EP1531677A4 - Three dimensional vaginal tissue model containing immune cells - Google Patents

Three dimensional vaginal tissue model containing immune cells

Info

Publication number
EP1531677A4
EP1531677A4 EP03734125A EP03734125A EP1531677A4 EP 1531677 A4 EP1531677 A4 EP 1531677A4 EP 03734125 A EP03734125 A EP 03734125A EP 03734125 A EP03734125 A EP 03734125A EP 1531677 A4 EP1531677 A4 EP 1531677A4
Authority
EP
European Patent Office
Prior art keywords
immunocells
vaginal
dimensional
weave
model
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03734125A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1531677A2 (en
Inventor
Mitchell Klausner
Seyoum Ayehunie
Joseph Kubilus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MatTek Corp
Original Assignee
MatTek Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MatTek Corp filed Critical MatTek Corp
Publication of EP1531677A2 publication Critical patent/EP1531677A2/en
Publication of EP1531677A4 publication Critical patent/EP1531677A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1114—T cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121—Dendritic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/24—Genital tract cells, non-germinal cells from gonads
    • C12N2502/243—Cells of the female genital tract, non-germinal ovarian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP03734125A 2002-06-07 2003-05-21 Three dimensional vaginal tissue model containing immune cells Withdrawn EP1531677A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/165,267 US6943021B2 (en) 2002-06-07 2002-06-07 Three dimensional vaginal tissue model containing immune cells
US165267 2002-06-07
PCT/US2003/016167 WO2003104393A2 (en) 2002-06-07 2003-05-21 Three dimensional vaginal tissue model containing immune cells

Publications (2)

Publication Number Publication Date
EP1531677A2 EP1531677A2 (en) 2005-05-25
EP1531677A4 true EP1531677A4 (en) 2006-11-29

Family

ID=29710402

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03734125A Withdrawn EP1531677A4 (en) 2002-06-07 2003-05-21 Three dimensional vaginal tissue model containing immune cells

Country Status (6)

Country Link
US (2) US6943021B2 (https=)
EP (1) EP1531677A4 (https=)
JP (1) JP4531558B2 (https=)
AU (1) AU2003239561A1 (https=)
CA (1) CA2488575A1 (https=)
WO (1) WO2003104393A2 (https=)

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WO2005014149A1 (ja) * 2003-08-07 2005-02-17 Asahi Kasei Kabushiki Kaisha 複合多孔膜とその製造方法
EP1937798A4 (en) * 2005-04-15 2009-05-13 Univ Columbia CHEMICALLY DEFINED CULTURAL MEDIA FOR THE EXPANSION AND DIFFERENTIATION OF EPIDERMIC CELLS AND USES THEREOF FOR THE IN VITRO FARMING OF HAIRFOLLICLES
JP4792566B2 (ja) * 2005-06-01 2011-10-12 財団法人ヒューマンサイエンス振興財団 樹状細胞を含む三次元培養ヒト皮膚モデル
EP1762609B1 (en) * 2005-09-13 2012-04-04 Takara Bio Inc. Serum-free medium for the production of retroviral vectors
WO2007031273A2 (en) * 2005-09-16 2007-03-22 Universität Bern Artificial immune-reconstituted epidermis equivalents
EP2260097B1 (en) * 2008-03-12 2017-04-26 Sanofi Pasteur VaxDesign Corporation Disease model incorporation into an artificial immune system (ais)
JP2010046058A (ja) * 2008-07-24 2010-03-04 Two Cells Co Ltd 治療用培養細胞の製造方法
CN103797110B (zh) 2011-07-12 2017-08-25 食品安全测试系统公司 沙门氏菌和大肠杆菌的培养基和培养方法以及用于检测沙门氏菌和大肠杆菌的方法
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ITMI20120104A1 (it) * 2012-01-30 2013-07-31 Cutech S R L L'utilizzo di tessuto umano proveniente da piccole labbra dei genitali femminili
JP5977580B2 (ja) * 2012-05-24 2016-08-24 秀実 高橋 ランゲルハンス細胞の調製方法
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
EP3145489A1 (en) 2014-05-22 2017-03-29 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
GB2567269B (en) * 2015-10-22 2021-10-06 Univ Pennsylvania Systems and methods for producing micro-engineered models of the human cervix
CN105483085B (zh) * 2016-02-16 2019-02-26 广州赛莱拉干细胞科技股份有限公司 一种dc细胞培养方法及培养基
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10297085B2 (en) * 2016-09-28 2019-05-21 Intel Corporation Augmented reality creations with interactive behavior and modality assignments
US20180100142A1 (en) * 2016-10-06 2018-04-12 Mattek Corporation Methods and Kits for Production of Tissue Equivalents from Cryopreserved Cells
CN108342322A (zh) * 2018-02-24 2018-07-31 宁夏医科大学总医院 建立原代人子宫内膜上皮细胞气液相培养模型的方法
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN113293126B (zh) * 2021-04-01 2023-11-07 广东博溪生物科技有限公司 一种人阴道粘膜模型的体外构建方法
WO2023278286A1 (en) * 2021-06-28 2023-01-05 Mattek Corporation Intestinal and respiratory tissue models containing enterocytes, fibroblasts, immune cells, and endothelial cells
CN115181719B (zh) * 2022-07-13 2023-09-15 福建省海西细胞生物工程有限公司 一种用于培养组织工程表皮的无血清培养基
CN118853540B (zh) * 2024-09-27 2024-12-10 济南磐升生物技术有限公司 一种人阴道上皮模型的体外构建方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0789074A1 (fr) * 1996-01-23 1997-08-13 L'oreal Equivalent de peau comprenant des cellules de Langerhans

