Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
  • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
  • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
  • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
  • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
  • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0001—Details of inhalators; Constructional features thereof
  • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
  • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
  • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
  • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
  • A61M15/0043—Non-destructive separation of the package, e.g. peeling
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
  • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
  • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
  • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
  • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
  • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
  • A61M15/006—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being discarded out of the inhaler's housing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0086—Inhalation chambers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0091—Inhalators mechanically breath-triggered
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0091—Inhalators mechanically breath-triggered
  • A61M15/0096—Hindering inhalation before activation of the dispenser
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2202/00—Special media to be introduced, removed or treated
  • A61M2202/06—Solids
  • A61M2202/064—Powder
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2206/00—Characteristics of a physical parameter; associated device therefor
  • A61M2206/10—Flow characteristics
  • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

• the present invention relates to a blister strip and a dry powder inhaler comprising such a strip.
• Inhalers are used to deliver pharmaceutical compounds to the lungs of a patient.
• an inhaler typically contains or provides a mixture of pharmaceutical compound particles and air or propellant.
• the mixture is delivered by inhalation of the patient at a mouthpiece placed on the inhaler with air or a propellant transporting the particles of pharmaceutical compound in the lungs of the patients.
• dry powder inhalers the particles of pharmaceutical compound, in the form of a fine dry powder, are entrained in an air flow and inhaled by the patient. Dry powder inhalers are often used to treat asthma. However, pharmaceutical compounds delivered via a dry powder inhaler can also be used to treat many cases, including cases not correlated to the lungs, via systemic absorption of the pharmaceutical compound into the bloodstream, through the lungs.
• a dry powder inhaler capable of delivering a large number of doses, such as 60, 90, or even 120 doses, before the inhaler needs to be recharged or replaced, would be advantageous.
• Some proposed dry powder inhalers achieve the goal of providing a large number of doses by individually measuring one dose at a time from a bulk powder storage compartment in the inhaler.
• it is difficult or even impossible to seal the water vapor of the bulk powder As a result, agglutination or powder aggregation or particle size growth may result, affecting the how much the powder distributed in the air. This tends to decrease the dose actually planned for the patient and / or lead to inconsistent doses.
• inhalers For example, it may be difficult to avoid double dosing with these types of inhalers, that is, opening two or more of the bags or containers on the dosing strip before inhalation, resulting in patient to inhale a larger than expected dose.
• known metered-dose inhalers release each dose from the strip via mechanical actuation by the patient, a dose can be released or opened from the strip and exposed to water vapor in the environment unless the dose is quickly inhaled.
• some known metered dose band inhalers have relatively complex mechanical configurations, with consequent complexity and manufacturing cost.
• a strip of blisters or metering intended for use in an inhaler comprises blisters or containers formed in a layer in the form of a strip.
• a covering layer is attached to the strip-shaped layer sealing a dose of a pharmaceutical compound of dry powder inside each of the blisters.
• a tear tape is attached to the cover layer on each of the blisters, preferably with locally applied adhesive.
• the covering layer is advantageously permanently fixed to the layer in the form of a strip.
• the strip is separable into a first section of tape comprising the strip-shaped layer and the areas of the covering layer surrounding the blisters, and a second section of tape comprising the tear tape and discs spaced from the layer. cover attached to the tear tape.
• the blisters advantageously contain a dry powder or a liquid.
• the blister strip is used in a dry powder inhaler having a powder dispersion motor comprising balls displaceable within a dispersion chamber.
• a blister opening system inside the inhaler sequentially opens vesicles on the strip, releasing the powder content of each blister in an air flow path leading to the dispersion chamber .
• the blister opening system is actuated by inhalation.
• the blister opening system automatically opens a blister. Additional blisters cannot be opened without resetting the inhaler and inhaling again at the mouthpiece. As a result, the possibility of inadvertently dispensing multiple doses is reduced (during a single inhalation).
• the blister opening system comprises first and second rotary elements.
• a spring biases the first rotary member to rotate in a first direction.
• An inhalation trigger holds the first element against rotation until the trigger is released, inhaling through a mouthpiece of the inhaler. Solicitation of the first rotary member is preferably accomplished by tensioning a spring by pivoting a dust cap at the mouthpiece.
• the blister opening system exerts a force only on the tape to be torn or pulled from the strip. This avoids potential damage to the other layers or tapes of the strip which in reality form the seal around the dose.
• the layers or ribbons which seal the dose are devoid of holes or openings used by the blister opening system to advance the strip. This is intended for a compact band configuration.
