EP1732848A1 - Complexes basiques d'halogenure d'aluminium - Google Patents

Complexes basiques d'halogenure d'aluminium

Info

Publication number
EP1732848A1
EP1732848A1 EP05728684A EP05728684A EP1732848A1 EP 1732848 A1 EP1732848 A1 EP 1732848A1 EP 05728684 A EP05728684 A EP 05728684A EP 05728684 A EP05728684 A EP 05728684A EP 1732848 A1 EP1732848 A1 EP 1732848A1
Authority
EP
European Patent Office
Prior art keywords
acid
aluminum
basic
organic acid
hydrohalic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05728684A
Other languages
German (de)
English (en)
Inventor
Norbert Roesch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clariant Produkte Deutschland GmbH
Original Assignee
Clariant Produkte Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant Produkte Deutschland GmbH filed Critical Clariant Produkte Deutschland GmbH
Publication of EP1732848A1 publication Critical patent/EP1732848A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F7/00—Compounds of aluminium
    • C01F7/48—Halides, with or without other cations besides aluminium
    • C01F7/64—Bromides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F7/00—Compounds of aluminium
    • C01F7/48—Halides, with or without other cations besides aluminium
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F7/00—Compounds of aluminium
    • C01F7/48—Halides, with or without other cations besides aluminium
    • C01F7/56—Chlorides
    • C01F7/57—Basic aluminium chlorides, e.g. polyaluminium chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/87—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by chromatography data, e.g. HPLC, gas chromatography

