EP2155143B1 - Dispositif d'envoi de fluide dans un récipient - Google Patents

Dispositif d'envoi de fluide dans un récipient Download PDF

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Publication number
EP2155143B1
EP2155143B1 EP07748576.1A EP07748576A EP2155143B1 EP 2155143 B1 EP2155143 B1 EP 2155143B1 EP 07748576 A EP07748576 A EP 07748576A EP 2155143 B1 EP2155143 B1 EP 2155143B1
Authority
EP
European Patent Office
Prior art keywords
container
receptacle
gas
connector
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07748576.1A
Other languages
German (de)
English (en)
Other versions
EP2155143A4 (fr
EP2155143A1 (fr
Inventor
Elisabet Helmerson
Fredrik BÄCKSTRÖM
Anna ELLSTRÖM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carmel Pharma AB
Original Assignee
Carmel Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carmel Pharma AB filed Critical Carmel Pharma AB
Priority to EP15198205.5A priority Critical patent/EP3009121B1/fr
Priority to EP17170133.7A priority patent/EP3222265B1/fr
Priority to EP14175968.8A priority patent/EP2789329B1/fr
Publication of EP2155143A1 publication Critical patent/EP2155143A1/fr
Publication of EP2155143A4 publication Critical patent/EP2155143A4/fr
Application granted granted Critical
Publication of EP2155143B1 publication Critical patent/EP2155143B1/fr
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration

