EP2187870A1 - Method of producing a system for delivering active ingredients of plant origin - Google Patents

Method of producing a system for delivering active ingredients of plant origin

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Publication number
EP2187870A1
EP2187870A1 EP08803478A EP08803478A EP2187870A1 EP 2187870 A1 EP2187870 A1 EP 2187870A1 EP 08803478 A EP08803478 A EP 08803478A EP 08803478 A EP08803478 A EP 08803478A EP 2187870 A1 EP2187870 A1 EP 2187870A1
Authority
EP
European Patent Office
Prior art keywords
powder
delivery system
dried
support
dry extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP08803478A
Other languages
German (de)
French (fr)
Inventor
Christophe Arneodo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viviane Lab
Original Assignee
Viviane Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viviane Lab filed Critical Viviane Lab
Publication of EP2187870A1 publication Critical patent/EP2187870A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals

Definitions

  • the present invention relates to a process for preparing a system for delivering active principles, in particular active principles of vegetable origin.
  • the invention also relates to a dietary supplement, a preparation for preparing an infusion, a decoction or a maceration and also a pharmaceutical product comprising such an active agent delivery system.
  • Plant extracts can be obtained by different extraction methods.
  • the extracts obtained can be in a powder form whose particle size can vary from 5 to 500 microns.
  • the extracts can be concentrated between 2 to 50 times compared to the initial weight of the plant used.
  • Some food supplements come in the form of capsules, or tablets, containing fragments of crushed plants. These dietary supplements are not concentrated in active principles and each unit of complement does not allow to deliver a sufficient dose of active ingredients to enable them a significant activity. It is then necessary to repeat the supplement several times during the same day or to take several units per intake.
  • preparations in the form of teas or infusion comprising supports consisting of plant fragments, such as tea leaves, on which is adsorbed a powder, for example a powder of dry plant extract .
  • Such preparations constitute active ingredient delivery systems that can be used for the preparation of infusions, decoctions or macerations, and be consumed by the user during a relaxation time.
  • the processes for preparing these teas generally consist in mixing in the same tank the supports composed of plant fragments with the powder in solution or mixing the supports with the powder and an aqueous solution, or water, when of the same step. These methods are not entirely satisfactory.
  • the objective of the present invention is to propose a process for manufacturing an active principle delivery system that can be used for the preparation of infusions, decoctions or macerations, which makes it possible to limit the loss of active ingredients during of the preparation and which allows to control the amount of powder adsorbed on the support.
  • the invention relates to a method for manufacturing an active agent delivery system comprising a step of forming a complex consisting of a support consisting of whole plants, or parts of plants, dried, and of a powder comprising at least one active principle adsorbed on the entire surface of said support, said method being characterized in that said step of forming said complex comprises the following steps: a step of distributing a predetermined quantity of said support in a mixer,
  • the method thus consists in permanently adsorbing the powder comprising the active ingredient (s) on the support.
  • the complex thus obtained by the process according to the invention is perfectly stable.
  • the aqueous solution, or water is used to achieve adhesion. Indeed, the support and the powder possessing a hygroscopic character, the aqueous solution or the water sprayed on the support allows to somehow attract the powder comprising the active ingredients.
  • delivery systems according to the invention are intended for human consumption and contain active ingredients having a functional activity in the human body. It is thus necessary that the concentrations of active principles in such a delivery system are known and stable over time.
  • the physical difference such as the difference in size, between the powders and the dried plant fragments intended for the preparation of teas, herbal teas or any other beverage, does not make it possible to obtain a stable mixture over time.
  • the size of these dried plant fragments varies between 1 and 10 mm while the size of the powder particles is of the order of one hundred micrometers. This only difference in size between these two components results in a phenomenon called phase shift.
  • the powder is added only when the surface of the support, and not the walls of the tank, is moistened.
  • the dusting step is stopped when said powder is no longer adsorbed on said support. The spraying and dusting steps are thus repeated if necessary, which on the one hand makes it possible to adsorb the totality of the quantity of powder provided and, on the other hand, to create several layers of powders.
  • the active ingredient delivery system obtained is structurally very different from known delivery systems such as capsules or tablets.
  • the carrier of the powder is of plant origin and therefore does not require the addition of chemical compounds such as excipients commonly used in the manufacture of capsules or tablets. It is not a mixture of components but a complex because the powder is adsorbed on the plant parts constituting its support.
  • the predetermined quantity of aqueous solution or water is between 2 and 25% by weight relative to the total weight of all the components used to form said complex.
  • the amount of aqueous solution or water is an important feature of the process.
  • the amount of aqueous solution or water used varies slightly depending on the type of support and / or powder used.
  • the method further comprises a step of mixing said complex and a predetermined quantity of dried plant fragments intended to be used in infusion, decoction or maceration, making it possible to obtain a homogeneous mixture.
  • the mixture obtained can be used for the preparation of teas or herbal teas, in the same way as preparations for conventional teas and herbal teas. But unlike these conventional preparations, the mixtures according to the invention are enriched in active principles.
  • said support is composed of whole plants, or parts of plants, dried, selected from the group comprising dried cherry tails, dried raspberry seeds, dried bitter orange peel, dried and crushed limes peel dried and ground ginger, dried poppy seeds, dried flaxseed, dried rosehip seeds, dried angelica fruit, tea leaves, mint leaves, or mixtures thereof.
  • the dried plants or parts of plants used as a support on which the powder is adsorbed are of a size relatively close to the size of the dried plant fragments intended for infusion, decoction or maceration.
  • said predetermined quantity of dried plant fragments intended to be used in infusion, decoction or maceration is between 5 and 95% by weight relative to the total weight of said delivery system.
  • said solution comprising water comprises, in addition, between 0.5 and 30% by weight of a gelling compound.
  • the gelling compound makes it possible to reinforce the cohesion between the powder and the support.
  • said gelling compound is a food additive chosen from alginates or gelatin, carrageenans, or agar-agar.
  • said method further comprises a step of adding between 1 and 3% by weight of colloidal silica with respect to the total weight of all the components used to form said complex, prior to said step of drying and a sieving step subsequent to said drying step.
  • Colloidal silica facilitates the handling of the delivery system and prevents it from clumping together. It is removed by the sieving step.
  • said predetermined quantity of powder is between 5 and 70% of the weight of said complex formed and said predetermined amount of support is between 30 and 95% of the weight of said complex formed.
  • the total weight of said complex formed corresponds to the sum of the weights of the support and the powder, the aqueous solution, or water, and the silica being removed during the drying and sieving steps, respectively.
  • said powder comprising at least one active ingredient is composed of at least one dry extract of a plant, in particular a plant that can be used in the fields of herbal medicine, beauty or welfare.
  • said powder comprising at least one active principle is composed of a dry extract of a plant chosen from the group consisting of a dry extract of grape seeds, a dry extract of melissa, a dry extract of hops, a dry extract of green coffee, a dry extract of guarana, a dry extract of dandelion, a dry extract of valerian, a dry extract of orange blossom, a dry extract of black radish, a dry extract of red vine, a dry extract of ginseng, or their mixture.
  • said dry plant extract is obtained by a nebulization method.
  • the dry extracts of plants used in the process according to the invention are preferably obtained by extraction processes involving the following steps: harvesting whole plants, percolation in water or a mixture of alcohol and water, insulation of the fluid extract by pressing, obtaining the dry extracts by nebulization, mixing the dry extracts with maltodextrin and grinding.
  • said powder comprises between 4 and 65% of maltodextrin.
  • Maltodextrin increases the stability of the complex formed by the powder adsorbed on the support.
  • said powder is composed of at least one solids extract of alga, such as ⁇ -carotene, polysaccharides, amino acids, peptides, proteins.
  • said powder is composed of at least one dry extract of animal origin, such as freeze-dried royal jelly or collagen.
  • said powder comprising at least one active ingredient is composed of at least one dry extract of a plant appearing in the list of the French, European or international pharmacopoeia.
  • the invention also relates to a delivery system for active principles, for example a dietary supplement, comprising a complex consisting of a carrier composed of whole plants, or parts of plants, dried, and a powder comprising at least one principle active agent adsorbed on the entire surface of said support, said delivery system being obtained by a method as described above.
  • a delivery system for active principles for example a dietary supplement, comprising a complex consisting of a carrier composed of whole plants, or parts of plants, dried, and a powder comprising at least one principle active agent adsorbed on the entire surface of said support, said delivery system being obtained by a method as described above.
  • said powder of said delivery system of active principles comprises between 4 and 65% of maltodextrin.
