EP1463534A1 - Nouveau procede pour steriliser et desinfecter des produits agricoles et botaniques - Google Patents
Nouveau procede pour steriliser et desinfecter des produits agricoles et botaniquesInfo
- Publication number
- EP1463534A1 EP1463534A1 EP02797250A EP02797250A EP1463534A1 EP 1463534 A1 EP1463534 A1 EP 1463534A1 EP 02797250 A EP02797250 A EP 02797250A EP 02797250 A EP02797250 A EP 02797250A EP 1463534 A1 EP1463534 A1 EP 1463534A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- source
- atomic oxygen
- nascent
- hydrogen peroxide
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims description 87
- 230000001954 sterilising effect Effects 0.000 title claims description 31
- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 26
- 230000008569 process Effects 0.000 title description 34
- 230000000249 desinfective effect Effects 0.000 title description 2
- 239000000843 powder Substances 0.000 claims abstract description 106
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 64
- 239000001301 oxygen Substances 0.000 claims abstract description 32
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 32
- 244000005700 microbiome Species 0.000 claims abstract description 26
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 152
- 238000002156 mixing Methods 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 244000134552 Plantago ovata Species 0.000 claims description 22
- 235000003421 Plantago ovata Nutrition 0.000 claims description 22
- 239000009223 Psyllium Substances 0.000 claims description 22
- 229940070687 psyllium Drugs 0.000 claims description 22
- 239000010903 husk Substances 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 12
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims description 11
- 239000007921 spray Substances 0.000 claims description 7
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 5
- 229940045872 sodium percarbonate Drugs 0.000 claims description 5
- 235000014134 echinacea Nutrition 0.000 claims description 4
- 235000013599 spices Nutrition 0.000 claims description 4
- 239000010369 Cascara Substances 0.000 claims description 3
- 241000556215 Frangula purshiana Species 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 229940058505 cascara Drugs 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 241000208340 Araliaceae Species 0.000 claims 1
- 241000258180 Echinacea <Echinodermata> Species 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 4
- 239000007800 oxidant agent Substances 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 230000001590 oxidative effect Effects 0.000 abstract description 3
- 230000000813 microbial effect Effects 0.000 description 38
- 238000001035 drying Methods 0.000 description 21
- 239000000243 solution Substances 0.000 description 20
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 19
- 239000000126 substance Substances 0.000 description 19
- 238000012360 testing method Methods 0.000 description 19
- 241000588724 Escherichia coli Species 0.000 description 18
- 241000607142 Salmonella Species 0.000 description 18
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- 241001632410 Eleutherococcus senticosus Species 0.000 description 17
- 238000004458 analytical method Methods 0.000 description 17
- 238000012545 processing Methods 0.000 description 15
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- 239000000463 material Substances 0.000 description 13
- 238000004128 high performance liquid chromatography Methods 0.000 description 9
- 238000005227 gel permeation chromatography Methods 0.000 description 8
- 150000004676 glycans Chemical class 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
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- 229920001282 polysaccharide Polymers 0.000 description 7
- 239000005017 polysaccharide Substances 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- YDDGKXBLOXEEMN-IABMMNSOSA-N chicoric acid Chemical compound O([C@@H](C(=O)O)[C@@H](OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)\C=C\C1=CC=C(O)C(O)=C1 YDDGKXBLOXEEMN-IABMMNSOSA-N 0.000 description 6
- 238000001694 spray drying Methods 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 240000003444 Paullinia cupana Species 0.000 description 5
- 235000000556 Paullinia cupana Nutrition 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 238000005507 spraying Methods 0.000 description 5
- 238000005481 NMR spectroscopy Methods 0.000 description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- -1 peroxide compounds Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- YDDGKXBLOXEEMN-IABMMNSOSA-L Chicoric acid Natural products C1=C(O)C(O)=CC=C1\C=C\C(=O)O[C@@H](C([O-])=O)[C@H](C([O-])=O)OC(=O)\C=C\C1=CC=C(O)C(O)=C1 YDDGKXBLOXEEMN-IABMMNSOSA-L 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- YDDGKXBLOXEEMN-UHFFFAOYSA-N Di-E-caffeoyl-meso-tartaric acid Natural products C=1C=C(O)C(O)=CC=1C=CC(=O)OC(C(O)=O)C(C(=O)O)OC(=O)C=CC1=CC=C(O)C(O)=C1 YDDGKXBLOXEEMN-UHFFFAOYSA-N 0.000 description 3
