EP2480271A2 - Contenant scellé pourvu d'un piston coulissant - Google Patents

Contenant scellé pourvu d'un piston coulissant

Info

Publication number
EP2480271A2
EP2480271A2 EP10757559A EP10757559A EP2480271A2 EP 2480271 A2 EP2480271 A2 EP 2480271A2 EP 10757559 A EP10757559 A EP 10757559A EP 10757559 A EP10757559 A EP 10757559A EP 2480271 A2 EP2480271 A2 EP 2480271A2
Authority
EP
European Patent Office
Prior art keywords
seal
container
base body
opening
piston
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10757559A
Other languages
German (de)
English (en)
Inventor
Andy Greter
Mathey Vukic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Systems AG
Original Assignee
Medmix Systems AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medmix Systems AG filed Critical Medmix Systems AG
Publication of EP2480271A2 publication Critical patent/EP2480271A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3121—Means preventing contamination of the medicament compartment of a syringe via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end

Definitions

  • the present invention relates to a container having a base body, in the interior of which a piston is displaceably arranged.
  • Such containers are referred to below as syringe-like containers.
  • a normal disposable hypodermic syringe comprises a hollow, cylindrical syringe body made of plastic, in which a piston is slidably disposed.
  • the piston is usually fixedly connected to a piston rod which extends in the proximal direction of the syringe body out.
  • an actuating flange is formed, and the syringe body are usually formed opposite two retaining flanges.
  • the syringe is held between forefinger and middle or ring finger. The thumb is used to apply pressure to the actuation flange to expel an in-syringe product through a distal outlet port.
  • the corresponding counterforce is absorbed by the retaining flanges.
  • multiple syringes are also known, comprising two or more parallel or concentrically arranged, interconnected syringe body, in which two or more identical or different components are received and from which the components can be discharged by displacement of corresponding pistons.
  • These components may be, for example, two different components of a pharmaceutical product, which are not immediately before Administration, or two or more components of a bone cement.
  • two or more components of a medical or non-medical adhesive for example a medical adhesive based on fibrin.
  • Many other applications of multiple syringes are known or conceivable.
  • Such multiple syringes are adapted to be connected to a mixer to mix the ejected components immediately after leaving the multiple syringe.
  • the pistons are often connected to each other via a common actuator.
  • Syringe-like containers also find application in the form of cartridges for special dispensers. In this case, the outer shape of the container is often adapted for use in a particular dispenser.
  • a dispenser with a cartridge for two components is disclosed, for example, in WO 2008/009143.
  • the product may be, for example, a volatile, aggressive, hygroscopic or oxygen-sensitive substance.
  • the product may be, for example, a volatile, aggressive, hygroscopic or oxygen-sensitive substance.
  • many commercial plastics for example, the commonly used polyethylene, have a relatively high permeability and therefore form an insufficient barrier to diffusion of ingredients from the inside of the container to the outside or foreign matter such as water or volatiles and gases from the outside of the container to the inside. In a container of such a plastic stored products can thereby change their properties during prolonged storage in an undesirable manner.
  • glass syringes are often used because glass is practically impermeable to all common substances.
  • EP 1 486 584 a plastic tube is disclosed which has an open end and is closed at this end by a stopper. A continuous coating surrounds both the tube and the plug. It is therefore not possible to fill the tube without breaking the coating.
  • a syringe made of plastic is provided, which is provided with a diffusion-reducing coating.
  • a cap is attached, which is removed before discharging.
  • the diffusion-tightness of such a syringe can be further improved.
  • the present invention also relates to a method of manufacturing a container having a product therein, the method having the features of claim 14.
  • a container which comprises a hollow basic body with an inner, with an outer side, with a distal outlet opening and with a proximal actuating opening, wherein the actuating opening is suitable and intended to introduce an actuating element into the interior of the basic body.
  • a piston is slidably disposed to one inside the Main body between piston and Auslassöffiiung existing flowable product out of the container.
  • the base body has a diffusion-reducing barrier layer
  • the outlet opening is closed by a first separable and / or removable, in particular peelable, seal
  • the actuating opening is characterized by a second soutrermbares and / or removable, in particular peelable, Sealed seal.
  • the first seal is preferably applied cohesively to a first bearing surface surrounding the first outlet surface
  • the second seal is preferably applied cohesively to a second Auslassöffiiung surrounding second bearing surface.
  • a container which on the one hand has a very low permeability for light molecules through the container wall and thus an improved diffusion tightness.
  • a gas or liquid exchange through the Auslassöffiiung or through a sealing gap between the piston and the container wall and further through the actuating opening due to the seal is also prevented or at least greatly reduced.
  • such a container is suitable for longer-term storage of the product contained in the container. If the product is to be discharged from the container, the seals can be easily severed or removed, e.g. by piercing or pulling off.
  • the product received in the container may be any flowable product which is compatible with the material of the body, in particular a liquid, suspension or emulsion, gel, paste or other form of high viscosity flowable product, a powder, etc.
  • the product is received in a product receiving area of the container, which is preferably immediately bounded by the main body, the piston and the first seal, ie between the product and the main body, the piston and the first seal is no further envelope.
