EP1295642A1 - Zentrifuge - Google Patents
Zentrifuge Download PDFInfo
- Publication number
- EP1295642A1 EP1295642A1 EP02014477A EP02014477A EP1295642A1 EP 1295642 A1 EP1295642 A1 EP 1295642A1 EP 02014477 A EP02014477 A EP 02014477A EP 02014477 A EP02014477 A EP 02014477A EP 1295642 A1 EP1295642 A1 EP 1295642A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- line
- guide element
- separation unit
- contact surface
- centrifuge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000926 separation method Methods 0.000 claims abstract description 25
- 239000012530 fluid Substances 0.000 claims abstract description 8
- 238000007599 discharging Methods 0.000 claims abstract description 3
- 238000005299 abrasion Methods 0.000 abstract description 12
- 238000005452 bending Methods 0.000 description 7
- 239000013060 biological fluid Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012503 blood component Substances 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- FIKFLLIUPUVONI-UHFFFAOYSA-N 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one;hydrochloride Chemical compound Cl.O1C(=O)NCC11CCN(CCC=2C=CC=CC=2)CC1 FIKFLLIUPUVONI-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts
Definitions
- the invention relates to a centrifuge, in particular a gleitdichtungsschreib Centrifugal centrifuge for centrifuging biological fluids.
- Centrifuges are known in which the biological fluid flows through is centrifuged. Via a line, the fluid is a rotating Centrifuge chamber supplied or discharged from the chamber. Because of the Relative movement of the centrifuge chamber and fixed connection point of the However, the wiring proves to be problematic. To one To avoid twisting the pipe, see conventional Centrifuges at the connection points rotating seals Use. Although such flow centrifuges allow a high speed, however, the rotary joints can cause leaks and injuries lead of components contained in the fluid.
- a non-slip blood centrifuge is known from DE 32 42 541 A1.
- the Line is at the non-slip centrifuge of a stationary Connection point in a loop around the centrifuge chamber led around.
- the line is connected to a rotating frame, opposite to the Centrifuge chamber rotated at half speed.
- Such Flow centrifuge is also known for example from DE 42 20 232 A1.
- the line In the case of non-slip centrifugal flowmeters, the line is relatively large exposed to mechanical stresses that increase with increasing speed increase. Under the influence of the centrifugal forces the line forms one after externally sweeping loop, which at the fixed connection point and the Connection to the separation chamber high alternating bending loads occur. The steep entry and exit angle at the connection points leads to a additional friction between the Ranadaptem and the line, what in turn has an increased abrasion result.
- the alternating bending load and Abrasion are the factors that affect the life of the pipe or the maximum Limit the speed of the centrifuge.
- WO 95/17261 A1 describes a flow-through centrifuge whose Centrifuge tube is supported by a roller bearing, which on the Revolving frame is attached.
- the roller bearing which is made of the inner and outer Bearing shell with the rolling elements, is part of the line.
- a non-lubricated flow centrifuge that over a bearing for supporting the fluid line has, is also known from DE 198 03 535 A1 known.
- US-A-4 221 322 describes a flow-through centrifuge whose fluid conduit is itself supported on a rotationally symmetrical contact surface, which is a section which is formed by a rotating circular arc.
- US-A-4,111, 356 proposes a guide member for supporting the fluid line, the also has a rotationally symmetrical contact surface.
- the invention is based on the object, a particularly simple and To create inexpensive to produce centrifuge whose line for feeding and / or removal of the fluid is sufficiently supported on the one hand and on the other hand exposed to relatively low mechanical stresses is, so that high speeds are possible, the production of the line is particularly easy and inexpensive.
- the quotient of the respective radius of curvature R2 and the respective Distance R1 between the touch point and the axis of rotation should be over the course of the contact surface of the guide element descriptive curve be as constant as possible.
- the constant a R2 / R1 becomes strong of the used materials and the geometric boundary conditions. In particular, the bending stiffness of the line is important. It has shown that the service life can be increased in particular if 1 ⁇ a ⁇ 2 is.
- the guide element is a sleeve-shaped body enclosing the conduit.
- Both the guide element as well as the line are preferably made of abrasion resistant materials without Lubricants can easily slide on each other.
- the contact surface of the guide element closes at a particular preferred embodiment of a cylindrical guide section, the diameter of which is preferably such that the conduit is loose therein is guided.