  • Example 1 Process for the Production of a System for Delivery of Active Ingredients Extracted from Hops (Humulus lupulus) and Valerian ⁇ Valeriana officinalis)
  • the active ingredients are in the form of powders of dried extracts of hops and valerians, respectively.
  • the powders of dry extracts are mixed together.
  • the dried and ground bitter orange peel is used as a support for the dry extract powder.
  • the entire amount of the carrier consisting of milled and dried bitter orange peel fragments, is placed in a mixer, for example of the worm, blade or turbine type.
  • the aqueous solution comprising 2% sodium alginate is sprayed into the mixer so as to imbibe each of the bark fragments with water.
  • the surface of the bark fragments is thus covered with water.
  • the spray is stopped when the spray solution is no longer absorbed by the bark fragments and is free in the mixer. In this spraying step, only a portion of the total amount of aqueous solution may be sprayed. A simple visual check allows the skilled person to determine when the spray solution is no longer absorbed.
  • the powder of dry extracts is then added to the mixer by dusting.
  • the powder which is hygroscopic, will be attracted by the water present on the surface of the bark fragments and thus adsorb on the support.
  • the dusting of the powder is stopped when the powder is no longer adsorbed on the support and is found free in the mixer.
  • a new step of spraying the aqueous solution is then carried out so as to re-soak the support, followed by a new dusting step of the powder of dry extracts. These two steps are repeated until the total amount of dry extract powder is adsorbed onto the support.
  • a complex consisting of the powder of dry extracts adsorbed on the support is thus formed, in which each bark fragment of the support is coated with powder.
  • the amount of aqueous solution sprayed in total, and during each spraying step, is an important feature of the process. Indeed, if too much of the solution is sprayed into the mixer, part of this solution will not be absorbed by the support and will be free, mainly in the form of drops on the walls of the mixer. During the dusting step, a portion of the dry dust powder dusted will be attracted by these drops and will not be adsorbed on the support. This phenomenon could lead to a consequent loss of dry extracts.
  • the total amount of aqueous spray solution is between 2 and 25% by weight based on the total weight of all components used to form the complex. The total amount of aqueous solution in this example is 11.2%.
  • Colloidal silica is then added to the complex formed at 2.8% by weight relative to the total weight of all the components. Colloidal silica makes it easier to handle the complex.
  • the complex is then dried, for example in an oven, at a temperature between 40 and 50 0 C for 24 to 48 hours.
  • the complex is subjected to a sieving step on a sieve of mesh of 1 to 2 mm.
  • Sieving eliminates colloidal silica.
  • This delivery system is composed for 55% of support and for 45% of dry extracts.
  • the active ingredients are in the form of powders of dry extracts of Guarana and ginger, respectively.
  • the powders of dry extracts are mixed together.
  • Dried and ground ginger root is used as a carrier for the dry extract powder.
  • the steps of the process for producing the active principle delivery system extracted from Guarana and ginger are identical to those described in Example 1.
  • the delivery system obtained is composed of 50% of support and 50% of solids. (Table 6).
  • Example 3 Process for the manufacture of a system for delivering active principles extracted from Guarana (Paullinia Cupana) and ginger (Zingiber officinale).
  • the active ingredients are in the form of powders of dry extracts of Guarana and ginger, respectively.
  • the powders of dry extracts are mixed together.
  • Dried green tea leaves are used as a support for the dry extract powder.
  • the steps of the process for producing the active principle delivery system extracted from Guarana and ginger are identical to those described in previous examples.
  • the delivery system obtained comprises 50% of support and 50% of dry extracts (Table 6).
  • Example 4 Process for the Production of a Delivery System for Active Ingredients Extracted from Black Radish (Raphanus sativus)
  • the active ingredients are in the form of a dry extract powder of black radish. Dried cherry tails are used as a carrier for the dry extract powder.
  • the steps of the process for producing the active principle delivery system extracted from black radish are identical to those described in the preceding examples.
  • the delivery system obtained comprises 45% of support and 55% of dry extracts (Table 6).
  • EXAMPLE 5 System for delivering active principles extracted from hops (Humulus lupulus) and valerian (Valeriana officinalis) containing plant fragments intended for infusion.
  • hops Human lupulus
  • valerian valerian
  • the mixing step is carried out after the step of drying the complex.
  • the mixture obtained is homogeneous and comprises 25% of the complex and 75% of tea leaves.
  • EXAMPLE 6 Preparation for infusion in the form of a dosed sachet comprising a system for delivery of active principles extracted from hops (Humulus lupulus) and valerian ⁇ Valeriana officinalis)
  • the delivery system according to Example 5 can be used for the preparation of dosed sachets, such as the dosed sachets known and used for the preparation of beverages such as teas.
  • the sachets contain, on average, 2 g of product.
  • the detailed composition of one of these dosed sachets is given in Table 5.
  • Table 6 Final compositions of Examples 1 to 4, obtained after the steps of drying and removing the silica by sieving.
  • the steps of the manufacturing processes of the active substance delivery systems extracted from the plants mentioned in Table 7 are identical to those described in Example 1.
  • the dry extract powders used were obtained by nebulization methods. To do this, the whole plants were harvested, weighed and then subjected to a percolation step in water, or a mixture of water and alcohol. The fluid extracts were isolated by pressing the plants and then microfiltered. The water or the mixture of water and alcohol was evaporated by nebulization. The dry extracts thus prepared were mixed with maltodextrin in the proportions indicated in Table 7 and the mixtures were ground. The powders obtained were used in processes for preparing delivery systems as described in Example 1.

Abstract

The present invention relates to a method of producing a system for delivering active ingredients, comprising at least one complex constituted of a carrier composed of dried whole plants, or dried parts of plants, and of a powder comprising at least one active ingredient adsorbed onto the entire surface of said carrier. The method according to the invention is characterized in that it comprises a step of forming said complex which comprises the following steps: - a step of dispensing a predetermined amount of said carrier into a mixer, - a step of spraying all or part of a predetermined amount of an aqueous solution or of water onto said carrier so as to moisten each plant, or part of plant, of said carrier, in such a way that all of said aqueous solution or of the water then sprayed is absorbed by said carrier, wherein said spraying step is stopped when said aqueous solution or the water is no longer absorbed by said carrier; - a step of dusting all or part of a predetermined amount of said powder in such a way that all of said powder then dusted is adsorbed onto said carrier, wherein said dusting step is stopped when said powder is no longer adsorbed onto said carrier; - if not all of the predetermined amount of said powder has been dusted, said method is recommenced starting from the step of spraying said solution comprising water onto said carrier, - a step of drying said complex formed. The resulting system for delivering active ingredients may, by virtue of the carrier thereof constituted of dried whole plants, or dried parts of plants, and according to the type of carrier employed, be used for the preparation of infusions, decoctions or macerations, and be consumed by the user during a moment of relaxation.

Description

PROCEDE DE FABRICATION D' UN SYSTEME DE DELIVRANCE DE PRINCIPES ACTIFS DORIGINE VEGETALE PROCESS FOR MANUFACTURING A DELIVERY SYSTEM FOR ACTIVE INGREDIENTS OF PLANT ORIGIN
La présente invention concerne un procédé de préparation d'un système de délivrance de principes actifs, en particulier de principes actifs d'origine végétale.The present invention relates to a process for preparing a system for delivering active principles, in particular active principles of vegetable origin.
L'invention concerne également un complément alimentaire, une préparation destinée à préparer une infusion, une décoction ou encore une macération et encore un produit pharmaceutique comprenant un tel système de délivrance de principes actifs.The invention also relates to a dietary supplement, a preparation for preparing an infusion, a decoction or a maceration and also a pharmaceutical product comprising such an active agent delivery system.
De nombreuses plantes sont aujourd'hui connues et utilisées pour leurs vertus dans les domaines de la phytothérapie, de la beauté ou du bien être. Ces plantes contiennent en effet des substances, ou principes actifs, pouvant être extraits de la plante et dont l'activité bénéfique peut être utilisée par l'homme. II existe aujourd'hui de nombreux compléments alimentaires à base d'extraits de plantes. Les compléments alimentaires se présentent, par exemple, sous la forme de gélules, d'ampoules, de comprimés ou de boissons.Many plants are now known and used for their virtues in the fields of phytotherapy, beauty or well-being. These plants indeed contain substances or active ingredients that can be extracted from the plant and whose beneficial activity can be used by humans. There are now many food supplements based on plant extracts. Food supplements are, for example, in the form of capsules, ampoules, tablets or drinks.