  • the container is thus opened immediately for a product discharge by the first seal is severed or removed.
  • Such an additional closure is then preferably located within that region of the container which is closed by the first seal, so that the first seal diffuses through the additional seal Closure alone could still take place, effectively reduced.
  • the diffusion-reducing barrier layer is preferably applied to the outside of the container. It can be combined with one or more further layers, e.g. a protective layer, be provided. But it can also be present on an inner side of the container.
  • the thickness of the barrier layer is preferably about 20 nanometers to 20 micrometers.
  • the barrier layer may e.g. from a diffusion-reducing polymer, e.g. Polyparaxylylene (parylene) prepared by suitable methods, e.g. by chemical vapor deposition (CVD), is applied to the surface of the container.
  • the barrier layer preferably contains a metal or a metal compound and preferably consists essentially completely of a metal or a metal compound.
  • the metal of the barrier layer may in particular be selected from the following metals and their alloys: aluminum, titanium, chromium, silver and copper. Aluminum is preferred.
  • a barrier layer may be applied to the base by any known method, e.g. by physical vapor deposition (PVD) or chemical vapor deposition (CVD). Suitable coating methods are known in the art. In particular, reference is made to the already mentioned publications WO 2006/085063 and EP 1 486 584 as well as the prior art relating to coating methods discussed therein.
  • the first and the second seal are sealingly attached (sealed) over the respective opening on the base body, in particular adhesively bonded or welded (for example by laser welding, ultrasonic welding or other known methods).
  • the barrier layer and the seals overlap in the region in which the respective seal is applied, ie at least one of the seals is preferably applied directly or indirectly to the barrier layer of the base body.
  • the first and / or second seal can be inductively sealed onto the corresponding support surface.
  • the seal comprises at least one electrically conductive layer and at least one thermoplastic adhesive layer. The seal is pressed onto the relevant bearing surface and exposed to an electromagnetic alternating field, which induces eddy currents in the conductive layer.
  • the respective bearing surface, to which the first or second seal is applied in a material-locking manner preferably extends transversely, in particular perpendicular to the longitudinal direction.
  • a transverse to the longitudinal direction inwardly or outwardly extending support flange may be formed, which increases the support surface for the respective seal.
  • Each of the seals preferably consists of a relatively thin, flat material, wherein the two seals may consist of the same or of different materials.
  • the seals are preferably thin, especially with respect to the area covered by the seal, with a thickness of less than 1/10 of the extent perpendicular to the thickness, and preferably thinner than 1 mm.
  • the seals are thinner than the side wall portion of the base body in which the piston is displaceable.
  • the seals may e.g. be formed in the form of a single or multi-layered film or be formed by a laminate of several layers, wherein a layer facing away from the openings, e.g. a carrier layer of paper or cardboard can be.
  • each of the seals preferably comprises at least one barrier layer.
  • the barrier layer basically the same considerations apply as for the barrier layer of the body.
  • the barrier layer may also consist of a diffusion-reducing polymer or preferably contain a metal or a metal compound or consist essentially of a metal or a metal compound.
  • the barrier layer preferably consists of a metal, in particular aluminum.
  • the barrier layer is preferably not produced by CVD or PVD methods, but conventionally, for example, by laminating an aluminum layer to a suitable carrier material.
  • Each of the seals can also be made entirely of metal.
  • One or each of the seals may have a weakening area, eg a perforation, to facilitate the severing.
  • each of the seals may have a tab for peeling off the seal.
  • This tab may be formed protruding from the body to facilitate gripping the tab.
  • the coating, the first seal and the second seal together preferably cover at least 90% of the base body, in particular its outer side. Preferably, the outside is completely covered by the coating and the seals.
  • the piston is displaceable in the main body in a cylindrical wall region.
  • the direction in which the piston is displaceable defines a longitudinal direction.
  • the base body may, in some embodiments, comprise at least one flange extending transversely to the longitudinal direction and located in the region of the actuating opening, which flange may in particular serve to hold the container with respect to the longitudinal direction during discharge.
  • the container may take on an actual syringe shape. If such a flange is present, it is preferable if it is aligned on its proximal side with that portion of the body which defines the Betrelifactsöffiiung, and when the second seal is applied to the flange, i. at the same time as the retaining flange serves as a proximal bearing flange for the second seal. In this way, the bonding area between the container and the seal is increased.
  • the container can accommodate a single product or several separate products.
  • the container may have at least one second hollow base body connected to the first base body, with an interior, with an outside, with a distal second outlet opening and with a proximal second actuation opening.
  • a second piston may be arranged displaceably in the interior of the second basic body in order to discharge a second product present in the interior of the second basic body from the container.
  • Both the first basic body and the second basic body then preferably have on their outer side a (preferably common) diffusion-reducing coating, and the second outlet opening and the second actuating opening are likewise closed by a respective removable or puncturable seal.
  • the first outlet opening and the second outlet opening may be closed together by the first seal, and the first actuating opening and the second actuating opening may be jointly closed by the second seal.
