EP1298144A3 - Monoklonaler anti-idiotypischer Antikörper aus der Maus 3H1 - Google Patents
Monoklonaler anti-idiotypischer Antikörper aus der Maus 3H1 Download PDFInfo
- Publication number
- EP1298144A3 EP1298144A3 EP02014310A EP02014310A EP1298144A3 EP 1298144 A3 EP1298144 A3 EP 1298144A3 EP 02014310 A EP02014310 A EP 02014310A EP 02014310 A EP02014310 A EP 02014310A EP 1298144 A3 EP1298144 A3 EP 1298144A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- monoclonal anti
- idiotype antibody
- cea
- murine monoclonal
- provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36548494A | 1994-12-28 | 1994-12-28 | |
| US365484 | 1994-12-28 | ||
| EP95944582A EP0796280B1 (de) | 1994-12-28 | 1995-12-28 | Monoklonaler anti-idiotypischer antikörper 3h1 aus maus |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP95944582A Division EP0796280B1 (de) | 1994-12-28 | 1995-12-28 | Monoklonaler anti-idiotypischer antikörper 3h1 aus maus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1298144A2 EP1298144A2 (de) | 2003-04-02 |
| EP1298144A3 true EP1298144A3 (de) | 2006-05-31 |
Family
ID=23439088
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02014310A Withdrawn EP1298144A3 (de) | 1994-12-28 | 1995-12-28 | Monoklonaler anti-idiotypischer Antikörper aus der Maus 3H1 |
| EP95944450A Expired - Lifetime EP0800578B1 (de) | 1994-12-28 | 1995-12-28 | Rekombinierte sequenzen des monoklonalen anti-idiotypischen antikörpers 3h1, diean dem menschlichen karzioembyonischen antigen liiert sind |
| EP95944582A Expired - Lifetime EP0796280B1 (de) | 1994-12-28 | 1995-12-28 | Monoklonaler anti-idiotypischer antikörper 3h1 aus maus |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP95944450A Expired - Lifetime EP0800578B1 (de) | 1994-12-28 | 1995-12-28 | Rekombinierte sequenzen des monoklonalen anti-idiotypischen antikörpers 3h1, diean dem menschlichen karzioembyonischen antigen liiert sind |
| EP95944582A Expired - Lifetime EP0796280B1 (de) | 1994-12-28 | 1995-12-28 | Monoklonaler anti-idiotypischer antikörper 3h1 aus maus |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5977315A (de) |
| EP (3) | EP1298144A3 (de) |
| JP (2) | JPH10511846A (de) |
| AT (2) | ATE235514T1 (de) |
| AU (2) | AU704829B2 (de) |
| CA (2) | CA2209360C (de) |
| DE (2) | DE69530107T2 (de) |
| DK (2) | DK0796280T3 (de) |
| ES (2) | ES2197217T3 (de) |
| MX (2) | MX9704897A (de) |
| PT (2) | PT796280E (de) |
| WO (2) | WO1996020219A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2197217T3 (es) * | 1994-12-28 | 2004-01-01 | University Of Kentucky Research Foundation | Anticuerpo 3h1 monoclonal anti-id-murino. |
| US6235280B1 (en) * | 1996-04-12 | 2001-05-22 | Malaya Chatterjee | Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1 |
| US20020041872A1 (en) | 1996-04-12 | 2002-04-11 | Malaya Chatterjee | Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1 |
| US7318921B2 (en) * | 1996-05-15 | 2008-01-15 | Altarex Medical Corp. | Therapeutic compositions that alter the immune response |
| US20080220012A1 (en) * | 1996-05-15 | 2008-09-11 | Ragupathy Madiyalakan | Therapeutic Compositions that alter the immune response |
| WO1997042973A1 (en) * | 1996-05-15 | 1997-11-20 | Altarex, Corp. | Method and composition for reconforming multi-epitopic antigens to initiate an immune response |
| US20020098190A1 (en) * | 1997-06-13 | 2002-07-25 | Malaya Chatterjee | Compositions and methods for treating tumors bearing HMFG and CEA antigens |