Certaines plantes sont plus particulièrement utilisées dans le domaine de la phytothérapie. Ces plantes sont inscrites à la Pharmacopée, une liste répertoriant les plantes médicinales, et sont considérées alors comme des médicaments. Les extraits de plantes peuvent être obtenus par différentes méthodes d'extraction. Les extraits obtenus peuvent se présenter sous une forme pulvérulente dont la granulométrie peut varier de 5 à 500 microns. Selon la méthode d'extraction utilisée, les extraits peuvent être concentrés entre 2 à 50 fois par rapport au poids initial de la plante utilisée.Some plants are more particularly used in the field of herbal medicine. These plants are listed in the Pharmacopoeia, a list listing the medicinal plants, and are then considered as drugs. Plant extracts can be obtained by different extraction methods. The extracts obtained can be in a powder form whose particle size can vary from 5 to 500 microns. Depending on the extraction method used, the extracts can be concentrated between 2 to 50 times compared to the initial weight of the plant used.
Certains compléments alimentaires se présentent sous la forme de gélules, ou de comprimés, contenant des fragments de plantes broyées. Ces compléments alimentaires ne sont pas concentrés en principes actifs et chaque unité de complément ne permet pas de délivrer une dose suffisante de principes actifs pour leur permettre une activité significative. Il est alors nécessaire de répéter la prise du complément plusieurs fois au cours d'une même journée ou de prendre plusieurs unités par prise.Some food supplements come in the form of capsules, or tablets, containing fragments of crushed plants. These dietary supplements are not concentrated in active principles and each unit of complement does not allow to deliver a sufficient dose of active ingredients to enable them a significant activity. It is then necessary to repeat the supplement several times during the same day or to take several units per intake.
Il existe également des compléments alimentaires se présentant sous la forme de gélules, de comprimés, de sachets ou d'ampoules, contenant des extraits secs de plantes, et dans lesquels les principes actifs sont ainsi concentrés. L'inconvénient de ces compléments alimentaires est que la prise en elle-même de ces gélules, comprimés ou ampoules ne procure à l'utilisateur aucun plaisir gustatif et ne constitue pas un réel moment de détente.There are also food supplements in the form of capsules, tablets, sachets or ampoules, containing dry extracts of plants, and in which the active ingredients are thus concentrated. The disadvantage of these food supplements is that the taking in itself of these capsules, tablets or ampoules does not provide the user any pleasure and does not constitute a real moment of relaxation.
Il existe des préparations sous forme de sachets comprenant de la poudre d'extrait sec de plante soluble destinées à la préparation de boissons, par exemple chaudes, mais ces préparations correspondent à une simple dissolution de poudre qui apparaissent très éloignées de la préparation d'une infusion classique appréciée par un certain nombre de consommateurs.There are sachet preparations comprising soluble plant solids powder for the preparation of beverages, for example hot, but these preparations correspond to a simple dissolution of powder which appear far removed from the preparation of a powder. classic infusion appreciated by a number of consumers.
Il existe encore des préparations se présentant sous la forme de thés ou d'infusion et comprenant des supports composés de fragments de plantes, tels que des feuilles de thé, sur lesquels est adsorbée une poudre, par exemple un poudre d'extrait sec de plante. De telles préparations constituent des systèmes de délivrance de principes actifs qui peuvent être utilisées pour la préparation d'infusions, de décoctions ou de macérations, et être consommé par l'utilisateur au cours d'un moment de détente.There are still preparations in the form of teas or infusion and comprising supports consisting of plant fragments, such as tea leaves, on which is adsorbed a powder, for example a powder of dry plant extract . Such preparations constitute active ingredient delivery systems that can be used for the preparation of infusions, decoctions or macerations, and be consumed by the user during a relaxation time.
Les procédés de préparation de ces thés consistent généralement à mélanger dans une même cuve les supports composés de fragments de plantes avec la poudre en solution ou bien à mélanger les supports avec la poudre ainsi qu'une solution aqueuse, ou de l'eau, lors d'une même étape. Ces procédés ne sont pas entièrement satisfaisant.The processes for preparing these teas generally consist in mixing in the same tank the supports composed of plant fragments with the powder in solution or mixing the supports with the powder and an aqueous solution, or water, when of the same step. These methods are not entirely satisfactory.
En effet, dans la cuve la solution, ou l'eau, a tendance à se coller sur les parois de la cuve d'où elle attire la poudre. En conséquence, la totalité de la poudre ne sera pas adsorbée à la surface des supports. Il est alors difficile de contrôler la concentration en principes actifs dans les thés obtenus et la perte en principe actif peut être importante. Par ailleurs, il est impossible, par de tels procédés de préparation de réaliser plusieurs couches successives de poudre. D'autres procédés de fabrications de telles préparations utilisent des solutions d'enrobage, par exemple, à base d'amidon afin de maintenir une cohésion entre la poudre et le support. De tels enrobages peuvent présenter l'inconvénient de limiter la diffusion des principes actifs de la poudre lors de l'utilisation de la préparation.Indeed, in the tank solution, or water, tends to stick on the walls of the tank from which it attracts the powder. As a result, the totality of the powder will not be adsorbed on the surface of the supports. It is therefore difficult to control the concentration of active ingredients in the teas obtained and the loss of active ingredient may be important. Moreover, it is impossible, by such preparation methods, to produce several successive layers of powder. Other methods of making such preparations use coating solutions, for example, based on starch to maintain cohesion between the powder and the support. Such coatings may have the disadvantage of limiting the diffusion of the active ingredients of the powder during the use of the preparation.
L'objectif de la présente invention est de proposer un procédé de fabrication d'un système de délivrance de principes actifs qui puisse être utilisé pour la préparation d'infusions, de décoctions ou de macérations, qui permette de limiter la perte de principes actifs lors de la préparation et qui permette de contrôler la quantité de poudre adsorbée sur le support.The objective of the present invention is to propose a process for manufacturing an active principle delivery system that can be used for the preparation of infusions, decoctions or macerations, which makes it possible to limit the loss of active ingredients during of the preparation and which allows to control the amount of powder adsorbed on the support.
A cet effet, l'invention concerne un procédé de fabrication d'un système de délivrance de principes actifs comprenant une étape de formation d'un complexe constitué d'un support composé de plantes entières, ou parties de plantes, séchées, et d'une poudre comportant au moins un principe actif adsorbée sur l'ensemble de la surface dudit support, ledit procédé étant caractérisé en ce que ladite étape de formation dudit complexe comporte les étapes suivantes: - une étape de distribution d'une quantité prédéterminée dudit support dans un mélangeur,For this purpose, the invention relates to a method for manufacturing an active agent delivery system comprising a step of forming a complex consisting of a support consisting of whole plants, or parts of plants, dried, and of a powder comprising at least one active principle adsorbed on the entire surface of said support, said method being characterized in that said step of forming said complex comprises the following steps: a step of distributing a predetermined quantity of said support in a mixer,
- une étape de pulvérisation de tout ou partie d'une quantité prédéterminée d'une solution aqueuse ou d'eau sur ledit support de manière à humecter chaque plante, ou partie de plante, dudit support, de manière à ce que la totalité de ladite solution aqueuse ou de l'eau alors pulvérisée soit absorbée par ledit support, ladite étape de pulvérisation étant stoppée lorsque ladite solution aqueuse ou l'eau n'est plus absorbée par ledit support;a step of spraying all or part of a predetermined quantity of an aqueous solution or water on said support so as to moisten each plant, or part of a plant, of said support, so that all of said aqueous solution or water then sprayed is absorbed by said support, said spraying step being stopped when said aqueous solution or water is no longer absorbed by said support;
- une étape de saupoudrage de tout ou partie d'une quantité prédéterminée de ladite poudre de manière à ce que la totalité de ladite poudre alors saupoudrée soit adsorbée sur ledit support, ladite étape de saupoudrage étant stoppée lorsque ladite poudre n'est plus adsorbée sur ledit support;a step of dusting all or part of a predetermined quantity of said powder so that all of said powder then dusted is adsorbed on said support, said dusting step being stopped when said powder is no longer adsorbed on said support;
- si la totalité de la quantité prédéterminée de ladite poudre n'a pas été saupoudrée, recommencer ledit procédé à partir de l'étape de pulvérisation de ladite solution comportant de l'eau sur ledit support, - une étape de séchage dudit complexe formé.if the whole of the predetermined quantity of said powder has not been sprinkled, repeat said method from the step of spraying said solution comprising water on said support, a step of drying said complex formed.
