EP1473145B1 - Procédé pour le pressage d'essai de comprimés - Google Patents

Procédé pour le pressage d'essai de comprimés Download PDF

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Publication number
EP1473145B1
EP1473145B1 EP04008672.0A EP04008672A EP1473145B1 EP 1473145 B1 EP1473145 B1 EP 1473145B1 EP 04008672 A EP04008672 A EP 04008672A EP 1473145 B1 EP1473145 B1 EP 1473145B1
Authority
EP
European Patent Office
Prior art keywords
rotor
rams
filling
dies
die
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP04008672.0A
Other languages
German (de)
English (en)
Other versions
EP1473145A2 (fr
EP1473145A3 (fr
Inventor
Jürgen Hinzpeter
Ingo Schmidt
Ulrich Gathmann
Jörg Gaedecke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fette GmbH
Original Assignee
Fette GmbH
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Filing date
Publication date
Application filed by Fette GmbH filed Critical Fette GmbH
Publication of EP1473145A2 publication Critical patent/EP1473145A2/fr
Publication of EP1473145A3 publication Critical patent/EP1473145A3/fr
Application granted granted Critical
Publication of EP1473145B1 publication Critical patent/EP1473145B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements

Definitions

  • the invention relates to a method for the test-pressing of tablets according to claim 1.
  • Tablets are commonly made with rotary tablet presses or rotary tableting machines.
  • Such machines include a rotor having a die plate having a series of dies, upper and lower dies co-operating with the dies and at least one printing station in which the dies are pressed into the dies against the charged material in the die , This happens during the rotation of the rotor, which is driven by a suitable drive device.
  • the dies Before pressing, the dies must be filled with the material to be pressed (powder). This happens continuously when the rotor rotates in a so-called filling shoe or a filling arrangement, which is arranged stationary.
  • Pressing tests with a production rotary press naturally have the advantage that the data determined during compression tests can be transferred directly to the production. In addition, all settings of the rotary press can be taken from the press trial for production use.
  • the invention has for its object to provide a method for introspressung of tablets, which is on the one hand under production conditions feasible and on the other hand manages with minimal Preßmaterialaufwand.
  • a conventional tabletting machine is used, as it is usually used in production.
  • a rotary tabletting machine therefore, such a machine can be used according to the invention for experimental purposes.
  • the filling process normally consists of the filling process and the dosing process.
  • the lower punches which are located inside the die are moved downwards by a certain amount in order to release a volume of the die for the filling of material.
  • the rotor is stopped in a position in which a lower punch is in the filling position, ie, the lower punch specifies exactly the filling volume in the die. It is not problematic to approach this position by means of the drive control, since it has long been known to enable the rotation of the rotor by means of suitable angle detection arrangements monitor and control. Such monitoring is required when press characteristics are to be assigned to the individual pairs of punches.
  • the filling of the single die can z. B. by hand or with the help of a special suitable filling device.
  • the usual Be Shellan Aunt is removed or driven to the side so far that the filling of the single die is possible. It is understood that even a limited number of dies can be filled with molding material. For this purpose, it is then necessary that the rotor moves step by step the associated matrices in the filling position.
  • the rotor After filling the die, the rotor is rotated and accelerated so far that it has reached the desired production speed or rotational speed upon reaching the printing station. If the printing station has a pre-printing station, then the rotor must already have the production speed in the pre-printing station. Frequently, in larger rotary tableting machines, three printing stations are used with three filling arrangements for pressing three tablets in parallel at the same time. In this case, the rotor is only a relatively small distance to reach the production speed available. With current drives, this can be achieved.
  • the rotor After a single revolution, the rotor is stopped in the filling position, and it is now possible, the signals or waveforms of the individual measuring points, for. As main and form, ejection force, stamp binding, etc., which have recorded during the rotation measured values to be evaluated in a computer or to be displayed by this.
