EP1663100B1 - Recipient pour liquides de perfusion - Google Patents

Recipient pour liquides de perfusion Download PDF

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Publication number
EP1663100B1
EP1663100B1 EP04765054A EP04765054A EP1663100B1 EP 1663100 B1 EP1663100 B1 EP 1663100B1 EP 04765054 A EP04765054 A EP 04765054A EP 04765054 A EP04765054 A EP 04765054A EP 1663100 B1 EP1663100 B1 EP 1663100B1
Authority
EP
European Patent Office
Prior art keywords
container
volume
fold lines
standing
walls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP04765054A
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German (de)
English (en)
Other versions
EP1663100A1 (fr
Inventor
Joachim Beine
Torsten DÖNHOFF
Volker Harms
Hans-Otto Maier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
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B Braun Melsungen AG
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Filing date
Publication date
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Priority to PL04765054T priority Critical patent/PL1663100T3/pl
Publication of EP1663100A1 publication Critical patent/EP1663100A1/fr
Application granted granted Critical
Publication of EP1663100B1 publication Critical patent/EP1663100B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C37/00—Component parts, details, accessories or auxiliary operations, not covered by group B29C33/00 or B29C35/00
    • B29C37/0053—Moulding articles characterised by the shape of the surface, e.g. ribs, high polish
    • B29C37/0057—Moulding single grooves or ribs, e.g. tear lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
    • B29C49/04—Extrusion blow-moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/22—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor using multilayered preforms or parisons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/0292—Foldable bottles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2791/00—Shaping characteristics in general
    • B29C2791/001—Shaping in several steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/08—Biaxial stretching during blow-moulding
    • B29C49/10—Biaxial stretching during blow-moulding using mechanical means for prestretching
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/4273—Auxiliary operations after the blow-moulding operation not otherwise provided for
    • B29C49/428—Joining
    • B29C49/42802—Joining a closure or a sealing foil to the article or pincing the opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/4273—Auxiliary operations after the blow-moulding operation not otherwise provided for
    • B29C49/42815—Emptying the article, e.g. emptying hydraulic blowing fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C53/00—Shaping by bending, folding, twisting, straightening or flattening; Apparatus therefor
    • B29C53/02—Bending or folding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04—Polymers of ethylene
    • B29K2023/08—Copolymers of ethylene
    • B29K2023/086—EVOH, i.e. ethylene vinyl alcohol copolymer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/10—Polymers of propylene
    • B29K2023/12—PP, i.e. polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2077/00—Use of PA, i.e. polyamides, e.g. polyesteramides or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B38/00—Ancillary operations in connection with laminating processes
    • B32B38/0012—Mechanical treatment, e.g. roughening, deforming, stretching
    • B32B2038/0028—Stretching, elongating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B38/00—Ancillary operations in connection with laminating processes
    • B32B2038/0052—Other operations not otherwise provided for
    • B32B2038/0088—Expanding, swelling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/40—Properties of the layers or laminate having particular optical properties
    • B32B2307/412—Transparent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2323/00—Polyalkenes
    • B32B2323/10—Polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles

Definitions

  • the invention relates to a molded stable container for infusion liquids, with walls that form a floor and a shoulder area merging into a neck area.
  • Such rigid containers are not suitable for pressure infusions in which the infusion fluid is forced out of the container by application of external pressure.
  • Pressure infusions are administered to patients in the hypovolemic state after loss of large quantities of blood, for example after a traffic accident, in order to supply the patient with a large amount of fluid in a short time.
  • Druckinfusions en own foil bags, in which the infusion liquid is contained.
  • the foil bags contain no air and their volume adapts to the respective volume of liquid.
  • the material used is multilayer composite films, wherein at least one of the layers has special barrier properties.
  • BFS blow-fill-seal
  • JP 2002 282 335 A an infusion container is described which corresponds to the preamble of patent claim 1.
  • the infusion container consists of a shaped body, which can be folded in the empty state before filling and after removing the liquid. However, during filling of the infusion solution and during transport after filling, the container may stand upright.
  • the container has on two opposite side surfaces in reverse - y-shaped outer fold lines and a participatfaltline connecting transverse réellefaltline. When the container base folds up, the outer fold lines soften outwards, while the inner fold line buckles. There is no folding in the neck area of the container.
  • the container is deformed by manual action, the deformation behavior being influenced by the location of the pressure application.
  • DE 37 27 972 A1 is a trained as a bag liquid container for receiving drinks, such as orange juice and soft drinks, described.
  • the bag is a gusseted bag with multiple vertical welds.
  • the bottom consists of folded tabs.
  • the bag is self-standing only in the filled state. It is not intended for hanging.
  • DE 699 03 510 T2 describes a general cube-shaped large bag for use in the biopharmaceutical industry, which is made as a bellows bag of welded films. It is not a molded container. The container also has no neck area and no shoulder area.
  • a gusseted medical bag is in DE 699 00 761 T2 described.
  • the gusseted bag has a cuboid shape when filled, with the bottom consisting of triangular tabs connected by sealing seams.
  • Foil bags with numerous sealing seams require a relatively complicated production.
  • a collapsible container which consists of a one-piece molded part and has longitudinal gussets.
  • the container is designed to be manually compressed to take up little space during waste disposal.
  • a molded stable container for infusion liquids which substantially corresponds to the preamble of claim 1 is described in US 3,926,341 A .
  • This container is manufactured by extrusion blow molding. It consists of a semi-rigid plastic bottle, which is provided with bending lines. Longitudinal bending lines each produce an inner fold between two outer folds, so that the flat side walls approach each other when emptying the container, while the narrow walls are folded accordion-like.
  • the bottle has a floor, which is drawn to the inside of the bottle when emptying.
  • the bottle has a shoulder area that merges into a neck area and is free of bending lines. The shoulder area is therefore stiff.
  • the invention has for its object to provide a molded container that is simple and inexpensive to produce and pressure infusions allows without requiring a larger volume of air.
  • the shaped stable container according to the invention comprises the features of claim 1.
  • a "shaped container” is understood to mean a container whose shape is determined during manufacture and which therefore has a predetermined shape and also adheres to it when placed on a base, in contrast to a foil bag. This stability can be positively influenced by molded nubs.
  • the container according to the invention is deformable by the external air pressure (ambient pressure). Further, the container is deformable by applying force to the container wall to perform a pressure infusion.
  • the required air volume for emptying the container is reduced to a considerable extent. It is therefore necessary to provide in the container only a minimal volume of air corresponding to this residual volume.
  • the container is almost free of air in the filling state. This means that the air volume makes up a maximum of 15% of the container volume.
  • the volume of air is between 20 and 40% of the container volume depending on the filling volume / container size. Since the container according to the invention is still partially pressed in the filled state and thus still has a volume reserve for the addition of a Zuspritzmenge, a larger volume of air is not required.
  • the container according to the invention can be produced relatively easily, for example in the BFS method, either in a single-layer or multi-layered manner.
  • the advantages of a film bag, namely minimal residual or air volume, and a container produced in the BFS process, namely cost-effective production, are combined in the container according to the invention.
  • the bending lines are formed by a targeted manipulation in the wall thickness profile in the walls.
  • a bending line can be blow-molded.
  • the blow mold must have corresponding webs, which cause an image of said fold lines.
  • the foldability of the shoulder region is preferably achieved by arranging a plurality of bending lines in a group such that they result in an accordion-like folding.
  • the dimensional stability of the shoulder region is usually large, because the shoulder region, depending on the container geometry, is pyramidal or frustoconical. The dimensional stability is further increased by the fact that the shoulder area is limited by body edges with increased bending stiffness. The relatively large volume that encloses the shoulder area is considerably reduced by the accordion-like folding and the corresponding flattening.
  • the floor of a bending line is formed as a transverse fold, which moves outward when flattening.
  • the floor is designed so that it shifts to the outside (and not inward) when laying flat, because this can reduce the container volume the most.
  • the invention further relates to a method for filling a container with infusion liquid after its formation. If in an infusion container, a liquid, eg. As a drug is injected, the closed container must receive an additional volume of fluid. If it is a rigid container, thereby increasing the internal pressure of the container. If it is a flexible bag, the bag wall is additionally stretched.
  • a liquid eg. As a drug is injected
  • the closed container must receive an additional volume of fluid. If it is a rigid container, thereby increasing the internal pressure of the container. If it is a flexible bag, the bag wall is additionally stretched.
  • the new method is based on the object of specifying a method for filling a container, with which it can be ensured that in the case of the injection of a liquid no significant mechanical stress on the container takes place.
  • the container is pressed after shaping to reduce its volume and filled in this state, wherein the impressions a volume reserve for recording a later supplied Zuspritzmenge is provided.
  • the depression of the container means that it does not provide its entire volume during the filling process. Rather, a part of a wall is forcibly deformed so that the wall does not occupy the substantially tension-free final state, but is curved inwards.
  • the container is therefore filled only incompletely, in order subsequently to be able to absorb an amount of injection, whereby it assumes its intended final volume.
  • the illustrated container 10 has an elongated hollow body 11 bounded by four walls 12, 13.
  • the body 12 has a rectangular shape. It merges at its one end into a truncated pyramidal shoulder region 14, to which an elongated rectangular neck region 15 extending parallel to the walls 12 adjoins.
  • a port system 16 with two ports 16a, 16b, each of which receives a pierceable membrane containing removal opening.
  • Each port has a tear-off part 17a, 17b which can be torn off to expose the membrane so that the piercing spike of a transmission device can be pierced.
  • One of the ports serves as a withdrawal port and the other as an injection port. Lateral tabs are provided on the ports, allowing the connection of monovial containers.
  • the floor 20 of the body 12 includes a bottom wall 21. From this is a suspension tab 22 from to hang the container with downwardly directed removal opening can.
  • the bottom of the stand may also contain stand nubs 24. The stand nubs 24 create a space for accommodating the laterally bent suspension lug and cause a safe and tilt-free state of the container.
  • the container 10 is, with the exception of the port system 16, made in one piece and filled with infusion fluid. Usually it consists of materials of a polyolefinic nature, e.g. LDPE, LLDPE, PP.
  • the container is provided with bending lines BL, which are located primarily in the floor 20 and extend in the shoulder region 14.
  • a bending line 25a runs across the floor 20.
  • the bending line 25a has a central portion from which the tab 22 protrudes. From the two ends of the central portion go further bending lines 30, which extend radially into the corners of the bottom wall 21.
  • the bend lines 26 generally extend longitudinally of the container and are arranged to give an accordion-like fold, breaking the transitional edge 27 between the body 12 and the shoulder region 14.
  • One or more further bending lines 28 extend along a wall 13 in the longitudinal direction of the container. At the longitudinal edges of the container more bending lines 32 are provided. While the bend line 28 forms an inner fold, the bend lines 32 form outer folds which connect the corners of the body 11. One or more corresponding bending lines run on the in Fig. 1 invisible wall opposite. When the container is laid flat, the bending lines 28 move inwards and the bending line 25 located in the bottom moves outwards.
  • FIG. 2 shows a cross section of the wall 13 with the formed therein bending line BL.
  • the wall thickness is reduced, so that there the bending stiffness is significantly reduced.
  • the bending line BL can be produced by providing a rib facing the mold cavity in the wall of the blow mold. This creates the bending line on the outside of the container, while the inside of the container is smooth. In principle, however, the fold can be produced on the inside of the container by tool-side depressions.
  • the container described is completely or almost completely filled with liquid.
  • the Liquid level 29 with the container standing upright in the upper part of the shoulder region 14. There is only a relatively small amount of air, which is sufficient to fill the container volume is still present in a deformed container.
  • FIG. 3 shows the container in the collapsed state after removal of the contents. It can be seen that the side walls 13 like the walls of a gusseted bag are folded longitudinally and laid with their halves against each other, wherein the bending line 28 form an inner fold and the bending lines 32 outer folds. This side fold continues into the floor 20 and the shoulder area 14. Also in the shoulder region 14 are bending lines, which form a continuation of the longitudinal bending lines 28 and 32 of the body 11.
  • the total wall thickness of the container wall 41 is from 0.1 mm to 0.7 mm. About 40% to 70% of the total wall thickness is attributable to the inner layer 42 and 10% to the barrier layer 44 and the adhesion promoter layers 43 and 45. The remainder of the wall thickness is attributable to the outer layer 46.
  • the preform 50 consists of a straight tube having a circular cross section and containing the individual layers 42 to 46 in a coaxial tubular arrangement.
  • the preform is expanded in a blow mold and brought to its final shape.
  • the wall thickness is reduced to 0.1 mm to 0.7 mm.
  • the materials used are chosen so that the container in combination with the low wall thickness has a high transparency, which differs significantly above the transparency of conventional (co) extrusion blow molded container for infusion solutions with polyolefinic structure (PP / PE / COC).
  • PP / PE / COC polyolefinic structure
  • a significant increase in transparency can be achieved by axial stretching of the preform prior to the blowing process.
  • FIG. 6 shows another preform 50, which has a profiled cross section deviating from the round cross section.
  • the cross section of the preform 51 which has the same layers as the preform 50, is here that of an elongated rectangle with strongly rounded corners.
  • the (not shown) extrusion die in the tool head of the extrusion die has a corresponding profile shape.
  • the material distribution in the preform 51 is selected such that a circumferentially uniform wall thickness of the container results in the subsequent expansion blow molding process.
  • the formation of in FIG. 4 The container shown is preferably such that this container has bending lines in the walls of the stand and / or the shoulder region.
  • this container has bending lines in the walls of the stand and / or the shoulder region.
  • the container deforms in the area of the floor and in the shoulder area during liquid removal from the container without such bending lines are present.
  • preformed bend lines or weakened areas facilitate the defined collapse and a proper folding of the container.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (9)

