EP1846165A2 - Maldi-chiphalter - Google Patents
Maldi-chiphalterInfo
- Publication number
- EP1846165A2 EP1846165A2 EP06707939A EP06707939A EP1846165A2 EP 1846165 A2 EP1846165 A2 EP 1846165A2 EP 06707939 A EP06707939 A EP 06707939A EP 06707939 A EP06707939 A EP 06707939A EP 1846165 A2 EP1846165 A2 EP 1846165A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- maldi
- holder
- maldi chip
- holder according
- chip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0409—Sample holders or containers
- H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
Definitions
- the present invention relates to a holder for a MALDI chip, which has a broken corner contour, with a first and a second respectively chamfered contact surface and a movable fixing means, which cooperates with the broken corner contour and biases the MALDI chip against the contact surfaces. Furthermore, the present invention relates to a MALDI chip and a system consisting of the holder and the MALDI chip.
- mass spectrometry For the analysis of samples, for example in drug chemistry or in biological research and production, mass spectrometry has become increasingly popular. For the analysis of biomolecules in the samples, mass spectrometry with ionization by matrix-assisted laser desorption and ionization (MALDI) is preferably used.
- MALDI matrix-assisted laser desorption and ionization
- MALDI in particular biomolecules and / or biological material in the form of a liquid drop are metered onto a so-called MALDI matrix point, for example pipetted, and dried.
- the resulting crystals are analyzed, for example, with a MALDI-TOF mass spectrometer in linear or in reflector operation. Details of this procedure can Nordhoff et. al. "MALDI-MS as a new method for the analysis of nucleic acid (DNA and RNA) with molecular mass up to 150,000 Dalton, Application of modern mass spectrometric methods to plan science research, Oxford University Press, (1996) page 86-101 which is hereby incorporated by reference and thus forms part of the disclosure.
- MALDI chip - In the MALDI method, in some cases more than 200 MALDI matrix points are applied to a sample carrier - referred to below as a MALDI chip - which then has to be analyzed. It will be understood by those skilled in the art that both the application of the samples and the later analysis, due to the plurality of MALDI matrix points arranged in a comparatively small space, requires very high precision and very precise positioning of the MALDI chip. It was therefore the object of the present innovation to provide a holder on which a MALDI chip can be positioned very accurately and reproducibly.
- a MALDI chip can be positioned very precisely and reproducibly with the holder according to the invention, so that the metering of the substances to be analyzed and / or the subsequent analyzes can be carried out very precisely.
- the holder according to the invention is simple and inexpensive to manufacture and use. Even deposits on the holder do not affect the exact position of the MALDI chips.
- the holder has a first and a second contact surface, which are preferably arranged at right angles to one another and against which the MALDI chip rests. Furthermore, the holder according to the invention has a fixing means with which the MALDI chip can be fixed in contact with the contact surfaces. According to the MALDI chip is biased by the fixing means against the contact surfaces. This has the advantage that even with mechanical influences such as vibrations or temperature influences, the MALDI chip is permanently in contact with the first and the second contact surface, so that its position in a plane is at least clearly defined. Furthermore, according to the invention, the fixing agent cooperates with the broken corner contour.
- the holder has a bearing surface on which rests the MALDI chip.
- the contact surfaces of the holder according to the invention are chamfered so that the MALDI chip, in particular, when biased, is biased against the support.
- the fixative is a slider.
- this slider has a spring which biases him in the direction of the contact surfaces.
- At least one contact surface of the holder is at least partially coated with a highly electrically conductive material, which is particularly preferably not corroded.
- the material is gold.
- the support surface has a recess, in particular a bore. This hole facilitates removal of the MALDI chip after analysis.
- one or more spring means is arranged on the opposite side of the support surface of the holder, with which the holder relative to the analyzer is biased.
- Another object of the present invention is a Maldi chip having a gold-plated edge region.
- FIG. 1 schematically shows a MALDI chip.
- FIG. 3 shows a section through the holder according to the invention.
- FIG. 4 shows the slider of the holder according to the invention in interaction with the lever.
- FIG. 1 shows a MALDI chip 6, which has a plurality of points 12, to which a MALDI matrix can be dosed.
- the MALDI chip has its upper left Corner a flattened corner contour 8, wherein the skilled artisan recognizes that the corner contour can also be designed differently.
- FIG. 2a shows the holder 1 according to the invention in the MALDI chip fixing state, the MALDI chip has been omitted for illustrative purposes.