- FFDULTAFAQRACT-JSGUJALWSA-N Eleutheroside E Chemical compound COC1=CC([C@@H]2[C@@H]3[C@H]([C@@H](OC3)C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=C(OC)C=3)CO2)=CC(OC)=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FFDULTAFAQRACT-JSGUJALWSA-N 0.000 description 3
- FFDULTAFAQRACT-MWBGVTEFSA-N Eleutheroside E Natural products COc1cc(cc(OC)c1O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@@H]3OC[C@H]4[C@H]3CO[C@@H]4c5cc(OC)c(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c(OC)c5 FFDULTAFAQRACT-MWBGVTEFSA-N 0.000 description 3
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 229930016920 cichoric acid Natural products 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- YDDGKXBLOXEEMN-PMACEKPBSA-N dicaffeoyl-D-tartaric acid Natural products O([C@H](C(=O)O)[C@H](OC(=O)C=CC=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)C=CC1=CC=C(O)C(O)=C1 YDDGKXBLOXEEMN-PMACEKPBSA-N 0.000 description 3
- YDDGKXBLOXEEMN-WOJBJXKFSA-N dicaffeoyl-L-tartaric acid Natural products O([C@@H](C(=O)O)[C@@H](OC(=O)C=CC=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)C=CC1=CC=C(O)C(O)=C1 YDDGKXBLOXEEMN-WOJBJXKFSA-N 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000013024 dilution buffer Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000002070 germicidal effect Effects 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- QJVXKWHHAMZTBY-GCPOEHJPSA-N syringin Chemical compound COC1=CC(\C=C\CO)=CC(OC)=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 QJVXKWHHAMZTBY-GCPOEHJPSA-N 0.000 description 3
- QJVXKWHHAMZTBY-KSXIZUIISA-N syringin Natural products COc1cc(C=CCO)cc(OC)c1O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O QJVXKWHHAMZTBY-KSXIZUIISA-N 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 244000133098 Echinacea angustifolia Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- 240000004658 Medicago sativa Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910001447 ferric ion Inorganic materials 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-N hydroperoxyl Chemical compound O[O] OUUQCZGPVNCOIJ-UHFFFAOYSA-N 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 2
- 239000012449 sabouraud dextrose agar Substances 0.000 description 2
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- 238000003860 storage Methods 0.000 description 2
- 239000006150 trypticase soy agar Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 240000004530 Echinacea purpurea Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000010624 Medicago sativa Nutrition 0.000 description 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
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- 150000001298 alcohols Chemical class 0.000 description 1
- 239000010868 animal carcass Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
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- 230000001580 bacterial effect Effects 0.000 description 1
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- 230000033228 biological regulation Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229940071704 cascara sagrada Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000009690 centrifugal atomisation Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
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- 238000006731 degradation reaction Methods 0.000 description 1
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- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
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- 229910001448 ferrous ion Inorganic materials 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- CUILPNURFADTPE-UHFFFAOYSA-N hypobromous acid Chemical compound BrO CUILPNURFADTPE-UHFFFAOYSA-N 0.000 description 1
- 229940030980 inova Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000010338 mechanical breakdown Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- QCAWEPFNJXQPAN-UHFFFAOYSA-N methoxyfenozide Chemical compound COC1=CC=CC(C(=O)NN(C(=O)C=2C=C(C)C=C(C)C=2)C(C)(C)C)=C1C QCAWEPFNJXQPAN-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000006385 ozonation reaction Methods 0.000 description 1
- 239000000590 phytopharmaceutical Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 238000000746 purification Methods 0.000 description 1
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- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
- A61L2/186—Peroxide solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/12—Apparatus for isolating biocidal substances from the environment
- A61L2202/122—Chambers for sterilisation
Definitions
- the present invention relates generally to the sterilization and disinfection of agricultural and botanical products such as botanical powders. More particularly, the present invention is directed towards the use of heterogeneous biphase sterilization (HBS) technology whereby contaminated agricultural products are contacted with an oxidant such as nascent atomic oxygen and or hydroxyl radicals thus resulting in the oxidization and destruction of the contaminating microorganisms.
