EP1706210B1 - Vorrichtung zum haltern eines fluidischen bauteils - Google Patents

Vorrichtung zum haltern eines fluidischen bauteils Download PDF

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Publication number
EP1706210B1
EP1706210B1 EP04804353A EP04804353A EP1706210B1 EP 1706210 B1 EP1706210 B1 EP 1706210B1 EP 04804353 A EP04804353 A EP 04804353A EP 04804353 A EP04804353 A EP 04804353A EP 1706210 B1 EP1706210 B1 EP 1706210B1
Authority
EP
European Patent Office
Prior art keywords
fluidic component
holder
shaped part
elastomeric
elastomeric shaped
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP04804353A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1706210A1 (de
Inventor
Johannes Geser
Matthias Hausmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34744648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1706210(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to SI200430625T priority Critical patent/SI1706210T1/sl
Priority to PL04804353T priority patent/PL1706210T3/pl
Publication of EP1706210A1 publication Critical patent/EP1706210A1/de
Application granted granted Critical
Publication of EP1706210B1 publication Critical patent/EP1706210B1/de
Priority to CY20081100249T priority patent/CY1107900T1/el
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/14—Arrangements for preventing or controlling structural damage to spraying apparatus or its outlets, e.g. for breaking at desired places; Arrangements for handling or replacing damaged parts
    • B05B15/18—Arrangements for preventing or controlling structural damage to spraying apparatus or its outlets, e.g. for breaking at desired places; Arrangements for handling or replacing damaged parts for improving resistance to wear, e.g. inserts or coatings; for indicating wear; for handling or replacing worn parts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Definitions