  1. Récipient moulé pour liquides de perfusion, apte à rester debout, comprenant des parois (12, 13) formant un fond de support (20) plat permettant de dresser ledit récipient, et formant une partie d'épaulement (14) passant dans une partie de cou (15), les parois du fond de support (20) et/ou de la partie d'épaulement (14) étant formées avec des lignes de pli (BL) qui sont disposées et formées de sorte qu'elles causent la mise à plat de la partie comprenant les lignes de pli quand l'on enlève du liquide du récipient (10) sans aération,
    caractérisé en ce que
    une ligne de pli (25a), s'étendant transversalement sur ledit fond de support (20), est formée dans ledit fond de support comme pli transversale qui se déplace vers l'extérieur pendant la mise à plat.
  2. Récipient selon la revendication 1, caractérisé en ce que lesdites lignes de pli (BL) sont formées par des lignes d'affaiblissement dans les parois (13).
  3. Récipient selon les revendications 1 ou 2, caractérisé en ce que plusieurs lignes de pli (BL) sont disposées dans un groupe de lignes de pli (26) de sorte qu'elles forment un pliage du type accordéon.
  4. Récipient selon les revendications 1-3, caractérisé en ce que plusieurs lignes de pli (28, 32) s'étendent, comme plis longitudinales, du fond de support (20) jusque dans ladite partie d'épaulement (14).
  5. Récipient selon les revendications 1 - 4, caractérisé en ce que le récipient rempli a un volume d'air qui est au maximum 15% du volume du récipient.
  6. Récipient selon les revendications 1 - 5, caractérisé en ce que le volume de remplissage du récipient est entre 1 ml et 5000 ml.
  7. Récipient selon les revendications 1 - 6, caractérisé en ce que la partie de cou (15) est munie d'un système de ports (16) comprenant une membrane perçable.
  8. Récipient selon les revendications 1 - 7, caractérisé en ce que le fond de support (20) comprend une patte de suspension (22) en saillie.
  9. Procédé de remplissage d'un récipient selon les revendications 1-8 avec liquide de perfusion, caractérisé en ce qu'après moulage, ledit récipient est pressé pour réduire son volume et qu'il est rempli et fermé dans cet état, le fait qu'il est pressé fournissant une réserve de volume pour recevoir une quantité injectée plus tard.
EP04765054A 2003-09-16 2004-09-10 Recipient pour liquides de perfusion Expired - Lifetime EP1663100B1 (fr)