  • the inventive container can be supplemented by an actuator to a discharge. The actuator is then adapted to cooperate with the piston inside the body to discharge the product from the container.
  • the actuating element may comprise at least one separating element, which is adapted to sever the second seal.
  • the separating element can be, for example, a cutting element, a piercing element or a combination of such elements.
  • the actuating element may comprise a ram extending along a longitudinal direction.
  • This plunger is then designed to cooperate at its distal end with a proximal rear side of the piston.
  • the separating element may then comprise a cutting edge arranged in an outer edge region of the distal end, which is designed to sever the second seal in an area immediately adjacent to the basic body. This ensures a clean separation.
  • a complete discharge device further comprises a container holder which at least partially accommodates at least one container of the type specified above.
  • the container holder then preferably has a piercing element for the first seal in order to sever the first seal in the distal direction during insertion of the container into the container holder or during movement in the container holder.
  • this can be a hollow piercing element that forms a fluid channel in order to guide the product contained in the container to a receiving opening of the container holder.
  • the piercing element can be formed like a spike.
  • On the container holder in the region of the removal opening, there is preferably a connection structure for connecting an accessory, e.g. a cannula, a mixer or a spray head formed.
  • a method according to the invention for producing a container comprises the following steps:
  • FIG. 1 shows a highly schematically illustrated container in the form of a single syringe according to a first embodiment of the invention
  • Fig. 2 is a highly schematically illustrated container with alternative
  • FIG. 3 is a highly schematically illustrated container in the form of a double syringe according to a second embodiment of the invention.
  • FIG. 4 shows a discharge device according to a third embodiment of the
  • FIG. 5 shows a container according to FIG. 4 in a perspective view
  • FIG. 6 shows the container of Figure 5 in a perspective sectional view ..
  • FIG. 7 shows the discharge device of FIG. 4 in an exploded view
  • FIG. 9 shows the discharge device of FIG. 4 after discharge of the contents in FIG central longitudinal section.
  • FIG. 1 illustrates a first embodiment of a container 100 in a highly schematic form.
  • a hollow, cylindrical main body (syringe body) 110 has an outlet opening 111 in a tapered distal end area and an actuating opening 113 at the opposite proximal end.
  • a circumferential, radially outwardly projecting flange 112 is formed in order to be able to better hold the syringe body 110 in the axial direction.
  • This flange is aligned at its proximal side with that portion of the syringe body which surrounds the Bettechnik institutesöffiiung 113.
  • a piston 120 is slidably disposed in the syringe body 110.
  • the piston 120 is sealed by an O-ring 121 against the inside of the wall of the syringe body 110.
  • the syringe body 110 has on its outer side a coating in the form of a metallic barrier layer 140, which extends over the entire surface of the outside of the syringe body to the openings 111, 113.
  • the coating may be applied by any known method.
  • a first seal 150 is applied, eg welded or glued.
  • the syringe body 110 together with the first seal 150 and the piston 120, directly delimits a product area (product reservoir) in which there is a flowable product 130, eg PMMA, bone cement or another chemically aggressive, volatile or oxygen-sensitive substance.
  • a second seal 160 covers the Betuschistsöffiiung 113 and here also the flange 112. Both seals each contain a metallic barrier layer. Both seals overlap in the area in which they are applied to the base body, with the coating, ie the seals are directly connected to the coating. Due to the coating and the seals, the container 100 is hermetically sealed and protected against harmful diffusion processes. In particular, protection against the effects of diffusion through the sealing point between the piston 120 and the container wall is ensured.
  • the thickness of the coating 140 and the seals 150, 160 is not to scale and greatly exaggerated in FIG. 1 for illustrative purposes shown. It can also be coated only one of the syringe body.
  • the first seal 150 is removed or severed. For this it is e.g. pierced by means of an accessory, not shown, which is attached to the outlet and having a hollow mandrel. This immediately opens the container at the outlet.
  • the second seal 160 is removed or pierced. This can be done in particular with the actuator 200 also shown in FIG. 1.
  • This has the shape of a plunger, which has a piston rod 210. At the proximal end of the plunger an actuating flange 211 is formed. At the distal end, the plunger has an end portion 212, which is formed in its shape complementary to the proximal end of the piston 120.
  • a peripheral cutting edge is formed, which serves to sever the second seal 160 immediately upon insertion of the ram into the container 100 directly in the region of the container wall.
  • FIG. 1 An alternative embodiment of the seals is illustrated in FIG.
  • the first seal 150 and the second seal 160 here each have a tab 151 or 161, which serves to remove the seal from the respective opening.
  • FIG. 3 illustrates a second embodiment in a highly schematic form, in which the container 100 'is designed as a double syringe. Equivalent parts are designated by the same reference numerals as in FIG. 1.
  • a second syringe body 110 ' arranged parallel thereto is present, with a second outlet opening 111' and a second actuating opening 113 '.
  • a second piston 120 ' is arranged, which defines a second product receiving area for a second product 130' together with the syringe body.
  • the two syringe bodies 110, 110 ' are rigidly connected to each other via a material bridge, not shown in FIG. They are provided together with a coating 140.
  • a mixer 300 is connected in a fastening region 312 to the container 100 '.
  • the mixer 300 has a mixing tube 310 with a static mixing element 320 and two feeders 311.
