EP2135059A2 - Dispositif de mesure et procédé de détermination optique de la concentration de sucre dans le sang et/ou de lactate dans des systèmes biologiques - Google Patents

Dispositif de mesure et procédé de détermination optique de la concentration de sucre dans le sang et/ou de lactate dans des systèmes biologiques

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Publication number
EP2135059A2
EP2135059A2 EP08734378A EP08734378A EP2135059A2 EP 2135059 A2 EP2135059 A2 EP 2135059A2 EP 08734378 A EP08734378 A EP 08734378A EP 08734378 A EP08734378 A EP 08734378A EP 2135059 A2 EP2135059 A2 EP 2135059A2
Authority
EP
European Patent Office
Prior art keywords
volume
light
measuring
wavelength
radiation source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08734378A
Other languages
German (de)
English (en)
Inventor
Reinhard D. Beise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOCOMFORT DIAGNOSTICS VERWALTUNGS-GMBH
Original Assignee
Biocomfort Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocomfort Diagnostics GmbH filed Critical Biocomfort Diagnostics GmbH
Publication of EP2135059A2 publication Critical patent/EP2135059A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0256—Compact construction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G01J3/433—Modulation spectrometry; Derivative spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G01N2021/396—Type of laser source
    • G01N2021/399—Diode laser
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G01N2201/0612—Laser diodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
    • G01N2201/0691—Modulated (not pulsed supply)

