EP1467782B1 - Pompe a perfusion implantable - Google Patents
Pompe a perfusion implantable Download PDFInfo
- Publication number
- EP1467782B1 EP1467782B1 EP02769837A EP02769837A EP1467782B1 EP 1467782 B1 EP1467782 B1 EP 1467782B1 EP 02769837 A EP02769837 A EP 02769837A EP 02769837 A EP02769837 A EP 02769837A EP 1467782 B1 EP1467782 B1 EP 1467782B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- infusion pump
- pump according
- pump
- catheter
- pumps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
- F04B43/09—Pumps having electric drive
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
- F04B43/09—Pumps having electric drive
- F04B43/095—Piezoelectric drive
Definitions
- the invention relates to an infusion pump according to the preamble of claim 1.
- infusion - by infusion means the introduction of liquids, for example in a human or animal body - are known various methods and devices.
- One known method is the gravitational intravenous injection of a liquid from a container which releases certain quantities of liquid per unit of time, which are supplied via a delivery line, usually a tube, to a vein.
- a delivery line usually a tube
- This method and its specific implementation for the device are known under the short name "drip", it is technically modest, reliable, but is only suitable for use in patients whose freedom of movement is subject to restrictions.
- Pumps essentially comprise a housing in which a refillable media, ie liquid or medicament container and a means for conveying the medium for connection of a delivery line are received starting from said device.
- the delivery line - also called catheter - can, for example, in the spinal room or in the Bloodstream depending on the medical indication of the recipient.
- VF pumps are pumps whose flow rate can be set per unit of time, while the flow rate per unit time is unchangeable, ie constant, for CF pumps.
- the VF pump has to promote the medium from the reservoir for connecting a catheter as a mechanical device to a battery-driven roller pump whose operating parameters such as speed, flow, etc. are electronically adjustable via a chip. In this case, the change in the operating parameters by transferring data from a data processing device, such as a computer via line and read head to the chip.
- the filling level of the storage tank and thus the consumption over a certain period of time is not measured but calculated with VF pumps. This means that the level does not indicate a refill, but after a predetermined period of time entered on the chip and independent of the remaining stock of media in the storage container is to be refilled.
- VF pumps ie flow rate deviations from a set flow rate of plus / minus 10% to 15%
- Residuals are to be withdrawn from the storage container before refilling and can not be used further. With expensive medicines this circumstance makes the operation of a pump more expensive.
- the adjustable VF pump can take advantage of it take advantage of being able to be programmed at any time according to need, this advantage is offset by the fact that the need-based programming can only be made by specially trained medical professionals, a patient must go to the data processing system due to the transfer by means of a line between the computer and the reading head or vice versa and that relatively large amounts of medication remain to be accepted as a result of inaccuracies
- a CF pump is simpler in contrast to the VF pump.
- the medium is conveyed from the reservoir to the catheter connection by means of a pressurized gas cushion, wherein a reducing device is provided between the reservoir and the catheter connection, which determines a flow rate per unit time unvariable.
- CF pumps are made according to the patient-specific recipe; only the composition of the pumped fluid can be varied, but not the delivery rate and composition as with the VF pump.
- the time of refilling is determined on the occasion of a previous filling due to the known flow rates.
- the conveying accuracy i. the accuracy of a flow rate per unit of time is higher than with VF pumps, so that residual quantity measurements do not pose the same problems as with VF pumps.
- the advantages of the simple structure and a higher delivery accuracy compared to VF pumps and the possibility of refilling by non-specialized medical personnel is therefore faced with the disadvantage of limited adjustment options.
- Most pumps of the type described are carriers, ie patients, implanted.
- the implantation takes place in the abdominal area between muscles and skin, ie in the subcutaneous fatty tissue.