Priority Applications (1)

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PL04765054T PL1663100T3 (pl) 2003-09-16 2004-09-10 Pojemnik na płyny infuzyjne

Applications Claiming Priority (2)

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DE10342742A DE10342742A1 (de) 2003-09-16 2003-09-16 Behälter für Infusionsflüssigkeiten
PCT/EP2004/010125 WO2005032450A1 (fr) 2003-09-16 2004-09-10 Recipient pour liquides de perfusion

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EP1663100A1 EP1663100A1 (fr) 2006-06-07
EP1663100B1 true EP1663100B1 (fr) 2012-01-18

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US (1) US8172110B2 (fr)
EP (1) EP1663100B1 (fr)
AT (1) ATE541549T1 (fr)
DE (1) DE10342742A1 (fr)
ES (1) ES2380933T3 (fr)
PL (1) PL1663100T3 (fr)
WO (1) WO2005032450A1 (fr)

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Also Published As

Publication number Publication date
ATE541549T1 (de) 2012-02-15
ES2380933T3 (es) 2012-05-21
PL1663100T3 (pl) 2012-06-29
EP1663100A1 (fr) 2006-06-07
US8172110B2 (en) 2012-05-08
WO2005032450A1 (fr) 2005-04-14
US20070272705A1 (en) 2007-11-29
DE10342742A1 (de) 2005-05-12

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