WO2009000382A1 - Système de contrôle de la prise de médicaments - Google Patents

Système de contrôle de la prise de médicaments Download PDF

Info

Publication number
WO2009000382A1
WO2009000382A1 PCT/EP2008/004358 EP2008004358W WO2009000382A1 WO 2009000382 A1 WO2009000382 A1 WO 2009000382A1 EP 2008004358 W EP2008004358 W EP 2008004358W WO 2009000382 A1 WO2009000382 A1 WO 2009000382A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
blister pack
medication
blister
information
Prior art date
Application number
PCT/EP2008/004358
Other languages
German (de)
English (en)
Inventor
Michael Kiy
Wolfgang Lohwasser
Original Assignee
Alcan Technology & Management Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcan Technology & Management Ltd. filed Critical Alcan Technology & Management Ltd.
Priority to EP08758927A priority Critical patent/EP2160170A1/fr
Publication of WO2009000382A1 publication Critical patent/WO2009000382A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/30—Compliance analysis for taking medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2203/00—Decoration means, markings, information elements, contents indicators
    • B65D2203/10—Transponders

Definitions

  • the invention relates to a system for reminding a patient of a medication intake and checking the withdrawal of medication by the patient from a blister pack.
  • Known push-through or blister packs consist of a blister base part and a cover foil which is sealed against the blister bottom part and closes the pack.
  • a blister pack known for metered packaging of pharmaceutical products, such as tablets usually has a multiplicity of individual small containers in the form of cup-shaped depressions formed in the bottom blister in the blister bottom part for receiving the tablets. To remove a single tablet from a blister pack, the corresponding recess is pressed in the bottom part and in this case the tablet pushed through the lid material.
  • the cover sheet is an aluminum foil or a composite foil of an aluminum foil with further layers of plastic or paper.
  • the aluminum foil is a preferred lidding material for blister packs, since at the selected thicknesses of the lid materials relatively low breaking forces are necessary, the required piercing energy is thus low and the aluminum has a low elongation.
  • the bottom part of the blister pack made of plastic, such as PVC, polyamide, polyolefin, polyethylene terephthalate and from at least one of these materials constructed, optionally also containing an aluminum foil composite films.
  • a control, memory and motivation of patients can significantly increase the success of a therapy and thus lead to a reduction in costs.
  • All previous systems available on the market detect an opening of the packaging, which is also considered as taking the medication. If then the drug is really taken, can not be determined with most conventional systems. As a rule, however, a patient only bothers to open a package if he really wants to take the medication.
  • Some packages help the patient to take the medication by visibly displaying the time (e.g., days of the week) on the package from the outside.
  • Printed conductors arranged directly on the blister pack are disclosed, for example, in US Pat. No. 4,616,316, US Pat. No. 4,617,557, EP 0 972 507 A1, EP 0 129 785 A1 and US2007 / 0084746 A1.
  • the blister pack with the tracks are connected to dataloggers, which record every change of the contacts and record the time of the change. The data is usually read out at the end, thus controlling the time of taking it.
  • Systems without data output are known; they will issue warnings and instructions when not taking proper medication via a display.
  • the invention has for its object to propose a system of the type mentioned, which requires no electronic components and batteries to the blister.
  • a system which comprises:
  • a storage medium for storing instructions for patients to take medicines and for storing the identifiers of the blister pack or for storing means for generating the identifiers
  • system according to the invention comprises
  • a blister pack comprising a blister bottom portion having at least one receptacle formed from a bottom film, containing a tablet or like medication portion and a push-through cover film sealed against the blister bottom portion, a receptacle associated with each receptacle, printed on the blister bottom portion and / or on the coversheet visible to the patient after opening the container visible individual identifier,
  • a first communication means associated with the computer of the database for receiving information and comparing the received information with the information stored in the database, and transmitting information to an information receiver, and
  • a second communication means associated with the patient for receiving information from the first communication means and optionally for the transmission of information to the first communication means.
  • the computer is preferably configured to perform the following steps:
  • the second communication means is preferably a mobile telephone.
  • system according to the invention comprises
  • a storage medium storing instructions for patients taking medication and an algorithm for generating the identifiers of the blister pack
  • a display means associated with the patient for communicating instructions and information to the patient.
  • the data containing the instructions and information for a patient to The use of medication and the algorithm for generating the identifications of the push-through pack by means of software are preferably stored on a mobile telephone.
  • the identification code can consist of an alphanumeric and alphanumeric SMS for manual input and transmission.
  • the identification code can consist of a one- or two-dimensional barcode.
  • the identification code can be printed on the blister base part or on the cover sheet.
  • the inventive solution is easy to apply to blister packs and does not require electronic components and batteries on the packaging.
