EP1601342A1 - Darreichungsform und kit zur oralen verabreichung von wirkstoffen, vitaminen und/oder n ährstoffen - Google Patents
Darreichungsform und kit zur oralen verabreichung von wirkstoffen, vitaminen und/oder n ährstoffenInfo
- Publication number
- EP1601342A1 EP1601342A1 EP04710815A EP04710815A EP1601342A1 EP 1601342 A1 EP1601342 A1 EP 1601342A1 EP 04710815 A EP04710815 A EP 04710815A EP 04710815 A EP04710815 A EP 04710815A EP 1601342 A1 EP1601342 A1 EP 1601342A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- dosage form
- locking device
- form according
- drinking straw
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0038—Straws
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47G—HOUSEHOLD OR TABLE EQUIPMENT
- A47G21/00—Table-ware
- A47G21/18—Drinking straws or the like
- A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid
Definitions
- the invention relates to a dosage form for oral administration of active ingredients, vitamins and / or nutrients, comprising a drinking straw with an impermeable formulation for an active ingredient, vitamin and / or nutrient, but permeable and essentially permeable to air and a transport liquid within the drinking straw only in the suction direction slidable locking device, the sliding surfaces are designed so that the movement of the locking device against the suction direction is at least difficult, as well as a kit of the dosage form and a transport liquid.
- the drinking straws known from the prior art for the oral administration of active substances, vitamins and / or nutrients do not offer the possibility of reliably checking the complete consumption of the active substance formulation. Because of the large number of medications to be administered, it is not possible for nursing staff in hospitals or nursing homes to continuously monitor their medication intake. A simple control of the complete intake of a drug from the drinking straw is therefore desirable.
- a dosage form for the oral administration of active ingredients, vitamins and / or nutrients comprising a drinking straw, the two Has openings and a locking device for a drug, vitamin and / or nutrient formulation impermeable, but permeable to air and a transport liquid and slidable in the suction direction, which is characterized in that at least part of the sliding surface of the locking device is designed so that the movement of the locking device against the suction direction is at least difficult.
- the complete removal or ingestion of the formulation containing the active substance, vitamins and / or nutrients is indicated by the fact that a lubricating blocking device permanently changes its position within the drinking straw in accordance with the ingestion.
- the dosage form according to the invention thereby makes it possible to determine the ingestion, preferably the complete ingestion of a formulation by the position of the blocking device.
- the blocking device is located at the end of the drinking straw which has the opening facing the mouth.
- the spinning device which is slidable in the suction direction and largely blocked in the opposite direction is suitable for permitting a transport liquid and air, but not the active substance, vitamin and / or nutrient formulation, to pass through in the drinking straw.
- the dispensing device can preferably only be moved in the suction direction.
- the sliding surface of the locking device is at least partially designed in such a way that movement against the suction direction is at least made more difficult, preferably even prevented overall. This makes it possible to show the respective removal of the formulation in accordance with the changed position of the locking device.
- the change in position is carried out by sucking transport liquid through the drinking straw, whereby the locking device according to the invention and the formulation are transported.
- the design of the sliding surface for blocking the blocking device is of a regular arrangement with uniform blocking structures, such as, for. B. scales, saw teeth or pyramidal structures.
- the sliding surfaces of the locking device are essentially modeled on the surface of a shark skin.
- shark skin is characterized by a large number of pyramidal structures which are directed and preferably flattened in the direction opposite to the preferred direction of movement (suction direction), as a result of which particularly good flow properties are achieved.
- suction direction preferred direction of movement
- This surface structure is preferably present over the entire circumference of the locking device.
- the sliding surfaces of the locking device at least partially have a scale structure, preferably similar to a fish skin or the sliding surfaces of cross-country skis.
- the scales particularly preferably have a straight end edge that faces the suction direction, runs essentially perpendicular to the suction direction, and an opposite end edge that runs essentially semicircularly.
- These scales can be arranged diagonally offset from one another or one behind the other.