Definitions

  • the invention relates to a device for providing cleaned fluid i.e. gas and/or liquid to a receptacle according to the preamble of claim 1.
  • the invention can be implemented in aseptic preparation of drugs, for example for providing sterilized/cleaned air to a medical receptacle, such as a bottle or vial, with the purpose of drawing a solution or another liquid used in medicine applications out from the medical receptacle.
  • a medical receptacle such as a bottle or vial
  • a known problem associated with the preparation of drug solutions is the fact that medical bottles or vials normally are made of a non-compressible material, such as glass or plastic. To enable the vial to be drained off, air has to flow into the vial so as to avoid negative pressure in the vial which negative pressure would otherwise counteract or prevent further transportation of liquid from the vial to another receptacle such as syringe.
  • a system for providing sterilized gas is disclosed in WO 00/35517 .
  • a flexible bag containing sterilised gas is provided.
  • the bag has an opening covered by a gas and liquid-impervious membrane which can be punctured by a needle in order to draw the sterilised gas out from the bag for further transportation of the gas to a bottle.
  • a bottle connector is arranged on the current bottle and the bottle connector has a pressure compensation means for receiving gas.
  • WO 02/11794 a system for providing cleaned gas is described.
  • This system works with an injection syringe and an air filter to be attached to a connection nozzle of the syringe.
  • the container of the syringe is charged with air which has been forced through the filter so as to clean the air.
  • the air filter is removed and the syringe is connected to a coupling means (injector device) which in turn is connected to a capping means (bottle connector) arranged on a bottle.
  • the capping means has a pressure-equalisation chamber whose volume can vary.
  • the cleaned gas in the syringe is transferred from the syringe to the bottle and to the pressure-equalisation chamber arranged on the capping means. Thereafter the substance in the bottle can be drawn out from the bottle by means of the syringe and the coupling means, while the cleaned gas flows from the pressure-equalisation chamber into the bottle.
  • the prior art system described in WO 02/11794 has drawbacks.
  • the system requires an adapter provided with an air filter being connected to and removed from a syringe in order to fill the pressure-equalisation chamber before the medical substance can be drawn from the bottle.
  • the air filter is fixedly attached to a syringe.
  • a conventional syringe can not be used.
  • the cleaned gas has to be drawn from the environment and subsequently transferred to the bottle and the pressure-equalisation chamber before the medical substance can be drawn from the bottle.
  • WO 2007/120641 discloses a vial adaptor for removing liquid contents from a vial, which includes a piercing member and a bag.
  • the bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial.
  • the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial.
  • a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom.
  • a vial adaptor is coupled with the vial in order to remove the liquid.
  • the bag expands within the vial, and in other embodiments, the bag contracts within the vial.
  • US 5017 186 is directed to a medicament injection adjunct which provides a source of sterile air for loading into a medicament syringe prior to use of the syringe for withdrawing liquid medicament from a multi-dose vial.
  • the disclosure also describes the sequence of steps involved in loading the syringe with sterile air.
  • Embodiments involving inclusion of the adjunct in a tandem medicament package and also use of the adjunct in hospital wards or outpatient areas are also described.
  • WO8404672 concerns a device for ventilating and pressure balancing the interior of a sealed vessel containing a substance which is to be taken out from said vessel e.g. by an injection syringe, the vessel being provided with a closure means comprising a sealing member through which a puncturing member, e.g. a needle can be passed for entering the interior of said vessel.
  • the closure means or a connection means attachable onto said vessel is provided with ventilating means arranged to provide a communication between the interior of the vessel and a closed containeror alternatively the atmosphere via a filter.
  • An object of the invention is to provide a device for providing cleaned and/or sterilized fluid of the kind referred to in the introduction where at least one problem of such prior art devices discussed above is reduced to a substantial extent.
  • the invention aims to indicate how to provide sterilized/cleaned fluid in a rational and safe way during preparation of drugs.
  • the invention is based on the insight that sterilized/cleaned air is advantageously provided by a connector system itself, rather than utilising additional equipments to fill an expansion container comprised in a connector system during drug preparation.
  • a container has to be filled with the fluid either during manufacturing of the device or by the user .
  • the object is achieved by a device according to claim 1.
  • a connector and a container which form an integrated unit, wherein the connector is provided with a first means for connection to a receptacle, and the integrated unit is provided with a filter for cleaning fluid passing the filter during filling the container with fluid, for example before connection of the connector to a receptacle, no syringe provided with an air filter adapter or an air filter fixedly attached to the syringe is needed for transferring cleaned fluid into for example a vial before conveyance of a substance out of the vial. Instead a conventional syringe can be used for conveyance of a substance out from the receptacle as soon as the connector is arranged on the receptacle.
  • a cleaned fluid suitable for aseptic preparation of drugs can be achieved by filtering the fluid.
  • the device 1 can be used for providing cleaned and/or sterilized gas, for example air, to a receptacle and thereby facilitate conveyance of a substance out of the receptacle.