- the housings of the pumps are designed as cans, usually these have a diameter of about 8 cm and a height of about 2 cm to 2.5 cm, the weight of the pump is on the order of about 200 gr. Design and weight
- the pumps lead after implantation to a cosmetic problem for the patient, as a result of the can shape and the weight of the implantation area undergoes a significant deformation.
- the pump 10 comprises a housing 11 in which the components of the pump 10 are accommodated.
- the housing 11 is formed of two equal half-shells, an upper shell 12 and a lower shell 13, which are about their free peripheral edges (edge of the upper shell 14, edge of the lower shell 15) engaged with each other, that is connected.
- the compound is liquid-tight, so that the components of the pump 10 are sealed sealed against ingress of liquid.
- the edges 14, 15 of the upper shell 12 and lower shell 13 circumscribe an ellipse, while the outer surfaces 16, 17 of the shells 12, 13 from their midpoints in the longitudinal and transverse directions of the shells 12, 13 radius-shaped to the edges 14, 15th run.
- the housing 11 of the pump 10 is arcuately deformed, wherein the deformation during implantation is made according to the shape or contour of the implantation site.
- Pumps are implanted in people in the abdominal region, between the muscle and the skin, ie in the subcutaneous fatty tissue, which absorbs the housing according to the invention without protrusions, ie, away from the implantation site.
- the upper shell 12 has expansion joints 18, which favor the arcuate deformation, ie the adaptation of the housing 11 to the shape of an implantation site.
- the upper shell 12 undergoes an expansion, while the lower shell 13 is compressed.
- the compression can be done without compensation means, but should it be necessary or expedient to compensate or facilitate compression, it may also be provided on the lower shell Kompensationsfugen.
- Joints 18 are preferably transverse to the longitudinal axis, edge to edge of the shells and are sized to stretch or collapse.
- Housing 11 are preferably made of plastics, preferably UV (ultra-violet light) curing plastics. UV-curing plastics for housing 11 are advantageous because the housing 11 can be easily plasticized before or during the implantation process, adapted to the shape of the implantation site and then UV cured again.
- the components accommodated in the housing 11 of the pump 10 include a tank 20 with a plunger 19 for filling the tank, a battery 21, an electronic Control 22, a working on the piezzoelectric principle conveyor 23 (following piezoelectric pump 23 called), conveyors, eg hoses, for conveying the liquid tank contents from the tank 20 to the piezoelectric pump 23 and from there to a side port 29 and electrical lines, the battery 21 with connect the controller 22 and the latter with the piezo pump 23.
- the tank 20 corresponds in its physical configuration to the inner cavity of the housing 11, but is shortened along its longitudinal axis by a longitudinal axis perpendicular to the circumferential edge 26, so that the other pump components find space in the interior of the housing 11.
- the tank 20, ie its walls are formed from a flexible, ie flexible, acid and alkali-resistant plastic film, which on one hand carries knobs (not shown), called the following bubble wrap. After fabrication of the tank 20, the nubbed surface of the film forms the inner surface of the tank walls. The knobs prevent the inner surfaces of the walls from sticking together when the tank 20 is empty.
- a pressure body 27 Surrounding the tank 20 of a pressure body 27.
- the pressure body 27 is formed of a compressible and expanding plastic foam.
- Its outer shape corresponds to the shape of the cavity of the housing 11, while its inner shape is dimensioned so that the tank 20 is received with abutting upper and lower tank wall recording. If the tank is filled, it expands and the upper and lower tank wall compresses the foam against the inner surface of the housing 11. By this compression, the foam of the pressure body 27 exerts on the tank 20 back pressure, which is associated with emptying of the tank 20th degrades. With the All-round pressure load of the tank 20 is achieved that it is completely emptied and ensures that the pump 10 operates in any position fluid-promoting.
- the tank 20 is filled via a valve 19 (also called plunge mandrel 19), which, starting from the upper shell 12, opens out the shell 12, the pressure body 27 and a tank wall in the tank 20.
- the plunger 19 is basically a valve that can be opened for filling in one direction, is kept closed after filling.
