US20060041229A1 - Flow restriction system and method for patient infusion device - Google Patents

Flow restriction system and method for patient infusion device Download PDF

Info

Publication number
US20060041229A1
US20060041229A1 US11163234 US16323405A US2006041229A1 US 20060041229 A1 US20060041229 A1 US 20060041229A1 US 11163234 US11163234 US 11163234 US 16323405 A US16323405 A US 16323405A US 2006041229 A1 US2006041229 A1 US 2006041229A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
flow
device
fluid
path
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11163234
Inventor
John Garibotto
J. Flaherty
William Gorman
Timothy Wood
Richard Moroney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insulet Corp
Original Assignee
Insulet Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/38Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401Functional features
    • A61M2005/1402Priming
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266Shape memory materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/35Communication
    • A61M2205/3576Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00Ancillary equipment
    • A61M2209/04Tools for specific apparatus
    • A61M2209/045Tools for specific apparatus for filling, e.g. for filling reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M5/003Kits for diabetics

Abstract

A device for delivering fluid, such as insulin for example, to a patient. The device includes a flow path having an exit port assembly adapted to connect to a transcutaneous patient access tool, and a reservoir connected to the exit port assembly. The device also includes a flow restriction system having an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly. Among other features and advantages, the flow restriction system of the present invention allows the flow path of the fluid delivery device to be purged of air, or “primed” prior to operation, such that desired volumes of fluid can be accurately delivered by the device.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    The present application is a divisonal of co-pending U.S. patent application Ser. No. 10/198,690, filed on Jul. 16, 2002, which is assigned to the assignee of the present application and incorporated herein by reference.
  • FIELD OF THE INVENTION
  • [0002]
    The present invention relates generally to medical devices, systems and methods, and more particularly to small, low cost, portable infusion devices and methods that are useable to achieve precise, sophisticated, and programmable flow patterns for the delivery of therapeutic liquids such as insulin to a mammalian patient. Even more particularly, the present invention is directed to fluid flow restriction systems and methods for an infusion device. Among other benefits and features, the fluid flow restriction systems and methods of the present invention ensure adequate priming of infusion devices prior to use, and the delivery of accurate volumes of fluid from the infusion devices during their use.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Today, there are numerous diseases and other physical ailments that are treated by various medicines including pharmaceuticals, nutritional formulas, biologically derived or active agents, hormonal and gene based material and other substances in both solid or liquid form. In the delivery of these medicines, it is often desirable to bypass the digestive system of a mammalian patient to avoid degradation of the active ingredients caused by the catalytic enzymes in the digestive tract and liver. Delivery of a medicine other than by way of the intestines is known as parenteral delivery. Parenteral delivery of various drugs in liquid form is often desired to enhance the effect of the substance being delivered, insuring that the unaltered medicine reaches its intended site at a significant concentration. Also, undesired side effects associated with other routes of delivery, such as systemic toxicity, can potentially be avoided.
  • [0004]
    Often, a medicine may only be available in a liquid form, or the liquid version may have desirable characteristics that cannot be achieved with solid or pill form. Delivery of liquid medicines may best be accomplished by infusing directly into the cardiovascular system via veins or arteries, into the subcutaneous tissue or directly into organs, tumors, cavities, bones or other site specific locations within the body. Parenteral delivery of liquid medicines into the body is often accomplished by administering bolus injections using a needle and reservoir, or continuously by gravity driven dispensers or transdermal patch technologies. Bolus injections often imperfectly match the clinical needs of the patient, and usually require larger individual doses than are desired at the specific time they are given. Continuous delivery of medicine through gravity feed systems compromise the patient's mobility and lifestyle, and limit the therapy to simplistic flow rates and profiles. Transdermal patches have special requirements of the medicine being delivered, particularly as it relates to the molecular structure, and similar to gravity feed systems, the control of the drug administration is severely limited.
  • [0005]
    Ambulatory infusion pumps have been developed for delivering liquid medicaments to a patient. These infusion devices have the ability to offer sophisticated fluid delivery profiles accomplishing bolus requirements, continuous infusion and variable flow rate delivery. These infusion capabilities usually result in better efficacy of the drug and therapy and less toxicity to the patient's system. An example of a use of an ambulatory infusion pump is for the delivery of insulin for the treatment of diabetes mellitus. These pumps can deliver insulin on a continuous basal basis as well as a bolus basis as is disclosed in U.S. Pat. No. 4,498,843 to Schneider et al.
  • [0006]
    The ambulatory pumps often work with a reservoir to contain the liquid medicine, such as a cartridge, a syringe or an IV bag, and use electro-mechanical pumping or metering technology to deliver the medication to the patient via tubing from the infusion device to a needle that is inserted transcutaneously, or through the skin of the patient. The devices allow control and programming via electromechanical buttons or switches located on the housing of the device, and accessed by the patient or clinician. The devices include visual feedback via text or graphic screens, such as liquid crystal displays known as LCD's, and may include alert or warning lights and audio or vibration signals and alarms. The device can be worn in a harness or pocket or strapped to the body of the patient. Currently available ambulatory infusion devices are expensive, difficult to program and prepare for infusion, and tend to be bulky, heavy and very fragile. Filling these devices can be difficult and require the patient to carry both the intended medication as well as filling accessories. The devices require specialized care, maintenance, and cleaning to assure proper functionality and safety for their intended long term use. Due to the high cost of existing devices, healthcare providers limit the patient populations approved to use the devices and therapies for which the devices can be used.
  • [0007]
    Clearly, therefore, there was a need for a programmable and adjustable infusion system that is precise and reliable and can offer clinicians and patients a small, low cost, light-weight, easy-to-use alternative for parenteral delivery of liquid medicines. In response, the applicant of the present application provided a small, low cost, light-weight, easy-to-use device for delivering liquid medicines to a patient. The device, which is described in detail in co-pending U.S. application Ser. No. 09/943,992, filed on Aug. 31, 2001, includes an exit port, a dispenser for causing fluid from a reservoir to flow to the exit port, a local processor programmed to cause a flow of fluid to the exit port based on flow instructions from a separate, remote control device, and a wireless receiver connected to the local processor for receiving the flow instructions. To reduce the size, complexity and costs of the device, the device is provided with a housing that is free of user input components, such as a keypad, for providing flow instructions to the local processor. Such devices for delivering liquid medicines to a patient are preferably purged of air, or “primed” prior to operation such that desired volumes of fluid are accurately delivered by the devices. What is still desired, therefore, are new and improved devices for delivering fluid to a patient. Preferably, the fluid delivery devices will be simple in design, and inexpensive and easy to manufacture, in order to further reduce the size, complexity and costs of the devices, such that the devices lend themselves to being small and disposable in nature. In addition, the fluid delivery device will preferably include a flow restriction system and method that primes the devices prior to operation.
  • SUMMARY OF THE INVENTION
  • [0008]
    The present invention provides a device for delivering fluid, such as insulin for example, to a patient. The device includes a flow path having an exit port assembly adapted to connect to a transcutaneous patient access tool (e.g., needle), and a reservoir connected to the exit port assembly. The device also includes a flow restriction system having an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly. Among other features and advantages, the flow restriction system of the present invention allows the flow path of the fluid delivery device to be purged of air, or “primed” prior to operation, such that desired volumes of fluid can be accurately delivered by the device. According to one aspect of the present invention, the flow restrictor of the flow restriction system comprises an outlet plug removably connected to the exit port assembly to prevent fluid from exiting the flow path through the exit port assembly. According to another aspect, the exit port assembly of the fluid delivery device includes a transcutaneous patient access tool and the outlet plug is removably connected to the access tool. According to a further aspect, the transcutaneous patient access tool comprises a needle having a distal end for insertion into a patient and the outlet plug is removably connected to the distal end of the needle.
  • [0009]
    According to another aspect of the present invention, the air removal filter of the flow restriction system comprises at least a portion of the outlet plug allowing air to exit the flow path through the exit port assembly. According to an additional aspect, the air removal filter of the outlet plug comprises one of PTFE and polyethylene. According to a further aspect, the air removal filter of the outlet plug is provided with predetermined physical properties (e.g., pore size and/or thickness) such that the filter expands upon the flow path being substantially primed. According to yet another aspect, the air bubble removal filter of the outlet plug comprises needle septum material. According to an additional aspect of the present invention, the flow restriction system further comprises a second air removal filter positioned between the fill port and the reservoir. According to another aspect, the flow restriction system further comprises a second flow restrictor positioned between the second air removal filter and the reservoir. According to a further aspect of the present invention, the flow restriction system also includes a sensor assembly monitoring fluid flow conditions within the flow path.
  • [0010]
    According to one aspect, the sensor assembly includes a resilient diaphragm having opposing first and second surfaces, with the first surface of the diaphragm positioned against the flow path, a chamber wall positioned adjacent the second surface of the diaphragm and defining a sensor chamber adjacent the second surface of the diaphragm, and at least one sensor arranged to provide a signal when the second surface of the diaphragm expands into the chamber. According to an additional aspect, the sensor assembly is adapted to provide a signal to the processor when the flow path is primed. The present invention also provides a method for restricting fluid flow in a flow path of a fluid delivery device having an exit port assembly adapted to connect to a transcutaneous patient access tool. The method includes preventing fluid from exiting the flow path, allowing air to exit the flow path at an air removal point within the flow path, and restricting fluid flow through the flow path between the air removal point and the exit port assembly. These aspects of the invention together with additional features and advantages thereof may best be understood by reference to the following detailed descriptions and examples taken in connection with the accompanying illustrated drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0011]
    FIG. 1 is a perspective view of a first exemplary embodiment of a fluid delivery device constructed in accordance with the present invention shown secured on a patient, and a remote control device for use with the fluid delivery device (the remote control device being enlarged with respect to the patient and the fluid delivery device for purposes of illustration);
  • [0012]
    FIG. 2 is an enlarged top sectional view of the fluid delivery device of FIG. 1;
  • [0013]
    FIG. 3 is an enlarged side elevation view, partially cut-away, of the fluid delivery device of FIG. 1;
  • [0014]
    FIG. 4 is an enlarged bottom plan view of the fluid delivery device of FIG. 1;
  • [0015]
    FIG. 5 is an enlarged top sectional view of another exemplary embodiment of a fluid delivery device constructed in accordance with the present invention;
  • [0016]
    FIG. 5 a is a further enlarged sectional view of an exemplary embodiment of a flow sensor assembly of the fluid delivery device of FIG. 5;
  • [0017]
    FIG. 6 is a graph illustrating an exemplary embodiment of a method of restricting flow according to the present invention as carried out by the flow sensor assembly of the fluid delivery device of FIGS. 5 and 5 a;
  • [0018]
    FIG. 7 is a sectional view of another exemplary embodiment of a flow restriction system constructed in accordance with the present invention;
  • [0019]
    FIG. 8 is an enlarged sectional view of a portion of the exemplary embodiment of a flow restriction system contained in circle 8 of FIG. 7;
  • [0020]
    FIG. 9 is an enlarged sectional view of an exemplary embodiment of an outlet plug constructed in accordance with the present invention for use as part of the flow restriction system of FIG. 4 a;
  • [0021]
    FIG. 10 a is a further enlarged sectional view of the outlet plug of FIG. 9;
  • [0022]
    FIG. 10 b is an enlarged sectional view of the outlet plug of FIG. 9 shown received on an exit port cannula of the fluid delivery device, after the device has been filled with fluid and purged of air;
  • [0023]
    FIG. 11 is a sectional view of an additional exemplary embodiment of a flow restriction system constructed in accordance with the present invention;
  • [0024]
    FIG. 12 is a side elevation view, partially cut-away, showing another exemplary embodiment of outlet plug constructed in accordance with the present invention, received on an exit port cannula of a fluid delivery device with a needle of a syringe inserted into the outlet plug for injecting fluid into the exit port cannula and the fluid delivery device;
  • [0025]
    FIG. 13 is a side elevation view, partially cut-away, showing an additional exemplary embodiment of outlet plug constructed in accordance with the present invention, received on an exit port cannula;
  • [0026]
    FIG. 14 is a side elevation view, partially cut-away, showing a further exemplary embodiment of outlet plug constructed in accordance with the present invention, received on an exit port cannula;
  • [0027]
    FIGS. 15 a and 15 b are top plan views of another exemplary embodiment of an outlet plug constructed in accordance with the present invention, respectively showing an air bubble filter of the outlet plug before and after expansion;
  • [0028]
    FIGS. 16 a and 16 b are side sectional views of another exemplary embodiment of an outlet plug constructed in accordance with the present invention, respectively showing an air bubble filter of the outlet plug before and after expansion;
  • [0029]
    FIG. 17 is a side elevation view showing another exemplary embodiment of outlet plug constructed in accordance with the present invention, received on an exit port cannula of a fluid delivery device;
  • [0030]
    FIG. 18 is a side elevation view showing an additional exemplary embodiment of outlet plug constructed in accordance with the present invention, received on an exit port cannula of a fluid delivery device;
  • [0031]
    FIG. 19 is a side elevation view, partially cut-away, showing an exemplary embodiment of a package constructed in accordance with the present invention, and containing a fluid delivery device;
  • [0032]
    FIG. 20 a is a side elevation view, partially cut-away, showing an exemplary embodiment of a fluid delivery device and an outlet plug constructed in accordance with the present invention;
  • [0033]
    FIG. 20 b is a side elevation view, partially cut-away, showing the outlet plug removed from the fluid delivery device of FIG. 20 a;
  • [0034]
    FIG. 21 is a representation of an exemplary embodiment of a flow path constructed in accordance with the present invention for use in a fluid delivery device;
  • [0035]
    FIG. 22 is a side elevation view, partially cut-away, showing an exemplary embodiment of an exit port assembly and an outlet plug constructed in accordance with the present invention for use in a fluid delivery device;
  • [0036]
    FIG. 23 is a sectional view showing an exemplary embodiment of a fluid delivery device and an outlet plug constructed in accordance with the present invention;
  • [0037]
    FIG. 24 is an enlarged sectional view of a pressure sensor of the fluid delivery device of FIG. 23;
  • [0038]
    FIG. 25 is an enlarged sectional view of the outlet plug of FIG. 23;
  • [0039]
    FIG. 26 is a sectional view showing the outlet plug of FIG. 23 attached to an exit port assembly of the fluid delivery device of FIG. 23; and
  • [0040]
    FIG. 27 is an enlarged sectional view of the outlet plug attached to the exit port assembly contained in circle 27 of FIG. 26.
  • [0041]
    Like reference characters designate identical or corresponding components and units throughout the several views.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0042]
    Referring first to FIG. 2, there is illustrated a fluid delivery device 10 including a flow restriction system 200 constructed in accordance with the present invention. The flow restriction system 200 operates to substantially prime (i.e., purge of air) a flow path 12 of the fluid delivery device 10 prior to operation of the device 10, to ensure that a desired volume of fluid is accurately delivered by the device 10 during operation.
  • [0043]
    The fluid delivery device 10 of FIG. 2, and which is also shown in FIGS. 3 and 4, can be used for the delivery of fluids to a person or animal. The types of liquids that can be delivered by the fluid delivery device 10 include, but are not limited to, insulin, antibiotics, nutritional fluids, total parenteral nutrition or TPN, analgesics, morphine, hormones or hormonal drugs, gene therapy drugs, anticoagulants, analgesics, cardiovascular medications, AZT or chemotherapeutics. The types of medical conditions that the fluid delivery device 10 might be used to treat include, but are not limited to, diabetes, cardiovascular disease, pain, chronic pain, cancer, AIDS, neurological diseases, Alzheimer's Disease, ALS, Hepatitis, Parkinson's Disease or spasticity. In addition, it should be understood that the flow restriction assembly 200 according to the present invention can be used with fluid delivery devices other than those used for the delivery of fluids to persons or animals.
  • [0044]
    The flow path 12 of the fluid delivery device 10, as shown in FIG. 2, generally includes a reservoir 30 for receiving and holding the fluid to be delivered by the device 10, an exit port assembly 70 connected to the reservoir, and a fill port connected to the reservoir. The fluid delivery device 10 also includes a dispenser 40 for causing fluid from the reservoir 30 to flow to the exit port assembly 70.
  • [0045]
    The volume of the reservoir 30 is chosen to best suit the therapeutic application of the fluid delivery device 10 impacted by such factors as available concentrations of medicinal fluids to be delivered, acceptable times between refills or disposal of the fluid delivery device 10, size constraints and other factors. The reservoir 30 may be prefilled by the device manufacturer or a cooperating drug manufacturer, or may include external filling means, such as a fill port 90 having needle insertion septum or a Luer connector, for example. In addition, the device 10 can be provided with a removable reservoir.
  • [0046]
    The exit port assembly 70 can include elements to penetrate the skin of the patient, such that the entire volume of the flow path 12 of the fluid delivery device 10 is predetermined. For example, in the exemplary embodiment shown in FIG. 3, a needle-connection tubing terminating in a skin penetrating cannula 72 is provided as an integral part of the exit port assembly 70. The exit port assembly 70 can further be provided with injection means, such as a spring-biased mechanism driven by a shaped memory element, to inject the skin penetrating cannula 72 into a patient when the fluid delivery device 10 is correctly positioned on the patient. For example, if the cannula is a flexible tube, a rigid penetrator within the lumen of the tube can be driven through the skin by the injection means and then withdrawn, leaving the soft cannula in place in the subcutaneous tissue of the patient or other internal site.
  • [0047]
    Examples of injection means for the exit port assembly are shown in co-pending U.S. patent application Ser. No. 10/037,902, filed on Nov. 9, 2001 (Atty. Docket No. INSL-114), and entitled TRANSCUTANEOUS DELIVERY MEANS, and U.S. patent application Ser. No. 10/128,206, filed on Apr. 23, 2002 (Atty. Docket No. INSL-121), and entitled TRANSCUTANEOUS FLUID DELIVERY SYSTEM, both of which are assigned to the assignee of the present application and incorporated herein by reference.
  • [0048]
    Alternatively, the injection means may be removable soon after transcutaneous penetration. In addition, the exit port assembly 70 can simply be adapted to connect with a Luer connector for example, to a separate, standard infusion device that includes a skin penetrating cannula. The exit port assembly 70 can alternatively be adapted to connect through tubing to another medical device.
  • [0049]
