EP2068777A2 - Dispositifs pour réduire la dimension d'une ouverture de tissu interne - Google Patents

Dispositifs pour réduire la dimension d'une ouverture de tissu interne

Info

Publication number
EP2068777A2
EP2068777A2 EP07840828A EP07840828A EP2068777A2 EP 2068777 A2 EP2068777 A2 EP 2068777A2 EP 07840828 A EP07840828 A EP 07840828A EP 07840828 A EP07840828 A EP 07840828A EP 2068777 A2 EP2068777 A2 EP 2068777A2
Authority
EP
European Patent Office
Prior art keywords
recited
medical device
anchor
delivery
closure device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07840828A
Other languages
German (de)
English (en)
Other versions
EP2068777A4 (fr
Inventor
Richard J. Linder
Clark C. Davis
Scott D. Miles
Dewayne C. Fox
Daryl R. Edmiston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coherex Medical Inc
Original Assignee
Coherex Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/836,051 external-priority patent/US8840655B2/en
Priority claimed from US11/836,016 external-priority patent/US9220487B2/en
Application filed by Coherex Medical Inc filed Critical Coherex Medical Inc
Publication of EP2068777A2 publication Critical patent/EP2068777A2/fr
Publication of EP2068777A4 publication Critical patent/EP2068777A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A—HUMAN NECESSITIES
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    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
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    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
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    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
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    • A61B2017/00597—Implements comprising a membrane
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    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00601—Implements entirely comprised between the two sides of the opening
    • A—HUMAN NECESSITIES
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    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606—Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/0061—Implements located only on one side of the opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00619—Locking means for locking the implement in expanded state
    • A—HUMAN NECESSITIES
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    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00623—Introducing or retrieving devices therefor
    • A—HUMAN NECESSITIES
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    • A61B2017/00646—Type of implements
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    • A—HUMAN NECESSITIES
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    • A61B2017/0496—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials for tensioning sutures
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    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device

Definitions

  • Patent Application Serial No.11/836,051 filed August 8, 2007, titled SYSTEMS AND DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING (Attorney Docket No. 16348.27.4), U.S. Patent Application Serial No. 11/836,013, filed August 8, 2007, titled SYSTEMS AND DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING (Attorney Docket No. 16348.27.5), U.S. Patent Application Serial No.
  • the present invention relates generally to medical devices and methods of use for treating an internal tissue structure. More particularly, the present invention relates to medical devices, systems, and methods for reducing the size of an internal tissue opening. 2. The Relevant Technology
  • a PFO is an example of a cardiac birth defect that can be problematic and even result in death when combined with other factors such as blood clots or other congenital heart defects.
  • a PFO occurs when an opening between the upper two chambers of the heart fail to close after birth.
  • a blood clot in the left atrium can be passed through the aorta and travel to the brain or other organs, and cause embolization, stroke, or a heart attack.
  • a PFO can be treated by being closed by a surgical procedure.
  • other similar defects e.g., septal or otherwise
  • septal defects where some tissue needs to be closed in order to function properly can include the general categories of atrial-septal defects ("ASDs"), ventricular-septal defects (“VSD's”) and patent ductus arteriosus (“PDA”), and the like.
  • FIGS 1A-1C depict various views of a heart having a PFO.
  • the heart 10 is shown in a cross-section view in Figure IA.
  • the right atrium 30 receives systemic venous blood from the superior vena cava 15 and the inferior vena cava 25, and then delivers the blood via the tricuspid valve 35 to the right ventricle 60.
  • a septal defect which is shown as a PFO 50, is present between right atrium 30 and left atrium 40.
  • the PFO 50 is depicted as an open flap on the septum between the heart's right atrium 30 and left atrium 40.
  • the left atrium 40 receives oxygenated blood from the lungs via pulmonary artery 75, and then delivers the blood to the left ventricle 80 via the mitral valve 45.
  • some systemic venous blood can also pass from the right atrium 30 through the PFO 50 and mixes with the oxygenated blood in left atrium 40, and then is routed to the body from left ventricle 80 via aorta 85.
  • the interventricular septum 70 divides the right ventricle 60 and left ventricle 80.
  • the atrium is only partially partitioned into right and left chambers during normal fetal development, which results in a foramen ovale fluidly connecting the right and left atrial chambers.
  • the septum primum 52 incompletely fuses with the septum secundum 54 of the atrial wall, the result can be a tunnel 58 depicted as a PFO 50.
  • Figure 1C provides a view of the crescent-shaped, overhanging configuration of the septum secundum 54 from within the right atrium 30 in a heart 10 having a PFO 50.
  • the septum secundum 54 is defined by its inferior aspect 55, corresponding with the solid line in Figure 1C, and its superior aspect 53 represented by the phantom line, which is its attachment location to the septum primum 52.
  • the septum secundum 54 and septum primum 52 blend together at the ends of the septum secundum 54.
  • the anterior end 56a and posterior end 56p are referred to herein as "merger points" for the septum secundum 54 and septum primum 52.
  • the length of the overhang of the septum secundum 54 which is the distance between superior aspect 53 and inferior aspect 55, increases towards the center portion of the septum secundum as shown.
  • the tunnel 58 between the right atrium 30 and left atrium 40 is defined by portions of the septum primum 52 and septum secundum 54 between the merger points 56a and 56p which have failed to fuse.
  • the tunnel 58 is often at the apex of the septum secundum 54 as shown.
  • the portion of the septum secundum 54 to the left of tunnel 58 which is referred to herein as the posterior portion 57p of the septum secundum, is longer than the portion of the septum secundum 54 to the right of tunnel 58, which is referred to herein as the anterior portion 57a of the septum secundum 54.
  • the posterior portion 57p also typically has a more gradual taper than the anterior portion 57a as shown.
  • the anterior pocket 59a is the area defined by the overhang of the anterior portion 57a of the septum secundum 54 and the septum primum 52, and it extends from the anterior merger point 56a toward the tunnel 58.
  • the posterior pocket 59p is the area defined by the overhang of the posterior portion 57p of septum secundum 54 and the septum primum 52, and it extends from the posterior merger point 56p toward the tunnel 58.
  • Conventional treatments for PFO, and other related conditions have generally involved invasive surgery, which also presents a risks to a patient. Although there are some less invasive treatments for PFO, such treatments have been less efficient at closing the PFO opening than techniques involving invasive surgery. BRIEF SUMMARY OF THE INVENTION
  • the invention relates to a medical system, devices and methods of use for reducing the size of an internal tissue opening, such as a Patent Foramen Ovale ("PFO").
  • the medical system can include a closure device and an associated delivery device.
  • the medical system can be configured to enable a practitioner to selectively position and deploy the closure device in an internal tissue opening to approximate, or in other words bring together the tissue of the opening.
  • the closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor.
  • the multi-cellular body portion can be configured to enable the closure device to collapse into a relatively narrow non-deployed orientation and expand into a deployed or expanded orientation without plastic deformation or failure of the closure device.
  • the first and second anchors can be configured to engage at least a portion of a wall of the internal tissue opening and/or tissue, such as tunnel tissue, of the opening.
  • the closure device can be a non- tubular, substantially flat stent.
  • the closure device can include an ingrowth material to facilitate tissue growth.
  • the closure device can also include one or more indicators to facilitate the estimation of the position and/or orientation of the closure device with respect to the internal tissue opening.
  • the delivery device can include a delivery assembly, an actuating assembly, and a release assembly operatively associated with a handle body.
  • the delivery assembly facilitates selective delivery of the closure device from the delivery device, and is operatively associated with the actuating assembly and the release assembly.
  • the actuating assembly interacts with the handle body to selectively deploy the closure device from the delivery assembly.
  • the actuating assembly can be configured to deploy at least a portion of the closure device by a first movement and deploy a second portion of the closure device by a second movement.
  • the release assembly can be linked to the handle body to facilitate detachment of the closure device from the delivery device.
  • the closure device is linked to the delivery device by one or more tethers and one or more wires, the tethers being coupled to the handle body and the wires being coupled to a biasing member of the release assembly.
  • the tethers can be configured to receive a portion of the closure device therein to facilitate securement of the closure device to the delivery device.
  • the wires can be detachably coupled to the closure device to enable selective detachment of the closure device from the delivery device by movement of the biasing member.
  • Figures IA- 1C illustrate exemplary views of a heart having a Patent Foramen Ovale
  • Figure 2 illustrates a perspective view of an embodiment of a medical system according to the present invention
  • Figure 3A illustrates an embodiment of a closure device according to the present invention
  • Figure 3B illustrates an embodiment of a closure device in a non-deployed orientation according to the present invention
  • Figure 3C illustrates a cut-out view of a portion of a closure device according to the present invention
  • Figure 4 illustrates an embodiment of a delivery device according to the present invention
  • Figures 5A-5C illustrate cross-sectional views of a delivery device according to the present invention
  • Figure 6 illustrates an exploded view of a delivery device according to the present invention
  • Figure 7 illustrates an embodiment of a coupling system according to the present invention
  • Figure 8A illustrates an embodiment of a closure device being partially deployed in an internal tissue opening
  • Figure 8B illustrates an embodiment of a delivery device in an orientation corresponding to the partially deployed closure device of Figure 8A;
  • Figure 9 illustrates an embodiment of a partially deployed closure device according to the present invention.
  • Figure 1OA illustrates an embodiment of a closure device positioned in an internal tissue opening
  • Figure 1OB illustrates an embodiment of a delivery device in an orientation corresponding to the deployed and detached closure device of Figure 1OA;
  • Figure 1 IA illustrates an embodiment of a closure device having an ingrowth material according to the present invention
  • Figure 1 IB illustrates a side view of the closure device of Figure 1 IA.
  • the present invention extends to medical systems, methods, and apparatus for reducing the size of an internal tissue opening.
  • the devices disclosed herein can be used to treat a variety of internal tissue openings, such as a left atrial appendage, paravalvular leaks, PDA's, and VSD's, for example.
  • internal tissue openings such as a left atrial appendage, paravalvular leaks, PDA's, and VSD's, for example.