| NZ501990A (en) * | 1997-07-08 | 2002-09-27 | Viventia Biotech Inc | Compositions containing antigen-binding fragments that recognise the antigen recognised by a recombinant 4B5 antibody |
| US7569674B2 (en) | 1998-05-04 | 2009-08-04 | Innexus Biotechnology International Limited | Autophilic antibodies |
| US6355244B1 (en) | 1997-11-17 | 2002-03-12 | University Of Kentucky Research Foundation | Methods and compositions for the treatment of psoriasis |
| AT409086B (de) * | 1999-11-16 | 2002-05-27 | Igeneon Krebs Immuntherapie | Neue verwendung von antikörpern als impfstoffe |
| US6774209B1 (en) * | 2000-04-03 | 2004-08-10 | Dyax Corp. | Binding peptides for carcinoembryonic antigen (CEA) |
| US8101200B2 (en) | 2000-04-13 | 2012-01-24 | Angiotech Biocoatings, Inc. | Targeted therapeutic agent release devices and methods of making and using the same |
| US20020139628A1 (en) * | 2001-03-30 | 2002-10-03 | Wen-Chen Chang | Retractable handle assembly |
| US8025873B2 (en) | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| AT500650B1 (de) * | 2003-04-17 | 2009-11-15 | Altropus Gmbh | Immunogener rekombinanter antikörper |
| US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
| KR20070051848A (ko) * | 2004-08-05 | 2007-05-18 | 알 앤 디 그린 머티리얼, 엘엘씨 | 고체 생분해성 제품 제조를 위한 저온 몰딩 방법 |
| CA2589009A1 (en) * | 2004-11-24 | 2006-06-01 | Health Research Inc. | Method for identifying and designing immunogenic peptides |
| TW200732346A (en) * | 2005-10-13 | 2007-09-01 | Virexx Medical Corp | Chimeric hepatitis C virus antigens for eliciting an immune response |
| EP1999153B1 (de) * | 2006-03-29 | 2014-04-23 | King's College London | Agonistische antikörper gegen tshr |
| TWI434855B (zh) * | 2006-11-21 | 2014-04-21 | Hoffmann La Roche | 結合物及其在免疫分析中作為參考標準之用途 |
| CN101854946B (zh) | 2007-11-08 | 2013-07-03 | 尼尔詹尼克斯肿瘤研究公司 | 结肠癌和胰腺癌的重组单克隆抗体和相应抗原 |
| US8093018B2 (en) * | 2008-05-20 | 2012-01-10 | Otsuka Pharmaceutical Co., Ltd. | Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same |
| MX2012004877A (es) | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
| SG189391A1 (en) | 2010-10-18 | 2013-05-31 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| AU2012278802B2 (en) | 2011-07-06 | 2015-11-26 | Société des Produits Nestlé S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with TNF alpha |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| JP2018500553A (ja) | 2014-12-05 | 2018-01-11 | ネステク ソシエテ アノニム | 患者試料における生物製剤の検出のための間接的均一移動度シフトアッセイ |
| BR112020018709A2 (pt) | 2018-03-28 | 2021-01-05 | Bristol-Myers Squibb Company | Proteínas de fusão do receptor alfa de interleucina-2/interleucina-2 e métodos de uso |
| CN119708155B (zh) * | 2024-12-30 | 2025-12-09 | 中国药科大学 | 地龙抗血小板寡肽及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| JPS54140710A (en) * | 1978-03-10 | 1979-11-01 | Mitsui Toatsu Chem Inc | Anti-tumor substance and its preparation |
| JPS56145222A (en) * | 1980-04-28 | 1981-11-11 | Toshiyuki Hamaoka | Improved antibody and its preparation |
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4436728A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US5053224A (en) | 1983-11-07 | 1991-10-01 | Hilary Koprowski | Induction of antibody response to solid tumors with anti-idiotype antibodies |
| EP0291636A1 (de) | 1983-11-07 | 1988-11-23 | The Wistar Institute | Von Anti-Idiotyp-Antikörpern induzierte Immunreaktion gegen Viren |
| US5180814A (en) | 1984-01-31 | 1993-01-19 | Akzo N.V. | Tumor specific monoclonal antibodies |