- the scales are arranged on the sliding surfaces in such a way that the substantially semicircular terminating edge of a first scale is arranged above the straight terminating edge of a second scale that is perpendicular to the suction direction.
- This structure is preferably found over the entire circumference of the locking device.
- the resulting rows of scales are arranged essentially perpendicular to the suction direction.
- Such a structuring of the surface of the locking device creates a controllable form of administration, since sliding the locking device in the suction direction supports the sliding device without any appreciable reduction in the diameter, and its sliding back is practically prevented after the suction process has stopped.
- the sliding surfaces of the locking device have saw teeth, at least partially in a regular arrangement, the bevel of which is essentially opposite to the direction of suction is aligned. In the opposite direction, however, there is preferably no beveling of the saw teeth, but rather an essentially right-angled transition from the sliding surface of the locking device to the individual saw teeth, in particular when at least these saw teeth are made of relatively rigid material. If the saw teeth are made of a relatively elastic material so that they assume the configuration described above when inserted into the drinking straw due to the corresponding diameter of the locking device, the saw teeth need not have a different bevel.
- this design of the sliding surfaces extends over the entire circumference of the locking device.
- the person skilled in the art understands that the configuration of saw teeth running over the entire circumference of the blocking device preferably results in rows arranged one above the other and bevelled against the suction direction, which are arranged essentially perpendicular to the suction direction.
- the designs set out above only extend over the entire circumference, but only over a partial surface of the sliding surfaces of the locking device.
- this surface design is realized in segments of the sliding surface which are preferably distributed uniformly over the circumference of the sliding surfaces.
- the material of the sliding surface is preferably the same as that of the rest of the locking device.
- the material preferably has sufficient elasticity to allow the surface structure to be in contact with suction and at the same time to allow the surface structure to spring back.
- Plastics, synthetic or natural, which can also be foamed, are suitable for this. This creates a locking device that has a particularly low weight.
- the use of such dosage forms according to the invention is also possible for particularly weakened patients without increased physical exertion.
- the blocking devices with the surface structures according to the invention can be produced by extrusion and / or injection molding or mechanical surface processing such as embossing.
- the blocking device can preferably also consist of filter material, particularly preferably of non-woven material or pressed fiber material.
- the locking device is thus comparable to a cigarette filter.
- a surface structure according to the invention can be produced, for example, by coating such a blocking device with a plastic film, preferably a tubular film, which already has a correspondingly designed surface structure.
- such a blocking device is connected to a structured film according to the invention by means of an adhesive which is not harmful to food law. This lamination can be carried out continuously or discontinuously on the semi-finished product or on the individual product.
- the surface film preferably has the embossing according to the invention.
- the blocking device preferably has continuous channels so that the transport liquid not only flows around the blocking device but can also flow through it.
- This design of the locking device can be chosen according to the weight of the locking device. It is important to ensure that the opening of the channels does not allow passage of a particular formulation or any other form of formulation.
- the dimensions of the locking device are adapted to the dimension of the drinking straw, with a round drinking straw the diameter of the locking device being adapted to the inside diameter of the drinking straw, taking into account the surface design of the locking device.
- the locking device is preferably cylindrical, particularly preferably a plug.
- the locking device can be moved between a stop at the opening that is not the mouth opening and the suction opening (mouth opening).
- a further stop is arranged in the direct vicinity of the mouth opening.
- the drinking straw is narrowed by the stops, the narrowings being designed such that the blocking device, but not the formulation particles which may be insoluble in the transport liquid, are retained.
- the drinking straw can be rigid or flexible, straight or angled and / or reversibly angled.
- the drinking straw is preferably constructed from a synthetic material.
- the drinking straw has two essentially straight legs connected to one another via a curvature and / or a means for curvature.
- the means for curvature is reversible.
- the locking device and the formulation are arranged in the leg with the mouth opening between the curvature and the mouth opening. This creates a device that is particularly easy to store and at the same time makes it easier for lying patients to take the formulation.
- the drinking straw preferably has a transparent outer wall, at least in the region of the opening facing the patient.
