Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M2005/2006—Having specific accessories
  • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M2005/206—With automatic needle insertion
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
  • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin

Definitions

• the invention relates to an injection device for the administration of an injectable product, such as a liquid medicament such as insulin, heparin, a growth hormone or an osteoporosis preparation.
• an injectable product such as a liquid medicament such as insulin, heparin, a growth hormone or an osteoporosis preparation.
• the injection device may in particular be an injection pen.
• an injection device which has a switching element and a triggering element.
• the switching element is movable approximately along a longitudinal axis of the injection device from a starting position via a coupling position into a release position.
• the triggering element has a control surface which, when the switching element is in the coupling position, can be moved with a movement transverse to the longitudinal axis, wherein the control surface slides on a cam of the switching element, so that the switching element is moved in the proximal direction.
• the user of the device can start the injection process only by pressing the trigger element when the switching element is in the coupling position.
• the switching element is moved to the coupling position by pressing a Nadelabdeckelement on the injection site.
• the user of the injection device can not determine whether he has placed the injection device so firmly on the puncture site, that the switching element is in the coupling position, whereby a triggering of the device would be possible.
• Such an injection device is particularly preferably an auto-injector.
• the administration of a medicament may, for example, include a piercing sequence in which a needle is pierced into a body tissue and a delivery sequence in which the liquid medicament, for example, is dispensed.
• the Aus thoroughlysequenz or preferably the Einstechsequenz in which can follow a Aus thoroughlysequenz subsequently be activated.
• the invention is based on the assumption that the injection device comprises a switching element which can be moved from a starting position via a coupling position into a release position approximately along a longitudinal axis of the injection device.
• the device may comprise a housing which comprises, for example, two housing parts which are detachably or non-detachably connectable to each other.
• a housing which comprises, for example, two housing parts which are detachably or non-detachably connectable to each other.
• a mechanical sequence control which controls the puncture and / or Aus commonlysequenz can be accommodated, for example, in a proximal housing part and a product container in a distal housing part.
• proximal is meant the side opposite the needle and “distal” is understood to mean the side of the in particular elongate injection device lying on the needle.
• the product container in particular an ampoule, can be exchangeably inserted into the distal housing part or can be formed directly from the distal housing part.
• a transmission member can be mounted, which is displaceable relative to the housing along the longitudinal axis of the injection device against the force of a resilient element, for example a spring, in the proximal direction.
• the transfer member may be connected to a needle cover or itself form a needle cover, which may have at its distal end an opening for the exit of a mounted on the product container needle.
• the transmission member may be coupled to the switching element, for example via cooperating end faces, such that the transmission member entrains the switching element upon movement of the transmission member in the proximal direction of the switching element. Such movement is generated, for example, when placing and pressing the transfer member or the needle cover on the body tissue.
• the switching element can for example be held by an elastic element, such as a spring in its initial position, wherein the switching element is movable against the spring force in a coupling position and from the coupling position to a release position.
• an elastic element such as a spring
• the switching element In the starting position of the switching element no sequence can be triggered or activated.
• a sequence In the coupling position of the switching element, a sequence can be activated by the switching element is moved to the release position. In the release position of the switching element, the sequence is activated.
• the injection device further has a triggering element, which is transversely, preferably in approximately perpendicular to the longitudinal axis movable.
• the triggering element and the switching element can be coupled together so that they can move each other, in particular to move.
• the triggering element can be moved during a movement of the switching element from the starting position into the coupling position of the switching element transversely to the longitudinal axis, in particular against the force of a resilient element.
• the elasticity element may, for example, be a spring which can push the triggering element in a direction opposite to the direction of movement in which the triggering element moves when the switching element is moved from the starting position to the coupling position.
• the triggering element may move the switching element in, for example, a distal direction when the triggering element is actuated in the coupling position of the switching element.
• the actuation of the triggering element may, for example, be performed by a user of the device.
• the trigger element Upon actuation of the trigger element, the trigger element is moved in particular in the direction opposite to the direction which executes the triggering element in the movement from the starting position to the coupling position.
• the spring can act in its actuating direction, wherein the force of the spring is preferably insufficient to actuate the actuating element.
• the switching element is therefore actuated in several, in particular in two stages.
• the movement of the switching element from the starting position to the coupling position is preferably achieved by movement of the transmission member in the proximal direction up to caused an end stop. In the end stop, the switching element is in the coupling position and can no longer be moved by the transmission member.
• the second stage of movement in the distal direction namely from the coupling position to the release position, can be effected only by actuation of the trigger element, whereby the movement of the trigger element is converted into a movement of the switching element.