| US5106738A (en) | 1984-01-31 | 1992-04-21 | Akzo Nv | Tumor specific monoclonal antibodies |
| US4828991A (en) * | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
| US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US5160723A (en) | 1985-04-19 | 1992-11-03 | Sloan-Kettering Institute For Cancer Research | Method of imaging colorectal carcinoma lesion and composition for use therein |
| GB2202017A (en) * | 1987-03-07 | 1988-09-14 | Alvan Michael Judson | Anti-lock electric braking |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| JP2517343B2 (ja) * | 1988-01-26 | 1996-07-24 | 富士写真フイルム株式会社 | 熱現像感光材料 |
| JPH01207920A (ja) | 1988-02-16 | 1989-08-21 | Oki Electric Ind Co Ltd | InP半導体薄膜の製造方法 |
| GB8812137D0 (en) | 1988-05-23 | 1988-06-29 | Imp Cancer Res Tech | Antibodies |
| US5183756A (en) | 1988-08-19 | 1993-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibody (D612) having selective reactivity for gastrointestinal caricinomas and method for employing the same |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5407684A (en) | 1988-12-30 | 1995-04-18 | Virginia Commonwealth University | Use of DHEA as a medicinal |
| US5077284A (en) * | 1988-12-30 | 1991-12-31 | Loria Roger M | Use of dehydroepiandrosterone to improve immune response |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5244801A (en) | 1989-12-28 | 1993-09-14 | Martin Tobi | Process for producing monoclonal antibodies which specifically bind to benign colonic adenomatous polyps of human origin and hybridomas and monoclonal antibodies produced by said process |
| SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| US5200316A (en) | 1990-02-15 | 1993-04-06 | Miles Inc. | Immunoassay methods using noncross reactive cea gene family members antibodies |
| WO1991016924A1 (en) | 1990-05-10 | 1991-11-14 | The Dana-Farber Cancer Institute | Enhancing the association of exogenous peptides with class i mhc molecules on immune system cells |
| US5608039A (en) * | 1990-10-12 | 1997-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Single chain B3 antibody fusion proteins and their uses |
| GB9105992D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
| AU2690192A (en) | 1991-09-19 | 1993-04-27 | Lionel A. Manson | Tumor immunotherapy utilizing a method of overcoming the resistance of a progressively growing tumor |
| US5227471A (en) * | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
| WO1994005329A1 (en) | 1992-08-31 | 1994-03-17 | Jenner Technologies | Stimulation of an antitumor t-cell response using anti-idiotypic antibodies |
| ES2197217T3 (es) * | 1994-12-28 | 2004-01-01 | University Of Kentucky Research Foundation | Anticuerpo 3h1 monoclonal anti-id-murino. |
-
1995
- 1995-12-28 ES ES95944582T patent/ES2197217T3/es not_active Expired - Lifetime
- 1995-12-28 ES ES95944450T patent/ES2196098T3/es not_active Expired - Lifetime
- 1995-12-28 AU AU46927/96A patent/AU704829B2/en not_active Ceased
- 1995-12-28 PT PT95944582T patent/PT796280E/pt unknown
- 1995-12-28 CA CA2209360A patent/CA2209360C/en not_active Expired - Fee Related
- 1995-12-28 US US08/579,940 patent/US5977315A/en not_active Expired - Lifetime
- 1995-12-28 AT AT95944582T patent/ATE235514T1/de not_active IP Right Cessation
- 1995-12-28 DK DK95944582T patent/DK0796280T3/da active
- 1995-12-28 AT AT95944450T patent/ATE237687T1/de not_active IP Right Cessation
- 1995-12-28 WO PCT/US1995/017105 patent/WO1996020219A2/en not_active Ceased
