EP1613732A4 - Complexes intracellulaires utilises comme biomarqueurs - Google Patents

Complexes intracellulaires utilises comme biomarqueurs

Info

Publication number
EP1613732A4
EP1613732A4 EP20040758577 EP04758577A EP1613732A4 EP 1613732 A4 EP1613732 A4 EP 1613732A4 EP 20040758577 EP20040758577 EP 20040758577 EP 04758577 A EP04758577 A EP 04758577A EP 1613732 A4 EP1613732 A4 EP 1613732A4
Authority
EP
European Patent Office
Prior art keywords
biomarkers
intracellular complexes
intracellular
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20040758577
Other languages
German (de)
English (en)
Other versions
EP1613732A2 (fr
Inventor
Sharat Singh
M Youssouf Badal
Xuenguang Jin
Hossein Salimi-Moosavi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Monogram Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/623,057 external-priority patent/US7105308B2/en
Application filed by Monogram Biosciences Inc filed Critical Monogram Biosciences Inc
Publication of EP1613732A2 publication Critical patent/EP1613732A2/fr
Publication of EP1613732A4 publication Critical patent/EP1613732A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP20040758577 2003-04-01 2004-03-30 Complexes intracellulaires utilises comme biomarqueurs Withdrawn EP1613732A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US45988803P 2003-04-01 2003-04-01
US10/623,057 US7105308B2 (en) 2002-07-25 2003-07-17 Detecting receptor oligomerization
US49448203P 2003-08-11 2003-08-11
US50803403P 2003-10-01 2003-10-01
US51294103P 2003-10-20 2003-10-20
US52325803P 2003-11-18 2003-11-18
PCT/US2004/009805 WO2004087887A2 (fr) 2003-04-01 2004-03-30 Complexes intracellulaires utilises comme biomarqueurs

Publications (2)

Publication Number Publication Date
EP1613732A2 EP1613732A2 (fr) 2006-01-11
EP1613732A4 true EP1613732A4 (fr) 2012-03-14

Family

ID=33136354

Family Applications (3)

Application Number Title Priority Date Filing Date
EP20040758577 Withdrawn EP1613732A4 (fr) 2003-04-01 2004-03-30 Complexes intracellulaires utilises comme biomarqueurs
EP04759065A Withdrawn EP1613961A4 (fr) 2003-04-01 2004-03-30 Complexes de recepteurs de surface utilises comme biomarqueurs
EP04759064.1A Expired - Lifetime EP1613205B1 (fr) 2003-04-01 2004-03-30 Complexes de recepteurs de surface erbb utilises comme biomarqueurs

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP04759065A Withdrawn EP1613961A4 (fr) 2003-04-01 2004-03-30 Complexes de recepteurs de surface utilises comme biomarqueurs
EP04759064.1A Expired - Lifetime EP1613205B1 (fr) 2003-04-01 2004-03-30 Complexes de recepteurs de surface erbb utilises comme biomarqueurs

Country Status (6)