• the invention also resides in the subsystems, the components, and the steps as described below.
• Figure 1 is a perspective view from above and from the front of the present inhaler, with the dust cap in the closed position.
• FIG. 2 is a perspective view from below and from the front of the inhaler shown in FIG. 1.
• Figure 3 is a perspective view from above and from the front of the inhaler of Figure 1 with the dust cap in the open position.
• FIG. 4 is a perspective view from above of the inhaler of Figure 3 with the upper housing removed for illustrative purposes.
• FIG. 5 is an exploded view of a fragment representing elements of the blister opening system of FIG. 4.
• Figure 6 is a perspective view from above of the blister opening system shown in Figure 5, in the initial or closed position.
• Figure 7 is a perspective view from above with the inhaler in the open / ready position.
• Figure 8 is a perspective view from above showing the inhaler during inhalation.
• FIG. 9 is a perspective view from above showing the replacement of the inhaler from the position of FIG. 8 to the initial position shown in FIG. 6.
• FIG. 10A is a perspective view from below of components of the blister opening system shown in FIG. 4.
• Figure 10B is a perspective view of the pawl shown in Figures 4 and 5.
• Figure 11 is an exploded perspective view of the blister strip shown in Figures 4 and 10A.
• Figure 12 is a sectional view taken along line 12-12 of Figure 11.
• FIG. 13 is a perspective view showing the strip of FIG. 12 after use and separated into a layer of torn tape / covering, and into a layer of tearing tape / covering disc.
• Figure 14 is a top view of an alternative embodiment.
• Figure 15 is an enlarged partial view of the embodiment shown in Figure 14.
• Figure 16 is an enlarged partial view of another alternative embodiment.
• an inhaler 20 has an inhaler housing 22 formed by an upper housing 24 and a lower housing 26.
• a dust cap 30 is pivotable from a closed position, as shown in Figure 1, to an open position, as shown in Figure 3. In the closed position, a hollow section 32 of the dust cap 30 supported by an upper arm 34 and a lower arm 36 covers the mouthpiece 28.
• the inhaler 20 includes an air flow path generally designated by the dotted lines with the reference numeral 50.
• the air flow path extends from entry 52 in a housing 22 beyond or through an opening / advancing subsystem of a metering system 58, in a dispersion chamber 40 and up to the mouthpiece 28.
• the dispersion chamber 40 has an annular open space in which one or more ball (s) moves (s) as described in international application PCT / US01 / 03248 (corresponding to US patent application No. 09 / 773,261) incorporated here as reference.
• a metering or blister strip or tape 150 is produced in the form of a coil 60 within the inhaler 20.
• a band retaining wall 64 surrounds the coil 60 except at the band opening / advancing system 58.
• the band opening / advancement system 58 includes an inhalation flap assembly 110 having an inhalation wall 112 and a bottom plate 114 connected together or in one piece with a rotation shaft 116 pivotally supported on the lower bottom housing 26.
• the band opening / advancement system 58 comprises a pawl 88 having a trigger arm 90 and a pawl head 92 fixed to a trigger plate 96. Latching arms of pawl or elastic 94 form a spiral going outward from the pawl head 92.
• a drive coil 76 has a notched gear 78 at its upper end. Band pins 80 extend radially outward from the cylindrical body of the drive coil 76 below the notched gear 78. Ratchet teeth 82 are provided on the inner top end of the coil d drive 76, in the perimeter of the notched gear 78.
• the drive coil 76 is positioned on and around the pawl 88, with the pawl arms 94 being able to engage in the pawl teeth 82 allowing the pawl 88 to drive the drive coil 76 in a forward direction (clockwise in Figure 4), and not in the reverse direction.
• the arm of the lower dust cap 36 is associated (glued, fixed by pins, welded by ultrasound, etc.) to a loading cam 102 having a central cam hub 106 and a cam recess 104.
• a spring 98 is attached in the cam hub 106 and to the pawl 88. As shown in FIG.
• a capstan 70 pivotally supported on a mounting shaft 74 extending upward from the lower housing 26 has a notched gear 72 at its upper end which engages with the notched gear 78 of the drive coil 76.
• the front end 155 of the tape reel 60 extends around the cylindrical body of the capstan 70, as it moves in the opening / advancing system of the tape 58.
• the 150 has a ribbon or strip-like layer 152 with recesses, containers or blisters 160 spaced linearly equally apart.