Le procédé consiste ainsi à faire adsorber de façon définitive la poudre comprenant le ou les principes actifs sur le support. Le complexe ainsi obtenu par le procédé selon l'invention est parfaitement stable. La solution aqueuse, ou l'eau, est utilisée pour réaliser l'adhésion. En effet, le support et la poudre possédant un caractère hygroscopique, la solution aqueuse ou l'eau pulvérisée sur le support permet en quelque sorte d'attirer la poudre comprenant les principes actifs.The method thus consists in permanently adsorbing the powder comprising the active ingredient (s) on the support. The complex thus obtained by the process according to the invention is perfectly stable. The aqueous solution, or water, is used to achieve adhesion. Indeed, the support and the powder possessing a hygroscopic character, the aqueous solution or the water sprayed on the support allows to somehow attract the powder comprising the active ingredients.
Il est essentiel de stopper la pulvérisation de la solution aqueuse ou de l'eau lorsque celle-ci n'est plus adsorbée sur ledit support. En effet, lorsque celle-ci se retrouve libre dans le mélangeur elle forme des gouttes sur les parois du mélangeur. La poudre saupoudrée va alors s'agglomérer sur les parois du mélangeur, là où se trouvent les gouttes, et non plus adhérer au support.It is essential to stop the spray of the aqueous solution or water when it is no longer adsorbed on said support. Indeed, when it is found free in the mixer it forms drops on the walls of the mixer. The dusted powder will then agglomerate on the walls of the mixer, where the drops are, and no longer adhere to the support.
Il ne serait pas avantageux de mélanger directement la poudre comprenant les principes actifs et les fragments de plantes séchées. En effet, les systèmes de délivrance selon l'invention sont destinés à la consommation humaine et contiennent des principes actifs possédant une activité fonctionnelle dans le corps humain. Il est ainsi nécessaire que les concentrations en principes actifs dans un tel système de délivrance soient connues et stables au cours du temps. Or, la différence physique, telle que la différence de taille, entre les poudres et les fragments de plantes séchées destinées à la préparation de thés, de tisanes ou toute autre boisson, ne permet pas d'obtenir un mélange stable dans le temps. En effet, la taille de ces fragments de plantes séchées varie entre 1 et 10 mm alors que la taille des particules de poudre est de l'ordre de la centaine de micromètre. Cette seule différence de taille entre ces deux composants aboutit à un phénomène dit de déphasage. Ainsi, au cours des opérations de manipulation, de transport ou de stockage, ces mélanges perdent de leur homogénéité, les poudres, plus fines que les fragments de plantes, migrent dans les parties inférieures du mélange. La conséquence d'un tel phénomène serait que certaines doses de ces mélanges seraient peu concentrées en principes actifs ce qui correspondrait à un sous dosage, alors que d'autres doses seraient, à l'inverse, très concentrées en principes actifs ce qui correspondrait à un surdosage.It would not be advantageous to directly mix the powder comprising the active ingredients and the dried plant fragments. Indeed, delivery systems according to the invention are intended for human consumption and contain active ingredients having a functional activity in the human body. It is thus necessary that the concentrations of active principles in such a delivery system are known and stable over time. Now, the physical difference, such as the difference in size, between the powders and the dried plant fragments intended for the preparation of teas, herbal teas or any other beverage, does not make it possible to obtain a stable mixture over time. Indeed, the size of these dried plant fragments varies between 1 and 10 mm while the size of the powder particles is of the order of one hundred micrometers. This only difference in size between these two components results in a phenomenon called phase shift. Thus, during handling, transport or storage operations, these mixtures lose their homogeneity, the powders, finer than the plant fragments, migrate into the lower parts of the mixture. The consequence of such a phenomenon would be that certain doses of these mixtures would be little concentrated in active principles which would correspond to a sub-dosage, while other doses would, conversely, be very concentrated in active ingredients which would correspond to overdose.
De plus, la poudre est ajoutée uniquement lorsque la surface du support, et non les parois de la cuve, est humectée. De même, afin d'éviter la perte de principes actifs contenus dans la poudre, l'étape de saupoudrage est stoppée lorsque ladite poudre n'est plus adsorbée sur ledit support. Les étapes de pulvérisation et de saupoudrage sont ainsi au besoin répétées, ce qui permet d'une part, de faire adsorber la totalité de la quantité de poudre prévue et, d'autre part, de créer plusieurs couches de poudres.In addition, the powder is added only when the surface of the support, and not the walls of the tank, is moistened. Similarly, in order to avoid the loss of active ingredients contained in the powder, the dusting step is stopped when said powder is no longer adsorbed on said support. The spraying and dusting steps are thus repeated if necessary, which on the one hand makes it possible to adsorb the totality of the quantity of powder provided and, on the other hand, to create several layers of powders.
Le système de délivrance de principes actifs obtenu est structurellement très différent des systèmes de délivrance connus tels que les gélules ou les comprimés. En effet, le support de la poudre est d'origine végétale et ne nécessite donc pas l'ajout de composés chimiques tels que les excipients couramment utilisés dans la fabrication des gélules ou des comprimés. Il ne s'agit pas d'un mélange de composants mais bien d'un complexe car la poudre est adsorbée sur les parties de plantes constituant son support.The active ingredient delivery system obtained is structurally very different from known delivery systems such as capsules or tablets. Indeed, the carrier of the powder is of plant origin and therefore does not require the addition of chemical compounds such as excipients commonly used in the manufacture of capsules or tablets. It is not a mixture of components but a complex because the powder is adsorbed on the plant parts constituting its support.
Selon une caractéristique de l'invention, la quantité prédéterminée de solution aqueuse ou d'eau est comprise entre 2 et 25 % en poids par rapport au poids total de tous les composants utilisés pour former ledit complexe.According to one characteristic of the invention, the predetermined quantity of aqueous solution or water is between 2 and 25% by weight relative to the total weight of all the components used to form said complex.
La quantité de solution aqueuse ou d'eau est une caractéristique importante du procédé. La quantité de solution aqueuse ou d'eau utilisée varie légèrement en fonction du type de support et/ou de poudre utilisée.The amount of aqueous solution or water is an important feature of the process. The amount of aqueous solution or water used varies slightly depending on the type of support and / or powder used.
Selon un mode de réalisation préféré de l'invention, le procédé comporte, de plus, une étape de mélange dudit complexe et d'une quantité prédéterminée de fragments de plantes séchées prévues pour être utilisées en infusion, décoction ou macération, permettant l'obtention d'un mélange homogène. Le mélange obtenu peut être utilisé pour la préparation de thés ou de tisanes, de la même manière que les préparations pour thés et tisanes classiques. Mais contrairement à ces préparations classiques, les mélanges selon l'invention sont enrichis en principes actifs.According to a preferred embodiment of the invention, the method further comprises a step of mixing said complex and a predetermined quantity of dried plant fragments intended to be used in infusion, decoction or maceration, making it possible to obtain a homogeneous mixture. The mixture obtained can be used for the preparation of teas or herbal teas, in the same way as preparations for conventional teas and herbal teas. But unlike these conventional preparations, the mixtures according to the invention are enriched in active principles.
Avantageusement, ledit support est composé de plantes entières, ou parties de plantes, séchées, choisies parmi le groupe comprenant des queues de cerises séchées, des pépins de framboise séchés, des écorces d'orange amères séchées, des écorces de citrons verts séchées et broyées, du gingembre séché et broyé, des graines de pavot séchées, des graines de lin séchées, des graines de cynorhodon séchées, des fruits d'angélique séchés, des feuilles de thé, des feuilles de menthe, ou leurs mélanges. Les plantes, ou parties de plantes, séchées, utilisées comme support sur lequel vient s'adsorber la poudre sont de taille relativement proche de la taille des fragments de plantes séchées destinées à l'infusion, la décoction ou la macération. Lorsque le complexe ainsi formé par le support sur lequel est adsorbé la poudre comprenant le, ou les, principes actifs, est mélangé aux fragments de plantes séchées destinées à la préparation d'infusion, de décoction ou de macération, aucun déphasage n'est observé. Avantageusement, ladite quantité prédéterminée de fragments de plantes séchées prévues pour être utilisées en infusion, décoction ou macération est comprise entre 5 et 95 % en poids par rapport au poids total dudit système de délivrance.Advantageously, said support is composed of whole plants, or parts of plants, dried, selected from the group comprising dried cherry tails, dried raspberry seeds, dried bitter orange peel, dried and crushed limes peel dried and ground ginger, dried poppy seeds, dried flaxseed, dried rosehip seeds, dried angelica fruit, tea leaves, mint leaves, or mixtures thereof. The dried plants or parts of plants used as a support on which the powder is adsorbed are of a size relatively close to the size of the dried plant fragments intended for infusion, decoction or maceration. When the complex thus formed by the support on which is adsorbed the powder comprising, or the active ingredients, is mixed with the dried plant fragments for infusion preparation, decoction or maceration, no phase shift is observed. Advantageously, said predetermined quantity of dried plant fragments intended to be used in infusion, decoction or maceration is between 5 and 95% by weight relative to the total weight of said delivery system.
