EP1458345A1 - Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole - Google Patents

Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole

Info

Publication number
EP1458345A1
EP1458345A1 EP02795197A EP02795197A EP1458345A1 EP 1458345 A1 EP1458345 A1 EP 1458345A1 EP 02795197 A EP02795197 A EP 02795197A EP 02795197 A EP02795197 A EP 02795197A EP 1458345 A1 EP1458345 A1 EP 1458345A1
Authority
EP
European Patent Office
Prior art keywords
preparation according
preparations
cosmetic
filter
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP02795197A
Other languages
German (de)
English (en)
Inventor
Anja Göppel
Jens Schulz
Eckhard Klette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP1458345A1 publication Critical patent/EP1458345A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • Cosmetic and dermatological light protection formulations containing water-soluble UV filter substances and benzoxazole derivatives containing water-soluble UV filter substances and benzoxazole derivatives
  • the present invention relates to cosmetic and dermatological light protection preparations, in particular it relates to cosmetic and dermatological formulations with increased UV-A protection.
  • the damaging effect of the ultraviolet part of solar radiation on the skin is generally known. Depending on their wavelength, the rays have different effects on the skin organ:
  • UV-C radiation with a wavelength between 100 and 280 nm is absorbed by the ozone layer in the earth's atmosphere and is therefore not found in the solar spectrum. It is therefore of no physiological importance when sunbathing.
  • UV-B range is between 290 nm and 320 nm. UV-B rays are essential for long-lasting tanning of the skin, but can also cause erythema, simple sunburn or even more or less severe burns. Chronic light damage, photodermatosis and herpes solaris can also be caused by UV-B radiation.
  • UV-A radiation with a wavelength between 320 nm and 400 nm only a negligible biological ⁇ specific effect and in that, accordingly, the UV-B rays responsible for most of photodamage in human skin are.
  • UV-A radiation is pho- todynamic, especially phototoxic reactions and chronic changes in the skin is far more dangerous than UV-B radiation.
  • the damaging influence of UV-B radiation can also be intensified by UV-A radiation.
  • UV-A radiation About 90% of the ultraviolet radiation reaching the earth consists of UV-A rays. While UV-B radiation varies greatly depending on numerous factors (eg time of year and time of day or latitude), UV-A radiation remains relatively constant day by day, irrespective of the time of year, day or geographical factors , At the same time, the majority of UV-A radiation penetrates the living epidermis, while around 70% of UV-B rays are retained by the horny layer.
  • the ultraviolet rays can be attenuated by two effects: on the one hand by reflection and scattering of the rays on the surface of powdery solids (physical light protection) and on the other hand by absorption of chemical substances (chemical light protection). It differs depending on which wavelength range is absorbed between UV-B filters (absorption range 280 to 320 nm), UV-A filters (absorption range 320 to 400 nm) and broadband filters (absorption range 290 to approx. 380 nm).
  • UV-B filters are e.g. B. derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid, salicylic acid, benophenone and also 2-phenylbenzimidazole.
  • UV-A filter substances are certain water-soluble, sulfonated UV filter substances, such as. B. phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts.
  • This group of broadband filters includes, for example, asymmetrically substituted s-triazine compounds, such as. B. 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] phenyl ⁇ -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: bis -Ethylhexyloxylphenol methoxy-phenyl triazine), certain benzophenones, such as. B.
  • the light absorption behavior of light protection filter substances is very well known and documented, especially since in most industrialized countries there are positive lists for the use of such substances, which apply very strict standards to the documentation. Since not only the position of the absorption maximum, but above all the absorption range is important for the characterization of a filter substance, absorption spectra of each substance are recorded. For the dosage of the substances in the finished formulations, however, the extinction values can at best be an orientation offer, because interactions with ingredients of the skin or the skin surface itself can cause uncertainties. Furthermore, it is generally difficult to estimate in advance how evenly and in what layer thickness the filter substance is distributed in and on the hom layer of the skin.
  • the IPD method (IPD ⁇ immediate pigment darkening) is usually used to test UV-A protection. Similar to the determination of the sun protection factor, a value is determined that indicates how much longer the skin protected with the light protection agent can be irradiated with UV-A radiation until the same pigmentation occurs as for the unprotected skin.
  • UV filter substances which are advantageous per se are water-soluble, so that they are only of limited suitability for producing waterproof sun protection products.
  • a further object of the present invention was therefore to find waterproof cosmetic or dermatological light protection preparations which are distinguished in particular by high UV-A protection.
  • cosmetic or dermatological preparations which have a light protection effect, characterized in that they (a) contain at least one water-soluble UV filter substance and (b) at least one benzoxazole derivative would remedy the disadvantages of the prior art ,
  • the preparations according to the invention are extremely satisfactory preparations in every respect, which are not limited to a restricted selection of raw materials. Accordingly, they are particularly suitable to serve as the basis for forms of preparation with a variety of uses.
  • the preparations according to the invention show very good sensory and cosmetic properties, such as, for example, the distributability on the skin or the ability to be absorbed into the skin, and are also notable for very good light protection effectiveness, an extremely high UV-A protection performance and excellent skin compatibility at the same time excellent skin care data.
  • the invention therefore also relates to cosmetic or dermatological preparations which have a light protection effect, characterized in that they contain synergistic combinations of substances
  • (b) contain at least one benzoxazole derivative, the UV protection, in particular the UV-A protection, of these preparations being increased disproportionately.
  • the combinations of substances according to the invention are surprisingly synergistic, that is to say superadditive in relation to the individual components. They are photostable without further additives and show a surprisingly high protection performance in the UV-A range.
  • the preparations according to the invention are furthermore distinguished by an astonishingly high water resistance.
  • the invention therefore also relates to waterproof light-protective cosmetic or dermatological preparations, characterized in that they
  • (b) contain at least one benzoxazole derivative.
  • R 1 , R 2 and R 3 are independently selected from the group of branched or unbranched, saturated or unsaturated alkyl radicals having 1 to 10 carbon atoms. It is particularly advantageous according to the invention to choose the radicals R and R equally, in particular from the group of the branched alkyl radicals having 3 to 5 carbon atoms. It is furthermore particularly advantageous for the purposes of the present invention if R 3 is an unbranched or branched alkyl radical having 8 carbon atoms, in particular the 2-ethylhexyl radical.
  • Benzoxazole derivative which is particularly preferred according to the invention is 2,4-bis- [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) -imino] -6- (2-ethylhexyl) -imino-1, 3,5-triazine with CAS No. 288254-16-0, which is characterized by the structural formula
  • ChbCHs and is available from 3V Sigma under the trade name Uvasorb® K2A.
  • the benzoxazole derivative or derivatives are advantageously present in dissolved form in the cosmetic preparations according to the invention. However, it may also be advantageous if the benzoxazole derivative or derivatives in pigmentary, ie. H. undissolved form - for example in particle sizes from 10 nm to 300 nm.
  • the total amount of one or more benzoxazole derivatives in the finished cosmetic or dermatological preparations is advantageously chosen in each case from the range from 0.01% by weight to 20% by weight, preferably from 0.1 to 10% by weight on the total weight of the preparations.