  • the invention relates to a device for holding a fluidic component, in particular of nozzles, especially in the high pressure region.
  • a fluidic component in particular of nozzles, especially in the high pressure region.
  • holders for microstructured components in particular microstructured nozzles, which are produced by microstructuring.
  • Such nozzles are used, for example, in nebulizers for generating propellant-free medical aerosols used for inhalation.
  • the invention aims to further improve the mounting of a fluidic component made of a wear-resistant, hard and thus generally brittle material and to increase the reliability of the holder.
  • Microstructured nozzles with, for example, a nozzle opening of less than 10 microns are, for example, in WO 94/07607 and WO 99/16530 described.
  • the inhalable droplets thus produced have an average diameter of about 5 ⁇ m when the pressure of the liquid to be atomized is from 5 MPa (50 bar) to 40 MPa (400 bar).
  • the nozzles can be made of thin silicon plates and glass plates. The outer dimensions of the nozzles are in the millimeter range.
  • a typical nozzle, for example, consists of a cuboid with the edge lengths 1.1 mm, 1.5 mm and 2.0 mm, which is composed of two plates.
  • Nebulizers for producing propellant-free aerosols in which the device according to the invention for holding a fluidic component can be used are made of WO 91/14468 or WO 97/12687 known.
  • a component As a fluidic component, a component is referred to, which is exposed to a pressurized fluid, and the pressure also within the component, for example, in a nozzle bore, is present.
  • a component can be kept pressure-tight, for example, by pressing into a holder made of hard material, if the material of the component can absorb mechanical forces without breaking or deforming to an unacceptable extent.
  • seals made of deformable material for example made of copper or hard material are used, which are pressed with great force.
  • components made of brittle material require the known methods for pressure-tight mounting of the component a considerable Effort and great care. Over the life of such salaried fluidic component only little reliable information is possible.
  • a fluid jet cutting apparatus which produces a high velocity fluid jet used for cutting, drilling or abrading material.
  • the nozzle body is cylindrical and consists for example of sapphire or corundum.
  • the nozzle body is enclosed in a cylindrical ring, which consists of moderately yielding plastic material.
  • the Einfubbring is pressed into an annular recess of the nozzle carrier and seals the nozzle body against the nozzle carrier.
  • a nozzle holder for a water jet cutting apparatus in which the nozzle body is surrounded by a ring of elastomeric material, which in turn is disposed in a recess of the holder.
  • the recess has the shape of a straight cylinder.
  • the cross section of the ring is rectangular.
  • the mantle surface of the recess and the outer and inner circumferential surface of the ring are arranged concentrically to the axis of the nozzle body and run parallel to each other and to the axis of the nozzle body.
  • WO 97/12683 is a device for holding a fluidic component, which is exposed to a fluid pressure, known, which is suitable for components made of a wear-resistant, hard and thus generally brittle material, and which generates no unacceptably large punctual material stresses in the component.
  • the fluidic component is arranged in a holder, which contacts the fluidic component on its low-pressure side.
  • the fluidic component is surrounded by an elastomeric molded part whose outer contour is adapted to the inner contour of the holder and whose inner contour is adapted to the outer contour of the fluidic component.
  • the elastomeric molded part surrounds the fluidic component over its entire circumference. At least one free surface of the elastomeric molding is exposed to the pressurized fluid.
  • the holder may have on its inside a projection under which the elastomeric molding is pushed. It has been found difficult to produce in the elastomeric molding an internal stress which is sufficiently large even at low fluid pressure, and which is distributed approximately spatially evenly in the elastomeric molding.
  • This known device has proved to be pressure-tight at approximately constant load with medium and high fluid pressure. With changing load With a fluid pressure that varies between a high peak and a very small value, the known device for long-term use needs to be improved.
  • the elastomeric molding is beveled at its high pressure end to the recess.
  • the chamfering begins in the high-pressure-side lid surface of the elastomeric molded article on a closed line, which may be, for example, circular, elliptical or rectangular.
  • the chamfer may have a constant inclination angle, or the inclination angle may be different in azimuthal direction. In the latter case, it is preferably smaller in the direction of the larger side of a cuboidal fluidic component than in the direction of the smaller side of the cuboidal fluidic component.
  • the cutting curve of the taper with the recess in the elastomeric molding may be at a constant level, or the cutting curve may be curved.
  • the projection on the counterpart may preferably be annular and have a constant width.
  • the outer contour of the projection is preferably adapted to the inner contour of the holder.
  • the inner contour of the projection can be adapted to the outer contour of the fluidic component.
  • the protrusion on the counterpart can have a constant width and a constant height on its circumference, or the protrusion can be of different widths and / or heights. For example, in the two areas opposite the two larger sides of a parallelepipedic fluidic component, be higher than in the two areas, which are opposite to the two smaller sides of a cuboid fluidic component.
  • the internal stress in the elastomeric molded part ent-stands essentially by deformation of the elastomeric molding, not by its compression.
  • the deformation of the elastomeric molding and the distribution of stress in the elastomeric molding can be determined by the finite element method (FEM).
  • the elastomeric molded part is preferably produced as an injection-molded part.
  • the Cruelastomere is filled bubble-free in a shape that matches the contours of the holder and the fluidic component is adapted.
  • Such an elastomeric molded part behaves like an incompressible liquid. It is in register with the holder and the fluidic component.
  • the elastomeric molded part is exposed to the fluid pressure only on the pressure side, not on the sides against which it bears against the holder and the fluidic component.
  • the elastomeric molding allows the pressure compensation on the fluidic component.