    It should be understood that, as used herein, the term “flow path” 12 is meant to include all portions of the fluid delivery device 10 that contain therapeutic fluid for delivery to a patient, e.g., all portions between the fill port 90 of the reservoir 30 to the tip of the needle 72 of the exit port assembly 72.
  • [0050]
    The fluid delivery device 10 also includes a processor or electronic microcontroller (hereinafter referred to as the “local” processor) 50 connected to the dispenser 40. The local processor 50 is programmed to cause a flow of fluid to the exit port assembly 70 based on flow instructions from a separate, remote control device 100, an example of which is shown in FIG. 1.
  • [0051]
    Referring also to FIG. 1, the fluid delivery device 10 further includes a wireless receiver 60 connected to the local processor 50 for receiving flow instructions from a separate, remote control device 100 and delivering the flow instructions to the local processor 50. The device 10 also includes a housing 20 containing the exit port assembly 70, the reservoir 30, the dispenser 40, the local processor 50, and the wireless receiver 60.
  • [0052]
    As shown best in FIGS. 3 and 4, the housing 20 of the fluid delivery device 10 is free of user input components for providing flow instructions to the local processor 50, such as electromechanical switches or buttons on an outer surface of the housing 20, or interfaces otherwise accessible to a user to adjust the programmed flow rate through the local processor 50. The lack of user input components allows the size, complexity and costs of the device 10 to be substantially reduced so that the device 10 lends itself to being small and disposable in nature. Examples of such devices are disclosed in co-pending U.S. patent application Ser. No. 09/943,992, filed on Aug. 31, 2001 (Atty. Docket No. INSL-110), and entitled DEVICES, SYSTEMS AND METHODS FOR PATIENT INFUSION, which is assigned to the assignee of the present application and has previously been incorporated herein by reference.
  • [0053]
    In order to program, adjust the programming of, or otherwise communicate user inputs to the local processor 50, the fluid delivery device 10 includes the wireless communication element, or receiver 60 for receiving the user inputs from the separate, remote control device 100 of FIG. 1. Signals can be sent via a communication element (not shown) of the remote control device 100, which can include or be connected to an antenna 130, shown in FIG. 1 as being external to the device 100.
  • [0054]
    The remote control device 100 has user input components, including an array of electromechanical switches, such as the membrane keypad 120 shown. The control device 100 also includes user output components, including a visual display, such as a liquid crystal display (LCD) 110. Alternatively, the control device can be provided with a touch screen for both user input and output. Although not shown in FIG. 1, the remote control device 100 has its own processor (hereinafter referred to as the “remote” processor) connected to the membrane keypad 120 and the LCD 110. The remote processor receives the user inputs from the membrane keypad 120 and provides “flow” instructions for transmission to the fluid delivery device 10, and provides information to the LCD 110. Since the remote control device 100 also includes a visual display 110, the fluid delivery device 10 can be void of an information screen, further reducing the size, complexity and costs of the device 10.
  • [0055]
    The communication element 60 of the device 10 preferably receives electronic communication from the remote control device 100 using radio frequency or other wireless communication standards and protocols. In a preferred embodiment, the communication element 60 is a two-way communication element, including a receiver and a transmitter, for allowing the fluid delivery device 10 to send information back to the remote control device 100. In such an embodiment, the remote control device 100 also includes an integral communication element comprising a receiver and a transmitter, for allowing the remote control device 100 to receive the information sent by the fluid delivery device 10.
  • [0056]
    The local processor 50 of the device 10 contains all the computer programs and electronic circuitry needed to allow a user to program the desired flow patterns and adjust the program as necessary. Such circuitry can include one or more microprocessors, digital and analog integrated circuits, resistors, capacitors, transistors and other semiconductors and other electronic components known to those skilled in the art. The local processor 50 also includes programming, electronic circuitry and memory to properly activate the dispenser 40 at the needed time intervals.
  • [0057]
    In the exemplary embodiment of FIG. 2, the device 10 includes a power supply 80, such as a battery or capacitor, for supplying power to the local processor 50. The power supply 80 is preferably integrated into the fluid delivery device 10, but can be provided as replaceable, e.g., a replaceable battery.
  • [0058]
    Although not shown, the device 10 can include sensors or transducers such as a reservoir volume transducer or a reservoir pressure transducer, for transmitting information to the local processor 50 to indicate how and when to activate the dispenser 40, or to indicate other parameters determining flow, blockage in flow path, contact sensors, rotary motion or other motion indicators, as well as conditions such as the reservoir 30 being empty or leaking, or the dispensing of too much or too little fluid from the reservoir, etc.
  • [0059]
    As shown in FIGS. 3 and 4, the device 10 can also be provided with an adhesive layer 22 on the outer surface of the housing 20 for securing the device 10 directly to the skin of a patient, as illustrated in FIG. 1. The adhesive layer 22 is provided on an external “bottom” surface of the housing 20. The adhesive layer is also preferably provided in a continuous ring encircling the port 24 of the exit port assembly 70 in order to provide a protective seal around the penetrated skin to prevent the penetrated skin from becoming dirty when the cannula 72 of the exit port assembly 70 extends through the skin. It is preferably that the fill port 90 extend through the bottom surface of the housing 20 and be surrounded by the adhesive layer 22 to discourage and prevent filling and re-filling of the fluid delivery device 10 when the device is attached to a patient's skin. The housing 20 can be made from flexible material, or can be provided with flexible hinged sections that allow the fluid delivery device 10 to flex during patient movement to prevent detachment and aid in patient comfort.
  • [0060]
    In the exemplary embodiment of FIGS. 4 and 5, the device 10 is provided with a non-pressurized reservoir 30, and the dispenser 40 is adapted to control flow from the reservoir 30 by driving or pumping the fluid from the reservoir to the exit port assembly.
  • [0061]
    Examples of such “driving or pumping” dispensers are shown in co-pending U.S. patent application Ser. No. 09/955,623, filed on Sep. 19, 2001 (Atty. Docket No. INSL-117), and entitled PLUNGER FOR PATIENT INFUSION DEVICE, which is assigned to the assignee of the present application and incorporated herein by reference. Other examples of dispensers are shown in co-pending U.S. patent application Ser. No. 10/128,205, filed on Apr. 23, 2002 (Atty. Docket No. INSL-122), and entitled DISPENSER FOR PATIENT INFUSION DEVICE, which is assigned to the assignee of the present application and incorporated herein by reference, and co-pending U.S. patent application Ser. No. 10/128,203, filed on Apr. 23, 2002 (Atty. Docket No. INSL-123), and entitled DISPENSER FOR PATIENT INFUSION DEVICE, which is assigned to the assignee of the present application and incorporated herein by reference. Further examples of dispensers are shown in co-pending U.S. patent application Ser. No. ______, filed on Jun. 9, 2002 (Atty. Docket No. INSL-124), and entitled PLUNGER FOR PATIENT INFUSION DEVICE, which is assigned to the assignee of the present application and incorporated herein by reference, and in co-pending U.S. patent application Ser. No. ______, filed on Jun. 9, 2002 (Atty. Docket No. INSL-125), and entitled PLUNGER FOR PATIENT INFUSION DEVICE, which is also assigned to the assignee of the present application and incorporated herein by reference.
  • [0062]
    In the embodiment shown in FIGS. 4 and 5, the reservoir 30 includes a side wall 32 extending towards an outlet 36 connected to the exit port assembly 70. A threaded lead screw 42 is received in the reservoir 30 and extends towards the outlet 36 of the reservoir 30 generally parallel with the side wall 32 of the reservoir, and a plunger 44 is secured to an end of the lead screw 42. The lead screw 42, the plunger 44 and the reservoir 30 are adapted such that a fluid-tight seal is formed between the plunger and the lead screw and a fluid-tight seal is formed between the plunger and the side wall 32 of the reservoir, so that movement of the plunger towards the outlet 36 of the reservoir 30 forces fluid through the outlet 36 to the exit port assembly 70.
  • [0063]
    The dispenser 40 causes fluid flow by causing linear movement of the lead screw 42 and the plunger 44 towards the outlet 36 of the reservoir 30. Although not shown, the dispenser 40 can include an elongated shape memory element connected to the local processor 50 and having a changeable length decreasing from an uncharged length to a charged length when at least one charge is applied to the shape memory element. The shape memory element is operatively connected to the plunger 44 such that the changeable length of the shape memory element causes the plunger 44 to move along the side wall 32 of the reservoir 30.
  • [0064]
    In the embodiment shown, the dispenser 40 includes a rotatable gear 46 linearly fixed with respect to the reservoir 30. The gear 46 is coaxially mounted with respect to the lead screw 42, and is threadedly engaged with the lead screw 42, such that rotation of the gear 46 causes linear movement of the lead screw 42. In particular, the lead screw 42 and the gear 46 are adapted such that rotation of the gear 46 in a first direction causes linear movement of the lead screw 42 and the plunger 44 towards the outlet 36 of the reservoir 30.
  • [0065]
    The dispenser 40 further includes a finger 48 for engaging radially extending teeth of the gear 46, wherein the finger 48 and the gear 46 are adapted such that linear movement of the finger 48 in a first direction adjacent the gear 46 causes rotation of the gear while linear movement of the finger 48 in a second direction adjacent the gear 46 causes no rotation of the gear. Although not shown, the elongated shape memory element is connected to the finger 48 such that the changeable length of the shape memory element decreasing from an uncharged length to a charged length causes linear movement of the finger 48 in one of the first and the second directions. The dispenser 40 can also include an actuation element, such as a compression spring, connected to the finger 48 for causing linear movement of the finger in the first direction. Examples of such dispensers are shown in co-pending U.S. patent application Ser. No. 10/128,205, filed on Apr. 23, 2002 (Atty. Docket No. INSL-122), which has already been incorporated herein by reference.
  • [0066]
    Although not shown, the gear 46 can be further configured to be released from the lead screw 42 to allow the lead screw 42 and the plunger 44 to be linearly moved away from the outlet 36 of the reservoir 30 during filling of the reservoir. An example of such a releasable gear is also shown in co-pending U.S. patent application Ser. No. 10/128,205, filed on Apr. 23, 2002 (Atty. Docket No. INSL-122), which has already been incorporated herein by reference.
  • [0067]
    It should be understood, however, that other types of dispensers can also be used with a device incorporating a flow restriction assembly 200 of the present invention. For example, the device can be provided with a pressurized reservoir and a dispenser that does not create a driving or pumping force, but rather acts as a metering device, allowing pulses of fluid to pass from the pressurized reservoir, through the dispenser, to the exit port assembly 70. Examples of such “metering” dispensers are shown in co-pending U.S. patent application Ser. No. 09/977,434, filed Oct. 12, 2001 (Atty. Docket No. INSL-116), and entitled LAMINATED PATIENT INFUSION DEVICE, which is assigned to the assignee of the present application and incorporated herein by reference. In any event, the dispenser is controlled by the local processor 50, which includes electronic programming, controls, and circuitry to allow sophisticated fluid delivery programming and control of the dispenser.
  • [0068]
    Referring now to FIGS. 2 through 4, an exemplary embodiment of the flow restriction system 200 of the present invention is shown. The flow restriction system 200 generally includes an air removal filter communicating with the flow path 12 and allowing air to exit the flow path 12 and preventing fluid from exiting the flow path 12, and a flow restrictor positioned within the flow path 12 between the air removal filter and the exit port assembly 70 (i.e., downstream of the filter). Among other features and advantages, the flow restriction system 200 of the present invention allows the flow path 12 of the fluid delivery device 10 to be purged of air, or “primed” prior to operation, such that desired volumes of fluid can be accurately delivered by the device 10. In particular, the air removal filter of the flow restriction system 200 removes air from the flow path 12, while the flow restrictor of the flow restriction system 200 elevates pressure within the flow path 12 to ensure that substantially all air within the flow path 12 is forced out of the air removal filter.
  • [0069]
    In the exemplary embodiment of FIGS. 2 through 4, the flow restrictor and the air removal filter of the flow restriction system 200 are combined in a single outlet plug 202 fitted to the port 24 of the exit port assembly 70. The outlet plug 202 is unitarily formed of a material that allows the passage of air but prevents the passage of fluid, such as an ultrahigh molecular weight polyethylene in sinstered porous form, a porous ceramic, a hydrophobic gel, a woven or non-woven polytetrafluoroethylene (PTFE) such as Teflon®, or woven fabric material having very small openings (e.g., 0.02 microns) such as Gortex®.
  • [0070]
    In the exemplary embodiment of FIGS. 2 through 4, the flow restrictor and the air removal filter of the flow restriction system 200 are positioned between the reservoir 30 and the outlet port assembly 70. However, the flow restrictor and the air removal filter of the flow restriction system 200 could be positioned before the reservoir 30, as long as the flow restrictor is positioned downstream of the air removal filter.
  • [0071]
    The removable outlet plug 202 prevents fluid leakage from the flow path 12 prior to use, e.g., during storage and during priming when filled by a user. The outlet plug 202 may also maintain the cannula 72 of the exit port assembly 70 in a sterile state prior to use. The outlet plug 202 is removed by a user prior to attaching the fluid delivery device 10 to a patient's skin surface. In the embodiment shown, the cannula 72 of the exit port assembly 70 is extendable through the port 22 in the housing 20 of the fluid delivery device 10 to be inserted into the skin of a patient. The outlet plug 202 is removably secured to the outer surface of the housing 20 over the port 22, such that the outlet plug 202 prevents fluid from exiting the flow path 12.
  • [0072]
    FIG. 5 shows another exemplary embodiment of a fluid delivery device 10 including a flow restriction system 300 constructed in accordance with the present invention. The system 300 of FIG. 5 is similar to the system 200 of FIGS. 2 through 4 such that similar elements have the same reference numeral. The flow restriction system 300 of FIG. 5, however, further includes a flow sensor assembly 310 that provides an indication of fluid pressure within the flow path 12, so that conditions within the flow path 12 can be determined during a filling process. In particular, the flow sensor assembly 310 can be used to provide an indication of when the flow path 12 is full and when the flow path 12 becomes primed.
  • [0073]
    In the exemplary embodiment, as also shown in FIG. 5 a, the flow sensor assembly 310 comprises a resilient diaphragm 320 having opposing first and second surfaces 322, 324, with the first surface 322 positioned against the flow path 12 of the device 10, and a chamber wall 326 positioned adjacent the second surface 324 of the diaphragm. The diaphragm 320 is made from a suitably expandable yet resilient material, such as rubber or a synthetic rubber. The chamber wall 326 is adapted such that an enclosed chamber 328 is defined between the chamber wall 326 and the second surface 324 of the diaphragm 320. Preferably, the chamber 328 is provided with a predetermined volume. Although not shown, the chamber 328 can also be provided with a relief port for allowing air to escape the chamber upon expansion of the diaphragm 320.
  • [0074]
    The diaphragm 320 and the chamber 328 are arranged and adapted such that the amount of expansion and the duration of the expansion of the diaphragm into the chamber can be used to determine when the flow path 12 becomes substantially primed upon being filled through the fill port 90. The sensor assembly 310 also includes at least one sensor 330 arranged to provide a signal when the second surface 324 of the diaphragm 320 expands into the chamber 328 in response to at least one predetermined fluid flow condition occurring in the flow path 12. For example, the sensor 330 can be arranged to determine when the second surface 324 of the diaphragm 320 expands fully into the chamber 328 and contacts the chamber wall 326.
  • [0075]
    The sensor 330 can comprise any device for determining and providing an indication of the position of the diaphragm 320 in the chamber 328. For example, the sensor can comprise one of a contact or pressure switch, a magnetic Hall effect sensor, a strain gage, and a density gage. In the embodiment of FIG. 5 a, the sensor comprises three open circuits 330 a, 330 b, 330 c, which each have their own primary leads 332 a, 332 b, 332 c and share a secondary lead 334. The secondary lead 334 is positioned on the second surface 324 of the diaphragm 320, while the primary leads 332 a, 332 b, 332 c are positioned on the chamber wall 326 at different points from the diaphragm 320. During expansion of the diaphragm 320 into the chamber 328, the secondary lead 334 of the diaphragm 320 eventually contacts each of primary leads 332 a, 332 b, 332 c, and successively closes the circuits 330 a, 330 b, 330 c.
  • [0076]
    In the embodiment 300 of the invention illustrated in FIGS. 2, the processor 50 of the fluid delivery device 10 also acts as the processor for the sensor assembly 300 and is connected to the open circuits 330 a, 330 b, 330 c. During expansion of the diaphragm 320 into the chamber 328, the circuits 330 a, 330 b, 330 c are successively closed to provide “signals” to the processor 50. Alternatively, the sensor assembly 300 can be provided with its own, separate processor programmed to operate in accordance with the present invention. In addition, the sensors 330 a, 330 b, 330 c can simply be connected to an alarm(s), such as a light emitting diode or an electronic sound maker, and which is activated upon the circuits 330 a, 330 b, 330 c being closed. In this manner, a user can simply receive a visual or an audible alarm signal upon full expansion of the diaphragm 320 into the chamber 328 to close the circuits 330 a, 330 b, 330 c.
  • [0077]
    FIG. 6 illustrates an exemplary embodiment of a method of determining when the flow path 12 is primed in accordance with the present invention and as carried out by the processor 50. FIG. 6 is a graph of pressure versus time illustrating pressure within the flow path while the flow path is being filled by a user. The pressure level “a” illustrated in the graph is produced upon the second surface 324 of the diaphragm 320 expanding partly into the chamber 328 and closing the first sensor circuit 330 a, shown in FIG. 5 a. Upon receiving signal “a” from the first sensor circuit 330 a, the processor 50 is programmed to send a signal to the remote control device 100 indicating that the flow delivery device 10 is being filled. Although not shown, the remote control device 100 can include an alarm, such as an audible or visual alarm, that the remote processor of the remote control device 100 activates upon receiving the signal from the local processor 50. In addition, the fluid delivery device 10 itself can be provided with an alarm, such as a light emitting diode or electronic buzzer, connected to the local processor 50 for activation at least initially when the flow path is being filled by a user.
  • [0078]
    The pressure level “b” illustrated in the graph is produced upon the second surface 324 of the diaphragm 320 further expanding into the chamber 328 and closing the second sensor circuit 330 b. Upon receiving signal “b” from the second sensor circuit 330 b, the processor 50 is programmed to send a signal to the remote control device 100 indicating that the plunger 44 of the flow delivery device 10 has been fully moved rearward within the reservoir 30 and away from the outlet 36 of the reservoir. Although not shown, the remote control device 100 can include another alarm, such as an audible or visual alarm, that the remote processor of the remote control device 100 activates upon receiving the signal from the local processor 50. In addition, the fluid delivery device 10 itself can be provided with an alarm, such as a light emitting diode or electronic buzzer, connected to the local processor 50 for activation when the plunger 44 has been fully moved rearward within the reservoir 30.
  • [0079]
    The pressure level “c” illustrated in the graph is produced upon the third surface 324 of the diaphragm 320 fully expanding into the chamber 328 and closing the third sensor circuit 330 c. Upon receiving signal “c” from the third sensor circuit 330 c, the processor 50 is programmed to send a signal to the remote control device 100 indicating that the flow path 12 is filled and primed. Although not shown, the remote control device 100 can include another alarm, such as an audible or visual alarm, that the remote processor of the remote control device 100 activates upon receiving the signal from the local processor 50. In addition, the fluid delivery device 10 itself can be provided with an alarm, such as a light emitting diode or electronic buzzer, connected to the local processor 50 for activation when the flow path is primed.
  • [0080]