  • Advantageous water-soluble UV filter substances in the sense of the present invention are sulfonated UV filters, in particular:
  • Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid which is distinguished by the following structure: and their salts, especially the corresponding sodium, potassium or triethanolammonium salts, in particular the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis sodium salt •
  • Disodium Phenyl Dibenzimidazole Tetrasulfonate (CAS no .: 180898-37-7), which is available, for example, from Haarmann & Reimer under the trade name Neo Heliopan AP.
  • 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene also: 3,3 '- (1,4-phenylenedimethylene) -bis- (7, 7-dimethyl-2-oxobicyclo- [2.2.1Jhept-1-y! Methane sulfonic acid) and its salts (especially the corresponding 10-sulfato compounds, especially the corresponding sodium, potassium or triethanolammonium salt), the is also referred to as benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid) and is characterized by the following structure:
  • Benzene-1,4-di (2-oxo-3-bomylidenemethyl-10-sulfonic acid) has the INCI name Terephthalidene Dicampher Sulfonic Acid (CAS No. 90457-82-2) and is for example under the trade name Mexoryl SX available from Chimex.
  • Further advantageous water-soluble UV-B and / or Breitba ⁇ d filter substances in the sense of the present invention are, for.
  • the total amount of one or more water-soluble UV filter substances in the finished cosmetic or dermatological preparations is advantageously chosen from the range from 0.01% by weight to 20% by weight, preferably from 0.1 to 10% by weight based on the total weight of the preparations.
  • weight ratios of the benzoxazole derivative (s) to the water-soluble UV filter substance (s) as 30: 1 to 1:30, preferably as 10: 1 to 1:10, particularly as 5: 1 to 1: 5 to choose.
  • the preparations can preferably contain, in addition to one or more oil phases, one or more water phases and, for example, in the form of W / O, O / W, W / O / W or O / W / O emulsions .
  • Such formulations may preferably also be microemulsions, sticks, foams (so-called mousse), solid emulsions (i.e. emulsions stabilized by solids, e.g. Pickering emulsions), sprayable emulsions or hydrodispersions.
  • the preparations can advantageously also be oil-free and / or aqueous / alcoholic solutions.
  • Sprayable emulsions especially microemulsions
  • Sprayable O / W emulsions in particular O W microemulsions, are particularly advantageous for the purposes of the present invention.
  • the droplet diameters of the usual “simple”, ie non-multiple emulsions are in the range from approx. 1 ⁇ m to approx. 50 ⁇ m.
  • Such “macroemulsions” are colored milky white and opaque without further coloring additives.
  • Finer “macroemulsions”, whose droplet diameters are in the range from approximately 0.5 ⁇ m to approximately 1 ⁇ m, are again blue-white in color and opaque, without coloring additives.
  • Such “macroemulsions” usually have a high viscosity.
  • the droplet diameter of microemulsions in the context of the present invention is in the range from about 50 to about 500 nm.
  • Such microemulsions are colored bluish white to translucent and mostly of low viscosity.
  • the viscosity of many O / W type micro-emulsions is comparable to that of water.
  • microemulsions are used as cosmetics corresponding products characterized by high cosmetic elegance.
  • O / W microemulsions which are obtainable with the aid of so-called phase inversion temperature technology and contain at least one emulsifier (emulsifier A), which is selected from the group of emulsifiers with the following properties, are particularly advantageous according to the invention:
  • Advantageous emulsifiers A are e.g. B. polyethoxylated fatty acids (PEG-100 stearate, PEG-20 stearate, PEG-150 Laurath, PEG-8 distearate and the like) and / or polyethoxylated fatty alcohols (Cetearath-12, Cetearath-20, Isoceteth-20, Beheneth-20, Lau - reth-9 etc.) and / or alkyl polyglycosides (cetearyl glycoside, stearyl glycoside, palmityl glycoside etc.).
  • PEG-100 stearate PEG-20 stearate, PEG-150 Laurath, PEG-8 distearate and the like
  • polyethoxylated fatty alcohols Cetearath-12, Cetearath-20, Isoceteth-20, Beheneth-20, Lau - reth-9 etc.
  • alkyl polyglycosides cetearyl glycoside,
  • O / W emulsions in particular O / W microemulsions
  • the size of the oil droplets being essentially determined by the concentration of the emulsifier (s) used, such that a higher one Emulsifier concentration causes smaller droplets and lower emulsifier concentration leads to larger droplets.
  • the droplet sizes are usually between 20 and 500 nm.
  • alkyl methicon copolyols and / or alkyl dimethicone copolyols in particular cetyl dimethicone copolyol, lauryl methicone copolyol
  • W / O emulsifiers such as sorbitan stearate, glyceryl stearate, glycerol stearate, sorbitan oleate, lecithin, glyceryl isostearate 3-polygly , Polyglyceryl-3 diisostearate, PEG-7 hydrogenated castor oil, polyglyceryl-4-isostearate, acrylate / C ⁇ 0.
  • Further advantageous sprayable O / W emulsions for the purposes of the present invention are low-viscosity cosmetic or dermatological hydrodispersions which contain at least one oil phase and at least one water phase, the preparation being stabilized by at least one gel former and not necessarily having to contain emulsifiers, but one or can contain several emulsifiers.
  • Advantageous gel formers for such preparations are, for example, copolymers of do- 30 alkyl acrylates and one or more monomers of acrylic acid, methacrylic acid or their esters.
  • the INCI name for such compounds is "Acrylates / C 10-30 Alkyl Acrylate Crosspolymer”.
  • the Pemulen® types TR 1, TR 2 and TRZ from Goodrich (Noveon) are particularly advantageous.
  • Carbopole are also advantageous gel formers for such preparations.
  • Carbopols are polymers of acrylic acid, especially also acrylate-alkyl acrylate copolymers.
  • Advantageous carbopoles are, for example, types 907, 910, 934, 940, 941, 951, 954, 980, 981, 1342, 1382, 2984 and 5984.
  • ETD types 2020, 2050 and Carbopol Ultrez 10 are also further advantageous gel formers for such Preparations are xanthan gum, cellulose derivatives and locust bean gum.
  • Possible (optional) emulsifiers which can be used are ethoxylated fatty alcohols or ethoxylated fatty acids (in particular PEG-100 stearate, ceteareth-20) and / or other nonionic surface-active substances.
  • the very low viscosity to sprayable emulsions can also be W / O or water-in-silicone oil (W / S) emulsions.
  • Such preparations also contain at least 20% by weight of lipids, the lipid phase advantageously also containing silicone oils or even consisting entirely of such oils.
  • the silicone emulsifier (s) can advantageously be chosen from the group of alkyl methicon copolyols and / or alkyl dimethicone copolyols (eg dimethicone copolyols, which are available from Goldschmidt AG under the trade names ABIL® B 8842, ABIL® B 8843, ABIL® B 8847 , ABIL® B 8851, ABIL® B 8852, ABIL® B 8863, ABIL® B 8873 and ABIL® B 88183 are sold, cetyl dimethicone copolyol [Goldschmidt AG / ABIL® EM 90], cyclomethicone dimethicone copolyol [Goldschmidt AG / ABIL® EM 97 ], Lauryl methicone copolyol [Dow Corning Ltd./Dow Corning® 5200 Formulation Aid], octyl dimethi
  • the one or more W / O emulsifiers with an HLB value ⁇ 7 can advantageously be selected from the following group: sorbitan stearate, sorbitan oleate, lecithin, glyceryl alcoholate, lanolin, hydrogenated castor oil, glyceryl isostearate, polyglyceryl-3-oleate, pentaerythrithyl isostearate, methylglucose dioleate Mixture with hydroxystearate and beeswax, PEG-7 hydrogenated castor oil, polyglyceryl 4-isostearate, hexyl laurate, acrylate / C 10- 3o-alkyl acrylate cross-polymer, sorbitan isostearate, poloxamer 101, polyglyceryl-2-dipolyhydroxy stearate, di-glyceryl-3-di , PEG-30-dipolyhydroxystearate, diisostearoyl-polyglyceryl-3
  • the O / W emulsifier (s) with an HLB value> 10 can advantageously be selected from the following group: glyceryl stearate in a mixture with ceteareth-20, ceteareth-25, ceteareth-6 in a mixture with stearyl alcohol, cetylstearyl alcohol in a mixture with PEG-40 Castor oil and sodium cetyl stearyl sulfate, triceteareth-4 phosphate, glyceryl stearate, sodium cetyl stearyl sulfate, lecithin trilaureth-4 phosphate, laureth-4 phosphate, stearic acid, Propylene glycol stearate SE, PEG-9 stearate, PEG-20 stearate, PEG-30 stearate, PEG-40 stearate, PEG-100 stearate, Ceteth-2, Ceteth-20, Polysorbate-20, Polysorbate-60, poly- sorbate-65, polysorbate-100,
  • Aqueous-alcoholic solutions are also advantageous. They can contain from 0% by weight to 90% by weight of ethanol.
  • aqueous alcoholic solutions can advantageously also contain solubilizers, such as. B. PEG-40 or PEG-60 hydrogenated castor oil.
