EP1627912A1 - Herstellung endodermaler stammzellen - Google Patents

Herstellung endodermaler stammzellen Download PDF

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Publication number
EP1627912A1
EP1627912A1 EP04734133A EP04734133A EP1627912A1 EP 1627912 A1 EP1627912 A1 EP 1627912A1 EP 04734133 A EP04734133 A EP 04734133A EP 04734133 A EP04734133 A EP 04734133A EP 1627912 A1 EP1627912 A1 EP 1627912A1
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EP
European Patent Office
Prior art keywords
cells
cell
stem cells
endodermal
stem cell
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Withdrawn
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EP04734133A
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English (en)
French (fr)
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EP1627912A4 (de
Inventor
Shinichi Nishikawa
Takumi Era
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RIKEN Institute of Physical and Chemical Research
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RIKEN Institute of Physical and Chemical Research
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Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research
Publication of EP1627912A1 publication Critical patent/EP1627912A1/de
Publication of EP1627912A4 publication Critical patent/EP1627912A4/de
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP04734133A 2003-05-20 2004-05-20 Herstellung endodermaler stammzellen Withdrawn EP1627912A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003142303 2003-05-20
PCT/JP2004/007227 WO2004104184A1 (ja) 2003-05-20 2004-05-20 内胚葉系幹細胞の調製

Publications (2)

Publication Number Publication Date
EP1627912A1 true EP1627912A1 (de) 2006-02-22
EP1627912A4 EP1627912A4 (de) 2007-12-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP04734133A Withdrawn EP1627912A4 (de) 2003-05-20 2004-05-20 Herstellung endodermaler stammzellen

Country Status (8)

Country Link
US (1) US20060281136A1 (de)
EP (1) EP1627912A4 (de)
JP (1) JPWO2004104184A1 (de)
KR (1) KR20060010820A (de)
CN (1) CN1791668A (de)
AU (1) AU2004241380A1 (de)
CA (1) CA2526397A1 (de)
WO (1) WO2004104184A1 (de)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075807A3 (en) * 2005-12-20 2008-01-31 Es Cell Int Pte Ltd Methods for the directed differentiation of embryonic stem cell
WO2009041984A1 (en) * 2007-09-24 2009-04-02 Cythera, Inc. Methods for increasing definitive endoderm production
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US7993920B2 (en) 2006-03-02 2011-08-09 Viacyte, Inc. Methods of producing pancreatic hormones
US8129182B2 (en) 2006-03-02 2012-03-06 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US8216836B2 (en) 2003-12-23 2012-07-10 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US8623645B2 (en) 2003-12-23 2014-01-07 Viacyte, Inc. Definitive endoderm
US8633024B2 (en) 2004-04-27 2014-01-21 Viacyte, Inc. PDX1 expressing endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US8658151B2 (en) 2003-12-23 2014-02-25 Viacyte, Inc. Expansion of definitive endoderm cells
US9499795B2 (en) 2005-10-27 2016-11-22 Viacyte, Inc. PDX1-expressing dorsal and ventral foregut endoderm
US9764062B2 (en) 2008-11-14 2017-09-19 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070053885A1 (en) * 2003-05-28 2007-03-08 Shinichi Nishikawa Mesenchymal stem cell
WO2006020919A2 (en) * 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
AU2011295722B2 (en) 2010-09-03 2016-04-21 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
JP6148429B2 (ja) * 2011-01-31 2017-06-14 協和発酵バイオ株式会社 ヒト多能性幹細胞の培養方法
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
CN107345897A (zh) * 2016-05-04 2017-11-14 上海米洋杨生物科技有限公司 一种视网膜感光细胞特异性表面蛋白的筛选方法
EP3483262B1 (de) * 2016-06-03 2021-11-17 Institue of Transfusion Medicine, Academy of Military Medical Sciences, People's Liberation Army of China Kombination von niedermolekularen verbindungen zur umprogrammierung von epithelzellen aus dem verdauungstrakt in endodermale stamm-/vorläuferzellen, verfahren zur umprogrammierung und anwendung
CN113041262B (zh) * 2019-12-26 2023-08-04 中国科学院分子细胞科学卓越创新中心 内胚层干细胞在预防和/或治疗肝脏免疫失调疾病中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001552A1 (de) * 1997-07-02 1999-01-14 Hescheler Juergen Fluoreszierende proteine als zelltypspezifische reporter
WO2002051987A1 (de) * 2000-12-27 2002-07-04 Axiogenesis Ag System zur zell-und entwicklungsspezifischen selektion differenzierender embryonaler stammzellen; adulter stammzellen und embryonaler keinbahnzellen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639618A (en) * 1994-05-13 1997-06-17 Plurion, Inc. Method of isolating a lineage specific stem cell in vitro
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
AUPR349501A0 (en) * 2001-03-02 2001-03-29 Bresagen Limited Cellular production control
KR101089591B1 (ko) * 2001-12-07 2011-12-05 제론 코포레이션 인간 배아 줄기세포 유래의 섬세포

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001552A1 (de) * 1997-07-02 1999-01-14 Hescheler Juergen Fluoreszierende proteine als zelltypspezifische reporter
WO2002051987A1 (de) * 2000-12-27 2002-07-04 Axiogenesis Ag System zur zell-und entwicklungsspezifischen selektion differenzierender embryonaler stammzellen; adulter stammzellen und embryonaler keinbahnzellen

