Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
  • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
  • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
  • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
  • A61K9/1605—Excipients; Inactive ingredients
  • A61K9/1629—Organic macromolecular compounds
  • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
  • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
  • A61K9/1605—Excipients; Inactive ingredients
  • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals

Definitions

• the present invention relates to a process for preparing a system for delivering active principles, in particular active principles of vegetable origin.
• the invention also relates to a dietary supplement, a preparation for preparing an infusion, a decoction or a maceration and also a pharmaceutical product comprising such an active agent delivery system.
• Plant extracts can be obtained by different extraction methods.
• the extracts obtained can be in a powder form whose particle size can vary from 5 to 500 microns.
• the extracts can be concentrated between 2 to 50 times compared to the initial weight of the plant used.
• Some food supplements come in the form of capsules, or tablets, containing fragments of crushed plants. These dietary supplements are not concentrated in active principles and each unit of complement does not allow to deliver a sufficient dose of active ingredients to enable them a significant activity. It is then necessary to repeat the supplement several times during the same day or to take several units per intake.
• preparations in the form of teas or infusion comprising supports consisting of plant fragments, such as tea leaves, on which is adsorbed a powder, for example a powder of dry plant extract .
• Such preparations constitute active ingredient delivery systems that can be used for the preparation of infusions, decoctions or macerations, and be consumed by the user during a relaxation time.
• the processes for preparing these teas generally consist in mixing in the same tank the supports composed of plant fragments with the powder in solution or mixing the supports with the powder and an aqueous solution, or water, when of the same step. These methods are not entirely satisfactory.
• the objective of the present invention is to propose a process for manufacturing an active principle delivery system that can be used for the preparation of infusions, decoctions or macerations, which makes it possible to limit the loss of active ingredients during of the preparation and which allows to control the amount of powder adsorbed on the support.
• the invention relates to a method for manufacturing an active agent delivery system comprising a step of forming a complex consisting of a support consisting of whole plants, or parts of plants, dried, and of a powder comprising at least one active principle adsorbed on the entire surface of said support, said method being characterized in that said step of forming said complex comprises the following steps: a step of distributing a predetermined quantity of said support in a mixer,
• the method thus consists in permanently adsorbing the powder comprising the active ingredient (s) on the support.
• the complex thus obtained by the process according to the invention is perfectly stable.
• the aqueous solution, or water is used to achieve adhesion. Indeed, the support and the powder possessing a hygroscopic character, the aqueous solution or the water sprayed on the support allows to somehow attract the powder comprising the active ingredients.
• delivery systems according to the invention are intended for human consumption and contain active ingredients having a functional activity in the human body. It is thus necessary that the concentrations of active principles in such a delivery system are known and stable over time.
• the physical difference such as the difference in size, between the powders and the dried plant fragments intended for the preparation of teas, herbal teas or any other beverage, does not make it possible to obtain a stable mixture over time.
• the size of these dried plant fragments varies between 1 and 10 mm while the size of the powder particles is of the order of one hundred micrometers. This only difference in size between these two components results in a phenomenon called phase shift.
• the powder is added only when the surface of the support, and not the walls of the tank, is moistened.
• the dusting step is stopped when said powder is no longer adsorbed on said support. The spraying and dusting steps are thus repeated if necessary, which on the one hand makes it possible to adsorb the totality of the quantity of powder provided and, on the other hand, to create several layers of powders.
• the active ingredient delivery system obtained is structurally very different from known delivery systems such as capsules or tablets.
• the carrier of the powder is of plant origin and therefore does not require the addition of chemical compounds such as excipients commonly used in the manufacture of capsules or tablets. It is not a mixture of components but a complex because the powder is adsorbed on the plant parts constituting its support.
• the predetermined quantity of aqueous solution or water is between 2 and 25% by weight relative to the total weight of all the components used to form said complex.
• the amount of aqueous solution or water is an important feature of the process.
• the amount of aqueous solution or water used varies slightly depending on the type of support and / or powder used.
• the method further comprises a step of mixing said complex and a predetermined quantity of dried plant fragments intended to be used in infusion, decoction or maceration, making it possible to obtain a homogeneous mixture.
• the mixture obtained can be used for the preparation of teas or herbal teas, in the same way as preparations for conventional teas and herbal teas. But unlike these conventional preparations, the mixtures according to the invention are enriched in active principles.
• said support is composed of whole plants, or parts of plants, dried, selected from the group comprising dried cherry tails, dried raspberry seeds, dried bitter orange peel, dried and crushed limes peel dried and ground ginger, dried poppy seeds, dried flaxseed, dried rosehip seeds, dried angelica fruit, tea leaves, mint leaves, or mixtures thereof.