  • a substance can be various solutions and liquids constituting drugs, for example cytotoxic drugs and antibiotics, for use in the field of medicine.
  • the device comprises a connector 2 and a container 3 which form an integrated unit 4.
  • the connector 2 is provided with a first means 5 for connection to a receptacle or in other words a first connector portion 5 for connection to a receptacle.
  • the container 3 is pre-filled or adapted to be pre-filled with a cleaned and/or sterilized gas to be transferred from the container 3 to a receptacle, which is connectable with the connector 2, during conveyance of a substance out of the receptacle.
  • a medicine receptacle such as a bottle or vial 6, and the exploded view in figure 4 .
  • pre-filled is meant the container being already filled with gas before it is used for providing gas to a receptacle.
  • the device is already filled when delivered to the user, and preferably the container is filled during or after manufacture of the device for example just before or at the moment when the device is enclosed by a package or packing.
  • cleaned gas is meant that the gas has been filtered by a filter to remove particles and/or viable micro-organisms to such an extent that the gas is classified to be aseptic and accepted by the relevant authority and/or any standards.
  • the degree of purity can be expressed in the largest particles allowed to pass the filter for a given flow rate of gas. In, some cases no or very few particles having a size exceeding 5 ⁇ m are allowed to be present in the cleaned gas. However, the allowed particle size is determined by the requirements in the current application. Some drug treatments require that substantially all particles having a size exceeding 0.15 ⁇ m are removed from the gas by the particulate air filter. As an example, a filter with the mesh size 0.2 ⁇ m can be used to remove substantially all particles and micro organisms of that size or larger.
  • sterilized gas By the expression “sterilized” gas is meant that the gas has been subjected to a sterilization method to remove viable micro-organisms, which method is accepted for the current product by the relevant authority.
  • Current regulations in Europe for medical devices to be designated “STERILE” may be found in the European standard EN 556-1. Other regulations may exist in other countries.
  • the sterilization can be ethylene oxide sterilization, sterilisation by irradiation, or (moist) heat sterilization or any other accepted method.
  • the European standard requirements imply that the theoretical probability of there being a viable micro-organism present on/in the sterilized device shall be equal to of less than 1x10 -6 .
  • the gas is sterilized, it is not always necessary to clean the gas according to the cleaning process as described above, although such cleaning and the sterilization can be combined. However, other methods can be used to remove particles etc. from the gas if required or the sterilization process itself may be sufficient to bring the gas into a state where the gas is to be considered as both cleaned and sterilized.
  • the first connection means 5 can be designed for connection to a receptacle, such as the neck of a vial.
  • the first connection means 5 is constituted by a ring-shaped portion 7 for enclosing the neck 8 of the vial 6.
  • the ring-shaped portion 7 has slits 9 so as to form flanges 10 which protrude downwardly.
  • the flanges 10 can be provided with hooks 11 or barbs for gripping around the neck.8 of the vial 6.
  • the connector 2 is suitably provided with a second means 12 for connection to a transfer member 13 (see figures 3 and 4 ), such as an injector device to be interconnected with the connector, for conveyance of a substance out of the receptacle 6.
  • the connector 2 is suitably provided with a second connector portion 12.
  • the second connection means 12 can comprise a luer lock coupling or bayonet coupling to enable an injector device to be connected to the connector.
  • both the injector device and the connector are provided with a membrane so as to create a double membrane coupling between the injector and the current device.
  • the amount of gas, preferably air, provided by the pre-filled container should be adapted to the volume of the receptacle which is to be drained off.
  • the volume of the gas when being in the receptacle should preferably correspond to the volume of the receptacle so as to enable the receptacle to be completely drained off. This implies that the volume of the cleaned or sterilized gas in the pre-filled container is preferably approximately equal to or larger than the volume of the receptacle provided that the pressure of the gas is substantially the same in the receptacle as in the container.
  • the volume of the gas should be in the interval 1-100 cm 3 at atmospheric pressure.
  • the connector 2 is preferably provided with a piercing member, such as a hollow needle 14 (as illustrated) for penetration of a closing (not illustrated) made of rubber for instance, which closing covers the opening of a receptacle 6, such as a vial.
  • a piercing member such as a hollow needle 14 (as illustrated) for penetration of a closing (not illustrated) made of rubber for instance, which closing covers the opening of a receptacle 6, such as a vial.
  • the expression “needle” is meant to comprise spikes and similar components for penetration of such a closing in order to create a channel between the container 3 and the receptacle 6 to which the connector 2 is connected.
  • gas contained in the container 3 can be transferred from the container to the receptacle 6, i.e. gas can flow from the container 3 to the receptacle 6.
  • the connector 2 and the container 3 form an integrated unit 4. This implies that the connector and the container are made in one piece or the connector 2 and the container 3 can be coupled to each other so as to form an integral unit 4. Different types of coupling means known from prior art can be used as long as an airtight, or at least a substantially airtight connection can be obtained between the current components 2, 3.