Definitions

  • Measuring device and method for optical concentration determination of blood sugar and / or lactate in biological systems Measuring device and method for optical concentration determination of blood sugar and / or lactate in biological systems
  • the invention relates to a measuring device for the optical concentration determination of blood sugar and / or lactate in biological systems with at least one IR (infrared) - radiation source that emits IR light on a volume to be examined, with at least one measuring detector, the from receiving volume outgoing light, and with at least one reference detector, which is supplied to the volume to be examined radiated IR light before entering the volume, wherein the radiation source, the reference detector and the measuring detector connected via a lock-in and between the IR radiation source and the measuring detector is an optical measuring path with a first Meßweg malfunctionizing and formed between the IR radiation source and the reference detector, an optical reference path with a second, deviating from the first Meßweg futurites Meßweg futurites.
  • IR infrared
  • the invention also relates to a method for the optical concentration determination of blood sugar and / or lactate in biological systems, in which IR light along an optical measuring path irradiated to a volume to be examined and from the light emanating from the volume of a value relevant to the concentration using a Reference measurement of the IR light irradiated to the volume to be examined and a lock-in method is determined via an optical reference path, the optical reference path having a measurement path characteristic which deviates from the measurement path characteristic of the optical measurement path.
  • a relevant value for the concentration on the one hand, for example, a value proportional to the concentration or inversely proportional to the concentration can be determined. This can in particular serve the output of an analytical measured value.
  • a digital output with a lower information content for example for displaying a normal, a critical and a critical concentration value, or merely a binary signal, for example when a critical concentration value is exceeded, can be referred to as "relevant value”.
  • the term "relevant value” denotes a value which serves as a function of the concentration for detecting the information content desired with the present concentration determination.
  • WO 2005/112740 A2 and EP 0 670 143 B1 disclose comparatively simply constructed measuring devices which may possibly be operated on by a medical layman and, in particular, require no further aids, such as measuring strips or measuring chemicals.
  • WO 2005/112740 A2 dispenses with a reference measurement, so that it is not generic for this reason alone.
  • DE 100 20 615 C2 discloses a more complex measuring setup, which in particular requires a reference sample, ie a measuring chemical, and thus ensures that the optical paths between light source and measuring detector on the one hand and light source and reference detector on the other hand each have identical Meßweg malfunctionizinga, so that in particular sample and reference sample can be reversed.
  • a reference sample ie a measuring chemical
  • the invention proposes, on the one hand, a measuring device for optically determining the concentration of blood sugar and / or lactate in biological systems with at least one IR radiation source, which radiates IR light to a volume to be examined, with at least one measuring detector, which the light to be examined receives, and with at least one reference detector, which is supplied to the volume to be examined radiated IR light before entering the volume before, wherein the radiation source, the reference detector and the measuring detector via a lock-in with each other connected and between the IR radiation source and the measuring detector, an optical measuring path having a first Meßweg futurites and between the IR radiation source and the reference detector, an optical reference path with a second, deviating from the first Meßweg seeminglyizing Meßweg civilizing are formed and wherein the measuring device distinguished thereby t that the IR radiation source emits IR light in at least two discrete wavelengths or in at least two discrete wavelength bands on the volume to be examined.
  • the photons of the light which is fed to a detector are not available for further measurement.
  • the term "light” refers to a beam of photons from which a portion is or may be branched off for a reference measurement, so it is quite clear that photons used for the reference measurement are the volumes to be examined Nevertheless, relevant statements can be made about the nature of the IR light radiated onto the volume to be examined, since these photons originate from one and the same radiation source.
  • the invention also proposes a method for the optical concentration determination of blood sugar and / or lactate in biological systems, in which IR light is irradiated along an optical measuring path to a volume to be examined and from the light emanating from the volume for the concentration of relevant value taking advantage of a taking place via an optical reference path reference measurement of the radiated to the volume to be examined IR light and a lock-in method is determined, wherein the optical reference path has a measurement path characteristic which deviates from the measurement path characteristic of the optical measurement path and which is characterized in that at least one component from a previously determined or known spectrum is selected at least one peak of interest and the value relevant for the concentration is determined by at least two within this peak, discrete wavelengths or wavelength bands are determined.
  • a structurally simple embodiment can be realized by a beam splitter, which is arranged between the volume to be examined and the radiation source.
  • the beam splitter is preferably aligned such that a part of the light emitted by the radiation source is directed to the reference detector. In this way structurally very simple a reference measurement can be made.
  • the beam splitter is aligned such that at least a portion of the outgoing of the volume of light is directed to the measuring detector.
  • a configuration can for example be selected such that the volume to be examined, such as a finger, an earlobe or an arm, is arranged between the beam splitter and the measuring detector. This applies in particular to the case that an absorption measurement of the ER light is made.
  • a reflection measurement and / or a measurement of otherwise emitted light which by the stimulating IR light is stimulated to be measured, especially when this outgoing from the volume of light reaches the beam splitter and is guided by this starting to the measuring detector.
  • the measurement detector may, for example, be oriented linearly with respect to the volume-radiated HI light, which is advantageous in particular for absorption measurements.
  • the measurement detector may be particularly advantageous if the measurement detector is oriented at an angle with respect to the radiated IR radiation to the volume.
  • a beam splitter is not mandatory for reference measurement.
  • the reference detector may be directed, for example, to scattered light of the IR radiation source. Regardless of which light source is used, the generation of scattered light can hardly be avoided in light generation, since the resulting light is already partly refracted or otherwise distracted slightly in the radiation source itself. This applies in particular to laser light sources.
  • laser light sources require two opposing mirrors, between which the laser state can form. One of the mirrors is chosen to be semi-permeable, so that the laser light can be coupled out for further use by means of this mirror.
  • other coupling-out mechanisms are also conceivable, but they in turn generate scattered light which can be used for the reference measurement.
  • an excitation signal which is directed to a sample is modulated, it being assumed that a response of the sample induced by the modulated excitation is modulated accordingly, so that in the detector all measurement signals which do not have a corresponding modulation are correspondingly eliminated and measuring signals which have the same modulation can be amplified accordingly.
  • a modulation come, depending on the specific embodiment, both an amplitude and a frequency modulation in question.
  • lock-in methods are unusual in spectroscopic investigations, since such a modulation in the Fourier transform leads to disturbances. Even with chemical concentration determinations, such lock-in methods can not naturally be used.
  • the reference detector is also connected to the IR radiation source via the lock-in, so that disturbance effects, such as, for example, noise, can also be detected here.
  • an amplitude modulation can be carried out for the lock-in method, which can be embodied in particular binary, that is to say "light on” and "light off".
  • the amplitude modulation can be chosen to be much less aggressive and, for example, to a small amplitude fluctuations, for example in a window of less than 50% of the maximum strength, preferably less than 35% or less than 25%.