  • the actuation of the pistons 120, 120 ' takes place by means of an actuating element 200' in the form of a double piston, with a first piston rod 210 and a second piston rod 210 ', which are connected via a common actuating flange 211'.
  • the double plunger can in turn have cutting elements. If the two products are discharged from the two syringe bodies by pressure on the double plunger, they pass into the mixer 300 and are mixed together there. The mixture then exits the mixer at a mixer outlet 313.
  • a third embodiment of the present invention is illustrated in various views, in which containers of the type indicated above are inserted as a kind of interchangeable cartridge in a discharge device.
  • the discharge device shown here comprises two containers 100, which are shown alone in Figures 5 and 6, a container holder 400 and an actuator 430, which is shown only in FIG. 9.
  • Like-acting parts are designated by the same reference numerals as for the first and second embodiments.
  • Each of the containers 100 in turn comprises a hollow base body 110 made of plastic, which has on its outer side a diffusion-reducing coating not shown in FIGS. 4-9.
  • the main body has a cylindrical side wall region, to which a taper 114 adjoins in the region of the distal end of the container.
  • a radially outwardly projecting first, distal support flange 115 is formed, which surrounds the outlet opening 111 radially.
  • a radially outwardly projecting second, proximal support flange 112 is formed, which radially surrounds the proximal actuation opening 113.
  • a piston 120 which is displaceable along a longitudinal direction and with a circumferential seal 121 is arranged.
  • the distal outlet opening 111 is in turn closed by a first seal 150.
  • the first support flange 115 forms a first support surface extending perpendicular to the longitudinal direction, on which the seal 150 is applied in a material-locking manner.
  • the proximal end of the main body 110 is closed by a second seal 160.
  • the second support flange 112 forms a second support surface extending perpendicular to the longitudinal direction, to which the second seal 160 is applied in a material-locking manner.
  • the container holder 400 has two parallel, cylindrical receiving regions 410 into which the two containers are inserted from the proximal side.
  • an insert 420 is used, on which a mandrel-like piercing element 421 pointing in the proximal direction is formed.
  • the piercing element 421 is hollow and, together with the rest of the insert, defines a fluid channel 422 which opens into a respective removal opening 415 (FIG. 7) of the container holder.
  • the discharge device also comprises an actuating element 430 in the form of a double pestle.
  • the actuating element forms a piston rod 431 for each of the two pistons 120, at the distal end of which a feed flange 432 is formed, which cooperates with the respective piston 120.
  • the two piston rods 431 are interconnected by a common actuating flange 433.
  • the two containers 100 are disposed with their respective distal ends spaced from the respective piercing member 421, and the respective first seals 150 are still intact.
  • a (not shown) latching element may be present to hold the respective container in this storage position in a releasable latching connection.
  • the user first inserts the two containers 100 in the distal direction into the container holder 400. If a locking element of the aforementioned type is present, the user overcomes this increased force or solves the aforementioned locking connection in a different way.
  • the proximal support flange 112 bears against a stop edge 412 of the container holder, which is formed by an annular recess in a retaining flange 411 of the container holder.
  • the user removes the two second (proximal) seals 160 and pushes the actuator 430 from the proximal end into the actuation openings 113 of the two containers 100 to advance the two pistons 120 of the containers 100 and so on the respective products received in the containers 100 through the respective outlet opening 111 eject.
  • the respective product passes through the corresponding fluid channel 422 to the corresponding Ent.öffhung 415.
  • the situation at the end of this discharge operation is shown in FIG. 9.
  • a connection structure for an accessory 500 is formed, which is designed here as a static mixer.
  • the accessory receives the ejected products from the extraction opening 415, mixes them together, and dispenses the mixture at its own distal end.
  • the connection of the accessory 500 with the container holder 400 takes place here via a bayonet-type connection.
  • Such an accessory as well as its connection to a discharge device is described in detail in particular in document US 2001/0004082, to which reference is explicitly made here with regard to the connection of the accessory to the discharge device.
  • the connection between the accessory and the container holder may be formed in another known manner, e.g. as a plug connection via luer cone.
  • the container contains a second product, this may be present instead of in a second base body, which is arranged parallel to the first base body, in a differently arranged second reservoir, for example in a second receiving area arranged concentrically to a first receiving area.
  • a second base body which is arranged parallel to the first base body, in a differently arranged second reservoir, for example in a second receiving area arranged concentrically to a first receiving area.
  • containers for three or more components are possible.
  • the coating does not need to be aluminum but may also be e.g. be formed of other metals, of metal compounds or by a plastic barrier layer. It can also be multilayered. It may additionally or alternatively be applied to the inside of the base body.
  • the body does not need to be integral, and the wall on which the coating is applied does not necessarily have to be a wall which immediately defines the product. So there are also more complex embodiments of the container as the embodiments shown here conceivable.
  • the container may also be closed at the outlet opening in addition to the seal 150 by a further closure arranged inside the seal, for example by a stopper or a septum.
  • a further closure arranged inside the seal, for example by a stopper or a septum.
  • Rejuvenation 400 container holder distal support flange 410 receiving area, 120 'piston 411 retaining flange

