EP2144651A1 - Dispositif destiné à maintenir une canule et à être mis en place de manière amovible sur un stylo d'injection - Google Patents

Dispositif destiné à maintenir une canule et à être mis en place de manière amovible sur un stylo d'injection

Info

Publication number
EP2144651A1
EP2144651A1 EP08758055A EP08758055A EP2144651A1 EP 2144651 A1 EP2144651 A1 EP 2144651A1 EP 08758055 A EP08758055 A EP 08758055A EP 08758055 A EP08758055 A EP 08758055A EP 2144651 A1 EP2144651 A1 EP 2144651A1
Authority
EP
European Patent Office
Prior art keywords
latching means
base body
counter
cannula
locking means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08758055A
Other languages
German (de)
English (en)
Inventor
Michael Hartmann
Jürgen Fuchs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
Original Assignee
B Braun Melsungen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Publication of EP2144651A1 publication Critical patent/EP2144651A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/348—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub snap lock, i.e. upon axial displacement of needle assembly

Definitions

  • Designation Device for holding a cannula and for detachable arrangement on an injection pen
  • the invention relates to a device for holding a cannula and for detachable arrangement on a Injetationspen according to the preamble of claim 1.
  • Penkanüle device for holding a cannula has distributed over the shell periphery of its hollow cylindrical body webs extending from the proximal towards the distal end of the body, the webs open in a bead formed as a rise, which at the distal end the entire shell circumference of the body is formed.
  • the webs depressions are formed over the outer circumference of the body. These depressions begin at the proximal end of the body and extend toward its distal end without reaching the distal end.
  • the webs and depressions thus formed are used to solve a Penkanüle used by a Injetechnischspen and at the same time dispose of in a corresponding disposal container.
  • the Penkanüle be disposed of it is inserted into an opening of the disposal container, which corresponds approximately to the dimension of the Penkanüle.
  • Corresponding elements which form a negative image of the webs and depressions of the penkanule are arranged on this part of the opening at a partial circumference to the webs and depressions of the penkanule.
  • the injection pen is therefore inserted with the Penkanüle first into the opening of the disposal container until the webs and recesses of the Penkanüle engage in the corresponding elements of the opening. In this position then with the unscrewed from an internal thread on an external thread of the injection pen Penkanüle unscrewed from the injection pen and engaged behind by a stop. Thereafter, the injection pen is led away from the opening of the disposal container. Ideally, the penkanula with its webs and recesses should then detach from the corresponding elements of the opening and fall into the disposal container in which it is now safely stored.
  • the invention is based on the object to provide a device according to the preamble of claim 1, with which the safe disposal of Penkanüle in a disposal container or the safe storage of Penkanüle simplified in a storage container and a risk of infection and injury for the person performing the disposal is significantly minimized. Furthermore, the device should be independent of the geometry of the Injetationspens in their release.
  • the latching means of the device according to the invention engage in the counter-latching means of the release device of the disposal means.
  • Storage container After removal of the Injetationspen solve in a disposal container, the locking means of the device according to the invention of the counter-locking means of the release device of the disposal container and the device now falls freely into the same. Neither on the device itself nor at the opening elements are arranged which a snagging or tilting the Cause device in the opening and could interfere with unhindered falling into the disposal container.
  • Another advantage of this invention is that in particular diabetics who are dependent on regular insulin injections by means of injection pens and often already have a significant visual impairment due to their disease, receive a haptic and acoustic feedback by the latching and counter-latching means when the inventive device in the release device the disposal or storage container is locked.
  • the invention is the release mechanism independent of the geometry of the injection pen.
  • the locking means it has proved to be advantageous to form the locking means as simple webs.
  • the counter-locking means can be provided in a simple manner, for example. As simple bulges available.
  • the locking means on the rear stops which are adapted to be engaged behind by rear stops of the release device of a storage or disposal container for the device.
  • the locking means also have lateral stops which are adapted to be engaged behind by lateral stops of the counter-locking means of the release device of a storage or disposal container for the device. This also ensures that the latching and counter-locking means can not be solved unnoticed by an unintentional rotation of the device according to the invention within the release device from each other.
  • the locking means of the inventive device are designed as webs, it is also advantageous to form the counter-locking means as bulges in the release device. As a result, a secure fixation of the locking and Schwarzratstoff is guaranteed against each other.