- the tank 20 has an outlet 30, for example, via a delivery line, e.g. a hose is connected to the input side 31 of the piezo pump 23.
- a delivery line e.g. a hose is connected to the input side 31 of the piezo pump 23.
- the input side 31 of the piezo pump 23 is constantly offered fluid.
- the piezopump 23 is a tube made of piezzoelectric crystals of at least two tube sections 23a and 23b, wherein a current or voltage can be individually applied to each tube section 23a, 23b via lines not illustrated in more detail. It is known that piezzoelectric crystals react to an applied voltage or current by changing their grids. For example, if a voltage is applied to the crystal, the grid expands, the crystal is de-energized, the grid contracts. This effect is used by the piezopump 23, in that a current or a voltage can be applied and switched off at each of the pipe sections 23a, 23b.
- the pipe sections 23a, 23b If a current or voltage is applied to the pipe sections 23a, 23b, they expand including their holes (bore opens), the power or the voltage is turned off, tighten including hole (bore closes). To generate a pumping process, the pipe sections 23a, 23b are electrically connected in opposite directions. If a current is applied to the pipe section 23a, the described expansion takes place, ie the bore of the pipe section 23a is open and can receive a fluid. During the recording no current is applied to the pipe section 23b, the pipe section 23b is closed.
- tube section 23a When the fluid intake (filling) in tube section 23a is completed, the current applied to tube section 23a is turned off and a current is applied to tube section 23b, tube section 23a closes and tube section 23b opens, the fluid is discharged from the bore of tube section 23a and flows through the bore of the pipe section 23b (discharge).
- the tube section 23b When the discharge has been completed, the tube section 23b is de-energized and the tube section 23a is energized, whereupon the pumping process repeats, whereby tube section 23b acts as a check valve in the discharge direction of successively arranged sections in the closed state.
- the invention is not limited to a piezo pump 23 with two pipe sections 23a, 23b. Piezo pumps according to the invention may be formed from more than two pipe sections. This is expedient when higher pressures of the fluid - the pressure increases in the conveying direction with each pipe section - are required. Supervention, that with increasing number of pipe sections larger and more accurate amounts of fluid can be delivered.
- the piezo pump 23 according to Fig. 7 comprises three pipe sections 24a, 24b, 24c (hereinafter sections 24a, 24b, 24c called), each of which can be activated piezzoelektrisch, for example by applying a current and deactivated. Shown are 6 circuits (circuits 1 to 6). Each section 24a, 24b, 24c is shown as a rectangle, where a rectangle without a drawn diagonal means that the section open, a rectangle with a drawn diagonal indicates that the section is closed. The arrows indicate the flow direction.
- circuit 1 a current or voltage is applied to the pump 23 and also to none of its sections 24a, 24b or 24c, the pump is thus closed without current, in which all sections are closed.
- This is a trained according to the invention security feature by preventing the failure of the battery 21, the closed sections, a penetration of body fluid into the tank 20.
- circuit 2 a current is applied to section 24a which opens section 24a and is filled from tank 20.
- the sections 24b and 24c are closed.
- the portion 24a and 24b is energized, the portion 24b opens and forms with the open portion 24a an enlarged filling space, which in addition to the filling amount in section 24a with a amount corresponding to the portion 24b is filled from the tank 20.
- the fillings in circuits 2 and 3 are predominantly by suction, whereby the suction process is triggered by the opening of the sections 24a, 24b.
- the piezo pump 23 and tank 20 are secured against pressurized body fluid by the last closed section (24c) in the direction of flow. A build-up of pressure is created by the filling amount of 24a and 24b is pressed against the closed portion 24c during the closing process of 24a (circuit 4) by the section 24c briefly opens late to section 24a.
- section 24a is closed, sections 24b and 24c are open.
- the amount of charge originally taken up in section 24a and section 24b changes under higher pressure into the sections 24b and 24c, whereby a first subset of the filling is carried away.