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANDRESSEN CHRISTIAN ET AL: "Nestin-specific green fluorescent protein expression in embryonic stem cell-derived neural precursor cells used for transplantation" STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 19, no. 5, 2001, pages 419-424, XP002197255 ISSN: 1066-5099 *
D'AMOUR K A ET AL: "Efficient differentiation of human embryonic stem cells to definitive endoderm" NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 12, 28 October 2005 (2005-10-28), pages 1534-1541, XP002385437 ISSN: 1087-0156 *
KUBO A ET AL: "Development of definitive endoderm from embryonic stem cells in culture" DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE,, GB, vol. 131, no. 7, April 2004 (2004-04), pages 1651-1662, XP002985523 ISSN: 0950-1991 *
MARVIN M ET AL: "MULTIPOTENTIAL STEM CELLS IN THE VERTEBRATE CNS" SEMINARS IN CELL BIOLOGY, SAUNDERS SCIENTIFIC PUBLICATIONS, PHILADELPHIA,, US, vol. 3, 1992, pages 401-411, XP002064929 ISSN: 1043-4675 *
MUELLER M ET AL: "Selection of ventricular-like cardiomyocytes from ES cells in vitro" FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 14, no. 15, December 2000 (2000-12), pages 2540-2548, XP002197256 ISSN: 0892-6638 *
See also references of WO2004104184A1 *
TADA S ET AL: "CHARACTERIZATION OF MESENDODERM: A DIVERGING POINT OF THE DEFINITIVE ENDODERM AND MESODERM IN EMBRYONIC STEM CELL DIFFERENTIATION CULTURE" DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE,, GB, vol. 132, no. 19, October 2005 (2005-10), pages 4363-4374, XP008054294 ISSN: 0950-1991 *
YASUNAGA M ET AL: "Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells" NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 12, 27 November 2005 (2005-11-27), pages 1542-1550, XP002385438 ISSN: 1087-0156 *
ZUK P A ET AL: "Human adipose tissue is a source of multipotent stem cells" MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 13, no. 12, 20 December 2002 (2002-12-20), pages 4279-4295, XP002249630 ISSN: 1059-1524 *

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8623645B2 (en) 2003-12-23 2014-01-07 Viacyte, Inc. Definitive endoderm
US9732318B2 (en) 2003-12-23 2017-08-15 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US11667889B2 (en) 2003-12-23 2023-06-06 Viacyte, Inc. Methods of making human primitive ectoderm cells
US9605243B2 (en) 2003-12-23 2017-03-28 Viacyte, Inc. Markers of definitive endoderm
US8658151B2 (en) 2003-12-23 2014-02-25 Viacyte, Inc. Expansion of definitive endoderm cells
US10550367B2 (en) 2003-12-23 2020-02-04 Viacyte, Inc. Methods of making human primitive ectoderm cells
US10179902B2 (en) 2003-12-23 2019-01-15 Viacyte, Inc. Methods of making human primitive ectoderm cells
US8216836B2 (en) 2003-12-23 2012-07-10 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US10421942B2 (en) 2003-12-23 2019-09-24 Viacyte, Inc. Definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US8633024B2 (en) 2004-04-27 2014-01-21 Viacyte, Inc. PDX1 expressing endoderm
US10465162B2 (en) 2004-04-27 2019-11-05 Viacyte, Inc. Anterior endoderm cells and methods of production
US9222069B2 (en) 2004-04-27 2015-12-29 Viacyte, Inc. Methods for making anterior foregut endoderm
US11746323B2 (en) 2004-04-27 2023-09-05 Viacyte, Inc. PDX1 positive foregut endoderm cells and methods of production
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US11427805B2 (en) 2005-10-27 2022-08-30 Viacyte, Inc. Methods of producing human foregut endoderm cells expressing PDX1 from human definitive endoderm
US9499795B2 (en) 2005-10-27 2016-11-22 Viacyte, Inc. PDX1-expressing dorsal and ventral foregut endoderm
WO2007075807A3 (en) * 2005-12-20 2008-01-31 Es Cell Int Pte Ltd Methods for the directed differentiation of embryonic stem cell
US9585917B2 (en) 2006-03-02 2017-03-07 Viacyte, Inc. Methods of producing pancreatic hormones
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
US9980986B2 (en) 2006-03-02 2018-05-29 Viacyte, Inc. Methods of producing pancreatic hormones
US11896622B2 (en) 2006-03-02 2024-02-13 Viacyte, Inc. Methods of producing pancreatic hormones
US7993920B2 (en) 2006-03-02 2011-08-09 Viacyte, Inc. Methods of producing pancreatic hormones
US10370645B2 (en) 2006-03-02 2019-08-06 Emory University Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US8603811B2 (en) 2006-03-02 2013-12-10 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US8129182B2 (en) 2006-03-02 2012-03-06 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US10517901B2 (en) 2006-03-02 2019-12-31 Viacyte, Inc. Methods of lowering blood glucose levels in a mammal
US7993916B2 (en) 2007-09-24 2011-08-09 Viacyte, Inc. Methods for increasing definitive endoderm production
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
WO2009041984A1 (en) * 2007-09-24 2009-04-02 Cythera, Inc. Methods for increasing definitive endoderm production
US9913930B2 (en) 2008-11-14 2018-03-13 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US10272179B2 (en) 2008-11-14 2019-04-30 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US11660377B2 (en) 2008-11-14 2023-05-30 Viacyte, Inc. Cryopreserved in vitro cell culture of human pancreatic progenitor cells
US9764062B2 (en) 2008-11-14 2017-09-19 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells

Also Published As

Publication number Publication date
WO2004104184A1 (ja) 2004-12-02
KR20060010820A (ko) 2006-02-02
US20060281136A1 (en) 2006-12-14
EP1627912A4 (de) 2007-12-12
CA2526397A1 (en) 2004-12-02
AU2004241380A1 (en) 2004-12-02
CN1791668A (zh) 2006-06-21
JPWO2004104184A1 (ja) 2006-07-20

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