Selon un mode avantageux de réalisation de l'invention, ladite solution comportant de l'eau comporte, en outre, entre 0,5 et 30 % en poids d'un composé gélifiant. Le composé gélifiant permet de renforcer la cohésion entre la poudre et le support. Avantageusement, ledit composé gélifiant est un additif alimentaire choisi parmi les alginates ou la gélatine, les carraghénanes, ou l'agar-agar.According to an advantageous embodiment of the invention, said solution comprising water comprises, in addition, between 0.5 and 30% by weight of a gelling compound. The gelling compound makes it possible to reinforce the cohesion between the powder and the support. Advantageously, said gelling compound is a food additive chosen from alginates or gelatin, carrageenans, or agar-agar.
Selon un mode de réalisation, ledit procédé comporte, de plus, une étape d'ajout d'entre 1 et 3 % en poids de silice colloïdale par rapport au poids total de tous les composants utilisés pour former ledit complexe, antérieurement à ladite étape de séchage ainsi qu'une étape de tamisage postérieure à ladite étape de séchage. La silice colloïdale facilite la manipulation du système de délivrance et permet d'éviter qu'il s'agglomère. Elle est éliminée par l'étape de tamisage.According to one embodiment, said method further comprises a step of adding between 1 and 3% by weight of colloidal silica with respect to the total weight of all the components used to form said complex, prior to said step of drying and a sieving step subsequent to said drying step. Colloidal silica facilitates the handling of the delivery system and prevents it from clumping together. It is removed by the sieving step.
Selon un mode de réalisation de l'invention, ladite quantité prédéterminée de poudre est comprise entre 5 et 70 % du poids dudit complexe formé et ladite quantité prédéterminée de support est comprise entre 30 et 95 % du poids dudit complexe formé. Le poids total dudit complexe formé correspond à la somme des poids du support et de la poudre, la solution aqueuse, ou l'eau, et la silice étant éliminées lors des étapes de séchage et de tamisage, respectivement.According to one embodiment of the invention, said predetermined quantity of powder is between 5 and 70% of the weight of said complex formed and said predetermined amount of support is between 30 and 95% of the weight of said complex formed. The total weight of said complex formed corresponds to the sum of the weights of the support and the powder, the aqueous solution, or water, and the silica being removed during the drying and sieving steps, respectively.
Selon un mode de réalisation de l'invention, ladite poudre comportant au moins un principe actif est composée d'au moins un extrait sec de plante, notamment d'une plante pouvant être utilisée dans les domaines de la phytothérapie, de la beauté ou du bien-être.According to one embodiment of the invention, said powder comprising at least one active ingredient is composed of at least one dry extract of a plant, in particular a plant that can be used in the fields of herbal medicine, beauty or welfare.
Avantageusement, ladite poudre comportant au moins un principe actif est composée d'un extrait sec de plante choisi parmi le groupe composé d'un extrait sec de pépins de raisin, d'un extrait sec de mélisse, d'un extrait sec de houblon, d'un extrait sec de café vert, d'un extrait sec de guarana, d'un extrait sec de pissenlit, d'un extrait sec de valériane, d'un extrait sec de fleur d'oranger, d'un extrait sec de radis noir, d'un extrait sec de vigne rouge, d'un extrait sec de ginseng, ou leur mélange. Avantageusement encore, ledit extrait sec de plante est obtenu par une méthode de nébulisation.Advantageously, said powder comprising at least one active principle is composed of a dry extract of a plant chosen from the group consisting of a dry extract of grape seeds, a dry extract of melissa, a dry extract of hops, a dry extract of green coffee, a dry extract of guarana, a dry extract of dandelion, a dry extract of valerian, a dry extract of orange blossom, a dry extract of black radish, a dry extract of red vine, a dry extract of ginseng, or their mixture. Advantageously, said dry plant extract is obtained by a nebulization method.
Les extraits secs de plantes utilisés dans le procédé selon l'invention sont préférentiellement obtenus par des procédés d'extraction impliquant les étapes suivantes: récolte des plantes entières, percolation dans de l'eau ou un mélange d'alcool et d'eau, isolation de l'extrait fluide par pressage, obtention des extraits secs par nébulisation, mélange des extraits secs avec de la maltodextrine et broyage.The dry extracts of plants used in the process according to the invention are preferably obtained by extraction processes involving the following steps: harvesting whole plants, percolation in water or a mixture of alcohol and water, insulation of the fluid extract by pressing, obtaining the dry extracts by nebulization, mixing the dry extracts with maltodextrin and grinding.
De tels procédés, connus de l'homme du métier, permettent une plus forte concentration en principes actifs des plantes que des procédés impliquant uniquement des étapes de broyage des plantes en fine poudre.Such methods, known to those skilled in the art, allow a higher concentration of active principles of the plants than processes involving only milling steps of the plants in fine powder.
Selon un mode de réalisation de l'invention, ladite poudre comprend entre 4 et 65 % de maltodextrine. La maltodextrine augmente la stabilité du complexe formé de la poudre adsorbée sur le support.According to one embodiment of the invention, said powder comprises between 4 and 65% of maltodextrin. Maltodextrin increases the stability of the complex formed by the powder adsorbed on the support.
Selon un autre mode de réalisation de l'invention, ladite poudre est composée d'au moins un extrait sec d'algue, tel que le β-carotène, des polysaccharides, des acides aminés, des peptides, des protéines.According to another embodiment of the invention, said powder is composed of at least one solids extract of alga, such as β-carotene, polysaccharides, amino acids, peptides, proteins.
Selon un autre mode de réalisation de l'invention, ladite poudre est composée d'au moins un extrait sec d'origine animale, tel que la gelée royale lyophilisée ou le collagène. Selon un autre mode de réalisation de l'invention, ladite poudre comportant au moins un principe actif est composée d'au moins un extrait sec d'une plante figurant dans la liste de la pharmacopée française, européenne ou internationale.According to another embodiment of the invention, said powder is composed of at least one dry extract of animal origin, such as freeze-dried royal jelly or collagen. According to another embodiment of the invention, said powder comprising at least one active ingredient is composed of at least one dry extract of a plant appearing in the list of the French, European or international pharmacopoeia.
L'invention concerne encore un système de délivrance de principes actifs , par exemple, un complément alimentaire, comprenant un complexe constitué d'un support composé de plantes entières, ou parties de plantes, séchées, et d'une poudre comportant au moins un principe actif adsorbée sur l'ensemble de la surface dudit support, ledit système de délivrance étant obtenu par un procédé tel que décrit précédemment.The invention also relates to a delivery system for active principles, for example a dietary supplement, comprising a complex consisting of a carrier composed of whole plants, or parts of plants, dried, and a powder comprising at least one principle active agent adsorbed on the entire surface of said support, said delivery system being obtained by a method as described above.
Selon un mode de réalisation, ladite poudre dudit système de délivrance de principes actifs comprend entre 4 et 65 % de maltodextrine.According to one embodiment, said powder of said delivery system of active principles comprises between 4 and 65% of maltodextrin.
Les caractéristiques mentionnées ci-dessus, ainsi que d'autres, apparaîtront plus clairement à la lecture de la description suivante d'un exemple de réalisation d'un système de délivrance de principes actifs selon l'invention Exemples de systèmes de délivrance de principes actifs selon l'invention: systèmes de délivrance de principes actifs de plantesThe characteristics mentioned above, as well as others, will appear more clearly on reading the following description of an exemplary embodiment of an active substance delivery system according to the invention. Examples of delivery systems for active principles according to the invention: systems for delivering active principles of plants
Plusieurs systèmes de délivrance de principes actifs de plantes suivants ont été réalisés.Several delivery systems of the following active ingredients of plants have been made.