- the transparent outer wall extends over a partial circumference of the drinking straw. This will create a
- Dosage form created that allows to control the position of the locking device and thus the extent to which the formulation is taken.
- the inside diameter of the drinking straw should preferably be at least 3 mm, as a result of which a sufficient amount of transport liquid can be drawn through the drinking straw in order to transport the locking device and the formulation.
- An inner diameter of 3-20 mm is preferred, particularly preferably 4-15 mm, very particularly preferably 5-10 mm.
- the drinking straw opening to which the active ingredient, vitamin and / or nutrient formulation and the blocking device can be transported largely unhindered, is preferably designed as a mouthpiece, particularly preferably corrugated, while the other opening is preferably used as a connection piece to a reservoir Transport liquid can be formed.
- the drinking straw preferably has a marking to identify the mouth part and / or to indicate the direction of suction of the transport liquid. This marking makes handling easier.
- At least one of the openings of the drinking straw has a removable closure.
- the closure is a cap or a preferably removable lock made of a membrane or film.
- the active substance, vitamin and / or nutrient formulation is preferably solid or pasty at the storage temperature of the system according to the invention, preferably at 25 ° C.
- a multiparticulate formulation of active substance, vitamin and / or nutrient is preferred, the formulation being particularly preferably in the form of particles, preferably solid particles.
- the active substances, vitamins and / or nutrients alone or the active substance, vitamin and / or nutrient formulations as a whole can be soluble or insoluble in the transport liquid.
- the active ingredients, vitamins and / or nutrients or their formulations as a whole are soluble in the transport liquid, they are dissolved by the sucked-in transport liquid and taken away in dissolved form. If, on the other hand, the active substances, vitamins and / or nutrients or their formulations as a whole are insoluble in the transport liquid, they are only conveyed on by the transport liquid drawn in. Multiparticulate formulations are preferably used.
- the particles should have dimensions such that they can easily be transported out of the drinking straw by sucking in the transport liquid. Adhesion of the particles to one another or to the walls of the drinking straw should be excluded, which can be achieved if necessary by suitable surface treatment of the particles.
- the particles preferably have a diameter in the range of 100-1500 ⁇ m, preferably 150-800 ⁇ m.
- the formulation can also be in tablet form. All orally administrable substances can be used as active substances, preferably therapeutic active substances, vitamins or nutrients, provided that a suitable formulation for the system according to the invention is possible.
- the dosage form preferably contains a precisely determined dose of these substances, which is approved or tolerated for administration to humans and animals, preferably humans.
- Therapeutic agents are not to be understood as nicotines, such as levo-nicotine, dextro-nicotine, their racemic mixtures and / or pharmaceutical salts.
- the active ingredient, vitamin and / or nutrient formulation is arranged according to the invention within the drinking straw in the direction of suction of the transport liquid between the blocking device and the mouth opening of the drinking straw.
- the active substance, vitamin and / or nutrient formulation can also be immobilized in the drinking straw and can only be mobilized by contact with the transport liquid.
- the formulation can preferably be immobilized with the aid of sugars and / or sugar-like compounds, preferably sucrose, glucose, fructose, mannitol, sorbitol, flucose, maltose, lactose, galactose, trehalose and / or sugar alcohols, cyclic sugars, preferably cyclodextrins, of proteins , preferably gelatins, gelatin derivatives, gelatin hydroxylates, dextrins, proteins from soybean, wheat and / or psyllium seeds, from rubber and / or rubber-like materials, preferably agar, acacia, guar, xanthan, from starch, preferably starch consisting of amylose with up to 6000 glucose units and amylopectin with 10-60 glucose units, of modified starch, preferably starch with esterified hydroxyl groups, hydroxyethyl starch, hydroxypropyl starch and / or distarch phosphates, of pe
- a carrier used for immobilization preferably consists of a cotton-like plug of sugar, preferably sucrose, glucose, fructose, mannitol, sorbitol, flucose, lactose and / or maltose, made of a soluble cellulose material, preferably methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose and / or an alkali metal salt of carboxymethyl cellulose, or mixtures thereof.
