EP2119503A3 - Système microfluidique et procédé pour le tri d'amas de cellules et pour leur encapsulation en continu suite à leur tri - Google Patents
Système microfluidique et procédé pour le tri d'amas de cellules et pour leur encapsulation en continu suite à leur tri Download PDFInfo
- Publication number
- EP2119503A3 EP2119503A3 EP09290311A EP09290311A EP2119503A3 EP 2119503 A3 EP2119503 A3 EP 2119503A3 EP 09290311 A EP09290311 A EP 09290311A EP 09290311 A EP09290311 A EP 09290311A EP 2119503 A3 EP2119503 A3 EP 2119503A3
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- EP
- European Patent Office
- Prior art keywords
- clusters
- sorted
- cells
- sorting
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/414—Emulsifying characterised by the internal structure of the emulsion
- B01F23/4145—Emulsions of oils, e.g. fuel, and water
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2525—Stabilizing or preserving
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0802575A FR2931141B1 (fr) | 2008-05-13 | 2008-05-13 | Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2119503A2 EP2119503A2 (fr) | 2009-11-18 |
EP2119503A3 true EP2119503A3 (fr) | 2012-02-22 |
EP2119503B1 EP2119503B1 (fr) | 2015-04-01 |
Family
ID=40134794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09290311.1A Active EP2119503B1 (fr) | 2008-05-13 | 2009-04-29 | Système microfluidique et procédé pour le tri d'amas de cellules et pour leur encapsulation en continu suite à leur tri |
Country Status (4)
Country | Link |
---|---|
US (1) | US8263023B2 (fr) |
EP (1) | EP2119503B1 (fr) |
JP (1) | JP5414347B2 (fr) |
FR (1) | FR2931141B1 (fr) |
Families Citing this family (61)
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US9574832B2 (en) * | 2007-12-28 | 2017-02-21 | Intel Corporation | Enabling an aluminum heat exchanger with a working fluid |
FR2946895A1 (fr) * | 2009-06-19 | 2010-12-24 | Commissariat Energie Atomique | Systeme microfluidique et procede correspondant pour le transfert d'elements entre phases liquides et utilisation de ce systeme pour extraire ces elements |
JP5660396B2 (ja) | 2009-12-01 | 2015-01-28 | 日本電気株式会社 | データ伝送方法、データ受信方法、データ変調装置及びデータ復調装置 |
ITTO20100068U1 (it) * | 2010-04-20 | 2011-10-21 | Eltek Spa | Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici |
US9200938B2 (en) * | 2010-07-13 | 2015-12-01 | Toyota Institute of Technology | Microdroplet-producing apparatus |
EP2595754B1 (fr) | 2010-07-22 | 2018-04-04 | Gencell Biosystems Limited | Cellules de liquide composite |
US9133499B2 (en) | 2010-09-14 | 2015-09-15 | The Regents Of The University Of California | Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices |
US9090865B2 (en) | 2010-10-29 | 2015-07-28 | The Regents Of The University Of California | Systems and methods for particle classification and sorting |
US8870733B2 (en) * | 2010-11-19 | 2014-10-28 | Kensey Nash Corporation | Centrifuge |
CN102095284B (zh) * | 2011-01-30 | 2013-03-27 | 杭州沈氏换热器有限公司 | 一种换热器的微通道换热体的制造方法 |
US20120214224A1 (en) * | 2011-02-01 | 2012-08-23 | Chan Eugene Y | Flow based clinical analysis |
US20120202284A1 (en) * | 2011-02-07 | 2012-08-09 | Empire Technology Development Llc | Cell sorting apparatus and method |
US20120208255A1 (en) * | 2011-02-14 | 2012-08-16 | Geosynfuels, Llc | Apparatus and process for production of an encapsulated cell product |
CN102530833B (zh) * | 2011-12-02 | 2014-10-29 | 江苏大学 | 一种封闭式微流控通道刻蚀方法与自动刻蚀装置 |
WO2013116696A1 (fr) * | 2012-02-03 | 2013-08-08 | University Of Cincinnati | Procédés microfluidiques pour la séparation passive de cellules et de particules |
US10564147B2 (en) | 2012-05-25 | 2020-02-18 | The Regents Of The University Of California | Microfluidic systems for particle trapping and separation using cavity acoustic transducers |
US9222874B2 (en) * | 2012-06-27 | 2015-12-29 | The United States Of America As Represented By The Secretary Of The Army | Systems and methods for individually trapping particles from air and measuring the optical spectra or other properties of individual trapped particles |
JP6396911B2 (ja) | 2012-10-15 | 2018-09-26 | ナノセレクト バイオメディカル, インコーポレイテッド | 粒子を選別するためのシステム、装置、および、方法 |
CN104812492A (zh) | 2012-11-27 | 2015-07-29 | 基因细胞生物系统有限公司 | 处理液体样品 |
US11493428B2 (en) | 2013-03-15 | 2022-11-08 | Gpb Scientific, Inc. | On-chip microfluidic processing of particles |
US10324011B2 (en) | 2013-03-15 | 2019-06-18 | The Trustees Of Princeton University | Methods and devices for high throughput purification |
WO2014145237A1 (fr) * | 2013-03-15 | 2014-09-18 | Dialyflux, Llc | Surfaces permettant de manipuler un flux de particules |