Definitions

  • Basic aluminum halides in the form of chlorides are used as an active ingredient in cosmetic preparations such as antiperspirants or astringents.
  • the far better-acting aluminum chloride hexahydrate is ruled out for this application because of its skin-irritating effect. It is used for therapeutic purposes in the presence of hyperhidrosis (sweating sickness).
  • the difference between the aluminum chlorides mentioned is that the basic salts form oligomeric and polymeric aluminum species (see S. Schönherr, H. Görz, D. Müller and W. Gessner; in Z.anorg.allg. Chem. 476, 188-194 (1991)), which show a reduced effectiveness in antiperspirants.
  • Another way to present more effective antiperspirant active ingredients is the use of mixed compounds which consist of combinations of basic aluminum halides (preferably chlorides), zirconium salts and glycine.
  • Various manufacturing methods are described in US 4,871,525; Find US 4775 528 and DE 25 37359.
  • a further increase in the effectiveness of the zirconium-aluminum mixed salts is described in EP 0 653 203; WO 02/34223; WO 0234223; EP 0 455489 and EP 0 444564.
  • the disadvantage of zirconium aluminum salts is the high price for the available zirconium raw materials.
  • EP 1 364 651 describes the use of a mixture of basic aluminum hydrate and trivalent aluminum salts which contain organic ligands for the production of pharmaceutical preparations which have a skin-swelling effect. Use as an antiperspirant active ingredient is neither described there, nor can such an antiperspirant effect be derived for the person skilled in the art from this document.
  • the Na salt of a complex of lactic acid and aluminum chlorohydrate (Choracel) and its effect as a cosmetic astringent is known.
  • this product is not a real aluminum-lactic acid complex, but a mixture of aluminum chlorohydrate and lactic acid.
  • the object of the present invention is to improve the effectiveness of basic aluminum chlorides as an antiperspirant active ingredient by reducing the formation of polymeric aluminum structures. This problem was solved by the incorporation of organic acids as complex ligands in the basic aluminum halides.
  • the invention relates to basic aluminum halide complexes obtained by reacting aluminum metal with hydrohalic acid and an organic acid, either dissolving the aluminum metal in a mixture of hydrohalic acid and organic acid or the Aluminum metal first dissolves in the hydrohalic acid and then the organic acid is added.
  • the first variant ie the dissolution of the aluminum metal in the mixture of hydrohalic acid and organic acid, is preferred.
  • HBr but in particular HCl in the form of its aqueous solution, can be used as the hydrogen halide.
  • concentration of the hydrohalic acid is preferably 1 to 10% by weight, preferably 5% by weight.
  • Suitable organic acids are in particular those which contain 1 to 5 carbon atoms. These organic acids can be mono-, di- or tricarboxylic acids, but aminocarboxylic acids or hydroxycarboxylic acids are also possible, the latter being preferred. Examples of such acids are glycolic acid, lactic acid, tartronic acid, tartaric acid, malic acid and glycine.
  • the ratio of hydrohalic acid to organic acid can be between 10 to 90 mol% for each of the two acids.
  • a mixture of 20 to 50 mol% of hydrohalic acid and 50 to 80 mol% of organic acid is preferred.
  • the concentration of the hydrohalic acid is as stated above.
  • the aluminum metal is then dissolved in this acid mixture.
  • the aluminum metal can be in the form of powder, grit, granules or as bars.
  • the reaction is preferably carried out at temperatures from 20 to 100 ° C., preferably at 50 to 100 ° C. The reaction runs until the desired atomic ratio of Al to halogen or to the anion of the organic acid has been established in the reaction solution.
  • the aqueous solution of the basic aluminum halide thus obtained can be used directly as an antiperspirant active ingredient.
  • hydrohalic acid and / or organic acid after the reaction between aluminum metal and the acid mixture.
  • hydrohalic acid and / or organic acid after the reaction between aluminum metal and the acid mixture.
  • ⁇ -amino acids for example glycine, are suitable as buffer substances.
  • the aqueous solutions of the basic aluminum complexes obtained in this way are distinguished by the fact that the proportions of Al polymer are significantly reduced, while at the same time the proportion of Al monomers and Al oligomers increases. These solutions can be processed directly as an antiperspirant active ingredient.
  • these basic aluminum complexes according to the invention can also be mixed with other customary antiperspirant active ingredients, for example with Al-zirconium-glycine-chloro complexes or other metal complexes which contain Zr, Hf, Ti or Sn.
  • a buffer substance for example an amino acid such as glycine, in order to set a pH of 4-5.
  • Example 1 The aluminum complex prepared in Example 1 was mixed with hydrochloric acid, water and glycine to obtain the composition shown in Table 1.
  • Example 2 The aluminum complex prepared in Example 2 was mixed with hydrochloric acid and water to obtain the composition shown in Table 2. Table 2
  • Example 5 The aluminum complex prepared in Example 2 was mixed with hydrochloric acid, water and lactate to obtain the composition shown in Table 3.
  • the reference substance is commercially available basic aluminum chloride and aluminum chloride hexahydrate.
  • Example 1 The new aluminum complex described in Example 1 was further processed together with zirconium salt to form an antiperspirant mixture.
  • Table 8 shows that the new active ingredient complex with the complex ligands according to the invention shows reduced proportions of high polymer, while Al-oligomer and monomer species increase significantly.
  • Expand / elaborated zirconium salt to form an antiperspirant mixture Expand / elaborated zirconium salt to form an antiperspirant mixture.
  • Table 10 shows that the new active ingredient complex with the complex ligands according to the invention shows reduced proportions of high polymer, while Al-oligomer and monomer species increase significantly.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Geology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des complexes basiques d'halogénure d'aluminium que l'on obtient par réaction de métal d'aluminium avec de l'acide halohydrique et avec un acide organique. Selon l'invention, on dissout l'aluminium dans un mélange constitué d'acide halohydrique et d'acide organique ou bien on dissout d'abord le métal d'aluminium dans l'acide halohydrique puis on ajoute l'acide organique. Les complexes basiques d'halogénure d'aluminium ainsi modifiés par l'incorporation de liants d'acides organiques présentent une action améliorée en tant qu'agents antitranspirants.
EP05728684A 2004-03-26 2005-03-22 Complexes basiques d'halogenure d'aluminium Withdrawn EP1732848A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004015025A DE102004015025A1 (de) 2004-03-26 2004-03-26 Basische Aluminiumhalogenid-Komplexe
PCT/EP2005/003003 WO2005092795A1 (fr) 2004-03-26 2005-03-22 Complexes basiques d'halogenure d'aluminium