• the dried plants or parts of plants used as a support on which the powder is adsorbed are of a size relatively close to the size of the dried plant fragments intended for infusion, decoction or maceration.
• said predetermined quantity of dried plant fragments intended to be used in infusion, decoction or maceration is between 5 and 95% by weight relative to the total weight of said delivery system.
• said solution comprising water comprises, in addition, between 0.5 and 30% by weight of a gelling compound.
• the gelling compound makes it possible to reinforce the cohesion between the powder and the support.
• said gelling compound is a food additive chosen from alginates or gelatin, carrageenans, or agar-agar.
• said method further comprises a step of adding between 1 and 3% by weight of colloidal silica with respect to the total weight of all the components used to form said complex, prior to said step of drying and a sieving step subsequent to said drying step.
• Colloidal silica facilitates the handling of the delivery system and prevents it from clumping together. It is removed by the sieving step.
• said predetermined quantity of powder is between 5 and 70% of the weight of said complex formed and said predetermined amount of support is between 30 and 95% of the weight of said complex formed.
• the total weight of said complex formed corresponds to the sum of the weights of the support and the powder, the aqueous solution, or water, and the silica being removed during the drying and sieving steps, respectively.
• said powder comprising at least one active ingredient is composed of at least one dry extract of a plant, in particular a plant that can be used in the fields of herbal medicine, beauty or welfare.
• said powder comprising at least one active principle is composed of a dry extract of a plant chosen from the group consisting of a dry extract of grape seeds, a dry extract of melissa, a dry extract of hops, a dry extract of green coffee, a dry extract of guarana, a dry extract of dandelion, a dry extract of valerian, a dry extract of orange blossom, a dry extract of black radish, a dry extract of red vine, a dry extract of ginseng, or their mixture.
• said dry plant extract is obtained by a nebulization method.
• the dry extracts of plants used in the process according to the invention are preferably obtained by extraction processes involving the following steps: harvesting whole plants, percolation in water or a mixture of alcohol and water, insulation of the fluid extract by pressing, obtaining the dry extracts by nebulization, mixing the dry extracts with maltodextrin and grinding.
• said powder comprises between 4 and 65% of maltodextrin.
• Maltodextrin increases the stability of the complex formed by the powder adsorbed on the support.
• said powder is composed of at least one solids extract of alga, such as ⁇ -carotene, polysaccharides, amino acids, peptides, proteins.
• said powder is composed of at least one dry extract of animal origin, such as freeze-dried royal jelly or collagen.
• said powder comprising at least one active ingredient is composed of at least one dry extract of a plant appearing in the list of the French, European or international pharmacopoeia.
• the invention also relates to a delivery system for active principles, for example a dietary supplement, comprising a complex consisting of a carrier composed of whole plants, or parts of plants, dried, and a powder comprising at least one principle active agent adsorbed on the entire surface of said support, said delivery system being obtained by a method as described above.
• a delivery system for active principles for example a dietary supplement, comprising a complex consisting of a carrier composed of whole plants, or parts of plants, dried, and a powder comprising at least one principle active agent adsorbed on the entire surface of said support, said delivery system being obtained by a method as described above.
• said powder of said delivery system of active principles comprises between 4 and 65% of maltodextrin.
• Example 1 Process for the Production of a System for Delivery of Active Ingredients Extracted from Hops (Humulus lupulus) and Valerian ⁇ Valeriana officinalis)
• the active ingredients are in the form of powders of dried extracts of hops and valerians, respectively.
• the powders of dry extracts are mixed together.
• the dried and ground bitter orange peel is used as a support for the dry extract powder.
• the entire amount of the carrier consisting of milled and dried bitter orange peel fragments, is placed in a mixer, for example of the worm, blade or turbine type.
• the aqueous solution comprising 2% sodium alginate is sprayed into the mixer so as to imbibe each of the bark fragments with water.
• the surface of the bark fragments is thus covered with water.
• the spray is stopped when the spray solution is no longer absorbed by the bark fragments and is free in the mixer. In this spraying step, only a portion of the total amount of aqueous solution may be sprayed. A simple visual check allows the skilled person to determine when the spray solution is no longer absorbed.
• the powder of dry extracts is then added to the mixer by dusting.
• the powder which is hygroscopic, will be attracted by the water present on the surface of the bark fragments and thus adsorb on the support.
• the dusting of the powder is stopped when the powder is no longer adsorbed on the support and is found free in the mixer.