    The preferred volume of the chamber 328 should take into account the compliance of the entire flow path 12 of the device 10. At relative filling pressures, the flow path 12 may expand, thereby artificially adding to the volume of the sensor chamber 328. Any such artificially expanded volume must be taken into account in monitoring the signals received from the sensor. Preferably, the flow path 12 is designed to have minimal compliance at both normal operating pressures and abnormal operating pressures. If minimal compliance of the flow path 12 is not possible, however, the computer algorithm of the processor can be programmed to take the known compliance of the flow path 12 into account when determining flow conditions based upon signals received from the sensor assembly 310.
  • [0081]
    Preferably, the flow path 12 as well as the sensor assembly 310 is constructed from laminated layers of suitably strong and rigid material such as plastic or stainless steel, and can be secured together in a suitable manner, such as with adhesives or by welding. The laminated construction provides many benefits including, but not limited to, simplifying the design and manufacturing of the flow path 12 and the sensor assembly 310, and further reducing the size, complexity and costs of the fluid delivery device 10, so that the device lends itself to being small and disposable in nature.
  • [0082]
    In alternative embodiments, the diaphragm 320 of the flow sensor assembly 310 can be provided as other than a flat layer of resiliently expandable material. The diaphragm can include any structure that provides a fluid-tight barrier between the flow path 12 and the sensor chamber 328, and that moves into the chamber upon an increase in pressure in the flow path 12. For example, the diaphragm may be provided as a piston biased away from the chamber wall with a spring. Many alternative embodiments of the diaphragm are possible while remaining within the scope of the present invention. Examples of flow sensor assemblies are shown in co-pending U.S. patent application Ser. No. 10/087,507, filed on Mar. 1, 2002 (Atty. Docket No. INSL-118), and entitled FLOW CONDITION SENSOR ASSEMBLY FOR PATIENT INFUSION DEVICE, which is assigned to the assignee of the present application and incorporated herein by reference. Moreover, in alternative embodiments of the present invention, the flow sensor assembly can be provided in the form of a simple pressure sensor for determining when the flow path 12 reaches a primed pressure.
  • [0083]
    FIGS. 7 and 8 show another exemplary embodiment of a flow restriction system constructed in accordance with the present invention. The system 400 of FIGS. 7 and 8 is similar to the system 300 of FIG. 5 such that similar elements have the same reference numeral. The flow restriction system 400 of FIGS. 7 and 8, however, further includes a second air removal filter 402 positioned between the fill port 90 and the reservoir 30. The fill port 90 can include a resealing needle insertion septum 92 for receiving a needle and which can be constructed of a resealing elastomer such as silicone that allows a needle to puncture the septum to add fluid to the reservoir 30 through the fill port 90, yet reseals after the needle is withdrawn. Alternatively, the fill port 90 can include a Luer or other connector.
  • [0084]
    The second air removal filter is a flat sheet positioned in the flow path 12 just after the fill port 90, and can be comprised of any material for filtering air from fluid, such as an ultrahigh molecular weight polyethylene in sintered porous form, porous ceramic, hydrophobic gel, a woven or non-woven polytetrafluoroethylene (PTFE) such as Teflon®, woven fabric material having very small openings (e.g., 0.02 microns) such as Goretex®, or hydrophilic material that swells with fluid pressure. The flow path 12 includes an air escape port 404 extending from the filter 402 for allowing filtered air to be directed out of the flow path 12.
  • [0085]
    In the exemplary embodiment of FIGS. 7 and 8, the flow restriction system 400 also includes a second flow restrictor 406 positioned between the second air removal filter 402 and the reservoir 30. The second flow restrictor comprises a narrowed portion 406 of the flow path 12 and elevates pressure within the flow path 12 to ensure that the second air removal filter 402 operates efficiently in removing air from fluid (e.g., insulin) injected into the flow path 12 through the fill port 90.
  • [0086]
    In the exemplary embodiment of FIGS. 7 and 8, the sensor assembly 310 is positioned at the end of the reservoir 30. Positioning the sensor assembly 310 at the end of the reservoir 30 can simplify the manufacturing process of the sensor assembly 310 and the fluid delivery device 10 and can reduce the number of parts to be assembled.
  • [0087]
    FIG. 11 shows another exemplary embodiment of a flow restriction system 420 constructed in accordance with the present invention. The system 420 of FIG. 11 is similar to the system 400 of FIGS. 7 and 8 such that similar elements have the same reference numeral. The flow restriction system 420 of FIG. 11, however, includes a second flow restrictor comprising a porous plug 426 fitted in the flow path 12 to elevate pressure within the flow path 12 and ensure that the second air removal filter 402 operates efficiently in removing air from fluid (e.g., insulin) injected into the flow path through the fill port 90.
  • [0088]
    FIG. 9 shows an exemplary embodiment of an outlet plug 430 constructed in accordance with the present invention. The outlet plug 430 is adapted to be received on a needle 72 of an outlet port assembly 70 of a fluid delivery device. The outlet plug 430 includes a sleeve 432 having a first end removably received in a substantially fluid-tight manner on the distal end of the needle 72, and a cap 434 connected to a second end of the sleeve 432. In the embodiment shown, the sleeve 432 and the cap 434 of the outlet plug 430 are unitarily formed from a resiliently flexible material, such as a synthetic rubber. An air removal filter 436 is seated in the cap 434 of the outlet plug 430 and prevents fluid from passing out of the needle 72 and allows air to pass out of the needle 72. As shown in FIGS. 10 a and 10 b, the air removal filter 436 is provided with predetermined physical properties, such as material pore size and/or thickness, such that the filter 436 expands upon the flow path being substantially primed.
  • [0089]
    The air removal filter 436 can additionally be provided with specific visual indicia for indicating when the flow path is substantially primed. For example, FIGS. 15 a and 15 b, show an exemplary embodiment of the outlet plug 430 wherein the visual indicia comprises a drawing on the filter 436 that changes shape upon the filter expanding. For example, the drawing can comprise two eyes and a mouth that appear as a “sad face” when the filter 436 is not expanded, as shown in FIG. 15 a, and that become a “happy face” upon the filter 436 expanding when the flow path is primed, as shown in FIG. 15 b. Other drawings can alternatively be used to provide an effective indication of filter 436 expansion and the flow path becoming primed.
  • [0090]
    FIGS. 16 a and 16 b show another exemplary embodiment of an outlet plug 440 constructed in accordance with the present invention. The plug 440 of FIGS. 16 a and 16 b is similar to the plug 430 of FIGS. 9, 10 a and 10 b, such that similar elements have the same reference numeral. The outlet plug 440 of FIGS. 16 a and 16 b, however, includes an air removal filter having an outer layer 436 a and an inner layer 436 b. The inner layer 436 b has predetermined physical properties, such as material pore size and/or thickness, that allows the inner layer 436 b to expand to contact the outer layer 436 a upon the flow path becoming substantially primed. The outer layer 436 a of the air removal filter 440 is relatively transparent and the inner layer 436 b is darker in coloring than the outer transparent layer 436 a such that the inner layer 436 b can be seen through the outer layer 436 a when the inner layer contacts the outer layer. Alternatively, the flow restriction system can be provided with a sensor, such as a contact sensor, for providing a signal when the inner layer 436 b contacts the outer layer 436 a.
  • [0091]
    FIG. 12 shows another exemplary embodiment of an outlet plug 450 constructed in accordance with the present invention. The plug 450 of FIG. 12 is similar to the plug 430 of FIGS. 9, 10 a and 10 b, such that similar elements have the same reference numeral. The outlet plug 450 of FIG. 12, however, includes an air removal filter 452 that is comprised of a material that also acts as a needle septum such that the exit port assembly 70 of the fluid delivery device 10 can also act as the fill port for the device 10. For example, FIG. 12 shows the air removal filter 452 receiving a needle 454 of a syringe 456 for filling the flow path of the device 10. The outlet plug 450, therefore, functions as an air removal filter, a flow restrictor and a needle septum. In this manner, the fluid delivery device 10 is further simplified since it does not require a separate fill port.
  • [0092]
    FIG. 13 shows an additional exemplary embodiment of an outlet plug 460 constructed in accordance with the present invention. The plug 460 of FIG. 13 is similar to the plug 430 of FIGS. 9, 10 a and 10 b, such that similar elements have the same reference numeral. The outlet plug 460 of FIG. 13, however, includes a cap 462 further including straps 462 a for securely holding the air removal filter 436 therein.
  • [0093]
    FIG. 14 shows still another exemplary embodiment of an outlet plug 470 constructed in accordance with the present invention. The plug 470 of FIG. 14 is similar to the plug 430 of FIGS. 9, 10 a and 10 b, such that similar elements have the same reference numeral. The outlet plug 470 of FIG. 14, however, further includes a pressure relief valve 472. The relief valve 472 ensures that pressure within the flow path of the fluid delivery device does not become excessive during a filling procedure, i.e., does not exceed a desired maximum level of flow path pressure, which could damage the fluid delivery device. Alternatively, the air removal filter 436 of the outlet plug can be adapted to allow fluid to pass out of the needle 72 upon a pressure within the flow path exceeding a desired maximum level of flow path pressure. The fluid leaking from the needle 72 would then act as a visual indication to a user that the fluid delivery device was improperly filled and should be discarded prior to use.
  • [0094]
    Referring now to FIG. 17, a further exemplary embodiment of an outlet plug 480 constructed in accordance with the present invention is shown. The plug 480 of FIG. 17 may be configured to act only as a flow restrictor (wherein the system would include a separate air removal filter within the flow path of the device 10) or may be configured to act as both the flow restrictor and the air removal filter. In any event, the outlet plug 480 of FIG. 17 also includes a handle 482 for supporting the fluid delivery device 10 during filling of the device through the fill port. The handle 482 of the outlet plug 480 preferably includes an outer contour 484 that nests with an outer contour of an end the fluid delivery device 10, as shown in FIG. 17.
  • [0095]
    FIG. 18 shows another exemplary embodiment of an outlet plug 490 constructed in accordance with the present invention. The outlet plug 490 of FIG. 18 also includes a handle 492 for supporting the fluid delivery device 10 during filling of the device. The handle 492 of the outlet plug 490 includes an outer contour 494 that nests with an outer contour of an end of the fluid delivery device 10. The handle 494 also includes an extension 496 that supports a top surface of the fluid delivery device 10 during filling of the device.
  • [0096]
    An exemplary embodiment of a packaging system 500 constructed in accordance with the present invention is shown in FIG. 19. The packaging system 500 includes a container 502 holding the fluid delivery device 10 (e.g., similar to the fluid delivery device 10 of FIGS. 2 through 4), and a protective cover 504 removably sealing the fluid delivery device 10 within the container 502. The container 502 includes an inner contour 506 that nests with an outer contour of the fluid delivery device 10 to provide support for the device 10 during handling and storage of the package system 500 and during filling of the device 10 by a user. The outlet plug 202 (e.g., similar to the outlet plug of FIGS. 2 through 4) of the flow restriction system is secured to and extends through the protective cover 504, so that the fluid delivery device 10 can be filled while the device 10 is still sealed in the container 502 and the cover 504. In addition, removal of the protective cover 504 from the container 502 removes the outlet plug 202 from the exit port assembly 70. The fluid delivery device 10 also includes a switch mechanism 508, and the protective cover 504 includes an insert 510 extending into the fluid delivery device 10 to normally hold the switch mechanism 508 open. Upon removal of the cover 504, the insert 510 is removed from the switch mechanism 508 such that the switch mechanism 508 can close. The switch mechanism 508 can be used, example, to turn on the processor of the fluid delivery device 10 just prior to the device 10 being attached to a patient.
  • [0097]
    FIGS. 20 a and 20 b show yet a further exemplary embodiment of a flow restriction system 520 and a fluid delivery device 530 constructed in accordance with the present invention. The system 520 and the fluid delivery device 530 of FIGS. 20 a and 20 b are similar to the system 200 and the device 10 of FIGS. 2 through 4 such that similar elements have the same reference numeral.
  • [0098]
    The fluid delivery device 530 of FIGS. 20 and 20 b includes an adhesive layer 22 on a bottom external surface of the housing 20 for securing the device 530 to a patient, and a removable protective layer 26 covering the adhesive layer 22 prior to attachment of the fluid delivery device 530 to a patient. The flow restriction system 520 includes an outlet plug 202 that acts as both a flow restrictor and an air removal filter for the system 520, and is secured to an insertable cannula 72 of the exit port assembly 70 prior to attachment of the fluid delivery device 530 to a patient. The outlet plug 202 is secured to the protective layer 26 of the fluid delivery device 530 so that the plug 202 is also removed from the cannula 72 when the protective layer 26 is removed from the adhesive layer 22 for attachment of the fluid delivery device 530 to a patient. FIG. 20 a shows the protective layer 26 and the outlet plug 202 prior to removal from the fluid delivery device 530, while FIG. 20 b shows the protective layer 26 and the outlet plug 202 after removal from the fluid delivery device 530.
  • [0099]
    The fluid delivery device 530 also includes a switch mechanism 532 for providing an indication when the outlet plug 202 is removed from the distal end of the cannula 72. The switch mechanism 532 can be connected, for example, to the processor (not shown) of the fluid delivery device 530 to provide an indication that the outlet plug 202 has been removed, or can be connected to an alarm, such as an LED, for providing an indication to a user that the outlet plug 202 has been removed. The switch mechanism 532 can also be used to turn on the fluid delivery device 530 (e.g., connect the power source to the processor) upon removal of the outlet plug 202.
  • [0100]
    In the exemplary embodiment shown in FIGS. 20 a and 20 b, the switch mechanism 532 includes a first lead 534 normally biased towards a second lead 536 to close the switch mechanism. The switch mechanism 532 is arranged and oriented with respect to the outlet port assembly 70 such that the outlet plug 202 pushes the first lead 534 away from the second lead 536 when the outlet plug 202 is positioned on the cannula 72, as shown in FIG. 20 a. When the outlet plug 202 is removed from the distal end of the cannula 72, the first lead 534 is allowed to return to the second lead 536 and close the switch mechanism 532, as shown in FIG. 20 b.
  • [0101]
    Additional exemplary embodiments of a flow restriction system 540 and a flow path 550 of a fluid delivery device constructed in accordance with the present invention are shown in FIG. 21. The system 540 and the flow path 550 of FIG. 21 are similar to the system 200 and the flow path 12 of FIGS. 2 through 4 such that similar elements have the same reference numeral. The flow path 550 includes an outlet port assembly comprising a rigid cannula 72 (e.g., a needle with sharpened distal end), a reservoir 30 connected to the cannula 72, and a fill port comprising a needle septum 90 connected to the reservoir 30.
  • [0102]
    The flow restriction system 540 includes an air removal filter 542 positioned in the flow path 550 between the reservoir 30 and the fill port 90, and an outlet plug 544 removably fitted on the sharpened distal end of the rigid cannula 72. The outlet plug 544 is made of a suitable air removal filter material such that the outlet plug 544 functions as both an air removal filter and a flow restrictor. The outlet plug 544 causes an increased pressure within the flow path 550 during filling of the flow path through the fill port 90 (with a needle and syringe, for example), so that air can be effectively filtered through the air removal filter 542 and the outlet plug 544. The outlet plug 544 is removed from the cannula 72 prior to use of the flow path 530 (i.e., prior to injection of the cannula into a patient for delivery of fluid contained in the reservoir).
  • [0103]
    FIG. 22 shows another exemplary embodiment of an outlet plug 560 constructed in accordance with the present invention. The outlet plug 560 is formed as part of a protective layer 562 removably attached to an adhesive layer 22 of the fluid delivery device 10. The exemplary embodiment of the fluid delivery device 10 of FIG. 22 includes an exit port assembly 570 having an injectable needle 572 for insertion into a patient. The needle 572 is extendable out of a port 24 in a housing 20 of the fluid delivery device 10. An o-ring 574 provides a fluid tight seal between the port 24 and the needle 572. The outlet plug 560 provides a substantially fluid-tight seal of the port 24 when the protective layer 562 is attached to the adhesive 22. The outlet plug 560 is made of a suitable air removal filter material such that the outlet plug 560 functions as both an air removal filter and a flow restrictor. In the embodiment shown, the outlet plug 560 is made of a different material than the remainder of the protective layer 562. The remainder of the protective layer 562 is made of a suitable material that readily detaches from the adhesive layer 22, such as wax paper or a plastic. Alternatively, the protective layer can be made entirely of a suitable air removal filter material that is also readily detachable from the adhesive layer 22, such that the portion of the protective layer positioned over the port 24 of the housing 20 can act as the outlet plug.
  • [0104]
    FIGS. 23 and 26 show yet a further exemplary embodiment of a flow restriction system 600 and a fluid delivery device 610 constructed in accordance with the present invention. The system 600 and the fluid delivery device 610 of FIGS. 23 and 26 are similar to the system 200 and the device 10 of FIGS. 2 through 4 such that similar elements have the same reference numeral.
  • [0105]
    A flow path 612 of the fluid delivery device 610 includes a reservoir 630 and an outlet port assembly 670 terminating in a needle 672 for insertion into a patient. The needle 672 is extendable out of a port 624 in a housing 620 of the fluid delivery device 610. An o-ring 674 provides a fluid tight seal between the port 624 and the needle 672. The outlet port assembly 670 also includes an injection mechanism 676 for injecting the needle 672 into a patient. The flow path 612 does not require a separate fill port connected to the reservoir 630, as further discussed below.
  • [0106]
    The flow restriction system 600 includes an air removal filter and a flow restrictor combined in a single outlet plug 602 fitted to the end of the exit port assembly 670, as also shown in FIG. 27. The flow restriction system 600 further includes a flow sensor assembly 330 positioned at the end of the reservoir 630, as also shown in FIG. 24. A second air removal filter 604 is positioned between the reservoir 630 and the exit port assembly 670 and can be adapted to also function as a second flow restrictor if desired.
  • [0107]
    The removable outlet plug 602 is fitted to the end of the exit port assembly 670 and prevents fluid leakage from the flow path 612 prior to use, e.g., during storage and during priming when filled by a user. The outlet plug 602 is removed by a user prior to attaching the fluid delivery device 610 to a patient's skin surface. Also referring to FIG. 25, the outlet plug 602 includes a sleeve 605 having a first end removably received in a substantially fluid-tight manner on the distal end of the needle 672, and a cap 607 connected to a second end of the sleeve 605. In the embodiment shown, the sleeve 605 and the cap 607 of the outlet plug 602 are unitarily formed from a resiliently flexible material. An air removal filter 606 is seated in the cap 607 such that air passing through the filter 606 can exit the outlet plug 602 through an air release port 609 in the cap 607. The air removal filter 606 also acts as the flow restrictor.
  • [0108]
    The outlet plug 602 further includes a needle septum 692. The outlet plug 602, therefore, functions as an air removal filter, a flow restrictor and a needle septum. In this manner, the fluid delivery device 610 is further simplified since it does not require a separate fill port.
  • [0109]
    As illustrated by the above described exemplary embodiments, the present invention generally provides a device for delivering fluid, such as insulin for example, to a patient. The device includes a flow path having an exit port assembly adapted to connect to a transcutaneous patient access tool (e.g., needle), and a reservoir connected to the exit port assembly. The device also includes a flow restriction system having an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly.
  • [0110]
    Among other features and advantages, the flow restriction system of the present invention allows the flow path of the fluid delivery device to be purged of air, or “primed” prior to operation, such that desired volumes of fluid can be accurately delivered by the device.
  • [0111]
    It should be understood that the embodiments described herein are merely exemplary and that a person skilled in the art may make variations and modifications to the embodiments described without departing from the spirit and scope of the present invention. All such equivalent variations and modifications are intended to be included within the scope of this invention as defined by the appended claims.