  • the preparations according to the invention can advantageously also be used as cosmetic or dermatological impregnation solutions, with which in particular water-insoluble substrates - such as, for. B. woven or non-woven cloths - are moistened.
  • Such impregnation solutions are preferably low-viscosity, in particular sprayable (such as, for example, PIT emulsions, hydrodispersions, W / O emulsions, oils, aqueous solutions, etc.) and preferably have a viscosity of less than 2000 mPa-s, in particular less than 1,500 mPa-s (measuring device: Haake Viscotester VT-02 at 25 ° C).
  • sprayable such as, for example, PIT emulsions, hydrodispersions, W / O emulsions, oils, aqueous solutions, etc.
  • a viscosity of less than 2000 mPa-s, in particular less than 1,500 mPa-s
  • foams Self-foaming, foam-like, post-foaming or foamable cosmetic and dermatological preparations are also particularly advantageous for the purposes of the present invention.
  • “Self-foaming”, “foam-like”, “post-foaming” or “foamable” are understood to mean preparations from which foams - be it already during the manufacturing process, be it in use by the consumer or in some other way - by entering one or several gases can be produced in principle.
  • the gas bubbles are (arbitrarily) distributed in one (or more) liquid phase (s), the (foamed) preparations not necessarily having to have the appearance of a foam macroscopically.
  • (Foamed) cosmetic or dermatological preparations according to the invention (hereinafter also referred to simply as foams for the sake of simplicity) can, for. B. represent macroscopically visible dispersed systems from gases dispersed in liquids.
  • foam character can only become visible under a (light) microscope, for example.
  • foams according to the invention - especially when the gas bubbles are too small to be recognized under a light microscope - can also be recognized from the large increase in volume of the system.
  • such preparations advantageously contain an emulsifier system which consists of
  • the emulsifier (s) A are preferably selected from the group of the fatty acids which are wholly or partly with customary alkalis (such as sodium and / or potassium hydroxide, sodium and / or potassium carbonate and mono- and / or triethanolamine) are neutralized.
  • customary alkalis such as sodium and / or potassium hydroxide, sodium and / or potassium carbonate and mono- and / or triethanolamine
  • stearic acid and stearates, isostearic acid and isostearates, palmitic acid and palmitates, and myristic acid and myristates are particularly advantageous.
  • the emulsifier (s) B are preferably selected from the following group: PEG-9 stearate, PEG-8 distearate, PEG-20 stearate, PEG-8 stearate, PEG-8 oleate, PEG-25 glyceryl trioleate, PEG- 40-sorbitan lanolate, PEG-15 glyceryl ricinoleate, PEG-20 glyceryl stearate, PEG-20 glyceryl isostearate, PEG-20 glyceryl oleate, PEG-20 stearate, PEG-20 methylglucose sesquistearate, PEG-30 glyceryl isostearate, PEG Glyceryl laurate, PEG-30 stearate, PEG-30 glyceryl stearate, PEG-40 stearate, PEG-30 glyceryl laurate, PEG-50 stearate, PEG-100 stearate, PEG-150 laurate.
  • the co-emulsifier (s) C are preferably selected from the following group: behenyl alcohol (C 22 H 45 OH), cetearyl alcohol [a mixture of cetyl alcohol (C 16 H 33 OH) and stearyl alcohol (C 18 H 37 OH)], lanolin alcohols (Wool wax alcohols, which represent the unsaponifiable alcohol fraction of the wool wax, which is obtained after the saponification of wool wax). Cetyl and cetylstearyl alcohol are particularly preferred.
  • weight ratios of emulsifier A to emulsifier B to coemulsifier C (A: B: C) as a: b: c, where a, b and c independently of one another are rational numbers from 1 to 5, preferably from 1 can represent up to 3.
  • a weight ratio of approximately 1: 1: 1 is particularly preferred.
  • the total amount of emulsifiers A and B and of coemulsifier C is advantageous for the total amount of emulsifiers A and B and of coemulsifier C to be in the range from 2 to 20% by weight, advantageously from 5 to 15% by weight, in particular from 7 to 13% by weight. %, each based on the total weight of the formulation.
  • cosmetic or dermatological preparations which can be stabilized only by finely divided solid particles are also particularly advantageous. are listed.
  • Such “emulsifier-free” emulsions are also referred to as Pickering emulsions.
  • the solid material In Pickering emulsions, the solid material accumulates at the oil / water phase boundary in the form of a layer, which prevents the disperse phases from converging.
  • the surface properties of the solid particles which should show both hydrophilic and lipophilic properties, are of particular importance.
  • the stabilizing solid particles can advantageously also be surface-treated ("coated"), whereby an amphiphilic character of these solid particles should be formed or retained.
  • the surface treatment can consist in that the solid particles are treated with a thin hydrophobic or hydrophilic layer are provided.
  • the average particle diameter of the microfine solid particles used as a stabilizer is preferably chosen to be less than 100 ⁇ m, particularly advantageously less than 50 ⁇ m. It is essentially irrelevant in which form (platelets, rods, beads, etc.) or modification the solid particles used are present.
  • microfine solid particles are preferably selected from the group of the amphiphilic metal oxide pigments. The following are particularly advantageous:
  • Titanium dioxides (coated and uncoated): e.g. B. Eusolex T-2000 from Merck, titanium dioxide MT-100 Z from Tayca Corporation. B. Z-Cote and Z-Cote HP1 from BASF AG, MZ-300, MZ-500 and MZ-505M from Tayca Corporation
  • microfine solid particles are selected from the following group: boron nitrides, starch derivatives (tapioca starch, sodium com starch octynyl succinate etc.), talc, latex particles.
  • the solid-stabilized emulsions contain significantly less than 0.5% by weight of one or more emulsifiers or are even completely emulsifier-free. pencils
  • Common base materials for stick-like preparations are, for example, liquid oils (such as paraffin oils, castor oil, isopropyl myristate, C 12-15 alkyl benzoate), semi-solid components (e.g. petroleum jelly, lanolin), solid components (e.g. beeswax, ceresin) and microcrystalline waxes or ozokerite) and / or high-melting waxes (eg carnauba wax, candelilla wax).
  • liquid oils such as paraffin oils, castor oil, isopropyl myristate, C 12-15 alkyl benzoate
  • semi-solid components e.g. petroleum jelly, lanolin
  • solid components e.g. beeswax, ceresin
  • high-melting waxes eg carnauba wax, candelilla wax.
  • Water-containing stick-like preparations are also known per se, although these can also be in the form of W / O e
  • the cosmetic or dermatological light protection formulations according to the invention can be composed as usual and can be used for cosmetic or dermatological light protection, also for the treatment, care and cleaning of the skin and / or hair and as a make-up product in decorative cosmetics.
  • cosmetic or topical dermatological compositions can be used for the purposes of the present invention, for example as skin protection cream, cleansing milk, day or night cream, etc. It may be possible and advantageous to use the compositions according to the invention as the basis for pharmaceutical formulations.
  • the cosmetic and dermatological preparations are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics.
  • the cosmetic and dermatological preparations according to the invention can contain cosmetic auxiliaries as are usually used in such preparations, e.g. As preservatives, preservation aids, complexing agents, bactericides, perfumes, substances to prevent or increase foaming, dyes, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances, fillers which improve the feeling on the skin, fats, oils, waxes or other conventional constituents of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.
  • cosmetic auxiliaries as are usually used in such preparations, e.g. As preservatives, preservation aids, complexing agents, bactericides, perfumes, substances to prevent or increase foaming, dyes, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances, fillers which improve the feeling on the skin, fats, oils, waxes or other conventional constituents of a
  • Advantageous preservatives for the purposes of the present invention are, for example, formaldehyde releasers (such as, for example, DMDM hydantoin, which is available, for example, from Lonza under the trade name Glydant TM), iodopropyl butyl carbamate (for example those under the trade names Glycacil-L , Glycacil-S available from Lonza and / or Dekaben LMB from Jan Dekker), parabens (ie alkyl p-hydroxybenzoate, such as methyl, ethyl, propyl and / or butyl paraben), phenoxyethanol, ethanol, Benzoic acid and the like.
