Speichel
DE19922285A1 (de) * 1999-05-14 2000-11-16 Febit Ferrarius Biotech Gmbh Probengefäß
WO2005022729A1 (fr) 2003-08-29 2005-03-10 Seiko Precision Inc. Actionneur electromagnetique

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3800667C2 (fr) 1988-01-13 1990-07-05 Rudolf Brand Gmbh + Co, 6980 Wertheim, De
EP0333075A2 (fr) * 1988-03-16 1989-09-20 Fuji Photo Film Co., Ltd. Récipient pour produit de traitement
US5409117A (en) * 1994-04-13 1995-04-25 Kvm Technologies, Inc. Liquid specimen vessel
DE19608110A1 (de) * 1996-03-02 1997-09-04 Undine Dr Soltau Probenbehältnis
DE19748331C1 (de) 1997-10-31 1999-01-28 Primed Medizintechnik Gmbh Vorrichtung zur Aufnahme und Abgabe von Speichel
DE19922285A1 (de) * 1999-05-14 2000-11-16 Febit Ferrarius Biotech Gmbh Probengefäß
WO2005022729A1 (fr) 2003-08-29 2005-03-10 Seiko Precision Inc. Actionneur electromagnetique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017021513A1 (fr) * 2015-08-04 2017-02-09 Benjamin Ohmer Procédé de moulage par coulée au moyen d'un liquide dilatant, installation pour fabriquer un objet tridimensionnel et corps creux présentant une contre-dépouille

Also Published As

Publication number Publication date
JP2012509730A (ja) 2012-04-26
WO2010060807A1 (fr) 2010-06-03
CN102215968A (zh) 2011-10-12
US20120024417A1 (en) 2012-02-02

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