- the holder 1 has a first and a second contact surface 2, 3, on which the MALDI chip 6 (not shown in this figure) is applied. Between the contact surfaces 2, 3, a recess 10 is arranged, which is required for a processing of the contact surfaces 2, 3, but also prevents the MALDI chip is applied only at its corner.
- the holder according to the invention has a support surface 5, on which the MALDI chip 6 rests.
- the slide 4 which is movable according to the directions indicated by the double arrow 9 and which is biased by a spring (not shown) in the direction of the contact surfaces 2.3, the MALDI chip is pressed against the contact surfaces 2.3.
- the upper diagram shows the slider from above, ie from the side on which the MALDI chip rests.
- the slider 4 is located in its front, i.e. in a position fixing the MALDI chip.
- the recess 15 can be seen in the support surface 5, which is covered in the MALDI chip fixing state from the rear of the lever 14.
- the bottom view shows the holder 1 from below.
- FIG. 2b shows the holder according to FIG. 2a in the rear unlocking position of the slider, in which the MALDI chip can be removed or a new MALDI chip can be inserted into the holder.
- the lever 14 is arranged in this position substantially perpendicular to the holder and thereby releases the opening 15. Furthermore, the locking of the slider 4 is released by the lever.
- FIG. 3 shows the MALDI chip 6 in its exactly fixed position.
- the abutment surfaces 2, 3 are chamfered, so that the Spring force of the fixing means 4 to the contact surfaces 2.3 also induces a downward, symbolized by the arrow 1 1 movement, with which the MALDI chip 6 is permanently held in contact with the support surface 5, thereby ensuring that the MALDI chip 6 is also spatially clearly positioned on the holder.
- FIG. 4 shows the slider of the holder according to the invention, which has a contact surface 7 which corresponds to the corner contour 8 of the MALDI chip 6. Also, the contact surface 7 is chamfered, so that the MALDI chip is also pressed by this surface against the support surface.
- the lever 14, which is shown here in the locking position, does not touch the slider 4 in this position. The slider 4 has contact in this position with the corner contour 8 of the MALDI chip 6 and presses it against the contact surfaces 2, 3.
- FIG. 5 shows how a MALDI chip is inserted into the holder according to the invention.
- the slider 4 is first moved to the bottom right and locked in this position. Thereafter, the MALDI chip is inserted into the holder so that the flattened corner contour 8 points in the direction of the slider.
- the slider is folded over and presses due to the force of the existing spring (not shown) the MALDI chip in the upper left corner that it rests against the contact surfaces 2, 3.
- Figure 6 shows the underside of the holder, the leaf springs 13 which bias the holder against the analyzer and ensure good electrical contact with the analyzer.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Electron Beam Exposure (AREA)
- Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200520001641 DE202005001641U1 (de) | 2005-02-01 | 2005-02-01 | MALDI-Chiphalter |
PCT/EP2006/050573 WO2006082193A2 (de) | 2005-02-01 | 2006-01-31 | Maldi-chiphalter |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1846165A2 true EP1846165A2 (de) | 2007-10-24 |
EP1846165B1 EP1846165B1 (de) | 2013-05-22 |
Family
ID=34707023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06707939.2A Not-in-force EP1846165B1 (de) | 2005-02-01 | 2006-01-31 | Maldi-chiphalter |
Country Status (4)
Country | Link |
---|---|
US (1) | US20090212233A1 (de) |
EP (1) | EP1846165B1 (de) |
DE (1) | DE202005001641U1 (de) |
WO (1) | WO2006082193A2 (de) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4159875A (en) * | 1976-10-21 | 1979-07-03 | Abbott Laboratories | Specimen holder |
US5592289A (en) * | 1995-01-09 | 1997-01-07 | Molecular Dynamics | Self-aligning mechanism for positioning analyte receptacles |
ATE334397T1 (de) * | 1999-12-21 | 2006-08-15 | Tecan Trading Ag | Klemmvorrichtung zur aufnahme und genauer positionierung eines gegenstandes, vorzüglich einer mikrotiterplatte, sowie verfahren zu ihrem betrieb |
AU7131701A (en) * | 2000-06-15 | 2001-12-24 | Irm Llc | Automated precision object holder |
KR20040105360A (ko) * | 2003-06-07 | 2004-12-16 | 삼성전자주식회사 | 레이저 탈착/이온화 질량 분석용 시료 홀더 및 그 제조방법 |
US6825478B1 (en) * | 2003-10-10 | 2004-11-30 | Perseptive Biosystems, Inc. | MALDI plate with removable magnetic insert |
-
2005
- 2005-02-01 DE DE200520001641 patent/DE202005001641U1/de not_active Expired - Lifetime
-
2006
- 2006-01-31 US US11/814,837 patent/US20090212233A1/en not_active Abandoned
- 2006-01-31 WO PCT/EP2006/050573 patent/WO2006082193A2/de active Application Filing
