EP1800691A3 - Compositions et procédés permettant la prévention ou le traitement du cancer et de la perte osseuse associée au cancer - Google Patents

Compositions et procédés permettant la prévention ou le traitement du cancer et de la perte osseuse associée au cancer Download PDF

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Publication number
EP1800691A3
EP1800691A3 EP06022155A EP06022155A EP1800691A3 EP 1800691 A3 EP1800691 A3 EP 1800691A3 EP 06022155 A EP06022155 A EP 06022155A EP 06022155 A EP06022155 A EP 06022155A EP 1800691 A3 EP1800691 A3 EP 1800691A3
Authority
EP
European Patent Office
Prior art keywords
cancer
compositions
treatment
prevention
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06022155A
Other languages
German (de)
English (en)
Other versions
EP1800691A2 (fr
Inventor
Colin R. Dunstan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of EP1800691A2 publication Critical patent/EP1800691A2/fr
Publication of EP1800691A3 publication Critical patent/EP1800691A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP06022155A 1999-09-03 2000-08-18 Compositions et procédés permettant la prévention ou le traitement du cancer et de la perte osseuse associée au cancer Withdrawn EP1800691A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38954599A 1999-09-03 1999-09-03
EP00955737A EP1140136B1 (fr) 1999-09-03 2000-08-18 Compositions et procedes permettant la prevention ou le traitement du cancer et de la perte osseuse associee au cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP00955737A Division EP1140136B1 (fr) 1999-09-03 2000-08-18 Compositions et procedes permettant la prevention ou le traitement du cancer et de la perte osseuse associee au cancer

Publications (2)

Publication Number Publication Date
EP1800691A2 EP1800691A2 (fr) 2007-06-27
EP1800691A3 true EP1800691A3 (fr) 2007-10-31

Family

ID=23538715

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06022155A Withdrawn EP1800691A3 (fr) 1999-09-03 2000-08-18 Compositions et procédés permettant la prévention ou le traitement du cancer et de la perte osseuse associée au cancer
EP00955737A Expired - Lifetime EP1140136B1 (fr) 1999-09-03 2000-08-18 Compositions et procedes permettant la prevention ou le traitement du cancer et de la perte osseuse associee au cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP00955737A Expired - Lifetime EP1140136B1 (fr) 1999-09-03 2000-08-18 Compositions et procedes permettant la prevention ou le traitement du cancer et de la perte osseuse associee au cancer

Country Status (14)

Country Link
US (1) US20060019887A1 (fr)
EP (2) EP1800691A3 (fr)
JP (2) JP2003508491A (fr)
KR (1) KR20010085996A (fr)
CN (1) CN1345246A (fr)
AT (1) ATE362374T1 (fr)
AU (1) AU6788900A (fr)
CA (1) CA2349406C (fr)
DE (1) DE60034871T2 (fr)
ES (1) ES2287028T3 (fr)
HU (1) HUP0104688A3 (fr)
IL (1) IL142900A0 (fr)
WO (1) WO2001017543A2 (fr)
ZA (1) ZA200103565B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
DE69740107D1 (de) 1996-12-23 2011-03-10 Immunex Corp Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie
NZ332995A (en) 1997-04-15 2000-07-28 Snow Brand Milk Products Co Ltd A protein which binds to osteoclastogenesis inhibitory factor (OCIF)
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
ATE363533T1 (de) 1997-04-16 2007-06-15 Amgen Inc Osteoprotegerin bindende proteine und rezeptoren
AU762574B2 (en) 1998-05-14 2003-06-26 Immunex Corporation Method of inhibiting osteoclast activity
NZ511506A (en) 1998-10-28 2004-02-27 Sankyo Co Remedies for bone metabolic errors comprising OCIF
US20020090646A1 (en) * 2000-05-03 2002-07-11 Amgen Inc. Calcitonin-related molecules
DE01973455T1 (de) 2000-09-22 2004-04-22 Immunex Corp., Seattle Screeningverfahren für agonisten und antagonisten des rezeptoraktivators von nf-kappa b
JP2005515159A (ja) * 2001-06-06 2005-05-26 イミュネックス・コーポレーション 癌を治療するためのｒａｎｋアンタゴニストの使用
EP1270015A3 (fr) * 2001-06-29 2004-02-25 Sankyo Company Limited Un complexe de OCIF et de polysaccharide
MXPA04009681A (es) 2002-04-05 2005-01-11 Amgen Inc Anticuerpos humanos neutralizantes anti-ligando de osteoprotegerina como inhibidores selectivos de la ruta del ligando de osteoprotegerina.
US7638480B2 (en) * 2002-04-10 2009-12-29 Laboratoires Serono Sa Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
US7585840B2 (en) 2002-04-10 2009-09-08 Merck Serono S.A. Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
AU2003233721B2 (en) * 2002-06-07 2009-07-02 Trillium Therapeutics Inc. CD200-receptor mediated modulation of bone development
ZA200704473B (en) 2004-12-13 2008-09-25 Evogenix Ltd Osteoprotegerin variant proteins
TW200714289A (en) * 2005-02-28 2007-04-16 Genentech Inc Treatment of bone disorders
DK2442650T3 (en) * 2009-06-12 2015-12-07 Cynapsus Therapeutics Inc sublingual apomorphine
CN102242209B (zh) * 2011-07-05 2013-12-11 北京大学人民医院 基于多个基因辅助诊断多发性骨髓瘤患者的定量检测试剂盒
EA034861B1 (ru) * 2012-03-31 2020-03-30 Р-Фарм Интернешнл, Ооо (Общество С Ограниченной Ответственностью) Композиция, полученная из остеопротегерина, и способ ее использования
US20170073391A1 (en) * 2014-03-06 2017-03-16 R-Pharm Overseas, Inc. Osteoprotegerin derived RANKL inhibitor
KR101576904B1 (ko) * 2014-07-31 2015-12-14 (주)케어젠 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도
JP2020500306A (ja) * 2016-11-04 2020-01-09 オーフス ウニベルシテット 新生児Ｆｃ受容体の過剰発現により特徴づけられる腫瘍の同定と治療
CN110483647B (zh) * 2019-08-19 2021-02-09 重庆大学附属肿瘤医院 一种抗肿瘤多肽及其应用