- the blocking device is arranged between the curvature area and the mouth opening of the drinking straw and can be moved there and positioned between the curvature area of the drinking straw and its mouth opening before the formulation is removed.
- an additional closure device is arranged within the drinking straw.
- the closure device is preferably used to prevent a non-immobilized formulation from falling out of the drinking straw before use of the dosage form according to the invention.
- the closure device according to the invention is arranged in the suction direction of the transport liquid between the active substance, vitamin and / or nutrient formulation and the mouth opening of the drinking straw and preferably consists of a physiologically acceptable material that is soluble in the transport liquid.
- a closure device particularly preferably consists of materials from which the above-described carrier for immobilization can be made.
- the closure device can also serve as a carrier for immobilizing active substances, vitamins and / or nutrients.
- the opening of the drinking straw which the active ingredient, vitamin and / or nutrient formulation faces, can be provided with a closure.
- the closure is preferably a cap or stopper, which is preferably removed immediately prior to oral administration.
- the closure is a closure which closes at least the drinking straw opening which faces the formulation and which is impermeable to the active ingredient, vitamin and / or nutrient formulation before administration from an at least partially removable and / or destructible, foil attached to the straw opening.
- the film can be compact, porous or grid-like.
- the film is preferably peelable, separable, severable, pierceable, by suction, particularly preferably only partially, detachable and / or severable and / or soluble in saliva. To facilitate the separation and / or severing of the
- the foil closure can have lines of weakness, preferably predetermined separation points or predetermined breaking points, which preferably run radially outward from the center of the closure and divide the closure into segments of preferably the same size.
- This closure device preferably consists of materials from which the above carrier can be made.
- the straw opening can additionally be provided with a cap.
- the second drinking straw opening can also be provided with the above-mentioned film and / or cap.
- Another object of the invention also relates to a kit from the dosage form according to the invention and a physiologically harmless, optionally also active ingredient - nutrient and / or vitamin-containing transport liquid.
- An aqueous liquid is preferably used as the transport liquid, water, lemonade, fruit juice without pulp, tea or coffee being particularly preferred and should not contain any disruptive solids, such as pulp parts.
- FIG. 1 shows a partial view of a dosage form according to the invention
- Figure 2 shows an enlarged partial view of an inventive
- FIG. 1 shows a partial view of a drinking straw 1, which consists of straight legs 8, 12 connected to one another via the accordion-like means for curvature 15.
- the drinking straw 1 has the openings 6, 9, wherein the opening 6 is to be guided into the patient's mouth and the opening 9 is immersed in the transport liquid (not shown).
- a movable locking device 3 is arranged in the drinking straw 1 above the means for curving 15 the drinking straw 1.
- a multiparticulate active substance formulation 7 is arranged in the suction direction 5 behind the blocking device 3.
- a membrane-like closure device 4 made of a material that is soluble in the transport liquid and physiologically harmless is arranged in the drinking straw.
- the movement of the blocking device 3 in the drinking straw 1 is only possible in the suction direction 5 and between the means for curvature 15 and stop 10.
- the movable locking device is moved together with the formulation 7 toward the opening 6 when the transport liquid is sucked in through the drinking straw 1.
- the wording 7 can be passed through to the opening 6 essentially unhindered with the at least partially dissolved closure device 4.
- the locking device 3 is held in this position by the surface design of its sliding surface (not shown) and is prevented from moving back.
- the locking device 3 can also be seen from the outside through the viewing window 14 when the formulation has been removed. The person skilled in the art understands that the complete ingestion of the formulation can be determined when the locking device 3 abuts the upper stop 10.
- FIG. 2 shows an enlarged illustration of a part of the leg 8 with the opening 6 after the formulation has been sucked in.
- the opening 6 is closed by a removable cap 13.
- the leg 8 has below the stop 10, which extends around the entire inner circumference of the leg 8, a transparent viewing window 14, which extends over a partial circumference and a partial length of the leg 8 and allows a visual check of the removal of the formulation.