  • the volume of the container 3 can be variable so as to allow the gas to flow from the container 3 to a receptacle 6.
  • the container 3 is suitably made of a compressible material to make the volume of the container variable.
  • the container can comprise a first portion 17 made by a relatively rigid material which first portion 17 is coupled to the connector 2, and a second portion 18 made by a relatively flexible material attached to the first portion 17.
  • the container 3 can be designed to have a flexible portion, such as a bellow which is compressible and extendable.
  • the container, or the flexible portion of the container comprises a displaceable spring-loaded element, such as an axial spring-loaded element, that is arranged to allow fluid to flow into the container/ flexible portion of the container.
  • the displaceable spring-loaded element is for example constrained between two flanged ends of the flexible portion.
  • the spring(s) of the pring-loaded element When the flexible portion is empty the spring(s) of the pring-loaded element is/are highly compressed. As the flexible portion is filled with fluid the spring(s) of the spring-loaded element become(s) less compressed.
  • the spring(s) may be arranged on the inside or outside of the flexible portion or they may be integrally formed with the flexible portion.
  • the displaceable spring-loaded element may be arranged to be disconnected from the container/flexible portion of the container once the container/flexible portion of the container has been filled to the desired amount.
  • the flexible portion of the container may be arranged to be detachable from the remaining part of the container, whereby the flexible portion may be filled with fluid before and/or after it has been attached to the remaining part of the container.
  • the volume of the container 3 can be increased and decreased, respectively.
  • the device illustrated in figure 1 comprises a compressible container
  • the container can have a cylinder and a piston arranged therein so as to enable the volume of the container to be changed.
  • the container comprises locking means to prevent fluid from flowing into the container, during the transportation of the device, for example, or at any other time when the device is not in use.
  • the container 3 can be pressurized by cleaned or sterilized gas to cause an overpressure in the container.
  • An overpressure allows gas to flow from the container 3 to a receptacle 6 connected to the connector and the container.
  • the overpressure is suitably adapted to the size of the receptacle to which the connector is to be connected to ensure the receptacle can be completely drained off in a subsequent step.
  • the pressure in the filled container can be for example in the interval from 1 atm to 2atm.
  • the device comprises any means, such as a valve, for allowing the gas to flow from the container after the device has been connected to the receptacle and during conveyance of a substance out of the receptacle.
  • a device 1' according to the invention is illustrated.
  • the device can be used for providing cleaned gas to a receptacle and thereby facilitate conveyance of a substance out of the receptacle.
  • a substance can be various solutions and liquids constituting drugs, for example cytotoxic drugs or antibiotics, for use in the field of medicine.
  • the device comprises a connector 2' and a container 3' which form an integrated unit 4'.
  • the connector 2' is provided with a first means 5' for connection to a receptacle 6' or in other words a first connector portion 5'. See also figure 7 illustrating the device connected to a medicine bottle or vial 6', and the exploded view in figure 8 .
  • the first connection means 5' can be designed for connection to a bottle, such as the neck of a vial.
  • the first connection means 5' is constituted by a ring-shaped portion 7' for enclosing the neck 8' of the vial 6'.
  • the ring-shaped portion 7' has slits 9' so as to form flanges 10' which protrude downwardly.
  • the flanges 10' can be provided with hooks 11' or barbs for gripping around the neck 8' of the vial 6'.
  • the connector 2' is suitably provided with a second means 12' for connection to a transfer member 13', such as an injector device to be interconnected with the connector, for conveyance of a substance out of the receptacle 6'.
  • a transfer member 13' such as an injector device to be interconnected with the connector, for conveyance of a substance out of the receptacle 6'.
  • the connector 2' is suitably provided with a second connector portion 12'.
  • the second connection means 12' can comprise a luer lock coupling or bayonet coupling to enable an injection device to be connected.
  • both the injector device and the connector are suitably provided with a membrane so as to create a double membrane coupling between the injector and the current device.
  • the connector 2' is preferably provided with a piercing member, such as a hollow needle 14' (as illustrated) for penetration of a closing (not illustrated) made of rubber for instance, which closing covers the opening of a receptacle 6, such as a vial.
  • a piercing member such as a hollow needle 14' (as illustrated) for penetration of a closing (not illustrated) made of rubber for instance, which closing covers the opening of a receptacle 6, such as a vial.
  • the expression “needle” is meant to comprise spikes and similar components for penetration of such a closing in order to create a channel between the container 3' and the receptacle 6' to which the connector 2' is connected.
  • a channel or passage 15' in the needle 14' gas contained in the container 3' can be transferred from the container to the receptacle 6', i.e. gas can flow from the container 3' to the receptacle 6'.
  • the connector 2' and the container 3' form an integrated unit 4'.
  • Different types of coupling means 16' known from prior art can be used as long as an airtight or at least a substantially airtight connection can be obtained between the current components 2', 3'.
  • the container 3' has to be filled with gas before connection of the connector 2' to a receptacle 6'.