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Coating Apparatus (AREA)
  • Closures For Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

Contenant (100) de type seringue, qui comporte un corps de base creux (110) pourvu d'un orifice de sortie (111) distal et d'un orifice d'actionnement (113) proximal permettant d'introduire un élément d'actionnement (200). Un piston (120), qui est placé coulissant à l'intérieur du corps de base, est destiné à évacuer du contenant un produit coulant (130). Pour réduire la perméabilité du contenant, le corps de base comporte une couche barrière (140) réduisant la diffusion. L'orifice de sortie est scellé par un premier opercule (150) pouvant être ôté ou percé et l'orifice d'actionnement est fermé par un second opercule (160).
EP10757559A 2009-09-22 2010-09-17 Contenant scellé pourvu d'un piston coulissant Withdrawn EP2480271A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH14622009 2009-09-22
PCT/CH2010/000227 WO2011035449A2 (fr) 2009-09-22 2010-09-17 Contenant scellé pourvu d'un piston coulissant

Publications (1)

Publication Number Publication Date
EP2480271A2 true EP2480271A2 (fr) 2012-08-01

Family

ID=41586746

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10757559A Withdrawn EP2480271A2 (fr) 2009-09-22 2010-09-17 Contenant scellé pourvu d'un piston coulissant

Country Status (4)

Country Link
US (1) US20120175384A1 (fr)
EP (1) EP2480271A2 (fr)
CN (1) CN102665803A (fr)
WO (1) WO2011035449A2 (fr)

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US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
US11624115B2 (en) 2010-05-12 2023-04-11 Sio2 Medical Products, Inc. Syringe with PECVD lubrication
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
DE102011106735A1 (de) * 2011-05-03 2012-11-08 Fischbach Kg Kunststoff-Technik Auspressbehälter
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US20120175384A1 (en) 2012-07-12
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WO2011035449A2 (fr) 2011-03-31
WO2011035449A8 (fr) 2012-04-12

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