  • PFO Patent Foramen Ovale
  • references to PFO openings are not limiting of the invention.
  • Figure 2 is a perspective view of a medical system 100 configured to facilitate closure of an internal tissue opening according to one embodiment of the present invention.
  • the medical system 100 comprises a closure device 200 adapted to reduce the size of the internal tissue opening, and a delivery device 300 adapted to facilitate placement and deployment of the closure device 200 with respect to the internal tissue opening.
  • the medical system 100 of the present invention can provide benefits.
  • the medical system 100 can be configured to be used with different sizes, shapes and types of internal tissue openings.
  • the medical system 100 can provide various safety measures to increase the safety and effectiveness of positioning the closure device 200.
  • the medical system 100 can be configured to provide distributed lateral force to tissue of the internal tissue opening.
  • delivery device 300 comprises a handle body 302, an actuating assembly 320 operatively associated with handle body 302, a release assembly 340 operatively associated with the handle body 302 and a delivery assembly 360 operatively associated with the actuating assembly 320, the release assembly 340 and the handle body 302.
  • Handle body 302 can be configured to provide a gripping surface for a user.
  • Handle body 302 can be used to position closure device 200, as well as facilitate deployment of the closure device 200 from the delivery assembly 360.
  • Actuating assembly 320 can be moved with respect to handle body 302 to selectively deploy portions of the closure device 200 from the delivery assembly 360, as will be discussed more fully herein below.
  • Release assembly 340 can be operatively associated with the handle body 302 to enable selective detachment of closure device 200 from the delivery assembly 360.
  • Delivery assembly 360 can house closure device 200 in a non-deployed or constrained orientation, such as illustrated in Figure 3B for example, and facilitate deployment of closure device 200.
  • Delivery assembly 360 can include one or more tethers 364 linked to the closure device 200 to facilitate selective detachment of the closure device 200 from the delivery device 300.
  • the closure device 200 is illustrated in a fully deployed, expanded, relaxed or non-constrained orientation.
  • the closure device 200 can be configured to reduce the size of an internal tissue opening so as to close the internal tissue opening.
  • the closure device 200 can reduce the size of an internal tissue opening by approximating, or in other words bringing together tissue of the internal tissue opening, such as tunnel tissue in a PFO.
  • the closure device 200 can approximate tissue by applying lateral force to tissue of the internal tissue opening, as will be discussed more fully herein after.
  • the closure device 200 can be configured to enable a user to estimate the position and/or orientation of the closure device 200 with respect to an internal tissue opening, during and after positioning of the closure device 200 in the internal tissue opening.
  • the closure device 200 can be a non-tubular stent .
  • the closure device 200 can be configured to assume a substantially flat configuration, or in other words be configured to be substantially planar, such as illustrated in Figures 3 A and HB for example.
  • the closure device 200 can be configured to resist movement out of plane, such as plane 260 of Figure HB.
  • the closure device 200 may bend out of plane when positioned in a tissue opening.
  • the closure device 200 has many advantages.
  • the closure device 200 can be configured to be reliable and compliant.
  • the configuration of the closure device 200 can enable the closure device 200 to be movable between a non-deployed orientation and a deployed orientation without causing failure or plastic deformation of the closure device 200.
  • the closure device 200 can be used to close various types, shapes and sizes of internal tissue openings.
  • the closure device 200 can accommodate for a range of PFO tunnel lengths, for example.
  • the closure device 200 can be partially or fully deployed from or received back into the delivery device 300.
  • Closure device 200 can be configured to substantially conform to the size and shape of a tissue opening.
  • the undulations on the distal and proximal anchors can enable the anchors to substantially, or to a certain degree, conform to the anatomy of a tissue opening.
  • the closure device 200 can have a substantially flat aspect having a length and height greater than its depth or depth thickness.
  • the closure device 200 has an overall length of 22mm, a height of 7.5mm and a depth thickness of 0.4mm.
  • the distance between the opposing ends of the proximal anchor 218 can be about 22mm
  • the distance between the most proximal attachment member 240 of the body portion 202 and the most distal indicator 220 of the body portion 202 can be about 7.5mm
  • the depth thickness, designated as DT in Figure 1 IB, of the closure device 200 can be about 0.4mm.
  • the majority of segments comprising the closure device 200 can have a thickness or width that is substantially less than the depth thickness of the segments.
  • the closure device 200 can resist out of plane movement due to the size and configuration of the segments.
  • the closure device 200 can be configured to assume a substantially flat configuration in a first plane.
  • the configuration of the segments for example the segments having a certain depth thickness, can facilitate the closure device 200 resisting movement out of the first plane in a manner similar to an I beam resisting bending in the direction of the web of the beam.
  • the first plane can be plane 260 as illustrated in Figure 1 IB.
  • the closure device 200 can have a unitary construction.
  • the closure device 200 can be cut from a single piece of material, such as cut by a laser, thereby removing the need to assemble or join different segments together.
  • a unitary construction can provide advantages, such as ease of manufacturing and reliability. For example, assembly is not required for a closure device having a unitary construction. Also, a closure device having a unitary construction may not include distinct elements or segments which require joining by joints, thereby reducing a likelihood of failure.
  • the closure device 200 can be made from a super-elastic material, such as a super-elastic metal or a super-elastic polymer.
  • the closure device 200 can be made from NiTiNoI, stainless steel alloys, magnesium alloys, and polymers including bioresorbable polymers.
  • the closure device can be formed by utilizing a pressurized stream of water, such as a water jet, to remove material from a piece of material to form the closure device.
  • a pressurized stream of water such as a water jet
  • the closure device can be formed by utilizing one or more of the following: die casting, chemical etching, photolithography, electrical discharge machining, or other manufacturing techniques. It is contemplated that the closure device can be formed through use of a mill or some other type of device adapted to remove material to form a desired shape.
  • the closure device 200 can comprise multiple segments joined together by a known joining process, such as by an adhesive, by interference fits, crimping, by fasteners, or a weld, or some combination thereof.
  • the closure device can include multiple segments joined together by various welds to form a closure device according to the present invention.
  • the segments can be joined together by a plurality of means, such as by the combination of welding, fasteners, and/or adhesives.
  • the segments can be a wire or multiple joined or rolled wires crimped together or joined by a joining process to form the closure device 200.
  • the closure device 200 includes a body portion 202, a first anchor 204 operatively associated with the body portion 202 and a second anchor 206 operatively associated with the body portion 202.
  • the body portion 202 can be configured to facilitate application of lateral force against tissue of an internal tissue opening.
  • the body portion 202 can be configured to enable the closure device 200 be movable between a non-deployed and deployed orientation.
  • the closure device 200 can be configured to be self-expanding from the constrained or non-deployed orientation, as illustrated in Figure 3B for example, to the relaxed orientation, as illustrated in Figure 3A.
  • the closure device 200 can have a preferential orientation, such that movement of the closure device 200 from a first orientation to a second orientation can create internal stresses in the closure device 200. These internal stresses can serve to bias the closure device 200 to the first orientation.
  • the closure device 200 can have a preferential orientation of the relaxed or fully deployed orientation as illustrated in Figure 3A.
  • movement of the closure device 200 to a constrained orientation such as illustrated in Figure 3B for example, can create internal stresses in the closure device 200, thereby creating in the closure device 200 a bias to return to the relaxed orientation.
  • body portion 202 includes one or more cells 208 defined by a plurality of segments 210.
  • the body portion 202 can include one or more apertures.
  • an aperture is defined by the cell 208, or in other words by the plurality of segments 210.
  • segment 210 can be a strut or a body support segment.
  • Cells 208 can be distinct, or can be at least partially defined by a common segment.
  • cell 208A as the distal most cell
  • cell 208C as the proximal most cell of body portion 202
  • cell 208B is partially defined by a segment 210C which also defines a portion of cell 208A.
  • cell 208B is partially defined by a segment 210G which also partially defines cell 208C.
  • cell 208D shares a segment 210D with cell 208A and shares a segment 210H with cell 208C.
  • Segments 210 can be shaped and configured to have a substantially uniform stress at any given point along a certain length, when the segment 210 is deflected.
  • segment 210A can include a first portion 230 having a width or thickness greater than a second portion 232, wherein the width or thickness decreases from the first portion 230 to the second portion 232, or in other words is tapered, in a manner which provides for substantially uniform stress levels along the certain length.
  • segments can have a substantially constant width along their length.
  • Figure 3C is a cut-out view of a portion of the closure device 200, including the first portion 230 and the second portion 232 of segment 210A.
  • the width or thickness of the segment 210A varies along the portion of the segment 210A from the location where segment 210A extends from the portion 254 which joins segment 210A to segment 210C to the intermediate portion 234.
  • the segments 210 are deflected, with the highest levels of stress in the segment 210 being concentrated at the joining portion 254 and decreasing towards the intermediate portion 234.
  • the segments 210 can be configured in a manner so as to have a substantially equal stress level along the length of the segment 210 between the joining portion 254 and the intermediate portion 234.
  • the uniform stress level can be accomplished by having the width of the segment 210 vary from the first portion 230 to the second portion 232 in a calculated manner.
  • the width of the first portion 230 of the segment can be about .lmm and the taper to a width of about .05mm at the second portion 232 of the segment.
  • the uniform stress level can be accomplished by utilizing a gradient of material having varying properties.
  • the segment 210 can have varying widths along its length and comprise a gradient of material sufficient to achieve a substantially uniform stress level between the first portion 230 and the second portion 232 of the segment.
  • the first portion is adjacent the joining portion 254 and the second portion is adjacent the intermediate portion 234.
  • the joints of the interconnecting segments can include a biasing member, such as a spring, thereby enabling the segments to move relative to each other to collapse or expand the closure device 200.
  • the biasing member of the joint can cause the segments to have a preferential orientation with respect to each other.
  • segments 210 can also be configured to have a rectangular cross-section. In other embodiments, segments 210 can have an oval shaped cross section. In yet another embodiment, sections 210 can have a round or rounded cross section.
