EP2167011A1 - Pochette à chambres multiples destinée à l'utilisation dans la nutrition entérale - Google Patents

Pochette à chambres multiples destinée à l'utilisation dans la nutrition entérale

Info

Publication number
EP2167011A1
EP2167011A1 EP08773501A EP08773501A EP2167011A1 EP 2167011 A1 EP2167011 A1 EP 2167011A1 EP 08773501 A EP08773501 A EP 08773501A EP 08773501 A EP08773501 A EP 08773501A EP 2167011 A1 EP2167011 A1 EP 2167011A1
Authority
EP
European Patent Office
Prior art keywords
chamber
nutrient solution
fluid
bag
enteral nutrient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08773501A
Other languages
German (de)
English (en)
Other versions
EP2167011B1 (fr
Inventor
Irmgard GÖRISCH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Kabi Deutschland GmbH
Original Assignee
Fresenius Kabi Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Deutschland GmbH filed Critical Fresenius Kabi Deutschland GmbH
Publication of EP2167011A1 publication Critical patent/EP2167011A1/fr
Application granted granted Critical
Publication of EP2167011B1 publication Critical patent/EP2167011B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J15/00—Feeding-tubes for therapeutic purposes

Definitions

  • Multi-compartment bag for use in enteral nutrition
  • the invention relates to a multi-compartment bag for use in enteral nutrition containing an enteric nutrient solution.
  • enteral and parenteral nutrition differs from enteral nutrition in that it bypasses the gastrointestinal tract. Therefore, in principle, enteral and parenteral nutrient solutions differ in composition.
  • enteral nutrient solutions must be suitable for covering the energy and nutrient content. They generally contain proteins, carbohydrates, fats, vitamins and minerals. Enteral nutrient solutions may also contain fiber.
  • the industrially produced enteral nutrient solutions are provided as tube feed in rigid or flexible containers.
  • containers serve bottles or bags.
  • the containers have a connection piece for connecting a transfer system, with which the enteral nutrient solution is transferred from the container into the stomach of the patient.
  • the transfer of the nutrient solution can be carried out by gravity or by means of a pump.
  • the known transfer systems have a hose line which has at one end a connector for connection to the connection piece of the nutrient solution container and at the other end a connector for connection to the connection piece of a probe tube.
  • a hose line section is designed as a pump segment, which is inserted into a roller pump. While in enteral nutrition all nutritional components can be provided in a single solution, in parenteral nutrition the food components, especially protein sources, carbohydrates and fats, must be stored separately for stability.
  • EP 0 790 051 B1 describes a pouch for use in parenteral nutrition, which contains a plurality of chambers separated from each other for separately storing the individual food components. Shortly before the administration of the parenteral nutrient solution, a fluid connection is established between the individual chambers, so that the different components can mix with one another.
  • the welds may also be formed as separable or tearable seams. These seams are also called peel seams.
  • Multi-chambered bags for use in parenteral nutrition are also known from EP 0 619 998 B1, EP 0 893 982 B1 and EP 0 883 396 B1.
  • enteral nutritive solutions As storage problems for enteral nutritive solutions generally do not pose stability problems due to the mixture of components, which include protein sources, carbohydrates and fats, there are no known receptacle containers for use in enteral nutrition, which have several compartments for the intake of the components of the enteral Nutrient solution.
  • enteral nutrient solutions alone can not cover the fluid requirement of the patient. Therefore, it is necessary to administer the patient next to the enteral nutrient solution nor a liquid.
  • This liquid can have a lower energy content.
  • water is administered to the patient in addition to the enteral nutrient solution, which has no nutritional value.
  • separate containers are used in the prior art, which are also referred to as hydrobags.
  • a container which is subdivided by a dividing wall into two chambers of equal size.
  • a common outlet opening which is in communication with both chambers.
  • a shut-off or mixing device is connected, with which the liquids contained in the chambers can be removed in the desired dosage or in succession.
  • One chamber is intended to contain an enteral nutrient solution and the other chamber a tea or water.
  • the two chambers should be refilled with enteral nutrient solution or tea or water. Therefore, the chambers each have a filling opening, which can be closed with a lid.
  • the enteric nutrient solution which is packed in tubular bags made of aluminum composite foil protected from light and oxygen, should only be transferred to the container immediately before administration.
  • the invention is based on the object to simplify an enteral nutrition with a sufficient hydration.
