BRPI0408961A - método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente - Google Patents

método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente

Info

Publication number
BRPI0408961A
BRPI0408961A BRPI0408961-8A BRPI0408961A BRPI0408961A BR PI0408961 A BRPI0408961 A BR PI0408961A BR PI0408961 A BRPI0408961 A BR PI0408961A BR PI0408961 A BRPI0408961 A BR PI0408961A
Authority
BR
Brazil
Prior art keywords
patient
determining
condition
erbb
cancer
Prior art date
Application number
BRPI0408961-8A
Other languages
English (en)
Inventor
Po-Ying Chan-Hui
Hossein Salimi-Moosavi
Yining Shi
Sharat Singh
Rajiv Dua
Ali Mukher-Jee
Sailaja Pidaparthi
Original Assignee
Monogram Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/623,057 external-priority patent/US7105308B2/en
Application filed by Monogram Biosciences Inc filed Critical Monogram Biosciences Inc
Publication of BRPI0408961A publication Critical patent/BRPI0408961A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODO PARA DETERMINAR UMA SITUAçãO DE DOENçA DE UM PACIENTE, MéTODO PARA SELECIONAR UM PACIENTE PARA TRATAMENTO DE UM CáNCER COM UM OU MAIS MEDICAMENTOS DE AçãO DIMéRICA DE ERBB, E, MéTODO PARA DETERMINAR UMA SITUAçãO CANCEROSA DE UM PACIENTE". A invenção está direcionada a uma nova classe de biomarcador em amostras de paciente que compreende dímeros de receptores de membrana de superfície celular de ErbB. Em um aspecto, a invenção inclui um método para determinar uma situação de uma doença ou condição saudável correlacionando-se tal condição com as quantidades de um ou mais dímeros de receptores de membrana de superfície celular de ErbB medidas diretamente em uma amostra do paciente, em particular uma amostra de tecido fixa. Em um outro aspecto, a invenção inclui um método para determinar uma situação de um câncer em um espécime de um indivíduo correlacionando-se medições de quantidades de um ou mais dímeros de receptores de membrana de superfície celular de ErbB nas células do espécime para tal situação, incluindo a presença ou ausência de um estado pré canceroso, presença ou ausência de um estado canceroso, prognóstico de um câncer ou responsividade ao tratamento. Preferivelmente, os métodos da invenção são implementados usando-se conjuntos de compostos de ligação tendo rótulos moleculares liberáveis que são específicos para componentes múltiplos de um ou mais tipos de dímeros receptores. Depois da ligação, os rótulos moleculares são liberados e separados da mistura de ensaio para análise.
BRPI0408961-8A 2003-04-01 2004-03-30 método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente BRPI0408961A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US45988803P 2003-04-01 2003-04-01
US10/623,057 US7105308B2 (en) 2002-07-25 2003-07-17 Detecting receptor oligomerization
US49448203P 2003-08-11 2003-08-11
US50803403P 2003-10-01 2003-10-01
US51294103P 2003-10-20 2003-10-20
US52325803P 2003-11-18 2003-11-18
PCT/US2004/009715 WO2004091384A2 (en) 2003-04-01 2004-03-30 Erbb surface receptor complexes as biomarkers

Publications (1)

Publication Number Publication Date
BRPI0408961A true BRPI0408961A (pt) 2006-10-31

Family

ID=33136354

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0408961-8A BRPI0408961A (pt) 2003-04-01 2004-03-30 método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente
BRPI0408928-6A BRPI0408928A (pt) 2003-04-01 2004-03-30 métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente
BRPI0408950-2A BRPI0408950A (pt) 2003-04-01 2004-03-30 método para determinar a situação de doença de um paciente, e, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica

Family Applications After (2)

Application Number Title Priority Date Filing Date
BRPI0408928-6A BRPI0408928A (pt) 2003-04-01 2004-03-30 métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente
BRPI0408950-2A BRPI0408950A (pt) 2003-04-01 2004-03-30 método para determinar a situação de doença de um paciente, e, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica

Country Status (6)