  • the ratio, or aspect ratio, of the thickness or width to the depth thickness of the first and second portions 230, 232 can range between at least about 1 :2 to about 1 :20. In one embodiment, the aspect ratio of the width to the depth thickness of the first portion 230 can be at least 1 :2 and the ratio of the width to the depth thickness of the second portion 232 can be at least 1 :4.
  • the aspect ratio of the first portion 230 can be about 1 :4 and the aspect ratio of the second portion 232 can be about 1 :8. In this manner, the closure device 200 can substantially resist out of plane movement, while allowing in-plane movement during reorientation of various portions of the closure device 200.
  • Segments 210 can be configured to be compliant. Compliancy of segments 210 can enable cells 208, and thus the body portion 202, to be oriented in various orientations. For example, body portion 202 can be oriented, or in other words moved, between a non-deployed orientation, such as illustrated in Figure 3B, and a fully deployed orientation, such as illustrated in Figure 3A. The compliancy of segments 210 can facilitate the accommodation by the closure device 200 of a variety of types, shapes and sizes of internal tissue openings. For example, the size and configuration of the first and second anchors 204, 206 and the body portion 202 can enable the closure device 200 to accommodate varying sizes, shapes and types of internal tissue openings.
  • the first anchor 204 can engage wall tissue of an internal tissue opening and the second anchor 206 can engage only the tunnel tissue of the internal tissue opening to approximate tissue.
  • the second anchor 206 can engage the tunnel tissue and an opposing wall of the internal tissue opening to approximate tissue.
  • Segments 210 can include an intermediate portion 234 configured to facilitate securement of ingrowth materials to the closure device 200, or can be used as an indicator 220 to facilitate estimation of the position of the closure device 200 with respect to an internal tissue opening. Furthermore, intermediate portion 234 can be configured to facilitate measuring of a characteristic of an internal tissue opening. In one embodiment, intermediate portion 234 can include one or more apertures. The apertures can be configured to receive a securing element, such as a thread, therethrough to facilitate securing an ingrowth material to the closure device 200. Intermediate portion 234 can be configured to be stiffer or more rigid than first portion 230, second portion 232, or both. A stiffer intermediate portion 234 can increase the reliability of segments 210.
  • the intermediate portion 234 can include an indicator 220, such as a dense metallic rivet or concentration of dense material, for use in estimating the orientation and/or position of the closure device 200.
  • an indicator 220 such as a dense metallic rivet or concentration of dense material
  • Understanding of the orientation and/or position of the closure device 200 can facilitate estimating a physical characteristic of an internal tissue opening and/or the relative position of the closure device 200 with respect to the internal tissue opening. For example, if the distance between the indicators 220 is known, a practitioner can estimate a physical characteristic, such as the opening or tunnel width, by determining the new distance between the indicators 220 when the closure device 200 is positioned in the tissue opening.
  • indicators 220 can be positioned on the first and second anchors 04, 206. The indicators 220 can be configured and arranged on the closure device 200 such that when the first anchor 204 is deployed the indicators 220 are substantially aligned. In this manner, a practitioner can estimate whether the first anchor 204 has fully deployed.
  • closure device 200 it may be difficult to view the closure device 200 in the event the closure device 200 is at a skewed angle with respect to the viewing plane, such as a fluoroscope.
  • a fluoroscope When the closure device 200 is skewed in this manner, it can be difficult to determine accurately the distance of interest.
  • a user can use the known distances to calculate the distances of interest by using geometry.
  • segments 210 along a similar or common lateral plane can have substantially equal lengths. Substantially equal lengths of segments 210 in this manner can enable body portion 202 to be moved between the non-deployed and deployed orientation without failure of the segments 210.
  • segments 21 OA and 21 OB have substantially the same length
  • segments 210E, 210C, 210D, and 210K have substantially the same length
  • segments 210F, 210G, 210H and 210L have substantially the same length
  • segments 2101 and 210J have substantially the same length.
  • body portion 202 can be collapsed or oriented into the non-deployed orientation, as illustrated in Figure 3B, without causing damage to the body portion 202 of closure device.
  • the closure device 200 can be configured to have a preferential orientation of the fully deployed orientation as illustrated in Figure 3A. As the closure device 200 is deployed from the delivery device 300, the configuration of closure device 200 can cause the closure device 200 to preferentially move toward the fully deployed orientation. Thus, as the closure device 200 is deployed in an internal tissue opening, the preferential orientation of the closure device 200 can cause the closure device 200 to apply lateral force to the tissue of the internal tissue opening. In other words, the body portion 202, first anchor 204 and the second anchor 206 are deflected by an applied force in order to reorient the closure device 200 from the fully deployed orientation to a non-deployed orientation, for example.
  • the closure device 200 because of the deflection of the body portion 202, first anchor 204 and the second anchor 206, will have tendency to return to the fully deployed orientation.
  • the deflected body portion 202, first anchor 204 and the second anchor 206 can have a tendency to apply a lateral force to tissue of the opening as the closure device 200 attempts to return to the fully deployed orientation.
  • Body portion 202 can be operatively associated with the first anchor 204 and the second anchor 206.
  • First and second anchors 204, 206 can be configured to move between a deployed and non-deployed orientation.
  • First and second anchors 204, 206 can be configured to apply lateral force to tissue of an internal tissue opening, and to engage and/or contact a portion of wall tissue and/or tunnel tissue of an internal tissue opening.
  • the first anchor 204 can be a left atrial anchor
  • the second anchor 206 can be a right atrial anchor.
  • the first anchor 204 can include a first anchor segment 212 and an opposing second anchor segment 214.
  • the second anchor 206 can include a first anchor member 216 and an opposing second anchor member 218.
  • the first anchor segment 212 can be configured to move relative to the second anchor segment 214.
  • the first anchor member 216 can be configured to move relative to the second anchor member 218.
  • the closure device 200 can accommodate for a variety of types, shapes and sizes of internal tissue openings.
  • the first anchor segment 212 and the second anchor segment 214 can be configured to be substantially similar in size, shape and configuration. As such, reference to the configuration and/or function of one of the first or second anchor segments can apply to the other anchor segment.
  • the first anchor 204 and/or the second anchor 206 can include one or more undulations.
  • the undulations can facilitate reorienting or movement of the anchors with respect to the body portion 202, for example, from a deployed to a non-deployed configuration. Furthermore, the undulations can facilitate the anchor substantially conforming to the anatomy of the tissue opening.
  • the first anchor segment 212 can include a distal end 224 and a proximal end 226.
  • the first anchor segment 212 can be defined by various segments and can include reinforced segments 228 and one or more engaging members 222.
  • the first anchor segment 212 is at least partially defined by segment 210K of cell 208D.
  • the engaging members 222 can be microposts or tines configured to contact and/or engage tissue.
  • the engaging members 222 can include a sharp tip or can be blunt.
  • the engaging members 222 can be configured to provide a degree of surface texture in order to increase engagement of the first anchor 204 with tissue.
  • the first anchor segment 212 can be configured to be moved between a non- deployed orientation, as illustrated in Figure 3B, and a fully deployed orientation, as illustrated in Figure 3A.
  • the first anchor segment 212 can be configured such that the distance from the proximal end 226 to the distal end 224 of the segment which includes the engaging members 222 is substantially equal to the distance from the proximal end 226 to the distal end 224 of the segment which includes the reinforced segments 228 and segment 210K.
  • the second anchor segment 214 can be configured similar to the first anchor segment 212.
  • First anchor segment 212 can be configured to define a closed periphery.
  • first anchor segment 212 can include the reinforced segment 228 extending from the body portion 202 to the segment having the engaging members 222 which is connected to segments 210K, 210L to define a closed periphery with segment 210K.
  • two reinforced segments 228 can extend from the joining portion 254 of the body portion 202 and join together near the distal end 224 of the first anchor 204.
  • anchors of the present invention are reinforced to provide greater rigidity and strength to facilitate stabilization and maintenance of the closure device 200 within a tissue structure.
  • First anchor member 216 can include a distal end 236 and a proximal end 238.
  • the first anchor member 216 can be defined by various segments and can include one or more engaging members 222.
  • the first anchor member 216 is at least partially defined by segment 210L of cell 208D.
  • the engaging members 222 can be microposts or tines configured to contact and/or engage tissue.
  • the engaging members 222 can include a sharp tip or can be blunt.
  • the engaging members 222 can be configured to provide a degree of surface texture to increase engagement of the second anchor 206 with tissue.
  • the engaging members 222 can vary in size and shape, and can be positioned at various locations on the closure device 200.
  • one or more engaging members can extend out of plane of the closure device so as to contact tissue which is perpendicular, for example, to the substantially flat plane, such as plane 260 of Figure 1 IB, of the closure device 200.
  • the first anchor member 216 can be configured to be moved between a non- deployed orientation, as illustrated in Figure 3B, and a fully deployed orientation, as illustrated in Figure 3A.
  • the first anchor member 216 can be configured such that the distance from the proximal end 238 to the distal end 236 of the segment which includes the engaging members 222 is substantially equal to the distance from the proximal end 238 to the distal end 236 of the segment which includes segment 210L. In this manner, first anchor member 216 can be detachably coupled to the delivery device 300 when in a non-deployed orientation inside the delivery device 300 as illustrated in Figure 3B.
  • the second anchor member 218 can be configured similar to the first anchor member 216.
  • the first anchor segment 212 can also include a first portion 256 and a second portion 258 configured to facilitate engagement of the internal tissue opening.
  • first anchor segment 212 can be configured to include one or more undulations causing the first portion 256 to be positioned in close proximity with second portion 258. In this manner, as tissue is positioned between the first and second portions 256, 258, the configuration of the first anchor segment 212 can engage, or to some degree, pinch the tissue therebetween to facilitate maintenance of the position of the closure device 200 with respect to the tissue opening.
  • the closure device 200 can also include attachment members 240 for use in detachably linking the closure device 200 to the delivery device 300, as will be discussed more fully herein after.
  • the attachment members 240 can include an aperture 242 for use in facilitating the linking of the closure device 200 to the delivery device 300.
