EP2187874A2 - Zusammensetzungen aus trimetazidin mit verzögerter freisetzung und verfahren zu ihrer herstellung - Google Patents

Zusammensetzungen aus trimetazidin mit verzögerter freisetzung und verfahren zu ihrer herstellung

Info

Publication number
EP2187874A2
EP2187874A2 EP08852448A EP08852448A EP2187874A2 EP 2187874 A2 EP2187874 A2 EP 2187874A2 EP 08852448 A EP08852448 A EP 08852448A EP 08852448 A EP08852448 A EP 08852448A EP 2187874 A2 EP2187874 A2 EP 2187874A2
Authority
EP
European Patent Office
Prior art keywords
composition
weight
trimetazidine
pharmaceutically acceptable
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08852448A
Other languages
English (en)
French (fr)
Inventor
Deepak Anant Hegde
Sandhya Rajendra Shenoy
Harish Tulsidutt Bhatt
Ashok Omray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pvt Ltd
Original Assignee
USV Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pvt Ltd filed Critical USV Pvt Ltd
Publication of EP2187874A2 publication Critical patent/EP2187874A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
EP08852448A 2007-08-08 2008-08-07 Zusammensetzungen aus trimetazidin mit verzögerter freisetzung und verfahren zu ihrer herstellung Withdrawn EP2187874A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1533MU2007 2007-08-08
PCT/IN2008/000493 WO2009066315A2 (en) 2007-08-08 2008-08-07 Sustained release compositions of trimetazidine and process for preparation thereof

Publications (1)

Publication Number Publication Date
EP2187874A2 true EP2187874A2 (de) 2010-05-26

Family

ID=40667940

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08852448A Withdrawn EP2187874A2 (de) 2007-08-08 2008-08-07 Zusammensetzungen aus trimetazidin mit verzögerter freisetzung und verfahren zu ihrer herstellung

Country Status (3)

Country Link
EP (1) EP2187874A2 (de)
BR (1) BRPI0815602A2 (de)
WO (1) WO2009066315A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012515757A (ja) * 2009-01-20 2012-07-12 マイクロ ラブス リミテッド トリメタジジンの放出調節固形薬剤組成物及びその製造方法
TR201001902A2 (tr) * 2010-03-12 2011-04-21 Ali̇ Rai̇f İlaç Sanayi̇ Ve Ti̇caret A.Ş. Uzatılmış salınımlı trimetazidin tablet
US20110274751A1 (en) * 2010-05-04 2011-11-10 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Trimetazidine formulation with different release profiles
EP2386302A1 (de) * 2010-05-11 2011-11-16 Ranbaxy Laboratories Limited Pharmazeutische Dosierungsform von Trimetazidin mit verzögerter Freisetzung und Herstellungsverfahren dafür
WO2013180676A1 (en) * 2012-05-28 2013-12-05 Mahmut Bilgic A new sustained release formulation
CN105434380A (zh) * 2015-12-11 2016-03-30 南京正科医药股份有限公司 一种盐酸曲美他嗪片
US11123345B2 (en) 2016-11-21 2021-09-21 Saghmos Therapeutics, Inc. Prevention and/or treatment of contrast-induced acute kidney injury
CN111093662B (zh) 2017-06-20 2023-10-03 安布里亚制药公司 用于提高心脏代谢效率的组合物和方法
CN110623934B (zh) * 2019-09-26 2022-05-13 杭州百诚医药科技股份有限公司 一种盐酸曲美他嗪缓释片及其制备方法
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
CN111888476A (zh) * 2020-08-17 2020-11-06 深圳市道科思医药有限公司 盐酸曲美他嗪的改良释放药物组合物
CN112315942B (zh) * 2020-11-04 2022-08-09 南京康川济医药科技有限公司 一种盐酸曲美他嗪缓释制剂及其制备方法
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE442852T1 (de) * 2000-10-05 2009-10-15 Usv Ltd Trimetazidine enthaltendes arzneimittel mit verzögerter wirkstoffabgabe und verfahren zur herstellung
FR2818549B1 (fr) * 2000-12-26 2003-02-07 Servier Lab Composition pharmaceutique solide thermoformable pour la liberation controlee de trimetazidine
FR2885807B1 (fr) * 2005-05-18 2008-05-16 Mg Pharma Composition pharmaceutique solide a liberation prolongee de 1-(2,3,4-trimethoxybenzyl) piperazine, et procede de preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AVINASH D.: "Formulation and Evaluation of Sustained release Tablets of Trimetazidine Dihydrochloride using various Polymers", AAPS ANNUAL MEETING AND EXPOSITION, 31 October 2006 (2006-10-31), pages 1 - 2, XP003032101

Also Published As

Publication number Publication date
WO2009066315A3 (en) 2009-09-24
BRPI0815602A2 (pt) 2015-03-03
WO2009066315A2 (en) 2009-05-28

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