- 2006-01-31 EP EP06707939.2A patent/EP1846165B1/de not_active Not-in-force
Non-Patent Citations (1)
Title |
---|
See references of WO2006082193A2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006082193A2 (de) | 2006-08-10 |
DE202005001641U1 (de) | 2005-06-23 |
WO2006082193A3 (de) | 2007-03-22 |
EP1846165B1 (de) | 2013-05-22 |
US20090212233A1 (en) | 2009-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3235061B1 (de) | Elektrische anschlussklemme | |
EP3627625A1 (de) | Verbindungsklemme | |
EP3595091B1 (de) | Leiteranschlussklemme und set aus leiteranschlussklemme und betätigungswerkzeug | |
EP2316150A1 (de) | Elektrische anschlussklemme | |
WO2009100910A1 (de) | Vorrichtung und verfahren zum ausrichten und halten einer mehrzahl singulierter halbleiterbauelemente in aufnahmetaschen eines klemmträgers | |
DE202007001701U1 (de) | Universalkontakt | |
DE102005037024A1 (de) | Sockelanordnung zum Testen einer Halbleitervorrichtung | |
DE202017105467U1 (de) | Leiteranschlussklemme | |
EP1074030B1 (de) | Schaltgerät mit einer schaltkammer-baugruppe | |
EP3005484A1 (de) | Anschluss- oder verbindungsklemme | |
DE102007017059B4 (de) | Sockel für elektrische Bauteile | |
EP1846165B1 (de) | Maldi-chiphalter | |
EP1623483B1 (de) | Kontaktierungsvorrichtung für flexible flachbandleiter | |
EP0433688A1 (de) | Vorrichtung zum elektrischen Kontaktieren einer längs einer ihrer Seiten Anschlusspole aufweisenden, elektronischen Karte, insbesondere IC-Memory-Karte, mit einer Basisleiterplatte | |
DE3319972C2 (de) | ||
DE3001120C2 (de) | Spitzbohrwerkzeug mit auswechselbarem Bohrmesser | |
DE102018124622B3 (de) | Kontakteinsatz, damit gebildete Anordnung, Leiteranschlussklemme sowie Verfahren zur Bereitstellung des Kontakteinsatzes | |
DE19906422C2 (de) | Halter für Objektträger | |
EP1243078B1 (de) | Elektrisches gerät mit einem gehäuse | |
WO2002013316A1 (de) | Anschlusselement und verfahren zum werkzeuglosen elektrischen kontaktieren einer elektrischen ader | |
DE102005051312A1 (de) | Fassung für elektrische Teile | |
DE10216208C1 (de) | Berührungsschutzvorrichtung für eine elektrische Steckdose | |
DE10252106A1 (de) | Schnappverschließvorrichtung für einen KGD-Träger | |
EP4358310A1 (de) | Anschlussklemme zum anschliessen einer elektrischen leitung | |
DE102022127539A1 (de) | Anschlussklemme zum Anschließen einer elektrischen Leitung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK YU |
|
17P | Request for examination filed |
Effective date: 20070924 |
|
RBV | Designated contracting states (corrected) |
Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20091008 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 612912 Country of ref document: AT Kind code of ref document: T Effective date: 20130615 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 502006012878 Country of ref document: DE Effective date: 20130718 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130923 Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130922 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130902 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130823 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: VDEP Effective date: 20130522 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130822 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20140225 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 502006012878 Country of ref document: DE Effective date: 20140225 |
|
BERE | Be: lapsed |
Owner name: QIAGEN G.M.B.H. Effective date: 20140131 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 Ref country code: LU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20140131 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140131 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140131 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140131 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140131 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 612912 Country of ref document: AT Kind code of ref document: T Effective date: 20140131 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140131 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 11 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20060131 Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20130522 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 12 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20180119 Year of fee payment: 13 Ref country code: DE Payment date: 20180122 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20180119 Year of fee payment: 13 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 502006012878 Country of ref document: DE |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20190131 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190131 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190801 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190131 |