  • Figure 3B illustrates the closure device 200 in a non-deployed or constrained orientation.
  • the configuration of the body portion 202, and the first and second anchors 204, 206 enables the closure device 200 be reoriented from the fully deployed and preferential orientation, as illustrated in Figure 3A, to the non-deployed or collapsed orientation as illustrated.
  • the first anchor 204 extends distally and the second anchor 206 extends proximally, with the attachment members 240 being the proximal most portions of the second anchor 206 and the body portion 202.
  • the closure device 200 is positioned inside of a delivery portion 366 of the delivery device 300.
  • the configuration of the closure device 200 can cause portions of the closure device to apply force to the wall of the delivery portion 366 due to the preferential orientation of the closure device 200.
  • the closure device 200 is configured to be received into and deployable from the delivery portion 366.
  • Figure 4 illustrates one embodiment of the delivery device 300.
  • the delivery assembly 360 includes a catheter 362 having a delivery portion 366, and a plurality of tethers 364 at least partially housed by the catheter 362.
  • the tethers 364 can be configured to facilitate selective detachment of the closure device 200 from the delivery device 300.
  • the delivery portion 366 can be configured to receive the closure device 200 therein.
  • the catheter 362 can be coupled to the actuating assembly 320, such that movement of the actuating assembly 320 can cause movement of the catheter 362.
  • the actuating assembly 320 includes a first member 322 operatively associated with the handle body 302, a second member 324 operatively associated with the first member 322 and the handle body 302, and a knob 338 linked to the first member 322.
  • the actuating assembly 320 can be utilized by a user to selectively deploy the closure device 200 from the catheter 362.
  • the handle body 302 can include indicia 304 to enable a user to estimate the degree of deployment of the closure device 200 from the delivery device 300, as well as predict detachment of the closure device 200 from the delivery device 300.
  • indicia 304 can include deployment indicia 306 and release indicia 308.
  • Deployment indicia 306 can be utilized to enable a user to estimate the degree of deployment of the closure device 200 from the catheter 362, and the release indicia 308 can be utilized to predict the detachment of the closure device 200 from the delivery device 300.
  • the handle body 302 can also include a release pin groove 310.
  • the release pin groove 310 can be operatively associated with the release assembly 340 to facilitate the selective detachment of the closure device 200 from the tethers 364.
  • the release assembly 340 can include a biasing member 342 operatively associated with the handle body 302 to facilitate detachment of the closure device 200.
  • a release knob 346 can be provided to manipulate the position of biasing member 342 in order to release or detach the closure device 200.
  • the release knob 346 is coupled to the biasing member 342, such that movement of the release knob 346 can cause movement of the biasing member 342.
  • the biasing member 342 can include a release pin 344 configured to be received in, influenced by and movable in the release pin groove 310. In this manner, release pin groove 310 can restrict, and thereby influence the movement of the biasing member 342 with respect to the handle body 302.
  • the biasing member 342 is configured to interact with the handle body 302 such that when the release pin 344 is positioned in a terminating portion of the release pin groove 310, as illustrated in Figure 4, the biasing member 342 is biased in the proximal direction with respect to the handle body 302. In this manner, the release pin 344 can be moved from the terminating portion of the release pin groove 310, as illustrated in Figure 4, to the opposing terminating portion of the release pin groove 310 adjacent the release indicia 308B by applying force to the biasing member 342 through the release knob 346 in the distal direction, rotating the release knob 346 and then moving the release knob 346 in the proximal direction to release the closure device 200, as illustrated in Figure 1OB.
  • Figure 5A is a cross-sectional view of the distal end of the catheter 362.
  • the catheter 362 includes a delivery portion 366 for use in positioning the catheter 362.
  • the catheter 362 can be made from a resilient material having sufficient axial stiffness to allow a practitioner to position the catheter 362 with respect to an internal tissue opening, and sufficient rotational stiffness to allow a practitioner to rotate the catheter 362 by rotating the handle body 302.
  • the catheter 362 comprises a braided polyimide.
  • the catheter 362 can be made from a material having a sufficient axial stiffness, such as a braid reinforced polymer, axially reinforced polymer, metal reinforced polymer, carbon reinforced polymer, or some other type of axially stiff material.
  • the delivery portion 366 can be made from a thermoplastic elastomer, such as PEB AX®.
  • the delivery portion or tip portion 366 can be made from a material having sufficient flexible properties, such as a polymeric material.
  • the delivery portion 366 can include a combination of materials, such as metallic materials and polymeric materials.
  • the delivery portion 366 can define a lumen 368 to facilitate placement of the catheter 362.
  • a guidewire can be received in the lumen 368 to guide the catheter 362 to a desired location.
  • the closure device 200 can be located proximate to the internal tissue opening in a quick and efficient manner.
  • the delivery portion 366 can be shaped, such as including a bend, in order to facilitate placement of the delivery portion 366 through a PFO, for example.
  • the catheter 362 can be considered a rapid exchange catheter wherein the delivery or tip portion 366 enables a guidewire to be linked to the catheter 362 in a quick and efficient manner for placement of the catheter 362.
  • the catheter 362 and delivery portion 366 can be configured to at least partially house tethers 364 in a lumen which is distinct and separate from lumen 368.
  • lumen 368 can be in a spaced apart, non-coaxial arrangement from the lumen which houses tethers 364, such that a guidewire can be received through lumen 368 without being introduced into the lumen or space in which the tethers 364 are housed.
  • a user can introduce a guidewire into the lumen 368 at the distal end of the catheter 362, rather than the lumen which at least partially houses the tethers 364 which would require the guidewire to be introduced into the lumen at the proximal end of the catheter 362.
  • the lumen 368 configured to receive the guidewire therein can be positioned inside the lumen which houses the tethers 364.
  • lumen 368 would include an opening and an exit at the distal end of the catheter 362 in order to facilitate the quick placement of a guidewire through the lumen 368.
  • catheter 362 can include a rounded cross-section and the delivery portion 366 can include a rectangular cross-section.
  • the rectangular cross- section of the delivery portion 366 can facilitate proper deployment of the closure device 200 from the delivery device 300, as well as facilitate the closure device 200 being reintroduced back into the delivery portion 366.
  • the rectangular cross-section of the delivery portion 366 can be sized to orient the tethers 364 next to each other in a linear fashion. In this manner, the likelihood that the tethers 364 cross each other upon reintroduction of the closure device 200 into the delivery portion 366 can be reduced.
  • tethers 364 includes three tethers 364 A- C, each tether 364 being sized and configured to attach to and/or accommodate therein an attachment member 240 of the closure device 200.
  • a tether is a line or hollow tube coupled to the handle body 302.
  • the tether 364 can comprise a flexible, hollow shaft having sufficient stiffness such that as actuating assembly 320 moves the catheter 362 proximally with respect to the handle body 302, the closure device 200 is forced out of the delivery portion 366.
  • the tether 364 can be configured to pull the closure device 200 back into the delivery portion 366 as the actuating assembly 320 is moved distally with respect to the handle body 302.
  • the tether 364 can be a coil of stainless steel covered by a heatshrunk tubing to give the coil a degree of tensile strength and rigidity.
  • the tether 364 can be a polymeric tube.
  • the tether 364 can be a combination of polymeric materials and metallic materials.
  • an additional heatshrunk tubing covers a proximal segment of the three tethers 364 A-C. The heatshrunk covering can increase the column strength of the tether 364, which can enable the tethers 364 to assist with deployment and reintroduction of the closure device 200 from and into the delivery portion 366.
  • the tethers 364 can have a distal tip configured to correspond to the shape and size of the attachment members 240 of the closure device, such that the attachment member 240 can be received into the distal tip of the tether 364, as illustrated in Figure 7.
  • Tethers 364 can be made from a material having sufficient flexibility to substantially prevent distortion or otherwise influence the orientation of the closure device 200 when the closure device is deployed from the catheter 362, yet have sufficient axial strength to facilitate deployment of the closure device 200 when the catheter 362 is moved proximally with respect to the closure device 200.
  • the tethers 364 can have a lumen extending therethrough of sufficient size and configuration to enable a plurality of wires 378 to be housed and movable therein.
  • Figures 5B-5C are cross-sectional views illustrating the delivery assembly 360 in association with the actuating assembly 320.
  • Figure 5B does not include the biasing member 342 and associated release knob 346
  • Figure 5C illustrates details about the interaction between the delivery assembly 360 and the actuating assembly 320 without illustrating the first member 322 and details about the handle body 302 and the second member 324.
  • the proximal end of the catheter 362 is coupled to the distal end of the second member 324.
  • movement of the second member 324 can cause a corresponding movement in the catheter 362.
  • the catheter 362 move proximally with respect to the handle body 302.
  • the tethers 364 can extend from the delivery portion 366, through the catheter 362 and the second member 324 and are coupled to the handle body 302.
  • the tethers 364 can be coupled to the handle body 302 by, for example, an intermediate member 376.
  • the tethers 364 can be covered with a first and second housing 370, 372 to provide a degree of rigidity to the portions of the tethers 364 located inside of the handle body 302 and the second member 324.
  • the first housing 370 comprises a rigid, hollow, metal rod configured to house the three tethers 364A-C therein.
  • the first housing 370 can extend from the intermediate member 376, which facilitates securement of the tethers 364 to the handle body 302, and terminate at some point beyond the handle body 302.
  • the second housing 372 can extend from the distal end of the first housing 370 and extend into the catheter 362.
  • the second housing 372 can comprise a resilient material configured to resist axial stretching while allowing a degree of bending.
  • the second housing 372 comprises a coil of metal, such as stainless steel, configured to resist axial stretching, yet allow a degree of bending.
  • the second housing 372 can allow a practitioner to bend a portion of the catheter 362, if needed, in order to manipulate delivery device 300 for placement of the closure device 200.
  • a seal 374 can be provided between the first housing 372 and the second member 324 in order to reduce or substantially prevent bodily fluid, which may have entered the catheter 362, from entering the handle body 302 or otherwise inappropriately being expelled from the delivery device 300.