  • the amplitude modulation can also be designed as a sine wave, and thus less aggressive than the square wave of a binary signal.
  • a wavelength modulation can be made, wherein the bandwidth of the wavelength modulation is preferably less than 20 nm, preferably less than 18 or less than 15 nm, which can be ensured in particular by the lock-in or by the wavelength modulation a meaningful peak of the spectrum of the component whose concentration is to be determined is not left.
  • supplementary measures may have to be provided in order to be able to determine absolute values from a lock-in absolute value generated via wavelength modulation, since in this case the first derivative of a spectrum is usually first measured.
  • it is precisely the first derivative of a spectrum, in particular at suitable wavelengths, that can be at least as meaningful in terms of concentration as the spectrum itself.
  • laser diodes can be used as radiation sources.
  • laser diodes are unsuitable for spectroscopic investigations, which are usually used to determine concentration, since they do not have the necessary bandwidth for spectroscopic investigations.
  • such laser diodes have the advantage of a relatively good luminous efficacy, so that with relatively little equipment expense excellent radiation performance, especially in the IR range, can be achieved.
  • laser diodes can readily provide light for reference measurements, as has been generally explained in more detail above with reference to laser light sources.
  • the laser diodes may be advantageous to provide two or more laser diodes, which may be particularly advantageous for time reasons, since a modulation of a laser diode, in particular over a bandwidth of more than 20 nm addition, is relatively time-consuming, because The laser diode takes some time to stabilize. In addition, the expenditure on equipment increases disproportionately with such a large bandwidth.
  • the relevant peaks which are easily accessible with IR measurements, generally have a width of well over 200 nm.
  • a demand profile is created that is relatively inexpensive
  • the present invention is particularly suitable for embodiments in which the wavelength bands or the emission frequency of the IR radiation source is between 1000 nm and 2000 nm and / or between 2000 nm and 3000 nm.
  • the wavelength bands or the emission frequency of the IR radiation source is between 1000 nm and 2000 nm and / or between 2000 nm and 3000 nm.
  • water the major constituent of most biological systems, has a relatively low interaction with light.
  • components that can be found in such an environment better accessible to a measurement. It is understood that in other environments, where appropriate, other wavelength ranges can be used to advantage.
  • these two measuring points are controlled discretely, which can be realized on the one hand, for example, by two laser diodes or on the other hand by a laser diode whose wavelength is changed according to leaps and discretely.
  • laser diodes can be stabilized relatively accurately to a few nanometers, this is relatively time-consuming, so that in particular two laser diodes are suitable for a discrete activation.
  • the accuracy of the selection of the measuring points is not necessarily limited to less than one nanometer. Rather, it may be sufficient if the measurement points lie within a wavelength bandwidth below 20 nm.
  • the frequency of the IR radiation source within the bandwidth of 20 nm in order to use this modulation for a lock-in method.
  • IR radiation sources it may be advantageous to continuously modulate the IR radiation sources in a range below 170 nm, preferably below 150 nm or below 120 nm, and from this modulation the shape of the selected peak determine from which of the value relevant for the concentration can be determined.
  • a wavelength-modulated or wavelength-modulated lock-in can be realized very well.
  • the use of multiple discrete wavelength bands, each of which is wavelength modulated, in an optical concentration determination of blood sugar and / or lactate in biological systems with at least one IR Radiation source, which radiates IR light to a volume to be examined, with at least one measuring detector, which receives light emitted from the volume to be examined, and with at least one reference detector, which the radiated to the volume to be examined IR light before entering the Volume is supplied, wherein the radiation source, the reference detector and the measuring detector connected via a lock-in, correspondingly advantageous.
  • IR light is irradiated to a volume to be examined and from the light emanating from the volume of a value relevant to the concentration using a reference measurement of the volume of irradiated IR light to be examined and a lock-in method are determined.
  • FIG. 1 shows a schematic structure of a first measuring arrangement
  • FIG. 2 shows a schematic structure of a second measuring arrangement
  • FIG. 3 shows a schematic structure of a third measuring arrangement
  • FIG. 4 shows a first possible process control
  • Figure 5 shows a second possible process control
  • FIG. 6 shows a third possible procedure.
  • the measuring arrangement according to FIG. 1 comprises a volume 1 in which the concentration of a component is to be determined.
  • IR light 2 is irradiated to the volume 1, which is generated by an IR laser diode 3, via an optical fiber 4 and a Kolima- torlinse 5 and a beam splitter 6 to the volume 1 is supplied.
  • the IR light 2 passes through the volume 1, the light 7 emanating from the volume 1 being bundled correspondingly into an optical fiber 9 via a collimator lens 8 and fed to a measuring detector 10.
  • a portion of the IR light from the IR laser diode 3 is fed via the beam splitter 6 as reference light 11 via a further collimator lens 12 and a further optical fiber 13 to a reference detector 14.
  • the light beam 2 and the detectors 10, 14 are metrologically connected to each other via a lock-in connection, not shown.
  • the arrangement of FIG. 3 utilizes scattered light or light 1 IA issuing through the rearward part of the IR laser diode 3 as the reference light.
  • this arrangement corresponds to the embodiment of Figure 1 and is designed for absorption measurement.
  • Figure 4 shows a section of a peak, which is selected from the known per se spectrum of the component whose concentration is to be determined.
  • the section comprises a wavelength range of approximately 200 nm.
  • a measurement is performed at two measurement points Pl and P2 whose wavelength separation is approximately 150 nm.
  • the measurement point Pl is selected to be within a range of the peak which is relatively independent of the concentration.
  • the measuring point P2 has been placed in a range which, on the other hand, is as significant as possible in terms of concentration, so that the difference between these two measuring points can be deduced from the concentration, the measuring point P1 serving as a reference, so that external influences, in particular the influences other components of the biological system can be excluded or minimized. Even with this measure, the measurement setup can be realized cumulatively or alternatively substantially simply.
  • the IR laser diode is relatively accurately tuned and preferably kept constant with fluctuations of less than 1 nm when the measuring points Pl and P2 are recorded
  • the laser diode in the method example according to Figure 5 with a bandwidth of approx. 15 nm modulated to produce a lock In-V experience implement.
  • the latter can be realized in the process control of Figure 4 via an amplitude modulation.
  • wavelength bandwidths B1 and B2 are used instead of measuring points.
  • the wavelength of the IR radiation source can also be modulated over a larger range, for example of approximately 150 nm, so that, in particular, the ranges B1 and B2, within which measurement results are recorded or used for concentration determination, are swept over can. Also from these measurements, which, however, will usually be very time consuming, relevant values can be determined via the concentration, whereby a lock-in can be realized by the appropriate modulation. However, it is also conceivable, despite a possible wavelength modulation with such a bandwidth to make an amplitude modulation and to use for the lock-in, while the modulation is used only for sweeping a corresponding wavelength band. In this context, it can be seen, in particular, that further wavelength bands, in particular also through the use of further IR radiation sources, can be tapped without further ado.
  • the measuring points or wavelengths P1 and P2 or wavelength bandwidths B1 and B2 are discretely spaced from one another. The same applies to the wavelength bandwidths Bl and B2, within which the measurement takes place in the embodiment according to FIG.
  • the characteristic of the path which the light passes from the IR laser diode 3 to the measuring detector 10 and which can be referred to as the optical measuring path 15 differs in all embodiments from the characteristic of the path which the light from the IR laser diode 3 to reference detector 14 passes through and which can be referred to as optical reference path 16, since the measuring path 15 with a medium, which is located in the volume 1, comes into contact, the optical reference path 16 are not affected becomes.