  • the volume of the container 3' is preferably variable.
  • the container can comprise a first portion 17' made by a relatively rigid material which first portion is coupled to the connector 2', and a second portion 18' made by a relatively flexible material attached to the first portion 17'.
  • the second portion 18' can be extensible by manipulation of for example a handle 20' arranged at the end of the container 3'.
  • the volume of the container 3' can be increased and decreased, respectively.
  • the container 3' can be designed to have a flexible portion, such as a bellow which is compressible and extendable by affecting the container manually.
  • the container 3' is preferably provided with said handle 20' for regulating the volume of the container 3'.
  • the volume of the container is preferably variable as illustrated, there may be other ways to fill the container while at the same time ensuring the gas passes a filter 21'.
  • the gas container could be constituted by a sealed vacuum-packed flexible bag whose seal can be broken to allow gas to flow into the bag.
  • the gas container is rigid or semi-rigid and pressurized gas is used to fill the container.
  • the amount of gas, preferably air, provided by the pre-filled container, should bye adapted to the volume of the receptacle which is to be drained off.
  • the volume of the gas when being in the receptacle should preferably correspond to the volume of the receptacle so as to enable the receptacle to be completely drained off. This implies that the volume of the cleaned or sterilized gas in the pre-filled container is preferably approximately equal to or larger than the volume of the receptacle provided that the pressure of the gas is substantially the same in the receptacle as in the container.
  • the volume of the gas should be in the interval 1-100 cm 3 at atmospheric pressure.
  • the integrated unit 4' is provided with the filter 21', such as a particulate air filter for cleaning gas passing the filter 21' during filling the container 3' with gas, preferably by increasing the volume of the container 3', before connection of the connector 2' to a receptacle 6'.
  • the filter hereinafter called particulate air filter 21'
  • the particulate air filter 21' can be arranged in different ways, according to the embodiment illustrated in figure 5 and 6 the particulate air filter 21' is arranged on the connector 2'.
  • the particulate air filter 21' is arranged to be removed from the integrated unit 4' after the container 3' has been filled with cleaned gas. Subsequently to filling the container 3' the particulate air filter 21' is removed and the connector 2' is to be connected to the receptacle 6'.
  • cleaned gas is meant that the gas has been filtered by a filter to remove particles and/or viable micro-organisms to such an extent that the gas is classified to be aseptic and accepted by the relevant authority and/or any standards.
  • the degree of purity can be expressed in the largest particles allowed to pass the filter for a given flow rate. In some cases no or very few particles having a size exceeding 5 ⁇ m are allowed to be present in the cleaned gas. However, the allowed particle size is determined by the requirements in the current application. Some drug treatments require that substantially all particles having a size exceeding 0.15 ⁇ m are removed from the gas by the particulate air filter. As an example, a filter with the mesh size 0.2 ⁇ m can be used to remove substantially all particles and micro organisms of that size or larger.
  • the particulate air filter 21' is preferably designed as a needle shield 22' for the tip of needle 14'.
  • the filter can be arranged to at least partially cover or surround the tip of the needle 14'. This implies that the particulate air filter 21' cleans the gas and at the same time the particulate air filter 21' functions as a protection during handling of the device 1'. Furthermore, such a needle tip shield 22' protects the sterile package enclosing the device during transport and storage of the device.
  • any contamination particles removed from the gas and collected in the particulate air filter 21' are removed from the integrated unit 4'.
  • one and the same channel can be used for both filling the container 3' with cleaned gas and transferring the cleaned gas from the container 3 to a receptacle 6'.
  • the particulate air filter 21' has to be arranged so as to avoid contamination during transportation of the gas from the container 3' to the receptacle 6'.
  • the integrated unit 4' can be provided with a first channel 23' for filling the container 3' with cleaned gas and a second channel 15' for transferring the cleaned gas to a receptacle. Otherwise, i.e.
  • the particulate air filter if the particulate air filter is to be left, and one and the same channel is used for transportation of gas in both directions; the particles collected in the particulate air filter could possibly release from the particulate air filter and be unintentionally brought into the receptacle 6' by the gas flow.
  • Such a contamination can be prevented by providing a removable air filter or by providing different openings/channels for transportation of gas into and out of the container 3', respectively.
  • a lid 26' can be arranged on the integrated unit 4' for covering the particulate air filter 21' so as to prevent further communication between the interior of the integrated unit 4' and the environment via the particulate air filter 21' after filling the container 3'. Firstly, the container 3' is filled with the cleaned gas and thereafter the lid 26' is mounted on the integrated unit 4' to cover the particulate air filter 21' and prevent further gas transportation through the air particle filter 21'. Thereafter, the integrated unit 4' and the receptacle 6' are to be interconnected and the subsequent manipulations can be safely executed.
  • the lid 26' has the function of preventing transportation of liquid, gas or any vapour in the direction from the integrated unit 4' to the environment so as to counteract that any undesired substance in the receptacle 6' escapes to the environment.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (6)