• the switching element may have a control surface element.
• the control surface element and the switching element can be made in one piece.
• the cam member may be a cam-shaped projection of the switching element.
• the triggering element can slide on the control surface element, in particular on a control surface of the control surface element.
• the elastic element can press the trigger element against the control surface element, in particular the control surface.
• the cam member may also include a plurality of cam surfaces, the cam member having at least one cam surface inclined against the longitudinal axis of the device.
• the at least one control surface may have a variable or a constant inclination or slope in the direction of the longitudinal axis.
• the control surface element may have a plurality of constant or variably inclined control surfaces, which are composed, wherein at the transitions at which the control surfaces meet, their inclinations or gradients may be discontinuous.
• a control surface may be provided which may be approximately parallel to the longitudinal axis of the device.
• the housing in particular the proximal housing part on a housing portion having an opening through which access of a user to an actuating element which is coupled to the trigger element, in particular integrally connected, is possible when the switching element is in the coupling position
• An access of the user to the actuator may be, for example not readily possible when the switching element is in the starting position.
• the actuating element may be, for example, a button arranged on the triggering element, which raises or lowers depending on the switching state of the switching element, in particular over the level of the housing part or below the level of the housing part. For example, if the actuator is in an initial state below the housing level or is approximately flush with the housing level, the user of the device can visually or haptically recognize when the injection device is ready for administration that the housing member protrudes from the housing.
• the triggering element can preferably drive the switching element.
• the trigger element for example, have a control surface which is inclined relative to the longitudinal axis of the injection device, wherein the control surface cooperates with the switching element so that the switching element is moved from the coupling position to the release position when the trigger element is actuated in the coupling position of the switching element.
• the control surface may preferably point in the proximal direction and in the actuating direction of the actuating element.
• the control surface of the trigger element may be a gear surface which slides on the control surface element upon actuation of the trigger element along.
• the gear surface may have a continuous or a variable pitch along the longitudinal axis of the device.
• a plurality of control surfaces may be provided which have a discontinuous or a continuous transition at the points where they are composed.
• the trigger element which has at least one control surface, for example, may be cam-shaped. It is preferred that at least one of the at least one cam element and / or at least one of the at least one cam-shaped section of the trigger element are arranged at a distance from a plane which is spanned by the longitudinal axis of the injection device and the direction of movement of the trigger element.
• the triggering element may for example be forked, so that it is the longitudinal axis of the injection device or an element arranged around the longitudinal axis of the injection device, such as, for example at least one of a mechanism holder, a feed element, a driven member and serving for driving the output member elastic element engages around.
• a cam with a control surface is arranged on each fork element. Furthermore, each cam can cooperate with a respective control surface element of the switching element.
• the injection device with the transfer member in particular the needle cover
• the transfer member shifts in the proximal direction, but without the needle protruding from the needle cover, so that the needle does not yet penetrate into the body tissue can.
• the switching element is in the starting position or in the coupling position.
• the shift element is taken along a path that is less than or equal to the maximum travel.
• the actuating element is moved to a position in which it can be actuated.
• the switching element In this position, namely the coupling position of the switching element, the switching element is moved by a distance by operating the trigger element, which can be set, for example, as an axial distance between the transmission member and the switching element.
• the transmission element and the switching element can be held by a common spring or a spring in each case in a distal position or the starting position.
• the injection device may include a feed element that is biased against the force of a resilient means, such as a spring.
• the switching element may block a release movement of a locking member which blocks the advancing member from moving in the distal direction and releases it in the release position for distal movement.
• the locking member is held in the initial position until in the coupling position of the switching element of the switching element in engagement with the feed element.
• the switching element may have a holding step, which is movable along the longitudinal axis along the locking member, wherein the holding step may be approximately parallel to the axis.
• the locking member may for example be integrally formed on a mechanism holder.
• the retaining step has at least one axial length, which is the way corresponds to the switching element is moved from the starting position to the coupling position.
• the holding step which can be integrally formed by the switching element between the starting and coupling position is approximately at the axial height with the locking member, whereby the locking member is held in engagement with, for example, a locking groove of the advancing element.
• a release step can adjoin the holding step along the longitudinal axis, which is displaced in the movement of the switching element from the coupling position to the release position at approximately the axial height with the locking member, so that the locking member disengages from the feed element, whereby a Einstechsequenz can be started.
• the release stage preferably adjoins the retaining step on one side, which is opposite to the direction of movement of the switching element from the coupling position into the release position.
• the holding step has a smaller distance from the longitudinal axis than the release step.