- circuit 5 the section closes 24 b, the closing process expresses the second subset of the piezo pump 23 from.
- circuit 6 In circuit 6 section 24c is closed and section 24a is opened again, the pump has returned to the circuit 2, for a next pumping operation, consisting of filling (circuit 2 and 3), pressure build-up (circuit 3, closing 24a and circuit 4, briefly delayed Opening), discharge (circuit 4 and 5), filling (circuit 6, identical circuit 2).
- the invention deviates from the way of transferring the pumping function to a tube consisting of at least two pipe sections, which can be piezoelectrically activated and deactivated.
- Pipes of this type are wear-free, can be operated with lower energy consumption than pumps with mechanical conveyors and pumps according to the invention are characterized in that they are much lighter than known pumps. It is particularly advantageous that the accuracy of each other following flow amounts to more than 99%. This high delivery accuracy entails that in the case of administration of drugs per delivery, smaller amounts of higher concentration than with prior art pumps may be administered.
- a pipe connects the downstream end of the pump 23 to a port 29, called Side Port 29 hereafter.
- the side port 29 passes through the lower shell 13 and to him the provided outside the housing 11 catheter 25 is connected with its upstream end A, while the downstream end B promotes depending on the indication, for example in the spinal space or the bloodstream of a recipient.
- the lower shell 13 has on its outer surface 17 a recess of wave-shaped course, in which the catheter 25 is laid.
- the side port 29 is once as a catheter connection to the lower shell 13 and as in the catheter connection formed promotional valve, which passes through the upper shell 12, in the outside of the pump 23 to the fluid flow additional fluid quantities, eg drug composition by injection (syringe with needle) are zugebbar. With the pump 23 off, the side port 29 can be used to flush the catheter and for leak testing.
- valves which consist of medically usable titanium with a valve function executive silicone filling.
- silicone filling is pierced, for example, with a hollow needle, after filling the hollow needle is withdrawn and closes the piercing opening through the silicone filling.
- Valves of this type are simple structure without moving parts and are characterized by a high reliability.
- the implantable battery 21 is electrically connected to the piezo pump 23 via an electronic controller 22 (also called control unit or controller 22).
- the task of the controller is to supply current from the battery 21 of the piezo pump 23 in a pulse shape.
- the time sequence between the pulses, the switching on and off of the stream (hereinafter called the total pump pulse) and a subsequent pump pulse is determined by a quartz watch, which triggers the pulses in accordance with certain, respectively summed oscillations via the control unit. These numbers of oscillations are retrievable and changeably stored on a data storage device (microchip).
- the frequency per unit time with which the pump pulses are triggered is called following the tract frequency.
- each piezopump 23 is individually calibrated during its manufacture, ie measured individually, whereby each piezopump 23 becomes an identifiable, patient-specific unique item with its own technical data.
- the maximum flow rate as a constant quantity in relation to the clock frequency allows the chip to calculate information on flow rate, residual quantity, etc. 32 denotes a magnetic switch which can only be activated or deactivated by means of a code and in one of the two states releases the access to the chip of the control unit 22 for the purpose of changing data.
- From the chip of the electronic controller 22 are also after implantation of the pump 10 as information retrievable the drug, the original capacity, the amount of a Einzelab manner (dose) per pump pulse, the clock frequency, the total amount of beauge kitten drug, the remaining amount in the tank 20, the duration the pump 10, the state of the battery, an identification (registration) of the pump 10 and, if programmed by the doctor, the number of boluses (medication portion) which a patient has additionally administered by means of the pump 10 to the portions pumped by the pump 10 according to the program, for example, supplemented by date and time of additional administrations.
- the above information is partly calculated or documented by the chip. Calculated, for example, the remaining amount in the tank 10, the state of emergency signals for tank refueling and warning of increased fluid consumption, total amount dispensed, etc.
