EP2170242A2 - Système de contrôle de la prise de médicaments - Google Patents

Système de contrôle de la prise de médicaments

Info

Publication number
EP2170242A2
EP2170242A2 EP08758928A EP08758928A EP2170242A2 EP 2170242 A2 EP2170242 A2 EP 2170242A2 EP 08758928 A EP08758928 A EP 08758928A EP 08758928 A EP08758928 A EP 08758928A EP 2170242 A2 EP2170242 A2 EP 2170242A2
Authority
EP
European Patent Office
Prior art keywords
blister
blister pack
cover film
patient
cover
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08758928A
Other languages
German (de)
English (en)
Inventor
Michael Kiy
Hans Layer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amcor Flexibles Kreuzlingen AG
Original Assignee
Alcan Technology and Management Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcan Technology and Management Ltd filed Critical Alcan Technology and Management Ltd
Publication of EP2170242A2 publication Critical patent/EP2170242A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/30—Compliance analysis for taking medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0472—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers of the count-down type, i.e. counting down a predetermined interval after each reset
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging

Definitions

  • the invention relates to a system for reminding a patient of a medi kamenteneinddling and review of drug withdrawal by the patient from a blister pack.
  • Known push-through or blister packs consist of a blister base part and a cover foil which is sealed against the blister bottom part and closes the pack.
  • a blister pack known for metered packaging of pharmaceutical products, such as tablets usually has a multiplicity of individual small containers in the form of cup-shaped depressions formed in the bottom blister in the blister bottom part for receiving the tablets. To remove a single tablet from a blister pack, the corresponding recess is pressed in the bottom part and in this case the tablet pushed through the lid material.
  • the cover sheet is an aluminum foil or a composite foil of an aluminum foil with further layers of plastic or paper.
  • the aluminum foil is a preferred lidding material for blister packs, since at the selected thicknesses of the lid materials relatively low breaking forces are necessary, the required piercing energy is thus low and the aluminum has a low elongation.
  • the bottom part of the blister pack made of plastic, such as PVC, polyamide, polyolefin, polyethylene terephthalate and from at least one of these materials constructed, optionally also containing an aluminum foil composite films.
  • plastic blister films wherein the blistering property of the plastic film is achieved by embedding fillers in the matrix.
  • the fillers are selected with regard to their composition and proportion in such a way that a weakening of the surrounding plastics occurs matrix, whereby the puncture resistance of the film is lowered so that the packaged goods can push through tearing or breaking the film through them. Due to the requirement that the selection of the fillers and in particular their proportions in the plastic matrix should ensure the puncture property of the film, opaque push-through films always resulted.
  • EP-A-0 613 832 discloses a metal foil-free cover sheet comprising at least one polyolefin or polyester-based thermoplastic film having a filler content of 5 to 50% by weight.
  • Preferred plastic is polyethylene
  • fillers are, for example, chalk and talc.
  • a transparent push-through foil with a polyolefin-containing polymer phase is known.
  • the polymer phase contains a hydrocarbon resin component in dissolved form with pendant cyclic groups on the polymer chain.
  • Preferred polyolefins are polyethylene, polypropylene or a co- or terpolymer of ethylene and / or propylene.
  • filler such as chalk or talc, may be embedded in the polymer composition.
  • a control, memory and motivation of patients can significantly increase the success of a therapy and thus lead to a reduction in costs.
  • All previous systems available on the market detect an opening of the packaging, which is also considered as taking the medication. If then the drug is really taken, can not be determined with most conventional systems. As a rule, however, a patient only bothers to open a package if he really wants to take the medication.
  • Some packages help the patient to take the medication by visibly displaying the time (e.g., days of the week) on the package from the outside.
  • Printed conductors arranged directly on the blister pack are disclosed, for example, in US Pat. No. 4,616,316, US Pat. No. 4,617,557, EP 0 972 507 A1, EP 0 129 785 A1 and US2007 / 0084746 A1.
  • the blister pack with the tracks are connected to dataloggers, which record every change of the contacts and record the time of the change. The data is usually read out at the end, thus controlling the time of taking it. Even systems without data output are known; they will issue warnings and instructions when not taking proper medication via a display.
  • a major disadvantage of the known systems are the required electronic components and batteries, which are usually for reasons of cost and lack of environmental compatibility no disposable items.
  • the use of mobile telephones for the memory of a medicament intake is disclosed in DE 100 46 762 A1.
  • the invention has for its object to provide a system of the type mentioned, which allows reliable control of the drug intake without costly adaptation of the blister packs to the system and requires no electronic components and batteries to the blister pack.
  • a system which comprises:
  • a blister pack comprising a blister bottom portion having at least one container formed from a bottom sheet, containing a tablet or like medication portion and a push-through cover sheet sealed against the blister sheet portion,
