EP1438323A4 - ADJUVOUS MENINGOCOCCUS COMPOSITIONS - Google Patents

ADJUVOUS MENINGOCOCCUS COMPOSITIONS

Info

Publication number
EP1438323A4
EP1438323A4 EP02800481A EP02800481A EP1438323A4 EP 1438323 A4 EP1438323 A4 EP 1438323A4 EP 02800481 A EP02800481 A EP 02800481A EP 02800481 A EP02800481 A EP 02800481A EP 1438323 A4 EP1438323 A4 EP 1438323A4
Authority
EP
European Patent Office
Prior art keywords
meningococcus
adjuvanted
compositions
meningococcus compositions
adjuvanted meningococcus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02800481A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1438323A2 (en
Inventor
Derek O'hagan
Nicholas Valiante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/010869 external-priority patent/WO2002080648A2/en
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of EP1438323A2 publication Critical patent/EP1438323A2/en
Publication of EP1438323A4 publication Critical patent/EP1438323A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
EP02800481A 2001-10-03 2002-10-03 ADJUVOUS MENINGOCOCCUS COMPOSITIONS Withdrawn EP1438323A4 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US254438 1988-10-06
US32692901P 2001-10-03 2001-10-03
US326929P 2001-10-03
PCT/US2002/010869 WO2002080648A2 (en) 2001-04-05 2002-04-05 Mucosal boosting following parenteral priming
WOPCT/US02/10869 2002-04-05
US37354702P 2002-04-17 2002-04-17
US373547P 2002-04-17
US38067702P 2002-05-13 2002-05-13
US380677P 2002-05-13
US25443802A 2002-09-24 2002-09-24
US0230423 2002-09-24
WOPCT/US02/30423 2002-09-24
PCT/US2002/031726 WO2003028661A2 (en) 2001-10-03 2002-10-03 Adjuvanted meningococcus compositions

Publications (2)

Publication Number Publication Date
EP1438323A2 EP1438323A2 (en) 2004-07-21
EP1438323A4 true EP1438323A4 (en) 2007-08-01

Family

ID=32601151

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02800481A Withdrawn EP1438323A4 (en) 2001-10-03 2002-10-03 ADJUVOUS MENINGOCOCCUS COMPOSITIONS

Country Status (8)

Country Link
EP (1) EP1438323A4 (zh)
JP (1) JP4522699B2 (zh)
CN (1) CN100354297C (zh)
AU (1) AU2002334844B2 (zh)
BR (1) BR0213119A (zh)
CA (1) CA2462646C (zh)
NZ (1) NZ532274A (zh)
WO (1) WO2003028661A2 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
DE60328481D1 (de) * 2002-05-14 2009-09-03 Novartis Vaccines & Diagnostic Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält
GB0302218D0 (en) * 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
WO2004014417A2 (en) * 2002-08-02 2004-02-19 Glaxosmithkline Biologicals Sa Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis
CA2511512C (en) 2002-12-27 2013-10-29 Chiron Corporation Immunogenic compositions containing phospholipid
EP1587537B1 (en) * 2003-01-30 2012-04-11 Novartis AG Injectable vaccines against multiple meningococcal serogroups
ATE426412T1 (de) * 2003-01-30 2009-04-15 Novartis Vaccines & Diagnostic Adjuvante influenza-vakzine
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
PT1631264E (pt) 2003-06-02 2009-11-03 Novartis Vaccines & Diagnostic Composições imunogénicas à base de micropartículas biodegradáveis que compreendem um toxóide de difteria e do tétano
US20050222072A1 (en) * 2004-02-20 2005-10-06 Hybridon, Inc. Potent mucosal immune response induced by modified immunomodulatory oligonucleotides
EP1812056B1 (en) * 2004-11-15 2013-08-07 Novartis Vaccines and Diagnostics, Inc. Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant
AU2006207891C1 (en) 2005-01-28 2011-09-01 Galen Bio, Inc. Immunologically active compositions
ATE438385T1 (de) * 2005-03-02 2009-08-15 Secr Defence Pharmazeutische zusammensetzung
EP2244695A1 (en) 2007-12-07 2010-11-03 Novartis AG Compositions for inducing immune responses
CN101559225B (zh) * 2008-04-18 2012-07-11 北京生物制品研究所 脑膜炎球菌疫苗
BR112014032207B1 (pt) * 2012-06-21 2021-07-27 Northwestern University Composição compreendendo um antígeno acoplado a uma partícula transportadora e uso de um antígeno acoplado a uma partícula transportadora

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
DE69841807D1 (de) * 1997-11-06 2010-09-16 Novartis Vaccines & Diagnostic Neisseriale antigene
SG123535A1 (en) * 1998-01-14 2006-07-26 Chiron Srl Neisseria meningitidis antigens
NZ508366A (en) * 1998-05-01 2004-03-26 Chiron Corp Neisseria meningitidis antigens and compositions
ES2260923T3 (es) * 1998-07-29 2006-11-01 Chiron Corporation Micorparticulas con superficies adsorbentes, procedimientos de fabricacion y uso de las mismas.
NZ511540A (en) * 1998-10-09 2004-05-28 Chiron Corp Neisseria genomic sequences and methods of their use
JP2002537102A (ja) * 1999-02-26 2002-11-05 カイロン コーポレイション 吸着された高分子および微粒子を有するミクロエマルジョン
EP1154790B1 (en) * 1999-02-26 2004-10-20 Chiron S.r.l. Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs
JP2003518363A (ja) * 1999-04-30 2003-06-10 カイロン エセ．ピー．アー． 保存されたナイセリア抗原
CN1800385B (zh) * 2000-02-28 2010-06-02 启龙有限公司 奈瑟球菌蛋白质的异源表达

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
O'HAGAN D T ET AL: "POLY(LACTIDE-CO-GLYCOLIDE) MICROPARTICLES FOR THE DEVELOPMENT OF SINGLE-DOSE CONTROLLED-RELEASE VACCINES", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 32, 1998, pages 225 - 246, XP000944990, ISSN: 0169-409X *
SINGH M ET AL: "ADVANCES IN VACCINE ADJUVANTS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 17, no. 11, November 1999 (1999-11-01), pages 1075 - 1081, XP000941305, ISSN: 1087-0156 *
SINGH M ET AL: "Cationic microparticles are an effective delivery system for immunie stimulatory CpG DNA", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 18, no. 10, October 2001 (2001-10-01), pages 1476 - 1479, XP002976979, ISSN: 0724-8741 *

Also Published As

Publication number Publication date
BR0213119A (pt) 2004-12-28
NZ532274A (en) 2006-02-24
CN1599746A (zh) 2005-03-23
AU2002334844B2 (en) 2007-08-02
WO2003028661A3 (en) 2003-10-09
WO2003028661A2 (en) 2003-04-10
EP1438323A2 (en) 2004-07-21
JP4522699B2 (ja) 2010-08-11
CN100354297C (zh) 2007-12-12
JP2005526697A (ja) 2005-09-08
AU2002334844B8 (en) 2003-04-14
CA2462646C (en) 2013-02-12
CA2462646A1 (en) 2003-04-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20040420

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20070704

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 39/385 20060101ALI20070628BHEP

Ipc: A61K 39/095 20060101ALI20070628BHEP

Ipc: A61K 39/02 20060101AFI20070628BHEP

17Q First examination report despatched

Effective date: 20101020

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140501