  • the core of the invention is a hidden on the packaging attached, for example, composed of digits and / or letters individual identification. Only after opening the packaging, or better after opening the packaging and removing the tablet, the identifier for the patient is visible.
  • the identifier may be attached in different encodings besides numbers and letters e.g. a one- or two-dimensional barcode.
  • the tag may be attached by printing (e.g., by inkjet) the outside of a transparent bottom sheet prior to forming the containers holding the tablets. In this way, any contact of the ink with the drug is excluded. Subsequently, the identifier is externally, e.g. covered with a non-transparent varnish or a wrapping made of paper strips.
  • Another possibility for attaching the identifier on Blisterteil offers itself in aluminum / PVC composite films (Formpack ® ).
  • Formpack ® aluminum / PVC composite films
  • the identifiers are aligned in the register printing process so that they are arranged in the bottom of the containers after forming in the Blisterteilteil and visible when the packaging is open.
  • Another possibility of an identifier offer a printed barcode or other machine-readable characters that are visible only after opening the packaging.
  • the position of the identifier associated with each receptacle of a blister pack is selected to be readily visible to the patient from the side of the coversheet after opening the container and after removing the tablet.
  • the identifier is attached to the bottom of the containers, the print being provided on one of the two film surfaces or also inside a film laminate, depending on the transparency of the film material selected for the production of the blister base parts. In principle, it is also possible to attach the identifier to the inside of the cover film.
  • identifiers inside the containers of a blister pack must be different. Ideally, identifiers of numbers still contain a check digit in order to exclude accidental typing. In addition, a number can be printed on the blister pack, from which the other numbers can be determined using an algorithm. However, this algorithm should not be publicly available.
  • an example flow may look something like this.
  • the patient receives a box of blister packs, opens the box, removes a blister pack, and follows the instructions printed on it, such as "Send an SMS with the xxxx number to activate these tabs to the number yyyy.”
  • a computer service already knows the order Dosage of medication For example, if the pharmacist has entered the number xxxx and then sends an SMS to the patient at the time of the intended medication, eg: "Please take 1 tablet from the blister xxxx and confirm with the confirmation number" - takes the tablet, presses "answer SMS” on his phone and sends the now visible ID as SMS.
  • the computer service stores the time and tablet information. The whole procedure is then repeated at the time of the next medication. If no medication is taken within a given period of time, the reminder SMS can be sent repeatedly, possibly with some modified content. If a patient stops accepting medication, the computer service can contact the doctor or pharmacist.
  • a software is therefore loaded on the mobile phone.
  • the software reminds the patient to take medication at the scheduled intervals. First, she asks for the number on the blister pack and uses it to generate the numbers hidden as identifiers. The patient enters the number appearing in blister pack after entering the drug, and the software compares this number with the numbers generated. If the numbers are not identical, the software asks you to type the number again.
  • the phone can also respond by sending SMS to a server or establishing a connection to a server via the Internet and storing information there.
  • the numbers can be stored in a barcode.
  • MMS Multimedia Messaging Service
  • the decoding of the barcode is done externally or the mobile phone program is extended by a function to capture barcode and convert it into numbers.
  • numbers may also be in the form of letters. be keyed, which should not be a problem for experienced SMS writers.
  • Points are awarded. These points may be visibly displayed to the patient on the mobile phone, or a reward of the patient may be determined by the points.
  • a significant advantage of the invention is that the blister contains no electronic components.
  • FIG. 1 is a plan view of the Blisterteilteil a blister pack.
  • FIG. 2 shows a cross section through the blister pack of FIG. 1 along the line I-I;
  • - Fig. 3 is a plan view of the cover sheet of the blister pack of
  • FIG. 4 shows a system for controlling a medication intake.
  • a blister pack 10 shown in FIGS. 1 to 3 consists of a blister base part 12 with cup-shaped containers 14 formed out of a bottom film. Tablets 16 are located in the containers 14. The openings of the containers 14 are closed to the containers 14 spanning cover sheet 18 sealed against the blister base 12.
  • Fig. 3 is a now become visible identification identifier in the form of a number recognizable.
  • An exemplary system shown in FIG. 4 for controlling a medication intake or a removal of a tablet 16 from a blister pack 10 comprises a mobile telephone 42 for receiving and transmitting information, eg in the form of short message service (SMS) short message service.
  • a mobile radio network 44 for example a GSM (Global System for Mobile Communications) or a UMTS (Universal Mobile Telecommunications System) mobile radio network or another mobile radio network, for example a satellite-based mobile radio network or a WLAN (Wireless Local Area Network).
  • GSM Global System for Mobile Communications
  • UMTS Universal Mobile Telecommunications System
  • WLAN Wireless Local Area Network
  • the system further comprises a computer system 46 having a transceiver unit 48 for transmitting and receiving information over the cellular network 44, a computer unit 50, and a database 52 associated with the computer unit 50 with the stored data including instructions for a patient to take the medication Identification 40 of the blister packs 10th