- HBS heterogeneous biphase sterilization
- Herbal powders comprise a large portion of the botanical products sold in the dietary supplement market. These powders are processed by milling raw whole herbs or plants. The resultant powders have a natural profile of chemical constituents unaltered from the plants themselves. However, they also are generally contaminated with the same microbial organisms found on the botanical raw materials which are harvested from farms or are collected from wild fields. Therefore, it is essential to remove the microbial contamination from the herbal powders before they are incorporated into a finished dose form and sold into the market.
- U.S. Pat. No. 5,711 ,981 issued January 27, 1998 to Wilson, et al., describes treating meats by removing surface water by air blowing, steam heating at pressure greater than atmospheric, and chilling by spraying with water.
- one object of this invention is to provide a method and apparatus for the sterilization and disinfection of agricultural products.
- Another object of this invention is to provide a method of effectively killing microorganisms that exist within botanical powders.
- the process of this invention may comprise contacting at ambient pressure microbial contaminated surfaces with nascent oxygen and or hydroxyl radicals.
- FIG. 1 is a schematic diagram illustrating the Heterogeneous Biphase Sterilization (HBS) process of this invention as applied to a spray drying system.
- HBS Heterogeneous Biphase Sterilization
- Figure 2 is a schematic diagram illustrating an alternative embodiment of the HBS process of this invention as applied to a spray drying system.
- Figure 3 is a perspective view illustrating the HBS process of this invention as applied to a modified ribbon blender system.
- Figure 4 is a schematic diagram illustrating the HBS process of this invention as applied to a fluid bed system.
- Figure 5 is an HPLC chromatogram demonstrating that the chemical compositions of a treated Siberian ginseng powder before and after processing have been maintained without significant changed through the sterilization process of the present invention.
- Figure 6 is an HPLC chromatogram demonstrating that the chemical compositions of a treated Echinacea purpera powder before and after processing, have been maintained with out significant change through the sterilization process of the present invention.
- Figure 7 is a HPLC chromatogram demonstrating that the chemical compositions of an treated Guarana seeds powder before and after processing, have not been significantly changed through the sterilization process of the present invention.
- Figure 8 is a GPC (gel permeation chromatography) chromatogram demonstrating that the chemical compositions of polysaccharides of a treated Psyllium husk before and after processing, have not been significantly changed through the sterilization process of the present invention.
- Figure 9 is a GPC chromatogram demonstrating that the chemical compositions of a treated Psyllium milled powder before and after processing, have not been significantly changed through the sterilization process of the present invention.
- Figure 10 is an 1 H NMR spectra demonstrating that the proton profile of a treated Psyllium before and after processing have not been significantly changed through the sterilization process of the present invention.
- nascent oxygen is characterized by excessive chemical activity that is capable of functioning as a germicide. Since nascent oxygen is a very short acting element, harnessing its germicidal properties for use on specific types of materials is a difficult undertaking. Forming hydroxyl radicals or perhydroxyl radicals from peroxide compounds are also possible if certain reducing or oxidizing agents exist.
- ferrous ions (Fe 2+ ) catalytically convert hydrogen peroxide into hydroxyl radical and ferric ions (Fe 3+ ) convert H 2 O 2 into perhydroxyl radical.
- the source of energy may be but is not limited to heat, irradiation (UV), or an enzyme.
- the process of the present invention exploits the germicidal properties of nascent oxygen, but does not exclude the possibilities of hydroxyl and perhydroxyl radicals, by creating an environment at ambient pressures wherein nascent oxygen is produced and immediately contacted with a surface having microbial contamination whereupon the microbial contaminate is oxidized and thus killed.
- any good such as, but not limited to spice, gum, dried vegetable, botanical products in the form of powders, roots, husks, fruits, flowers, barks, leaves, flowers and seeds, or any instrument (organic or inorganic) having a surface capable of being contaminated with microbial organisms, is placed in an environment that is not deleterious to the chemical constituents of the goods or the instrument. Accordingly, once the botanical powder has been exposed to this, "environmental friendly process" the botanical powder is exposed to a nascent oxygen source and a source of energy that will cause the nascent oxygen to be released.
- HBS process 10 of the present invention is shown in Figure 1.
- Figure 1 there is shown in schematic diagram, a mixing and sterilization operation utilizing the HBS process of this invention.
- the initial stage of the process involves the formulation of feed 12 of agricultural or botanical products such as botanical powders with a source of nascent oxygen and/or hydroxyl radicals which may include hydrogen peroxide (H 2 O 2 ), however other sources of nascent oxygen such as but not limited to peroxyacetic acid, percarbonates, such as sodium percarbonate may be used.