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US5863531A (en) 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5160490A (en) 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
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US5766944A (en) 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
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Title
AYEHUNIE S ET AL: "Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products", TOXICOLOGY IN VITRO 2006 UNITED KINGDOM, vol. 20, no. 5, 2006, pages 689 - 698, XP002401734, ISSN: 0887-2333 *
BERNARD F-X ET AL: "Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin", EXPERIMENTAL DERMATOLOGY, COPENHAGEN, DK, vol. 11, no. 1, February 2002 (2002-02-01), pages 59 - 74, XP002251235, ISSN: 0906-6705 *
COLLINS KELLY B ET AL: "Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract", NATURE MEDICINE, vol. 6, no. 4, April 2000 (2000-04-01), pages 475 - 479, XP002401732, ISSN: 1078-8956 *
DELVENNE P ET AL: "The organotypic culture of HPV-transformed keratinocytes: an effective in vitro model for the development of new immunotherapeutic approaches for mucosal (pre)neoplastic lesions", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 19, no. 17-19, 21 March 2001 (2001-03-21), pages 2557 - 2564, XP004231080, ISSN: 0264-410X *
DOUCET O ET AL: "Characterization of the Barrier function, hydration and pH of 3D-epithelial cultures cultivated from foreskin, corneal, buccal and vaginal cells", PERSPECTIVES IN PERCUTANEOUS PENETRATION, vol. 7A, 2000, pages 53, XP001247629 *
ECKERT R L ET AL: "Molecular biology of keratinocyte differentiation.", ENVIRONMENTAL HEALTH PERSPECTIVES. MAR 1989, vol. 80, March 1989 (1989-03-01), pages 109 - 116, XP002402480, ISSN: 0091-6765 *
KREBS FRED C ET AL: "Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: Comparative sensitivity of primary human vaginal keratinocytes", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 44, no. 7, July 2000 (2000-07-01), pages 1954 - 1960, XP002401733, ISSN: 0066-4804 *
SCHALLER MARTIN ET AL: "The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.", INFECTION AND IMMUNITY, vol. 71, no. 6, June 2003 (2003-06-01), pages 3227 - 3234, XP002402481, ISSN: 0019-9567 *
See also references of WO03104393A2 *

Also Published As

Publication number Publication date
JP2005530500A (ja) 2005-10-13
CA2488575A1 (en) 2003-12-18
WO2003104393A3 (en) 2004-08-05
US20030228686A1 (en) 2003-12-11
US6943021B2 (en) 2005-09-13
US20080003677A1 (en) 2008-01-03
AU2003239561A1 (en) 2003-12-22
WO2003104393A2 (en) 2003-12-18
JP4531558B2 (ja) 2010-08-25
AU2003239561A8 (en) 2003-12-22
EP1531677A2 (en) 2005-05-25

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