EP2187732A4 - TRANSGENIC CHICKEN WITH INACTIVED ENDOGENIC GENLOCUS - Google Patents

TRANSGENIC CHICKEN WITH INACTIVED ENDOGENIC GENLOCUS

Info

Publication number
EP2187732A4
EP2187732A4 EP08797925A EP08797925A EP2187732A4 EP 2187732 A4 EP2187732 A4 EP 2187732A4 EP 08797925 A EP08797925 A EP 08797925A EP 08797925 A EP08797925 A EP 08797925A EP 2187732 A4 EP2187732 A4 EP 2187732A4
Authority
EP
European Patent Office
Prior art keywords
endogenous gene
gene locus
inactivated endogenous
transgenic chickens
chickens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08797925A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2187732A1 (en
Inventor
De Lavoir Marie-Cecile Van
Philip Albert Leighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synageva Biopharma Corp
Original Assignee
Origen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Origen Therapeutics Inc filed Critical Origen Therapeutics Inc
Publication of EP2187732A1 publication Critical patent/EP2187732A1/en
Publication of EP2187732A4 publication Critical patent/EP2187732A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP08797925A 2007-08-14 2008-08-14 TRANSGENIC CHICKEN WITH INACTIVED ENDOGENIC GENLOCUS Withdrawn EP2187732A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96489107P 2007-08-14 2007-08-14
PCT/US2008/073214 WO2009023800A1 (en) 2007-08-14 2008-08-14 Transgenic chickens with an inactivated endogenous gene locus

Publications (2)

Publication Number Publication Date
EP2187732A1 EP2187732A1 (en) 2010-05-26
EP2187732A4 true EP2187732A4 (en) 2012-11-07

Family

ID=40351167

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08797925A Withdrawn EP2187732A4 (en) 2007-08-14 2008-08-14 TRANSGENIC CHICKEN WITH INACTIVED ENDOGENIC GENLOCUS

Country Status (7)

Country Link
EP (1) EP2187732A4 (ja)
JP (3) JP5760159B2 (ja)
KR (1) KR101563017B1 (ja)
CN (1) CN101868144A (ja)
AU (1) AU2008286791A1 (ja)
CA (1) CA2706224A1 (ja)
WO (1) WO2009023800A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012162422A2 (en) * 2011-05-24 2012-11-29 Crystal Bioscience Inc. Transgenic chicken comprising an inactivated immunoglobulin gene
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
BR112018003778A2 (pt) * 2015-08-27 2018-09-25 Crystal Bioscience Inc animal transgênico para produção de anticorpos que apresenta uma cadeia leve comum
KR20200088805A (ko) * 2017-09-19 2020-07-23 더 스테이트 오브 이스라엘, 미니스트리 오브 애그리컬처 & 루럴 디벨로프먼트, 애그리컬처럴 리서치 오거니제이션, (에이.알.오.), 볼카니 센터 게놈-편집 조류
CN110484549B (zh) * 2018-04-20 2023-10-03 北京大学 基因组靶向修饰方法
CA3128360A1 (en) * 2019-03-05 2020-09-10 Yuval CINNAMON Genome-edited birds
WO2023127903A1 (ja) * 2021-12-28 2023-07-06 国立大学法人北海道大学 始原生殖細胞が富化された胚を調製する方法
CN115120382A (zh) * 2022-05-26 2022-09-30 广东省农业科学院动物科学研究所 一种鸡生殖前体细胞移植受体的制备方法
CN115191404B (zh) * 2022-07-28 2023-04-21 四川省畜牧科学研究院 提高黄羽肉鸡后代公鸡比例的新品种选育方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060075513A1 (en) * 1997-10-16 2006-04-06 Avigenics, Inc. Avian transgenesis and exogenous proteins
WO2006084035A2 (en) * 2005-02-01 2006-08-10 Origen Therapeutics, Inc. Transgenic chickens
US20060236418A1 (en) * 2003-02-26 2006-10-19 Babraham Institute Genetically modified non-human mammals and cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1852925A (zh) * 2003-07-15 2006-10-25 人类多克隆治疗公司 人源化免疫球蛋白基因座

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060075513A1 (en) * 1997-10-16 2006-04-06 Avigenics, Inc. Avian transgenesis and exogenous proteins
US20060236418A1 (en) * 2003-02-26 2006-10-19 Babraham Institute Genetically modified non-human mammals and cells
WO2006084035A2 (en) * 2005-02-01 2006-08-10 Origen Therapeutics, Inc. Transgenic chickens

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALLEN BRYAN G ET AL: "Transgenic Xenopus laevis embryos can be generated using phi C31 integrase", NATURE METHODS, vol. 2, no. 12, December 2005 (2005-12-01), pages 975 - 979, XP009163110, ISSN: 1548-7091 *
HOLLIS ROGER P ET AL: "Phage integrases for the construction and manipulation of transgenic mammals", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, BIOMED CENTRAL LTD, GB, vol. 1, no. 1, 7 November 2003 (2003-11-07), pages 79, XP021009350, ISSN: 1477-7827, DOI: 10.1186/1477-7827-1-79 *
LEIGHTON PHILIP A ET AL: "Genetic modification of primordial germ cells by gene trapping, gene targeting, and phi C31 integrase", MOLECULAR REPRODUCTION AND DEVELOPMENT, WILEY-LISS, INC, NEW YORK, NY, US, vol. 75, no. 7, 1 July 2008 (2008-07-01), pages 1163 - 1175, XP002604337, ISSN: 1040-452X, [retrieved on 20080122], DOI: 10.1002/MRD.20859 *
See also references of WO2009023800A1 *
VAN DE LAVOIR MARIE-CECILE ET AL: "Germline transmission of genetically modified primordial germ cells", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 441, no. 7094, 1 June 2006 (2006-06-01), pages 766 - 769, XP009093457, ISSN: 0028-0836, DOI: 10.1038/NATURE04831 *

Also Published As

Publication number Publication date
KR20100088125A (ko) 2010-08-06
JP5760159B2 (ja) 2015-08-05
KR101563017B1 (ko) 2015-10-23
JP6004290B2 (ja) 2016-10-05
AU2008286791A1 (en) 2009-02-19
WO2009023800A1 (en) 2009-02-19
JP2016129519A (ja) 2016-07-21
CN101868144A (zh) 2010-10-20
JP2014239702A (ja) 2014-12-25
EP2187732A1 (en) 2010-05-26
JP2010536346A (ja) 2010-12-02
CA2706224A1 (en) 2009-02-19

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Owner name: SYNAGEVA BIOPHARMA CORP.

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