Claims (21)

  1. 1. A device for delivering fluid to a patient, comprising:
    A) a flow path including,
    an exit port assembly adapted to connect to a transcutaneous patient access tool, and
    a reservoir connected to the exit port assembly; and
    B) a flow restriction system including,
    an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and
    a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly;
    wherein,
    the flow restrictor of the flow restriction system comprises an outlet plug removably connected to the exit port assembly to prevent fluid from exiting the flow path through the exit port assembly;
    the exit port assembly includes a transcutaneous patient access tool comprising a needle having a distal end for insertion into a patient and the outlet plug comprises:
    a sleeve having a first end removably received in a substantially fluid-tight manner on the distal end of the needle; and
    a cap connected to a second end of the sleeve.
  2. 2. A device according to claim 1, wherein the sleeve and the cap of the outlet plug are unitarily formed from a resiliently flexible material.
  3. 3. A device according to claim 1, wherein the air removal filter is seated in the cap of the outlet plug and prevents fluid from passing out of the needle and allows air to pass out of the needle.
  4. 4. A device according to claim 3, wherein the air removal filter of the outlet plug comprises one of PTFE and polyethylene.
  5. 5. A device according to claim 3, wherein the air removal filter of the outlet plug is provided with predetermined physical properties such that the filter expands upon the flow path being substantially primed.
  6. 6. A device according to claim 5, wherein the air removal filter includes visual indicia for indicating when the flow path is substantially primed.
  7. 7. A device according to claim 6, wherein the visual indicia comprises a drawing on the filter that changes shape upon the filter expanding.
  8. 8. A device according to claim 3, wherein the air removal filter of the outlet plug is adapted to allow fluid to pass out of the needle upon a pressure within the flow path exceeding a desired maximum level of flow path pressure.
  9. 9. A device according to claim 3, wherein the air removal filter of the outlet plug includes:
    an outer layer; and
    an inner layer having predetermined physical properties that allow the inner layer to expand to contact the outer layer upon the flow path being substantially primed.
  10. 10. A device according to claim 9, wherein the outer layer of the air removal filter is relatively transparent and the inner layer of the air removal filter is darker in coloring than the outer transparent layer such that the inner layer can be seen through the outer layer when the inner layer contacts the outer layer.
  11. 11. A device according to claim 9, wherein the flow restriction system further includes a filter sensor for providing a signal when the inner layer contacts the outer layer.
  12. 12. A device according to claim 3, wherein the air bubble removal filter of the outlet plug is comprised of needle septum material.
  13. 13. A device for delivering fluid to a patient, comprising:
    A) a flow path including,
    an exit port assembly adapted to connect to a transcutaneous patient access tool, and
    a reservoir connected to the exit port assembly; and
    B) a flow restriction system including,
    an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and
    a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly;
    wherein,
    the flow restrictor of the flow restriction system comprises an outlet plug removably connected to the exit port assembly to prevent fluid from exiting the flow path through the exit port assembly; and
    the outlet plug further comprises a needle septum.
  14. 14. A device for delivering fluid to a patient, comprising:
    A) a flow path including,
    an exit port assembly adapted to connect to a transcutaneous patient access tool, and
    a reservoir connected to the exit port assembly; and
    B) a flow restriction system including,
    an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and
    a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly;
    wherein,
    the flow restrictor of the flow restriction system comprises an outlet plug removably connected to the exit port assembly to prevent fluid from exiting the flow path through the exit port assembly; and
    the outlet plug includes a pressure relief valve actuable upon a pressure within the flow path exceeding a desired maximum level of flow path pressure.
  15. 15. A device for delivering fluid to a patient, comprising:
    A) a flow path including,
    an exit port assembly adapted to connect to a transcutaneous patient access tool, and
    a reservoir connected to the exit port assembly; and
    B) a flow restriction system including,
    an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and
    a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly;
    wherein,
    the flow restrictor of the flow restriction system comprises an outlet plug removably connected to the exit port assembly to prevent fluid from exiting the flow path through the exit port assembly; and
    further comprising:
    a housing containing the flow path, wherein the exit port assembly extends at least partly through a port in the housing;
    an adhesive layer provided in at least one continuous band on an exterior surface of the housing surrounding the port of the housing; and
    a protective layer removably covering the adhesive layer, wherein the outlet plug of the flow restriction system is secured to the protective layer so that removal of the protective layer removes the outlet plug from the exit port assembly.
  16. 16. A device for delivering fluid to a patient, comprising:
    A) a flow path including,
    an exit port assembly adapted to connect to a transcutaneous patient access tool, and
    a reservoir connected to the exit port assembly; and
    B) a flow restriction system including,
    an air removal filter communicating with the flow path and allowing air to exit the flow path and preventing fluid from exiting the flow path, and
    a flow restrictor positioned within the flow path between the air removal filter and the exit port assembly;
    wherein,
    the flow restrictor of the flow restriction system comprises an outlet plug removably connected to the exit port assembly to prevent fluid from exiting the flow path through the exit port assembly; and
    further comprising a switch arranged to be closed upon removal of the outlet plug from the exit port assembly.
  17. 17. A device according to claim 16, wherein the outlet plug includes a handle for supporting the fluid delivery device during filling of the device through the fill port.
  18. 18. A device according to claim 17, wherein the handle of the outlet plug includes an outer contour that nests with an outer contour of the fluid delivery device.
  19. 19. A packaging system including a device according to claim 16, and further including:
    a container holding the fluid delivery device; and
    a protective cover removably sealing the fluid delivery device within the container, wherein the outlet plug of the flow restriction system is secured to the protective cover so that removal of the protective cover from the container removes the outlet plug from the exit port assembly.
  20. 20. The packaging system of claim 19, wherein the container includes an inner contour that nests with an outer contour of the fluid delivery device.
  21. 21. The packaging system of claim 19, wherein the fluid delivery device includes a switch and the protective cover includes an insert extending into the fluid delivery device to normally hold the switch open.
US11163234 2002-07-16 2005-10-11 Flow restriction system and method for patient infusion device Abandoned US20060041229A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10198690 US7018360B2 (en) 2002-07-16 2002-07-16 Flow restriction system and method for patient infusion device
US11163234 US20060041229A1 (en) 2002-07-16 2005-10-11 Flow restriction system and method for patient infusion device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11163234 US20060041229A1 (en) 2002-07-16 2005-10-11 Flow restriction system and method for patient infusion device

Publications (1)

Publication Number Publication Date
US20060041229A1 true true US20060041229A1 (en) 2006-02-23

Family

ID=30115165

Family Applications (2)

Application Number Title Priority Date Filing Date
US10198690 Expired - Fee Related US7018360B2 (en) 2002-07-16 2002-07-16 Flow restriction system and method for patient infusion device
US11163234 Abandoned US20060041229A1 (en) 2002-07-16 2005-10-11 Flow restriction system and method for patient infusion device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10198690 Expired - Fee Related US7018360B2 (en) 2002-07-16 2002-07-16 Flow restriction system and method for patient infusion device

Country Status (2)

Country Link
US (2) US7018360B2 (en)
WO (1) WO2004006981A3 (en)