  • All process-relevant settings can be set and tried in the compression test, such as speed, compressive force, tablet thickness, tablet hardness, tablet weight, etc.
  • To test the compressibility of new tablet forms only one pair of punches must be made. It is also possible to test a number of different punch shapes that are used in pairs in the rotor. With a single revolution of the rotor thus a plurality of different punch shapes can be examined.
  • a rotor 10 of a rotary tableting machine having a die plate 12 with a series of dies 14 arranged on a circle about the axis of the rotor 10 with die bores 16 for receiving material to be pressed.
  • Each die 14 or die bore 16 is associated with an upper punch and lower punch, which in Fig. 1 are not shown.
  • a pre-printing station 18 and a main printing station 20 are stationary. They have paired pressure rollers, of which 22 and 24 respectively a lower pressure roller is shown. The pressure rollers cooperate with the facing ends of the punches to press them into the die bores 16 and to press the material therein.
  • a filling arrangement 26 is shown in the direction of rotation in front of the printing station 18. The details of the filling arrangement should not be discussed, since they are known. With the help of the filling arrangement, which has a certain volume and is filled continuously via a hopper, the matrices are filled, each run below the filling assembly 26. During this movement, the die holes are gradually filled with pressing material.
  • the finished in the main printing station 20 tablets are from ejected from the lower punches while the upper punches are above the dies.
  • a scraper (not shown) ensures that they are pushed to a tablet drain 28.
  • Fig. 2 two upper punches are shown at 30, while a number of sub-punches 32 are shown in phantom. It can be seen that the punches 30, 32 move from the printing station 18 to the right and occupy different positions in height relative to the die plate 12. This is achieved by a control curve 34 for the upper punch 30 and by a control cam 36 for the lower punch 32 for ejection. Following the main printing station 20, the filling takes place, wherein in Fig. 2 the filling assembly 26 after Fig. 1 not shown or is removed. The upper punches 30 have a raised position outside the die bore, with the top of the in Fig. 2 not shown Matrizenassociated is indicated by the dashed line 36a.
  • the oblong box 38 indicates the filling section and the box 40 indicates the metering section.
  • these are gradually driven by control cams, not shown, so that they release a portion of the die bore for filling with molding material.
  • the punches 32 are raised again slightly. In this raised position of the lower punches 32, the filling volume is defined in the die bore.
  • a small part of the previously filled press material is lifted out of the die bore, which can then be stripped off approximately by the filling assembly 26.
  • Following the upper punch 30 are lowered by the cam 42 and driven under the next printing station, which may be the pre-printing station 18 or another pre-printing station, if more than one pre and main printing station is provided.
  • the rotor 10 When a compression test is performed, the rotor 10 is brought into a position in which a lower punch 32 is in the filling position, as indicated by 40 in FIG Fig. 2 indicated. Now, with the rotor 10, the die bore 16 is filled with pressing material with the aid of a suitable filling device or by hand.
  • the control for the drive, not shown, of the rotor 10 is set via a computer so that the rotor is automatically rotated after the Stärt exactly one revolution, so that the working pair of punches is back in the filling position.
  • the acceleration of the rotor drive is adjusted so that the production speed is reached in the pre-printing station 18 to avoid slope angle.
  • the rotation data for the compression of the material are recorded by means of suitable measuring points not shown. These include the rotational speed of the rotor 10 and the pressing characteristics in the pre-and main pressure stations 18, 20, which are measured by means of suitable pressure or Kraftmeßaufillon.
  • the signals of the measuring points are recorded in the computer and brought to display and evaluation. It can be pressed in this way automatically several individual tablets in succession, wherein after each revolution process and tablet parameters can be adjusted automatically due to the measurement data or by predetermined changes in the adjustment parameters to determine optimal production conditions.
  • the data obtained in the compression test can be easily transferred to the tableting machine under production conditions.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Basic Packing Technique (AREA)

Claims (4)