- the electronic controller 22 of the pump 10 cooperates with a data processing device 33 (hereinafter called data processor 33) which communicates via a free reading head 34 with the electronic controller 22, ie its data-carrying memory or chip.
- the data processor 33 such as a conventional personal computer, is available to the physician while the patient has the read head 34, which is not implanted.
- all therapy and pump operation-specific values are determined by means of a program, stored and transmitted via the read head 34 to the chip of the control device. The transfer is accomplished by the patient holding the read head 34 on the implanted pump 10, ie, bringing the chip and read head 34 into communicative engagement with each other.
- the read head can pick up data from the chip and send it back to the data processor 33 for revision.
- control device 22 and data processor 33 remain in contact via read head 34, eg the physician can retrieve data from the chip via read head 34, compare it, change it for therapeutic purposes and forward it to the chip again .
- the data transfer from data processor 33 to read head 34 is made via telephone lines or similar telephone exchanges using the so-called tone dialing method which allocates and transmits data and tones in different pitches. This type of data transmission is possible over long distances, so that the doctor can perform therapeutic measures even with a large distanced separation to the patient.
- the reading head 34 can be combined with a signal generator 35, which triggers only the bolus delivery.
- the pump 10 according to the invention is characterized as described by two modes.
- the first mode (Mode 1) is the delivery of certain amounts within a given clock frequency
- the second mode (Mode 2) encloses the first, if necessary supplemented by the delivery of additional amounts (bolus).
- Mode 1 relies on the experience of the physician, who strives to come as close as possible to his therapeutic objective with respect to quantities, frequency of deliveries, composition of medicaments, etc. If insufficiencies, eg the blood sugar content of a diabetic patient, do not fluctuate, then it is sufficient to operate the pump 10 without bolus levies in accordance with the medical prescription (programmed insulin delivery).
- Mode 2 is preferred since Mode 2 complements or modifies the physician's prescriptions for Mode 1 to eliminate the patient's disorders. If it is assumed that Mode 1 follows medical knowledge and generally accepted rules of experience, ie includes an objectified therapeutic prescription, then Mode 2 adds a subjective sensation element that does not allow any conclusions to be drawn about the magnitude of the fluctuation fluctuations.
- a surge sensor measuring sensor (not shown) may be provided for bolus delivery which measures and adjusts excursions of set values according to mode 1 If the pump 10 is exceeded or undershot, ie the chip of the control unit 22, issued the order to promote additional quantities / reduced quantities to compensate for the fluctuation fluctuations.
- sensors may be implanted in the bloodstream in diabetes or, where indicated, worn on the body.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (12)
- Pompe à perfusion comprenant un boîtier implantable, un réservoir contenu dans le boîtier et pouvant être rempli avec un fluide muni d'une pointe d'injection et d'une sortie, d'un cathéter, d'un dispositif de refoulement disposé entre entre le réservoir et le cathéter et alimenté par une batterie, dont le débit est réglable via un contrôleur électronique, le dispositif de refoulement (23) étant configuré pour fonctionner par un principe piézoélectrique, caractérisé en ce que la surface extérieure 16 de la coque supérieure (12) du boîtier (11) comporte des joints de dilatation (18).
- Pompe à perfusion selon la revendication 1, caractérisé en ce que le dispositif de refoulement (23) est un tube (pompe piézo 23) réalisé de cristaux piézoélectriques, comprenant au moins deux portions de tube (23a) et (23b), aux portions de tube (23a) et (23b) duquel peut être appliqué un courant ou une tension électrique.
- Pompe à perfusion selon la revendication 1 ou 2, caractérisé en ce que la pompe piézo (23) refoule d'un côté d'une ouverture latérale (29) lors de la fermeture d'une des portions de tube (23a) et (23b), et qu'un cathéter (25) peut être connecté de l'autre côté de l'ouverture latérale (29).