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0784093A1 (fr) * 1995-12-22 1997-07-16 Amgen Inc. Ostéoprotégerin
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides

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US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
AU610083B2 (en) * 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
FR2640537B1 (fr) * 1988-12-21 1992-02-21 Levy Guy Installation et procede utilisant l'effet laser, pour la coupe ou la vaporisation de materiaux et tissus divers
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
AU643141B2 (en) * 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
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US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
EP0784093A1 (fr) * 1995-12-22 1997-07-16 Amgen Inc. Ostéoprotégerin

Non-Patent Citations (4)

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Title
MORONY S ET AL: "A CHIMERIC FORM OF OSTEOPROTEGERIN INHIBITS HYPERCALCEMIA AND BONE RESORPTION INDUCED BY IL-1BETA, TNF-ALPHA, PTH, PTHRP, AND 1,25(OH)2D3", JOURNAL OF BONE AND MINERAL RESEARCH,NEW YORK, NY,US, vol. 14, no. 9, September 1999 (1999-09-01), pages 1478 - 1485, XP000971493, ISSN: 0884-0431 *
PERIGAUD C ET AL: "NUCLEOSIDE ANALOGUES AS CHEMOTHERAPEUTIC AGENTS: A REVIEW", NUCLEOSIDES & NUCLEOTIDES,US,DEKKER, NEW YORK,NY,, vol. 11, no. 2/04, 1992, pages 903 - 945, XP000607988, ISSN: 0732-8311 *
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Also Published As

Publication number Publication date
EP1140136B1 (fr) 2007-05-16
WO2001017543A2 (fr) 2001-03-15
ZA200103565B (en) 2002-05-03
HUP0104688A3 (en) 2004-07-28
EP1800691A2 (fr) 2007-06-27
KR20010085996A (ko) 2001-09-07
HUP0104688A2 (hu) 2002-03-28
AU6788900A (en) 2001-04-10
DE60034871T2 (de) 2008-01-17
ATE362374T1 (de) 2007-06-15
IL142900A0 (en) 2002-04-21
US20060019887A1 (en) 2006-01-26
CA2349406C (fr) 2011-01-11
EP1140136A2 (fr) 2001-10-10
DE60034871D1 (de) 2007-06-28
WO2001017543A3 (fr) 2001-07-26
JP2011225581A (ja) 2011-11-10
ES2287028T3 (es) 2007-12-16
JP2003508491A (ja) 2003-03-04
CN1345246A (zh) 2002-04-17
CA2349406A1 (fr) 2001-03-15

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