  1. Procédé pour le pressage d'essai de comprimés avec une machine rotative à fabriquer des comprimés, avec un rotor (10) entraîné en rotation qui présente une série de poinçons supérieurs et inférieurs (30, 32), un disque de matrices (12) avec des matrices (14) avec lesquelles les poinçons interagissent, un système de cames de commande (34, 36) pour les poinçons et un dispositif de remplissage pour le remplissage continu des matrices pendant la rotation du rotor, en outre avec au moins un poste de pression au niveau duquel le matériau présent dans les matrices est pressé en un comprimé et un dispositif de mesure présentant plusieurs emplacements de mesure à partir duquel au moins la force de pression exercée par les poinçons et la vitesse de rotation du rotor sont mesurées, caractérisé par les étapes de procédé suivantes :
    une paire de poinçons sélectionnée pour un pressage individuel est conduite automatiquement à une position de remplissage,
    alors que le dispositif de remplissage est au moins partiellement éloigné et le rotor est immobile, une matrice ou un nombre limité de matrices (14) est rempli(e) de matériau,
    le rotor est ensuite mis en rotation et accéléré de sorte qu'il a dans le poste de pression la vitesse de production souhaitée,
    après une rotation, le rotor (10) est retenu dans la position de remplissage et, pendant la rotation du rotor, des signaux ou des courbes de signaux des emplacements de mesure sont enregistrés et fournis à un ordinateur pour affichage et analyse.
  2. Procédé selon la revendication 1, caractérisé en ce que seule une paire de poinçons ou un nombre limité de paires de poinçons est monté(e) dans le rotor.
  3. Procédé selon la revendication 1 ou 2, caractérisé en ce que les paires de poinçons affectées aux matrices à remplir ont une forme différente.
  4. Procédé selon une des revendications 1 à 3, caractérisé en ce que, après chaque rotation du rotor, les paramètres de comprimés et/ou de process sont adaptés automatiquement sur la base des données de mesure ou par des modifications prédéfinies des paramètres de réglage.
EP04008672.0A 2003-04-28 2004-04-10 Procédé pour le pressage d'essai de comprimés Expired - Lifetime EP1473145B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319024 2003-04-28
DE10319024A DE10319024B3 (de) 2003-04-28 2003-04-28 Verfahren zur Versuchspressung von Tabletten

Publications (3)

Publication Number Publication Date
EP1473145A2 EP1473145A2 (fr) 2004-11-03
EP1473145A3 EP1473145A3 (fr) 2006-10-11
EP1473145B1 true EP1473145B1 (fr) 2013-04-24

Family

ID=32695246

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04008672.0A Expired - Lifetime EP1473145B1 (fr) 2003-04-28 2004-04-10 Procédé pour le pressage d'essai de comprimés

Country Status (3)

Country Link
US (1) US7032460B2 (fr)
EP (1) EP1473145B1 (fr)
DE (1) DE10319024B3 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005007790B4 (de) 2005-02-19 2007-06-28 Fette Gmbh Verfahren und Vorrichtung zur Versuchspressung von Mehrschichttabletten oder Manteltabletten
DE102005030312B4 (de) * 2005-06-23 2011-05-05 Korsch Ag Rundläufer-Tablettiermaschine und Verfahren zur Herstellung einer Mehrschichttablette
DE102005030311B3 (de) * 2005-06-23 2006-11-23 Korsch Ag Verfahren zur Pressung von Tabletten und Rundläufer- Tablettiermaschine
DE102007052552B4 (de) * 2007-10-29 2010-01-07 Luxner, Peter, Dipl.-Ing. Verfahren und Vorrichtung zur Ermittlung von Steuer- und Regelparametern für Tablettenpressen
CN105289414A (zh) * 2015-11-13 2016-02-03 浙江中源电气成套技术有限公司 一种移动式生物质收集造粒系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6325609B1 (en) * 1998-07-29 2001-12-04 Kikusui Seisakusyo Ltd. Compression molding machine for powder material

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE569198A (fr) * 1957-07-12
DE2742572B1 (de) * 1977-09-22 1979-03-29 Fette Wilhelm Gmbh Verfahren zum Herstellen von Tabletten und Tablettenpresse
FI92145C (fi) * 1993-01-28 1994-10-10 Tensor Oy Menetelmä ja laitteisto tabletin puristamisen simuloimiseksi
US6830442B2 (en) * 2001-08-09 2004-12-14 William Alvin Cecil Rotary tablet press

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6325609B1 (en) * 1998-07-29 2001-12-04 Kikusui Seisakusyo Ltd. Compression molding machine for powder material

Also Published As

Publication number Publication date
US7032460B2 (en) 2006-04-25
DE10319024B3 (de) 2004-08-12
EP1473145A2 (fr) 2004-11-03
EP1473145A3 (fr) 2006-10-11
US20040211265A1 (en) 2004-10-28

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