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
US10384187B2 (en) | 2014-02-10 | 2019-08-20 | Gencell Biosystems Ltd | Composite liquid cell (CLC) mediated nucleic acid library preparation device, and methods for using the same |
US10502674B2 (en) | 2014-06-27 | 2019-12-10 | The Regents Of The University Of California | Apparatus and method for label-free analysis of rare cells from bodily fluids |
JP6832848B2 (ja) | 2014-10-20 | 2021-02-24 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | 組織試料処理システム及びそれに関連する方法 |
WO2016205742A1 (fr) * | 2015-06-17 | 2016-12-22 | The Regents Of The University Of California | Dispositif microfluidique à haut rendement pour le piégeage de cellules tumorales circulantes |
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KR101807256B1 (ko) * | 2016-01-26 | 2017-12-08 | 한양대학교 에리카산학협력단 | 입자 분리 장치 및 입자 분리 방법 |
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US20200353469A1 (en) * | 2016-04-20 | 2020-11-12 | University Of Virginia Patent Foundation | Systems for isolating and transplanting pancreatic islets |
US10717086B2 (en) | 2016-08-29 | 2020-07-21 | The Regents Of The University Of California | Integrated system for isolation and emulsification of particles and cells |
US10010883B2 (en) | 2016-09-20 | 2018-07-03 | International Business Machines Corporation | Deterministic lateral displacement arrays |
US11090653B2 (en) | 2016-10-11 | 2021-08-17 | The Regents Of The University Of California | Systems and methods to encapsulate and preserve organic matter for analysis |
FR3058328B1 (fr) * | 2016-11-07 | 2019-01-25 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Equipement de tri de particules presentes dans un echantillon fluidique |
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WO2018227210A1 (fr) * | 2017-06-09 | 2018-12-13 | The Regents Of The University Of California | Encapsulation à haut rendement dans des gouttelettes sur la base d'une commande de tourbillons hydrodynamiques |
US11517901B2 (en) | 2017-06-09 | 2022-12-06 | The Regents Of The University Of California | High-efficiency particle encapsulation in droplets with particle spacing and downstream droplet sorting |
EP3677337A4 (fr) * | 2017-08-30 | 2021-05-26 | Kyocera Corporation | Dispositif de séparation de particules et procédé de production de particules l'utilisant |
EP3675876A4 (fr) | 2017-09-01 | 2021-06-02 | GPB Scientific, Inc. | Procédés de préparation de cellules thérapeutiquement actives au moyen de la microfluidique |
WO2019075409A1 (fr) * | 2017-10-12 | 2019-04-18 | The Regents Of The University Of California | Isolement et identification sans étiquette microfluidique de cellules à l'aide d'une imagerie de durée de vie de fluorescence (flim) |
US11499127B2 (en) | 2017-10-20 | 2022-11-15 | The Regents Of The University Of California | Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks |
WO2019079787A1 (fr) | 2017-10-20 | 2019-04-25 | The Regents Of The University Of California | Systèmes microfluidiques et procédés pour la transfection cellulaire via des lipoflex |
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JP2019152477A (ja) * | 2018-03-01 | 2019-09-12 | 株式会社エンプラス | 液体取扱装置 |
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WO2020066306A1 (fr) * | 2018-09-28 | 2020-04-02 | 富士フイルム株式会社 | Structure cellulaire, procédé de production de structure cellulaire, procédé de culture cellulaire et voie de micro-écoulement |
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BE1026910B1 (nl) * | 2018-12-21 | 2020-07-22 | Pharmafluidics N V | Chemische reactoren |
CN109943475A (zh) * | 2019-04-12 | 2019-06-28 | 广西医科大学第一附属医院 | 一种微流控分选芯片及其分选系统 |
EP3962652A4 (fr) | 2019-04-30 | 2023-01-18 | Berkeley Lights, Inc. | Procédés d'encapsulation et d'analyse de cellules |
US10960394B2 (en) * | 2019-05-31 | 2021-03-30 | Amberstone Biosciences, Inc. | Microfluidic determination of low abundance events |
FR3117884B1 (fr) | 2020-12-21 | 2024-02-16 | Commissariat Energie Atomique | Système de tri par taille de particules expulsées par centrifugation et procédé de configuration d'un tel système |
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Also Published As
Publication number | Publication date |
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JP5414347B2 (ja) | 2014-02-12 |
FR2931141B1 (fr) | 2011-07-01 |
US20090286300A1 (en) | 2009-11-19 |
FR2931141A1 (fr) | 2009-11-20 |
JP2009273461A (ja) | 2009-11-26 |
US8263023B2 (en) | 2012-09-11 |
EP2119503A2 (fr) | 2009-11-18 |
EP2119503B1 (fr) | 2015-04-01 |
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