• the released feed element is displaced in the distal direction until it engages with a blocking element in the mechanism holder, whereby an output member is released, so that the output member can move relative to the feed element in the distal direction, in particular for a product distribution.
• the invention further relates to a method for triggering a triggering mechanism of an injection device.
• a trigger element can be pressed onto a control surface of a switching element.
• the switching element is moved from a starting position along a longitudinal axis of the injection device into a coupling position, wherein the pressed trigger element slides along the control surface and carries out a movement transversely to the direction of movement of the switching element.
• an effective release movement of the trigger element can be performed.
• the movement of the trigger element can take place transversely to the direction of movement of the switching element.
• the switching element is driven in the same direction as it executes in the movement from the starting position to the coupling position.
• the switching element is driven in the same direction until it reaches the release position, whereby preferably the Einstechsequenz and then the Aus thoroughlysequenz be activated. Further advantageous process features result from the operation of the injection device according to the invention.
• Figure 1 is a sectional view taken along a longitudinal axis of a
• Figure 2 is a sectional view taken along a longitudinal axis of a
• Figure 3 is a perpendicular to the sectional view of Figure 2 standing
• Figure 4 is a perspective view of a switching element and a
• Figure 5 is a sectional view of a portion of a Inj edictionsvortechnische in one
• FIG. 6 shows a sectional view of the part of the injection device from FIG. 5 after product dispensing
• FIG. 7 shows a sectional view of a switching element and a triggering element in an initial position
• FIG. 8 shows a sectional view of the switching element and the triggering element
• Figure 7 in a coupling position
• Figure 9 is a sectional view of the switching element and the trigger element of the
• Figures 7 and 8 in a release position and Figure 10 is an exploded view with a feed element, a
• Locking element and a means of elasticity Locking element and a means of elasticity.
• FIG. 1 shows an injection device in the form of an auto-injector.
• the injection device comprises a mechanism, with a mechanical sequence control, with a contained in the Inj edictionsvorraum product container 21 is first displaced during a puncture sequence in the distal direction, so that the attached to the product container 21 needle 22 in a body tissue of a patient is plunged, wherein after the plunge sequence during a Aus thoroughlysequenz the piston 20 is moved in the product container 21 in the distal direction, so that the product contained in the container 21 is released by the needle 22 into the body or the body tissue of a patient.
• FIG. 1 relates in particular also to FIGS. 2 and 3, in which a similar injection device, in particular without a product container 21, is shown.
• the injection device comprises a distal housing part 25 and a proximal housing part 24, which are connected to a detachable connection, in particular a bayonet closure 23.
• a mechanism holder 5 is received, which is rotatably and axially fixed to the proximal housing part 24 is connected.
• this is surrounded with its end faces axially between a radially inwardly projecting projection of the housing 24 and a proximal to the housing 24 plugged cap 26.
• the mechanism holder 5 surrounds a feed element 6, which is displaceable relative to the mechanism holder 5 along the longitudinal axis L of the injection device.
• the sleeve-shaped feed element 6 can slide with its outer peripheral surface on the inner peripheral surface of the approximately sleeve-shaped mechanism holder 5 along. Between a distal end face of the mechanism holder 5 and a proximal end face of an annular flange arranged at the distal end of the feed element 6, a spring 10, in particular a helical spring 10 is arranged, which in a pressure-biased state, the feed element 6 relative to the mechanism holder 5 in the distal direction acted upon by a feed force.
• the distal end surface of the annular flange mounted distally on the advancing element 6 can act in a direction along the longitudinal axis L on a cage 17, which is displaceable along the longitudinal axis L in the housing 24, 25.
• the cage 17 is coupled to the product container 21 so that upon movement of the cage 17 in the distal direction, the product container 21 is also moved in the distal direction, namely in Einstechiques the needle 22.
• movement of the cage 10 in the distal direction movement of the piston 20 within the product container 21 can not be caused.
• a biased pressure spring 27 By means of a biased pressure spring 27 the "product container 21 and the cage 17 are pressed in the proximal direction of the injection device.
• the force of the spring 27 with which the cage 17 is pressed in the proximal direction is smaller than the force of the spring 10 with which the advancing element 6 and the cage 17 can be moved in the distal direction when the advancing element 6 for movement along the longitudinal axis L. is released, so that the product container 21 can be moved with the needle 22 in the distal direction for piercing the needle 22 in the body tissue.
• a tubular output member 9 is arranged, which can be moved for a Aus thoroughlysequenz relative to the advancing element 6 along the longitudinal axis L, when it is released for axial movement.
• a radially outwardly projecting collar 92 At the proximal end of the output member 9 is a radially outwardly projecting collar 92.
