EP1306367A4 - Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten - Google Patents

Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten

Info

Publication number
EP1306367A4
EP1306367A4 EP01951935A EP01951935A EP1306367A4 EP 1306367 A4 EP1306367 A4 EP 1306367A4 EP 01951935 A EP01951935 A EP 01951935A EP 01951935 A EP01951935 A EP 01951935A EP 1306367 A4 EP1306367 A4 EP 1306367A4
Authority
EP
European Patent Office
Prior art keywords
sulfonic acid
acid derivatives
medicinal products
hydroxamic acids
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01951935A
Other languages
English (en)
French (fr)
Other versions
EP1306367A1 (de
EP1306367B1 (de
Inventor
Kazuhiro Maeda
Shuji Sonda
Tadahiro Takemoto
Tomokazu Goto
Fujio Kobayashi
Masahiko Kajii
Naruyasu Komorita
Fumihiro Hirayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of EP1306367A1 publication Critical patent/EP1306367A1/de
Publication of EP1306367A4 publication Critical patent/EP1306367A4/de
Application granted granted Critical
Publication of EP1306367B1 publication Critical patent/EP1306367B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/11—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP01951935A 2000-07-19 2001-07-19 Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten Expired - Lifetime EP1306367B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000219245 2000-07-19
JP2000219245 2000-07-19
JP2000219034 2000-07-19
JP2000219034 2000-07-19
PCT/JP2001/006275 WO2002006214A1 (fr) 2000-07-19 2001-07-19 Derives a l'acide sulfonique d'acides hydroxamiques et leur utilisation comme produits medicaux

Publications (3)

Publication Number Publication Date
EP1306367A1 EP1306367A1 (de) 2003-05-02
EP1306367A4 true EP1306367A4 (de) 2004-06-09
EP1306367B1 EP1306367B1 (de) 2007-07-18

Family

ID=26596313

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01951935A Expired - Lifetime EP1306367B1 (de) 2000-07-19 2001-07-19 Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten

Country Status (9)

Country Link
US (1) US6989401B2 (de)
EP (1) EP1306367B1 (de)
KR (1) KR100799192B1 (de)
CN (1) CN1215052C (de)
AT (1) ATE367374T1 (de)
AU (1) AU2001272761A1 (de)
CA (1) CA2415954A1 (de)
DE (1) DE60129442T2 (de)
WO (1) WO2002006214A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829085B2 (en) 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
JPWO2004085396A1 (ja) * 2003-03-26 2006-06-29 三菱ウェルファーマ株式会社 虚血再灌流障害の予防または治療剤、臓器保存剤およびスクリーニング方法
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
EP1706079B1 (de) 2003-08-14 2013-02-20 ThromboGenics N.V. Antikörper gegen faktor viii mit modifizierter glykosilierung in der variablen region
WO2005037265A1 (ja) * 2003-10-17 2005-04-28 Mitsubishi Pharma Corporation 併用薬剤
TW200526577A (en) * 2003-11-17 2005-08-16 Wyeth Corp Processes for the preparation of N-substituted phthalimides
AU2005210581B2 (en) 2004-02-04 2010-06-24 Am-Pharma B.V. Use of alkaline phosphatase for the detoxification of LPS present at mucosal barriers
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
CA2666246C (en) * 2006-10-12 2013-12-31 Bellus Health (International) Limited Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
CN104854082A (zh) * 2012-07-20 2015-08-19 中央研究院 3,5,n-三羟基烷酰胺及其衍生物、及其制造方法与用途
KR102166110B1 (ko) 2014-01-24 2020-10-16 에이엠-파마 비.브이. 키메라 알칼리성 포스파타제-유사 단백질
JP6713147B2 (ja) 2014-01-24 2020-06-24 アーエム−ファルマ ベー．フェー．ＡＭ−Ｐｈａｒｍａ Ｂ．Ｖ． アルカリホスファターゼの下流プロセシング
RU2765098C2 (ru) * 2017-02-28 2022-01-25 Иммуноджен, Инк. Производные майтанзиноида с саморасщепляющимися пептидными линкерами и их конъюгаты

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061642A1 (en) * 1998-05-27 1999-12-02 Cell Genesys, Inc. Recombinant aav vectors for gene therapy of hemophilia a

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
US5318964A (en) 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
EP0689538B1 (de) 1993-03-16 1998-08-12 British Biotech Pharmaceuticals Limited Hydroxamsaeurederivate als metalloproteinase inhibitoren
JPH07157470A (ja) 1993-03-18 1995-06-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
DE69632821T2 (de) * 1995-04-25 2005-08-25 Daiichi Fine Chemical Co., Ltd., Takaoka In wasser hochlöslicher metalloproteinase-inhibitor
CA2332946A1 (en) * 1998-05-22 1999-12-02 Welfide Corporation Hydroxamic acid derivative and pharmaceutical use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061642A1 (en) * 1998-05-27 1999-12-02 Cell Genesys, Inc. Recombinant aav vectors for gene therapy of hemophilia a

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LÄHDESMÄKI ET AL.: "Non-coded biosynthesis of N-acetylaspartyl peptides in mouse brain homogenates", JOURNAL OF LIQUID CHROMATOGRAPHY, vol. 5, no. 5, 1982, pages 989 - 1002, XP009029260 *

Also Published As

Publication number Publication date
DE60129442D1 (de) 2007-08-30
KR100799192B1 (ko) 2008-01-31
CN1443158A (zh) 2003-09-17
EP1306367A1 (de) 2003-05-02
KR20030029628A (ko) 2003-04-14
EP1306367B1 (de) 2007-07-18
US6989401B2 (en) 2006-01-24
WO2002006214A1 (fr) 2002-01-24
ATE367374T1 (de) 2007-08-15
US20030176486A1 (en) 2003-09-18
CN1215052C (zh) 2005-08-17
AU2001272761A1 (en) 2002-01-30
CA2415954A1 (en) 2003-01-17
DE60129442T2 (de) 2008-04-17

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