• the stripe layer 152 is preferably a sheet of metal, such as aluminum, with the blisters 160 formed in the stripe layer 152 using well known techniques.
• a measured volume of pharmaceutical compound powder 162 is placed in each blister 160.
• a tape or covering layer 154 preferably also a sheet of metal, such as aluminum, is preferably permanently attached to the layer in strip form 152 using well known techniques such as compression welding, adhesives, etc. Black for example, US patents
• a cut or tear tape or layer 158 is attached to each of the cover discs 168, preferably using locally applied adhesive 156.
• the tear tape 158 is advantageously Mylar.
• the tear tape includes pairs of drive holes between the blisters. Referring to Figure 12, the locally applied adhesive 156, if used, is placed on the cover discs 168. In the gap areas 164 between the adjacent blisters 160, the tear tape 158 is preferably hung from the above the covering layer 154, leaving a gap or space 166 between the tear tape 158 and the covering layer 154 between the blisters 160.
• the metering tape 150 is fabricated such that when the tear tape 158 is removed from the tape as tapes, the cover discs 168 separate from the cover tape 154 to open the blisters 160.
• the dosing strip 150 is separated into a used cover tape 170 comprising the tear tape 158, the adhesive 156 (if used) and the covering discs 168, and a tape in the form of strips 172 comprising the layer or the ribbon in the form of strips 152 and the areas of covering layer 154 surrounding the blisters 160.
• the inhaler 20 is removed from its packaging or packaging
• the dust cap 30 is in the closed position as shown in Figures 1 and 2. While preferably holding the inhaler in an upright position with the upper housing 24 facing upward, the user removes the dust cap 30 of the mouthpiece 28 in the open position as shown in FIG. 3. This movement advances the strip 150 and opens a bhster or a container
• the inhaler 20 is provided with the front end 155 of the reel 60 of the strip 150 engaged between the capstan 70 and the drive reel 76. Specifically, at least one and preferably two pairs of strip pins extend through the drive holes 165 in the tear tape positioned between the blisters 160. No drive holes are provided in the stripe layers and in the cover layers. As shown in Figure 6, in the closed position, the dust cap 30 covers the mouthpiece 28. This helps keep the mouthpiece 28 clean between each use. Going to Figure 7, the user pivots the dust cap 30 from the closed position shown in Figure 6 to the open position shown in Figure 7. The loading cam 102 moves with the dust cap 30, since 'it is attached to the lower arm 36 of the dust cap 30.
• This movement (approximately 130 ° in the embodiment shown) energizes the spring 98 which in turn biases the pawl 88 in the forward direction (direction of clockwise in Figure 7).
• the inhaler can alternatively be configured such that a spring is energized by moving the dust cap from an open position to a closed position.
• the recess 104 in the cam moves in alignment with or adjacent to the bottom plate 114 of the inhalation flap assembly 110.
• the outwardly deflecting pawl arms 94 engage with the pawl teeth 82 on the inner surface of the drive coil 76.
• the pawl 88 and the drive coil 76 cannot rotate, because the trigger arm 90 of the pawl 88 is held against the assembly inhalation shutter 110.
• the end of the trigger arm 90 bears against the pivot point 116 and against the inhalation wall 112. This prevents the pawl 88 and the drive coil 76 from any rotation . Consequently, with reference to FIGS. 6 and 7, the opening movement of the dust cap 30 only energizes the spring 98 without displacing (significantly) the other components of the belt opening / advancing system 58.
• the user places the mouthpiece 28 in the mouth and inhales.
• Inhalation causes air to flow through the air flow path 50. Specifically, air flows into the housing 22 through the inlet 52 in the lower housing 26. The air then pushes against the inhalation wall 112 of the inhalation shutter assembly 110, flows into the inlet duct of the chamber 46, through the chamber 42 and exits at the nozzle. buccal 28. The air pushing against the inhalation wall 112 causes the inhalation flap assembly 110 to pivot, counter-clockwise, as shown in FIG. 8. This moves the trigger arm 90 of the pawl 88 of the pivot point 116.
• the drive coil 76 also moves, driven by the pawl 88.
• the notched gear 78 on the drive coil 76 also drives the notched gear 72 on the capstan 70, causing the capstan 70 to turn in the direction opposite with an equal level of rotation.
• the tape pins 80 extending toward the drive holes 165 in the tear tape 158 pulls the metering tape 150 forward. Referring momentarily to FIG. 10 A, the movement of the drive reel removes the tear tape 158 from the tape in the form of strips 152.
