EP1358938A1 - Dispositif collecteur - Google Patents

Dispositif collecteur Download PDF

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Publication number
EP1358938A1
EP1358938A1 EP02023734A EP02023734A EP1358938A1 EP 1358938 A1 EP1358938 A1 EP 1358938A1 EP 02023734 A EP02023734 A EP 02023734A EP 02023734 A EP02023734 A EP 02023734A EP 1358938 A1 EP1358938 A1 EP 1358938A1
Authority
EP
European Patent Office
Prior art keywords
container
liquid
film
tube
moisture barrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02023734A
Other languages
German (de)
English (en)
Inventor
Yong Jae Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of EP1358938A1 publication Critical patent/EP1358938A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/003—Articles enclosed in rigid or semi-rigid containers, the whole being wrapped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation

Definitions

  • the subject invention relates to plastic tubes that have been prefilled with controlled volumes and concentrations of liquid, and that are packaged to retain the liquid volume and concentration during storage.
  • Drugs that are administered intravenously must be in a liquid form.
  • the liquid must be of known volume and concentration to ensure proper dosage.
  • Some drugs can be stored for considerable periods of time in a liquid form. Other drugs, however, must be stored in a powdered form, and then must be mixed with a specified volume of a liquid additive shortly prior to administration to the patient. Efficiencies can be achieved if the specified volume of the liquid drug and/or the specified volume of the liquid additive is available in a prefilled tube or other such container. Prefilled containers avoid the need for careful volummetric measuring immediately prior to administering the drug, and hence minimize the chance for error.
  • Plastic tubes and other plastic containers are lightweight, relatively inexpensive and relatively unbreakable. As a result, plastic tubes are used for medical applications whenever possible. However, plastic tubes have an inherent permeability to water and other liquids. This high liquid permeability of plastics can significantly affect the volume, concentration and solubility of liquids that are stored for a long period of time in a plastic container. Containers filled with a liquid drug or with a liquid additive for a powdered drug desirably should have a relatively long shelf life. As a result, plastic containers are considered unacceptable for long term storage of liquid drugs or liquid additives for drugs.
  • Glass is substantially impermeable to water and other liquids.
  • liquid drugs or liquid additives for drugs typically are stored in glass tubes or other glass containers.
  • glass is much more breakable than plastic.
  • a glass tube can be broken easily while the tube is being manipulated to access the liquid stored therein.
  • a small round glass tube can be dropped inadvertently and shattered inadvertently. Sharp edges of a broken glass tube can cut a patient or health care worker, and may create an open wound that can lead to disease transmission.
  • Fragile glass containers also require protective packaging that typically increases storage space requirements and that may add to costs.
  • the prior art has included attempts to minimize or offset the loss of liquid from plastic tubes. For example, one prior art attempt has bulk packaged a plurality of plastic tubes in a plastic tub. A moisture source also has been placed in the tub to provide a higher vapor content surrounding the bulk packaged tubes, and thereby to impede the outflow of liquid from the tubes. This prior art bulk packaging complicates the packaging process and adds to cost and storage space requirements. Furthermore, vapor from the moisture source is transported through the permeable walls of the plastic tub.
  • the prior art also includes tubes that are laminated with foil to prevent liquid loss. Foil lamination of tubes adds significantly to the tube manufacturing complexity and adds to tube manufacturing cost.
  • the subject invention is directed to a plastic container in which a liquid drug or a liquid additive solution for a drug has been placed.
  • the plastic container may be formed from a known plastic material, such as polyethylene terephthalate (PET), polypropylene or other plastic material that exhibits liquid permeability.
  • PET polyethylene terephthalate
  • the container may be a tube of prior art construction, and may include a closed bottom, an open top and a continuous side wall extending therebetween.
  • a closure may be securely mounted to the container for closing the open top, and thereby preventing spillage of the liquid drug or the liquid additive stored in the container.