  • the container according to the invention for use in enteral nutrition is characterized in that the container is a multi-chamber bag with at least two separate chambers, wherein at least one chamber contains an enteral nutrient solution with a first energy content and at least one chamber with a liquid to cover the fluid requirement contains an energy content that is smaller than the energy content of the enteral nutrient solution. Since with the multi-chamber bag according to the invention both the enteral nutritive solution and the liquid still required to cover the fluid requirement are provided directly, the use in enteral nutrition is simplified. A transfer of liquids from other containers is not required. Both liquids are put together in provided a bag that can easily collapse when emptying and can be produced inexpensively. Since the bag can collapse, aeration of the bag is basically not required. Therefore, there is no increased risk of contamination.
  • a decisive advantage of the multi-chamber bag according to the invention is to provide both the enteric nutrient solution and the liquid to meet the fluid requirement so that the individual requirements of the patient with regard to the composition and amount of the two fluids can be taken into account.
  • either only the enteric nutrient solution from the one chamber can be administered to the patient, or both the enteral nutrient solution and the liquid can be administered to cover the fluid requirement. Both liquids are ready in the multi-chamber bag. If the multi-compartment bag has more than two chambers, different amounts of fluids can be provided, which can be administered depending on the individual needs of the patient. For example, several chambers for enteral nutrient solutions and / or several chambers for liquids may be provided to cover the fluid requirements, which have different volumes and absorb different amounts of fluid. Depending on the individual needs of the patient then only some or all of the chambers are emptied.
  • the enteral nutritive solution has an energy content of at least 0.5 kcal / ml, preferably of at least 0.8 kcal / ml, more preferably of at least 1 kcal / ml, to meet the energy requirement of the patient. It preferably contains a source of protein, carbohydrates and fats. Milk and soya proteins can be used as protein sources. As carbohydrates, polysaccharides and oligosaccharides can be used. Soya, sunflower oils, coconut and milk fats and fish oil, MCT (medium chain triglycerides), palm kernel oil, rapeseed oil and structured triglycerides may be considered as sources of fat.
  • the enteral nutrient solution It is also possible to add vitamins, trace elements and electrolytes as well as roughage.
  • the liquid to cover the fluid requirement differs from the enteral nutrient solution essentially by the lower energy content.
  • the fluid requirement is covered by water.
  • the at least one chamber, which is filled with the enteral nutrient solution preferably has a larger volume than the at least one chamber which is filled with the liquid to cover the fluid requirement.
  • one compartment contains from 750 to 1500 ml enteral nutrient solution while the other compartment contains from 250 to 750 ml of fluid.
  • the multi-chamber bag has means for establishing a fluid connection between the individual chambers containing enteral nutrient solution or fluid to meet the fluid requirement.
  • a single connector is sufficient for both the removal of the enteral nutrient solution and the liquid to cover the fluid requirement.
  • the fluid connection between the chambers can be established and the liquid can be administered instead of the already administered nutrient solution to cover the fluid requirement. Both liquids can basically be mixed in advance.
  • the multi-chamber bag preferably has a hanger to which the container can be hung on a stand or the like. This hanger is arranged on the opposite side of the multi-chamber bag for removing the liquids.
  • An alternative embodiment provides that not only the at least one chamber, which is filled with the enteral nutrient solution, but also the at least one chamber, which is filled with the solution for covering the fluid requirement, having a connector for removing liquid.
  • each chamber may be drained via the respective fitting, with no need to establish fluid communication between the chambers.
  • the multi-chamber bag preferably also has a hanger on the opposite side of the connector for removing the liquid to cover the fluid requirement.
  • a hanger on the opposite side of the connector for removing the liquid to cover the fluid requirement.
  • the multi-chamber bag is provided together with a device for transferring the enteral nutrient solution and / or the liquid to cover the fluid requirement to the patient.
  • the multi-chamber bag and the transfer system are preferably sterile packed in a package.
  • transfer systems it is possible to use all known transfer devices which have a hose line which at one end has a connection piece for the multi-chamber bag and at the other end a connector for an enteral feeding tube.
  • the packaging enclosing the multi-chamber bag and the transfer system is again a bag.
  • the multi-chamber bag can be made from the materials known to those skilled in the art according to known methods.
  • the means for establishing fluid communication between the chambers are preferably formed as separable or tearable seams, called peel seams.
  • the seams separating the individual chambers are non-separable seams.
  • Fig. 1 is a simplified schematic representation of a first