Country Link
EP (3) EP1613961A4 (pt)
JP (2) JP2006521821A (pt)
AU (3) AU2004230700A1 (pt)
BR (3) BRPI0408961A (pt)
CA (3) CA2521077A1 (pt)
WO (3) WO2004091384A2 (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
AU2004230700A1 (en) * 2003-04-01 2004-10-28 Monogram Biosciences, Inc. Surface receptor complexes as biomarkers
BRPI0413471A (pt) * 2003-08-11 2006-10-17 Monogram Biosciences Inc métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica
US7402399B2 (en) * 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
BRPI0515581A (pt) * 2004-09-22 2008-07-29 Tripath Imaging Inc métodos e produtos de programa de computador para análise e otimização de candidatos marcadores para prognóstico de cáncer
US7700299B2 (en) 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
CA2647843A1 (en) * 2006-04-18 2007-10-25 Wellstat Biologics Corporation Detection of proteins from circulating neoplastic cells
CA2663595A1 (en) * 2006-08-07 2008-02-14 The Board Of Regents Of The University Of Texas System Proteomic patterns of cancer prognostic and predictive signatures
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
AU2007324868B2 (en) 2006-11-28 2014-03-20 Daiichi Sankyo Europe Gmbh Activated HER3 as a marker for predicting therapeutic efficacy
PT2716301T (pt) 2007-02-16 2017-07-04 Merrimack Pharmaceuticals Inc Anticorpos contra erbb3 e suas utilizações
CN101802618B (zh) * 2007-07-13 2015-02-25 雀巢产品技术援助有限公司 利用基于抗体的阵列选择肺癌治疗药物
EP2235536A4 (en) 2007-12-20 2011-05-04 Lab Corp America Holdings HER-2 DIAGNOSTIC METHODS
NZ617520A (en) 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
US8168755B2 (en) * 2008-05-07 2012-05-01 Eutropics Pharmaceuticals, Inc. Antibodies specific to heterodimers of Bcl-2 family and uses thereof
UA104868C2 (uk) * 2008-08-15 2014-03-25 Меррімак Фармасьютікалз, Інк. Спосіб лікування пацієнта, що має неопластичну пухлину, відповідно до спрогнозованої реакції
CA2764386C (en) 2008-12-01 2018-05-01 Laboratory Corporation Of America Holdings P95-her2 antibodies and uses thereof
SG172983A1 (en) 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-3
CN102439452B (zh) * 2009-01-15 2015-04-15 美国控股实验室公司 通过测量her-2表达确定患者应答的方法
AU2010229924B2 (en) 2009-03-24 2016-07-21 Biocept, Inc. Devices and methods of cell capture and analysis
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
NZ596468A (en) 2009-05-14 2013-11-29 Nestec Sa Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy
AU2010273319B2 (en) 2009-07-15 2015-01-22 Nestec S.A. Drug selection for gastric cancer therapy using antibody-based arrays
PT3351558T (pt) 2009-11-13 2020-04-09 Daiichi Sankyo Europe Gmbh Material e métodos para tratamento ou prevenção de doenças associadas a her-3
US8895001B2 (en) 2010-03-11 2014-11-25 Merrimack Pharmaceuticals, Inc. Use of ErbB3 inhibitors in the treatment of triple negative and basal-like breast cancers
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
US20140248291A1 (en) * 2011-03-30 2014-09-04 The Uab Research Foundation Modulation of Cellular Migration
KR101851425B1 (ko) * 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
EP2863920B1 (en) 2012-06-20 2023-03-22 Eutropics Pharmaceuticals, Inc. Quinoline derivatives for use in the tratment of breast cancer
US20160038503A1 (en) 2012-11-21 2016-02-11 David Richard Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
US20160041171A1 (en) * 2013-04-05 2016-02-11 Laboratory Corporation Of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
SG11201509367RA (en) * 2013-05-21 2015-12-30 Nestec Sa Methods for predicting and improving the survival of colorectal cancer patients
WO2015017788A1 (en) 2013-08-01 2015-02-05 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
JP6538044B2 (ja) 2013-10-30 2019-07-03 ユートロピクス ファーマシューティカルズ， インコーポレイテッド 化学療法感受性および化学毒性を判定する方法
WO2015100459A2 (en) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
WO2016115105A1 (en) 2015-01-12 2016-07-21 Eutropics Pharmaceuticals, Inc. Context dependent diagnostics test for guiding cancer treatment
WO2016127220A1 (en) * 2015-02-13 2016-08-18 The University Of Queensland Methods for classifying tumors and uses therefor
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
CN108780089B (zh) 2016-03-15 2020-09-08 美国控股实验室公司 评估细胞间的蛋白质相互作用的方法
US20200355694A1 (en) * 2017-11-20 2020-11-12 Konica Minolta, Inc. Drug Evaluation Method
IT201800008274A1 (it) * 2018-08-31 2020-03-02 Alifax Srl Metodo immunometrico per analisi cliniche biologiche