  • the second member 324 can comprise an elongate shaft defining an axial lumen 348 and a lumen 350 in fluid communication therewith.
  • Lumen 350 can be configured to couple to a medical device for removal of fluid from the delivery device 300.
  • the axial lumen 348 can be sized to accommodate and allow movement of the tethers 362, the first housing 370 and the second housing 372 therein.
  • the second member 324 can include a guide 326.
  • the guide 326 can be configured to cooperate with a first pin 352 and a second pin 354 to influence movement of the second member 324 with respect to the handle body 302, as will be discussed more fully herein below.
  • the first member 322 comprises a hollow elongate tube sized and configured to enable the second member 324 to be received into and moveable within the first member 322.
  • the first member 322 can be operatively associated with the handle body 302 and the second member 324 to facilitate deployment of the closure device 200.
  • the first member 322 is linked to the handle body 302 by a third pin 356.
  • the third pin 356 is received in a guide 358 of the first member 322.
  • the guide 358 is configured to interact with the third pin 356 in order to influence the movement of the first member 322 with respect to the handle body 302.
  • the first pin 352 can link the first member 322 to the second member 324.
  • the second pin 354 links the handle body 302 to the second member 324
  • the third pin 356 links the handle body 302 to the second member 322
  • movement of the first member 322 can selectively deploy the closure device 200 from the delivery portion 366.
  • Figure 6 is an exploded view of the actuating assembly 320 and the release assembly 340.
  • the second member 324 is received into the first member 322, and the first member 322 is received into the knob 338 and the handle body 302, as illustrated in Figures 4 and 5B-5C.
  • the second member 324 can include a guide 326 having a first portion 326a and a second portion 326b, which guide 326 can be defined by a slot formed on the outer surface of the second member 324.
  • the first portion 326a is straight and extends along at least a portion of the length of the first member 324 and joins with the second portion 326b of the guide 326.
  • the second portion 326b can include a helical groove or slot that begins with and is contiguous with the first portion 326a and extends distally therefrom.
  • the guide 326 of the second member 324 is configured to interact with the handle body 302 and the first member 322 to selectively retract the catheter 362 in order to deploy the closure device 200.
  • the first portion 326a of the guide 326 is configured to interact with the second pin 354, which is secured into the handle body 302 by means of threads and extend into the first portion 326a of the guide 326.
  • the second member 324 can move laterally with respect to the handle body 302.
  • rotation of the handle body 302 can translate to rotation of the second member 324, and thus, the catheter 362 and the delivery portion 366.
  • the second portion 326b of the guide 326 is configured to interact with the first pin 352, which is secured to the first member 322 by means of threads and extends into the second portion 326b of the guide 326. In this manner, as the first member 322 is rotated, the first pin 352 will interact with the second portion 326b to move the second member 324 in the proximal direction. As the second member 324 is moved in the proximal direction with respect to the handle body 302, the catheter 362 moves proximally with respect to the handle body 302 thereby exposing or deploying the closure device 200 from the delivery portion 366.
  • the first member 322 can include a guide 358 defined by a slot or groove formed in the outer surface of the first member 322.
  • the guide 358 can include a first portion 358a connected to a second portion 358b.
  • the first portion 358a of guide 358 can be straight and extend along at least a portion of the length of the first member 322, and then join and be contiguous with the second portion 358b.
  • the second portion 358b of the guide 358 can be a helical groove that wraps around at least a portion of the outer surface of the first member 322 and extends along at least a portion of the length of the first member 322.
  • the closure device 200 is completely received into and enclosed by the delivery portion 366.
  • the third pin 356 moves in the first portion 358a of the guide 358 to deploy the first anchor 204 of the closure device 200 from the delivery portion 366.
  • the length of the first portion 358a can correspond with the distance that the first member 322, and thus the catheter 362, must move in order to deploy the first anchor 204 of the closure device 200 from the delivery portion 366.
  • a practitioner can move the knob 338, which is coupled to the first member 322, in the proximal direction. Movement of the knob 338 in the proximal direction can cause the third pin 356 to move linearly in the first portion 358a of the guide 358. In this manner, the second member 324 can move correspondingly with the first member 322 because of the first pin 352, which links the first member 322 to the second member 324.
  • the first member 322 can be rotated in order to selectively deploy the remaining portions of the closure device 200 from the delivery portion 366 of the delivery device 300.
  • the third pin 356 is positioned in the second portion 358b to influence movement of the first member 322 with respect to the handle body 302, and the first pin 352, which is coupled to the first member 322, interacts with the second portion 326b of the guide 326 to move the second member 324 in the proximal direction with respect to the handle body 302.
  • Movement of the second member 324 in the proximal direction in this manner can cause further deployment of the closure device 200 from the delivery portion 366.
  • the knob 338 can be coupled to the first member 322 to facilitate and enable movement of the first member 322 with respect to the handle body 302.
  • the dual movement required to deploy the closure device 200 can provide some efficiency and safety advantages.
  • a practitioner can move the knob 338 in a first direction (i.e., proximally in a linear fashion) to deploy the first anchor 204 from the delivery portion 366. Thereafter, the practitioner can move the handle body 302 to position the first anchor 204 against the wall tissue of an internal tissue opening, such as against the left atrial wall of a heart, for example. Once the first anchor 204 is positioned against the wall, the practitioner can move the knob 338 in a second direction (i.e., rotate the knob) to further deploy the closure device 200 from the delivery portion 366.
  • the dual movement enables a user to predict the deployment of the closure device 200 to reduce the risk of premature deployment of the closure device.
  • a structure configured to substantially restrict or control movement of the first element with respect to the second element and/or handle body can be utilized.
  • the structure can include a cam and a follower.
  • the structure can include a slider.
  • the release assembly 340 can be configured to be received in the proximal end of the handle body 302.
  • the release assembly 340 can be configured to provide additional safety features for the practitioner and patient by reducing the risk of premature detachment of the closure device 200 before it is positioned appropriately in an internal tissue opening.
  • a practitioner using the medical system 100 of the present invention can manipulate the actuating assembly 320 to deploy the closure device 200 for positioning in an internal tissue opening.
  • a user can move the knob 338, and thus the first member 322, in the proximal direction with a first movement, which is a linear movement, then deploy the remaining portions of the closure device 200 by a rotational movement.
  • the practitioner can be required to move their hands in order to utilize the release assembly 340 to release the closure device 200 from the delivery device 300.
  • the release assembly 340 can include a release knob 346 coupled to a biasing member 342, which is received into the proximal end of the handle body 302.
  • the biasing member 342 can be configured to include a plurality of slots 318 configured and arranged to act similar to a spring.
  • the slots 318 can be configured and arranged in the biasing member 342 to enable at least a portion of the biasing member 342 to be compressed. Compression of the biasing member 342 can cause the release pin 344 to move toward the distal end of the biasing member 342.
  • the biasing member 342 can be configured such that when biasing member 342 is positioned in the handle body 302, the biasing member 342 naturally tends to maintain its position with the release pin 344 in the release pin groove 310 as illustrated in Figure 4. As force is applied to the release knob 346 in the distal direction (i.e., compress the biasing member 342), the release pin 344 can be moved out of a terminating portion of the release pin groove 310 and rotated and moved into a proximal terminating portion of the release pin groove 310 to release the closure device 200 from the delivery device 300.
  • the closure device 200 is released from the delivery device 300 by moving a plurality of wires 378 which are housed by a tether 364 and coupled to the biasing member 342.
  • Illustrated in Figure 7 is a cross-sectional view of attachment member 240 of the closure device 200 received into a tether 364 and coupled by first and second wires 378a, 378b.
  • a second wire 378b can extend through and out of the tether 364 and form a loop. The loop can extend through an aperture 242 of the attachment member 240 of the closure device 200.
  • a first wire 378a which extends through and out of the tether 364, can extend through the loop of the second wire 378b to form a locking feature.
  • the closure device 200 can remain coupled to the delivery device 300 until the first wire 378a is pulled through the loop of the second wire 378b, and the second wire 378b is pulled out of the aperture 242 of the attachment member 240.
  • the first wire 378a and the second wire 378b can be attached at their proximal ends to the biasing member 342. In this manner, movement of the biasing member 342 in the proximal direction can cause movement of the wires 378 also in the proximal direction.
  • the wires 378 can be coupled to the biasing member 342 such that movement of the biasing member 342 will cause the first wire 378a to move a distance sufficient to be removed from the loop of second wire 378b before the second wire 378b is moved by the biasing member 342.
  • the wire 378 can comprise a metallic wire, such as a NiTiNoI wire.
  • the wire 378 can also include a stainless steel wire or some other type of metal or stiff polymer.
  • the wires 378 can be made from a material having a sufficient tensile strength to secure the closure device 200 to the tethers 364 without causing the wires 378 to fail or substantially deform.
  • the wire 378B can include a stainless steal wire and wire 378A can include a NiTiNoI wire.
  • the release assembly can include a rotating member coupled to the securing elements.
  • rotation of the rotating member can cause the securing elements to wind around the rotating member thereby causing the distal ends of the securing elements to move proximally with respect to the handle body.
  • Figure 8a illustrates the positioning of the catheter 362 through the tunnel 58 of a PFO with the first anchor 204 of the closure device 200 deployed.
  • the medical system 100 is utilized to close an internal tissue opening by positioning the catheter 362 through an internal tissue opening and moving the first member 322 by a first movement (i.e., linearly) in the proximal direction to deploy the first anchor 204 of the closure device 200.
  • the delivery device 300 can be moved in the proximal direction in order to seat the first anchor 204 against the wall of the tissue opening or otherwise engage the wall of the internal tissue opening, as illustrated in Figure 9. This can be done by moving the handle body 302 in the proximal direction.
  • the knob 338 and thus the first member 322 can moved by a second movement, or in other words, rotated to deploy additional portions of the closure device 200 as illustrated in Figure 9.
  • the release assembly 340 can be actuated to selectively detach the delivery device 300 from the closure device 200 as illustrated in Figures 10a and 10b.