  • the preservation system usually also advantageously includes preservation aids, such as, for example, octoxyglycerol, glycine soya, etc.
  • Advantageous complexing agents for the purposes of the present invention are, for example, EDTA, [S, S] -ethylenediamine disuccinate (EDDS), which is available, for example, from Octel under the trade name Octaquest, pentasodium-ethylenediaminetetramethylenephosphonate, which, for. B. is available under the trade name Dequest 2046 from Monsanto and / or iminodisuccinic acid, which u. a. is firmly available from Bayer AG under the trade names Iminodisuccinat VP OC 370 (approx. 30% solution) and Baypure CX 100.
  • EDDS EDTA
  • [S, S] -ethylenediamine disuccinate (EDDS) which is available, for example, from Octel under the trade name Octaquest
  • pentasodium-ethylenediaminetetramethylenephosphonate which, for. B.
  • Dequest 2046 from Monsanto and / or iminodis
  • compositions are also obtained if antioxidants are used as additives or active ingredients.
  • the preparations advantageously contain one or more antioxidants. All of the antioxidants suitable or customary for cosmetic and / or dermatological applications can be used as inexpensive, but nevertheless optional, antioxidants.
  • water-soluble antioxidants such as vitamins, e.g. B. ascorbic acid and its derivatives.
  • Preferred antioxidants are also vitamin E and its derivatives and vitamin A and its derivatives.
  • the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 0.1 to 10% by weight, based on the total weight the preparation.
  • vitamin E and / or its derivatives represent the antioxidant (s)
  • vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to add their respective concentrations in the range from 0.001 to 10% by weight, based on the total weight of the formulation choose.
  • the cosmetic preparations according to the present invention contain cosmetic or dermatological active ingredients, preferred active ingredients being antioxidants which can protect the skin from oxidative stress.
  • active ingredients in the sense of the present invention are natural active ingredients and / or their derivatives, such as.
  • Recipes according to the invention which, for. B. known anti-wrinkle agents such as flavone glycosides (especially ⁇ -glycosylrutin), coenzyme Q10, vitamin E and / or derivatives and the like, are particularly advantageous for the prophylaxis and treatment of cosmetic or dermatological skin changes such as z. B. occur with skin aging (such as dryness, roughness and formation of dry wrinkles, itching, reduced regreasing (e.g. after washing), visible vasodilation (telangiectasias, cuperosis), flaccidity and training of wrinkles and fine lines, local hyper-, hypo- and incorrect pigmentations (e.g. age spots), increased susceptibility to mechanical stress (e.g. cracking) and the like). They are also advantageous against the appearance of dry or rough skin.
  • the water phase of the preparations according to the invention can advantageously contain conventional cosmetic auxiliaries, such as, for example, alcohols, in particular those having a low C number, preferably ethanol and / or isopropanol, diols or polyols having a low C number, and their ethers, preferably propylene glycol, glycerol, butylene glycol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analog products, polymers, foam stabilizers, electrolytes and in particular one or more thickeners, which one or more can advantageously be selected from the group Silicon dioxide, aluminum silicates, polysaccharides or their derivatives, e.g.
  • conventional cosmetic auxiliaries such as, for example, alcohols, in particular those having a low C number, preferably ethanol and / or isopropanol
  • B. hyaluronic acid, xanthan gum, hydroxypropylmethyl cellulose particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopoles [from Bf. Goodrich], for example carbopoles of types 980, 981, 1382, 2984, 5984, ETD 2020, ETD 2050, Ultrez 10, each individually or in combination.
  • the preparations according to the invention can also advantageously contain self-tanning substances, such as, for example, dihydroxyacteon and / or melanin derivatives in concentrations of 1% by weight to 8% by weight, based on the total weight of the preparation.
  • self-tanning substances such as, for example, dihydroxyacteon and / or melanin derivatives in concentrations of 1% by weight to 8% by weight, based on the total weight of the preparation.
  • the preparations according to the invention can also advantageously contain repellents for protection against mosquitoes, ticks and spiders and the like.
  • repellents for protection against mosquitoes, ticks and spiders and the like.
  • B N, N-diethyl-3-methylbenzamide (trade name: Meta-delphene, "DEET"), dimethyl phthalate (trade name: Palatinol M, DMP) and in particular 3- (Nn-butyl-N-acetylamino) - ethyl propionate (available under the trade name Insekt Repellent® 3535 from Merck)
  • the repellents can be used both individually and in combination.
  • Moisturizers are substances or mixtures of substances that give cosmetic or dermatological preparations the property of reducing the release of moisture from the horny layer (also called trans-epiderma! Water loss (TEWL)) and / or hydration after application or distribution on the skin surface to influence the horny layer positively.
  • TEWL trans-epiderma! Water loss
  • moisturizers for the purposes of the present invention are, for example, glycerin, lactic acid and / or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccaride gum-1, glycine soya, ethylhexyloxyglycerol, pyrrolidone carboxylic acid and urea.
  • polymeric moisturizers from the group of water-soluble and / or water-swellable and / or water-gelable polysaccharides.
  • hyaluronic acid chitosan and / or a fucose-rich polysaccharide
  • chitosan and / or a fucose-rich polysaccharide
  • Fucogel®1000 from the company SOLABIA S.A. is available.
  • Moisturizers can also advantageously be used as anti-wrinkle active ingredients for the prophylaxis and treatment of cosmetic or dermatological skin changes, such as those described for. B. occur in skin aging, are used.
  • the cosmetic or dermatological preparations according to the invention can furthermore advantageously, although not necessarily, contain fillers which, for. B. further improve the sensory and cosmetic properties of the formulations and, for example, cause or intensify a velvety or silky feeling on the skin.
  • Advantageous fillers for the purposes of the present invention are starch and starch derivatives (such as tapioca starch, distarch phosphate, aluminum or sodium starch, octenyl succinate and the like), pigments which have neither mainly UV filter nor coloring effects (such as e.g. B. boron nitride etc.) and / or Aerosile ® (CAS No. 7631-86-9).
  • the oil phase of the formulations according to the invention is advantageously selected from the group of polar oils, for example from the group of lecithins and fatty acid triglycerides, in particular the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12 to 18 carbon atoms.
  • the fatty acid triglycerides can for example be advantageously selected from the group of synthetic, semi-synthetic and natural oils, such as. B.
  • cocoglyceride olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, Palm oil, coconut oil, castor oil, wheat germ oil, grape seed oil, safflower oil, evening primrose oil, macadamia nut oil and the like.
  • z. B natural waxes of animal and vegetable origin, such as beeswax and other insect waxes, and berry wax, shea butter and / or lanolin (wool wax).
  • further advantageous polar oil components can also be selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C atoms and from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C atoms.
  • ester oils can then advantageously be selected from the group octyl palmitate, octyl co-coat, octyl isostearate, octyl dodeceyl myristate, octyl dodecanol, cetearyl isononanoate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-stonolate, n-stonolate, n-stonyl-n-stonate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, stearyl heptanoate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate
  • the oil phase can advantageously be selected from the group of dialkyl ethers and dialkyl carbonates.
  • Advantageous oil components are also e.g. B. butyl octyl salicylate (for example that available under the Hallbrite BHB trade name from CP Hall), hexadecyl benzoate and butyl octyl benzoate and mixtures thereof (Hallstar AB) and / or diethyl hexyl naphthalate (Hallbrite TQ or Corapan TQ from H&R).
  • B. butyl octyl salicylate for example that available under the Hallbrite BHB trade name from CP Hall
  • hexadecyl benzoate and butyl octyl benzoate and mixtures thereof Hallstar AB
  • Hallbrite TQ or Corapan TQ from H&R diethyl hexyl naphthalate