Cited By (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050160858A1 (en) * 2002-07-24 2005-07-28 M 2 Medical A/S Shape memory alloy actuator
US20050192561A1 (en) * 2002-07-24 2005-09-01 M 2 Medical A/S Infusion pump system, an infusion pump unit and an infusion pump
US20050245878A1 (en) * 2002-11-05 2005-11-03 M 2 Medical A/S Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US20050251097A1 (en) * 2002-12-23 2005-11-10 M 2 Medical A/S Flexible piston rod
US20050273059A1 (en) * 2002-12-23 2005-12-08 M 2 Medical A/S Disposable, wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US20070049870A1 (en) * 2001-05-18 2007-03-01 Deka Products Limited Partnership Infusion Set for a Fluid Pump
US20070073235A1 (en) * 2005-09-26 2007-03-29 Estes Mark C Operating an infusion pump system
US20070073236A1 (en) * 2005-09-26 2007-03-29 Morten Mernoe Dispensing fluid from an infusion pump system
US20070073228A1 (en) * 2005-09-26 2007-03-29 Morten Mernoe Dispensing fluid from an infusion pump system
US20070124002A1 (en) * 2005-11-08 2007-05-31 M2 Medical A/S Method and System for Manual and Autonomous Control of an Infusion Pump
US20070123819A1 (en) * 2005-11-08 2007-05-31 M2 Medical A/S Infusion Pump System
US20070167912A1 (en) * 2005-09-26 2007-07-19 M2 Medical A/S Operating an Infusion Pump System
US20070185449A1 (en) * 2005-04-06 2007-08-09 Morten Mernoe Actuator with string drive #1
US20070213657A1 (en) * 2006-02-28 2007-09-13 Abbott Diabetes Care, Inc Smart messages and alerts for an infusion delivery and management system
US20070219480A1 (en) * 2006-02-09 2007-09-20 Dean Kamen Patch-sized fluid delivery systems and methods
US20080004515A1 (en) * 2006-06-30 2008-01-03 Abbott Diabetes Care, Inc. Integrated Analyte Sensor and Infusion Device and Methods Therefor
US20080086086A1 (en) * 2006-10-10 2008-04-10 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US20080102119A1 (en) * 2006-11-01 2008-05-01 Medtronic, Inc. Osmotic pump apparatus and associated methods
US20080161754A1 (en) * 2006-12-29 2008-07-03 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US20080294108A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Infusion Pump System with Contamination-Resistant Features
US20080294109A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Illumination Instrument for an Infusion Pump
US20080294094A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Occlusion Sensing for an Infusion Pump
US20080294142A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Removable Controller for an Infusion Pump
US20090002179A1 (en) * 2007-06-28 2009-01-01 Abbott Diabetes Care, Inc. Signal converting cradle for medical condition monitoring and management system
US20090012377A1 (en) * 2007-06-27 2009-01-08 Abbott Diabetes Care, Inc. Method and structure for securing a monitoring device element
US20090048501A1 (en) * 2003-07-15 2009-02-19 Therasense, Inc. Glucose measuring device integrated into a holster for a personal area network device
US20090054745A1 (en) * 2006-08-07 2009-02-26 Abbott Diabetes Care, Inc. Method and System for Providing Data Management in Integrated Analyte Monitoring and Infusion System
US20090054750A1 (en) * 2006-08-07 2009-02-26 Abbott Diabetes Care, Inc. Method and System for Providing Integrated Analyte Monitoring and Infusion System Therapy Management
US20090069787A1 (en) * 2007-09-07 2009-03-12 M2 Medical Activity Sensing Techniques for an Infusion Pump System
US20090067989A1 (en) * 2007-09-06 2009-03-12 M2 Medical Group Holdings, Inc. Occlusion Sensing System for Infusion Pumps
US20090069746A1 (en) * 2007-09-07 2009-03-12 M2 Medical Group Holdings, Inc. Data Storage for an Infusion Pump System
US20090099523A1 (en) * 2001-05-18 2009-04-16 Grant Kevin L Infusion pump assembly
US20090156990A1 (en) * 2007-12-12 2009-06-18 M2 Medical Group Holdings, Inc. Portable Infusion Pump and Media Player
US20090171269A1 (en) * 2006-06-29 2009-07-02 Abbott Diabetes Care, Inc. Infusion Device and Methods Therefor
US20090281497A1 (en) * 2007-12-31 2009-11-12 Dean Kamen Wearable pump assembly
US20100008794A1 (en) * 2002-10-09 2010-01-14 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US20100089475A1 (en) * 2008-10-10 2010-04-15 Tracey Brian D Medium connector
US20100094222A1 (en) * 2008-10-10 2010-04-15 Grant Kevin L Infusion pump assembly
US20100094215A1 (en) * 2008-10-10 2010-04-15 Grant Kevin L Pump assembly with a removable cover assembly
US7717903B2 (en) 2007-09-06 2010-05-18 M2 Group Holdings, Inc. Operating an infusion pump system
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US7753879B2 (en) 2004-01-29 2010-07-13 M2 Group Holdings, Inc. Disposable medicine dispensing device
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US20100274108A1 (en) * 2005-09-30 2010-10-28 Abbott Diabetes Care Inc. Method and Apparatus for Providing Rechargeable Power in Data Monitoring and Management Systems
US20100331826A1 (en) * 2008-01-28 2010-12-30 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
US20110022025A1 (en) * 2009-07-23 2011-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US7879026B2 (en) 2007-09-07 2011-02-01 Asante Solutions, Inc. Controlled adjustment of medicine dispensation from an infusion pump device
US20110040252A1 (en) * 2007-10-16 2011-02-17 Peter Gravesen Cannula Insertion Device and Related Methods
US20110043357A1 (en) * 2009-08-18 2011-02-24 Greg Peatfield Methods for detecting failure states in a medicine delivery device
US20110046558A1 (en) * 2009-08-18 2011-02-24 Peter Gravesen Medicine delivery device having detachable pressure sensing unit
US20110054285A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Flexible and Conformal Patch Pump
US20110054390A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Extended Use Medical Device
US7922458B2 (en) 2002-10-09 2011-04-12 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US8029460B2 (en) 2005-03-21 2011-10-04 Abbott Diabetes Care Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US8047811B2 (en) 2002-10-09 2011-11-01 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US8057436B2 (en) 2005-09-26 2011-11-15 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US8112138B2 (en) 2005-06-03 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US8115635B2 (en) 2005-02-08 2012-02-14 Abbott Diabetes Care Inc. RF tag on test strips, test strip vials and boxes
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US8287514B2 (en) 2007-09-07 2012-10-16 Asante Solutions, Inc. Power management techniques for an infusion pump system
US8287495B2 (en) 2009-07-30 2012-10-16 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8454557B1 (en) 2012-07-19 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US8454581B2 (en) 2011-03-16 2013-06-04 Asante Solutions, Inc. Infusion pump systems and methods
US8454562B1 (en) 2012-07-20 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
US8512246B2 (en) 2003-04-28 2013-08-20 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
USD691258S1 (en) 2010-05-27 2013-10-08 Asante Solutions, Inc. Infusion pump
US8551046B2 (en) 2006-09-18 2013-10-08 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US8573027B2 (en) 2009-02-27 2013-11-05 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
US8585657B2 (en) 2011-06-21 2013-11-19 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8638220B2 (en) 2005-10-31 2014-01-28 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8798934B2 (en) 2009-07-23 2014-08-05 Abbott Diabetes Care Inc. Real time management of data relating to physiological control of glucose levels
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US8808230B2 (en) 2011-09-07 2014-08-19 Asante Solutions, Inc. Occlusion detection for an infusion pump system
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US9427523B2 (en) 2012-12-10 2016-08-30 Bigfoot Biomedical, Inc. Infusion pump system and method
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9446187B2 (en) 2013-06-03 2016-09-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US9623173B2 (en) 2012-03-05 2017-04-18 Becton, Dickinson And Company Wireless communication for on-body medical devices
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US9750444B2 (en) 2009-09-30 2017-09-05 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US9782536B2 (en) 2009-01-12 2017-10-10 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
USD809134S1 (en) 2016-03-10 2018-01-30 Bigfoot Biomedical, Inc. Infusion pump assembly
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9968747B2 (en) 2007-10-16 2018-05-15 Cequr Sa Cannula insertion device and related methods

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682521B2 (en) 2000-03-23 2004-01-27 Dennis N. Petrakis Temperature activated systems
US7607402B2 (en) 2001-03-23 2009-10-27 Petrakis Dennis N Temperature responsive systems
US7445616B2 (en) * 2001-03-23 2008-11-04 Petrakis Dennis N Temperature responsive systems
US7655001B2 (en) 2001-03-23 2010-02-02 Petrakis Dennis N Temperature responsive systems
US7476224B2 (en) * 2003-03-17 2009-01-13 Petrakis Dennis N Temperature responsive systems
CA2739968A1 (en) 2008-10-10 2010-04-15 Deka Products Limited Partnership Infusion pump assembly
US8728024B2 (en) 2008-10-10 2014-05-20 Deka Products Limited Partnership Infusion pump methods, systems and apparatus
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
US7066029B2 (en) 2003-09-25 2006-06-27 Deka Products Limited Partnership System and method for improved volume measurement
US20060166629A1 (en) * 2005-01-24 2006-07-27 Therasense, Inc. Method and apparatus for providing EMC Class-B compliant RF transmitter for data monitoring an detection systems
US7686787B2 (en) 2005-05-06 2010-03-30 Medtronic Minimed, Inc. Infusion device and method with disposable portion
EP1881820A4 (en) * 2005-05-17 2014-11-12 Roche Diagnostics Gmbh Disposable dispenser for patient infusion
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US20080004601A1 (en) * 2006-06-28 2008-01-03 Abbott Diabetes Care, Inc. Analyte Monitoring and Therapy Management System and Methods Therefor
US7455663B2 (en) * 2006-08-23 2008-11-25 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US20080051765A1 (en) * 2006-08-23 2008-02-28 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8277415B2 (en) * 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US8512288B2 (en) * 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7905868B2 (en) * 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US7811262B2 (en) * 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8352041B2 (en) 2006-11-28 2013-01-08 The Alfred E. Mann Foundation For Scientific Research Remote controls and ambulatory medical systems including the same
US8352042B2 (en) * 2006-11-28 2013-01-08 The Alfred E. Mann Foundation For Scientific Research Remote controls and ambulatory medical systems including the same
JP4886535B2 (en) 2007-01-30 2012-02-29 日本コヴィディエン株式会社 Cap for the connector
CA2677667A1 (en) * 2007-02-09 2008-08-14 Deka Products Limited Partnership Automated insertion assembly
US9636450B2 (en) * 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8323250B2 (en) * 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8434528B2 (en) * 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US7959715B2 (en) * 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
JP5102350B2 (en) 2007-04-30 2012-12-19 メドトロニック ミニメド インコーポレイテッド A method using a reservoir filling / bubble management / infusion medium delivery system and the system
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US20090063402A1 (en) * 2007-08-31 2009-03-05 Abbott Diabetes Care, Inc. Method and System for Providing Medication Level Determination
US20090164251A1 (en) * 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Method and apparatus for providing treatment profile management
US20090164239A1 (en) * 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
CN103127573B (en) 2008-04-09 2015-03-25 F·霍夫曼-拉罗氏股份公司 Module skin-adherable system for medical fluid delivery
WO2010009172A1 (en) 2008-07-14 2010-01-21 Abbott Diabetes Care Inc. Closed loop control system interface and methods
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US9943644B2 (en) * 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100057040A1 (en) * 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US8622988B2 (en) * 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
CA2954728A1 (en) 2008-09-15 2010-03-18 Deka Products Limited Partnership Systems and methods for fluid delivery
US20100198196A1 (en) * 2009-01-30 2010-08-05 Abbott Diabetes Care, Inc. Therapy Delivery Device Programming Tool
WO2011008966A3 (en) 2009-07-15 2011-08-11 Deka Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
US8478557B2 (en) * 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
US8998858B2 (en) * 2009-12-29 2015-04-07 Medtronic Minimed, Inc. Alignment and connection systems and methods
US8882710B2 (en) * 2009-09-02 2014-11-11 Medtronic Minimed, Inc. Insertion device systems and methods
US8900190B2 (en) * 2009-09-02 2014-12-02 Medtronic Minimed, Inc. Insertion device systems and methods
US9039653B2 (en) * 2009-12-29 2015-05-26 Medtronic Minimed, Inc. Retention systems and methods
USD810278S1 (en) 2009-09-15 2018-02-13 Medimop Medical Projects Ltd. Injector device
US8157769B2 (en) * 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US20120215163A1 (en) 2009-12-30 2012-08-23 Medtronic Minimed, Inc. Sensing systems and methods
US8308679B2 (en) * 2009-12-30 2012-11-13 Medtronic Minimed, Inc. Alignment systems and methods
US8998840B2 (en) 2009-12-30 2015-04-07 Medtronic Minimed, Inc. Connection and alignment systems and methods
US8858500B2 (en) 2009-12-30 2014-10-14 Medtronic Minimed, Inc. Engagement and sensing systems and methods
US9421321B2 (en) * 2009-12-30 2016-08-23 Medtronic Minimed, Inc. Connection and alignment systems and methods
US8435209B2 (en) * 2009-12-30 2013-05-07 Medtronic Minimed, Inc. Connection and alignment detection systems and methods
US9662438B2 (en) 2010-02-05 2017-05-30 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
JP5869554B2 (en) * 2010-03-30 2016-02-24 デカ・プロダクツ・リミテッド・パートナーシップ The method of infusion pump systems and devices
CN103025369B (en) 2010-06-07 2016-07-06 安姆根有限公司 A drug delivery device
US8814829B2 (en) 2010-08-12 2014-08-26 Baxter International Inc. Drug delivery device for fluid restricted patients
WO2013149186A1 (en) 2012-03-30 2013-10-03 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechansim and blood glucose monitoring for use therewith
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US20140128815A1 (en) 2012-11-02 2014-05-08 Medimop Medical Projects Ltd. Adhesive structure for medical device
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
US20160144108A1 (en) * 2014-11-26 2016-05-26 Medtronic Minimed, Inc. Systems and methods for fluid infusion device with automatic reservoir fill
US20160175544A1 (en) * 2014-12-18 2016-06-23 Marc Andrew Koska Single use injection system