  • the release assembly 340 can be actuated by moving the biasing member 342 distally with respect to the handle body 302, then rotating the biasing member with respect to the handle body 302, and then moved proximally with respect to the handle body 302.
  • closure device 200 substantially conforms to the anatomy of the internal tissue opening.
  • the configuration of the closure device 200 is such that when positioned in the internal tissue opening as illustrated, the members of the closure device 200 apply lateral force to the tissue of the internal tissue opening, such as the tunnel 58 of the PFO, to approximate tissue of the PFO for closure.
  • Figure HA illustrates one embodiment of a closure device 200 that can include a member 250, such as an ingrowth material.
  • the member 250 can be configured to induce tissue growth.
  • the member 250 can be fixed to the closure device 200 by means of a securing element, such as a thread 252.
  • the thread 252 can extend through the member 250 and through the apertures in the intermediate portions 234 in order to secure the member 250 to the closure device 200.
  • the member 250 can be secured to the closure device 220 by a known securing means, such as by an adhesive, a heat weld, or some other known or hereafter developed means for securement.
  • the member 250 and the thread 252 can include a bio-resorbable material, such as polylactide or polyglycolide or collagen.
  • the member 250 can be sized and configured to enable the closure device 200 to be deployed from and received into the delivery portion 366 of the delivery device 300. Furthermore, the member 250 can be configured to interact with tissue of the internal tissue opening to stimulate growth of tissue for closure of the internal tissue opening. For example, the member 250 can interact with the tunnel tissue 58 of a PFO in order to stimulate growth of tissue in the PFO tunnel 58.
  • the member 250 can be any suitable material which can or tends to promote tissue growth. Examples of such material can include a polymeric material, or a woven material, such as a woven metallic or biological material.
  • the member 250 can be a piece of foam.
  • the member 250 can be a piece of yarn, fabric or string, or some combination thereof.
  • Other tissue growth promoting members can include a coating disposed on the closure device 200.
  • the member 250 can be a piece of foam, braided material such as a piece of yarn or string, or fabric which has a coating disposed thereon.
  • the member 250 can include materials such as a piece of polyurethane or some other biocompatible polymer, including bio-resorbable polymers.
  • the member 250 can also include Dacron or polymeric threaded material which have been woven or knitted, or formed into compressed, non-woven fabrics.
  • the member 250 can also include a metallic material, such as a NiTiNoI, stainless steal or some other biocompatible alloy or bio-resorbable metal, such as magnesium alloy, or some combination thereof.
  • the member 250 comprises a metallic wire.
  • Figure 1 IB illustrates a side view of the closure device 200, and illustrates one example of the closure device having a substantially flat configuration.
  • the closure device 200 can include a depth or depth thickness designated as DT, and a plane 260 extending perpendicular into and out of the plane of the page.
  • the member 250 can extend beyond at least a first edge 262 of the closure device 200.
  • the member 250 can extend beyond both the first edge 262 and a second edge 264 of the closure device 200. In this manner, member 250 can contact tissue adjacent the closure device 200 to promote tissue growth in the tissue opening.
  • the member 250 can be sized and configured to extend beyond at least the first edge 262 of the closure device 200 a sufficient distance to contact tissue of the tissue opening.
  • the member 250 can extend beyond at least the first edge 262 a sufficient distance to contact tissue adjacent the first edge 262, thereby causing the end of the member 250 which is in contact with the tissue to deflect or bend. In this manner, more surface area of the member 250 can be in contact with tissue to thereby facilitate an increase in tissue growth. In other embodiments, the member 250 can extend beyond both the first edge 262 and the second edge 264 a sufficient distance to cause both ends of the member 250 to bend, which can result in more surface area contacting the tissue. In one embodiment, the member 250 can extend between at least .5mm and 5mm beyond the first edge 262.
  • the member 250 can extend between at least .5mm and 5mm beyond the first edge 262, and can extend between at least .5mm and 5 mm beyond the second edge 264. Furthermore, the member 250 can have a thickness of between at least .25mm and 2mm.
  • the member 250 can be configured to decrease the size of a remaining void in the tissue opening after the closure device 200 has been positioned in the tissue opening.
  • Member 250 extending beyond the first edge 262 of the closure device 200 is an example of the member 250 extending substantially out of plane of the substantially flat configuration.
  • the present invention can also include the following methods, systems and devices.
  • a medical device comprising: a body portion comprising two or more cells, said body portion being movable between a deployed and non-deployed orientation; and at least one anchor linked to said body portion, said at least one anchor being adapted to reduce proximal movement of the medical device when the medical device is positioned in an internal tissue opening.
  • a medical device comprising: a multi-cellular structure adapted to selectively expand and contract between a deployed and non-deployed orientation; a first anchor operatively associated with said multi-cellular structure, said first anchor being adapted to selectively engage at least a portion of a wall of an internal tissue opening; and a second anchor operatively associated with said multi-cellular structure, said second anchor being adapted to engage at least a portion of at least another portion of the wall of the tissue opening.
  • a method for closing a Patent Foramen Ovale comprising the steps of: positioning at least a portion of a medical device into a left atrium of a heart, said medical device comprising a first anchor, a multi-cellular structure linked to said first anchor, and a second anchor linked to said multi-cellular structure, said first anchor, said multi-cellular structure and said second anchor being adapted to selectively move between a non-deployed and deployed orientation; locating at least a portion of said first anchor against at least a portion of a left atrial wall of the heart; and locating at least a portion of said second anchor against at least a portion of at least one of a tunnel of the Patent Foramen Ovale or a right atrial wall of the heart.
  • a medical device for approximating tissue of an internal tissue opening together comprising: a body portion comprising two or more cells, said body portion being adapted to apply lateral force to tissue of an internal tissue opening; and at least one anchor operatively associated with said body portion.
  • a medical device for approximating tissue of an internal tissue opening together comprising: a multi-cellular structure adapted to selectively expand and contract between a deployed and non-deployed orientation, said multi-cellular structure configured to preferentially expand; and at least one anchor operatively associated with said multi-cellular structure, said at least one anchor being adapted to move between a deployed and non-deployed orientation, at least a portion of said at least one anchor being adapted to apply lateral force to at least a portion of tissue of an internal tissue opening when said first anchor is deployed.
  • a method for reducing the size of an internal tissue opening comprising the steps of: positioning at least a portion of a medical device through an internal tissue opening, said medical device comprising a multi-cellular structure and at least a first anchor associated with said multi-cellular structure, said at least one anchor and said multi-cellular structure being adapted to selectively move between a non-deployed and deployed orientation; and applying lateral force to tissue of the internal tissue opening by at least partially deploying said at least one anchor.
  • a medical device comprising: two or more cells forming a body portion, said body portion being adapted to move between a collapsed and expanded orientation to apply lateral force to tissue of an internal tissue opening; and at least one anchor linked to said body portion, said at least one anchor being adapted to extend distally when said at least one anchor is collapsed and extend laterally when said at least one anchor is moved from a collapsed to an expanded orientation.
  • a method for deploying a closure device comprising the steps of: deploying a left anchor of a closure device from a delivery device, said delivery device comprising an actuating assembly operatively associated with a handle body, said left anchor being adapted to deploy by linearly moving at least a portion of said actuating assembly with respect to said handle body; and deploying a second anchor of said closure device from said delivery device by rotating at least a portion of said actuating assembly with respect to said handle body.
  • a delivery device for an internal tissue opening closure device comprising: a handle body including first and second guide members; a first member operatively associated with said handle body, at least a portion of said first member defining a guide, said first guide member cooperating with said guide to influence movement of said first member with respect to said handle body, said first member including a guide structure; and a second member operatively associated with said first member, at least a portion of said second member defining a second guide, said guide structure cooperating with said second guide to influence the movement of said second member with respect to said first member, and said second guide member cooperating with said second guide to influence the movement of said second member with respect to said handle body.
  • a delivery device for an internal tissue opening closure device comprising: a handle body; a first pin coupled to said handle body; a second pin coupled to said handle body; a first cam adapted to be at least partially received into and movable with respect to at least a portion of said handle body, said first cam including a slot formed on an external surface of said first cam, said slot including a first portion and a second portion, said first portion of said slot extending along at least a portion of the length of said first cam, said second portion of said slot extending at least partially around said first cam, said first pin received in said slot; a third pin coupled to said first cam; and a second cam adapted to be at least partially received into and movable with respect to at least a portion of said first cam, said second cam including a first and second slot formed on an external surface of said second cam, said first slot of said second cam extending at least partially around said second cam and said second slot of said second cam extending along at least a portion of the length of said second cam, said third pin received in said
  • a medical device for closing an internal tissue opening comprising: a multi-cellular structure configured to assume a substantially flat configuration; at least one anchor operatively associated with said multi-cellular structure, said at least one anchor comprising a plurality of segments at least partially defining a closed periphery.
  • a medical device for closing an internal tissue opening comprising: a multi-cellular structure adapted to be moveable between a first orientation and a second orientation; at least one anchor operably associated with said multi-cellular structure; and a tissue growth member associated with said multicellular structure, said tissue growth member being adapted to enhance tissue growth in the internal tissue opening.
  • a medical device that has a multi-cellular structure being configured to be moved from a collapsed state to an expanded state, the multi-cellular structure including a waist portion and at least one anchor portion, wherein the anchor portion is wider in the expanded state of the device than the waist portion and the waist portion is configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening.
  • This device can also include one or more distal anchors and/or proximal anchors. These anchors can be substantially the same width, or one may be wider than the other. These anchors may also include a plurality of elongate arms.
  • One or more of the elongate arms may have a serrated edge, such as a serrated edge is configured to face toward the center of a tunnel of an internal tissue opening when the medical device is deployed.
  • the elongate arms may also have smooth edges.
  • the multi- cellular structure may include a plurality of cellular portions having substantially the same size or the cellular portions may be of different sizes.
  • the medical device may also be configured to shorten its overall length dimension upon deployment. If the medical device has a distal anchor and a proximal anchor, the proximal anchor may be configured to roll at least partially onto itself upon deployment to shorten the overall length of the medical device upon deployment.