Exemple 1 : Procédé de fabrication d'un système de délivrance de principes actifs extraits du houblon (Humulus lupulus) et de valériane {Valeriana officinalis).Example 1 Process for the Production of a System for Delivery of Active Ingredients Extracted from Hops (Humulus lupulus) and Valerian {Valeriana officinalis)
Les quantités de chacun des composants utilisés sont données dans le Tableau 1.The quantities of each of the components used are given in Table 1.
Les principes actifs se présentent sous la forme de poudres d'extraits secs de houblon et de valérianes, respectivement. Les poudres d'extraits secs sont mélangées entre elles. L'écorce d'orange amère séchée et broyée est utilisée comme support de la poudre d'extraits secs.The active ingredients are in the form of powders of dried extracts of hops and valerians, respectively. The powders of dry extracts are mixed together. The dried and ground bitter orange peel is used as a support for the dry extract powder.
Tableau 1Table 1
La totalité de la quantité du support, composé de fragments d'écorce d'orange amère broyée et séchée, est disposée dans un mélangeur, par exemple, du type à vis sans fin, à pales ou à turbine. The entire amount of the carrier, consisting of milled and dried bitter orange peel fragments, is placed in a mixer, for example of the worm, blade or turbine type.
La solution aqueuse comprenant 2 % d'alginate de sodium est pulvérisée dans le mélangeur de manière à imbiber d'eau chacun des fragments d'écorce. La surface des fragments d'écorce se retrouve ainsi recouverte d'eau. La pulvérisation est arrêtée lorsque la solution pulvérisée n'est plus absorbée par les fragments d'écorce et se retrouve libre dans le mélangeur. Lors de cette étape de pulvérisation, il se peut que seulement une partie de la quantité totale de solution aqueuse soit pulvérisée. Une simple vérification visuelle permet à l'homme du métier de déterminer à quel moment la solution pulvérisée n'est plus absorbée.The aqueous solution comprising 2% sodium alginate is sprayed into the mixer so as to imbibe each of the bark fragments with water. The surface of the bark fragments is thus covered with water. The spray is stopped when the spray solution is no longer absorbed by the bark fragments and is free in the mixer. In this spraying step, only a portion of the total amount of aqueous solution may be sprayed. A simple visual check allows the skilled person to determine when the spray solution is no longer absorbed.
La poudre d'extraits secs est alors ajoutée dans le mélangeur par saupoudrage.The powder of dry extracts is then added to the mixer by dusting.
La poudre, qui est hygroscopique, va être attirée par l'eau présente à la surface des fragments d'écorce et s'adsorber ainsi sur le support. Le saupoudrage de la poudre est stoppé lorsque la poudre n'est plus adsorbée sur le support et se retrouve libre dans le mélangeur.The powder, which is hygroscopic, will be attracted by the water present on the surface of the bark fragments and thus adsorb on the support. The dusting of the powder is stopped when the powder is no longer adsorbed on the support and is found free in the mixer.
Une nouvelle étape de pulvérisation de la solution aqueuse est alors réalisée afin d'imbiber de nouveau le support, suivie par une nouvelle étape de saupoudrage de la poudre d'extraits secs. Ces deux étapes sont répétées jusqu'à ce que la quantité totale de poudre d'extraits secs soit adsorbée sur le support.A new step of spraying the aqueous solution is then carried out so as to re-soak the support, followed by a new dusting step of the powder of dry extracts. These two steps are repeated until the total amount of dry extract powder is adsorbed onto the support.
Un complexe constitué de la poudre d'extraits secs adsorbée sur le support est ainsi formé, dans lequel chaque fragment d'écorce du support est enrobé par de la poudre.A complex consisting of the powder of dry extracts adsorbed on the support is thus formed, in which each bark fragment of the support is coated with powder.
La quantité de solution aqueuse pulvérisée au total, et au cours de chaque étape de pulvérisation, est une caractéristique importante du procédé. En effet, si une trop grande quantité de solution est pulvérisée dans le mélangeur, une partie de cette solution ne sera pas absorbée par le support et se retrouvera libre, essentiellement sous forme de gouttes sur les parois du mélangeur. Lors de l'étape de saupoudrage, une partie de la poudre d'extraits secs saupoudrée sera attirée par ces gouttes et ne sera pas adsorbée sur le support. Ce phénomène pourrait aboutir à une perte conséquente d'extraits secs. Idéalement, la quantité totale de solution aqueuse pulvérisée est comprise entre 2 et 25 % en poids par rapport au poids total de tous les composants utilisés pour former le complexe. La quantité totale de solution aqueuse dans cet exemple est de 11,2 %. De la silice colloïdale est alors ajoutée au complexe formé, à raison de 2,8 % en poids par rapport au poids total de tous les composants. La silice colloïdale permet de faciliter la manipulation du complexe.The amount of aqueous solution sprayed in total, and during each spraying step, is an important feature of the process. Indeed, if too much of the solution is sprayed into the mixer, part of this solution will not be absorbed by the support and will be free, mainly in the form of drops on the walls of the mixer. During the dusting step, a portion of the dry dust powder dusted will be attracted by these drops and will not be adsorbed on the support. This phenomenon could lead to a consequent loss of dry extracts. Ideally, the total amount of aqueous spray solution is between 2 and 25% by weight based on the total weight of all components used to form the complex. The total amount of aqueous solution in this example is 11.2%. Colloidal silica is then added to the complex formed at 2.8% by weight relative to the total weight of all the components. Colloidal silica makes it easier to handle the complex.
Le complexe est ensuite séché, par exemple dans une étuve, à une température située entre 40 et 50 0C durant 24 à 48 heures.The complex is then dried, for example in an oven, at a temperature between 40 and 50 0 C for 24 to 48 hours.
Après l'étape de séchage, le complexe est soumis à une étape de tamisage sur un tamis de mailles de 1 à 2 mm. Le tamisage permet d'éliminer la silice colloïdale.After the drying step, the complex is subjected to a sieving step on a sieve of mesh of 1 to 2 mm. Sieving eliminates colloidal silica.
A la fin de ces différentes étapes, on obtient le système de délivrance dont la composition figure dans le Tableau 6.At the end of these different steps, the delivery system whose composition is shown in Table 6 is obtained.
Ce système de délivrance est composé pour 55 % de support et pour 45 % d'extraits secs.This delivery system is composed for 55% of support and for 45% of dry extracts.
Exemple 2: Procédé de fabrication d'un système de délivrance de principes actifs extraits de Guarana (Paullinia Cupana) et de gingembre (Zingiber officinale). Les quantités de chacun des composants utilisés sont données dans leEXAMPLE 2 Process for the Production of a System for the Delivery of Active Ingredients Extracted from Guarana (Paullinia Cupana) and Ginger (Zingiber officinale) The quantities of each of the components used are given in the
Tableau 2.Table 2.
Les principes actifs se présentent sous la forme de poudres d'extraits secs de Guarana et de gingembre, respectivement. Les poudres d'extraits secs sont mélangées entre elles. De la racine de gingembre séchée et broyée est utilisée comme support de la poudre d'extraits secs. Tableau 2The active ingredients are in the form of powders of dry extracts of Guarana and ginger, respectively. The powders of dry extracts are mixed together. Dried and ground ginger root is used as a carrier for the dry extract powder. Table 2
Les étapes du procédé de réalisation du système de délivrance de principes actifs extraits de Guarana et de gingembre sont identiques à celles décrites dans l'exemple 1. Le système de délivrance obtenu est composé pour 50 % de support et pour 50 % d'extraits secs (Tableau 6). The steps of the process for producing the active principle delivery system extracted from Guarana and ginger are identical to those described in Example 1. The delivery system obtained is composed of 50% of support and 50% of solids. (Table 6).
Exemple 3: Procédé de fabrication d'un système de délivrance de principes actifs extraits de Guarana {Paullinia Cupana) et de gingembre {Zingiber officinale).Example 3: Process for the manufacture of a system for delivering active principles extracted from Guarana (Paullinia Cupana) and ginger (Zingiber officinale).
Les quantités de chacun des composants utilisés sont données dans leThe quantities of each of the components used are given in the
Tableau 3.Table 3.
Les principes actifs se présentent sous la forme de poudres d'extraits secs de Guarana et de gingembre, respectivement. Les poudres d'extraits secs sont mélangées entre elles. Des feuilles de thé vert séchées sont utilisées comme support de la poudre d'extraits secs.The active ingredients are in the form of powders of dry extracts of Guarana and ginger, respectively. The powders of dry extracts are mixed together. Dried green tea leaves are used as a support for the dry extract powder.