  • the oil phase can also advantageously also contain non-polar oils, for example those selected from the group of branched and unbranched hydrocarbons and waxes, in particular mineral oil, petroleum jelly (petrolatum), paraffin oil, squalane and squalene, polyolefins, hydrogenated polyisobutenes and isohexa- decane.
  • non-polar oils for example those selected from the group of branched and unbranched hydrocarbons and waxes, in particular mineral oil, petroleum jelly (petrolatum), paraffin oil, squalane and squalene, polyolefins, hydrogenated polyisobutenes and isohexa- decane.
  • polyolefins polydecenes are the preferred substances.
  • the oil phase can advantageously also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
  • Silicone oils are high-molecular synthetic polymeric compounds in which silicon atoms are linked in a chain and / or network-like manner via oxygen atoms and the remaining valences of silicon by hydrocarbon residues (mostly methyl, more rarely ethyl, propyl, phenyl) Groups, etc.) are saturated.
  • the silicone oils are systematically referred to as polyorganosiloxanes.
  • the methyl-substituted polyorganosiloxanes which are the most important compounds of this group in terms of quantity and are characterized by the following structural formula
  • I CH 3 are also known as polydimethylsiloxane or dimethicone (INCI). Dimethicone is available in different chain lengths or with different molecular weights.
  • Particularly advantageous polyorganosiloxanes for the purposes of the present invention are, for example, dimethylpolysiloxanes [poly (dimethylsiloxane)], which are available, for example, under the trade names Abil 10 to 10,000 from Th. Goldschmidt.
  • phenylmethylpolysiloxanes INCI: phenyl dimethicone, phenyl trimethicone
  • cyclic silicones octamethylcyclotetrasiloxane or decamethylcyclopentasiloxane
  • amino-modified silicones INCI: amodimethicone and silicone.
  • polysiloxane-polyalkylene copolymers (INCI: stearyl dimethicone and cetyl dimethicone) and dialkoxydimethyl polysiloxanes (stearoxy dimethicone and behenoxy stearyl dimethicone), which are available as different Abil-Wax types from Th. Goldschmidt.
  • other silicone oils can also be used advantageously for the purposes of the present invention, for example cetyldimethicone, hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • the preparations according to the invention can also advantageously contain one or more substances from the following group of siloxane elastomers, for example in order to increase the water resistance and / or the sun protection factor of the products:
  • Siloxane elastomers which contain the units R 2 SiO and RSiO ⁇ , 5 and / or R 3 SiO 0
  • Siloxane elastomers which are insoluble and swellable in silicone oil and which can be obtained by the addition reaction of an organopolysiloxane (1) which contains silicon-bonded hydrogen with an organopolysiloxane (2) which contains unsaturated aliphatic groups, the quantitative parts used be chosen so that the amount of hydrogen of the organopolysiloxane (1) or the unsaturated aliphatic groups of the organopolysiloxane (2) • is in the range from 1 to 20 mol% when the organopolysiloxane is not cyclic and in the range from 1 to 50 mol% when the organopolysiloxane is cyclic.
  • the siloxane elastomer (s) are in the form of spherical powders or in the form of gels.
  • siloxane elastomers in the form of spherical powder according to the invention are those with the INCI name Dimethicone / Vinyl Dimethicone Crosspolymer, for example that available from DOW CORNING under the trade names DOW CORNING 9506 Powder.
  • siloxane elastomer is used in combination with oils from hydrocarbons of animal and / or vegetable origin, synthetic oils, synthetic esters, synthetic ethers or mixtures thereof.
  • siloxane elastomer is used in combination with unbranched silicone oils which are liquid or pasty at room temperature or cyclic silicone oils or mixtures thereof.
  • Organopolysiloxane elastomers with the INCI name Dimethicone / Polysilicone-11 are particularly advantageous, especially the Gransil types GCM, GCM-5, DMG-6, CSE Gel, PM-Gel, LTX, ININ available from Grant Industries Inc. Gel, AM-18 gel and / or DMCM-5.
  • the siloxane elastomer is used in the form of a gel composed of siloxane elastomer and a lipid phase, the content of the siloxane elastomer in the gel being 1 to 80% by weight, preferably 0.1 to 60% by weight , each based on the total weight of the gel.
  • the total amount of the siloxane elastomers (active content) is in the range from 0.01 to 10% by weight, advantageously from 0.1 to 5% by weight, in each case based on the total weight of the Wording to choose.
  • the cosmetic and dermatological preparations according to the invention can contain dyes and / or color pigments, especially if they are in the form of decorative ratative cosmetics are available.
  • the dyes and pigments can be selected from the corresponding positive list in the Cosmetics Ordinance or the EC list of cosmetic colorants. In most cases, they are identical to the colorants approved for food.
  • Advantageous color pigments are, for example, titanium dioxide, mica, iron oxides (for example Fe 2 O 3 , Fe 3 O 4 , FeO (OH)) and / or tin oxide.
  • Advantageous dyes are, for example, carmine, Berlin blue, chrome oxide green, ultramarine blue and / or manganese violet. It is particularly advantageous to choose the dyes and / or color pigments from the Rowe Color Index, 3rd edition, Society of Dyers and Colorists, Bradford, England, 1971.
  • the formulations according to the invention are in the form of products which are used on the face, it is advantageous to choose one or more substances from the following group as the dye: 2,4-dihydroxyazobenzene, 1- (2'-chloro-4'- nitro-1'-phenylazo) -2-hydroxynaphthalene, ceres red, 2- (sulfo-1-naphthylazo) -1-naphthol-4-sulfonic acid, calcium salt of 2-hydroxy-1, 2'-azonaphthalene-1'- sulfonic acid, calcium and barium salts of 1- (2-sulfo-4-methyl-1-phenylazo) -2-naphthylcarboxylic acid, calcium salt of 1- (2-sulfo-1-naphthylazo) -2-hydroxynaphthalene-3-carboxylic acid, aluminum salt 1- (4-sulfo-1-phenylazo) -2-naphthol-6-sulfonic acid, aluminum
  • oil-soluble natural dyes such as. B. paprika extracts, ß-carotene or cochineal.
  • Formulations containing pearlescent pigments are also advantageous for the purposes of the present invention.
  • the types of pearlescent pigments listed below are particularly preferred: 1. Natural pearlescent pigments, such as. B.
  • Monocrystalline pearlescent pigments such as B. Bismuth oxychloride (BiOCI)
  • Layer-substrate pigments e.g. B. mica / metal oxide
  • pearlescent pigments for example, powdered pigments or castor oil dispersions of bismuth oxychloride and / or titanium dioxide and bismuth oxychloride and / or titanium dioxide on mica. Particularly advantageous is e.g. B. the gloss pigment listed under CIN 77163.
  • B the pearlescent pigments available from Merck under the trade names Timiron, Colorona or Dichrona.
  • pearlescent pigments advantageous for the purposes of the present invention are found on numerous known ways available.
  • other substrates besides mica can be coated with other metal oxides, such as. B. silica and the like.
  • metal oxides such as. B. silica and the like.
  • Ronaspheren TiO 2 and Fe O 3 coated SiO 2 particles
  • Iron pearlescent pigments which are produced without the use of mica are particularly preferred.
  • Such pigments are e.g. B. available under the trade name Sicopearl copper 1000 from the company BASF.
  • effect pigments which are available from Flora Tech under the trade name Metasomes Standard / Glitter in various colors (yello, red, green, blue).
  • the glitter particles are present in mixtures with various auxiliaries and dyes (such as, for example, the dyes with the Color Index (Cl) numbers 19140, 77007, 77289, 77491).
  • the dyes and pigments can be present both individually and in a mixture and can be mutually coated, different color effects generally being produced by different coating thicknesses.
  • the total amount of dyes and coloring pigments is advantageously from the range of z. B. 0.1 wt .-% to 30 wt .-%, preferably from 0.5 to 15 wt .-%, in particular from 1, 0 to 10 wt .-%, each based on the total weight of the preparations. It is also advantageous in the sense of the present invention to produce cosmetic and dermatological preparations whose main purpose is not protection against sunlight, but which nevertheless contain other UV protection substances. So z. B. usually incorporated into day creams or makeup products UV-A or UV-B filter substances.
  • UV protection substances like antioxidants and, if desired, preservatives, also provide effective protection of the preparations themselves against spoilage.