- the locking device 3, which can be moved within the drinking straw 1, has on its sliding surface 2 two opposite rows of saw teeth, which are only bevelled against the suction direction 5.
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10308175 | 2003-02-25 | ||
DE10308175A DE10308175A1 (de) | 2003-02-25 | 2003-02-25 | Darreichungsform und Kit zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
PCT/EP2004/001395 WO2004075876A1 (de) | 2003-02-25 | 2004-02-13 | Darreichungsform und kit zur oralen verabreichung von wirkstoffen, vitaminen und/oder nährstoffen |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1601342A1 true EP1601342A1 (de) | 2005-12-07 |
Family
ID=32797747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04710815A Withdrawn EP1601342A1 (de) | 2003-02-25 | 2004-02-13 | Darreichungsform und kit zur oralen verabreichung von wirkstoffen, vitaminen und/oder n ährstoffen |
Country Status (4)
Country | Link |
---|---|
US (1) | US20060043207A1 (de) |
EP (1) | EP1601342A1 (de) |
DE (1) | DE10308175A1 (de) |
WO (1) | WO2004075876A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005016169A1 (de) * | 2005-04-07 | 2006-10-12 | Grünenthal GmbH | Verfahren und Vorrichtung zum Aussortieren von Kappen |
FR2920308B1 (fr) * | 2007-09-05 | 2011-02-25 | Unither Dev | Forme pharmaceutique pour l'administration par voie orale de principes actifs. |
FR3022756B1 (fr) * | 2014-06-30 | 2017-09-01 | Unither Pharmaceuticals | Dispositif de dispensation d'un produit soluble avec une paille, notamment pour enfant et/ou personnes agees, cartouche adaptee |
EP3167772A1 (de) * | 2015-11-10 | 2017-05-17 | Unither Pharmaceuticals | Vorrichtung zur verabreichung eines löslichen produkts mit einem trinkhalm, insbesondere für kinder und/oder ältere menschen, und entsprechende einsatzpatrone |
EP3530256A1 (de) * | 2018-02-21 | 2019-08-28 | DS-Technology GmbH | Trinkhalm zur verabreichung eines wirkstoffs |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981468A (en) * | 1989-02-17 | 1991-01-01 | Eli Lilly And Company | Delivery device for orally administered therapeutic agents |
US5780058A (en) * | 1995-07-21 | 1998-07-14 | Alza Corporation | Oral delivery of discrete units |
US5718681A (en) * | 1996-01-11 | 1998-02-17 | Christopher E. Manning | Medication delivery straw |
ES2162262T3 (es) * | 1996-10-18 | 2001-12-16 | Alza Corp | Dispositivo para la administracion de agentes activos. |
CA2289668C (en) * | 1997-05-16 | 2003-12-23 | Alza Corporation | Flow controller configurations for an active agent delivery device |
US6217545B1 (en) * | 1999-02-08 | 2001-04-17 | Porex Technologies Corp. | Filter with varying density which is responsive to fluid flow |
JP2004512907A (ja) * | 2000-11-03 | 2004-04-30 | リカバリー ファーマシューティカルズ インコーポレーティッド | 禁煙用の装置および方法 |
-
2003
- 2003-02-25 DE DE10308175A patent/DE10308175A1/de not_active Withdrawn
-
2004
- 2004-02-13 WO PCT/EP2004/001395 patent/WO2004075876A1/de active Application Filing
- 2004-02-13 EP EP04710815A patent/EP1601342A1/de not_active Withdrawn
-
2005
- 2005-08-24 US US11/209,716 patent/US20060043207A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO2004075876A1 * |
Also Published As
Publication number | Publication date |
---|---|
DE10308175A1 (de) | 2004-09-02 |
US20060043207A1 (en) | 2006-03-02 |
WO2004075876A1 (de) | 2004-09-10 |
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Legal Events
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Inventor name: LAMM, NORBERT Inventor name: SEDAGHAT KERDAR, RASOUL |
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Effective date: 20100901 |