Country Link
EP (3) EP1613732A4 (fr)
JP (2) JP2006521821A (fr)
AU (3) AU2004229348A1 (fr)
BR (3) BRPI0408928A (fr)
CA (3) CA2521106A1 (fr)
WO (3) WO2004092353A2 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
CA2521106A1 (fr) * 2003-04-01 2004-10-14 Monogram Biosciences, Inc. Complexes intracellulaires utilises comme biomarqueurs
BRPI0413471A (pt) 2003-08-11 2006-10-17 Monogram Biosciences Inc métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica
US7402399B2 (en) * 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
ATE520988T1 (de) * 2004-09-22 2011-09-15 Tripath Imaging Inc Verfahren und zusammensetzungen zur bewertung einer brustkrebsprognose
US7700299B2 (en) * 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
EP2008102A4 (fr) * 2006-04-18 2009-07-08 Wellstat Biologics Corp Detection de proteines dans des cellules neoplastiques en circulation
CA2663595A1 (fr) * 2006-08-07 2008-02-14 The Board Of Regents Of The University Of Texas System Schemas proteomiques de pronostic du cancer et signatures predictives
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
WO2011008990A1 (fr) 2009-07-15 2011-01-20 Prometheus Laboratories Inc. Sélection de médicaments pour la thérapie d’un cancer gastrique au moyen de réseaux à base d’anticorps
WO2008064884A1 (fr) 2006-11-28 2008-06-05 U3 Pharma Gmbh Her3 activé servant de marqueur pour prédire l'efficacité thérapeutique
EP2647388A1 (fr) 2007-02-16 2013-10-09 Merrimack Pharmaceuticals, Inc. Anticorps dirigés contre l'ERBB3 et leurs utilisations
JP5352585B2 (ja) * 2007-07-13 2013-11-27 ネステク ソシエテ アノニム 抗体アレイを用いた肺癌治療のための薬剤選択
WO2009086197A1 (fr) 2007-12-20 2009-07-09 Monogram Biosciences, Inc. Procédés de diagnostic du her-2
CN103399144B (zh) 2008-02-25 2015-10-28 雀巢产品技术援助有限公司 用抗体阵列选择乳腺癌治疗药物
US8168755B2 (en) * 2008-05-07 2012-05-01 Eutropics Pharmaceuticals, Inc. Antibodies specific to heterodimers of Bcl-2 family and uses thereof
PE20120015A1 (es) * 2008-08-15 2012-01-26 Merrimack Pharmaceuticals Inc Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico
SG177252A1 (en) 2008-12-01 2012-03-29 Lab Corp America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
WO2010083463A1 (fr) * 2009-01-15 2010-07-22 Laboratory Corporation Of America Holdings Procédés de détermination d'une réponse de patient par la mesure de l'expression de her-2
EP2387711B1 (fr) 2009-01-15 2015-04-22 Laboratory Corporation of America Holdings Procédés permettant de déterminer la réponse d'un patient par mesure de her-3
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
JP5923035B2 (ja) 2009-03-24 2016-05-24 バイオセプト インコーポレイティッド 細胞の捕捉および解析のデバイスおよび方法
CA2761777A1 (fr) 2009-05-14 2010-11-18 Prometheus Laboratories Inc. Biomarqueurs permettant de determiner la sensibilite de cellules cancereuses du sein a un traitement ciblant le recepteur her2
CN105999263B (zh) 2009-11-13 2021-06-29 第一三共欧洲有限公司 用于治疗或预防人表皮生长因子受体-3(her-3)相关疾病的材料和方法
DK2544680T3 (en) 2010-03-11 2015-04-27 Merrimack Pharmaceuticals Inc USE OF ErbB3 INHIBITORS IN TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2012135695A2 (fr) * 2011-03-30 2012-10-04 The Uab Research Foundation Modulation de migration cellulaire
ES2553456T3 (es) * 2011-09-02 2015-12-09 Nestec S.A. Perfilado de proteínas de ruta de señal para determinar una eficacia terapéutica
US20150150869A1 (en) 2012-06-20 2015-06-04 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
US20160038503A1 (en) 2012-11-21 2016-02-11 David Richard Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
US20160041171A1 (en) * 2013-04-05 2016-02-11 Laboratory Corporation Of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
KR20160009070A (ko) * 2013-05-21 2016-01-25 네스텍 소시에테아노님 대장암 환자의 생존율 예측 및 개선 방법
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
US10640803B2 (en) 2013-10-30 2020-05-05 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
WO2015100459A2 (fr) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Profils de biomarqueur pour prédire les résultats d'une thérapie cancéreuse utilisant des inhibiteurs d'erbb3 et/ou des chimiothérapies
CN107406881B (zh) 2015-01-12 2021-05-25 尤特罗皮克斯制药股份有限公司 用于指导癌症治疗的内容相关的诊断测试
US20190041389A1 (en) * 2015-02-13 2019-02-07 The University Of Queensland Methods for classifying tumors and uses therefor
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
EP3403095B1 (fr) 2016-03-15 2019-08-07 Laboratory Corporation of America Holdings Procédés d'évaluation d'interactions de protéines entre des cellules
EP3715844A4 (fr) * 2017-11-20 2021-04-14 Konica Minolta, Inc. Procédé d'évaluation de médicament
IT201800008274A1 (it) * 2018-08-31 2020-03-02 Alifax Srl Metodo immunometrico per analisi cliniche biologiche

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024205A1 (fr) * 1994-03-07 1995-09-14 New York University Medical Center Procede et compositions de traitement du cancer du sein
WO2003068808A1 (fr) * 2002-02-13 2003-08-21 Garvan Institute Of Medical Research Nouveaux complexes proteiques et utilisations associees
WO2003076649A1 (fr) * 2002-03-05 2003-09-18 Aclara Biosciences, Inc. Analyse multiplex au moyen de sensibilisateurs fixes a une membrane
WO2004091384A2 (fr) * 2003-04-01 2004-10-28 Monogram Biosciences, Inc. Complexes de recepteurs de surface erbb utilises comme biomarqueurs
WO2005037071A2 (fr) * 2003-10-14 2005-04-28 Monogram Biosciences, Inc. Analyse de la voie de signalisation de la tyrosine kinase de recepteur pour diagnostic et therapie