  • Cosmetic and dermatological preparations which are in the form of a sunscreen are also favorable.
  • the preparations in the sense of the present invention preferably contain at least one further UV-A, UV-B and / or broadband filter substance.
  • the formulations may, although not necessary, optionally also contain one or more organic and / or inorganic pigments as UV filter substances, which may be present in the water and / or the oil phase.
  • the preparations according to the invention can also advantageously be in the form of so-called oil-free cosmetic or dermatological emulsions which contain a water phase and at least one UV filter substance which is liquid at room temperature as a further phase.
  • Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (TiO 2 ), zinc (ZnO), iron (e.g. Fe 2 O 3 ), zirconium (ZrO 2 ), silicon ( SiO 2 ), manganese (e.g. MnO), aluminum (Al 2 O 3 ), cerium (e.g. Ce 2 O 3 ), mixed oxides of the corresponding metals as well as mixtures of such oxides and the sulfate of barium (BaSO 4 ).
  • the pigments can also advantageously be used in the form of commercially available oily or aqueous predispersions. Dispersing aids and / or solubilizing agents can advantageously be added to these predispersions.
  • the pigments can advantageously be surface-treated (“coated”), for example a hydrophilic, amphiphilic or hydrophobic character. be formed or should be preserved.
  • This surface treatment can consist in that the pigments are provided with a thin hydrophilic and / or hydrophobic inorganic and / or organic layer by methods known per se.
  • the various surface coatings can also contain water in the sense of the present invention.
  • Inorganic surface coatings in the sense of the present invention can consist of aluminum oxide (Al 2 O 3 ), aluminum hydroxide Al (OH) 3 , or aluminum oxide hydrate (also: alumina, CAS no .: 1333-84-2), sodium hexametaphosphate (NaPO 3 ) 6 , sodium metaphosphate (NaPO 3 ) n , silicon dioxide (SiO 2 ) (also: silica, CAS No .: 7631-86-9), or iron oxide (Fe 2 O 3 ).
  • Al 2 O 3 aluminum oxide
  • Al aluminum hydroxide Al
  • Al oxide hydrate also: alumina, CAS no .: 1333-84-2
  • sodium hexametaphosphate (NaPO 3 ) 6 sodium metaphosphate (NaPO 3 ) n
  • silicon dioxide SiO 2
  • silica also: silica, CAS No .: 7631-86-9
  • iron oxide Fe 2 O 3
  • Organic surface coatings in the sense of the present invention can consist of vegetable or animal aluminum stearate, vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methylpolysiloxane (methicone), simethicone (a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane Units and silica gel) or alginic acid.
  • dimethylpolysiloxane also: dimethicone
  • methicone methylpolysiloxane
  • simethicone a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane Units and silica gel
  • alginic acid can consist of vegetable or animal aluminum stearate, vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methylpolysiloxan
  • Zinc oxide particles and predispersions of zinc oxide particles suitable according to the invention are available under the following trade names from the companies listed:
  • Suitable titanium dioxide particles and predispersions of titanium dioxide particles are available under the following trade names from the companies listed:
  • Latex particles which are advantageous according to the invention are those described in the following documents: US Pat. No. 5,663,213 and EP 0 761 201. Particularly advantageous latex particles are those which are formed from water and styrene / acrylate copolymers and, for. B. are available under the trade name "Alliance SunSphere” from Rohm & Haas.
  • UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoyl methane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ® 1789 and is sold by Merck under the trade name Eusolex® 9020.
  • dibenzoyl methane derivatives in particular 4- (tert-butyl) -4'-methoxydibenzoyl methane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ® 1789 and is sold by Merck under the trade name Eusolex® 9020.
  • UV-A filter substances for the purposes of the present invention are hydroxybenzophenones, which are distinguished by the following structural formula:
  • R 1 and R 2 are independently hydrogen, CC 2 o-alkyl, C 3 -C 10 cycloalkyl or C 3 -C 10 cycloalkenyl, the substituents R 1 and R 2 together with the nitrogen atom to which they are attached are bound, can form a 5- or 6-ring and R represents a C 1 -C 20 alkyl radical.
  • a particularly advantageous hydroxybenzophenone in the context of the present invention is 2- (4'-diethylamino-2'-hydoxybenzoyl) benzoic acid hexyl ester (also: aminobenzophenone), which is distinguished by the following structure:
  • Advantageous UV filter substances in the sense of the present invention are also so-called broadband filters, i.e. Filter substances that absorb both UV-A and UV-B radiation.
  • Advantageous broadband filters or UV-B filter substances are, for example, triazine derivatives, such as. B. • 2,4-bis - ⁇ [4- (2-Ethylhexyloxy) -2-hydroxy] phenyl ⁇ -6- (4-methoxyphenyl) -1,3,5-triazine
  • Dioctylbutylamidotriazon (INCI: Diethylhexyl Butamido Triazone), which is available under the trade name UVASORB HEB from Sigma 3V; • 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) tris-benzoic acid tris (2-ethylhexyl ester), also: 2,4,6-tris [anilino - (p-carbo-2 , -ethyl-1'-hexyloxy)] - 1, 3,5-triazine (INCI: Octyl Triazone), which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150.
  • An advantageous broadband filter in the sense of the present invention is also the 2,2'-methylene bis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol ), which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.
  • Another advantageous broadband filter for the purposes of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1, 3,3,3-tetramethyl-1- [(trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.
  • the other UV filter substances can be oil-soluble.
  • Advantageous oil-soluble filter substances are e.g. B .:
  • 3-benzylidene camphor derivatives preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
  • 4-aminobenzoic acid derivatives preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone
  • UV filters are the salts of 2-phenylbenzimidazole-5-sulfonic acid, such as its sodium, potassium or triethanolammonium salt, and the sulfonic acid itself
  • phenylbenzimidazole sulfonic acid (CAS No. 27503-81-7), which is available, for example, under the trade name Eusolex 232 from Merck or under Neo Heliopan Hydro from Haarmann & Reimer.
  • a further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenyl acrylate, sold under the name Uvinul ® N 539 T is available (octocrylene) from BASF.
  • Particularly advantageous preparations within the meaning of the present invention which are distinguished by a high or very high UV-A protection, preferably contain, in addition to the filter substance (s) according to the invention, further UV-A and / or broadband filters, in particular dibenzoylmethane derivatives [ for example the 4- (tert-butyl) -4'-methoxydibenzoylmethane] and / or the 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] - phenyl ⁇ -6- (4-methoxyphenyl) -1, 3,5-triazine, in each case individually or in any combination with one another.
  • dibenzoylmethane derivatives for example the 4- (tert-butyl) -4'-methoxydibenzoylmethane
  • the preparations according to the invention advantageously contain the substances which absorb UV radiation in the UV-A and / or UV-B range in a total amount of, for. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, in particular 1, 0 to 15.0 wt .-%, each based on the total weight of the preparations to cosmetic To provide preparations that protect the hair or skin from the entire range of ultraviolet radiation.
  • film formers may also be advantageous to incorporate film formers into the cosmetic or dermatological preparations according to the invention, for example in order to improve the water resistance of the preparations or to increase the UV protection performance (UV-A and / or UV-B boosting).
  • Both water-soluble or dispersible and fat-soluble film formers are suitable, in each case individually or in combination with one another.
  • B. Polyurethanes e.g. the Avalure® types from Goodrich
  • Dimethicone Copolyol Polyacrylate Silsoft Surface® from the Witco Organo Silicones Group
  • Advantageous fat-soluble film formers are e.g. B., the film formers from the group of polymers based on polyvinylpyrrolidone (PVP)
  • Copolymers of polyvinylpyrrolidone for example the PVP hexadecene copolymer and the PVP eicosene copolymer, which are commercially available, are particularly preferred.
  • Drawings Antaron V216 and Antaron V220 are available from the GAF Chemicals Cooperation, as well as the Tricontayl PVP and the like.
  • Hydrodispersions for use as a lotion, impregnation solution or spray