- Hydrogen peroxide is the preferred source of nascent oxygen and hydroxyl radicals.
- nascent oxygen and hydroxyl radicals are two of the most reactive chemical species, weaker only to the element fluorine, but stronger than ozone, perhydroxyl radical, permangnate, hypobromous acid, chlorine dioxide, chlorine, etc. in their oxidation potential.
- Hydrogen peroxide is also advantageous since it also produces hydroxyl radicals that also act as oxidants thus further assisting in the oxidation and elimination of microorganisms.
- Hydrogen peroxide is a natural metabolite of many organisms and it is also formed by the action of sunlight on water - a natural purification system for our environment. Hydrogen peroxide is very unstable and is easily decomposed in air, by increasing temperature, or by reducing agents, to form oxygen and water.
- Feed 12 is formed by mixing a known quantity of botanical powder with hydrogen peroxide in the range of 1% - 10% (H 2 O 2 weight to botanical weight and water in the range of 10% - 60% (botanical weight to total weight).
- H 2 O 2 weight to botanical weight a known quantity of botanical powder with hydrogen peroxide in the range of 1% - 10%
- water a known quantity of botanical powder with hydrogen peroxide in the range of 10% - 60% (botanical weight to total weight).
- 100kg of 35% hydrogen peroxide solution may be mixed in to achieve a 3.2% H 2 O 2 level and 2700kg water may be added to achieve about 26% of solid in solution.
- Feed 12 may be mixed at room temperature or may be mixed at heated conditions up to 50-60°C. It is important to note that while heating feed 12 at higher temperature may in fact degrade the hydrogen peroxide and thereby produce nascent oxygen resulting in reduced microbes, the excessive heat will also damage or "cook" the chemical constituents of the botanical powder, thus destroying the desired product. Furthermore, while given enough time the hydrogen peroxide will naturally degrade and thus produce nascent oxygen it is important that feed 12 be processed upon formation otherwise the aqueous solution may actually start to extract the chemical constituents from the botanical powder thus also destroying the product that is to be decontaminated.
- the surprising discovery of the present invention was that hydrogen peroxide alone is not sufficient to kill microorganisms, but that the hydrogen peroxide had to be degraded at certain conditions as described in this process to release nascent atomic oxygen and hydrogen radicals which killed the microorganisms efficiently.
- pump 16 directs feed 12 through nozzle 18 and into drying chamber 20.
- Feed 12 is brought to the required pressure by virtue of pump 16 and is subsequently atomized into particles 22 through nozzle 18.
- Nozzle 18 may be a one component nozzle, a two component nozzle or it may be a centrifugal atomization system.
- Drying chamber 20 simultaneously also receives heated drying air 24. Heated drying air 24 is introduced into drying chamber 20 at a temperature in the range of 200°F - 500°F and preferably about 250-450°F. The temperature of drying air 24 will result in the release of nascent oxygen which subsequently contacts the surface of particles 22 thereby oxidizing and destroying contaminating microorganisms residing thereon. In the event that hydrogen peroxide is used as the source for nascent oxygen, hydroxyl radicals will also be produced and these radicals will further destroy contaminating microorganisms.
- Decontaminated or sterilized particles 22' drop to the bottom of drying chamber 20 and exit drying chamber 20 together with the outgoing air 24' which is now significantly less than 400°F.
- the particles 22 drop through drying chamber 20 so rapidly that the temperature of drying air 24 has no significant effect on the chemical constituents making up particle 22.
- the brief exposure to drying air 24 is adequate to degrade the hydrogen peroxide that is present and thereby produce nascent atomic oxygen.
- drying chamber 20 In a typical spray drying plant, upon exiting the drying chamber 20 decontaminated particles 22' and outgoing air 24' will be received by cyclone 26.
- a ventilator removes the outgoing air 24', which in many cases is also passed through a filter and a scrubber, while sterilized particles 22' exit through the bottom of cyclone 26 where they are gathered and stored (not shown) for further processing or packaging.
- Drying chamber 20 illustrated above is a standard unidirectional spray dryer, however it is contemplated that with appropriate modifications one skilled in the art would be able to identify the necessary parameters to successfully utilize a counter- current or mixed-flow (not shown) spray dryer.