  • Drug withdrawal with software for evaluating each shot and recognizing the removed tablets by comparison with previous shots of the same blister pack,
  • input and output means cooperating with the communication means for receiving information and for transmitting information.
  • the software for displaying reminder messages through the communication Onsstoff is configured to take medication, with each withdrawn tablet recorded as the time of ingestion and the next reminder message is displayed according to a given timely intake rule.
  • the communication means is preferably a mobile phone with integrated camera.
  • an RFID tag may be arranged on the blister pack, and the communication means is preferably a mobile phone with integrated camera and is equipped with NFC (Near Field Communication). fitted.
  • NFC Near Field Communication
  • a pattern may be printed on the blister pack, preferably circumferentially on the edge of the blister base part or the cover film.
  • the cover film and the blister base part are preferably designed so that they can be distinguished by a brightness or color contrast. Depending on the contrast difference, the picture can be taken from the side of the cover foil or from the side of the bottom foil.
  • the image recognition on the side of the cover sheet may be e.g. become safer if a light area on otherwise dark background is printed over the containers with the tablets.
  • a white frame on the cover foil helps to orient the software.
  • the image can also be taken from the side of the Blister foundedteils, with particularly white tablets stand out well against a dark cover sheet. When the tablet is ejected, it is possible to see residues of the cover foil or a non-white background through the resulting hole.
  • LF low frequency, 125kHz
  • HF 13.56 MHz
  • RFID antennas are well suited if the antenna is very compact.
  • UHF RFID antennas are usually very small dipoles and also very well suited. The removal of medicines from the blister package usually already causes the destruction of a very small part of the RFID antenna, which drastically alters its resonance frequency.
  • RFID tags are mostly passive systems, that is, they are only active if there is enough electromagnetic radiation above the RFID antenna to build up a sufficiently high operating voltage. Passive RFID tags therefore do not require a battery and are available on demand. Upon activation, the RFID tags return information in the form of a number as an individual identification code to the RFI D reader.
  • the RFID antennas can not be applied directly to a metal surface, as this would dampen the electromagnetic radiation too much, and spacers would have to be used when using conventional aluminum foil as a cover foil
  • the problem can be solved by using a nonmetallic cover film, as known from DE 196 13 960 A1, for example, although the known metal foil-free cover films have the disadvantage that However, without these additives, the brittleness of these films is too low for use as printable cover films.
  • the invention is therefore based on the further object of providing a non-metallic cover film which is suitable for sealing against all common floor materials, which is transparent and at the same time has a brittleness which has comparable through-pressure properties with a conventional push-through foil containing aluminum foil.
  • the invention is therefore based on the further object of providing a metal foil-free cover film which is suitable for sealing against all common floor materials, which is transparent and at the same time has a brittleness which has comparable through-pressure properties with a conventional push-through film containing aluminum foil, and suitable for printing on RFID antennas with electrically conductive colors.
  • the cover film contains at least one layer of cycloolefin copolymer (COC).
  • Cycloolefin copolymer is a highly transparent material with excellent barrier to water vapor transmission, can be coextruded with other materials such as polyethylene or polypropylene and is also very brittle. These properties provide ideal conditions for the use of cycloolefin copolymer (COC) for the production of push-through films. It is possible with this material fürdschreibfolien with fürdrückeigen- shafts similar to the produced in large quantities mainly made of aluminum foil of a thickness of 20 microns fürdschreibfolien.
  • the cover film is preferably provided in layers on the side facing against the blister side with a hot-sealing lacquer layer or a coextruded heat seal, the seal to blister base made of PVC, ACLAR ®, PP, PE, PS, Formpack ® or PA.
  • the cover film has a preferred thickness of 5 to 60 .mu.m, in particular 10 to 30 .mu.m.
  • the blister bottom part consists of a material whose chemical structure is compatible with that of the plastic film sealed against the blister bottom part.
  • Examples of materials used to make blister sheet parts are films of PVC, PVDC, PP, PET, PE, PS; PA and composite films such as PVC / ACLAR® (PCTFE), PVC / PVDC and COC or FORMPACK® (AI-AI BIister).
  • both the cover foil and the bottom foil can be printed.
  • an image-based evaluation method is used by using an electronic camera installed in a mobile telephone.
  • Image-recognizing software evaluates a blister pack image to be taken by the patient with the camera and thereby detects one or more tablet samples by comparison with previous evaluations.
  • the blister pack is advantageously sealed with a sealed film foil printed in relation to the tablets with high brightness or color contrast, so that the tablets are clearly distinguishable by the transparent containers.
  • the distinction can also be achieved by patterns, colors or structures on the tablets and / or on the sealing film.