• an annular groove Between the output member 9 and the feed element 6 is an annular groove whose groove width is greater than the amount that the collar 92 projects radially from the output member 9.
• the cage 17 engages with a sleeve-shaped portion from the distal side into the inner diameter of the advancing element 9, as best seen in FIG.
• the distal end of the output member 9 has an end face 91 which acts as a stop surface and against which a spring 15, in particular a helical spring, can be supported.
• the pressure-biasable spring 15 is supported at its other end on a distal surface of a stopper member 64 which is formed at a proximal portion of the advancing member 6.
• the spring 15, which in particular has a greater spring constant than the spring 10, can drive the released output member 9 in the distal direction along the longitudinal axis L.
• the locking element 7 is, as can be seen in Figure 10, forked and engages around the longitudinal axis L with two locking portions 71.
• the locking portions 71 are each guided in a groove-shaped guide 67 ( Figure 10), which is formed by the feed element 6.
• the locking element 7 is also guided by a stop element 64 accommodated between the locking sections 71 and formed by the advancing element 6. Between the proximal end face of the stop element 64 and a distal end face of the locking element 7, as shown for example in FIG. 5, there can be a distance d about which the locking element 7 can be moved in the distal direction.
• the locking element 7 can be seen in particular in Figure 10
• the spring 8 is supported on the proximal end of the locking element 7 and on a feed element-fixed element arranged proximally thereof, namely on the retaining web 81.
• the retaining web 81 can be introduced through openings forming a Garstegaufhahme 66, transverse to the longitudinal axis L in the advancing member 6 and secured thereto to serve as an abutment for the spring 8.
• the spring 8 may be, for example, a helical or combined helical and spiral spring or a leaf spring.
• the retaining web 81 may be made of a spring material and have a shape that can act directly on the locking element 7 with a spring force, so that the spring 8 can be omitted because the locking element 7 takes over the task of the spring 8.
• a movement of the locking element 7 in the distal direction is prevented, in particular by blocking the locking element 7, in particular with its locking sections 71, by a respective gear surface 65 of a locking element 62.
• the cam-shaped blocking element 62 is arranged on an arm 61 and, for example, integrally connected in a resilient manner to the advancing element 6.
• the gear surface 65 also serves in the position shown in Figure 5 for blocking the longitudinal movement of the output member 9.
• the output member 9 is at its collar 92 on the gear surface 65 at.
• the locking element 7 can either directly on the Gear surface 65 or at a proximal portion of the collar 92 pending.
• the blocking element 62 comes after a certain distance, which preferably corresponds approximately to the path by which the product container 21 is moved to pierce, approximately at the same axial height as a locking groove 53 Locking groove 53 is formed by the feed element 6.
• the locking groove 53 may be a recess or an annular circumferential recess for the locking elements 62.
• the locking groove 53 and the locking member 62 are at an axially equal height, due to the spring force of the arms 61 and / or the spring force of the spring 8 and / or due to the spring force of the spring 15 in conjunction with the sliding of the collar 92 and / or the locking element 7 on the gear surface 65 of the locking element 62 moves radially outwardly into the locking groove 53. This starts the ejection sequence.
• the collar 92 is then no longer blocked by the gear surface 65, whereby the spring 15 drives the output member 9 in the distal direction and thus the piston 20 for a product distribution.
• the locking element 7 is released for axial movement, so that the spring 8 displaces the locking element 7 by the distance d (FIG. 5), as a result of which the locking sections 71 slide in front of the blocking elements 62.
• a movement of the locking member 62 from the locking groove 53 is prevented because the locking portion 71, the movement that would cause the locking member 62 in a movement out of the locking groove 53 blocks.
• the movement of the output member 9 can be limited to a path z (FIG. 4), wherein the sleeve-shaped portion of the cage 17 forms the end stop, or to a distance that the piston 20 can travel in the product container 21.
• the dispensing movement of the output member 9 can not take place until the needle 22 has completed its piercing movement. It is further preferred that the puncture sequence can be started only when designed as a needle cover transfer element 2 is pressed sufficiently firmly at the puncture site on the body tissue.
• the transmission member 2 is displaced relative to the distal housing part 25. From the proximal housing part 24, a switching element 1 along the Longitudinal axis L movably mounted. As shown in Figures 7 to 9, the switching element 1 is carried along by the movement of the transfer member 2 in the proximal direction.
• a proximal end face of the transmission member 2 and a distal end face of the switching element 1 get into a stop.
• the transmission member 2 is moved against the force of a spring in the proximal direction.
• the switching element 1 is pressed by a spring 18 in the distal direction.
• the switching element 1 can be moved against the force of the spring 18 in the proximal direction.