- drying chamber 120 is brought up to its operational temperature by introducing hot drying air 124. Once the drying chamber 120 is at its operational temperature in the range of 200°F - 500°F botanical powder 122 and a source of nascent atomic oxygen are simultaneously introduced into drying chamber 120.
- Botanical powder 122 contaminated with microorganisms
- the source of nascent atomic oxygen such as but not limited to hydrogen peroxide 112, stored in vessel 114, is also pumped directly into drying chamber 120 through nozzle 118.
- the HBS process 210 of the present invention may be accomplished by placing the contaminated botanical powder 222 may be placed within a modified stainless steel vessel 220 such as a ribbon blender.
- the modification made to the ribbon blender is the addition of a pair of manifolds with spray nozzles.
- This modification allows the hydrogen peroxide solution to be distributed in the blender uniformly throughout the process.
- the additional modification made to the ribbon blender is the addition of a heating jacket (not shown) placed adjacent to the entire outside surface 221 of the vessel 220.
- a vessel having hollow sidewalls could be constructed so that water or any other thermally conducting fluid, such as but not limited to oils, and alcohols, could flow through the sidewalls in a completely contained manner and the temperature of the water could easily be varied.
- brace 232 Attached to the upper ends 230 and 230' of vessel 220 is at least one brace 232 which traverses the length of vessel 220 and supports the mounting of nozzles 218. In the alternative, brace 232 could be mounted across the width of vessel 220.
- the processing sequence according to the present embodiment thus allows for the ribbon blender 220 to mix and heat the botanical powder 222.
- the internal sidewall 232 of vessel 220 is maintained at a temperature in the range of 40°C- 100°C and preferably maintained at 50°C-80°C.
- a source of nascent oxygen 219 such as but not limited to hydrogen peroxide solution, is directed through nozzles 218 thus allowing the source of nascent oxygen 219 to come in contact with the heated botanical powder 222.
- the source of nascent oxygen 219 is mixed into the botanical powder and as the source of nascent oxygen 219 comes in contact with the internal sidewall 234 the existing heat results in the release of nascent oxygen.
- the nascent oxygen is released it oxidizes and destroys the existing contaminating microorganisms that it comes into contact with.
- Mixing continues for a period of 5 minutes to 180 minutes depending upon the volume of botanical powder 222.
- an outfeed door 236 is closed until the botanical powder is thoroughly mixed and the decontamination and sterilization has been completed.
- the sterilized botanical powder 222' is cooled down by flowing cold water through the jacket for 1-3 hours and followed by discharge into a storage bin or drum (not shown) and held for further processing or packaging.
- a 3-10kg of 35% hydrogen peroxide solution has been found effective to sterilize 1000kg of powder 222.
- the ratio of hydrogen peroxide to botanical powders may vary and is dependent upon the initial microbial load of the botanical powder 222.
- the HBS process 310 takes place within a fluid bed 320, as shown in Figure 4.
- Fluid bed 320 is constructed so that contaminated botanical powder 322 is first loaded into fluid bed chamber 323 through hatch 321. Heated air 324 is then introduced into fluid bed chamber 323 at a temperature in the range of 30°C - 100°C and preferably about 60-80°C. Heated air 324 is directed through an air permeable membrane 328 into the interior of fluid bed 320 by directional vanes 326. Air permeable membrane 328 has a pore size that is large enough to allow air to readily pass through but small enough to keep the botanical powder
- nascent oxygen 319 such as but not limited to hydrogen peroxide, is directed through nozzles 318 thus allowing the source of nascent oxygen 319 to come in contact with the heated botanical powder 322.
- a source of nascent oxygen 319 is mixed with the botanical powder and as the source of nascent oxygen 319 comes in contact with the heated air
- Total Aerobic Count (TAC) and Yeast & Mold (Y&M) Count were tested by using the BioMerieux Bactometer method.
- TAC Total Aerobic Count
- Y&M Yeast & Mold
- One gram of sample was added to 99 mL of phosphate dilution buffer (pH 7.2 ⁇ 0.2) (for 1000cfu/g cutoff), or 10 gram of sample was added to 90 mL of phosphate dilution buffer (for 100cfu/g cutoff).
- the mixture was shaken to mix well and a pipette was used to transfer 0.1 mL of this dilution into duplicated wells of a prepared General Purpose Media Bactometer module (for TPC) and a prepared Yeast and Mold Media Bactometer module (for Y&M).