  • the subject invention further includes packaging formed from a high moisture barrier material that completely surrounds the container or that completely surrounds a plurality of such containers.
  • the high moisture barrier material may be a film formed from a foil lamination, a metalized polyester, SiOx coated polyesters, polyester-polyoefilins, PVDC or the like.
  • This high moisture barrier material may be a sheet folded around one or more plastic containers of a liquid drug or liquid additive. Edge regions of the sheet then may be sealed in face-to-face engagement with other areas on the sheet. Alternatively a container may be placed between two sheets of high moisture barrier material, and edge regions of the sheets may be sealed.
  • the high moisture barrier packaging material can impede the rate of water vapor transport across the plastic material from which the container is formed by providing and maintaining a high relative humidity environment around the container and inside the package. This enables the volume, concentration and solubility of the liquid in the container to be controlled, and enables a longer shelf life for the liquid therein.
  • FIG. 1 is a top plan view of a liquid-containing plastic tube packaged in accordance with the subject invention.
  • FIG. 2 is a cross-sectional view taken along line 2-2 in FIG. 1.
  • FIG.. 3 is a cross-sectional view similar to FIG. 2, but showing an alternate package.
  • a package in accordance with the subject invention is identified generally by the numeral 10 in FIGS. 1 and 2.
  • Package 10 contains a tube 12 formed from a plastic material, such as polyethylene terephthalate (PET) or polypropylene.
  • Tube 12 includes a closed bottom 14 , an open top 16 , and a cylindrical side wall 18 extending therebetween.
  • a liquid 20 is disposed in tube 12 as shown in FIG. 2.
  • Liquid 20 may be a liquid additive of a specified volume, concentration and solubility that is intended for mixing with a non-liquid drug and for subsequent administration to a patient.
  • liquid 20 may be a liquid drug.
  • Closure 22 comprises a thermoplastic elastomer or a thermoset resin material that is sufficiently deformable and resilient for secure sealing engagement with side wall 18 of tube 12 .
  • Closure 22 may further include a more rigid plastic structure to which the thermoplastic elastomer or thermoset resin is secured to enable closure 22 to be placed in and removed from tube 12 with ease.
  • package 10 comprises a high moisture barrier film 26 that completely and relatively closely surrounds tube 12 .
  • Film 26 may be a foil lamination comprising a substrate formed from a metallic foil, such as aluminum, and at least one layer formed from a plastic material that is readily sealable.
  • the foil lamination may include an outer layer that is well suited to printing indicia to identify the specific liquid additive in tube 12 .
  • Film 26 alternatively may be a metalized polyester, a SiOx coated polyester, a polyester-polyoefilin or PVDC, all of which are substantially impermeable to water, particularly in comparison to the PET or polypropylene from which tube 12 is formed.
  • Film 26 of package 10 may define an envelope formed from a single sheet that is folded at fold region 28 to closely surround tube 12 . Adjacent registered edges 30 may be bonded in face-to-face relationship as shown in FIG. 2.
  • package 10 may be formed from two separate sheets of film 26a and 26b as shown in FIG. 3. Sheets 26a and 26b may originally be in strip form. Tube 12 with liquid 20 therein may be placed on a lower sheet of film 26a , which may be part of a strip moving longitudinally along a conveying apparatus. Upper sheet of film 26b may be part of a second strip that is fed into juxtaposed relationship to the strip defining lower sheet of film 26a .
  • the lower and upper sheets 26a and 26b may be sealed along opposed side edges 30a , and may subsequently be sealed and cut between adjacent tubes to form seals 32 .
  • the lower and upper sheets of film 26a and 26b may be formed from different materials.
  • a lower sheet of film 26a may be a foil lamination having an only upper layer of a plastic material that will bond well with a lower plastic layer on upper sheet 26b .
  • Upper sheet 26b may also include an upper laminated layer that is well suited to receiving printed indicia.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP02023734A 2002-04-26 2002-10-23 Dispositif collecteur Withdrawn EP1358938A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37614902P 2002-04-26 2002-04-26
US376149P 2002-04-26

Publications (1)

Publication Number Publication Date
EP1358938A1 true EP1358938A1 (fr) 2003-11-05

Family

ID=29215903

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02023734A Withdrawn EP1358938A1 (fr) 2002-04-26 2002-10-23 Dispositif collecteur