- Pompe à perfusion selon l'une des revendications 1 à 3, caractérisée en ce que la surface extérieure (17) de la coque inférieure (13) comporte à partir de l'ouverture latérale (29), une extension ondulée dans laquelle se loge le cathéter (25) connecté à l'ouverture latérale (29).
- Pompe à perfusion selon l'une des revendications 1 à 4, caractérisée en ce que le réservoir (20) est réalisé à partir d'un film souple et comporte des bossages sur sa surface interne.
- Pompe à perfusion selon l'une des revendications 1 à 5, caractérisée en ce que le réservoir (20) est logé dans un corps de pression (27) formé de mousse en matière plastique compressible.
- Pompe à perfusion selon l'une des revendications 1 à 6, caractérisée en ce qu'un contrôleur (22) pour l'activation et la désactivation des portions de tube (23a) et (23b) est disposé entre la batterie (21) et la pompe piézo (23).
- Pompe à perfusion selon l'une des revendications 1 à 7, caractérisée en ce que l'activation ou la désactivation à lieu par application d'un courant ou d'une tension aux portions de tube (23a) et (23b).
- Pompe à perfusion selon l'une des revendications 1 à 8, caractérisée en ce que le contrôleur (22) est programmable au moyen d'un dispositif de traitement de données (33) et d'une tête de lecture (34) communiquant avec le dispositif de traitement de données (33).
- Pompe à perfusion selon l'une des revendications 1 à 9, caractérisée en ce que la communication est réalisée par une liaison téléphonique ou un dispositif de transmission téléphonique semblable.
- Pompe à perfusion selon l'une des revendications 1 à 10, caractérisée en ce que des données sont codées et transmises selon le mode en fréquence vocale.
- Pompe à perfusion selon l'une des revendications 1 à 11, caractérisée en ce que la tête de lecture (34) comporte un émetteur de signal (35) pour la délivrance d'un bolus.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH203401 | 2001-11-06 | ||
CH02034/01A CH696661A5 (de) | 2001-11-06 | 2001-11-06 | Infusionspumpe. |
PCT/CH2002/000596 WO2003039631A1 (fr) | 2001-11-06 | 2002-11-06 | Pompe a perfusion |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1467782A1 EP1467782A1 (fr) | 2004-10-20 |
EP1467782B1 true EP1467782B1 (fr) | 2010-04-14 |
Family
ID=4567227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02769837A Expired - Lifetime EP1467782B1 (fr) | 2001-11-06 | 2002-11-06 | Pompe a perfusion implantable |
Country Status (15)
Country | Link |
---|---|
US (1) | US7601148B2 (fr) |
EP (1) | EP1467782B1 (fr) |
JP (1) | JP2005507757A (fr) |
KR (1) | KR20040076858A (fr) |
CN (1) | CN100467076C (fr) |
AT (1) | ATE464081T1 (fr) |
AU (1) | AU2002363359B2 (fr) |
CA (1) | CA2469217A1 (fr) |
CH (1) | CH696661A5 (fr) |
DE (1) | DE50214373D1 (fr) |
IL (2) | IL161817A0 (fr) |
NZ (1) | NZ533357A (fr) |
RU (1) | RU2308978C2 (fr) |
WO (1) | WO2003039631A1 (fr) |
ZA (1) | ZA200404055B (fr) |
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DE102007047353A1 (de) * | 2007-10-02 | 2009-04-09 | B. Braun Melsungen Ag | Fördervorrichtung und Verfahren für die Zuführung eines Medikamenten-Lösungsgemisches |