- the TPC module was incubated in a 35°C bactometer chamber for 24 hours and the Y&M module was incubated in a 25°C bactometer chamber for 48 hours.
- the growth of the microorganism was monitored by the Bactometer Processing System. Based on the results of Bactometer screening, TPC and Y&M counts were confirmed following the procedures published in USP 24. Ten grams of samples were used for analysis. Phosphate dilution buffer or Triptic Soy Broth (TSB) was used for dilution of the samples to expected concentration for yielding 30 to 300 colonies using 1 or 2.5 mL of dilution for each plate.
- TPB Triptic Soy Broth
- TSA Tryptic Soy Agar
- SDA Sabouraud Dextrose Agar
- Residual hydrogen peroxide was tested using EM Quant® Peroxide Test kits (EM Science, Gibbstown, New Jersey). 0.5-1 g of powder was added into 2-4mL of distilled water (or ethanol or acetone, in the case of organic solvent). The solution was then mixed and sonicated for 5 minutes at room temperature. After sonication, the solution was filtered through a 0.45 ⁇ filter for further use. Dip the test strip into the solution for 1 second. Remove the test strip, shake off excess liquid and compare the reaction zone with color scale after 15 seconds. In the case of organic solvents, dip the test strip into the solution for 1 second. Move the test strip slightly to and fro for 3-30 seconds until the solvent has evaporated from the reaction zone. The rest of the procedure is the same as in the water solution.
- HPLC high performance liquid chromatography
- HPLC conditions included the use of a Phenomenex, Prodigy ODS (5 ⁇ m, 4 IDx125 mm) column or equivalent C-18 column.
- GPC Gel permeation chromatography
- PL aquagel-OH 30, (8 ⁇ m, 7.8 IDx30) The proton nuclear magnetic resonance (NMR) spectra were acquired on Unity Inova 400 system, Varian.
- KH-14-31 1000kg of Siberian ginseng (Eleutherococcus senticosus) powder (Lot no. 011-2599) was charged into a modified ribbon blender. 100 kg of 35% hydrogen peroxide solution was sprayed through nozzles within 2 minutes during the blending. After dispersion of the hydrogen peroxide (HP) solution, the mixing powder was then heated for 30 minutes at 50-60°C. A sample (KH-14-31) was taken for microbial test. The untreated material showed a total aerobic count more than 80,000 cfu/g (generally from 10,000 to 100,000 cfu/g), yeast and mold more than 20,000cfu/g and positive on E. coli and Salmonella. After treatment, this sample showed that the total aerobic count is reduced to less than 1000 cfu/g, E. coli and Salmonella were non-detectable as well as yeast and mold were less than 100cfu/g as illustrated in Table 1.
- Eleutheroside B and E are used as marks in the standardized Siberian ginseng product on the marketplace. It was observed that the contents of eleutheroside B and E, analyzed by high performance liquid chromatography (HPLC), in Siberian ginseng powder (011-2599) before and after processing, are similar and the chromatogram profile are identical, indicating that the chemical compositions have not been significantly changed through this sterilization process.
- HPLC chromatogram is presented in Figure 5.
- Echinacea purpurea powder (Lot no. 01 K-3342) was placed into a ribbon blender. A 100 kg of 35% hydrogen peroxide solution was sprayed through nozzles within 2 minutes during the blending. After blending for 30 minutes at 50-60°C, a sample was taken for microbial analysis. The untreated material showed a TAC more than 100,000cfu/g, positive on E. coli and Salmonella, as well as yeast and mold more than 20,000cfu/g. After the treatment, the TAC of this powder was reduced to less than 1000cfu/g, yeast and mold were reduced to less than 1000cfu/g and E. coli and Salmonella were completely eliminated to non-detectable shown in Table 4.
- Chicoric acid and caffeoyal tartaric acid are two major components used as marks in the standardized Echinacea purpurea product on the marketplace.
- powder of Echinacea 01 J-3095
- the contents of chicoric acid and caffeoyal tartaric acid, before and after processing, are similar and the chromatogram profile are identical, indicating that the chemical compositions have not been significantly changed through this sterilization process.
- the HPLC chromatogram is presented in Figure 6.
- Caffeine is a major component used as mark in the standardized
- Sample ZG2-156B1 showed a TAC more than 1000cfu/g at room temperature process.
- Sample ZG2-156B2 showed a TAC less than 1000cfu/g when heat was applied.