  1. Dispositif (1) destiné à faciliter le transfert d'une substance hors du réceptacle, comprenant un raccord (2) et un conteneur (3) qui forment une unité intégrée (4), le raccord (2) comprend un premier moyen (5) destiné à assurer un raccordement au réceptacle (6),
    caractérisé en ce que le volume du conteneur (3) est variable et le conteneur (3) est conçu de manière à présenter une partie flexible, dans lequel le conteneur (3) est préalablement rempli avec un fluide purifié c'est-à-dire, un gaz et/ou un liquide à transférer à partir du conteneur vers un réceptacle lorsque ledit dispositif (1) est délivré à un utilisateur, lequel réceptacle peut être raccordé au premier moyen (5) dudit raccord (2) au cours du transfert d'une substance à partir du réceptacle (6), de telle sorte que le transfert d'une substance à partir du réceptacle (6) peut être réalisé dès que le raccord (2) est agencé sur le réceptacle (6), et de telle sorte que ledit conteneur (3) ou ladite partie flexible dudit conteneur (3) comprend un élément chargé par ressort, pouvant être déplacé, qui comporte un ou plusieurs ressorts contraints entre deux extrémités comportant un rebord de ladite partie flexible, lequel élément chargé par ressort est agencé de manière à permettre à un fluide de s'écouler dans ledit conteneur (3) ou ladite partie flexible dudit conteneur (3), de telle sorte que ledit ou lesdits ressorts sont agencés de manière à être compressés lorsque ladite partie flexible est vide, et à devenir moins compressés lorsque ladite partie flexible est remplie de fluide.
  2. Dispositif selon la revendication 1, caractérisé en ce que le fluide est stérilisé.
  3. Dispositif selon la revendication 1 ou 2, caractérisé en ce que le conteneur (3) est réalisé en un matériau compressible pour rendre variable le volume du conteneur.
  4. Dispositif selon l'une quelconque des revendications précédentes, dans lequel le conteneur (3) comprend un moyen de verrouillage destiné à empêcher l'écoulement du fluide dans le conteneur (3).
  5. Dispositif selon la revendication 1, caractérisé en ce que le conteneur (3) est pressurisé par un fluide purifié ou stérilisé afin de provoquer une surpression dans le conteneur, laquelle surpression est adaptée à la taille du réceptacle sur lequel le raccord doit être raccordé.
  6. Dispositif selon l'une quelconque des revendications précédentes, caractérisé en ce que le raccord (2) comporte un second moyen (12) destiné à assurer le raccordement à un élément de transfert (13) afin d'assurer le transfert d'une substance hors d'un réceptacle (6).
EP07748576.1A 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient Active EP2155143B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP15198205.5A EP3009121B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP17170133.7A EP3222265B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP14175968.8A EP2789329B1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SE2007/050416 WO2008153460A1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient

Related Child Applications (4)

Application Number Title Priority Date Filing Date
EP15198205.5A Division EP3009121B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP14175968.8A Division EP2789329B1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient
EP14175968.8A Division-Into EP2789329B1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient
EP17170133.7A Division EP3222265B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle

Publications (3)

Publication Number Publication Date
EP2155143A1 EP2155143A1 (fr) 2010-02-24
EP2155143A4 EP2155143A4 (fr) 2013-08-14
EP2155143B1 true EP2155143B1 (fr) 2015-08-19

Family

ID=40129933

Family Applications (4)

Application Number Title Priority Date Filing Date
EP07748576.1A Active EP2155143B1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient
EP17170133.7A Active EP3222265B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP15198205.5A Active EP3009121B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP14175968.8A Active EP2789329B1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP17170133.7A Active EP3222265B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP15198205.5A Active EP3009121B1 (fr) 2007-06-13 2007-06-13 Dispositif pour fournir un fluide à un réceptacle
EP14175968.8A Active EP2789329B1 (fr) 2007-06-13 2007-06-13 Dispositif d'envoi de fluide dans un récipient

Country Status (5)

Country Link
EP (4) EP2155143B1 (fr)
JP (1) JP5091313B2 (fr)
CA (2) CA2924477C (fr)
ES (4) ES2600952T3 (fr)
WO (1) WO2008153460A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
CA3176437A1 (fr) 2011-08-18 2013-02-21 Icu Medical, Inc. Adaptateurs pour flacons destines a reguler la pression
US9707335B2 (en) 2011-09-02 2017-07-18 Unitract Syringe Pty Ltd Drive mechanism for drug delivery pumps with integrated status indication
AU2012301834B2 (en) 2011-09-02 2016-04-21 Unitract Syringe Pty Ltd Insertion mechanism for a drug delivery pump
US9814832B2 (en) 2011-09-02 2017-11-14 Unl Holdings Llc Drive mechanism for drug delivery pumps with integrated status indication
US11173244B2 (en) 2011-09-02 2021-11-16 Unl Holdings Llc Drive mechanism for drug delivery pumps with integrated status indication
AU2012301784B2 (en) 2011-09-02 2017-02-16 Unitract Syringe Pty Ltd Drive mechanism for drug delivery pumps with integrated status indication
EP2731643B2 (fr) 2011-09-13 2019-06-05 Unitract Syringe Pty Ltd Raccord de voie de fluide stérile à des récipients à médicament pour pompes de libération de médicament
WO2013142618A1 (fr) 2012-03-22 2013-09-26 Icu Medical, Inc. Adaptateurs de flacon à régulation de pression
US9579258B2 (en) 2012-04-02 2017-02-28 Kobayashi & Co., Ltd. Drug delivery device
WO2013150579A1 (fr) 2012-04-02 2013-10-10 株式会社メディカルクリエーション Dispositif d'administration de médicament
CA2881306A1 (fr) 2012-08-29 2014-03-06 Unitract Syringe Pty Ltd Mecanismes d'entrainement d'administration commandee pour pompes d'administration de medicament
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
ES2966008T3 (es) * 2013-01-23 2024-04-17 Icu Medical Inc Adaptadores de vial de regulación de presión
AU2013375293B2 (en) 2013-01-25 2018-08-23 Unitract Syringe Pty Ltd Integrated sliding seal fluid pathway connection and drug containers for drug delivery pumps
USD723157S1 (en) 2013-03-12 2015-02-24 Unitract Syringe Pty Ltd Drug delivery pump
EP3021814A4 (fr) 2013-07-19 2017-08-09 ICU Medical, Inc. Systèmes et procédés de transfert de fluides à pression régulée
CA2953229C (fr) 2014-06-20 2024-01-02 Icu Medical, Inc. Adaptateurs pour flacons destines a reguler la pression
MX2017004005A (es) 2014-09-29 2017-06-08 Unitract Syringe Pty Ltd Mecanismo de insercion para aguja rigida para una bomba para el suministro de un farmaco.
AU2016235138B2 (en) * 2015-03-26 2018-07-26 Enable Injections, Inc Pressurized gas powered medicament transfer and re-suspension apparatus and method
JP2019503256A (ja) 2016-01-29 2019-02-07 アイシーユー・メディカル・インコーポレーテッド 圧力調節バイアルアダプタ
MX2019001580A (es) 2016-08-08 2019-06-20 Unl Holdings Llc Dispositivo y metodo para conectar un canal de flujo de fluidos y dispositivos de administracion de farmacos que incorporan dichos dispositivos.
EP3518860A4 (fr) 2016-09-30 2020-06-10 ICU Medical, Inc. Dispositifs et procédés d'accès à un flacon à régulation de pression
US11224555B2 (en) 2018-04-23 2022-01-18 Hospira, Inc. Access and vapor containment system for a drug vial and method of making and using same
BR112022008072A2 (pt) * 2019-10-31 2022-08-02 Nacatur Int Import Export S R L Conjunto de segurança para a reconstituição, ingestão e infusão de líquidos farmacológicos