US8105269B2 (en) | 2008-10-24 | 2012-01-31 | Baxter International Inc. | In situ tubing measurements for infusion pumps |
US8137083B2 (en) | 2009-03-11 | 2012-03-20 | Baxter International Inc. | Infusion pump actuators, system and method for controlling medical fluid flowrate |
US7806865B1 (en) * | 2009-05-20 | 2010-10-05 | Alcon Research, Ltd. | Pressurized irrigation squeeze band |
US20110152697A1 (en) * | 2009-12-18 | 2011-06-23 | K&Y Corporation | Circulatory Pressure Monitoring Using Infusion Pump Systems |
US8480622B2 (en) * | 2009-12-18 | 2013-07-09 | Sims | Infusion pump |
US20110152829A1 (en) * | 2009-12-18 | 2011-06-23 | K&Y Corporation | Patient Fluid Management System |
US8382447B2 (en) | 2009-12-31 | 2013-02-26 | Baxter International, Inc. | Shuttle pump with controlled geometry |
KR101963799B1 (ko) * | 2010-02-17 | 2019-03-29 | 플로우 포워드 메디컬, 인크. | 정맥의 전체 직경을 증가시키는 방법 및 시스템 |
JP5549285B2 (ja) | 2010-03-09 | 2014-07-16 | 株式会社リコー | 圧電素子駆動回路 |
US8567235B2 (en) | 2010-06-29 | 2013-10-29 | Baxter International Inc. | Tube measurement technique using linear actuator and pressure sensor |
KR101127126B1 (ko) * | 2011-08-31 | 2012-03-21 | 서현배 | 압전 작동 인퓨전펌프 |
CN103127584B (zh) * | 2013-03-21 | 2014-08-06 | 北京伏尔特技术有限公司 | 流量设定微调装置 |
WO2016176192A1 (fr) | 2015-04-27 | 2016-11-03 | Maguire Shane | Cathéter de pompage pour perfusion implantable |
CN104971402A (zh) * | 2015-06-25 | 2015-10-14 | 佛山可为医疗科技有限公司 | 一种精密药物输注系统 |
US10634143B2 (en) | 2015-12-23 | 2020-04-28 | Emerson Climate Technologies, Inc. | Thermal and sound optimized lattice-cored additive manufactured compressor components |
US10557464B2 (en) | 2015-12-23 | 2020-02-11 | Emerson Climate Technologies, Inc. | Lattice-cored additive manufactured compressor components with fluid delivery features |
US10982672B2 (en) | 2015-12-23 | 2021-04-20 | Emerson Climate Technologies, Inc. | High-strength light-weight lattice-cored additive manufactured compressor components |
CN206372358U (zh) * | 2016-09-13 | 2017-08-04 | 吴正才 | 新型输液仪 |
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US2891700A (en) * | 1956-11-19 | 1959-06-23 | Gestetner Ltd | Collapsible containers |
DE2421433A1 (de) * | 1974-05-03 | 1975-11-13 | Braun Melsungen Ag | Flachbeutel aus folien von thermoplastischen kunststoffen fuer biologische und therapeutische fluessigkeiten |
US3995628A (en) * | 1975-04-25 | 1976-12-07 | Travenol Laboratories, Inc. | Catheter insertion device |
DE2652026C2 (de) * | 1976-11-15 | 1983-01-05 | Siemens AG, 1000 Berlin und 8000 München | Gerät zur Infusion von Flüssigkeiten |
US4519751A (en) * | 1982-12-16 | 1985-05-28 | The Abet Group | Piezoelectric pump with internal load sensor |
FR2548431B1 (fr) | 1983-06-30 | 1985-10-25 | Thomson Csf | Dispositif a commande electrique de deplacement de fluide |
IL69431A (en) * | 1983-08-04 | 1987-12-31 | Omikron Scient Ltd | Liquid delivery system particularly useful as an implantable micro-pump for delivering insulin or other drugs |
CA1295582C (fr) * | 1983-10-17 | 1992-02-11 | Debra Cheryl Boone | Tube pour contenant comprimable |
US4822250A (en) * | 1986-03-24 | 1989-04-18 | Hitachi, Ltd. | Apparatus for transferring small amount of fluid |