  • Exemplary embodiment of the multi-chamber bag according to the invention for use in enteral nutrition which has two chambers,
  • Fig. 2 shows a second exemplary embodiment of the invention
  • Multi-chamber bag in a schematic representation, which has two chambers,
  • Fig. 3 shows a further exemplary embodiment of the invention
  • Multi-chamber bag which has three chambers
  • Fig. 4 shows an alternative exemplary embodiment of the invention
  • Multi chamber bag with three chambers and
  • Fig. 5 shows an arrangement in a simplified schematic representation, which comprises the multi-chamber bag according to the invention together with a transfer system, wherein the multi-chamber bag and the transfer system are enclosed by a package.
  • Fig. 1 shows a simplified schematic representation of an exemplary embodiment of the multi-chamber bag according to the invention for use in enteral nutrition.
  • the multi-chamber bag according to the invention is a polymeric bag in the present exemplary embodiment.
  • the bag 1 consists in the present embodiment of two superimposed flexible plastic films 2, 3, which are welded at their edges with a peripheral weld 4, which in the position shown in Fig. 1, a lower Section 4A and an upper portion 4B and two lateral portions 4C and 4D.
  • the bag may also consist of a film tube, which is welded at the top and bottom.
  • the bag is divided into a lower chamber 5 and an upper chamber 6.
  • the lower chamber 5 has a larger volume than the upper chamber 6.
  • the lower chamber can accommodate 1500 ml of liquid while the upper chamber can hold 500 ml of liquid.
  • Both chambers 5, 6 are separated from each other by a non-separable weld 7, which runs in the upper third of the bag between the lateral sections 4C, 4D of the circumferential weld 4.
  • the bag 1 has two connecting pieces 8A and 8B, of which one connecting piece 8A is welded into the lower portion 4A of the circumferential weld 4 and the other connecting piece 8B is welded into the upper portion 4B of the circumferential weld 4.
  • a connector for connecting a transfer system to a bag for receiving enteral nutrient solution is known, for example, from EP 1 010 412 A2 or EP 0 830 874 B1, which is expressly incorporated by reference for the purpose of disclosure.
  • Such a connector is also referred to as a port.
  • the connecting pieces 8 A and 8 B each have a pierceable membrane 8 A 'and 8 B', which is shown only hinted.
  • the pierceable membranes seal the two chambers 5, 6 sterile.
  • the bag In the region of the lower portion 4A of the circumferential seam 4, the bag has a lower hanger 9A and in the region of the upper portion 4B of the peripheral weld 4, an upper hanger 9B. Both hangers 9A, 9B are formed as tabs formed on the lower and upper portions of the bag. When Hanger can also serve as recesses in the upper and lower portions of the bag or its welds.
  • the lower chamber 5 with the larger volume is filled with an enteral nutrient solution A containing various components, including a source of protein, carbohydrates and fats.
  • the enteric nutrient solution A alone can not cover the fluid requirement of the patient.
  • the patient requires another fluid B contained in the upper chamber 6.
  • this liquid is water (H 2 O).
  • the enteral nutritive solution A differs from the fluid B for covering the fluid requirements of the patient in that the enteral nutritive solution has a substantially higher energy content than the fluid B for covering the fluid requirement.
  • the enteral nutritive solution has an energy content of at least 0.5 kcal / ml, preferably of at least 0.8 kcal / ml, more preferably of at least 1 kcal / ml, while the liquid has an energy content of less than 0 to cover the fluid requirement. 5 kcal / ml, preferably water which has no energy content.
  • a transfer system 10 which will be described below with reference to FIG. 5, is used to administer the enteral nutrient solution A or the fluid B for fluid balancing.
  • Fig. 5 shows an arrangement comprising the bag 1 and the transfer system 10, wherein the bag and the transfer system are packaged in a package 20 sterile.
  • the package 20 is in turn a bag of superimposed films 12, 13, which are welded together with a circumferential weld 14.
  • the bag 20 may also consist of a film tube which is welded at the top and bottom. At least part of the circumferential weld 14 is formed as a separable or tearable weld (peel seam). Therefore, it is possible to simply rupture the package 20 to remove the bag 1 and the transfer system 10.
  • the transfer system 10 has a hose 11, wherein at the one end of the hose 11, a connector 16 for connecting the transfer system to one of the two connectors 8A, 8B of the bag 1 is provided and at the other end of the hose a connector 23 for connecting the Transfer system is connected to a corresponding connector of a probe tube, not shown, for enteral nutrition.
  • the promotion of liquids can be done by gravity alone. But it can also be used a metering pump.
  • metering pumps are peristaltic peristaltic pumps, in which a hose line section IA of the hose 11 is inserted.
  • the closure member 15 includes a break part 15 A, which is broken to open the tubing, so that a fluid connection is made.
  • the connector 16 of the transfer system is already connected to the lower connector 8A of the bag 1.
  • the transfer system can also be attached to the bag only.