  • the medical device may a spring member secured to the waist and a solid anchor portion.
  • the solid anchor portion may be a solid proximal anchor portion.
  • the waist portion of the medical device may also include a hinged portion.
  • the medical device may be formed of a resilient material such that the medical device is configured to expand from the compressed state to the expanded state due at least in part to spring forces associated with the resilient material.
  • the medical device may also be configured to be expanded from the compressed state to the expanded state mechanically.
  • a medical device includes opposing expansion members and at least one connecting member coupling the opposing expansion members.
  • the connecting member may be configured to move the opposing expansion members from a compressed state to an expanded state to seal an internal tissue opening.
  • the medical device may also include a plurality of connecting members and pinned joints between adjacent connecting members and between the connecting members and the opposing expansion arms.
  • the pinned joints may include a ratcheting mechanism configured to allow the connecting members to move relative to each other to allow expansion of the expansion members during deployment but to prevent the expansion members to collapse after deployment of the medical device.
  • the medical device may further include an actuation member, such as a cable or tether, coupled to at least one connecting member.
  • the expansion arms may be configured to be expanded from the compressed to the expanded state by drawing the actuation member proximally.
  • the medical device may also include a locking member configured to lock the expansion member in the expanded state.
  • the locking member may include a clasp operatively associated actuation member.
  • the connecting member may have a strut and piston configuration.
  • a medical device includes a plurality of elongate arms and an actuation member coupled to the elongate arms, the actuation member being configured to mechanically expand the elongate arms from a collapsed position to an expanded position.
  • the actuation member may include alternating thinner portions between relatively thicker portions.
  • the actuation member may be configured to be drawn proximally and/or moved distally to mechanically expand the elongate arms.
  • the medical device may also include a body portion operative associated with the elongate arms.
  • the body portion may include flexing sections and/or pivots coupling the elongate arms to the body portion.
  • the medical device may be a distal locator device, a proximal locator device, and/or a closure device.
  • a medical system in yet another configuration, includes a first medical device having expandable elongate arms, the expandable elongate arms being configured to expand from a collapsed state to an expanded state and to locate an opening of an internal tissue opening, and a second medical device operatively associated with the first medical device, the second medical device having a multi-cellular structure being configured to be moved from a collapsed state to an expanded state, the multi-cellular structure including a waist portion configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening.
  • the first medical device may be a distal locator device or a proximal locator device.
  • the first medical device may be configured to locate a distal opening of the internal tissue opening.
  • the system may further include a third medical device operatively associated with the second medical device, wherein the third medical device includes expandable elongate arms, the expandable elongate arms being to expand from a collapsed state to an expanded state and to locate a proximal opening of the internal tissue opening.
  • the second medical device may include outwardly facing tines, first anchor portions, and/or second anchor portions.
  • a device for releasing an implant within a body lumen includes an attachment member coupled to the implant, a push member operatively associated with the attachment member.
  • the device may be configured to secure the implant to a delivery device before release of the implant and to selectively release the attachment member.
  • the attachment member may have a post configuration and the push member has a hole defined therein to receive the post.
  • the attachment member may include a loop of material coupled to the push member and a pin, the loop extending through a hole formed in the attachment member and being secured to the attachment member by the pin, wherein removing the pin releases the attachment member.
  • the attachment member may also include a tab while the push member includes a pin configured to retain the tab in contact with the push member.
  • the tab may have a dog-leg shape.
  • the push member may include a slot defined therein configured to receive a portion of the tab while the device further includes a release wire configured to retain the tab in the slot and to be withdrawn to release the tab from the slot.
  • the pin and tab may be interlocking members held in engagement while retained within the push member and that are released when moved from the push member.
  • the push member may be formed from a meltable material.
  • the device may further include a coil of electrically conductive wire in which a portion of the push member extends at least partially through the coil. The device is configured to release the attachment member by heating the coil to melt a portion of the push member. Insulation may surround at least a portion of the coil.
  • the device may also include a current source configured to provide a direct current and/or alternating current to the coil.
  • the current source may be configured to provide an alternating current to the coil at a frequency up to radio frequencies.
  • the coil may also be configured a resistive temperature device and may be formed from nickel, copper, and/or platinum or any other suitable material.
  • the device includes bimetallic actuator configured to release the attachment member from the push member at a specified temperature range.
  • the bimetallic actuator may include a bimetallic strip and a securing member operatively associated with both the attachment member and the push member.
  • the securing member may be configured to couple movement of push member to the attachment member when engaged and to be disengaged at a specified temperature range to decouple the attachment member from the push member.
  • the push member and the attachment member may each include a receiving portion, such as a loop, defined therein which allows the securing member to pass at least partially through each of the receiving portions.
  • the bimetallic actuator may be secured directly to the securing member and/or a linkage may couple the bimetallic strip and the securing member.
  • a pivot may also be coupled to the linkage member.
  • Example 66 A device according to example 65, further including a pivot coupled to the linkage member.
  • the linkage member may include a first portion proximate the bimetallic strip relative to the pivot and a second portion proximate the bimetallic strip relative to the pivot in which the first portion is shorter than the second portion.
  • a medical device further includes a shape-memory actuator configured to move between an initial shape below a transition temperature and a preset shape above the transition temperature to secure the attachment member in the initial shape and release the attachment member when moved to the preset shape.
  • the push member may include a receiving portion.
  • the shape memory actuator may extend through the receiving portion in the initial shape to secure the push member to the attachment member and wherein the shape memory actuator is drawn from engagement with the receiving portion when moved to the initial state to release the push member from attachment member.
  • the attachment member has a recess defined therein and the shape memory actuator engages the recess when in the initial state and is released from engagement with the recess when moved to the preset shape.
  • the device may include a cutting feature secured to the shape memory actuator, the cutting feature being configured to cut a portion of the push member when the shape memory actuator is moved to the preset shape.
  • cutting feature may have an opening defined therein and at least a portion of the push member may extend through the opening.
  • the device may include a linkage and a securing member, the linkage coupling the shape memory actuator to the securing member. The securing member may couple the push member to the attachment member when the shape memory actuator is in the initial shape and release the push member from the attachment member when the shape memory actuator is in the preset shape.
  • a pivot may also be operatively associated with the linkage.
  • a device in another example, includes a cylinder and piston secured to the implant, a linkage, and a securing member.
  • the securing member may be configured to release the push member in response to operation of the cylinder and piston, such as by expansion of the cylinder and piston.
  • a phase change material may be expanded within an enclosed space of the cylinder to drive the piston.
  • Phase change materials may include a hydro-carbon fluid as well as formulations of waxes such as those used in the thermostats of common automotive engine thermostats.
  • a cross hole is defined in the push member and a hole is defined in the attachment member.
  • the device may further include a flexible filament extending through the cross hole through the hole and into a distal end of the push member.
  • the device may include a cutting feature. The cutting feature may engage the filament at the cross hole to cut the filament.
  • a delivery device for delivering a closure device includes a handle body and a pusher handle operatively associated with the handle body, the pusher handle having a guide slot defined therein.
  • the guide slot may be configured to allow the pusher handle to move linearly with respect to the handle body a first linear distance to deploy a first portion of the closure device.
  • the guide slot may be further configured to allow the pusher handle to move linearly with respect to the handle body additional linear distances to deploy additional portions of the closure device, such as a second linear distance to deploy a second portion of the closure device.
  • the guide slot may be configured to allow the pusher handle to rotate a rotational distance between the first linear distance and the second linear distance.
  • First and second grooves may be defined in the handle body while first and second stops may be associated with the first and second grooves.
  • the first and second stops may be associated with the guide slot.
  • the first and second stops are configured to move between initial positions and rotated positions to constrain the movement of pusher handle. For example, rotating the first stop to the rotated position allows the pusher handle to move from the first position to the second position and rotating the second stop to the rotated position after rotating the first stop to the rotated position allows the pusher handle to move from the second position to the third position.
  • the linear distance from the first position to the second position may correspond to the first linear distance and the distance between the second position and the third position may correspond to the second linear distance.
  • the guide slot includes a first linear portion, a transverse portion transverse to the first linear portion and in communication with the first linear portion, and a second linear portion substantially parallel to the first linear portion, the second linear portion in communication with the transverse portion.
  • the delivery device may also include a release assembly configured to release the closure device from the delivery device.
  • the release assembly may include a release cap having a slot defined therein, the slot having a linear portion and a transverse portion transverse to the linear portion in which the linear portion extends proximally of the linear portion.
  • the slot may also include a detent formed defined therein in communication with the transverse portion.
  • a pin is coupled to the handle portion and is operatively associated with the pin.
  • the delivery device may also include a drain lumen in fluid communication with the handle body.
  • a medical device has a multi-cellular structure being configured to be moved from a collapsed state to an expanded state, the multi-cellular structure including a waist portion configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening, and in-growth media having an ingrowth configuration secured to the medical device.
  • the in-growth configuration may include at least one filament secured to a central portion of the medical device, a filament coiled around the central portion of the medial device, and/or anchoring points configured to have the in-growth media secured thereto.
  • the anchoring points may allow the filament to be secured to the medical device by sewing, fixing by adhesive, and/or knots.
  • the in-growth media also include strips of in-growth media.
  • the strips may be formed of a loosely woven gauze-like material that is woven into an interlocking structure. The strips may also be wrapped around a cellular portion of the closure device.
  • the in-growth media may also include a membrane.
  • the in-growth media may be located at least partially between the closure device and an adjacent closure device. The closure device and the adjacent closure device may be different or may be substantially similar.
  • a medical device has multiple chambers configured to be inflated from a collapsed state to an expanded state, the multiple chambers having a waist portion configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening.
  • the multiple chambers may a distal anchor portion and/or a proximal anchor portion.
  • the distal anchor portion may be configured to be inflated first and the proximal anchor portion may be configured to be inflated subsequent to inflation of the proximal anchor portion, such as second.
  • the multiple chambers may be interconnected, isolated or a mix of the two.
  • the multiple chambers may also be formed of bioresorbable materials.