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631847A (en) * 1966-03-04 1972-01-04 James C Hobbs Method and apparatus for injecting fluid into the vascular system
US3812843A (en) * 1973-03-12 1974-05-28 Lear Siegler Inc Method and apparatus for injecting contrast media into the vascular system
US4067000A (en) * 1976-05-28 1978-01-03 Rca Corporation Remote control transmitter with an audible battery life indicator
US4108177A (en) * 1976-04-23 1978-08-22 Michel Louis Paul Pistor Automatic injector device
US4151845A (en) * 1977-11-25 1979-05-01 Miles Laboratories, Inc. Blood glucose control apparatus
US4193397A (en) * 1977-12-01 1980-03-18 Metal Bellows Corporation Infusion apparatus and method
US4211998A (en) * 1977-08-25 1980-07-08 Stierlen-Maquet Aktiengesellschaft Method of and remote control apparatus for remotely controlling a medical appliance
US4268150A (en) * 1980-01-28 1981-05-19 Laurence Chen Disposable camera with simplified film advance and indicator
US4342311A (en) * 1979-01-08 1982-08-03 Whitney Douglass G Injector with programming means
US4373527A (en) * 1979-04-27 1983-02-15 The Johns Hopkins University Implantable, programmable medication infusion system
US4424720A (en) * 1980-12-15 1984-01-10 Ivac Corporation Mechanism for screw drive and syringe plunger engagement/disengagement
US4435173A (en) * 1982-03-05 1984-03-06 Delta Medical Industries Variable rate syringe pump for insulin delivery
US4498843A (en) * 1982-08-02 1985-02-12 Schneider Philip H Insulin infusion pump
US4507115A (en) * 1981-04-01 1985-03-26 Olympus Optical Co., Ltd. Medical capsule device
US4514732A (en) * 1982-08-23 1985-04-30 General Electric Company Technique for increasing battery life in remote control transmitters
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4562751A (en) * 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4585439A (en) * 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
US4601707A (en) * 1980-06-03 1986-07-22 Albisser Anthony M Insulin infusion device
US4634427A (en) * 1984-09-04 1987-01-06 American Hospital Supply Company Implantable demand medication delivery assembly
US4678408A (en) * 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4684368A (en) * 1984-06-01 1987-08-04 Parker Hannifin Corporation Inverted pump
US4685903A (en) * 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4734092A (en) * 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US4801857A (en) * 1986-08-27 1989-01-31 Sundstrand Corporation Servo loop control system with dynamic limiting
US4808161A (en) * 1986-03-04 1989-02-28 Kamen Dean L Pressure-measurement flow control system
US4836752A (en) * 1987-11-02 1989-06-06 Fisher Scientific Company Partial restriction detector
US4898578A (en) * 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
US4898579A (en) * 1987-06-26 1990-02-06 Pump Controller Corporation Infusion pump
USD306691S (en) * 1986-05-23 1990-03-20 Fuji Photo Film Co., Ltd. Disposable camera
US4944659A (en) * 1987-01-27 1990-07-31 Kabivitrum Ab Implantable piezoelectric pump system
US5007458A (en) * 1990-04-23 1991-04-16 Parker Hannifin Corporation Poppet diaphragm valve
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
US5125412A (en) * 1990-07-23 1992-06-30 Thornton William E Musculoskeletal activity monitor
US5176662A (en) * 1990-08-23 1993-01-05 Minimed Technologies, Ltd. Subcutaneous injection set with improved cannula mounting arrangement
US5178609A (en) * 1990-06-19 1993-01-12 Kato Hatsujo Kaisha, Ltd. Medical liquid injector for continuous transfusion
US5189609A (en) * 1987-10-09 1993-02-23 Hewlett-Packard Company Medical monitoring system with softkey control
US5205819A (en) * 1989-05-11 1993-04-27 Bespak Plc Pump apparatus for biomedical use
US5213483A (en) * 1991-06-19 1993-05-25 Strato Medical Corporation Peristaltic infusion pump with removable cassette and mechanically keyed tube set
US5281202A (en) * 1991-09-03 1994-01-25 Fresenius Ag Device for draining a flexible fluid container
US5308335A (en) * 1991-06-25 1994-05-03 Medication Delivery Devices Infusion pump, treatment fluid bag therefor, and method for the use thereof
US5312337A (en) * 1990-10-10 1994-05-17 Strato Medical Corporation Catheter attachment device
US5318540A (en) * 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5385662A (en) * 1991-11-27 1995-01-31 Electro Chemical Engineering Gmbh Method of producing oxide ceramic layers on barrier layer-forming metals and articles produced by the method
US5411480A (en) * 1989-06-16 1995-05-02 Science Incorporated Fluid delivery apparatus
US5426404A (en) * 1994-01-28 1995-06-20 Motorola, Inc. Electrical circuit using low volume multilayer transmission line devices
US5433710A (en) * 1993-03-16 1995-07-18 Minimed, Inc. Medication infusion pump with fluoropolymer valve seat
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5505709A (en) * 1994-09-15 1996-04-09 Minimed, Inc., A Delaware Corporation Mated infusion pump and syringe
US5507288A (en) * 1994-05-05 1996-04-16 Boehringer Mannheim Gmbh Analytical system for monitoring a substance to be analyzed in patient-blood
US5514096A (en) * 1993-12-28 1996-05-07 Nissho Corporation Apparatus and balloon for dosing a liquid medicine
US5533389A (en) * 1986-03-04 1996-07-09 Deka Products Limited Partnership Method and system for measuring volume and controlling flow
US5630710A (en) * 1994-03-09 1997-05-20 Baxter International Inc. Ambulatory infusion pump
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
US5647853A (en) * 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
US5704520A (en) * 1993-07-19 1998-01-06 Elan Medical Technologies, Limited Liquid material dispenser and valve
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
US5741228A (en) * 1995-02-17 1998-04-21 Strato/Infusaid Implantable access device
US5748827A (en) * 1996-10-23 1998-05-05 University Of Washington Two-stage kinematic mount
US5747350A (en) * 1993-04-02 1998-05-05 Boehringer Mannheim Gmbh System for dosing liquids
US5755682A (en) * 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US5764159A (en) * 1994-02-16 1998-06-09 Debiotech S.A. Apparatus for remotely monitoring controllable devices
US5776103A (en) * 1995-10-11 1998-07-07 Science Incorporated Fluid delivery device with bolus injection site
US5779696A (en) * 1990-07-23 1998-07-14 Sunrise Technologies International, Inc. Method and apparatus for performing corneal reshaping to correct ocular refractive errors
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US5785681A (en) * 1997-02-25 1998-07-28 Minimed Inc. Flow rate controller for a medication infusion pump
US5858239A (en) * 1997-02-14 1999-01-12 Aksys, Ltd. Methods and apparatus for adjustment of blood drip chamber of dialysis machines using touchscreen interface
US5858005A (en) * 1997-08-27 1999-01-12 Science Incorporated Subcutaneous infusion set with dynamic needle
US5865806A (en) * 1996-04-04 1999-02-02 Becton Dickinson And Company One step catheter advancement automatic needle retraction system
US5871470A (en) * 1997-04-18 1999-02-16 Becton Dickinson And Company Combined spinal epidural needle set
US5875393A (en) * 1997-02-28 1999-02-23 Randice-Lisa Altschul Disposable wireless telephone and method
US5886647A (en) * 1996-12-20 1999-03-23 Badger; Berkley C. Apparatus and method for wireless, remote control of multiple devices
US5891097A (en) * 1994-08-12 1999-04-06 Japan Storage Battery Co., Ltd. Electrochemical fluid delivery device
US5897530A (en) * 1997-12-24 1999-04-27 Baxter International Inc. Enclosed ambulatory pump
US5906597A (en) * 1998-06-09 1999-05-25 I-Flow Corporation Patient-controlled drug administration device
US5919167A (en) * 1998-04-08 1999-07-06 Ferring Pharmaceuticals Disposable micropump
US6019747A (en) * 1997-10-21 2000-02-01 I-Flow Corporation Spring-actuated infusion syringe
US6024539A (en) * 1992-09-09 2000-02-15 Sims Deltec, Inc. Systems and methods for communicating with ambulatory medical devices such as drug delivery devices
US6061580A (en) * 1997-02-28 2000-05-09 Randice-Lisa Altschul Disposable wireless telephone and method for call-out only
US6071292A (en) * 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US6174300B1 (en) * 1997-08-27 2001-01-16 Science Incorporated Fluid delivery device with temperature controlled energy source
US6190359B1 (en) * 1996-04-30 2001-02-20 Medtronic, Inc. Method and apparatus for drug infusion
US6206850B1 (en) * 1996-03-14 2001-03-27 Christine O'Neil Patient controllable drug delivery system flow regulating means
US6244776B1 (en) * 1998-01-05 2001-06-12 Lien J. Wiley Applicators for health and beauty products
US6363609B1 (en) * 2000-10-20 2002-04-02 Short Block Technologies, Inc. Method and apparatus for aligning crankshaft sections
US6375638B2 (en) * 1999-02-12 2002-04-23 Medtronic Minimed, Inc. Incremental motion pump mechanisms powered by shape memory alloy wire or the like
US6427088B1 (en) * 2000-01-21 2002-07-30 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using telemetry system with predefined reception listening periods
US6520936B1 (en) * 1999-06-08 2003-02-18 Medtronic Minimed, Inc. Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
US6527744B1 (en) * 1997-08-27 2003-03-04 Science Incorporated Fluid delivery device with light activated energy source
US6572585B2 (en) * 2001-07-12 2003-06-03 Soo Bong Choi Remote-controlled portable automatic syringe device
US6585707B2 (en) * 1998-05-21 2003-07-01 Elan Pharma International Limited Drug delivery device having improved adhesion and attachment system for drug delivery device
US6692457B2 (en) * 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6706159B2 (en) * 2000-03-02 2004-03-16 Diabetes Diagnostics Combined lancet and electrochemical analyte-testing apparatus
US20040068224A1 (en) * 2002-10-02 2004-04-08 Couvillon Lucien Alfred Electroactive polymer actuated medication infusion pumps
US6723072B2 (en) * 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
US6740059B2 (en) * 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885662A (en) 1973-12-26 1975-05-27 Ibm Steerable follower selection mechanism
DE2738155C2 (en) 1977-08-24 1987-08-20 Stierlen-Maquet Ag, 7550 Rastatt, De
US4559037A (en) 1977-12-28 1985-12-17 Siemens Aktiengesellschaft Device for the pre-programmable infusion of liquids
US4475901A (en) 1980-07-23 1984-10-09 The Garvan Research Development Ltd. Apparatus for improving blood sugar control in diabetics
US4559033A (en) 1980-10-27 1985-12-17 University Of Utah Research Foundation Apparatus and methods for minimizing peritoneal injection catheter obstruction
US4364385A (en) 1981-03-13 1982-12-21 Lossef Steven V Insulin delivery device
JPS6149981B2 (en) 1981-06-23 1986-10-31 Terumo Corp
US4551134A (en) 1982-08-06 1985-11-05 Nuvatec, Inc. Intravenous set
US4624661A (en) * 1982-11-16 1986-11-25 Surgidev Corp. Drug dispensing system
DE3314664C2 (en) 1983-04-22 1985-02-21 B. Braun Melsungen Ag, 3508 Melsungen, De
US4781693A (en) 1983-09-02 1988-11-01 Minntech Corporation Insulin dispenser for peritoneal cavity
US4743243A (en) * 1984-01-03 1988-05-10 Vaillancourt Vincent L Needle with vent filter assembly
US4855746A (en) 1984-07-30 1989-08-08 Zenith Electronics Corporation Multiple device remote control transmitter
CA1254091A (en) * 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4755173A (en) * 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
DE3771112D1 (en) 1986-04-04 1991-08-08 Thoma Dipl Ing Dr Techn Herwig Device for stroemungskonstanten delivery of liquid medicines.
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
DE3882202D1 (en) 1987-05-18 1993-08-12 Disetronic Ag Infusionsgeraet.
JPH021276A (en) * 1987-10-30 1990-01-05 Issei Suzuki Plug device of drip bottle
US4801957A (en) * 1988-02-18 1989-01-31 Eastman Kodak Company Disposable single-use camera and accessory re-usable electronic flash unit
US5062841A (en) 1988-08-12 1991-11-05 The Regents Of The University Of California Implantable, self-regulating mechanochemical insulin pump
US4882600A (en) * 1989-04-07 1989-11-21 Eastman Kodak Company Underwater disposable single-use camera
US5045871A (en) * 1989-06-30 1991-09-03 Reinholdson Mark R Disposable camera
US4973998A (en) * 1990-01-16 1990-11-27 Eastman Kodak Company Disposable single-use camera and accessory re-usable electronic flash unit
US5125415A (en) * 1990-06-19 1992-06-30 Smiths Industries Medical Systems, Inc. Syringe tip cap with self-sealing filter
US5242406A (en) 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
US5848991A (en) * 1990-12-13 1998-12-15 Elan Medical Technologies Limited Athlone, Co. Intradermal drug delivery device and method for intradermal delivery of drugs
US5245447A (en) 1991-05-20 1993-09-14 Xerox Corporation Indexing mechanism for compact scanner
US5239326A (en) * 1991-08-07 1993-08-24 Kabushiki Kaisha Senshukai Film-loaded disposable camera
US5244463A (en) * 1991-12-06 1993-09-14 Block Medical, Inc. Programmable infusion pump
US5911716A (en) * 1992-01-24 1999-06-15 I-Flow Corporation Platen pump
US5267956A (en) 1992-02-05 1993-12-07 Alcon Surgical, Inc. Surgical cassette
US5346476A (en) * 1992-04-29 1994-09-13 Edward E. Elson Fluid delivery system
US5935099A (en) * 1992-09-09 1999-08-10 Sims Deltec, Inc. Drug pump systems and methods
US5254096A (en) 1992-09-23 1993-10-19 Becton, Dickinson And Company Syringe pump with graphical display or error conditions
US5232439A (en) * 1992-11-02 1993-08-03 Infusion Technologies Corporation Method for pumping fluid from a flexible, variable geometry reservoir
US5342313A (en) * 1992-11-02 1994-08-30 Infusion Technologies Corporation Fluid pump for a flexible, variable geometry reservoir
US5257980A (en) 1993-04-05 1993-11-02 Minimed Technologies, Ltd. Subcutaneous injection set with crimp-free soft cannula
EP0722541B1 (en) * 1993-10-04 1998-12-30 Research International, Inc. Micromachined flow switches
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5643213A (en) 1994-03-09 1997-07-01 I-Flow Corporation Elastomeric syringe actuation device
US5576781A (en) * 1994-05-16 1996-11-19 Deleeuw; Paul Disposable camera
US5452033A (en) * 1994-06-06 1995-09-19 Eastman Kodak Company Single use photographic film package and camera
US5582593A (en) 1994-07-21 1996-12-10 Hultman; Barry W. Ambulatory medication delivery system
US5545152A (en) 1994-10-28 1996-08-13 Minimed Inc. Quick-connect coupling for a medication infusion system
US5665070A (en) * 1995-01-19 1997-09-09 I-Flow Corporation Infusion pump with magnetic bag compression
US5575770A (en) * 1995-04-05 1996-11-19 Therex Corporation Implantable drug infusion system with safe bolus capability
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
US5695490A (en) * 1995-06-07 1997-12-09 Strato/Infusaid, Inc. Implantable treatment material device
US5584813A (en) * 1995-06-07 1996-12-17 Minimed Inc. Subcutaneous injection set
US5702363A (en) * 1995-06-07 1997-12-30 Flaherty; J. Christopher Septumless implantable treatment material device
US5810015A (en) * 1995-09-01 1998-09-22 Strato/Infusaid, Inc. Power supply for implantable device
US5814020A (en) * 1995-09-11 1998-09-29 Elan Medical Technlogies Limited Medicament delivery device
US5779676A (en) * 1995-10-11 1998-07-14 Science Incorporated Fluid delivery device with bolus injection site
US5800405A (en) * 1995-12-01 1998-09-01 I-Flow Corporation Syringe actuation device
US5830187A (en) * 1995-12-22 1998-11-03 Science Incorporated Fluid delivery device with conformable ullage and fill assembly
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US5797881A (en) * 1996-06-20 1998-08-25 Gadot; Amir Intravenous infusion apparatus
US5851197A (en) * 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
US5845218A (en) * 1997-02-28 1998-12-01 Altschul; Randice-Lisa Disposable wireless telephone and method
US5957890A (en) * 1997-06-09 1999-09-28 Minimed Inc. Constant flow medication infusion pump
US5965848A (en) * 1997-07-22 1999-10-12 Randice-Lisa Altschul Disposable portable electronic devices and method of making
US5983094A (en) * 1997-10-27 1999-11-09 Randice-Lisa Altschul Wireless telephone with credited airtime and method
US6126637A (en) * 1998-04-15 2000-10-03 Science Incorporated Fluid delivery device with collapsible needle cover
US6152898A (en) * 1999-04-30 2000-11-28 Medtronic, Inc. Overfill protection systems for implantable drug delivery devices
US6537249B2 (en) * 2000-12-18 2003-03-25 Science, Incorporated Multiple canopy

Patent Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631847A (en) * 1966-03-04 1972-01-04 James C Hobbs Method and apparatus for injecting fluid into the vascular system
US3812843A (en) * 1973-03-12 1974-05-28 Lear Siegler Inc Method and apparatus for injecting contrast media into the vascular system
US4108177A (en) * 1976-04-23 1978-08-22 Michel Louis Paul Pistor Automatic injector device
US4067000A (en) * 1976-05-28 1978-01-03 Rca Corporation Remote control transmitter with an audible battery life indicator
US4211998A (en) * 1977-08-25 1980-07-08 Stierlen-Maquet Aktiengesellschaft Method of and remote control apparatus for remotely controlling a medical appliance
US4151845A (en) * 1977-11-25 1979-05-01 Miles Laboratories, Inc. Blood glucose control apparatus
US4193397A (en) * 1977-12-01 1980-03-18 Metal Bellows Corporation Infusion apparatus and method
US4342311A (en) * 1979-01-08 1982-08-03 Whitney Douglass G Injector with programming means
US4373527B1 (en) * 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4373527A (en) * 1979-04-27 1983-02-15 The Johns Hopkins University Implantable, programmable medication infusion system
US4268150A (en) * 1980-01-28 1981-05-19 Laurence Chen Disposable camera with simplified film advance and indicator
US4601707A (en) * 1980-06-03 1986-07-22 Albisser Anthony M Insulin infusion device
US4424720A (en) * 1980-12-15 1984-01-10 Ivac Corporation Mechanism for screw drive and syringe plunger engagement/disengagement
US4507115A (en) * 1981-04-01 1985-03-26 Olympus Optical Co., Ltd. Medical capsule device
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4435173A (en) * 1982-03-05 1984-03-06 Delta Medical Industries Variable rate syringe pump for insulin delivery
US4498843A (en) * 1982-08-02 1985-02-12 Schneider Philip H Insulin infusion pump
US4514732A (en) * 1982-08-23 1985-04-30 General Electric Company Technique for increasing battery life in remote control transmitters
US4585439A (en) * 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
US4685903A (en) * 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4678408A (en) * 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4562751A (en) * 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4684368A (en) * 1984-06-01 1987-08-04 Parker Hannifin Corporation Inverted pump
US4634427A (en) * 1984-09-04 1987-01-06 American Hospital Supply Company Implantable demand medication delivery assembly
US4808161A (en) * 1986-03-04 1989-02-28 Kamen Dean L Pressure-measurement flow control system
US5533389A (en) * 1986-03-04 1996-07-09 Deka Products Limited Partnership Method and system for measuring volume and controlling flow
USD306691S (en) * 1986-05-23 1990-03-20 Fuji Photo Film Co., Ltd. Disposable camera
USD315727S (en) * 1986-06-30 1991-03-26 Fuji Photo Film Co., Ltd. Disposable camera
US4801857A (en) * 1986-08-27 1989-01-31 Sundstrand Corporation Servo loop control system with dynamic limiting
US4944659A (en) * 1987-01-27 1990-07-31 Kabivitrum Ab Implantable piezoelectric pump system
US4734092A (en) * 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US4898579A (en) * 1987-06-26 1990-02-06 Pump Controller Corporation Infusion pump
US5189609A (en) * 1987-10-09 1993-02-23 Hewlett-Packard Company Medical monitoring system with softkey control
US4836752A (en) * 1987-11-02 1989-06-06 Fisher Scientific Company Partial restriction detector
US4898578A (en) * 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
US5205819A (en) * 1989-05-11 1993-04-27 Bespak Plc Pump apparatus for biomedical use
US5411480A (en) * 1989-06-16 1995-05-02 Science Incorporated Fluid delivery apparatus
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
US5318540A (en) * 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5007458A (en) * 1990-04-23 1991-04-16 Parker Hannifin Corporation Poppet diaphragm valve
US5178609A (en) * 1990-06-19 1993-01-12 Kato Hatsujo Kaisha, Ltd. Medical liquid injector for continuous transfusion
US5125412A (en) * 1990-07-23 1992-06-30 Thornton William E Musculoskeletal activity monitor
US5779696A (en) * 1990-07-23 1998-07-14 Sunrise Technologies International, Inc. Method and apparatus for performing corneal reshaping to correct ocular refractive errors
US5176662A (en) * 1990-08-23 1993-01-05 Minimed Technologies, Ltd. Subcutaneous injection set with improved cannula mounting arrangement
US5312337A (en) * 1990-10-10 1994-05-17 Strato Medical Corporation Catheter attachment device
US5213483A (en) * 1991-06-19 1993-05-25 Strato Medical Corporation Peristaltic infusion pump with removable cassette and mechanically keyed tube set
US5308335A (en) * 1991-06-25 1994-05-03 Medication Delivery Devices Infusion pump, treatment fluid bag therefor, and method for the use thereof
US5281202A (en) * 1991-09-03 1994-01-25 Fresenius Ag Device for draining a flexible fluid container
US5385662A (en) * 1991-11-27 1995-01-31 Electro Chemical Engineering Gmbh Method of producing oxide ceramic layers on barrier layer-forming metals and articles produced by the method
US6024539A (en) * 1992-09-09 2000-02-15 Sims Deltec, Inc. Systems and methods for communicating with ambulatory medical devices such as drug delivery devices
US5433710A (en) * 1993-03-16 1995-07-18 Minimed, Inc. Medication infusion pump with fluoropolymer valve seat
US5747350A (en) * 1993-04-02 1998-05-05 Boehringer Mannheim Gmbh System for dosing liquids
US5704520A (en) * 1993-07-19 1998-01-06 Elan Medical Technologies, Limited Liquid material dispenser and valve
US5514096A (en) * 1993-12-28 1996-05-07 Nissho Corporation Apparatus and balloon for dosing a liquid medicine
US5426404A (en) * 1994-01-28 1995-06-20 Motorola, Inc. Electrical circuit using low volume multilayer transmission line devices
US5764159A (en) * 1994-02-16 1998-06-09 Debiotech S.A. Apparatus for remotely monitoring controllable devices
US5630710A (en) * 1994-03-09 1997-05-20 Baxter International Inc. Ambulatory infusion pump
US5507288B1 (en) * 1994-05-05 1997-07-08 Boehringer Mannheim Gmbh Analytical system for monitoring a substance to be analyzed in patient-blood
US5507288A (en) * 1994-05-05 1996-04-16 Boehringer Mannheim Gmbh Analytical system for monitoring a substance to be analyzed in patient-blood
US5891097A (en) * 1994-08-12 1999-04-06 Japan Storage Battery Co., Ltd. Electrochemical fluid delivery device
US5505709A (en) * 1994-09-15 1996-04-09 Minimed, Inc., A Delaware Corporation Mated infusion pump and syringe
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
US5741228A (en) * 1995-02-17 1998-04-21 Strato/Infusaid Implantable access device
US5647853A (en) * 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
US5776103A (en) * 1995-10-11 1998-07-07 Science Incorporated Fluid delivery device with bolus injection site
US6206850B1 (en) * 1996-03-14 2001-03-27 Christine O'Neil Patient controllable drug delivery system flow regulating means
US5865806A (en) * 1996-04-04 1999-02-02 Becton Dickinson And Company One step catheter advancement automatic needle retraction system
US6190359B1 (en) * 1996-04-30 2001-02-20 Medtronic, Inc. Method and apparatus for drug infusion
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US5755682A (en) * 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US5748827A (en) * 1996-10-23 1998-05-05 University Of Washington Two-stage kinematic mount
US5886647A (en) * 1996-12-20 1999-03-23 Badger; Berkley C. Apparatus and method for wireless, remote control of multiple devices
US5858239A (en) * 1997-02-14 1999-01-12 Aksys, Ltd. Methods and apparatus for adjustment of blood drip chamber of dialysis machines using touchscreen interface
US5785681A (en) * 1997-02-25 1998-07-28 Minimed Inc. Flow rate controller for a medication infusion pump
US5875393A (en) * 1997-02-28 1999-02-23 Randice-Lisa Altschul Disposable wireless telephone and method
US6061580A (en) * 1997-02-28 2000-05-09 Randice-Lisa Altschul Disposable wireless telephone and method for call-out only
US5871470A (en) * 1997-04-18 1999-02-16 Becton Dickinson And Company Combined spinal epidural needle set
US6071292A (en) * 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5858005A (en) * 1997-08-27 1999-01-12 Science Incorporated Subcutaneous infusion set with dynamic needle
US6174300B1 (en) * 1997-08-27 2001-01-16 Science Incorporated Fluid delivery device with temperature controlled energy source
US6527744B1 (en) * 1997-08-27 2003-03-04 Science Incorporated Fluid delivery device with light activated energy source
US6019747A (en) * 1997-10-21 2000-02-01 I-Flow Corporation Spring-actuated infusion syringe
US5897530A (en) * 1997-12-24 1999-04-27 Baxter International Inc. Enclosed ambulatory pump
US6244776B1 (en) * 1998-01-05 2001-06-12 Lien J. Wiley Applicators for health and beauty products
US5919167A (en) * 1998-04-08 1999-07-06 Ferring Pharmaceuticals Disposable micropump
USD405524S (en) * 1998-05-01 1999-02-09 Elan Medical Technologies Limited Drug delivery device
US6585707B2 (en) * 1998-05-21 2003-07-01 Elan Pharma International Limited Drug delivery device having improved adhesion and attachment system for drug delivery device
US5906597A (en) * 1998-06-09 1999-05-25 I-Flow Corporation Patient-controlled drug administration device
US6375638B2 (en) * 1999-02-12 2002-04-23 Medtronic Minimed, Inc. Incremental motion pump mechanisms powered by shape memory alloy wire or the like
US6520936B1 (en) * 1999-06-08 2003-02-18 Medtronic Minimed, Inc. Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
US6427088B1 (en) * 2000-01-21 2002-07-30 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using telemetry system with predefined reception listening periods
US6706159B2 (en) * 2000-03-02 2004-03-16 Diabetes Diagnostics Combined lancet and electrochemical analyte-testing apparatus
US6740059B2 (en) * 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
US6363609B1 (en) * 2000-10-20 2002-04-02 Short Block Technologies, Inc. Method and apparatus for aligning crankshaft sections
US6572585B2 (en) * 2001-07-12 2003-06-03 Soo Bong Choi Remote-controlled portable automatic syringe device
US6692457B2 (en) * 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6723072B2 (en) * 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
US20040068224A1 (en) * 2002-10-02 2004-04-08 Couvillon Lucien Alfred Electroactive polymer actuated medication infusion pumps