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Composite Materials (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un système qui rappelle à un patient de prendre ses médicaments et qui vérifie que le patient a pris ses médicaments dans un emballage perforable (10), le système comprenant : un emballage perforable (10) doté d'une partie de base (12) en blister qui présente au moins un récipient (14) façonné à partir d'une feuille de fond et contenant un comprimé (16) ou une dose similaire de médicaments et une feuille de recouvrement (18) perforable scellée sur la partie de fond (12) en blister, une étiquette individuelle d'identification (40) associée à chaque récipient (14), imprimée sur la partie de fond (12) en blister et/ou sur la feuille de recouvrement (18) et visible pour le patient après l'ouverture du récipient, un moyen de mémoire qui conserve des indications données au patient pour sa prise de médicaments et pour conserver en mémoire les étiquettes d'identification (40) de l'emballage perforable (10) ou pour conserver en mémoire des moyens de formation des étiquettes d'identification (40) et un moyen qui communique avec le moyen de mémoire pour traiter les données conservées dans le moyen de mémoire et communiquer des indications et des informations au patient.
PCT/EP2008/004358 2007-06-22 2008-06-02 Système de contrôle de la prise de médicaments WO2009000382A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08758927A EP2160170A1 (fr) 2007-06-22 2008-06-02 Système de contrôle de la prise de médicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01002/07 2007-06-22
CH10022007 2007-06-22

Publications (1)

Publication Number Publication Date
WO2009000382A1 true WO2009000382A1 (fr) 2008-12-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/004358 WO2009000382A1 (fr) 2007-06-22 2008-06-02 Système de contrôle de la prise de médicaments

Country Status (2)

Country Link
EP (1) EP2160170A1 (fr)
WO (1) WO2009000382A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022098379A1 (fr) * 2020-11-09 2022-05-12 Zakaria Hassan Système d'emballage de médicament sur ordonnance et son procédé d'utilisation pour fournir une gamme d'options de conformité

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028808A1 (de) * 1980-07-30 1982-03-11 Siegfried Dr. 8520 Erlangen Lehrl Verfahren und arzneimittelverpackung zur nachtraeglichen bestimmung der oeffnungszeitpunkte einer arzneimittelverpackung
US4815767A (en) * 1987-12-14 1989-03-28 Patricia Lambert Method and system for documenting and controlling the taking of medication
DE10046762A1 (de) * 1999-10-23 2001-05-23 Siegfried R Riek Handy mit Schnittstelle zur Kommunikation mit einer interaktiven Schaltung mit welcher Medikamente virtuell verwaltet und über ein Signal zur Einnahme gemeldet werden können
WO2007060588A1 (fr) * 2005-11-23 2007-05-31 Koninklijke Philips Electronics N.V. Systeme de controle d’un distributeur de medicament

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028808A1 (de) * 1980-07-30 1982-03-11 Siegfried Dr. 8520 Erlangen Lehrl Verfahren und arzneimittelverpackung zur nachtraeglichen bestimmung der oeffnungszeitpunkte einer arzneimittelverpackung
US4815767A (en) * 1987-12-14 1989-03-28 Patricia Lambert Method and system for documenting and controlling the taking of medication
DE10046762A1 (de) * 1999-10-23 2001-05-23 Siegfried R Riek Handy mit Schnittstelle zur Kommunikation mit einer interaktiven Schaltung mit welcher Medikamente virtuell verwaltet und über ein Signal zur Einnahme gemeldet werden können
WO2007060588A1 (fr) * 2005-11-23 2007-05-31 Koninklijke Philips Electronics N.V. Systeme de controle d’un distributeur de medicament

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022098379A1 (fr) * 2020-11-09 2022-05-12 Zakaria Hassan Système d'emballage de médicament sur ordonnance et son procédé d'utilisation pour fournir une gamme d'options de conformité

Also Published As

Publication number Publication date
EP2160170A1 (fr) 2010-03-10

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