  • a method for detaching a tether from an implant within a body lumen includes positioning an implant within a body lumen, a tether being coupled to the implant to aid with positioning the implant within the body lumen, and applying at least one of an electrical input or a thermal input to the tether to detach the tether from implant.
  • Applying at least one of an electrical input or a thermal input may include applying electrical input to the tether to melt the tether and detach the tether from the implant, applying thermal input to a bimetallic actuator to remove a securing member from engagement with the tether and detach the tether from the implant, applying thermal input to a shape memory actuator releasably coupled to the implant to move a portion of the shape memory actuator relative to the implant to disengage from the tether and detach the tether from the implant, applying thermal input to a shape memory actuator, the shape memory actuator being mounted to a cutting structure that at least partially surrounds the tether, wherein the thermal input moves the shape memory actuator and the cutting structure to cut the tether and detach the tether from the implant, and/ or applying thermal input to a phase change assembly resulting detaching of the tether from the implant.
  • a medical device deployable at least partially within a tissue structure comprising: a framework configured to assume a substantially flat configuration, said framework comprising a central portion and at least one anchor extending from said central portion, said central portion including central frame portions having a length and a width, wherein the width of at least one of said central frame portions varies along at least a portion of the length of said at least one of said central frame portions.
  • a medical device deployable at least partially within a tissue structure comprising: a framework configured to assume a substantially flat configuration, said framework comprising a central portion and at least one anchor extending from said central portion, said central portion including a plurality of central frame portions, at least one of said plurality of central frame portions including a first portion and a second portion, said first portion having a greater rigidity than said second portion.
  • a medical device deployable at least partially within a tissue structure comprising: a framework configured to assume a substantially flat configuration, said framework comprising a central portion and at least one anchor extending from said central portion, said central portion including central frame portions, at least one of said central frame portions having an aspect ratio of a depth dimension to a lateral width dimension of at least about 2 to 1.
  • a medical device deployable at least partially within a tissue structure comprising: a frame configured to assume a substantially flat configuration, said frame comprising a central portion and at least one anchor, said at least one anchor extending from said central portion and connecting to said frame, wherein said at least one anchor defines a closed periphery of said frame.
  • a medical device deployable at least partially within a tissue structure comprising: a frame configured to assume a substantially flat configuration, said frame including at least one anchor configured to adapt to different sizes of tissue structures, said at least one anchor including an undulation configured to facilitate movement of the medical device between an non-deployed orientation and a deployed orientation.
  • a medical device deployable at least partially within a tissue structure comprising: a frame configured to assume a substantially flat configuration, said frame comprising a central portion and at least one anchor, said at least one anchor including multiple anchor portions extending from said central portion, said multiple anchor portions being configured to position and stabilize said frame.
  • a medical device deployable at least partially within a tissue structure comprising: a unitary frame configured to assume a substantially flat configuration, said unitary frame including a central portion and at least one anchor extending from said central portion.
  • a method of forming a medical device comprising: positioning a material; and removing portions of said material to form a unitary medical device from said material, said medical device comprising a non-tubular body portion having a plurality of interconnecting body support segments, said plurality of body support segments defining one or more cells, and an anchor operatively associated with said body portion.
  • a method for measuring characteristics of a tissue structure comprising the steps of: positioning at least a portion of a medical device in the tissue structure, said medical device comprising a multi-cellular structure, at least one anchor linked to said multi-cellular structure, and two or more indicators; and measuring a physical characteristic of the tissue structure utilizing said two or more indicators of said medical device.
  • a method for measuring the tunnel width of a Patent Foramen Ovale comprising the steps of: locating at least a portion of a medical device in a tunnel of the Patent Foramen Ovale of a heart, said medical device comprising a multi-cellular body portion, a first anchor linked to said multi-cellular body structure and a second anchor linked to said multi-cellular body structure; positioning said first anchor against a left atrial wall of the heart; deploying said second anchor; and measuring the tunnel width of at least a portion of the tunnel of the Patent Foramen Ovale utilizing at least one of said first anchor, said second anchor or said multi-cellular body portion.
  • a method for verifying the placement of a medical device comprising the steps of: deploying at least a portion of a first anchor of a medical device in the left atrium of a heart, said medical device comprising a multi-cellular structure operatively associated with said first anchor, a second anchor operatively associated with said multi-cellular structure, and two or more indicators; deploying at least a portion of said second anchor in at least one of a tunnel of a Patent Foramen Ovale or the right atrium of the heart; and estimating placement of said medical device with respect to the Patent Foramen Ovale utilizing said two or more indicators.
  • a system reducing the size of an internal tissue opening comprising: a handle body; and a release assembly operatively associated with said handle body, said release assembly comprising a release coupler extending at least partially through said handle body, said release coupler being selectively coupled to a closure device, and a release actuator coupled to said release coupler, said release actuator including one or more slots, said one or more slots being adapted to facilitate actuation of said release actuator.
  • a delivery device for positioning a closure device comprising: a handle body; one or more tethers coupled to said handle body; and a release assembly operatively associated with said handle body, said release assembly comprising a release mechanism extending through a first tether and engaging the closure device, and a release actuator coupled to said release mechanism, said release actuator being adapted to selectively draw at least a portion of said release mechanism proximally to release the closure device.
  • a method for detaching a closure device from a delivery device, the closure device being deployed within an internal tissue opening comprising: positioning a closure device within an internal tissue opening, a tether and a release mechanism being operatively associated with said closure device to aid with positioning said closure device within the tissue opening, said release mechanism extending at least partially through said tether, wherein at least a portion of said closure device is positioned inside of said tether; and drawing at least a portion of said release mechanism proximally relative to said tether to thereby release said closure device.
  • a system for treating a tissue structure comprising: a handle body; a catheter coupled to said handle body; a tip portion extending from a distal end of said catheter; one or more tethers coupled to said handle body and extending through said catheter; and a medical device configured to assume a substantially flat configuration, said medical device comprising a frame with a central portion and a proximal anchor extending from said central portion, said proximal anchor configured to be coupled to said one or more tethers and configured to deflect proximally from said central portion when constricted in said tip portion.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un système médical servant à traiter une ouverture de tissu interne, lequel système peut comprendre un dispositif de fermeture et un dispositif d'administration associé. Le dispositif de fermeture peut comprendre une partie de corps associée de façon fonctionnelle à une première et à une seconde ancre. La partie de corps peut comprendre une pluralité de segments définissant une structure multicellulaire. Le dispositif de fermeture peut être configuré pour appliquer une force latérale au tissu de l'ouverture de tissu interne pour rassembler le tissu. Le dispositif de fermeture peut avoir un aspect sensiblement plat, et avoir une épaisseur de profondeur sensiblement supérieure à l'épaisseur ou à la largeur d'une majorité des éléments formant le dispositif de fermeture pour réduire la courbure hors du plan. Le dispositif de fermeture peut également comprendre un élément conçu pour induire la croissance du tissu.
EP07840828.3A 2006-08-09 2007-08-09 Dispositifs pour réduire la dimension d'une ouverture de tissu interne Withdrawn EP2068777A4 (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US82194706P 2006-08-09 2006-08-09
US82194906P 2006-08-09 2006-08-09
US82950706P 2006-10-13 2006-10-13
US86604706P 2006-11-15 2006-11-15
US94262507P 2007-06-07 2007-06-07
US11/836,051 US8840655B2 (en) 2006-08-09 2007-08-08 Systems and devices for reducing the size of an internal tissue opening
US11/836,013 US8864809B2 (en) 2006-08-09 2007-08-08 Systems and devices for reducing the size of an internal tissue opening
US11/836,016 US9220487B2 (en) 2006-08-09 2007-08-08 Devices for reducing the size of an internal tissue opening
US11/836,026 US20080039743A1 (en) 2006-08-09 2007-08-08 Methods for determining characteristics of an internal tissue opening
US11/836,000 US9138208B2 (en) 2006-08-09 2007-08-08 Devices for reducing the size of an internal tissue opening
US11/836,123 US8167894B2 (en) 2006-08-09 2007-08-08 Methods, systems and devices for reducing the size of an internal tissue opening
US11/836,037 US8979941B2 (en) 2006-08-09 2007-08-08 Devices for reducing the size of an internal tissue opening
PCT/US2007/075611 WO2008036478A2 (fr) 2006-08-09 2007-08-09 Dispositifs pour réduire la dimension d'une ouverture de tissu interne

Publications (2)

Publication Number Publication Date
EP2068777A2 true EP2068777A2 (fr) 2009-06-17
EP2068777A4 EP2068777A4 (fr) 2013-05-15

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EP07840825.9A Withdrawn EP2068759A4 (fr) 2006-08-09 2007-08-09 Procédés, systèmes et dispositifs destinés à réduire la taille d'une ouverture de tissu interne
EP07840828.3A Withdrawn EP2068777A4 (fr) 2006-08-09 2007-08-09 Dispositifs pour réduire la dimension d'une ouverture de tissu interne

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EP (2) EP2068759A4 (fr)
JP (2) JP2010500130A (fr)
AU (2) AU2007286171A1 (fr)
CA (2) CA2659109A1 (fr)
NZ (2) NZ574738A (fr)
WO (2) WO2008021969A2 (fr)

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Publication number Publication date
WO2008021969A3 (fr) 2008-11-13
AU2007297516A1 (en) 2008-03-27
JP2010500129A (ja) 2010-01-07
WO2008036478A3 (fr) 2008-12-18
EP2068777A4 (fr) 2013-05-15
JP5334850B2 (ja) 2013-11-06
EP2068759A4 (fr) 2013-04-10
WO2008036478A2 (fr) 2008-03-27
CA2659109A1 (fr) 2008-03-27
NZ574738A (en) 2012-02-24
AU2007286171A1 (en) 2008-02-21
CA2659365A1 (fr) 2008-02-21
EP2068759A2 (fr) 2009-06-17
NZ574737A (en) 2012-05-25
JP2010500130A (ja) 2010-01-07
WO2008021969A2 (fr) 2008-02-21

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