  • the elastomeric molding has no free surface to the low pressure side.
  • the elastomeric molded part may be made of, for example, natural rubber or synthetic rubber such as silicone rubber, polyurethane, ethene-propene rubber (EPDM), fluororubber (FKM) or nitrile-butadiene rubber (NBR) or a corresponding rubber.
  • natural rubber or synthetic rubber such as silicone rubber, polyurethane, ethene-propene rubber (EPDM), fluororubber (FKM) or nitrile-butadiene rubber (NBR) or a corresponding rubber.
  • the fluidic component may be made of a wear-resistant, hard and thus generally brittle material (such as silicon, glass, ceramic, gemstone, eg sapphire, ruby, diamond) or of ductile material with wear-resistant hard surface (such as plastic, plastic metallized (chemical), Copper, hard chrome-plated copper, brass, aluminum, steel, hardened steel, wear-resistant surfaces produced by physical vapor deposition (PVD) or chemical vapor deposition (CVD, eg titanium nitride (TiN) or polycrystalline diamond on metal and / or
  • the fluidic component can be made in one piece or composed of several parts, the parts being made of different materials
  • the fluidic component can contain cavities, recesses or channel structures Microstructures can be arranged in the cavities Filter or as evaporation serve protection.
  • the channels may be nozzle channels for a spray nozzle.
  • An atomizer nozzle may include one or more nozzle channels whose axes may be parallel to each other or inclined relative to each other. For example, if there are two nozzle channels with their axes in one plane and intersecting outside the nozzle, the two fluid jets that hit each other meet at the intersection of the axes and the fluid is atomized.
  • the holder may be made of almost any material, preferably metal or plastic, and may be a rotary body or a body in any other shape.
  • the holder may be, for example, a cup-shaped rotary body which contains a - from its cover side outgoing - rotationally symmetrical recess whose axis coincides with the axis of the rotary body.
  • This recess can be cylindrical, or it may be frusto-conical, with the end of the truncated cone with the larger diameter in the lid side of the holder.
  • the lateral surface of the recess forms the inner contour of the holder. It can be produced as a formed part, as a casting or by machining (for example by machining, etching, eroding, Elysieren).
  • the counterpart can be made of metal or plastic.
  • the holder containing the elastomeric molding and the fluidic component is assembled with the counterpart.
  • the edge of the holder is based on the counterpart.
  • the fluidic component can be inserted into the elastomeric molded part, preferably before the elastomeric molded part is introduced into the recess in the holder.
  • the holder can be bolted to the counterpart, glued, welded, crimped, potted or fixed by means of press fit or snap on the counterpart.
  • the holder may preferably be secured by means of a union nut on the counterpart.
  • the counterpart in the region in which it is connected to the holder designed as a rotary body.
  • the high-pressure liquid is passed to the holder.
  • the liquid enters the channel structure in the fluidic component and leaves the fluidic component at its low-pressure side in the region of the holder bottom.
  • the fluid pressure acts within the dead volume on the elastomeric molding.
  • the inventive device for holding a fluidic component is, for example, in a miniaturized high-pressure atomizer (for example, according to WO91 / 12687 ), in a needleless injector (for example, according to WO01 / 64268 ) or in an applicator for ophthalmic drug formulations (for example according to WO03 / 002045 ) used.
  • a medical fluid administered with such a device may contain a drug dissolved in a solvent.
  • solvents for example, water, ethanol or mixtures thereof are suitable.
  • Berotec fenoterol hydrobromide, atrovent (ipratropium bromide), berodual (combination of fenoterol hydrobromide and ipratropium bromide), salbutamol (or albuterol), 1- (3,5-dihydroxyphenyl) -2 - [[1- (4-hydroxybenzyl) ethyl] amino] ethanol hydrobromide), Combivent, Oxivent (oxitropium bromide), Ba 679 (tiotropium bromide), BEA 2180 (di (2-thienyl) glycolic acid tropol ester), flunisolide , Budesonide and others used. Examples can be the WO97 / 01329 or the WO98 / 27959 be removed.
  • This device consists of a cylindrical steel holder with an outer diameter of 6.0 mm and a height of 2.6 mm. It contains a truncated cone-shaped recess with an inside diameter of 4.0 mm at the foot of the cone stump.
  • the bottom of the holder contains a hole of 0.8 mm diameter.
  • the bottom of the holder is 0.4 mm thick around the hole.
  • the outer contour of the elastomeric molding of silicone rubber is cylindrical.
  • the cylinder has a diameter of 4.2 mm before insertion into the holder and is 2.1 mm high in its outer surface. It contains a symmetrically arranged recess of 1.3 mm width and 2.8 mm length, which passes through the elastomeric molding in the axial direction.
  • the elastomeric molding is beveled at its high pressure end to the recess.
  • the taper begins in the top surface of the cylinder on a circle with a diameter of 3.2 mm.
  • the chamfer runs with different inclination in the direction of the rectangular recess to a constant depth of 0.7 mm at the intersection with the recess.
  • the fluidic component is designed as a spray nozzle.
  • the nozzle is a square composed of two silicon plates, 1.4 mm wide, 2.7 mm long and 2.1 mm high.
  • the nozzle includes in the contact surface of the plates a recess provided with a microstructured filter and a microstructured evaporation means.
  • the recess merges into two channels, each 8 ⁇ m wide, 6 ⁇ m deep and about 200 ⁇ m long.
  • the axes of the two channels lie in one plane and are inclined by about 90 degrees to each other.
  • the two nozzle openings have a distance of approximately 100 ⁇ m from each other on the outside of the atomizer nozzle.
  • the substantially cylindrical counterpart is provided on its side facing the holder with an annular projection.
  • the projection has an outer diameter of 3.15 mm, an inner diameter of 2.9 mm and a constant height of 0.6 mm.
  • the counterpart contains an axial bore of 0.4 mm diameter.
  • the device is attached to the counterpart by means of a union nut.
  • the counterpart is part of a container containing the liquid to be atomized.
  • the liquid is delivered by means of a miniaturized high pressure piston pump in subsets of about 15 microliters from the container to the atomizer.
  • the peak liquid pressure within the nebulizer nozzle is about 65 MPa (650 bar) and, after the end of nebulization, practically drops to the normal barometric pressure (about 0.1 MPa).