• a new step of spraying the aqueous solution is then carried out so as to re-soak the support, followed by a new dusting step of the powder of dry extracts. These two steps are repeated until the total amount of dry extract powder is adsorbed onto the support.
• a complex consisting of the powder of dry extracts adsorbed on the support is thus formed, in which each bark fragment of the support is coated with powder.
• the amount of aqueous solution sprayed in total, and during each spraying step, is an important feature of the process. Indeed, if too much of the solution is sprayed into the mixer, part of this solution will not be absorbed by the support and will be free, mainly in the form of drops on the walls of the mixer. During the dusting step, a portion of the dry dust powder dusted will be attracted by these drops and will not be adsorbed on the support. This phenomenon could lead to a consequent loss of dry extracts.
• the total amount of aqueous spray solution is between 2 and 25% by weight based on the total weight of all components used to form the complex. The total amount of aqueous solution in this example is 11.2%.
• Colloidal silica is then added to the complex formed at 2.8% by weight relative to the total weight of all the components. Colloidal silica makes it easier to handle the complex.
• the complex is then dried, for example in an oven, at a temperature between 40 and 50 0 C for 24 to 48 hours.
• the complex is subjected to a sieving step on a sieve of mesh of 1 to 2 mm.
• Sieving eliminates colloidal silica.
• This delivery system is composed for 55% of support and for 45% of dry extracts.
• the active ingredients are in the form of powders of dry extracts of Guarana and ginger, respectively.
• the powders of dry extracts are mixed together.
• Dried and ground ginger root is used as a carrier for the dry extract powder.
• the steps of the process for producing the active principle delivery system extracted from Guarana and ginger are identical to those described in Example 1.
• the delivery system obtained is composed of 50% of support and 50% of solids. (Table 6).
• Example 3 Process for the manufacture of a system for delivering active principles extracted from Guarana (Paullinia Cupana) and ginger (Zingiber officinale).
• the active ingredients are in the form of powders of dry extracts of Guarana and ginger, respectively.
• the powders of dry extracts are mixed together.
• Dried green tea leaves are used as a support for the dry extract powder.
• the steps of the process for producing the active principle delivery system extracted from Guarana and ginger are identical to those described in previous examples.
• the delivery system obtained comprises 50% of support and 50% of dry extracts (Table 6).
• Example 4 Process for the Production of a Delivery System for Active Ingredients Extracted from Black Radish (Raphanus sativus)
• the active ingredients are in the form of a dry extract powder of black radish. Dried cherry tails are used as a carrier for the dry extract powder.
• the steps of the process for producing the active principle delivery system extracted from black radish are identical to those described in the preceding examples.
• the delivery system obtained comprises 45% of support and 55% of dry extracts (Table 6).
• EXAMPLE 5 System for delivering active principles extracted from hops (Humulus lupulus) and valerian (Valeriana officinalis) containing plant fragments intended for infusion.
• hops Human lupulus
• valerian valerian
• the mixing step is carried out after the step of drying the complex.
• the mixture obtained is homogeneous and comprises 25% of the complex and 75% of tea leaves.
• EXAMPLE 6 Preparation for infusion in the form of a dosed sachet comprising a system for delivery of active principles extracted from hops (Humulus lupulus) and valerian ⁇ Valeriana officinalis)
• the delivery system according to Example 5 can be used for the preparation of dosed sachets, such as the dosed sachets known and used for the preparation of beverages such as teas.
• the sachets contain, on average, 2 g of product.
• the detailed composition of one of these dosed sachets is given in Table 5.
• Table 6 Final compositions of Examples 1 to 4, obtained after the steps of drying and removing the silica by sieving.
• the steps of the manufacturing processes of the active substance delivery systems extracted from the plants mentioned in Table 7 are identical to those described in Example 1.
• the dry extract powders used were obtained by nebulization methods. To do this, the whole plants were harvested, weighed and then subjected to a percolation step in water, or a mixture of water and alcohol. The fluid extracts were isolated by pressing the plants and then microfiltered. The water or the mixture of water and alcohol was evaporated by nebulization. The dry extracts thus prepared were mixed with maltodextrin in the proportions indicated in Table 7 and the mixtures were ground. The powders obtained were used in processes for preparing delivery systems as described in Example 1.

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• 2007
  • 2007-09-03 FR FR0706153A patent/FR2920276B1/fr active Active
• 2008
  • 2008-09-01 WO PCT/EP2008/061497 patent/WO2009030666A1/fr active Application Filing
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