AU2001272761A1 - Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products - Google Patents

Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products

Info

Publication number
AU2001272761A1
AU2001272761A1 AU2001272761A AU7276101A AU2001272761A1 AU 2001272761 A1 AU2001272761 A1 AU 2001272761A1 AU 2001272761 A AU2001272761 A AU 2001272761A AU 7276101 A AU7276101 A AU 7276101A AU 2001272761 A1 AU2001272761 A1 AU 2001272761A1
Authority
AU
Australia
Prior art keywords
sulfonic acid
acid derivatives
medicinal products
hydroxamic acids
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001272761A
Inventor
Tomokazu Goto
Fumihiro Hirayama
Masahiko Kajii
Fujio Kobayashi
Naruyasu Komorita
Kazuhiro Maeda
Shuji Sonda
Tadahiro Takemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of AU2001272761A1 publication Critical patent/AU2001272761A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/11—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom

Abstract

The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.
AU2001272761A 2000-07-19 2001-07-19 Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products Abandoned AU2001272761A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000-219245 2000-07-19
JP2000219034 2000-07-19
JP2000-219034 2000-07-19
JP2000219245 2000-07-19
PCT/JP2001/006275 WO2002006214A1 (en) 2000-07-19 2001-07-19 Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products

Publications (1)

Publication Number Publication Date
AU2001272761A1 true AU2001272761A1 (en) 2002-01-30

Family

ID=26596313

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001272761A Abandoned AU2001272761A1 (en) 2000-07-19 2001-07-19 Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products

Country Status (9)

Country Link
US (1) US6989401B2 (en)
EP (1) EP1306367B1 (en)
KR (1) KR100799192B1 (en)
CN (1) CN1215052C (en)
AT (1) ATE367374T1 (en)
AU (1) AU2001272761A1 (en)
CA (1) CA2415954A1 (en)
DE (1) DE60129442T2 (en)
WO (1) WO2002006214A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016455A2 (en) 2003-08-14 2005-02-24 D. Collen Research Foundation Vzw Antibodies against factor viii with modified glycosylation in the variable region
US7829085B2 (en) 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
WO2004085396A1 (en) * 2003-03-26 2004-10-07 Mitsubishi Pharma Corporation Preventive or therapeutic agent for ischemia/reperfusion injury, organ preservative, and screening method
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
JPWO2005037265A1 (en) * 2003-10-17 2006-12-28 三菱ウェルファーマ株式会社 Concomitant drugs
JP2007515403A (en) * 2003-11-17 2007-06-14 ワイス Method for preparing N-substituted phthalimide
US8574863B2 (en) 2004-02-04 2013-11-05 Pharmaaware Sepsis B.V. Alkaline phosphatase for treating an inflammatory disease of the gastro-intestinal tract
AU2005326962A1 (en) 2004-12-22 2006-08-17 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
EA016568B1 (en) 2006-10-12 2012-05-30 Беллус Хелс (Интернэшнл) Лимитед Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
US9353061B2 (en) 2012-07-20 2016-05-31 Academia Sinica 3,5,N-trihydroxy-alkanamide and derivatives: method for making same and use thereof
KR102166110B1 (en) 2014-01-24 2020-10-16 에이엠-파마 비.브이. Chimeric alkaline phosphatase-like proteins
ES2688066T3 (en) 2014-01-24 2018-10-30 Am-Pharma B.V. Processing for recovery and purification of an alkaline phosphatase
TW202320794A (en) * 2017-02-28 2023-06-01 美商伊繆諾金公司 Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
US5318964A (en) 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
GB9223904D0 (en) 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
CA2158352A1 (en) 1993-03-16 1994-09-29 Michael John Crimmin Hydroxamic acid derivatives as metalloproteinase inhibitors
JPH07157470A (en) 1993-03-18 1995-06-20 Otsuka Pharmaceut Co Ltd Carbostyril derivative
DE69632821T2 (en) * 1995-04-25 2005-08-25 Daiichi Fine Chemical Co., Ltd., Takaoka HIGHLY METALOPROTEINASE INHIBITOR IN WATER
US6610729B1 (en) * 1998-05-22 2003-08-26 Mitsubishi Pharma Corporation Hydroxamic acid derivatives and medicinal utilization thereof
US6797505B2 (en) * 1998-05-27 2004-09-28 Cell Genesys, Inc. Recombinant AAV vectors for gene therapy of hemophilia A

Also Published As

Publication number Publication date
CN1215052C (en) 2005-08-17
US20030176486A1 (en) 2003-09-18
KR100799192B1 (en) 2008-01-31
EP1306367A4 (en) 2004-06-09
CN1443158A (en) 2003-09-17
CA2415954A1 (en) 2003-01-17
KR20030029628A (en) 2003-04-14
EP1306367A1 (en) 2003-05-02
DE60129442T2 (en) 2008-04-17
US6989401B2 (en) 2006-01-24
WO2002006214A1 (en) 2002-01-24
DE60129442D1 (en) 2007-08-30
ATE367374T1 (en) 2007-08-15
EP1306367B1 (en) 2007-07-18

Similar Documents

Publication Publication Date Title
DE69830504D1 (en) ANTITROMOMBOTIC MEANS
ES2182852T3 (en) PROLINAMIDE DERIVATIVES
AU2002211216A1 (en) Substituted aminopropoxyaryl derivatives useful as agonists for lxr
WO2001019776A3 (en) Novel derivatives of dicarboxylic acid having pharmaceutical properties
BR9905981A (en) Isochromanic compounds and processes for their production.
ATE306261T1 (en) ANTITHROMBOTIC AGENTS
EA200300065A1 (en) OXIDIZED COMPLEX ETHERS OF 4-IODPHENYLAMINOBENE HYDROXAMIC ACIDS
AU2001272761A1 (en) Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
NO20024772D0 (en) Percyquinnin, process for its preparation and its use as a drug
AU2055500A (en) Aromatic amides
WO2002010154A3 (en) Substituted heterocyclic amides
DK1004578T3 (en) 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
MY123908A (en) Meta-azacyclic amino benzoic acid compounds and derivatives thereof
CA2412047A1 (en) Shortened synthesis of 3,3-diarylpropylamine derivatives
IL136100A (en) Biphenylamidine derivatives and pharmaceutical compositions containing the same
DE60114640D1 (en) Antithrombosemittel
PL377478A1 (en) Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
DK1180094T3 (en) Condensed polycyclic amino acids as pharmaceuticals
WO2004048381A3 (en) Pyrazoloazepine compounds as pharmaceutical agents
WO2001083423A3 (en) 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof
HUP0401895A2 (en) N-formyl derivatives of paroxetine, process for their preparation and pharmaceutical compositions containing them
EP1306368A3 (en) 3,4-dihydro-1H-naphtalene derivatives as a highly selective cyclooxygenase-2 inhibitor
WO2003104189A3 (en) 4-pyrazol-phenylalanine derivatives as ace-nep inhibitors
AU2002359044A1 (en) Bipyridinyl derivatives as a highly selective cyclooxygenase-2 inhibitor
BG103923A (en) Sulphate salt of hiv protease inhibitor with improved peroral absorption and biopresence