  • the connector 16 of the transfer system has a spike 16 A, with which the membrane 8 A 'and 8 B' of the connecting pieces 8 A or 8 B can be pierced, so that a fluid connection to the two chambers 5, 6 of the bag 1 can be produced.
  • an enteral nutrition and fluid balance can be carried out in a simple manner.
  • the enteral nutrient solution A is supplied from the lower chamber 5 under the influence of gravity or by means of a metering pump via the tubing 11 of the transfer system 10 and the probe tube, not shown, to the patient.
  • the bag is hung on the upper hanger 9B.
  • the bag is turned over and hung on the lower hanger 9A, wherein the connector 16 of the transfer system 10 is connected to the then lower connector 8B, so that the then filled with water B chamber 6 emptied. Both chambers can be emptied at different times without a connection between the chambers. If the administration of additional fluid is not required, the chamber filled with water need not be emptied.
  • the chamber 5 filled with enteral nutrient solution A generally has a larger volume than the chamber 6 filled with water B. However, it is also possible to fill the larger chamber with water and the smaller chamber with enteral nutrient solution.
  • Fig. 2 shows an alternative exemplary embodiment of the two-chamber bag according to the invention.
  • the two-chamber bag 16 of FIG. 2 differs from the bag 1 of FIG. 1 in that the weld 7 separating both chambers 5, 6 is not a permanent seam, but at least in one section as a manually separable or tearable peel seam T is formed.
  • the bag 12 has only in the position shown in Fig. 2 lower connector 8 A and the upper hanger 9 B, but not an upper connector and a lower hanger. Otherwise, the bags 1 and 16 do not differ from each other. Therefore, the same reference numerals are used for the corresponding parts.
  • the bag 12 For application of the enteral nutrient solution, the bag 12 is suspended on the hanger 9B, so that under the influence of gravity or by means of a metering pump, the enteral nutrient solution A from the chamber 5 can be required.
  • the peel seam T is separated by hand, so that the liquid B, for example water, can be administered to the patient. In this embodiment, it is not necessary to turn the bag over and reconnect the connector of the transfer system.
  • FIG. 3 shows a further exemplary embodiment, which differs from the exemplary embodiments described with reference to FIGS. 1 and 2 in that the bag 17 has three chambers.
  • the corresponding parts are again provided with the same reference numerals.
  • 1 differs from the exemplary embodiment of Fig. 1 by a further peel seam 7 "which extends from the permanent seam 7 to the lateral section 4C of the circumferential weld seam 4.
  • the permanent weld 7 and the peel seam 7" share the bag 17 in three chambers 5, 6 and 21.
  • the larger chamber 5 is filled with 1000 ml of enteral nutrient solution A and the smaller chamber 21 with 500 ml of enteral nutrient solution A ', while the smaller chamber 6 is filled with 500 ml of liquid B to cover the fluid requirements, in particular water.
  • the three-chamber bag 17 of Fig. 3 allows a more accurate dosage of the food or liquid needs of the patient than the two-chamber bag 1, 16 of Fig. 1 and Fig. 2.
  • the two-chamber bag 1, 16 of Fig. 1 and Fig. 2 can either only contained in the chamber 5 enteral nutrient solution A or both the nutrient solution A and A 'contained in the chamber 5 and in the chamber 21 are administered.
  • the peel seam 7 "In addition, after the bag has been turned over and the transfer system has been connected to the other connecting piece, the liquid B, in particular water, can be administered to cover the fluid requirement.
  • Fig. 4 shows a further exemplary embodiment of the bag 22, which differs from the exemplary embodiment of Fig. 3 only in that the smaller chamber 21 is not filled with enteral nutrient solution, but with a liquid B 'to cover the fluid requirements, especially water.
  • the bag 22 thus allows application of different amounts of water.
  • the bags 17 and 22 shown in Fig. 3 and Fig. 4 each have two connectors and two hangers. But it is also possible that in analogy to the exemplary embodiment of Fig. 2, the bag of Fig. 3 and Fig. 4 grouting only a connector and a hanger.
  • the permanent seam 7 is to be formed as a separable or tearable peel seam. But it is also possible to form the peel seam T 'as a permanent seam, the bag then has a further connector and another hanger.
  • the bag according to the invention can also have further chambers which are separated from one another by permanent sutures or peel sutures and filled with either an enteral nutrient solution or a liquid for fluid balance of the patient, so that a particularly accurate Adjustment of the food or liquid needs to the individual needs of the patient is possible.
  • the chamber or chambers containing enteric nutrient solution contain enteral nutrient solutions with different compositions.
  • the chamber or chambers containing liquid to cover the fluid requirement to contain different fluids for fluid balance, for example water and, for example, fruit juice on the one hand. But here, too, it is assumed that the energy content of the liquids for fluid balance is smaller than the energy content of the enteral nutrient solutions.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Bag Frames (AREA)

