EP1599237A1 - Procede pour nettoyer un materiau d'implant osseux - Google Patents

Procede pour nettoyer un materiau d'implant osseux

Info

Publication number
EP1599237A1
EP1599237A1 EP04714234A EP04714234A EP1599237A1 EP 1599237 A1 EP1599237 A1 EP 1599237A1 EP 04714234 A EP04714234 A EP 04714234A EP 04714234 A EP04714234 A EP 04714234A EP 1599237 A1 EP1599237 A1 EP 1599237A1
Authority
EP
European Patent Office
Prior art keywords
nozzles
cleaning
bone
cleaning agent
bones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04714234A
Other languages
German (de)
English (en)
Inventor
Aleksandar Vujanic
Christoph Kment
Marek Soucek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ogms Osterreichise Gesellschaft fur Mikrosystemtechnik
Innovationsagentur GmbH
Original Assignee
Ogms Osterreichise Gesellschaft fur Mikrosystemtechnik
Innovationsagentur GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ogms Osterreichise Gesellschaft fur Mikrosystemtechnik, Innovationsagentur GmbH filed Critical Ogms Osterreichise Gesellschaft fur Mikrosystemtechnik
Publication of EP1599237A1 publication Critical patent/EP1599237A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to a method for producing a bone implant material, in which crushed bones are cleaned with a cleaning agent, and to an apparatus for carrying out this method.
  • Bones are implanted in a large number of people worldwide. Since body-related material brings with it a relatively high level of compatibility, bone fragments are also suitable as a carrier material for delivering medication directly to defined application parts. Tissue and bone banks have been set up to meet the need for implant material. In order to ensure a corresponding amount of implant material, it has already been proposed to clean cancellous bones. The cleaning methods that have become known in this connection are mostly time-consuming and technologically complex, with high criteria being set for cleaning with a view to the desired purpose of use in order to rule out an infection risk.
  • the cancellous structure of the bone substance is preferably used for such a cleaning, although cleaning is made more difficult by the large number of channels, cavities and blind holes. Appropriate surface cleaning does not lead to the desired result considering this structure.
  • granulation of bones into very small pieces with subsequent cleaning in a drum under the influence of a large number of different liquid chemicals has been proposed, for example.
  • a disadvantage of this method is that the granules obtained in this way are not easy to handle for larger implants. Bone implants are adapted to the respective intended use and it is therefore advantageous if the shape of the implant required in each case can be produced by cutting from a larger piece of bone. Larger pieces of bone are now again only to be cleaned with greater effort, the known cleaning methods mostly also being so time-consuming that it is hardly possible to provide the corresponding amount of material required in an economical manner.
  • the invention now aims to provide a method of the type mentioned, with which larger pieces of bone can be cleaned efficiently and in a short time from impurities and / or germs and overall an implant material can be provided in a form that is simpler Can be adapted to the respective application site and application.
  • the method according to the invention essentially consists in that the bones are comminuted by cutting them into disk-shaped parts and that the cleaning agent is sprayed onto the surface of the disk-shaped parts under pressure via one or more nozzles. Because the comminution is first carried out by cutting into disk-shaped parts, bone pieces that are easy to handle can be formed, which can be easily adapted to the respective implant site by further shaping.
  • the shape of the disk offers reproducible geometric requirements for the handling and use of cleaning agents, whereby, according to the invention, the cleaning agent is sprayed onto the surface under pressure via one or more nozzles, and a corresponding penetration into the channels, cavities or blind holes cancellous structures can be guaranteed.
  • the cleaning effect is preferably further improved by spraying the bones simultaneously from two or more directions.
  • the method according to the invention in which cleaning agents are sprayed on under pressure, is also suitable for relatively large bone parts, whereby, as is preferred, it can be carried out in such a way that the comminution to a disk thickness of less than 10 mm, preferably 5 mm to 7 mm. Such discs can subsequently be brought to the desired dimensions or the desired shape for an implantation in a particularly simple manner.
  • Intensive cleaning, even of relatively thick panes, can be achieved according to the invention in that the cleaning agent is expelled under a pressure of 1 bar to 10 bar, preferably 2 bar to 3 bar, and as already mentioned at the beginning, the procedure is advantageously such that the slices are cut from a part of a bone with a cancellous structure.
  • the spongy structure of the bone substance that is preferably used can be cleaned in a relatively short time to the highest level of purity and, if necessary, to ensure that it is sterile, the device to be used for the method according to the invention being relatively simple and requiring only minor investments.
  • the cleaning agent is advantageously expelled via a plurality of nozzles with a different axis of their jet, as a result of which the complex surface structure of cancellous bone substances can be taken into account.
  • nozzle heads such a plurality of differently oriented nozzles can be implemented in a simple manner, the procedure advantageously being that diethyl ether and / or alcohol is used as the cleaning agent for spray cleaning.
  • diethyl ether under a pressure of about 2 to 3 bar leads to "micro-explosions" and evaporation upon impact of the cleaning agent, with maximum protection of the surface structure due to the formation of turbulence in the micro-cavities mechanical and chemical cleaning can be done in a very short time.
  • the required cleaning time can be reduced even further by pivoting the bone disks and / or the nozzles during the spraying process.
  • the device according to the invention for carrying out the method is essentially characterized by a pump and / or a pressure tank for conveying cleaning agent to a nozzle head and a plurality of nozzles arranged in the nozzle head and a device for holding disks.
  • a corresponding nozzle head with a plurality of nozzles arranged in the nozzle head requires no complex construction, and the design can be freely selected within wide limits.
  • the design is advantageously such that the nozzles in the nozzle head are at least partially oriented in different directions from one another, a particularly preferred design being achieved if the nozzles are designed with an adjustable spray angle and / or adjustable spray direction.
  • FIG. 1 shows an embodiment of the cleaning device according to the invention
  • FIG. 2 shows a detailed view of the spray device.
  • Fig.l a prepared on slices of bone 1 is shown, which by simultaneous spraying with cleaning liquid under Pressure is cleaned.
  • the spraying takes place through several nozzles or nozzle blocks 2, which are designed to be movable in their orientation to the bone surface.
  • the jets of the cleaning liquid emerging from the nozzles or nozzle blocks 2 are denoted by 3.
  • F ⁇ g.2 it can be seen that the individual nozzles or nozzle blocks 2 can be designed to be pivotable according to the double arrow 4.
  • the movement of the nozzles or nozzle blocks can also take place linearly parallel to the bone disk surface according to the double arrows 5.
  • the same effect is naturally also achieved if the bone disk 1 is moved in an oscillating manner relative to the nozzles or nozzle blocks 2.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un procédé pour réaliser un matériau d'implant osseux, selon lequel les os fractionnés sont nettoyés au moyen d'un produit de nettoyage. Les os sont fractionnés par découpage en pièces en forme de disques et le produit de nettoyage est pulvérisé sous pression par une ou plusieurs buses sur la surface de ces pièces en forme de disques.
EP04714234A 2003-02-25 2004-02-25 Procede pour nettoyer un materiau d'implant osseux Withdrawn EP1599237A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0027703A AT413075B (de) 2003-02-25 2003-02-25 Verfahren zur herstellung eines knochenimplantatmaterials sowie vorrichtung zur durchführung dieses verfahrens
AT2772003 2003-02-25
PCT/AT2004/000056 WO2004075935A1 (fr) 2003-02-25 2004-02-25 Procede pour nettoyer un materiau d'implant osseux

