EP1615944A4 - Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren - Google Patents

Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren

Info

Publication number
EP1615944A4
EP1615944A4 EP04749530A EP04749530A EP1615944A4 EP 1615944 A4 EP1615944 A4 EP 1615944A4 EP 04749530 A EP04749530 A EP 04749530A EP 04749530 A EP04749530 A EP 04749530A EP 1615944 A4 EP1615944 A4 EP 1615944A4
Authority
EP
European Patent Office
Prior art keywords
antiandrogens
marginal
methods
agonist activity
agonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP04749530A
Other languages
English (en)
French (fr)
Other versions
EP1615944A2 (de
Inventor
Henry A Lardy
Ashok K Marwah
Padma Marwah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbor Biosciences Inc
Original Assignee
Harbor Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Biosciences Inc filed Critical Harbor Biosciences Inc
Publication of EP1615944A2 publication Critical patent/EP1615944A2/de
Publication of EP1615944A4 publication Critical patent/EP1615944A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP04749530A 2003-04-01 2004-03-30 Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren Ceased EP1615944A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45945003P 2003-04-01 2003-04-01
PCT/US2004/009739 WO2004089304A2 (en) 2003-04-01 2004-03-30 Antiandrogens with marginal agonist activity and methods of use

Publications (2)

Publication Number Publication Date
EP1615944A2 EP1615944A2 (de) 2006-01-18
EP1615944A4 true EP1615944A4 (de) 2010-08-11

Family

ID=33159654

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04749530A Ceased EP1615944A4 (de) 2003-04-01 2004-03-30 Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren

Country Status (4)

Country Link
US (7) US20040242618A1 (de)
EP (1) EP1615944A4 (de)
CA (1) CA2522784C (de)
WO (1) WO2004089304A2 (de)

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US20060079492A1 (en) * 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
PT1955700E (pt) * 1999-09-30 2011-05-04 Harbor Biosciences Inc Tratamento terap?utico de doen?as associadas ao receptor de androg?nios
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
WO2004019953A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
EP1615944A4 (de) 2003-04-01 2010-08-11 Harbor Biosciences Inc Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren
EP2471536A1 (de) * 2004-09-29 2012-07-04 Harbor BioSciences, Inc. Steroidanaloga sowie charakterisierungs- und behandlungsverfahren
US7910755B2 (en) * 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) * 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
CN100422204C (zh) * 2006-03-02 2008-10-01 云南大学 一种7-酮基去氢表雄酮及其醋酸酯的合成方法
US20080153792A1 (en) * 2006-11-17 2008-06-26 Frincke James M Drug Identification and Treatment Method
US8217025B2 (en) * 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
US8486926B2 (en) * 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
US8354396B2 (en) * 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
US20080221074A1 (en) * 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
WO2009026473A2 (en) * 2007-08-21 2009-02-26 Hollis-Eden Pharmaceuticals, Inc. Stabilized therapeutic compositions and formulations
US20100261689A1 (en) * 2007-10-29 2010-10-14 Masuo Yamaoka Pyrrolo [1,2-c] imidazole derivatives for use in the prophylaxis or treatment of cancer which is refractory to known cancer therapies
US20100227841A1 (en) * 2008-09-24 2010-09-09 Harbor BioSciencs, Inc. Patient populations and treatment methods
US20100222315A1 (en) * 2008-09-24 2010-09-02 Harbor BioSciencs, Inc. Patient populations and treatment methods
WO2010036822A1 (en) * 2008-09-24 2010-04-01 Hollis-Eden Pharmaceuticals, Inc. Patient populations and treatment methods
WO2011066582A1 (en) * 2009-11-30 2011-06-03 Harbor Biosciences, Inc. Anticancer compounds and screening method
US20120214987A1 (en) * 2010-12-15 2012-08-23 Yu Ge Methods and compounds for preparing 3alpha-oxygen substituted steroids
RU2639147C1 (ru) * 2017-05-24 2017-12-20 Общество с ограниченной ответственностью "Пробиосинтез" Способ получения 17,17-этилендиоксиандроста-1,4-диен-3-она
WO2022198191A1 (en) * 2021-03-15 2022-09-22 Trustees Of Dartmouth College Androgen receptor modulators
CN113896756B (zh) * 2021-10-11 2023-01-03 浙江仙琚制药股份有限公司 一种1α-羟基去氢表雄酮的制备方法

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PT1955700E (pt) * 1999-09-30 2011-05-04 Harbor Biosciences Inc Tratamento terap?utico de doen?as associadas ao receptor de androg?nios
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US20060154909A1 (en) * 2004-07-21 2006-07-13 Kneller Bruce W 1,4,6-androstatriene-3,17-dione ("ATD") for therapeutic uses

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Also Published As

Publication number Publication date
US20080004250A1 (en) 2008-01-03
US7462610B2 (en) 2008-12-09
US20090176752A1 (en) 2009-07-09
US20110028711A1 (en) 2011-02-03
WO2004089304A2 (en) 2004-10-21
US7842680B2 (en) 2010-11-30
US20080009472A1 (en) 2008-01-10
US20080070881A1 (en) 2008-03-20
CA2522784A1 (en) 2004-10-21
US7638509B2 (en) 2009-12-29
EP1615944A2 (de) 2006-01-18
US7514420B2 (en) 2009-04-07
WO2004089304A3 (en) 2005-05-06
US7550450B2 (en) 2009-06-23
US20090181936A1 (en) 2009-07-16
CA2522784C (en) 2012-06-19
US20040242618A1 (en) 2004-12-02

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