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques à effet de protection solaire, caractérisées en ce qu'elles contiennent (a) au moins une substance filtrant les U.V., soluble dans l'eau et (b) au moins un dérivé de benzoxazole.
EP02795197A 2001-12-20 2002-12-16 Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole Ceased EP1458345A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10162840A DE10162840A1 (de) 2001-12-20 2001-12-20 Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an wasserlöslichen UV-Filtersubstanzen und Benzoxazol-Derivaten
DE10162840 2001-12-20
PCT/EP2002/014296 WO2003053395A1 (fr) 2001-12-20 2002-12-16 Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole

Publications (1)

Publication Number Publication Date
EP1458345A1 true EP1458345A1 (fr) 2004-09-22

Family

ID=7710102

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02795197A Ceased EP1458345A1 (fr) 2001-12-20 2002-12-16 Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole

Country Status (5)

Country Link
US (1) US7060257B2 (fr)
EP (1) EP1458345A1 (fr)
JP (1) JP2005513094A (fr)
DE (1) DE10162840A1 (fr)
WO (1) WO2003053395A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10238649A1 (de) * 2002-08-23 2004-03-11 Beiersdorf Ag Dünnflüssige kosmetische oder dermatologische Zubereitungen von Typ Öl-in Wasser
DE10245727A1 (de) * 2002-10-01 2004-04-15 Beiersdorf Ag Als Aerosol versprühbare W/O-Emulsionen
US20050008607A1 (en) * 2003-06-05 2005-01-13 L'oreal Composition containing a carbonyl amine
GB0313830D0 (en) * 2003-06-16 2003-07-23 Unichema Chemie Bv Surfactant composition
DE102004002601A1 (de) * 2004-01-15 2005-08-04 Beiersdorf Ag Visualisierung von Sonnenschutzmitteln auf der Haut
DE102004007885A1 (de) * 2004-02-17 2005-09-08 Basf Ag Kosmetische und dermatologische Zubereitungen, enthaltend ein Gemisch aus einem UV-A-Filter, einem UV-B-Filter und einem Metalloxid
DE102004020627A1 (de) 2004-03-23 2005-10-13 Beiersdorf Ag Kosmetische und dermatologische Lichtschutzformulierungen
EP1586306A1 (fr) * 2004-03-23 2005-10-19 Beiersdorf AG Compositions cosmétiques et dermatologiques de protection solaire
FR2879097B1 (fr) * 2004-12-15 2007-04-13 Lcw Les Colorants Wackherr Sa Pigments a base de colorants hydrosolubles lies a une argile
JP2006169194A (ja) * 2004-12-17 2006-06-29 Kao Corp メイクアップ用化粧料
JP2006169195A (ja) * 2004-12-17 2006-06-29 Kao Corp メイクアップ用化粧料
FR2881047A1 (fr) * 2005-01-26 2006-07-28 Oreal Composition photoprotectrice contenant un derive de 1,3,5-triazine, un derive du dibenzoylmethane, et un compose bis-resorcinyl triazine
JP4968706B2 (ja) * 2006-02-20 2012-07-04 株式会社 資生堂 低粘度油中水型乳化化粧料
FR2908306B1 (fr) * 2006-11-09 2010-08-20 Caster Composition cosmetique a base de filtres solaires et d'un polysaccharide particulier
ITMI20070689A1 (it) 2007-04-03 2008-10-04 3V Sigma Spa Metodo per l'ottenimento di emulsioni cosmetiche o/a ad alta resistenza all'acqua
EP1992323B1 (fr) * 2007-05-10 2012-02-08 Neubourg Skin Care GmbH & Co. KG Formulations mousseuses sans tensioactif
US7588702B2 (en) * 2007-08-09 2009-09-15 Hallstar Innovations Corp. Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions
US7597825B2 (en) * 2007-08-09 2009-10-06 Hallstar Innovations Corp. Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions
FR2920978B1 (fr) * 2007-09-14 2012-04-27 Oreal Composition cosmetique comprenant un copolymere cationique et un amidon et procede de traitement cosmetique.
JP4299878B1 (ja) 2008-10-06 2009-07-22 株式会社パラエルモサ 化粧料
DE102009048555B4 (de) 2009-10-07 2011-12-22 Beiersdorf Ag Verwendung von sprühbaren Zubereitungen mit hohem Treibgasanteil
PL2335675T3 (pl) 2009-12-10 2015-08-31 Neubourg Skin Care Gmbh & Co Kg Wolne od emulgatorów, stabilizowane polimerem formulacje pianki
PL2363108T3 (pl) 2010-03-02 2018-04-30 Neubourg Skin Care Gmbh & Co. Kg Formulacje piankowe zawierające co najmniej jeden triterpenoid
CN109223589A (zh) * 2011-11-23 2019-01-18 巴斯夫欧洲公司 油凝胶在uv吸收剂组合物中的用途
JP6255004B2 (ja) * 2013-02-20 2017-12-27 株式会社コーセー エアゾール型日焼け止め化粧料
CN106572953A (zh) * 2014-08-08 2017-04-19 欧莱雅 皂基防晒组合物
US11806412B2 (en) 2014-10-31 2023-11-07 Shiseido Company, Ltd. Oil-in-water emulsion sunscreen cosmetic
JPWO2016068300A1 (ja) * 2014-10-31 2017-08-10 株式会社 資生堂 日焼け止め化粧料
CN109310079A (zh) * 2016-07-15 2019-02-05 狮王株式会社 害虫驱避组合物以及害虫驱避方法
ES2751159B2 (es) * 2018-09-27 2023-02-22 Birding Natura Innovacions S L Cristal laminado trasparente con compuesto reflectante de luz ultravioleta y procedimiento de fabricacion de dicho cristal laminado