• the capstan 70 has recesses 171 around its outer perimeter sized to be engaged around blisters 160.
• Figure 10A is a bottom view in which the directions are reversed.
• the flow of air passing through or beyond the open position of the blisters 174 leads the powder of pharmaceutical compounds 162 to be released from the bhster 160.
• the powder and the air flow through the conduit of inlet 46 into chamber 42.
• the air / powder mixture enters the circular or toroidal chamber either tangentially or on a cord.
• the powder / air mixture and the balls 44 circulate rapidly inside the chamber 42. This movement disperses or sprays the powder 162 and also helps the particles of active pharmaceutical compounds to separate from the excipient or the carrier particles in the powder 162, if used.
• FIGS. 4 and 10A when the strip 150 moves through the strip opening / advancement system 58, the strip 150 separates into covering tapes used 170 and into tapes in the form of used strips 172.
• the cover tape used 170 which includes the tear tape 158, the adhesive 156 (if used) and the discs 168 separate from the cover tape 154, is pulled around the spool 76, and is pushed into space of covering material 66 in the housing 22.
• the guide 84 shown in FIG. 6, helps to direct the ribbon 170 into the space 66.
• the sheet ribbon used 172 which includes the ribbon in the form of strips 152 and the cover strip 154 permanently attached to the strip in the form of a strip
• the capstan 70 preferably does not include pins band 80, as on the driving reel 76.
• the capstan 70 acts rather as a point of rotation for the ribbon in the form of used strips 170.
• the pulling movement of the driving reel 76 acting on the incoming strip 150 in the opening / advancing system of the strip 58 pushes the ribbon in the form of a strip used 172 in the space 68.
• the inhaler 20 is returned to the initial position, preparing to deliver a subsequent dose by pivoting the dust cap 30 to its original closed position on the mouthpiece 28, as shown in FIG. 9.
• This movement turns the pawl 88 in a second direction, opposite to the first direction (the second direction being in the anticlockwise direction in FIG. 9).
• the connection between the pawl 88 and the loading cam 102 allows the movement of the dust cap 30 to turn the pawl 88 only in the second direction, that is to say anticlockwise.
• Figure 9 The opening movement of the dust cap 30 does not rotate the cam 28. When the dust cap is closed, the pawl 88 rotates anti-clockwise.
• the drive coil 76 does not move, since the arms of pawl 94 on the pawl 88 flex inward and slide over the pawl teeth 82 on the drive coil 76. Consequently, during the step of returning to the initial position shown in FIG. 4, when the dust cap 30 is returned to its closed position, the drive coil 76, the capstan 70, and the strip 150 do not move.
• the counterclockwise movement of the pawl 88 with the closing of the dust cap 30 generates a return of the trigger arm 90 of the pawl 88 to the position shown in FIG. 6 and simultaneously puts the assembly back in the initial position of the inhalation flap 110 to the position shown in FIG. 6.
• the cam recess 104 moves away from the bottom plate 114 of the inhalation flap assembly 110, preventing movement of the assembly of inhalation shutter.
• the inhaler 20 is then ready to repeat the steps described above to deliver another dose of a powder of pharmaceutical compounds contained in the next blister 160 approaching the opening / advancing system of the band 58.
• the dosing strip 150 can contain up to 120 doses or more. After all doses have been used, the inhaler 20 can be discarded. Alternatively, in a reusable configuration, the housing 22 can be opened, the used tapes 170 and 172 removed and discarded, and a replacement tape 150 in the form of a spool 60 installed.
• the tape pins 80 on the drive coil 76 pull on the tear tape 158 only after the tear tape 158 is separated from the tape in the form of tape 152. This allows apply high tape displacement forces to tape 150 without damaging it. As relatively high forces can be used to move the strip 150 and to open the blisters as shown in Figure 13, movement of the strip and opening of the blister can be accomplished quickly, so that the release of the powder takes place at or near the inhalation spike, when there is a rapid air flow through the air flow path 50. Therefore, the inhaler 20 can be actuated by inhalation.
• another advantage is the relatively simple shape of the inhaler 20. No clutch or other complicated mechanical component or mechanism is necessary.
• the strip 150 has regularly spaced blisters 160. As the strip tapes used 170 and 172 are not wound on the drive coils, there is no need to compensate for the clutch or the movement of the drive mechanism. The movement of the opening / advancing system of the strip 58 is rather identical for each blister.