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597531A (en) 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
DK0653066T3 (da) 1992-07-31 1998-09-23 Dade Behring Marburg Gmbh Fotoaktiverbare kemiluminescerende matricer
US5811098A (en) 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US5693271A (en) 1994-09-01 1997-12-02 Chase Industries, Inc. Rotationally molding an insulated plastic molded door with integral hinge
US5599631A (en) 1995-03-08 1997-02-04 Eastman Kodak Company Fluorinated elastomer/fluorinated resin compositions for toner fusing members
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
US6417168B1 (en) * 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
US6095661A (en) 1998-03-19 2000-08-01 Ppt Vision, Inc. Method and apparatus for an L.E.D. flashlight
WO2000014105A1 (fr) * 1998-09-08 2000-03-16 Agouron Pharmaceuticals, Inc. Modification de la proteine recepteur 2 de vegf et ses methodes d'utilisation
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US6346384B1 (en) 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
EP1305632B1 (fr) 2000-05-04 2011-07-27 Siemens Healthcare Diagnostics Products GmbH Methodes servant a la detection d'analytes multiples
US6547654B2 (en) 2000-07-22 2003-04-15 Americo Del Raso Automatic abrasive sleeve tightening means and quick release system for an oscillating spindle sander
US20020127654A1 (en) * 2001-02-22 2002-09-12 Price Virginia L. Compositions and methods for production cell culture
CZ20033143A3 (en) 2001-05-21 2004-04-14 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
AU2002316577A1 (en) 2001-07-09 2003-01-29 Aclara Biosciences, Inc. Cell-screening assay and composition
CA2354690A1 (fr) 2001-07-20 2001-10-27 Jan Prinzmetal Tapis
US6545102B1 (en) * 2001-09-27 2003-04-08 Lumigen, Inc. Polymer-supported photosensitizers
US7910314B2 (en) * 2002-03-01 2011-03-22 Roger Williams Hospital Shc protein-related methods and compositions for the prognosis of breast, prostate and ovarian cancer
PL214010B1 (pl) * 2002-07-15 2013-06-28 Genentech Inc Rekombinowane humanizowane przeciwcialo 2C4 i zastosowanie tego przeciwciala
ATE442589T1 (de) 2002-07-25 2009-09-15 Aclara Biosciences Inc Nachweis der rezeptoroligomerisierung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024205A1 (fr) * 1994-03-07 1995-09-14 New York University Medical Center Procede et compositions de traitement du cancer du sein
WO2003068808A1 (fr) * 2002-02-13 2003-08-21 Garvan Institute Of Medical Research Nouveaux complexes proteiques et utilisations associees
WO2003076649A1 (fr) * 2002-03-05 2003-09-18 Aclara Biosciences, Inc. Analyse multiplex au moyen de sensibilisateurs fixes a une membrane
WO2004091384A2 (fr) * 2003-04-01 2004-10-28 Monogram Biosciences, Inc. Complexes de recepteurs de surface erbb utilises comme biomarqueurs
WO2005037071A2 (fr) * 2003-10-14 2005-04-28 Monogram Biosciences, Inc. Analyse de la voie de signalisation de la tyrosine kinase de recepteur pour diagnostic et therapie

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO2004087887A2 *
SHINODA SACHIKO ET AL: "Interaction of 14-3-3 with Bid during seizure-induced neuronal death.", JOURNAL OF NEUROCHEMISTRY, vol. 86, no. 2, July 2003 (2003-07-01), pages 460 - 469, XP002667074, ISSN: 0022-3042 *
ZHA J ET AL: "Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL", CELL, CELL PRESS, US, vol. 87, 15 November 1996 (1996-11-15), pages 619 - 628, XP002110634, ISSN: 0092-8674, DOI: 10.1016/S0092-8674(00)81382-3 *

Also Published As

Publication number Publication date
BRPI0408961A (pt) 2006-10-31
CA2521077A1 (fr) 2004-10-28
WO2004091384A3 (fr) 2005-12-29
EP1613961A4 (fr) 2007-03-07
EP1613205B1 (fr) 2013-04-24
AU2004230700A1 (en) 2004-10-28
JP2006523314A (ja) 2006-10-12
AU2004225439A1 (en) 2004-10-14
CA2521106A1 (fr) 2004-10-14
EP1613205A2 (fr) 2006-01-11
BRPI0408928A (pt) 2006-09-12
CA2521082A1 (fr) 2004-10-28
WO2004092353A3 (fr) 2005-03-03
AU2004229348A1 (en) 2004-10-28
EP1613205A4 (fr) 2006-11-29
BRPI0408950A (pt) 2006-03-28
EP1613732A2 (fr) 2006-01-11
WO2004092353A2 (fr) 2004-10-28
WO2004087887A2 (fr) 2004-10-14
EP1613961A2 (fr) 2006-01-11
JP2006521821A (ja) 2006-09-28
WO2004087887A3 (fr) 2006-06-15
WO2004091384A2 (fr) 2004-10-28

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