  • the locking means are distributed uniformly over the circumference of the body.
  • the counter-locking means are distributed uniformly over the circumference of the release device.
  • the locking means are arranged substantially in the central region of the base body.
  • the main body of the device according to the invention is designed as a hollow body, which can be connected in a simple manner with the Injetechnischspen.
  • the hollow cylindrical base body on coupling means, which are designed to cooperate with counter-coupling means of a Injetationspens for releasably disposing of it.
  • an internal thread in the hollow cylindrical body is provided as a coupling means, which is designed to cooperate with an external thread of a cannula receiving a device for the injection of liquids.
  • a coupling means at least one locking means in the hollow cylindrical body, which is designed to cooperate with at least one counter-locking means of a cannula receiving a device for the injection of liquids.
  • Such locking and counter-locking means ensure a secure fit and easy and quick attachment or detachment of the device from the device for the injection of liquids.
  • latching means at least one clip element, which is designed to cooperate with at least one counter-clip element of a cannula receptacle of a Injetechnischspens.
  • Such clip elements ensure a secure and easily releasable coupling connection, which can be produced in terms of process technology in a simple manner and inexpensively.
  • the invention also relates to a disposal or storage container for the device according to the invention described above.
  • a disposal or storage container is described in claim 15.
  • Advantageous embodiments can be found in the subclaims 16 to 18.
  • Figure 1 basic body of an embodiment of the device according to the invention in
  • FIG. 2 shows the main body according to FIG. 1 in a side view
  • Figure 3 the main body according to Figure 1 in a perspective
  • FIG. 4 the main body according to FIG. 1 in another perspective view
  • FIG. 5 shows another exemplary embodiment of the device according to the invention in the form of a pincushion in a side view
  • Figure 6 Injection pen with Penkanüle according to Figure 5, which for release in a
  • FIG. 7 is a plan view of the pincushion according to FIG. 6 from the disposal container;
  • FIG. 8 shows a detailed view of FIG. 7,
  • FIG. 9 shows a cross-sectional view of FIG. 8 along the sectional area A-A, wherein the injection pen is not shown, and FIG.
  • Figure 10 a plan view of a protective cap designed as a storage container.
  • the exemplary embodiment of a device according to the invention shown in FIGS. 1 to 4 is designed as a penkanula for an injection pen.
  • the Penkanüle consists essentially of a base body 2 and held therein secure against displacement, not shown cannula.
  • the main body 2 is formed in the illustrated embodiment as a hollow cylinder with a closing element 19 at its proximal end, which forms the conclusion of the closed end of the base body 2.
  • a reinforcing element 8 for the cannula (not shown) is arranged centrally in such a way that the central longitudinal axis 8 of the main body coincides with the central longitudinal axis of the reinforcing element.
  • the reinforcing element 8 serves to reinforce the cannula 1 in the region of the end element and to absorb forces acting on the cannula and to divert it into the base body 2.
  • locking means 3 or recesses and elevations are arranged on the lateral surface of the hollow cylindrical body 2 .
  • the depressions and elevations extend as parallel straight webs of the closed proximal to the open distal end of the base body 2.
  • the elevations extend beyond the base body 2 or are the recesses as recesses formed over the entire shell thickness of the base body 2.
  • the hollow cylindrical main body 2 has in its interior an internal thread 7, which is adapted to an external thread of an injection pen, so that a detachable connection between the penkanula and the injection pen can be produced by means of the two threads.
  • the detachable connection between the pincushion and the injection pen can also be effected by means of a connecting means 7a arranged on the pincushion, which cooperates with a connecting means (not shown here) arranged on the injection pen.
  • the connecting means 7a is designed as an undercut 9 pointing toward the elevations to the main body interior.
  • counter-locking means in this case acts not shown, arranged on the Injetationspen depression or clips or spring element. It can be provided for each undercut a separate recess. However, it is also possible, in particular if the undercuts all lie in one plane, to form a recess running around the surface of the injection pen as counter-locking means for the undercuts 9.
  • the corresponding outer and inner threads and possibly the other connecting means of Penkanüle and the Injetationspens are brought into engagement with each other and thus the Penkanüle releasably attached to the Injetationspen.
  • the cannula not shown, penetrates, with its end protruding into the hollow space of the main body 2 of the penkanule, a septum of a medicament cartridge arranged in the injection pen.
  • the medicament can subsequently be applied with the aid of the injection pen.
  • the drug comes out of the interior of the cartridge through the cannula of Penkangge.