Abstract

L'invention concerne une poche à compartiments multiples à utiliser pour la nutrition entérale, notamment une poche en polymère à compartiments multiples qui présente au moins deux compartiments (5, 6) séparés entre eux. Au moins un des deux compartiments ou davantage contient une solution nutritive entérale (A), tandis que l'autre compartiment contient un liquide (B) destiné à couvrir les besoins en liquide. La solution nutritive entérale présente dans l'un des compartiments possède une plus grande valeur énergétique que le liquide présent dans l'autre compartiment pour maintenir en équilibre le bilan liquide. L'invention concerne en outre un dispositif doté d'une telle poche à compartiments multiples, la poche à compartiments multiples étant enveloppée de façon stérile dans un emballage (20) conjointement avec un système de transfert (10).
EP08773501A 2007-06-21 2008-06-19 Pochette a chambres multiples destinee a l'utilisation dans la nutrition enterale Active EP2167011B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200710028733 DE102007028733A1 (de) 2007-06-21 2007-06-21 Behältnis zur Verwendung in der enteralen Ernährung
PCT/EP2008/004911 WO2008155112A1 (fr) 2007-06-21 2008-06-19 Poche à compartiments multiples à utiliser pour la nutrition entérale

Publications (2)

Publication Number Publication Date
EP2167011A1 true EP2167011A1 (fr) 2010-03-31
EP2167011B1 EP2167011B1 (fr) 2013-01-09

Family

ID=39791176

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08773501A Active EP2167011B1 (fr) 2007-06-21 2008-06-19 Pochette a chambres multiples destinee a l'utilisation dans la nutrition enterale

Country Status (7)

Country Link
US (1) US20100198185A1 (fr)
EP (1) EP2167011B1 (fr)
CN (1) CN101720217B (fr)
DE (1) DE102007028733A1 (fr)
ES (1) ES2401919T3 (fr)
HK (1) HK1138178A1 (fr)
WO (1) WO2008155112A1 (fr)

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DE102017125281A1 (de) 2017-10-27 2019-05-02 Dermatools Biotech Gmbh Vorrichtung zur Bereitstellung einer Haut- oder Wundauflage

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CN104839727A (zh) * 2015-06-05 2015-08-19 南阳市汇博生物技术有限公司 一种医用全营养配方乳剂型食品及其制备方法
KR101964384B1 (ko) * 2017-08-25 2019-04-01 씨제이헬스케어 주식회사 의료용 수액백
KR101964383B1 (ko) * 2017-08-25 2019-04-01 씨제이헬스케어 주식회사 의료용 수액백
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CN101720217B (zh) 2013-07-10
DE102007028733A1 (de) 2008-12-24
HK1138178A1 (en) 2010-08-20
CN101720217A (zh) 2010-06-02
US20100198185A1 (en) 2010-08-05
EP2167011B1 (fr) 2013-01-09
WO2008155112A1 (fr) 2008-12-24
ES2401919T3 (es) 2013-04-25

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