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5597531A (en) 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
JP3464798B2 (ja) 1992-07-31 2003-11-10 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 光活性化化学発光基質
US5811098A (en) 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US6037134A (en) * 1994-03-07 2000-03-14 New York University Medical Center Methods that detect compounds that disrupt receptor tyrosine kinase/GRB-7 complexes
US5693271A (en) 1994-09-01 1997-12-02 Chase Industries, Inc. Rotationally molding an insulated plastic molded door with integral hinge
US5599631A (en) 1995-03-08 1997-02-04 Eastman Kodak Company Fluorinated elastomer/fluorinated resin compositions for toner fusing members
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
US6417168B1 (en) * 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
US6095661A (en) 1998-03-19 2000-08-01 Ppt Vision, Inc. Method and apparatus for an L.E.D. flashlight
ES2252972T3 (es) * 1998-09-08 2006-05-16 Agouron Pharmaceuticals, Inc. Modificaciones de la proteina vegfr-2 y procedimiento de uso.
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6627400B1 (en) * 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US6346384B1 (en) 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
JP4796259B2 (ja) 2000-05-04 2011-10-19 シーメンス・ヘルスケア・ダイアグノスティックス・プロダクツ・ゲーエムベーハー 複数のアナライトの検出において使用するための組成物
US6547654B2 (en) 2000-07-22 2003-04-15 Americo Del Raso Automatic abrasive sleeve tightening means and quick release system for an oscillating spindle sander
WO2002068668A2 (en) * 2001-02-22 2002-09-06 Immunex Corporation Compositions and methods for production cell culture
EP1506399A2 (en) 2001-05-21 2005-02-16 Aclara BioSciences, Inc. Methods and compositions for analyzing proteins
WO2003006947A2 (en) 2001-07-09 2003-01-23 Aclara Biosciences, Inc. Cell-screening assay and composition
CA2354690A1 (en) 2001-07-20 2001-10-27 Jan Prinzmetal Mat
US6545102B1 (en) * 2001-09-27 2003-04-08 Lumigen, Inc. Polymer-supported photosensitizers
WO2003068808A1 (en) * 2002-02-13 2003-08-21 Garvan Institute Of Medical Research Novel protein complexes and uses therefor
US7910314B2 (en) * 2002-03-01 2011-03-22 Roger Williams Hospital Shc protein-related methods and compositions for the prognosis of breast, prostate and ovarian cancer
AU2003222253A1 (en) 2002-03-05 2003-09-22 Monogram Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
PT2263691E (pt) * 2002-07-15 2012-11-12 Hoffmann La Roche Tratamento de cancro com o anticorpo anti-erbb2 monoclonal humanizado recombinante 2c4 (rhumab 2c4)
KR20050025669A (ko) * 2002-07-25 2005-03-14 아클라라 바이오사이언시스 인코퍼레이티드 수용체 올리고머화의 검출
AU2004230700A1 (en) * 2003-04-01 2004-10-28 Monogram Biosciences, Inc. Surface receptor complexes as biomarkers
US7402399B2 (en) * 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy

Also Published As

Publication number Publication date
AU2004230700A1 (en) 2004-10-28
CA2521106A1 (en) 2004-10-14
EP1613732A2 (en) 2006-01-11
AU2004225439A1 (en) 2004-10-14
WO2004087887A2 (en) 2004-10-14
CA2521077A1 (en) 2004-10-28
WO2004087887A3 (en) 2006-06-15
EP1613205B1 (en) 2013-04-24
EP1613205A4 (en) 2006-11-29
EP1613961A2 (en) 2006-01-11
EP1613205A2 (en) 2006-01-11
WO2004092353A3 (en) 2005-03-03
BRPI0408950A (pt) 2006-03-28
WO2004091384A3 (en) 2005-12-29
EP1613961A4 (en) 2007-03-07
CA2521082A1 (en) 2004-10-28
WO2004092353A2 (en) 2004-10-28
JP2006521821A (ja) 2006-09-28
EP1613732A4 (en) 2012-03-14
WO2004091384A2 (en) 2004-10-28
BRPI0408928A (pt) 2006-09-12
JP2006523314A (ja) 2006-10-12
AU2004229348A1 (en) 2004-10-28

Similar Documents

Publication Publication Date Title
BRPI0408961A (pt) método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente
Rice et al. A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis
Figueiredo et al. Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
Morabito et al. Effects of genistein and hormone‐replacement therapy on bone loss in early postmenopausal women: a randomized double‐blind placebo‐controlled study
Cabral et al. Mutations near amino end of α1 (I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing
Ukegawa et al. Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells
van Oosterwijk et al. Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFβ as potential targets
Chen et al. Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A/cAMP-response element binding protein signaling via a Gαs-mediated mechanism
Kazemi et al. VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans
WO2006044748A3 (en) RESPONSE PREDICTORS FOR ErbB PATHWAY-SPECIFIC DRUGS
WO2005037071A3 (en) Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
Bartsch et al. Nocturnal urinary 6‐sulphatoxymelatonin excretion is decreased in primary breast cancer patients compared to age‐matched controls and shows negative correlation with tumor‐size
Koizumi et al. Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells
Roberts et al. Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
BRPI0413471A (pt) métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica
Ramage et al. NMDA receptor expression and activity in osteoarthritic human articular chondrocytes
Nagano et al. The inhibitory effect of soybean and soybean isoflavone diets on 2, 4-dinitrofluorobenzene-induced contact hypersensitivity in mice
Jun et al. Expression of MET in alveolar soft part sarcoma
Lee et al. Raftlin: a new biomarker in human sepsis
US7105292B2 (en) Screening methods used to identify compounds that modulate a response of a cell to ultraviolet radiation exposure
US20230091848A1 (en) Disease detection and treatment based on phenylacetyl glutamine levels
Beetch et al. Subtle alterations in DNA methylation patterns in normal cells in response to dietary stilbenoids
WO2006044566A3 (en) Autocrine growth factor receptors and methods
Rambow et al. Identification of differentially expressed genes in spontaneously regressing melanoma using the MeLiM swine model
BR0209172A (pt) Método de detecção de doenças induzidas por glúten em uma amostra sanguìnea de um indivìduo, e kit teste para uso no método

Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 3A,4A,5A,6A E 7A ANUIDADE(S).

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.