  • the injection pen is inserted with the Penkangge forward in a trained as an opening release device 21 of a disposal container 20.
  • This opening is designed such that a part of the elevations and depressions of the cylindrical base body 2 of the penkanule engage in correspondingly corresponding elements within the opening, but with sufficient clearance to prevent the pinch tube from becoming stuck in the opening. If the elevations and depressions of the pincushion are in engagement with the corresponding elements of the opening, the pincushion can be detached therefrom by means of the two threads by turning the injection peg and releasing the connecting elements 7, 9 of the pincushion from the connecting elements of the injection pens.
  • FIG. 5 to 9 Another embodiment is shown in Figures 5 to 9.
  • the Penkanüle shown there can be releasably connected with its base body 2 in the same manner as in the embodiment of Figures 1 to 4 with the Injetationspen 10 by means of external and internal threads and / or connecting means.
  • the cannula 1 held in the central axis 4 of the base body 2 is shown.
  • Arranging the penkanula on the injection pen in this embodiment is analogous to the procedure as described for the embodiment of Figures 1 to 4.
  • latching means 3 designed as webs are arranged on the hollow cylindrical basic body 2 of the penkanule.
  • the latching means 3 extend on the lateral surface of the main body 2 substantially parallel to its central longitudinal axis 10 and in its longitudinal direction, wherein they begin at the level of one arranged at the closed proximal end of the base body 2 closing element 3 and approximately in the middle of the lateral surface of the main body. 2 end up.
  • the cannula 1 is held in a reinforcing element 8, which can also serve to hold a protective cap for the cannula 1.
  • FIGS. 6 to 9 of this embodiment show various views of the arranged on a Injetationspen 1 1 Penkanüle according to Figure 5, which is already introduced for releasing the Injetationspen 11 in an opening of a release device 21 of a disposal container 20.
  • FIG. 6 the pincushion according to the invention and the end of the injection pen 11, on which the pincushion is arranged, are shown in a sectional view in a plan view and the disposal container 20 for a better illustration of the release mechanism.
  • the Penkanüle is already introduced with its base 2 in the corresponding opening of the release device 21 of the disposal container 20 and is held by the locking means 3 of the needle holder and counter-locking means 23 of the release device 21 in this position.
  • the counter-locking means 23 have stops 24 which engage behind stops 4 of the locking means 3. The Penkanüle can not be easily pulled out of the opening of the release device 21 in this position.
  • the counter-means 23 with their stops 24 are flexible in the direction of the interior of the disposal container 20 is formed to allow insertion of the Penkanüle in the opening. Furthermore, these counter-means 23 with their stops 24, the opening of the release device 21 completely rotate or be formed only partially, so that the stops 4 of the locking means 3 are fully engaged behind. During insertion enter the counter-locking means 23 in the sliding direction and the locking means 3 slide on the counter-locking means 23 along. After the locking means 3 have passed the counter-locking means 23, these go back to their starting position and the stops 24 of the counter-locking means 23 engage behind the Stops 4 of the locking means 3. As a result, it is no longer possible to simply pull the Penkanüle out of the opening of the release device 21. This insertion is therefore an irreversible process.
  • the Penkanüle but also by means of an internal thread 7 with an external thread of the Injetationspens 11 cooperate. Because in this case the pincushion must be turned off from the injection pen 1 1, bulges 26 are arranged around the circumference of the opening of the release device 21, as can be seen in particular from FIGS. 7 and 8. Because the latching means 3 may not immediately engage with the bulges 26 upon insertion of the pincushion, the latching means 3 are chamfered over their longitudinal extent. The bevels thus formed allow a simplified positioning of the locking means 3 in the bulges 26. After the locking means 3 are engaged in the bulges 26, the penkanula can be easily turn away from the injection pen 11.
  • FIG. 10 shows a plan view of a storage container 20 designed as a protective cap for a penkanula. This also includes a release device 21 as shown in Figures 6 to 9. However, 21 bevels 27 are arranged on the latching means 23 of this release device, which facilitates insertion of the Penkanüle in the opening of the release device 21. To release the Penkanüle this is inserted into the opening of the release device 21.
  • the locking means 3 formed as webs of the penkan slide on slopes 27 of the release device 21 from until the penkanula is completely absorbed by the release device.
  • the pincushion is rotated until the locking means formed as webs 3 have moved over beads 28 so that they are fixed by the stops 25 in the bulges 26.
  • the ratstoff 3 are fixed in the bulges 26 prevent the beads 28 later unintentional slipping out of the locking means from the storage position. If the Penkanüle is connected by means of a thread with the Injetechnischspen 11, the Penkanüle is further turned off.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Working Measures On Existing Buildindgs (AREA)