• the tear tape 158 is a separate layer or tape (preferably polyester) not involved in sealing the powder, it can be adapted to transfer high forces for the movement of the tape 150. This is contrary to Existing band inhalers which move the band by playing on the sheet metal layers, which are not able to handle high forces as well.
• the drive coil 76 apphque a force to move the band 150 not only of the pinch or the open position of the bhster 174, but also on a sector of the drive coil 76 up to or above 90 °. This helps to apply forces to advance and open the strip 150 quickly and evenly.
• the user only needs to move the dust cap between the open and closed positions. No other user or patient manipulation or movement is required. As all other operations in the inhaler 20 are automatic, the human factors for using the inhaler 20 are greatly simplified. Therefore, training the patient, and maintaining a correct dosing regimen is also simplified.
• the blister opening system 58 can of course also be used in other types of inhalers, having various air flow paths, chambers and different mouthpieces.
• the dispersion chamber 40 is generally preferred, it is not an essential element.
• the blister opening system 58 can be energized by a separate lever or other element independent of the dust cap.
• FIGS. 14 and 15 represent a second embodiment 200 comprising an alternative blister / strip opening system 201, similar to the system 58 described above.
• the bhster opening system: forward of the alternative band 201 comprises a capstan 202 having recesses 71 for receiving the blisters, similar to the capstan 70.
• the system 201 also comprises a drive coil 204 similar to the drive coil 76.
• the strip 150 is wrapped around the capstan 202 with the blisters facing inwards, such that they are received or engaged with the recesses 71.
• the strip 150 separates into a ribbon of used vesicle 172, which is pushed into space 68 and into a covering tape 170.
• the covering tape envelops a pressure roller 206, the drive coil 204, and a drive pressure roller 208.
• the pressure roller 206 reverses the direction of the path of the strip and helps to keep the strip in engagement with the capstan 202.
• the drive pressure roller 208 helps to keep the strip 150 wound around the drive coil 204.
• the pressure rollers 206 and 208 are devoid of tension rollers rotatable.
• the opening of the air flow path in the chamber inlet duct is located between the capstan 202 and the pressure roller 206.
• the operation of the vesicle opening / advancement system of the band 201 is similar to the system 58, with the following differences.
• the capstan 202 is driven or turned by the advancing strip.
• the force of advancement of the strip and opening of the blister is preferably applied to the strip, in this embodiment, by the drive reel 204 acting on the tear tape 158. As little or no force is applied to the blisters, and because the capstan 202 and the drive coil 204 do not touch each other, potential damage or alteration of the blisters is avoided.
• the drive holes 165 in the strip 150 need only be in the tear tape, not in the strip layer 152 or the cover layer 154. This helps maintain the integrity of the seal provided in each blister.
• the water vapor migrates in the bhsters after a certain time through the layer of adhesive or through the microscopic interstices between the layers 152 and 154 (rather than through the layers themselves). Consequently, the wider the continuous layer of glue, the better the sealing or barrier properties of the finished strip.
• the arrangement of the drive holes 165 in the layers 152 and 154 would require that the strip 150 be wider to obtain a given quality or level of tightness. By avoiding the drive holes 165 in the layers 152 and 154, the band 150 and the inhaler can be more compact.
• gears 72 and 78 are provided on the drive coil 204 and the capstan 202, and are in engagement with each other.
• the capstan 202 and the drive coil 204 can still be spaced far enough apart to avoid damage or alteration of the blisters when the blisters approach the open position.

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• 2003
  • 2003-01-22 US US10/350,154 patent/US7171965B2/en not_active Expired - Fee Related
• 2004
  • 2004-01-20 JP JP2005518710A patent/JP4464923B2/ja not_active Expired - Fee Related
  • 2004-01-20 WO PCT/FR2004/000114 patent/WO2004067069A2/fr not_active Ceased
  • 2004-01-20 CN CNB2004800051277A patent/CN100525852C/zh not_active Expired - Fee Related
  • 2004-01-20 EP EP04703421A patent/EP1587565A2/de not_active Withdrawn
  • 2004-11-10 US US10/984,870 patent/US7322354B2/en not_active Expired - Lifetime
  • 2004-11-10 US US10/984,869 patent/US7322353B2/en not_active Expired - Lifetime
  • 2004-11-10 US US10/984,856 patent/US7434579B2/en not_active Expired - Lifetime
• 2009
  • 2009-02-12 JP JP2009030019A patent/JP4960978B2/ja not_active Expired - Fee Related

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