Publications (1)

Publication Number Publication Date
EP1732848A1 true EP1732848A1 (fr) 2006-12-20

Family

ID=34963174

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05728684A Withdrawn EP1732848A1 (fr) 2004-03-26 2005-03-22 Complexes basiques d'halogenure d'aluminium

Country Status (5)

Country Link
US (1) US20080069788A1 (fr)
EP (1) EP1732848A1 (fr)
JP (1) JP2007530482A (fr)
DE (1) DE102004015025A1 (fr)
WO (1) WO2005092795A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2006003116A1 (es) * 2005-11-16 2008-02-29 Colgate Palmolive Co Composicion antitranspirante que comprende al menos una sal elegida de aluminio, aluminio zirconio, una sal compleja de aluminio o una sal compleja de aluminio-zirconio, un hidroxiacido y un compuesto acido de amonio cuaternario; proceso para prepara
DE102013220782A1 (de) 2013-10-15 2014-04-17 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Phenylcarbonsäuren
DE102013220777A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit alpha-Hydroxysäuren
DE102013220771A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Polycarbonsäuren
DE102013220789A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit aromatischen Sulfonsäuren
DE102013220786A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Amidosulfonsäuren
DE102013220779A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Lactaten
DE102013220770A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Polyphosphorsäuren
DE102013220783A1 (de) 2013-10-15 2015-04-16 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Alkylsulfonsäuren
DE102013225620A1 (de) 2013-12-11 2015-06-11 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel ohne aluminiumhaltige Verbindungen II
DE102013225617A1 (de) 2013-12-11 2015-06-11 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel ohne aluminiumhaltige Verbindungen I
DE102013225616A1 (de) 2013-12-11 2015-06-11 Henkel Ag & Co. Kgaa Schweißhemmende kosmetische Mittel mit Lysozym und/oder Bovine serum albumin und/oder Yoghurt Protein
DE102014220918A1 (de) 2014-10-15 2016-04-21 Henkel Ag & Co. Kgaa Wirkstoffsystem für hochwirksame Antitranspirantien
DE102015210478A1 (de) 2015-06-09 2016-04-07 Henkel Ag & Co. Kgaa Schweißhemmende Kombination von verschiedenen Aluminiumsalzen
DE102015216588A1 (de) 2015-08-31 2017-03-02 Henkel Ag & Co. Kgaa Schweißhemmende O/W-Emulsionen mit Phosphat-haltigen Antitranspirantwirkstoffen
DE102015221058A1 (de) 2015-10-28 2017-05-04 Henkel Ag & Co. Kgaa "Schweißhemmende O/W-Emulsionen mit vernetzten Silikonpolymeren"

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054265A (fr) * 1962-11-07 1900-01-01
US3507896A (en) * 1968-10-23 1970-04-21 Armour Pharma Method of making alcohol-soluble complexes of aluminum
US4871525A (en) * 1986-10-24 1989-10-03 Westwood Chemical Corporation Antiperspirant composition and method of preparation
DE68912111T2 (de) * 1989-04-21 1994-06-16 Westwood Chemical Corp Verfahren zur Herstellung von basischen Aluminium-Haliden.
CA2090861C (fr) * 1990-09-07 2002-06-25 Jawahar C. Parekh Antisudorifiques basiques renfermant de l'aluminium et un melange d'aluminium et de zirconium et leur methode de fabrication

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005092795A1 *

Also Published As

Publication number Publication date
JP2007530482A (ja) 2007-11-01
DE102004015025A1 (de) 2005-10-13
US20080069788A1 (en) 2008-03-20
WO2005092795A1 (fr) 2005-10-06

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