- Echinacea purpurea powder Lot no. 011-3726
- five 50g of Echinacea purpurea powder were placed into five blenders and sprayed with different amount of 35% hydrogen peroxide solution, 0.5g, 1.0g, 1.5g, 2.0g, and 2.5g, respectively. After that, the five samples were heated at 90-100°C for 15 minutes to observe the effect of hydrogen peroxide on chemical profiles. No significant changes were observed in the contents of chicoric acid and caffeoyal tartaric acid in the powder before and after processing.
- Example 13 Five 100g of Cascara powder were sprayed with different amount of
- Echinacea purpurea powder was treated with different concentration of hydrogen peroxide solution, 1 %, 2%, 3%, 4%, and 5% of 35% hydrogen peroxide solution, and then heated at 90-100°C for 15 minutes. After above treatment, the samples were subject to microbial analyses and the result are listed in Table 19. Table 19
- Siberian ginseng powder (Lot No. 011-2599) was placed into a beaker. 56g of water was added into the beaker and heated at 90°C.
- Samples were taken after 1 , 2, and 3 hours, respectively. These samples were subjected to microbial testing and two samples which were heated for 1 and 2 hours showed TAC more than 1000cfu/g. The sample which was heated for 3 hours showed the TAC less than 1000cfu/g, but more than 10OOcfu/g after the sample was settled at room temperature for 4 days.
- Siberian ginseng powder Liberian ginseng powder (Lot No. 011-2599) was placed into a beaker and sprayed with 10g of hydrogen peroxide (35% solution). The sample was heated in an oven at 50-55°C for 0.5 hour. The sample was subjected to microbial testing and it showed the TAC less than 1000cfu/g.
- Siberian ginseng powder (Lot No. 011-2599) was placed into a 500 gallon mixing tank and sprayed with 25kg of hydrogen peroxide (35% solution). Add 130 gallons of water and mix for 30 minutes. Before spray drying, a sample was picked for microbial testing and it showed the TAC of more than 1000cfu/g but less than 5000. After spray drying at inlet temperature 450°F, the dried powder was tested and showed the TAC less than 1000cfu/g.
- Siberian ginseng powder (Lot No. 011-2599) was placed into a 500-gallon mixing tank and 130 gallons of water was added. The mixed material was heated at 80-90°C for 0.5 hour and then was spray dried. After spray drying at inlet temperature of 450°F, the dried powder was tested and it showed the TAC more than 1000cfu/g.
- Psyllium husk 1000kg was placed into a ribbon blender. Blended at 70-80°C for 10 minutes. A 50kg of 35% hydrogen peroxide solution was sprayed through nozzles within 2 minutes during the blending. After blending for 30 minutes at 70-80°C, a sample was taken and tested for the microbial analysis. After the sample was taken, another 50kg of 35%o hydrogen peroxide was sprayed through nozzles within 2 minutes during the blending. After blending for 30 minutes at 70-80°C, the second a sample was taken and tested for the microbial analysis. Microbial testing results were listed in the Table 21.
Abstract
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US46927 | 2002-01-15 | ||
US10/046,927 US6682697B2 (en) | 2002-01-15 | 2002-01-15 | Process for sterilization and disinfecting of agriculture and botanic products |
PCT/US2002/039373 WO2003059398A1 (fr) | 2002-01-15 | 2002-12-09 | Nouveau procede pour steriliser et desinfecter des produits agricoles et botaniques |
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EP1463534A1 true EP1463534A1 (fr) | 2004-10-06 |
EP1463534A4 EP1463534A4 (fr) | 2005-03-09 |
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EP02797250A Ceased EP1463534A4 (fr) | 2002-01-15 | 2002-12-09 | Nouveau procede pour steriliser et desinfecter des produits agricoles et botaniques |