• the switching element 1 has an annular portion which cooperates as an axial stop for a movement in the distal direction of the switching element 1 with the mechanism holder 5 when the switching element 1 is in its initial position.
• the switching element 1 has a control surface element 4, which has a control surface 41 which is inclined relative to the longitudinal axis L. As shown in particular in Figure 4, the switching element 1 is forked. At each of the two fork elements is a control surface element 4.
• a trigger element 3, which is also forked, has at each of its fork elements on a cam 33 which can cooperate with the respective control surface element 4.
• the trigger element 3 is transversely, in particular, as shown herein, perpendicular to the longitudinal axis L movable.
• the cams 33 and the control surface elements 4 are each arranged at a distance from a plane which is spanned by the longitudinal axis L and the direction of movement of the triggering element 3.
• the fork elements of the switching element 1 and the trigger element 3 engage around the longitudinal axis L.
• an initial position of the switching element 1 is shown.
• the triggering element 3 is pressed by a resilient element, in particular a spring (not shown) with the cam 33 against the control surface 41 of the control surface element 4.
• an actuating element 31 connected to the triggering element 3 assumes a position below or flush with the level of the housing 24, 25, as shown for example in FIG. 6, the position shown in FIG. 6 being only an example.
• the actuating element 31 can not or can not easily be actuated, for example, with a finger of the user.
• An actuation of the actuating element 31 in the starting position shown in Figure 7 or in an intermediate position between Starting position and coupling position of the switching element 1 leads to no triggering of the sequence control for the injection.
• the control surface 41 which is inclined in relation to the longitudinal axis L, slides along the cam 33, whereby the triggering element 3 is initially displaced transversely to the longitudinal axis L, so that the actuating element 31 rises above the level of the housing 25.
• the user can, for example, gain access to the actuating element 31 or an optical indication for the readiness of the device for triggering the sequence control, so that he can actuate the triggering element 3 later in the process.
• a control surface 42 travels along the cam 33 in a further movement of the switching element 1 in the proximal direction, the control surface 42 being approximately parallel to the longitudinal axis L, as shown in this example, such that upon movement of the control surface 42 along the cam 33, the trigger element 3 is stationary.
• the switching element has reached the coupling position shown in Figure 8, the trigger element 3 and the actuator 31 is operable for effective triggering of the flow control.
• the actuator 31 is pressed transversely to the longitudinal axis L, then the control surface 32 of the trigger member 3 slides on the cam member 4, whereby the switching element 1 is moved by a distance X 3 in the proximal direction, so that it occupies a release position. In the release position, the sequence control of the injection device is set in motion.
• the mechanism holder 4 has a locking member 52, which is arranged so as to be resilient via an arm 51 and which engages in a latching groove 63 which is located on the outer circumference of the feed element 6. As long as the locking member 52 engages in the locking groove 63, a movement of the feed element 6 is blocked relative to the mechanism holder 5.
• a holding stage 11 which is formed by the switching element 1, at the axial height with the locking member 52, so that the locking member 52 of the holding stage 11 in engagement with the advancing element. 6 is held.
• a release step 12 formed by the switching element 1 is brought to axial height with the locking member 52, which due to the resilient arm 51 and / or due to the transmission effect of the applied with an axial force of the spring 10 Feed element 6 and the geometry of the locking member 52, the locking member 52 is pressed out of engagement with the locking groove 63.
• the distance from the holding stage 11 to the longitudinal axis L is less than the distance of the release stage 12 to the longitudinal axis L.
• mounting brackets 13 are arranged on the switching element 1, at which during assembly of the switching element 1 with the mechanism holder. 5 the locking members 52 are guided to the support levels 12.

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• Health & Medical Sciences (AREA)
• Vascular Medicine (AREA)
• Engineering & Computer Science (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)
• Fuel-Injection Apparatus (AREA)

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• 2005
  • 2005-11-03 DE DE102005052502A patent/DE102005052502A1/de not_active Withdrawn
• 2006
  • 2006-10-31 CN CNA2006800504011A patent/CN101355977A/zh active Pending
  • 2006-10-31 JP JP2008538242A patent/JP2009514572A/ja not_active Withdrawn
  • 2006-10-31 AU AU2006310971A patent/AU2006310971B2/en not_active Ceased
  • 2006-10-31 WO PCT/CH2006/000603 patent/WO2007051330A1/de active Application Filing
  • 2006-10-31 EP EP06804837A patent/EP1945286A1/de not_active Withdrawn
• 2008
  • 2008-05-01 US US12/113,597 patent/US20080262427A1/en not_active Abandoned

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