- 1995-12-28 EP EP02014310A patent/EP1298144A3/de not_active Withdrawn
- 1995-12-28 DE DE69530107T patent/DE69530107T2/de not_active Expired - Fee Related
- 1995-12-28 AU AU46498/96A patent/AU717779C/en not_active Ceased
- 1995-12-28 CA CA002209172A patent/CA2209172C/en not_active Expired - Fee Related
- 1995-12-28 US US08/579,916 patent/US7090842B1/en not_active Expired - Fee Related
- 1995-12-28 JP JP8520610A patent/JPH10511846A/ja not_active Ceased
- 1995-12-28 DE DE69530415T patent/DE69530415T2/de not_active Expired - Fee Related
- 1995-12-28 JP JP8520611A patent/JPH11500607A/ja active Pending
- 1995-12-28 DK DK95944450T patent/DK0800578T3/da active
- 1995-12-28 WO PCT/US1995/017103 patent/WO1996020277A2/en not_active Ceased
- 1995-12-28 PT PT95944450T patent/PT800578E/pt unknown
- 1995-12-28 EP EP95944450A patent/EP0800578B1/de not_active Expired - Lifetime
- 1995-12-28 EP EP95944582A patent/EP0796280B1/de not_active Expired - Lifetime
-
1997
- 1997-06-27 MX MX9704897A patent/MX9704897A/es unknown
- 1997-06-27 MX MX9704898A patent/MX9704898A/es not_active Application Discontinuation
-
2001
- 2001-02-28 US US09/797,481 patent/US20010047083A1/en not_active Abandoned
Non-Patent Citations (9)
| Title |
|---|
| H. KOHLER ET AL.: "Idiotype manipulation in disease management.", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 383, 1995, NEW YORK, NY, USA, pages 117 - 122, XP000568725 * |
| K. FOON ET AL.: "Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine.", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 96, no. 1, July 1995 (1995-07-01), NEW YORK, NY, USA, pages 334 - 342, XP000568726 * |
| M. BHATTACHARYA-CHATTERJEE ET AL.: "Anti-idiotype monoclonal antibodies as vaccines for human cancer.", INTERNATIONAL REVIEWS OF IMMUNOLOGY, vol. 7, no. 4, 1991, LONDON, GB, pages 289 - 302, XP000568724 * |
| M. BHATTACHARYA-CHATTERJEE ET AL.: "Idiotype matching: A network antigen idiotype is expressed in sera of colon cancer patients.", VACCINE RESEARCH, vol. 2, no. 4, 1993, NEW YORK, NY, USA, pages 283 - 290, XP000568722 * |
| M. BHATTACHARYA-CHATTERJEE ET AL.: "Idiotypic antibody immunotherapy of cancer", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 38, no. 2, 1994, HEIDELBERG, GERMANY, pages 75 - 82, XP000568706 * |
| M. BHATTACHARYA-CHATTERJEE ET AL.: "Murine anti-idiotype (Id) monoclonal antibody (mAb) breaks tolerance and induces a specific antibody response to carcinoembryonic antigen (CEA) in colorectal cancer (CRC) patients.", THE FASEB JOURNAL, vol. 8, no. 4, 15 March 1994 (1994-03-15), BETHESDA, MD, USA, pages A200, XP002005756 * |
| M. BHATTACHARYA-CHATTERJEE ET AL.: "Murine monoclonal anti-idiotype antibody as a potential network antigen for human carcinoembryonic antigen.", THE JOURNAL OF IMMUNOLOGY, vol. 145, no. 8, 15 October 1990 (1990-10-15), BALTIMORE, MD, USA, pages 2758 - 2765, XP002005755 * |
| M. CHAKRABORTY ET AL.: "Preclinical evaluation in nonhuman primates of an anti-idiotype antibody that mimicks the carcinoembryonic antigen.", JOURNAL OF IMMUNOTHERAPY, vol. 18, no. 2, August 1995 (1995-08-01), PHILADELPHIA, PA, USA, pages 95 - 103, XP000568723 * |
| M. LOSMAN ET AL.: "Mimicry of a carcinoembryonic antigen epitope by a rat monoclonal anti-idiotype antibody.", INTERNATIONAL JOURNAL OF CANCER, vol. 56, no. 4, 15 February 1994 (1994-02-15), GENEVA, SWITZERLAND, pages 580 - 584, XP002005757 * |
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