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076687A (en) 1976-08-16 1978-02-28 Eastman Kodak Company Bichromophoric benzotriazole-benzoxazole ultraviolet stabilizers and their use in organic compositions
CA1125768A (fr) 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Derives de benzoxazole
LU85304A1 (fr) 1984-04-13 1985-11-27 Oreal Composition solaire filtrante contenant du polyisobutylene et son utilisation pour la protection de l'epiderme humain contre les radiations ultraviolettes
JPH078991B2 (ja) 1989-07-18 1995-02-01 花王株式会社 中性液体洗浄剤組成物
FR2662079B1 (fr) 1990-05-18 1993-11-05 Oreal Emulsion cosmetique filtrante comprenant un filtre uv-a et un filtre uv-b et son utilisation pour la protection de la peau contre les radiations ultraviolettes.
DE4229166A1 (de) * 1992-09-01 1994-03-03 Deutsches Krebsforsch Mittel zur Aufrechterhaltung und/oder Steigerung der Muskelleistung und Körperzellmasse
DE59509233D1 (de) 1994-02-24 2001-06-13 Haarmann & Reimer Gmbh Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren
DE19543730A1 (de) 1995-11-23 1997-05-28 Ciba Geigy Ag Bis-Resorcinyl-Triazine
IT1284525B1 (it) 1996-09-13 1998-05-21 3V Sigma Spa Derivati di benzossazolo loro uso come stabilizzanti contro le radiazioni uv
IT1284526B1 (it) 1996-09-13 1998-05-21 3V Sigma Spa Derivati di benzossazolo loro uso come stabilizzanti contro le radiazioni uv
DE19648010A1 (de) * 1996-11-20 1998-05-28 Haarmann & Reimer Gmbh Verwendung von substituierten Benzazolen als UV-Absorber, neue Benzazole und Verfahren zu ihrer Herstellung
FR2772030B1 (fr) * 1997-12-04 2000-01-28 Oreal Nouveaux derives silicies de benz-x-azoles filtres, compositions cosmetiques photoprotectrices les contenant et utilisations
FR2779957B1 (fr) * 1998-06-18 2000-08-04 Oreal Compositions cosmetiques photoprotectrices contenant un benzazole n-substitue, un derive de 1,3,5-triazine et un filtre organique uv-a
IT1312374B1 (it) 1999-01-11 2002-04-15 3V Sigma Spa Associazioni di filtri solari e composizioni cosmetiche che licontengono
FR2789582B1 (fr) 1999-02-12 2001-05-04 Oreal Compositions photoprotectrices contenant un derive de bis-resorcinyl triazine et un compose a groupements benzoazolyle ou benzodiazolyle
FR2789578A1 (fr) * 1999-02-12 2000-08-18 Oreal Compositions photoprotectrices contenant un derive de benzotriazole et un compose a groupements benzoazolyle ou benzodiazolyle
FR2789581B1 (fr) 1999-02-12 2001-05-04 Oreal Compositions photoprotectrices contenant un derive de benzotriazole, un derive de bis-resorcinyl triazine et un compose a groupements benzoazolyle ou benzodiazolyle
DE19917906A1 (de) 1999-04-20 2000-10-26 Basf Ag Verwendung von aminosubstituierten Hydroxybenzophenonen als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
FR2794645B1 (fr) 1999-06-08 2001-08-10 Oreal Compositions photoprotectrices contenant un compose hydrocarbone bis-hydroxyphenylbenzotriazole et un compose a groupements benzoazolyle ou benzodiazolyle
FR2803194A1 (fr) * 2000-01-03 2001-07-06 Oreal Nouveaux derives de s-triazine, leur procede de preparation, compositions les contenant et leurs utilisations
IT1317825B1 (it) * 2000-02-11 2003-07-15 3V Sigma Spa Derivati del benzossazolo, loro impiego in composizioni cosmetiche enella stabilizzazione di polimeri sintetici.
DE10012408A1 (de) 2000-03-15 2001-09-20 Basf Ag Verwendung von Lichtschutzmittelkombinationen, die als wesentlichen Bestandteil aminosubstituierte Hydroxybenzophenone enthalten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
DE10017214A1 (de) * 2000-04-06 2001-10-11 Beiersdorf Ag Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an unsymmetrisch substituierten Triazinderivaten und Propylenglykoldicaprylatdicaprat
DE10063946A1 (de) 2000-12-20 2002-07-04 Basf Ag Verwendung von Lichtschutzmittelkombinationen, die als wesentlichen Bestandteil 2,2'-p-Phenylen-bis(3,1-benzoxazin-4-on) enthalten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
DE10063867A1 (de) * 2000-12-21 2002-07-11 Haarmann & Reimer Gmbh Kosmetische Lichtschutzzubereitungen
FR2833164B1 (fr) 2001-12-07 2004-07-16 Oreal Compositions cosmetiques antisolaires a base d'un melange synergique de filtres et utilisations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO03053395A1 *

Also Published As

Publication number Publication date
JP2005513094A (ja) 2005-05-12
US7060257B2 (en) 2006-06-13
DE10162840A1 (de) 2003-07-03
US20050048009A1 (en) 2005-03-03
WO2003053395A1 (fr) 2003-07-03

Similar Documents

Publication Publication Date Title
EP1458340A1 (fr) Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des derives de bis-resorcinyltriazine et des derives de benzoxazole
EP1458345A1 (fr) Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole
EP1380288B1 (fr) Compositions cosmétiques et dermatologiques de protection solaire contenant des Polymeres d'acide acrylamidométhylpropane sulfonique (AMPS) hydrophobes
DE10162842A1 (de) Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Benzotriazolen und Benzoxazol-Derivaten
DE10216508A1 (de) Kosmetische und dermatologische Formulierungen mit einem Gehalt an Hydroxybenzophenonen und einem oder mehreren vorgelatinisierten, quervernetzten Stärkederivaten
WO2003053390A1 (fr) Formulations cosmetiques et dermatologiques de protection contre la lumiere contenant des derives benzoxazol
WO2003053393A1 (fr) Formulations de protection solaire cosmetiques et dermatologiques contenant des hydroxylbenzophenones et des derives de benzoxazol
EP1492489B1 (fr) Formulations cosmetiques et dermatologiques de protection solaire resistantes a l'eau contenant des polymeres sequences de polyoxyethylene-polydodecylglycol
DE10214054A1 (de) Wasserfeste kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Alpha Olefin/Maleinsäureanhydrid-Copolymeren
DE10214052A1 (de) Wasserfeste kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an acetylierten Stearinsäureestern
DE10214053A1 (de) Wasserfeste kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Acrylat-Alkylmethacrylat-Copolymeren
DE102004003001B4 (de) Kosmetische und dermatologische Lichtschutzformulierungen
DE10214059A1 (de) Wasserfeste kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Polyoxyethylen-Polyoxypropylen-Blockpolymeren
WO2005067883A1 (fr) Visualisation d'agents de protection solaire sur la peau
EP1555016A1 (fr) Compositions photoprotectrices
DE10249367A1 (de) Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Hydroxybenzophenonen und Benzoxazol-Derivaten
DE102004002602A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut
DE102004002999A1 (de) Kosmetische und dermatologische Lichtschutzformulierungen
DE102004002600A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut
DE102004002601A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut
DE102004002609A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut
WO2005067882A1 (fr) Visualisation d'agents de protection solaire sur la peau
DE102004002607A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut
DE102004002606A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut
DE102004002608A1 (de) Visualisierung von Sonnenschutzmitteln auf der Haut

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040720

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR

17Q First examination report despatched

Effective date: 20070904

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20151113