  • Another software supports the control of the patient's medication intake by recording the withdrawn tablets as time of taking and according to the Pharograms ma constitutions is reminiscent of the further intake. If necessary, the software may initiate further actions if, for example, the medication is not taken, too late or too early, and, if necessary, indicate instructions and measures for the patient.
  • the software may be implemented by known methods, e.g. via an SMS link, download to a personal computer, input of an Internet address, etc. transferred to the mobile phone.
  • Another possibility of software installation or activation is the integration of an RFID tag in the blister pack.
  • a mobile telephone equipped with NFC Near Field Communication
  • NFC Near Field Communication
  • This one-to-one ID number is automatically matched by the mobile phone with NFC technology to a central database and thus leads to a feedback from the pharmaceutical manufacturer to the mobile phone.
  • the authenticity of the blister pack can be reconfirmed by the manufacturer.
  • corresponding programs or program modules can be loaded on the mobile phone.
  • the software may include enhanced functionality by detecting additional RFID tag blister packs that are specifically tailored to the combination of drugs for a patient.
  • Other features include including data collected by other devices and transmitted via NFC or Bluetooth, such as blood pressure, heart rate, temperature and more. to be triggered.
  • the software first calculates the distance from the camera and the rotation in space with respect to the central optical acquisition axis by means of a pattern advantageously printed around the edge of the blister pack on the sealing side of the cover foil , This correction is possible via the software known width / length ratio of the blister pack on which the image is first scaled.
  • the position of the tablets in the blister is then interrogated on this normalized image basis, free from the environment.
  • An indication of the recognized, withdrawn tablet for reconfirmation by the patient protects against in principle not absolutely avoidable misrecognitions of the software.
  • the tablet removal is clearly recognized, it is provided with a time stamp and stored in the mobile phone using the RFID identification of the blister pack and the mobile phone ID. This is a one-to-one assignment of removal of a special tablet by a special patient, who is also the owner of the phone, at a unique time possible.
  • FIG. 1 is a plan view of the Blisterteilteil a blister pack.
  • FIG. 2 shows a cross section through the blister pack of FIG. 1 along the line I-I;
  • FIG. - Fig. 3 is a plan view of the cover sheet of the blister pack of
  • FIG. 4 shows a cross section through a first cover sheet
  • FIG. 5 shows a cross section through a second cover film
  • FIG. 6 shows a system for controlling a medication intake.
  • a blister pack 10 shown in FIGS. 1 to 3 consists of a blister base part 12 with a cup-shaped shape formed out of a bottom film Containers 14.
  • the containers 14 are tablets 16.
  • a cover film 18 spanning the openings of the containers 14 is sealed against the blister base part 12.
  • the cover sheet 18 is printed with a pattern (FIG. 3).
  • one of the tablets 16 has already been ejected from its container 14 through the cover film 18.
  • the contrast difference between the open container with the cover sheet removed and the cover sheet 18 printed with a pattern is clearly recognizable for image evaluation.
  • a reference RFID tag 70 a with an RFID chip 72 a and an RFID antenna 74 a is arranged in a non-destructible area on the cover film 18.
  • a first cover film 18 shown by way of example in FIG. 4 consists of a core film 20 of mLLDPE (metallocene-based linear polyethylene lower
  • Heissgueellack für 26 has a thickness of 2 microns, optionally provided with an imprinted outside with a transparent protective lacquer layer 28 of a thickness of 2 microns.
  • a second embodiment of a cover film 18 shown by way of example in FIG. 5 consists of a core film 30 of COC a thickness of 10 microns with coextruded films on both sides of a thickness of 5 microns.
  • An exemplary system shown in FIG. 6 for controlling the taking of a medication or withdrawing a tablet 16 from a blister pack 10 comprises a mobile telephone 42 for receiving and transmitting information, e.g. in the form of SMS (Short Message Service) short messages, via a mobile radio network 44, for example a GSM (Global System for Mobile Communications) or a UMTS (Universal Mobile Telecommunications System) mobile radio network or another mobile radio network, for example a satellite-based mobile radio network or a wireless local area network (WLAN).
  • SMS Short Message Service
  • a mobile radio network 44 for example a GSM (Global System for Mobile Communications) or a UMTS (Universal Mobile Telecommunications System) mobile radio network or another mobile radio network, for example a satellite-based mobile radio network or a wireless local area network (WLAN).
  • GSM Global System for Mobile Communications
  • UMTS Universal Mobile Telecommunications System
  • the system further comprises a computer system 46 having a transceiver unit 48 for transmitting and receiving information over the cellular network 44, a computer unit 50, and a database 52 associated with the computer unit 50 with the stored data including instructions for a patient to take the medication Identification 40 of the blister packs 10th
  • the computer system 46 or the database 52 stores the retrievable software for the mobile telephone 42. This is requested by the mobile telephone 42 and then runs autonomously, for example with a Java program, on the mobile telephone 42.
  • the mobile telephone 42 optionally communicates with it the database 52 and optionally sends medication extraction data or receives additional information from there. LIST OF REFERENCE NUMBERS