Country Status (2)

Country Link
US (1) US20030200727A1 (fr)
EP (1) EP1358938A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3738638A1 (fr) 2012-03-15 2020-11-18 Fisher & Paykel Healthcare Limited Système d'humidification de gaz respiratoire
GB2572693B (en) 2012-04-27 2020-01-01 Fisher & Paykel Healthcare Ltd Humidification apparatus with a sensor cartridge coupled to a heater base via a spine
GB2584026B (en) 2013-09-13 2021-03-17 Fisher & Paykel Healthcare Ltd A heater base for supplying humidified gases to a patient
EP3043855B1 (fr) 2013-09-13 2020-02-26 Fisher & Paykel Healthcare Limited Raccords pour système d'humidification
GB2558102B (en) 2013-12-20 2018-11-28 Fisher & Paykel Healthcare Ltd Humidification system connections
US10449319B2 (en) 2014-02-07 2019-10-22 Fisher & Paykel Healthcare Limited Respiratory humidification system
WO2015167347A1 (fr) 2014-05-02 2015-11-05 Fisher & Paykel Healthcare Limited Dispositif d'humidification de gaz
CN106535976B (zh) 2014-05-13 2019-04-05 费雪派克医疗保健有限公司 用于呼吸增湿系统的可用性特征
US11324911B2 (en) 2014-06-03 2022-05-10 Fisher & Paykel Healthcare Limited Flow mixers for respiratory therapy systems
US11278689B2 (en) 2014-11-17 2022-03-22 Fisher & Paykel Healthcare Limited Humidification of respiratory gases
SG10202106016TA (en) 2016-12-07 2021-07-29 Fisher and paykel healthcare ltd Sensing arrangements for medical devices

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038148A (en) * 1975-12-22 1977-07-26 Marion Laboratories, Inc. Anaerobic environmental system for bacteria culture testing
EP0520443A2 (fr) * 1991-06-26 1992-12-30 Ppg Industries, Inc. Construction d'un capteur électrochimique
EP0787823A2 (fr) * 1996-01-30 1997-08-06 Becton, Dickinson and Company Tube de prélèvement du sang
WO1999022691A1 (fr) * 1997-10-31 1999-05-14 Abbott Laboratories Systeme de stockage de compositions sensibles a l'oxygene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2283867A (en) * 1939-12-19 1942-05-19 Stokes Machine Co Packaging and preserving dried biologicals, pharmaceuticals, and the like
US4108309A (en) * 1976-10-15 1978-08-22 All One God Faith, Inc. Contraceptive containing device
US4927010A (en) * 1988-12-27 1990-05-22 Sealed Air Corporation Shipping bag for containers of potentially biohazardous liquids
US4942966A (en) * 1989-06-05 1990-07-24 Kemp David R Containment device for a test tube
GB9411626D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Package
US5647480A (en) * 1995-01-27 1997-07-15 Minnesota Mining And Manufacturing Company Flexible pressure vessels for and method of transporting hazardous materials
CA2286002C (fr) * 1997-04-10 2008-01-29 Andrew N. Lamborne Seringue a gaz et son emballage
US6119853A (en) * 1998-12-18 2000-09-19 Glaxo Wellcome Inc. Method and package for storing a pressurized container containing a drug
US6308827B1 (en) * 1999-02-10 2001-10-30 Technicor Inc. Labeling system for vial container
US6161687A (en) * 1999-02-10 2000-12-19 Technicor, Inc. Vial container

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038148A (en) * 1975-12-22 1977-07-26 Marion Laboratories, Inc. Anaerobic environmental system for bacteria culture testing
EP0520443A2 (fr) * 1991-06-26 1992-12-30 Ppg Industries, Inc. Construction d'un capteur électrochimique
EP0787823A2 (fr) * 1996-01-30 1997-08-06 Becton, Dickinson and Company Tube de prélèvement du sang
WO1999022691A1 (fr) * 1997-10-31 1999-05-14 Abbott Laboratories Systeme de stockage de compositions sensibles a l'oxygene

Also Published As

Publication number Publication date
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