Landscapes

  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Nozzles (AREA)
  • Combined Devices Of Dampers And Springs (AREA)
  • Manipulator (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Heating, Cooling, Or Curing Plastics Or The Like In General (AREA)
  • Measuring Fluid Pressure (AREA)
  • Clamps And Clips (AREA)
EP04804353A 2004-01-08 2004-12-28 Vorrichtung zum haltern eines fluidischen bauteils Active EP1706210B1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI200430625T SI1706210T1 (sl) 2004-01-08 2004-12-28 Naprava za drĹľanje fluidne komponente
PL04804353T PL1706210T3 (pl) 2004-01-08 2004-12-28 Urządzenie do mocowania przepływowego elementu konstrukcyjnego
CY20081100249T CY1107900T1 (el) 2004-01-08 2008-03-04 Μια συσκευη για τη συγκρατηση ενος δομικου τμηματος το οποιο δεχεται την πιεση ενος ρευστου

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004001451A DE102004001451A1 (de) 2004-01-08 2004-01-08 Vorrichtung zum Haltern eines fluidischen Bauteiles
PCT/EP2004/014764 WO2005065836A1 (de) 2004-01-08 2004-12-28 Vorrichtung zum haltern eines fluidischen bauteils

Publications (2)

Publication Number Publication Date
EP1706210A1 EP1706210A1 (de) 2006-10-04
EP1706210B1 true EP1706210B1 (de) 2007-12-12

Family

ID=34744648

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04804353A Active EP1706210B1 (de) 2004-01-08 2004-12-28 Vorrichtung zum haltern eines fluidischen bauteils

Country Status (29)

Country Link
US (2) US7837235B2 (es)
EP (1) EP1706210B1 (es)
JP (1) JP4382097B2 (es)
KR (1) KR20060134060A (es)
CN (1) CN1921949B (es)
AT (1) ATE380595T1 (es)
AU (1) AU2004311644A1 (es)
BR (1) BRPI0418364B1 (es)
CA (1) CA2552535C (es)
CO (1) CO5700802A2 (es)
CY (1) CY1107900T1 (es)
DE (2) DE102004001451A1 (es)
DK (1) DK1706210T3 (es)
EA (1) EA008630B1 (es)
EC (1) ECSP066691A (es)
EG (1) EG25014A (es)
ES (1) ES2298851T3 (es)
HR (1) HRP20080013T3 (es)
IL (1) IL176741A0 (es)
ME (1) ME00797B (es)
MX (1) MXPA06007670A (es)
NO (1) NO20062759L (es)
PL (1) PL1706210T3 (es)
PT (1) PT1706210E (es)
RS (1) RS50551B (es)
SI (1) SI1706210T1 (es)
UA (1) UA85865C2 (es)
WO (1) WO2005065836A1 (es)
ZA (1) ZA200604658B (es)

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JP2007517646A (ja) 2007-07-05
CA2552535C (en) 2014-05-27
EP1706210A1 (de) 2006-10-04
US20050194472A1 (en) 2005-09-08
DE102004001451A1 (de) 2005-08-11
CA2552535A1 (en) 2005-07-21
ME00797B (me) 2012-03-20
CO5700802A2 (es) 2006-11-30
EG25014A (en) 2011-05-25
US9027967B2 (en) 2015-05-12
CY1107900T1 (el) 2013-09-04
JP4382097B2 (ja) 2009-12-09
NO20062759L (no) 2006-08-07
AU2004311644A1 (en) 2005-07-21
BRPI0418364B1 (pt) 2017-06-27
EA200601207A1 (ru) 2006-12-29
WO2005065836A1 (de) 2005-07-21
UA85865C2 (uk) 2009-03-10
HRP20080013T3 (en) 2008-02-29
DE502004005733D1 (de) 2008-01-24
ES2298851T3 (es) 2008-05-16
PT1706210E (pt) 2008-01-04
PL1706210T3 (pl) 2008-05-30
ATE380595T1 (de) 2007-12-15
CN1921949A (zh) 2007-02-28
IL176741A0 (en) 2006-10-31
US20100154792A1 (en) 2010-06-24
ZA200604658B (en) 2007-10-31
ECSP066691A (es) 2006-10-31
KR20060134060A (ko) 2006-12-27
US7837235B2 (en) 2010-11-23
SI1706210T1 (sl) 2008-06-30
MXPA06007670A (es) 2006-09-01
EA008630B1 (ru) 2007-06-29
CN1921949B (zh) 2012-05-30
DK1706210T3 (da) 2008-02-18
RS50551B (sr) 2010-05-07
BRPI0418364A (pt) 2007-05-15

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