Publications (1)

Publication Number Publication Date
EP1599237A1 true EP1599237A1 (fr) 2005-11-30

Family

ID=32913499

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04714234A Withdrawn EP1599237A1 (fr) 2003-02-25 2004-02-25 Procede pour nettoyer un materiau d'implant osseux

Country Status (3)

Country Link
EP (1) EP1599237A1 (fr)
AT (1) AT413075B (fr)
WO (1) WO2004075935A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT9318U1 (de) * 2006-05-15 2007-08-15 Ima Integrated Microsystems Au Vorrichtung zur reinigung von knochen oder knochenstücken
EP2303155A4 (fr) * 2008-06-23 2014-08-27 Allosource Chambre aseptique de nettoyage à l eau sous haute pression

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3841909A (en) * 1972-08-04 1974-10-15 Nitta Gelatin Kk Method and apparatus for removing grease from animal bones
DE2854490C2 (de) * 1978-12-16 1981-04-09 B. Braun Melsungen Ag, 3508 Melsungen Knochenersatzmaterial mit verbesserter biologischer Stabilität auf Basis von Kollagen
US4678470A (en) * 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
DE4339111A1 (de) * 1992-11-16 1994-05-19 Winterhalter Gastronom Gmbh Geschirrspülmaschine
US5554111A (en) * 1995-03-16 1996-09-10 Mayo Foundation For Medical Education & Research Bone cleaning and drying system
US5977432A (en) * 1997-06-09 1999-11-02 Life Net Research Foundation Process for cleaning bone grafts using centrifugal force and bone grafts produced thereby
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
DE19849984A1 (de) * 1998-10-29 2000-05-04 Tutogen Medical Inc Verfahren zur Präparation von Knochenmaterial
FR2798294B1 (fr) * 1999-09-10 2001-10-12 Ost Dev Procede de fabrication d'un materiau de prothese osseuse par traitement d'un tissu osseux naturel
US6627230B2 (en) * 2000-12-22 2003-09-30 Centerpulse Biologics Inc. Method of preparing a bone product by removing cancellous bone matrix

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2004075935A1 *

Also Published As

Publication number Publication date
WO2004075935A1 (fr) 2004-09-10
ATA2772003A (de) 2005-04-15
AT413075B (de) 2005-11-15

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