Cited By (298)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US20090099523A1 (en) * 2001-05-18 2009-04-16 Grant Kevin L Infusion pump assembly
US20070049870A1 (en) * 2001-05-18 2007-03-01 Deka Products Limited Partnership Infusion Set for a Fluid Pump
US9173996B2 (en) 2001-05-18 2015-11-03 Deka Products Limited Partnership Infusion set for a fluid pump
US8597244B2 (en) 2002-07-24 2013-12-03 Asante Solutions, Inc. Infusion pump system, an infusion pump unit and an infusion pump
US20050160858A1 (en) * 2002-07-24 2005-07-28 M 2 Medical A/S Shape memory alloy actuator
US8961462B2 (en) 2002-07-24 2015-02-24 Asante Solutions, Inc. Infusion pump system, an infusion pump unit and an infusion pump
US9463272B2 (en) 2002-07-24 2016-10-11 Bigfoot Biomedical, Inc. Infusion pump system, an infusion pump unit and an infusion pump
US20050192561A1 (en) * 2002-07-24 2005-09-01 M 2 Medical A/S Infusion pump system, an infusion pump unit and an infusion pump
US20100057038A1 (en) * 2002-10-09 2010-03-04 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US8079984B2 (en) 2002-10-09 2011-12-20 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US8075527B2 (en) 2002-10-09 2011-12-13 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US8066665B2 (en) 2002-10-09 2011-11-29 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US8047812B2 (en) 2002-10-09 2011-11-01 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US20100114029A1 (en) * 2002-10-09 2010-05-06 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US8047811B2 (en) 2002-10-09 2011-11-01 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US8083718B2 (en) 2002-10-09 2011-12-27 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US8172800B2 (en) 2002-10-09 2012-05-08 Abbott Diabetes Care, Inc. Device and method employing shape memory alloy
US20100114028A1 (en) * 2002-10-09 2010-05-06 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US8029245B2 (en) 2002-10-09 2011-10-04 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US20100100041A1 (en) * 2002-10-09 2010-04-22 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US8029250B2 (en) 2002-10-09 2011-10-04 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US20100008794A1 (en) * 2002-10-09 2010-01-14 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US8343093B2 (en) 2002-10-09 2013-01-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US7951114B2 (en) 2002-10-09 2011-05-31 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US8727745B2 (en) 2002-10-09 2014-05-20 Abbott Diabetes Care, Inc. Device and method employing shape memory alloy
US20100114073A1 (en) * 2002-10-09 2010-05-06 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US7959606B2 (en) 2002-10-09 2011-06-14 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US20100076371A1 (en) * 2002-10-09 2010-03-25 Abbott Diabetes Care, Inc. Device and method employing shape memory alloy
US20100063446A1 (en) * 2002-10-09 2010-03-11 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US20100057007A1 (en) * 2002-10-09 2010-03-04 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US20100068072A1 (en) * 2002-10-09 2010-03-18 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US20100241076A1 (en) * 2002-10-09 2010-09-23 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7993109B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7922458B2 (en) 2002-10-09 2011-04-12 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US20100049133A1 (en) * 2002-10-09 2010-02-25 Abbott Diabetes Care, Inc. Device and method employing shape memory alloy
US20100049131A1 (en) * 2002-10-09 2010-02-25 Abbott Diabetes Care, Inc. Device and method employing shape memory alloy
US20100100042A1 (en) * 2002-10-09 2010-04-22 Abbott Diabetes Care, Inc. Device and Method Employing Shape Memory Alloy
US8079983B2 (en) 2002-10-09 2011-12-20 Abbott Diabetes Care Inc. Device and method employing shape memory alloy
US20100049132A1 (en) * 2002-10-09 2010-02-25 Abbott Diabetes Care, Inc. Device and method employing shape memory alloy
US8795233B2 (en) 2002-11-05 2014-08-05 Asante Solutions, Inc. Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US9295777B2 (en) 2002-11-05 2016-03-29 Bigfoot Biomedical, Inc. Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US9757512B2 (en) 2002-11-05 2017-09-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US7887511B2 (en) 2002-11-05 2011-02-15 Asante Solutions, Inc. Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US20050245878A1 (en) * 2002-11-05 2005-11-03 M 2 Medical A/S Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US8801655B2 (en) 2002-11-05 2014-08-12 Asante Solutions, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US9308319B2 (en) 2002-11-05 2016-04-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US20070203459A1 (en) * 2002-12-23 2007-08-30 M2 Medical A/S Flexible Piston Rod
US20100256565A1 (en) * 2002-12-23 2010-10-07 Asante Solutions, Inc. Disposable, Wearable Insulin Dispensing Device, a Combination of Such a Device and a Programming Controller and a Method of Controlling the Operation of Such a Device
US20050273059A1 (en) * 2002-12-23 2005-12-08 M 2 Medical A/S Disposable, wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US7785288B2 (en) 2002-12-23 2010-08-31 Asante Solutions, Inc. Disposable, wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US20050251097A1 (en) * 2002-12-23 2005-11-10 M 2 Medical A/S Flexible piston rod
US8469920B2 (en) 2002-12-23 2013-06-25 Asante Solutions, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US8512246B2 (en) 2003-04-28 2013-08-20 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US8029443B2 (en) 2003-07-15 2011-10-04 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
US20090048501A1 (en) * 2003-07-15 2009-02-19 Therasense, Inc. Glucose measuring device integrated into a holster for a personal area network device
US7722536B2 (en) 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
US7753879B2 (en) 2004-01-29 2010-07-13 M2 Group Holdings, Inc. Disposable medicine dispensing device
US8542122B2 (en) 2005-02-08 2013-09-24 Abbott Diabetes Care Inc. Glucose measurement device and methods using RFID
US8223021B2 (en) 2005-02-08 2012-07-17 Abbott Diabetes Care Inc. RF tag on test strips, test strip vials and boxes
US8390455B2 (en) 2005-02-08 2013-03-05 Abbott Diabetes Care Inc. RF tag on test strips, test strip vials and boxes
US8358210B2 (en) 2005-02-08 2013-01-22 Abbott Diabetes Care Inc. RF tag on test strips, test strip vials and boxes
US8115635B2 (en) 2005-02-08 2012-02-14 Abbott Diabetes Care Inc. RF tag on test strips, test strip vials and boxes
US8029460B2 (en) 2005-03-21 2011-10-04 Abbott Diabetes Care Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US8029459B2 (en) 2005-03-21 2011-10-04 Abbott Diabetes Care Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US8343092B2 (en) 2005-03-21 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US20070185449A1 (en) * 2005-04-06 2007-08-09 Morten Mernoe Actuator with string drive #1
US8226608B2 (en) 2005-04-06 2012-07-24 Asante Solutions, Inc. Medicine dispensing device
US7713238B2 (en) 2005-04-06 2010-05-11 M2 Group Holdings, Inc. Medicine dispensing device
US8905995B2 (en) 2005-04-06 2014-12-09 Asante Solutions, Inc. Medicine dispensing device
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US8089363B2 (en) 2005-05-17 2012-01-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US8471714B2 (en) 2005-05-17 2013-06-25 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US9332944B2 (en) 2005-05-17 2016-05-10 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US7884729B2 (en) 2005-05-17 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US9750440B2 (en) 2005-05-17 2017-09-05 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US8653977B2 (en) 2005-05-17 2014-02-18 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US8112138B2 (en) 2005-06-03 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US9314569B2 (en) 2005-09-26 2016-04-19 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US8105279B2 (en) 2005-09-26 2012-01-31 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US8057436B2 (en) 2005-09-26 2011-11-15 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US20070167905A1 (en) * 2005-09-26 2007-07-19 M2 Medical A/S Operating an Infusion Pump System
US20070073235A1 (en) * 2005-09-26 2007-03-29 Estes Mark C Operating an infusion pump system
US8480623B2 (en) 2005-09-26 2013-07-09 Asante Solutions, Inc. Method for dispensing fluid from an infusion pump system
US9872957B2 (en) 2005-09-26 2018-01-23 Bigfoot Biomedical, Inc. Operating an infusion pump system
US8622966B2 (en) 2005-09-26 2014-01-07 Asante Solutions, Inc. Operating an infusion pump system
US7887512B2 (en) 2005-09-26 2011-02-15 Asante Solutions, Inc. Operating an infusion pump system
US20070156092A1 (en) * 2005-09-26 2007-07-05 M2 Medical A/S Operating an Infusion Pump System
US7776030B2 (en) 2005-09-26 2010-08-17 Asante Solutions, Inc. Operating an infusion pump system
US7794428B2 (en) 2005-09-26 2010-09-14 Asante Solutions, Inc. Operating an infusion pump system
US7794427B2 (en) 2005-09-26 2010-09-14 Asante Solutions, Inc. Operating an infusion pump system
US9814830B2 (en) 2005-09-26 2017-11-14 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US20070073236A1 (en) * 2005-09-26 2007-03-29 Morten Mernoe Dispensing fluid from an infusion pump system
US8409142B2 (en) 2005-09-26 2013-04-02 Asante Solutions, Inc. Operating an infusion pump system
US7922708B2 (en) 2005-09-26 2011-04-12 Asante Solutions, Inc. Operating an infusion pump system
US7789859B2 (en) 2005-09-26 2010-09-07 Asante Solutions, Inc. Operating an infusion pump system
US8696633B2 (en) 2005-09-26 2014-04-15 Asante Solutions, Inc. Operating an infusion pump system
US20080045931A1 (en) * 2005-09-26 2008-02-21 M2 Medical A/S Operating an Infusion Pump System
US7938803B2 (en) 2005-09-26 2011-05-10 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US20110112504A1 (en) * 2005-09-26 2011-05-12 Asante Solutions, Inc. Operating an Infusion Pump System
US7708717B2 (en) 2005-09-26 2010-05-04 M2 Group Holdings, Inc. Operating an infusion pump system
US7981084B2 (en) 2005-09-26 2011-07-19 Asante Solutions, Inc. Operating an infusion pump system
US20070073228A1 (en) * 2005-09-26 2007-03-29 Morten Mernoe Dispensing fluid from an infusion pump system
US8747369B2 (en) 2005-09-26 2014-06-10 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8747368B2 (en) 2005-09-26 2014-06-10 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US20090198186A1 (en) * 2005-09-26 2009-08-06 M2 Group Holdings, Inc. Dispensing Fluid from an Infusion Pump System
US20080045904A1 (en) * 2005-09-26 2008-02-21 M2 Medical A/S Operating an Infusion Pump System
US8282601B2 (en) 2005-09-26 2012-10-09 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US20110190705A1 (en) * 2005-09-26 2011-08-04 Asante Solutions, Inc. Dispensing Fluid from an Infusion Pump System
US9539388B2 (en) 2005-09-26 2017-01-10 Bigfoot Biomedical, Inc. Operating an infusion pump system
US20070167912A1 (en) * 2005-09-26 2007-07-19 M2 Medical A/S Operating an Infusion Pump System
US9517301B2 (en) 2005-09-26 2016-12-13 Bigfoot Biomedical, Inc. Operating an infusion pump system
US20100274108A1 (en) * 2005-09-30 2010-10-28 Abbott Diabetes Care Inc. Method and Apparatus for Providing Rechargeable Power in Data Monitoring and Management Systems
US8638220B2 (en) 2005-10-31 2014-01-28 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US8430847B2 (en) 2005-11-08 2013-04-30 Asante Solutions, Inc. Infusion pump system
US8679060B2 (en) 2005-11-08 2014-03-25 Asante Solutions, Inc. Infusion pump system
US8372039B2 (en) 2005-11-08 2013-02-12 Asante Solutions, Inc. Infusion pump system
US9114209B2 (en) 2005-11-08 2015-08-25 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US8192394B2 (en) 2005-11-08 2012-06-05 Asante Solutions, Inc. Method and system for manual and autonomous control of an infusion pump
US8475408B2 (en) 2005-11-08 2013-07-02 Asante Solutions, Inc. Infusion pump system
US20100256598A1 (en) * 2005-11-08 2010-10-07 Asante Solutions, Inc. Infusion Pump System
US20100256564A1 (en) * 2005-11-08 2010-10-07 Asante Solutions, Inc. Infusion Pump System
US20070124002A1 (en) * 2005-11-08 2007-05-31 M2 Medical A/S Method and System for Manual and Autonomous Control of an Infusion Pump
US9205192B2 (en) 2005-11-08 2015-12-08 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US20100256563A1 (en) * 2005-11-08 2010-10-07 Asante Solutions, Inc. Infusion Pump System
US20070123819A1 (en) * 2005-11-08 2007-05-31 M2 Medical A/S Infusion Pump System
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
US20070228071A1 (en) * 2006-02-09 2007-10-04 Dean Kamen Fluid delivery systems and methods
US20070219480A1 (en) * 2006-02-09 2007-09-20 Dean Kamen Patch-sized fluid delivery systems and methods
US8414522B2 (en) 2006-02-09 2013-04-09 Deka Products Limited Partnership Fluid delivery systems and methods
US8496646B2 (en) 2006-02-09 2013-07-30 Deka Products Limited Partnership Infusion pump assembly
US8585377B2 (en) 2006-02-09 2013-11-19 Deka Products Limited Partnership Pumping fluid delivery systems and methods using force application assembly
US8113244B2 (en) 2006-02-09 2012-02-14 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US20070219597A1 (en) * 2006-02-09 2007-09-20 Dean Kamen Adhesive and peripheral systems and methods for medical devices
US8545445B2 (en) 2006-02-09 2013-10-01 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US20070213657A1 (en) * 2006-02-28 2007-09-13 Abbott Diabetes Care, Inc Smart messages and alerts for an infusion delivery and management system
US9782076B2 (en) 2006-02-28 2017-10-10 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
US20090171269A1 (en) * 2006-06-29 2009-07-02 Abbott Diabetes Care, Inc. Infusion Device and Methods Therefor
US8512244B2 (en) 2006-06-30 2013-08-20 Abbott Diabetes Care Inc. Integrated analyte sensor and infusion device and methods therefor
US9119582B2 (en) 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
US20080004515A1 (en) * 2006-06-30 2008-01-03 Abbott Diabetes Care, Inc. Integrated Analyte Sensor and Infusion Device and Methods Therefor
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US9697332B2 (en) 2006-08-07 2017-07-04 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US8727982B2 (en) 2006-08-07 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US20090054750A1 (en) * 2006-08-07 2009-02-26 Abbott Diabetes Care, Inc. Method and System for Providing Integrated Analyte Monitoring and Infusion System Therapy Management
US20090054745A1 (en) * 2006-08-07 2009-02-26 Abbott Diabetes Care, Inc. Method and System for Providing Data Management in Integrated Analyte Monitoring and Infusion System
US8551046B2 (en) 2006-09-18 2013-10-08 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8202267B2 (en) 2006-10-10 2012-06-19 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US20080086086A1 (en) * 2006-10-10 2008-04-10 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US9064107B2 (en) 2006-10-31 2015-06-23 Abbott Diabetes Care Inc. Infusion devices and methods
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
US20080102119A1 (en) * 2006-11-01 2008-05-01 Medtronic, Inc. Osmotic pump apparatus and associated methods
US20110184389A1 (en) * 2006-11-01 2011-07-28 Medtronic, Inc. Osmotic pump apparatus and associated methods
US20080161754A1 (en) * 2006-12-29 2008-07-03 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US8647302B2 (en) 2007-05-21 2014-02-11 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
US20110118662A1 (en) * 2007-05-21 2011-05-19 Asante Solutions, Inc. Occlusion Sensing for an Infusion Pump
US9440021B2 (en) 2007-05-21 2016-09-13 Bigfoot Biomedical, Inc. Removable controller for an infusion pump
US20080294094A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Occlusion Sensing for an Infusion Pump
US20080294142A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Removable Controller for an Infusion Pump
US20080294108A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Infusion Pump System with Contamination-Resistant Features
US7833196B2 (en) 2007-05-21 2010-11-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
US20080294109A1 (en) * 2007-05-21 2008-11-27 M2 Medical Group Holdings, Inc. Illumination Instrument for an Infusion Pump
US9480793B2 (en) 2007-05-21 2016-11-01 Bigfoot Biomedical, Inc. Occlusion sensing for an infusion pump
US9717849B2 (en) 2007-05-21 2017-08-01 Bigfoot Biomedical, Inc. Occlusion sensing for an infusion pump
US8454575B2 (en) 2007-05-21 2013-06-04 Asante Solutions, Inc. Illumination instrument for an infusion pump
US8152765B2 (en) 2007-05-21 2012-04-10 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
US7981102B2 (en) 2007-05-21 2011-07-19 Asante Solutions, Inc. Removable controller for an infusion pump
US8641673B2 (en) 2007-05-21 2014-02-04 Asante Solutions, Inc. Removable controller for an infusion pump
US8852141B2 (en) 2007-05-21 2014-10-07 Asante Solutions, Inc. Occlusion sensing for an infusion pump
US8834420B2 (en) 2007-05-21 2014-09-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
US8211062B2 (en) 2007-05-21 2012-07-03 Asante Solutions, Inc. Illumination instrument for an infusion pump
US7892199B2 (en) 2007-05-21 2011-02-22 Asante Solutions, Inc. Occlusion sensing for an infusion pump
US20110021992A1 (en) * 2007-05-21 2011-01-27 Asante Solutions, Inc. Illumination Instrument for an Infusion Pump
US9962482B2 (en) 2007-05-21 2018-05-08 Bigfoot Biomedical, Inc. Removable controller for an infusion pump
US7794426B2 (en) 2007-05-21 2010-09-14 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
US9474854B2 (en) 2007-05-21 2016-10-25 Bigfoot Biomedical, Inc. Occlusion sensing for an infusion pump
US20090012377A1 (en) * 2007-06-27 2009-01-08 Abbott Diabetes Care, Inc. Method and structure for securing a monitoring device element
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
US8502682B2 (en) 2007-06-28 2013-08-06 Abbott Diabetes Care Inc. Signal converting cradle for medical condition monitoring and management system
US8085151B2 (en) 2007-06-28 2011-12-27 Abbott Diabetes Care Inc. Signal converting cradle for medical condition monitoring and management system
US20090002179A1 (en) * 2007-06-28 2009-01-01 Abbott Diabetes Care, Inc. Signal converting cradle for medical condition monitoring and management system
US8870853B2 (en) 2007-09-06 2014-10-28 Asante Solutions, Inc. Operating a portable medical device
US20090067989A1 (en) * 2007-09-06 2009-03-12 M2 Medical Group Holdings, Inc. Occlusion Sensing System for Infusion Pumps
US7828528B2 (en) 2007-09-06 2010-11-09 Asante Solutions, Inc. Occlusion sensing system for infusion pumps
US7717903B2 (en) 2007-09-06 2010-05-18 M2 Group Holdings, Inc. Operating an infusion pump system
US8109921B2 (en) 2007-09-06 2012-02-07 Asante Solutions, Inc. Operating a portable medical device
US20110202004A1 (en) * 2007-09-07 2011-08-18 Asante Solutions, Inc. Data Storage for an Infusion Pump System
US20110130716A1 (en) * 2007-09-07 2011-06-02 Asante Solutions, Inc. Activity Sensing Techniques for an Infusion Pump System
US8287514B2 (en) 2007-09-07 2012-10-16 Asante Solutions, Inc. Power management techniques for an infusion pump system
US8328754B2 (en) 2007-09-07 2012-12-11 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US8211093B2 (en) 2007-09-07 2012-07-03 Asante Solutions, Inc. Data storage for an infusion pump system
US8622990B2 (en) 2007-09-07 2014-01-07 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US8551070B2 (en) 2007-09-07 2013-10-08 Asante Solutions, Inc. User profile backup system for an infusion pump device
US9381302B2 (en) 2007-09-07 2016-07-05 Bigfoot Biomedical, Inc. User profile backup system for an infusion pump device
US8032226B2 (en) 2007-09-07 2011-10-04 Asante Solutions, Inc. User profile backup system for an infusion pump device
US9415158B2 (en) 2007-09-07 2016-08-16 Bigfoot Biomedical, Inc. Power management techniques for an infusion pump system
US7935076B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US20090069787A1 (en) * 2007-09-07 2009-03-12 M2 Medical Activity Sensing Techniques for an Infusion Pump System
US9254362B2 (en) 2007-09-07 2016-02-09 Bigfoot Biomedical, Inc. Activity sensing techniques for an infusion pump system
US7935105B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Data storage for an infusion pump system
US7879026B2 (en) 2007-09-07 2011-02-01 Asante Solutions, Inc. Controlled adjustment of medicine dispensation from an infusion pump device
US8685002B2 (en) 2007-09-07 2014-04-01 Asante Solutions, Inc. Data storage for an infusion pump system
US9522232B2 (en) 2007-09-07 2016-12-20 Bigfoot Biomedical, Inc. Data storage for an infusion pump system
US20090069746A1 (en) * 2007-09-07 2009-03-12 M2 Medical Group Holdings, Inc. Data Storage for an Infusion Pump System
US8894628B2 (en) 2007-09-07 2014-11-25 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US20110040252A1 (en) * 2007-10-16 2011-02-17 Peter Gravesen Cannula Insertion Device and Related Methods
US9968747B2 (en) 2007-10-16 2018-05-15 Cequr Sa Cannula insertion device and related methods
US9005169B2 (en) 2007-10-16 2015-04-14 Cequr Sa Cannula insertion device and related methods
US20110082439A1 (en) * 2007-12-12 2011-04-07 Asante Solutions, Inc. Portable Infusion Pump and Media Player
US9314566B2 (en) 2007-12-12 2016-04-19 Bigfoot Biomedical, Inc. Portable infusion pump and media player
US7875022B2 (en) 2007-12-12 2011-01-25 Asante Solutions, Inc. Portable infusion pump and media player
US8282626B2 (en) 2007-12-12 2012-10-09 Asante Solutions, Inc. Portable infusion pump and media player
US20090156990A1 (en) * 2007-12-12 2009-06-18 M2 Medical Group Holdings, Inc. Portable Infusion Pump and Media Player
US20090281497A1 (en) * 2007-12-31 2009-11-12 Dean Kamen Wearable pump assembly
US9526830B2 (en) 2007-12-31 2016-12-27 Deka Products Limited Partnership Wearable pump assembly
US20090299289A1 (en) * 2007-12-31 2009-12-03 Dean Kamen Pump assembly with switch
US8491570B2 (en) 2007-12-31 2013-07-23 Deka Products Limited Partnership Infusion pump assembly
US8414563B2 (en) 2007-12-31 2013-04-09 Deka Products Limited Partnership Pump assembly with switch
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8708961B2 (en) 2008-01-28 2014-04-29 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
US20100331826A1 (en) * 2008-01-28 2010-12-30 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
US8448824B2 (en) 2008-09-16 2013-05-28 Tandem Diabetes Care, Inc. Slideable flow metering devices and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US20100094222A1 (en) * 2008-10-10 2010-04-15 Grant Kevin L Infusion pump assembly
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US20100094215A1 (en) * 2008-10-10 2010-04-15 Grant Kevin L Pump assembly with a removable cover assembly
US20100089475A1 (en) * 2008-10-10 2010-04-15 Tracey Brian D Medium connector
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US9782536B2 (en) 2009-01-12 2017-10-10 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US8573027B2 (en) 2009-02-27 2013-11-05 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
US9764083B1 (en) 2009-07-23 2017-09-19 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US8939928B2 (en) 2009-07-23 2015-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US20110022025A1 (en) * 2009-07-23 2011-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US8798934B2 (en) 2009-07-23 2014-08-05 Abbott Diabetes Care Inc. Real time management of data relating to physiological control of glucose levels
US8758323B2 (en) 2009-07-30 2014-06-24 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8298184B2 (en) 2009-07-30 2012-10-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9211377B2 (en) 2009-07-30 2015-12-15 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8926561B2 (en) 2009-07-30 2015-01-06 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8287495B2 (en) 2009-07-30 2012-10-16 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US20110043357A1 (en) * 2009-08-18 2011-02-24 Greg Peatfield Methods for detecting failure states in a medicine delivery device
US9174009B2 (en) 2009-08-18 2015-11-03 Cequr Sa Methods for detecting failure states in a medicine delivery device
US9039654B2 (en) 2009-08-18 2015-05-26 Cequr Sa Medicine delivery device having detachable pressure sensing unit
US8547239B2 (en) 2009-08-18 2013-10-01 Cequr Sa Methods for detecting failure states in a medicine delivery device
US9022972B2 (en) 2009-08-18 2015-05-05 Cequr Sa Medicine delivery device having detachable pressure sensing unit
US9694147B2 (en) 2009-08-18 2017-07-04 Cequr Sa Methods for detecting failure states in a medicine delivery device
US20110046558A1 (en) * 2009-08-18 2011-02-24 Peter Gravesen Medicine delivery device having detachable pressure sensing unit
US8672873B2 (en) 2009-08-18 2014-03-18 Cequr Sa Medicine delivery device having detachable pressure sensing unit
US9375529B2 (en) 2009-09-02 2016-06-28 Becton, Dickinson And Company Extended use medical device
US20110054285A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Flexible and Conformal Patch Pump
US20110054390A1 (en) * 2009-09-02 2011-03-03 Becton, Dickinson And Company Extended Use Medical Device
US9750444B2 (en) 2009-09-30 2017-09-05 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
USD691258S1 (en) 2010-05-27 2013-10-08 Asante Solutions, Inc. Infusion pump
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US9480792B2 (en) 2010-11-30 2016-11-01 Becton, Dickinson And Company Ballistic microneedle infusion device
US9844635B2 (en) 2010-11-30 2017-12-19 Becton, Dickinson And Company Adjustable height needle infusion device
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion
US9259529B2 (en) 2011-02-09 2016-02-16 Bigfoot Biomedical, Inc. Infusion pump systems and methods
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
US8454581B2 (en) 2011-03-16 2013-06-04 Asante Solutions, Inc. Infusion pump systems and methods
US9801997B2 (en) 2011-03-16 2017-10-31 Bigfoot Biomedical, Inc. Infusion pump systems and methods
US9132234B2 (en) 2011-03-16 2015-09-15 Bigfoot Biomedical, Inc. Infusion pump systems and methods
US8585657B2 (en) 2011-06-21 2013-11-19 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8808230B2 (en) 2011-09-07 2014-08-19 Asante Solutions, Inc. Occlusion detection for an infusion pump system
US9610404B2 (en) 2011-09-07 2017-04-04 Bigfoot Biomedical, Inc. Method for occlusion detection for an infusion pump system
US9623173B2 (en) 2012-03-05 2017-04-18 Becton, Dickinson And Company Wireless communication for on-body medical devices
US8454557B1 (en) 2012-07-19 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US9545476B2 (en) 2012-07-19 2017-01-17 Bigfoot Biomedical, Inc. Infusion pump system and method
US8945044B2 (en) 2012-07-19 2015-02-03 Asante Solutions, Inc. Infusion pump system and method
US8454562B1 (en) 2012-07-20 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US9517300B2 (en) 2012-07-20 2016-12-13 Bigfoot Biomedical, Inc. Pump system and method
US9427523B2 (en) 2012-12-10 2016-08-30 Bigfoot Biomedical, Inc. Infusion pump system and method
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
US9956339B2 (en) 2013-06-03 2018-05-01 Bigfoot Biomedical, Inc. Infusion pump system and method
US9446187B2 (en) 2013-06-03 2016-09-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
USD809134S1 (en) 2016-03-10 2018-01-30 Bigfoot Biomedical, Inc. Infusion pump assembly