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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Abstract

L'invention vise à permettre à du personnel non spécialisé, de réaliser simplement, sur place, des mesures de la concentration de sucre dans le sang et/ou de lactate. A cet effet, l'invention concerne un dispositif de mesure pour la détermination optique de la concentration de sucre dans le sang et/ou de lactate dans des systèmes biologiques, comportant au moins une source de rayonnement IR irradiant de lumière IR un volume à examiner, et au moins un détecteur de mesure détectant la lumière provenant du volume à examiner. Selon l'invention, la lumière IR appliquée au volume à examiner est acheminée vers un détecteur de référence avant entrée dans le volume.
EP08734378A 2007-03-16 2008-03-16 Dispositif de mesure et procédé de détermination optique de la concentration de sucre dans le sang et/ou de lactate dans des systèmes biologiques Withdrawn EP2135059A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007013274 2007-03-16
DE102007032849A DE102007032849A1 (de) 2007-03-16 2007-07-12 Messeinrichtung und Verfahren zur optischen Konzentrationsbestimmung von Blutzucker und/oder Laktat in biologischen Systemen
PCT/DE2008/000438 WO2008113328A2 (fr) 2007-03-16 2008-03-16 Dispositif de mesure et procédé de détermination optique de la concentration de sucre dans le sang et/ou de lactate dans des systèmes biologiques

Publications (1)

Publication Number Publication Date
EP2135059A2 true EP2135059A2 (fr) 2009-12-23

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EP08734378A Withdrawn EP2135059A2 (fr) 2007-03-16 2008-03-16 Dispositif de mesure et procédé de détermination optique de la concentration de sucre dans le sang et/ou de lactate dans des systèmes biologiques