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JPH02126860A (ja) * | 1988-11-08 | 1990-05-15 | Olympus Optical Co Ltd | 体内埋込み型マイクロポンプ |
CH680009A5 (en) | 1989-06-14 | 1992-05-29 | Westonbridge Int Ltd | Micro-pump-for injection of medication dose |
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US5354282A (en) * | 1990-05-04 | 1994-10-11 | Bierman Steven F | Catheter anchoring system |
US5176641A (en) * | 1991-07-08 | 1993-01-05 | Infusaid, Inc. | Implantable drug infusion reservoir having fluid impelling resilient foam member |
US5569187A (en) * | 1994-08-16 | 1996-10-29 | Texas Instruments Incorporated | Method and apparatus for wireless chemical supplying |
WO1997027829A1 (fr) * | 1996-01-31 | 1997-08-07 | The Trustees Of The University Of Pennsylvania | Dispositif d'administration de medicament commande a distance |
US6074178A (en) * | 1997-04-15 | 2000-06-13 | Face International Corp. | Piezoelectrically actuated peristaltic pump |
EP1189647B1 (fr) * | 1999-04-28 | 2003-10-22 | Sten-Olof Elfver | Systeme de distribution de medicament implantable |
US6464671B1 (en) | 1999-04-28 | 2002-10-15 | Sten-Olof Elver | Medical system |
-
2001
- 2001-11-06 CH CH02034/01A patent/CH696661A5/de not_active IP Right Cessation
-
2002
- 2002-11-06 EP EP02769837A patent/EP1467782B1/fr not_active Expired - Lifetime
- 2002-11-06 AU AU2002363359A patent/AU2002363359B2/en not_active Ceased
- 2002-11-06 NZ NZ533357A patent/NZ533357A/en unknown
- 2002-11-06 DE DE50214373T patent/DE50214373D1/de not_active Expired - Lifetime
- 2002-11-06 RU RU2004117070/14A patent/RU2308978C2/ru not_active IP Right Cessation
- 2002-11-06 KR KR10-2004-7006903A patent/KR20040076858A/ko not_active Application Discontinuation
- 2002-11-06 CA CA002469217A patent/CA2469217A1/fr not_active Abandoned
- 2002-11-06 JP JP2003541920A patent/JP2005507757A/ja active Pending
- 2002-11-06 US US10/495,069 patent/US7601148B2/en not_active Expired - Fee Related
- 2002-11-06 CN CNB028268148A patent/CN100467076C/zh not_active Expired - Fee Related
- 2002-11-06 IL IL16181702A patent/IL161817A0/xx unknown
- 2002-11-06 WO PCT/CH2002/000596 patent/WO2003039631A1/fr active Application Filing
- 2002-11-06 AT AT02769837T patent/ATE464081T1/de not_active IP Right Cessation
-
2004
- 2004-05-06 IL IL161817A patent/IL161817A/en not_active IP Right Cessation
- 2004-05-25 ZA ZA200404055A patent/ZA200404055B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20050063838A1 (en) | 2005-03-24 |
NZ533357A (en) | 2006-04-28 |
JP2005507757A (ja) | 2005-03-24 |
AU2002363359B2 (en) | 2006-07-27 |
ZA200404055B (en) | 2004-09-02 |
CN1612760A (zh) | 2005-05-04 |
RU2308978C2 (ru) | 2007-10-27 |
US7601148B2 (en) | 2009-10-13 |
RU2004117070A (ru) | 2005-03-10 |
ATE464081T1 (de) | 2010-04-15 |
CA2469217A1 (fr) | 2003-05-15 |
DE50214373D1 (de) | 2010-05-27 |
CN100467076C (zh) | 2009-03-11 |
IL161817A (en) | 2009-06-15 |
CH696661A5 (de) | 2007-09-14 |
EP1467782A1 (fr) | 2004-10-20 |
IL161817A0 (en) | 2005-11-20 |
KR20040076858A (ko) | 2004-09-03 |
WO2003039631A1 (fr) | 2003-05-15 |
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