Also Published As

Publication number Publication date Type
WO2004006981A3 (en) 2009-08-06 application
US7018360B2 (en) 2006-03-28 grant
WO2004006981A2 (en) 2004-01-22 application
US20040015131A1 (en) 2004-01-22 application

Similar Documents

Publication Publication Date Title
US5693018A (en) Subdermal delivery device
US4813937A (en) Ambulatory disposable infusion delivery system
US5368588A (en) Parenteral fluid medication reservoir pump
US4619652A (en) Dosage form for use in a body mounted pump
US6527744B1 (en) Fluid delivery device with light activated energy source
US6494867B1 (en) Medical device
US5785688A (en) Fluid delivery apparatus and method
US4944659A (en) Implantable piezoelectric pump system
US7569050B2 (en) Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion
US4013074A (en) Implantable medication-dispensing device
US20080009805A1 (en) Integrated package
US4552561A (en) Body mounted pump housing and pump assembly employing the same
US8062253B2 (en) Medical skin mountable device
US7524304B2 (en) Drug infusion device
EP1495775A1 (en) Portable drug delivery device having an encapsulated needle
US4734092A (en) Ambulatory drug delivery device
US5188603A (en) Fluid infusion delivery system
US7918825B2 (en) Interfacing a prefilled syringe with an infusion pump to fill the infusion pump
US20070299398A1 (en) Infusion device capable of providing multiple liquid medicaments
US8298172B2 (en) Medical skin mountable device and system
US20070088271A1 (en) Medication device
US20050038379A1 (en) Microfluidic device for drug delivery
US20070255235A1 (en) Septum monitoring system and method for an implantable therapeutic substance delivery device
US20070049865A1 (en) Retraction means for transcutaneous device
US7144384B2 (en) Dispenser components and methods for patient infusion device

Legal Events

Date Code Title Description
AS Assignment

Owner name: INSULET CORPORATION, MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MORONEY, RICHARD MORGAN;GARIBOTTO, JOHN;FLAHERTY, J. CHRISTOPHER;AND OTHERS;REEL/FRAME:016636/0479;SIGNING DATES FROM 20050716 TO 20050718

AS Assignment

Owner name: INSULET CORPORATION, MASSACHUSETTS

Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEERFIELD PRIVATE DESIGN FUND, L.P., DEERFIELD PRIVATE DESIGN INTERNATIONAL, L.P., DEERFIELD PARTNERS, L.P. AND DEERFIELD INTERNATIONAL LIMITED;REEL/FRAME:044592/0728

Effective date: 20120930