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Primary Health Care (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medical Treatment And Welfare Office Work (AREA)

Abstract

La présente invention concerne un système destiné à rappeler à un patient la prise de médicaments et à vérifier la prise de médicaments par le patient par prélèvement dans un emballage sous blister (10). Le système comprend : un emballage sous blister (10) présentant une partie fond de blister (12), au moins un contenant (14) formé à partir d'un film de fond et dans lequel se trouve un comprimé (16) ou une dose médicamenteuse analogue, et un film de recouvrement (18) extrudable scellé contre la partie fond de blister (12); un moyen de communication (42) associé au patient et comprenant une caméra électronique destinée à prendre une image de l'emballage sous blister (10) après chaque prise de médicament réussie, un logiciel destiné à évaluer chaque prise de vue et à reconnaître les comprimés (16) prélevés par comparaison avec des prises de vue précédentes du même emballage sous blister (10); un moyen de lecture et d'enregistrement de données comprenant des instructions renseignant le patient sur la prise des médicaments; et éventuellement un moyen d'entrée et de sortie qui coopère avec le moyen de communication (42) et sert à recevoir et à transmettre des informations.
EP08758928A 2007-06-22 2008-06-02 Système de contrôle de la prise de médicaments Withdrawn EP2170242A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH10042007 2007-06-22
PCT/EP2008/004359 WO2009000383A2 (fr) 2007-06-22 2008-06-02 Système de contrôle de la prise de médicaments

Publications (1)

Publication Number Publication Date
EP2170242A2 true EP2170242A2 (fr) 2010-04-07

Family

ID=39031017

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08758928A Withdrawn EP2170242A2 (fr) 2007-06-22 2008-06-02 Système de contrôle de la prise de médicaments

Country Status (2)

Country Link
EP (1) EP2170242A2 (fr)
WO (1) WO2009000383A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2483221A (en) * 2010-08-24 2012-03-07 Graham Howieson Mobile phone and camera for dose recognition
DE102011010308A1 (de) * 2011-02-03 2012-08-09 Udo Simon Verfahren zur Entnahmekontrolle von medizinischen oder pharmazeutischen Erzeugnissen aus einer geordneten Verpackung
TWI692356B (zh) * 2018-08-10 2020-05-01 玉沛 陳 藉由行動裝置實現的藥片服用輔助方法
CN110827933A (zh) * 2018-08-14 2020-02-21 陈玉沛 借由移动装置实现的药片服用辅助方法
BR202020003089U2 (pt) * 2020-02-13 2021-08-24 Smartpills Serviços De Informação Ltda Dispositivo porta-blíster conectado a um servidor externo

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WO1997014157A1 (fr) * 1995-10-07 1997-04-17 Img Group Limited Composant de circuit electrique forme par impression directe d'un liquide conducteur sur un substrat
DE19852602A1 (de) * 1998-11-14 2000-05-18 Thomas Wagner Vorrichtung und Verfahren zur Erinnerung an eine zeitgerechte Einnahme von Medikamenten
DE29918709U1 (de) * 1999-10-23 2000-01-20 Riek Siegfried Handy mit Schaltung mit welcher Medikamente virtuell verwaltet und über ein Signal zur Einnahme gemeldet werden können
US20080135446A1 (en) * 2004-07-20 2008-06-12 Schreiner Group Gmbh & Co. Kg Product Carrier Strip
EP1933801A2 (fr) * 2005-09-02 2008-06-25 Kort, Willem Theo Plaquette alveolaire dotee d'un systeme de surveillance de contenu (otcm) a composants electroniques polymeres imprimes
EP1775117A1 (fr) * 2005-10-12 2007-04-18 Alcan Technology & Management Ltd. Stratifié formable à froid pour la fabrication de sections de fond de blisters
WO2007060588A1 (fr) * 2005-11-23 2007-05-31 Koninklijke Philips Electronics N.V. Systeme de controle d’un distributeur de medicament

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Also Published As

Publication number Publication date
WO2009000383A3 (fr) 2009-04-02
WO2009000383A2 (fr) 2008-12-31

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