Country Status (4)

Country Link
US (1) US20100041969A1 (fr)
EP (1) EP2135059A2 (fr)
DE (2) DE102007032849A1 (fr)
WO (1) WO2008113328A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11229373B2 (en) * 2014-03-17 2022-01-25 Analog Devices, Inc. Low frequency noise improvement in plethysmography measurement systems
KR20180050948A (ko) 2016-11-07 2018-05-16 삼성전자주식회사 분광기 및 분광기의 동작 방법
US11903689B2 (en) 2019-12-20 2024-02-20 Know Labs, Inc. Non-invasive analyte sensor device
US10548503B2 (en) 2018-05-08 2020-02-04 Know Labs, Inc. Health related diagnostics employing spectroscopy in radio / microwave frequency band
EP3779408A1 (fr) * 2019-08-15 2021-02-17 optek-Danulat GmbH Dispositif de mesure et procédé de détermination d'une concentration de substance
US11063373B1 (en) 2019-12-20 2021-07-13 Know Labs, Inc. Non-invasive analyte sensor and system with decoupled transmit and receive antennas
US11031970B1 (en) * 2019-12-20 2021-06-08 Know Labs, Inc. Non-invasive analyte sensor and system with decoupled and inefficient transmit and receive antennas
US11234619B2 (en) 2019-12-20 2022-02-01 Know Labs, Inc. Non-invasive detection of an analyte using decoupled transmit and receive antennas
US11058317B1 (en) 2019-12-20 2021-07-13 Know Labs, Inc. Non-invasive detection of an analyte using decoupled and inefficient transmit and receive antennas
TW202143659A (zh) * 2019-12-20 2021-11-16 美商知道實驗室股份有限公司 具去耦發射與接收天線之非侵入式分析物感測器及系統
US11058331B1 (en) 2020-02-06 2021-07-13 Know Labs, Inc. Analyte sensor and system with multiple detector elements that can transmit or receive
US11330997B2 (en) 2020-02-06 2022-05-17 Know Labs, Inc. Detection of an analyte using different combinations of detector elements that can transmit or receive
US11193923B2 (en) 2020-02-06 2021-12-07 Know Labs, Inc. Detection of an analyte using multiple elements that can transmit or receive
US11832926B2 (en) 2020-02-20 2023-12-05 Know Labs, Inc. Non-invasive detection of an analyte and notification of results
US11389091B2 (en) 2020-09-09 2022-07-19 Know Labs, Inc. Methods for automated response to detection of an analyte using a non-invasive analyte sensor
US11510597B2 (en) 2020-09-09 2022-11-29 Know Labs, Inc. Non-invasive analyte sensor and automated response system
US11764488B2 (en) 2020-09-09 2023-09-19 Know Labs, Inc. Methods for determining variability of a state of a medium
US11689274B2 (en) 2020-09-09 2023-06-27 Know Labs, Inc. Systems for determining variability in a state of a medium
US11033208B1 (en) 2021-02-05 2021-06-15 Know Labs, Inc. Fixed operation time frequency sweeps for an analyte sensor
US11284819B1 (en) 2021-03-15 2022-03-29 Know Labs, Inc. Analyte database established using analyte data from non-invasive analyte sensors
US11284820B1 (en) 2021-03-15 2022-03-29 Know Labs, Inc. Analyte database established using analyte data from a non-invasive analyte sensor
US11234618B1 (en) 2021-03-15 2022-02-01 Know Labs, Inc. Analyte database established using analyte data from non-invasive analyte sensors
USD991063S1 (en) 2021-12-10 2023-07-04 Know Labs, Inc. Wearable non-invasive analyte sensor
US20230355140A1 (en) 2022-05-05 2023-11-09 Know Labs, Inc. High performance glucose sensor
US11802843B1 (en) 2022-07-15 2023-10-31 Know Labs, Inc. Systems and methods for analyte sensing with reduced signal inaccuracy
US11696698B1 (en) 2022-10-03 2023-07-11 Know Labs, Inc. Analyte sensors with position adjustable transmit and/or receive components
US11903701B1 (en) 2023-03-22 2024-02-20 Know Labs, Inc. Enhanced SPO2 measuring device