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5841966Y2 (ja) * 1979-04-27 1983-09-22 株式会社 ミドリ十字 医療用移注用具
SE434700B (sv) * 1983-05-20 1984-08-13 Bengt Gustavsson Anordning for lufttet overforing av substans fran ett kerl till ett annat
JPH0829793B2 (ja) * 1987-11-07 1996-03-27 大阪エヤゾール工業株式会社 押出し容器
US5017186A (en) * 1989-07-11 1991-05-21 Arnold Victor A Device and method for maintaining sterility of multi-dose medicament vials
SE513225C2 (sv) 1998-12-03 2000-08-07 Carmel Pharma Ab Arrangemang, förfarande och gasbehållare för steril eller aseptisk hantering
SE517084C2 (sv) 2000-08-10 2002-04-09 Carmel Pharma Ab Förfarande och anordningar vid aseptisk beredning
JP2002238979A (ja) * 2001-02-16 2002-08-27 Jms Co Ltd 両頭針
US6715520B2 (en) * 2001-10-11 2004-04-06 Carmel Pharma Ab Method and assembly for fluid transfer
CA2628339C (fr) * 2005-11-07 2015-04-28 Industrie Borla S.P.A. Adaptateur de fiole aere manipulable sans danger
ES2568265T3 (es) 2006-04-12 2016-04-28 Icu Medical, Inc. Adaptadores de vial y viales para regular la presión

Also Published As

Publication number Publication date
JP5091313B2 (ja) 2012-12-05
CA2707342A1 (fr) 2008-12-18
EP3222265A1 (fr) 2017-09-27
ES2550675T3 (es) 2015-11-11
EP2789329B1 (fr) 2016-08-03
EP3009121B1 (fr) 2017-05-10
EP2789329A1 (fr) 2014-10-15
ES2600952T3 (es) 2017-02-13
WO2008153460A1 (fr) 2008-12-18
EP2155143A4 (fr) 2013-08-14
CA2924477C (fr) 2019-05-14
EP3009121A1 (fr) 2016-04-20
CA2707342C (fr) 2016-06-07
JP2010528810A (ja) 2010-08-26
ES2772838T3 (es) 2020-07-08
EP3222265B1 (fr) 2020-01-08
EP2155143A1 (fr) 2010-02-24
CA2924477A1 (fr) 2008-12-18
ES2627304T3 (es) 2017-07-27

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