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US (1) | US6682697B2 (fr) |
EP (1) | EP1463534A4 (fr) |
JP (1) | JP2005514169A (fr) |
AU (1) | AU2002362116A1 (fr) |
WO (1) | WO2003059398A1 (fr) |
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DE50100139D1 (de) * | 2001-01-26 | 2003-05-08 | Kreyenberg Heinrich | Verfahren zur Schädlingsbekämpfung bei Vorratswaren |
US7001631B2 (en) * | 2002-07-30 | 2006-02-21 | Steris Inc. | Low temperature sanitization of human pathogens from the surfaces of food and food packaging |
US20040056201A1 (en) * | 2002-09-19 | 2004-03-25 | Fink Ronald G. | Food surface sanitation hood |
US7160566B2 (en) * | 2003-02-07 | 2007-01-09 | Boc, Inc. | Food surface sanitation tunnel |
US20050268543A1 (en) * | 2004-06-03 | 2005-12-08 | Cargill, Inc. | Mobile furnace for heat treatment of agricultural materials in milling bins |
DE102004029803B4 (de) * | 2004-06-19 | 2007-01-11 | Khs Ag | Gefäßbehandlungsmaschine zur Sterilisation von Behältern mittels H2O2 |
US20060019002A1 (en) * | 2004-07-26 | 2006-01-26 | Harvest Food Co., Ltd. | Method for processing, storing and transporting garlic |
US20080226496A1 (en) * | 2005-03-18 | 2008-09-18 | Jacques Rivkine | Systemic Method For Proximity Hygiene and Device With Low-Temperature Sanitizing Chamber in Particular For Food Products |
JP2007252369A (ja) * | 2006-02-27 | 2007-10-04 | Ajinomoto Co Inc | 香辛料の殺菌方法 |
US7789027B1 (en) | 2007-10-12 | 2010-09-07 | Marshall Billy D | Soil treatment device |
JP4915958B2 (ja) * | 2008-03-26 | 2012-04-11 | パナソニック株式会社 | 空気清浄装置 |
CA2722477C (fr) * | 2008-05-26 | 2016-03-15 | Masahiro Kariyama | Procede de sterilisation de substances pulverulentes ou granulaires et appareil de sterilisation au moyen du procede |
US8361384B1 (en) | 2008-08-01 | 2013-01-29 | Aardvark Ip Holding, Llc | Water treatment device and methods of use |
US9187344B2 (en) | 2008-08-01 | 2015-11-17 | Silver Bullet Water Treatment Company, Llc | Water treatment device and methods of use |
MX2013004554A (es) | 2010-10-22 | 2014-02-06 | Agri Neo Inc | Actividad sinergistica de acido peracetico y al menos un inductor de sar para el control de patogenos dentro y sobre plantas en crecimiento. |
CA2803926C (fr) | 2011-04-12 | 2018-02-13 | Aardvark Ip Holding, Llc | Systemes et procedes de traitement d'eau utilisant le rayonnement uv |
JP5927986B2 (ja) * | 2012-02-28 | 2016-06-01 | 株式会社サタケ | 穀類の害虫駆除装置及び駆除方法 |
DE102012209435A1 (de) * | 2012-06-04 | 2013-12-05 | EVONTA - Service GmbH | Verfahren und Vorrichtung zur Desinfektion rieselfähiger Produkte, vorzugsweise Saatgut, mit Ultraviolettlicht (UV-Strahlung) |
RU2723077C2 (ru) * | 2015-04-29 | 2020-06-08 | СИНЕКСИС ЭлЭлСи | Способы использования газообразного очищенного пероксида водорода при производстве, транспортировании и хранении сельскохозяйственной продукции |
JP2018174944A (ja) * | 2018-08-22 | 2018-11-15 | 保土谷化学工業株式会社 | イネ種子の催芽時殺菌処理方法 |
RU205872U1 (ru) * | 2020-11-26 | 2021-08-11 | Роман Сергеевич Соколов | Шахтная зерносушилка с функцией обеззараживания зерна |
CN113277460B (zh) * | 2021-06-21 | 2023-01-10 | 新汉方(广东)科技有限公司 | 一种基于人工智能的低温无菌液体处理系统的工作方法 |
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- 2002-12-09 AU AU2002362116A patent/AU2002362116A1/en not_active Abandoned
- 2002-12-09 WO PCT/US2002/039373 patent/WO2003059398A1/fr active Application Filing
- 2002-12-09 EP EP02797250A patent/EP1463534A4/fr not_active Ceased
- 2002-12-09 JP JP2003559558A patent/JP2005514169A/ja active Pending
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US20030194347A1 (en) | 2003-10-16 |
AU2002362116A1 (en) | 2003-07-30 |
US6682697B2 (en) | 2004-01-27 |
EP1463534A4 (fr) | 2005-03-09 |
JP2005514169A (ja) | 2005-05-19 |
WO2003059398A1 (fr) | 2003-07-24 |
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