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2934190A1 (de) * 1979-08-23 1981-03-19 Müller, Gerhard, Prof. Dr.-Ing., 7080 Aalen Verfahren und vorrichtung zur molekuelspektroskopie, insbesondere zur bestimmung von stoffwechselprodukten
DE3510052A1 (de) * 1985-03-20 1986-09-25 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe Verfahren und prozessphotometer zur kontinuierlichen messung von konzentrationen
US4883963A (en) * 1986-04-28 1989-11-28 Bran+Luebbe Gmbh Optical analysis method and apparatus having programmable rapid random wavelength access
US4808824A (en) * 1987-09-17 1989-02-28 Sinnar Abbas M Compositional state detection system and method
US5209231A (en) * 1990-11-02 1993-05-11 University Of Connecticut Optical glucose sensor apparatus and method
DE4446723C2 (de) * 1994-06-29 1997-03-13 Hermann Prof Dr Harde Vorrichtung und Verfahren zur Messung der Konzentration eines Gases
DE4446390C1 (de) * 1994-12-23 1996-07-04 Siemens Ag Verfahren und Vorrichtung zur Messung der Konzentration eines in einer Probe enthaltenen Analyten
DE19525415C2 (de) * 1995-07-12 1997-11-27 Optikzentrum Nrw Gmbh Oz Verfahren und Vorrichtung zur Bestimmung der Wasserdampfkonzentration bzw. des Taupunktes
DE69626960T2 (de) * 1995-11-16 2003-11-06 Matsushita Electric Ind Co Ltd Verfahren und vorrichtung zur urinanalyse, verfahren zur messung optischer rotation und polarimeter
US6246893B1 (en) * 1997-06-12 2001-06-12 Tecmed Incorporated Method and device for glucose concentration measurement with special attention to blood glucose determinations
DE19826294C1 (de) * 1998-06-12 2000-02-10 Glukomeditech Ag Polarimetrisches Verfahren zur Bestimmung der (Haupt-)Schwingungsebene polarisierten Lichts auf etwa 0,1m DEG und miniaturisierbare Vorrichtung zu seiner Durchführung
DE19911265C2 (de) * 1999-03-13 2001-12-13 Glukomeditech Ag Vorrichtung zur Messung der Glukosekonzentration proteinhaltiger wässriger Lösungen insbesondere in interstitiellen Gewebsflüssigkeiten,vorzugsweise in implantierbarer mikro-opto-elektronischer Form
US6370407B1 (en) * 1999-07-27 2002-04-09 Tecmed, Incorporated System for improving the sensitivity and stability of optical polarimetric measurements
DE10020615C2 (de) * 2000-04-27 2002-02-28 Glukomeditech Ag Verfahren zur langzeitstabilen und gut reproduzierbaren spektrometrischen Messung der Konzentrationen der Bestandteile wässriger Lösungen sowie Vorrichtung zur Durchführung dieses Verfahrens
DE10030927C1 (de) * 2000-06-24 2002-05-23 Glukomeditech Ag Refraktometrisches Verfahren zur langzeitstabilen genauen Messung der Konzentrationen gelöster Stoffe sowie eine miniaturisierbare Vorrichtung zu seiner Durchführung
US7003337B2 (en) * 2002-04-26 2006-02-21 Vivascan Corporation Non-invasive substance concentration measurement using and optical bridge
EP1743576B1 (fr) * 2004-05-06 2018-01-24 Nippon Telegraph And Telephone Corporation Dispositif de mesure de concentration de composant et méthode de contrôle de dispositif de mesure de concentration de composant
GB0416732D0 (en) * 2004-07-27 2004-09-01 Precisense As A method and apparatus for measuring the phase shift induced in a light signal by a sample
US8498681B2 (en) * 2004-10-05 2013-07-30 Tomophase Corporation Cross-sectional mapping of spectral absorbance features
US20110184260A1 (en) * 2005-02-09 2011-07-28 Robinson M Ries Methods and Apparatuses for Noninvasive Determinations of Analytes
KR20080013919A (ko) * 2005-04-22 2008-02-13 더 제너럴 하스피탈 코포레이션 스펙트럼 도메인 편광 민감형 광간섭 단층촬영을 제공할 수있는 장치, 시스템 및 방법
US7729734B2 (en) * 2006-03-07 2010-06-01 Andreas Mandelis Non-invasive biothermophotonic sensor for blood glucose monitoring
US20120059232A1 (en) * 2008-12-24 2012-03-08 Glusense, Ltd. Implantable optical glucose sensing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2008113328A2 *

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WO2008113328A2 (fr) 2008-09-25

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