Tableau 3Table 3
Les étapes du procédé de réalisation du système de délivrance de principes actifs extraits de Guarana et de gingembre sont identiques à celles décrites dans les exemples précédents. Le système de délivrance obtenu comprend 50 % de support et 50 % d'extraits secs (Tableau 6).The steps of the process for producing the active principle delivery system extracted from Guarana and ginger are identical to those described in previous examples. The delivery system obtained comprises 50% of support and 50% of dry extracts (Table 6).
Exemple 4: Procédé de fabrication d'un système de délivrance de principes actifs extraits de radis noir (Raphanus sativus).Example 4 Process for the Production of a Delivery System for Active Ingredients Extracted from Black Radish (Raphanus sativus)
Les quantités de chacun des composants utilisés sont données dans le Tableau 4.The quantities of each of the components used are given in Table 4.
Les principes actifs se présentent sous la forme d'une poudre d'extrait sec de radis noir. Des queues de cerise séchées sont utilisées comme support de la poudre d'extraits secs.The active ingredients are in the form of a dry extract powder of black radish. Dried cherry tails are used as a carrier for the dry extract powder.
Tableau 4Table 4
Les étapes du procédé de réalisation du système de délivrance de principes actifs extraits de radis noir sont identiques à celles décrites dans les exemples précédents. Le système de délivrance obtenu comprend 45 % de support et 55 % d'extraits secs (Tableau 6).The steps of the process for producing the active principle delivery system extracted from black radish are identical to those described in the preceding examples. The delivery system obtained comprises 45% of support and 55% of dry extracts (Table 6).
Exemple 5: Système de délivrance de principes actifs extraits du houblon (Humulus lupulus) et de valériane (Valeriana officinalis) comportant des fragments de plantes destinées à l'infusion. Au système de délivrance décrit dans l'exemple 1 sont ajoutés des fragments des feuilles de thé. Le système de délivrance ainsi obtenu est un mélange du complexe formé de morceaux d'écorce d'orange amère sur lesquels est adsorbée la poudre d'extraits secs de houblon et de valériane, et de feuilles de thé. L'étape de mélange est réalisée postérieurement à l'étape de séchage du complexe. Le mélange obtenu est homogène et comprend 25 % du complexe et 75 % de feuilles de thé.EXAMPLE 5 System for delivering active principles extracted from hops (Humulus lupulus) and valerian (Valeriana officinalis) containing plant fragments intended for infusion. To the delivery system described in Example 1 are added fragments of the tea leaves. The delivery system thus obtained is a mixture of the complex of pieces of bitter orange peel on which is adsorbed the powder of dried extracts of hops and valerian, and tea leaves. The mixing step is carried out after the step of drying the complex. The mixture obtained is homogeneous and comprises 25% of the complex and 75% of tea leaves.
Exemple 6: Préparation pour infusion sous forme d'un sachet dosé comprenant un système de délivrance de principes actifs extraits du houblon (Humulus lupulus) et de valériane {Valeriana officinalis)EXAMPLE 6 Preparation for infusion in the form of a dosed sachet comprising a system for delivery of active principles extracted from hops (Humulus lupulus) and valerian {Valeriana officinalis)
Le système de délivrance selon l'exemple 5 peut servir à la préparation de sachets dosés, tel que les sachets dosés connus et utilisés pour la préparation de boissons telles que les thés. Les sachets contiennent, en moyenne, 2 g de produit. La composition détaillée d'un de ces sachets dosés est donnée dans le Tableau 5.The delivery system according to Example 5 can be used for the preparation of dosed sachets, such as the dosed sachets known and used for the preparation of beverages such as teas. The sachets contain, on average, 2 g of product. The detailed composition of one of these dosed sachets is given in Table 5.
Tableau 5Table 5
L'utilisation d'un tel sachet dosé est identique à l'utilisation d'un sachet de thé classique.The use of such a dosed sachet is identical to the use of a conventional tea bag.
Tableau 6: compositions finales des exemples 1 à 4, obtenues après les étapes de séchage et d'élimination de la silice par tamisage. Table 6: Final compositions of Examples 1 to 4, obtained after the steps of drying and removing the silica by sieving.
Exemple 7: Systèmes de délivrance de principes actifs extraits de plantes et comportant de la maltodextrine.EXAMPLE 7 Delivery Systems for Active Ingredients Extracted from Plants and Containing Maltodextrin
Les étapes des procédés de fabrication des systèmes de délivrance de principes actifs extraits des plantes cités dans le Tableau 7 sont identiques à celles décrites dans l'exemple 1. Préalablement, les poudres d'extraits secs utilisées ont été obtenues par des méthodes de nébulisation. Pour ce faire, les plantes entières ont été récoltées, pesées puis soumises à une étape de percolation dans de l'eau, ou un mélange d'eau et d'alcool. Les extraits fluides ont été isolés par pressage des plantes puis microfïltrés. L'eau ou le mélange d'eau et d'alcool a été évaporé par nébulisation. Les extraits secs ainsi préparés ont été mélangés à de la maltodextrine dans les proportions indiquées dans le Tableau 7 puis les mélange ont été broyés. Les poudres obtenues ont été utilisées dans des procédés de préparation de systèmes de délivrance tel que décrit dans l'exemple 1.The steps of the manufacturing processes of the active substance delivery systems extracted from the plants mentioned in Table 7 are identical to those described in Example 1. Previously, the dry extract powders used were obtained by nebulization methods. To do this, the whole plants were harvested, weighed and then subjected to a percolation step in water, or a mixture of water and alcohol. The fluid extracts were isolated by pressing the plants and then microfiltered. The water or the mixture of water and alcohol was evaporated by nebulization. The dry extracts thus prepared were mixed with maltodextrin in the proportions indicated in Table 7 and the mixtures were ground. The powders obtained were used in processes for preparing delivery systems as described in Example 1.
Tableau 7Table 7

Claims

REVENDICATIONS
1) Procédé de fabrication d'un système de délivrance de principes actifs comprenant au moins un complexe constitué d'un support composé de plantes entières, ou parties de plantes, séchées, et d'une poudre comportant au moins un principe actif adsorbée sur l'ensemble de la surface dudit support, caractérisé en ce qu'il comporte une étape de formation dudit complexe comportant les étapes suivantes:1) Process for the manufacture of an active principle delivery system comprising at least one complex consisting of a support consisting of whole plants, or parts of plants, dried, and of a powder comprising at least one active principle adsorbed on the entire surface of said support, characterized in that it comprises a step of forming said complex comprising the following steps:
- une étape de distribution d'une quantité prédéterminée dudit support dans un mélangeur,a step of distributing a predetermined quantity of said support in a mixer,
- une étape de pulvérisation de tout ou partie d'une quantité prédéterminée d'une solution aqueuse ou d'eau sur ledit support de manière à humecter chaque plante, ou partie de plante, dudit support, de manière à ce que la totalité de ladite solution aqueuse ou de l'eau alors pulvérisée soit absorbée par ledit support, ladite étape de pulvérisation étant stoppée lorsque ladite solution aqueuse ou l'eau n'est plus absorbée par ledit support;a step of spraying all or part of a predetermined quantity of an aqueous solution or water on said support so as to moisten each plant, or part of a plant, of said support, so that all of said aqueous solution or water then sprayed is absorbed by said support, said spraying step being stopped when said aqueous solution or water is no longer absorbed by said support;
- une étape de saupoudrage de tout ou partie d'une quantité prédéterminée de ladite poudre de manière à ce que la totalité de ladite poudre alors saupoudrée soit adsorbée sur ledit support, ladite étape de saupoudrage étant stoppée lorsque ladite poudre n'est plus adsorbée sur ledit support;a step of dusting all or part of a predetermined quantity of said powder so that all of said powder then dusted is adsorbed on said support, said dusting step being stopped when said powder is no longer adsorbed on said support;
- si la totalité de la quantité prédéterminée de ladite poudre n'a pas été saupoudrée, recommencer ledit procédé à partir de l'étape de pulvérisation de ladite solution comportant de l'eau sur ledit support,if the whole of the predetermined quantity of said powder has not been sprinkled, repeat said method from the step of spraying said solution comprising water on said support,
- une étape de séchage dudit complexe formé.a step of drying said complex formed.
2) Procédé de fabrication d'un système de délivrance de substance active selon la revendication 1 , caractérisé en ce que la quantité prédéterminée de solution aqueuse ou d'eau est comprise entre 2 et 25 % en poids par rapport au poids total de tous les composants utilisés pour former ledit complexe.2) A method of manufacturing an active substance delivery system according to claim 1, characterized in that the predetermined amount of aqueous solution or water is between 2 and 25% by weight relative to the total weight of all components used to form said complex.
3) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications 1 à 2, caractérisé en ce qu'il comporte de plus une étape de mélange dudit complexe formé et d'une quantité prédéterminée de fragments de plantes séchées prévues pour être utilisées en infusion, décoction ou macération, permettant l'obtention d'un mélange homogène, ladite étape de mélange étant postérieure à ladite étape de séchage.3) A method of manufacturing an active substance delivery system according to any one of claims 1 to 2, characterized in that it further comprises a step of mixing said complex formed and a predetermined amount of fragments of dried plants intended for use in infusion, decoction or maceration, allowing to obtain a homogeneous mixture, said mixing step being subsequent to said drying step.
4) Procédé de fabrication d'un système de délivrance de substance active selon la revendication 3, caractérisé en ce que ladite quantité prédéterminée de fragments de plantes séchées prévues pour être utilisées en infusion, décoction ou macération est comprise entre 5 et 95 % en poids par rapport au poids total dudit système de délivrance.4) A method of manufacturing an active substance delivery system according to claim 3, characterized in that said predetermined amount of dried plant fragments intended for use in infusion, decoction or maceration is between 5 and 95% by weight relative to the total weight of said delivery system.
5) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite solution aqueuse ou l'eau comporte, en outre, entre 0,5 et 30 % en poids d'un composé gélifiant choisi parmi les alginates, la gélatine, les carraghénanes ou l'agar-agar.5) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said aqueous solution or water comprises, in addition, between 0.5 and 30% by weight of a gelling compound chosen from alginates, gelatin, carrageenans or agar-agar.
6) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce qu'il comporte, de plus, une étape d'ajout d'entre 1 et 3 % en poids de silice colloïdale, par rapport au poids total de tous les composants utilisés pour former le complexe, antérieurement à ladite étape de séchage ainsi qu'une étape de tamisage postérieure à ladite étape de séchage.6) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that it comprises, in addition, a step of adding between 1 and 3% by weight of silica colloidal, based on the total weight of all the components used to form the complex, prior to said drying step and a sieving step subsequent to said drying step.
7) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite quantité prédéterminée de poudre est comprise entre 5 et 70 % du poids dudit complexe formé et ladite quantité prédéterminée de support est comprise entre 30 et 95 % du poids dudit complexe formé.7) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said predetermined amount of powder is between 5 and 70% of the weight of said complex formed and said predetermined amount of support is between 30 and 95% of the weight of said complex formed.
8) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ledit support est composé de plantes entières, ou parties de plantes, séchées, choisies parmi le groupe comprenant des queues de cerises séchées, des pépins de framboise séchés, des écorces d'orange amères séchées, des écorces de citrons verts séchées et broyées, du gingembre séché et broyé, des graines de pavot séchées, des graines de lin séchées, des graines de cynorhodon séchées, des fruits d'angélique séchés, des feuilles de thé, des feuilles de menthe, ou leurs mélanges.8) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said support is composed of whole plants, or plant parts, dried, selected from the group comprising tails of dried cherries, dried raspberry seeds, dried bitter orange peel, dried and crushed limeade peel, dried and crushed ginger, dried poppy seeds, dried flaxseed, dried rosehip seeds, dried angelica fruits, tea leaves, mint leaves, or mixtures thereof.
9) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite poudre comportant au moins un principe actif est composée d'au moins un extrait sec de plante, notamment d'une plante pouvant être utilisée dans les domaines de la phytothérapie, de la beauté ou du bien-être ou d'une plante figurant dans la liste de la pharmacopée française, européenne ou internationale.9) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said powder comprising at least one active ingredient is composed of at least one dry extract of plant, in particular of a plant that can be used in the fields of Herbal medicine, beauty or well-being or a plant listed in the French, European or international pharmacopoeia.
10) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite poudre comportant au moins un principe actif est composée d'un extrait sec de plante choisi parmi le groupe composé d'un extrait sec de pépins de raisin, d'un extrait sec de mélisse, d'un extrait sec de houblon, d'un extrait sec de café vert, d'un extrait sec de guarana, d'un extrait sec de pissenlit, d'un extrait sec de valériane, d'un extrait sec de fleur d'oranger, d'un extrait sec de radis noir, d'un extrait sec de vigne rouge, d'un extrait sec de ginseng, ou leur mélange.10) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said powder comprising at least one active ingredient is composed of a plant solids selected from the group consisting of a dry extract of grape seeds, a dry extract of lemon balm, a dry extract of hops, a dry extract of green coffee, a dry extract of guarana, a dry extract of dandelion, a dry extract of valerian, a dry extract of orange blossom, a dry extract of black radish, a dry extract of red vine, a dry extract of ginseng, or their mixture.
11) Procédé de fabrication d'un système de délivrance de substance active selon la revendication 9, caractérisé en ce que ledit extrait sec de plante est obtenu par une méthode de nébulisation.11) A method of manufacturing an active substance delivery system according to claim 9, characterized in that said dry plant extract is obtained by a nebulization method.
12) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite poudre est choisie parmi le groupe composé d'un extrait sec d'algue, tel que le β-carotène, de polysaccharides, d'acides aminés, de peptides, de protéines, d'un extrait sec d'origine animale, tel que la gelée royale lyophilisée ou le collagène.12) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said powder is selected from the group consisting of a dry extract of seaweed, such as β-carotene , polysaccharides, amino acids, peptides, proteins, a dry extract of animal origin, such as freeze-dried royal jelly or collagen.
13) Procédé de fabrication d'un système de délivrance de substance active selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite poudre comportant au moins un principe actif comprend entre 4 et 65 % de maltodextrine.13) A method of manufacturing an active substance delivery system according to any one of the preceding claims, characterized in that said powder comprising at least one active ingredient comprises between 4 and 65% of maltodextrin.
14) Système de délivrance de principes actifs, caractérisé en ce qu'il est obtenu par un procédé selon l'une quelconque des revendications 1 à 13.14) Delivery system of active principles, characterized in that it is obtained by a method according to any one of claims 1 to 13.
15) Système de délivrance de principes actifs selon la revendication 14, caractérisé en ce que ladite poudre dudit système de délivrance de principes actifs comprend entre 4 et 65 % de maltodextrine.15) The active agent delivery system according to claim 14, characterized in that said powder of said active agent delivery system comprises between 4 and 65% of maltodextrin.
16) complément alimentaire comprenant un système de délivrance de principes actifs obtenu par un procédé selon l'une quelconque des revendications 1 à 13. 16) food supplement comprising an active agent delivery system obtained by a method according to any one of claims 1 to 13.
EP08803478A 2007-09-03 2008-09-01 Method of producing a system for delivering active ingredients of plant origin Ceased EP2187870A1 (en)

Applications Claiming Priority (2)

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FR0706153A FR2920276B1 (en) 2007-09-03 2007-09-03 DELIVERY SYSTEM OF ACTIVE INGREDIENTS CONTAINED IN POWDER
PCT/EP2008/061497 WO2009030666A1 (en) 2007-09-03 2008-09-01 Method of producing a system for delivering active ingredients of plant origin

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FR3064480B1 (en) * 2017-03-28 2020-02-28 Laboratoires Nutrisante SOLID COMPOSITION BASED ON LIQUID PLANT EXTRACTS AND ITS PREPARATION METHOD.
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GB1428394A (en) * 1972-06-29 1976-03-17 Unilever Ltd Tea
JPS61209548A (en) * 1985-03-14 1986-09-17 Maruon Yagiotozou Shoten:Goushi Fine grade powdered tea and production thereof
CA2245995A1 (en) * 1997-10-23 1999-04-23 Societe Des Produits Nestle S.A. Tea bag for iced tea
CN1332975A (en) * 2001-07-18 2002-01-30 邱祥平 Health care medicinal tea and preparation process thereof
GB0215067D0 (en) * 2002-06-28 2002-08-07 Unilever Plc Tea manufacture
KR100570301B1 (en) * 2004-01-30 2006-04-12 전라남도 Functional rice coated with powdered tea and method for manufacturing the same
KR100492628B1 (en) * 2005-03-30 2005-06-03 (주)엔돌핀에프앤비 Funtional corn silk tea and method for preparing the same
JP2007228954A (en) * 2006-03-02 2007-09-13 Genichi Takahashi Method for decomposing and mildening nicotine/tar contained in tobacco leaf

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