Abstract

L'invention concerne un dispositif destiné à maintenir une canule et à être mis en place de manière amovible sur un stylo d'injection doté d'un corps principal (2), la canule étant agencée dans le corps principal de manière essentiellement non déplaçable le long de son axe central. L'invention prévoit que des moyens d'encliquetage (3) soient agencés sur la surface extérieure du corps principal, lesquels moyens sont formés de manière à être encliquetés par derrière par des moyens d'encliquetage antagoniste d'un dispositif de déblocage d'un réceptacle de stockage ou d'élimination pour le dispositif.
EP08758055A 2007-05-10 2008-05-13 Dispositif destiné à maintenir une canule et à être mis en place de manière amovible sur un stylo d'injection Withdrawn EP2144651A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007022404A DE102007022404A1 (de) 2007-05-10 2007-05-10 Vorrichtung zum Halten einer Kanüle und zur lösbaren Anordnung an einer Einrichtung zur Injektion von Flüssigkeiten
PCT/DE2008/000799 WO2008138319A1 (fr) 2007-05-10 2008-05-13 Dispositif destiné à maintenir une canule et à être mis en place de manière amovible sur un stylo d'injection

Publications (1)

Publication Number Publication Date
EP2144651A1 true EP2144651A1 (fr) 2010-01-20

Family

ID=39720194

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08758055A Withdrawn EP2144651A1 (fr) 2007-05-10 2008-05-13 Dispositif destiné à maintenir une canule et à être mis en place de manière amovible sur un stylo d'injection

Country Status (7)

Country Link
US (1) US8057444B2 (fr)
EP (1) EP2144651A1 (fr)
KR (1) KR20100016555A (fr)
CN (1) CN101765440B (fr)
BR (1) BRPI0811120A2 (fr)
DE (1) DE102007022404A1 (fr)
WO (1) WO2008138319A1 (fr)

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CA2639320C (fr) * 2007-09-07 2016-10-25 Becton, Dickinson And Company Aiguille pour stylo injecteur a l'epreuve de la faible application ou de l'application excessive d'un couple
US20110023281A1 (en) * 2009-04-30 2011-02-03 Stat Medical Devices, Inc. Pen injection device cap with integral pen needle quick release and/or removal system
WO2011068543A1 (fr) 2009-12-04 2011-06-09 Becton, Dickinson And Company Dispositif de retrait d'aiguille de stylo pour dispositif d'administration de médicament
US9216253B2 (en) * 2010-08-16 2015-12-22 Becton, Dickinson And Company Needle dispensing and storing apparatus for medicament delivery device
JP6073290B2 (ja) * 2011-04-28 2017-02-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ロックアウト要素を備えた投薬インターフェース
JP6654567B2 (ja) 2013-12-04 2020-02-26 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ペン針取付け機構
US11577030B2 (en) 2013-12-04 2023-02-14 Embecta Corp. Pen needle attachment mechanisms
EP3406283A1 (fr) 2017-05-26 2018-11-28 Becton, Dickinson and Company Aiguille de stylet
WO2019245757A1 (fr) 2018-06-22 2019-12-26 Becton, Dickinson And Company Aiguille de stylo

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JPH0336362Y2 (fr) * 1987-12-14 1991-08-01
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Also Published As

Publication number Publication date
US8057444B2 (en) 2011-11-15
DE102007022404A1 (de) 2008-11-13
US20100262088A1 (en) 2010-10-14
CN101765440A (zh) 2010-06-30
CN101765440B (zh) 2013-03-13
WO2008138319A1 (fr) 2008-11-20
BRPI0811120A2 (pt) 2014-12-23
KR20100016555A (ko) 2010-02-12

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