- the cylindrical guide portion serves to guide a straight Section of the line, while the contact surface of the support of a adjoining bent line section serves.
- the centrifuge preferably has two for supporting the conduit Guide elements on.
- the first guide element is on the side of the Separation provided, which faces away from the fixed connection point.
- This guide element is made up of the separation unit extending line in a loop around the separation unit to the stationary Led connection, wherein the line with a first section at the Supported surface of the guide element.
- the second guide element which is provided at the fixed connection point, supports with its contact surface a second section of the Separation unit guided line.
- each Guide element may also be two of the contact surfaces of the invention have to support the line can.
- the flow centrifuge has a rotating frame 1 with a lower 1a and an upper support plate 1b and two side parts 1c, 1d.
- the rotating frame 1 is rotatably mounted on a stationary frame 2 about a vertical axis 3 and is driven by a drive unit, not shown in Fig. 1 at a rotational speed n 1 .
- a separation unit 4 in the form of a cylindrical chamber is rotatably supported about the rotation axis of the revolving frame 1.
- the separation unit 4 can also be attached to the underside of the support plate 1b.
- a flexible Line 6 in which one or more hoses for supplying and discharging the Blood or the blood components in the separation unit 4 or from her are summarized, led around the separation unit 4 and at her Bottom connected. Twisting of the line is thereby avoided that the line 6 at half the speed as the separation unit 4 to this is led around.
- the line 6 is part of a disposables, in addition to the separation unit 4 still bags for collecting the separated by the centrifugation Blood components includes.
- the disposable is inserted into the centrifuge and discarded after use.
- Such hose assemblies belong to State of the art, so that there is no need for further explanation here.
- a several collecting bag comprehensive Disposable is for example in the DE 28 45 364 A1 and DE 28 45 399 A1, to which expressly here Reference is made.
- a first is at the bottom of the separation unit Guide element 7 is provided, which has a first portion 6 a of the line. 6 supported.
- a second guide element 8 is provided at the fixed connection point 5 . Both Guide elements 7, 8 have an identical structure.
- the line with another Not shown guide element or bearing be attached.
- FIG. 2 shows a schematic diagram of one of the two guide elements 7, 8 of FIG Referring to Figure 1 described centrifuge in a sectional view.
- the guide element 7, 8 is a sleeve-shaped body, in particular made of ABS plastic. It has a rotationally symmetrical contact surface 10 for support a bent portion 11 of the conduit 6, at which a cylindrical Guide surface 12 for guiding a straight portion 13 of the line. 6 followed.
- the cylindrical guide surface 12 has a diameter which is slightly larger than the outer diameter of the conduit 6, so that the Line in the guide element is guided loose.
- the rotationally symmetrical contact surface 10 of the guide element 7, 8 is of a plane curve 15 rotating about the longitudinal axis 14 of the guide element formed, whose course is shown only schematically in Figure 2.
- the Longitudinal axis 14 of the guide element lies on the axis of rotation A of the Centrifuge.
- the abrasion A is proportional to the relative velocity V of the two rubbing surfaces and their surface pressure P.
- the relative speed is not constant, but proportional to the radial distance R1 to the central axis of rotation A of the centrifuge. V ⁇ R1
- Figure 3 shows the exact course of the contact surface descriptive curve. It Let it be assumed that the central axis of rotation A of the centrifuge through the Origin of the Cartesian coordinate system runs (y-axis).
- the radius R2 of the respective circle of curvature, the curve in one point touches, increases with increasing distance R1 between the touch point and the central axis of rotation.
- the circle of curvature that touches the curve at the point P i has the radius of curvature R 2i .
- the circle of curvature touching the curve at point P i + 1 has the radius R 2i + 1 .
- the contact point P i + 1 has a greater distance to the y-axis than the contact point P i . Consequently, the radius of curvature at point P i + 1 must be greater than the radius of curvature at point P i , which can be seen in FIG.
- the centers of the circles of curvature are designated M i in FIG.
Landscapes
- Centrifugal Separators (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims (8)
- Zentrifuge mit einem Drehrahmen (1), der an einem Gestell (2) drehbar gelagert ist, einer an dem Gestell gelagerten Separationseinheit (4), die mit doppelter Drehzahl in gleichem Drehsinn wie der Drehrahmen um eine zentrale Rotationsachse (A) drehbar ist, einer an der Separationseinheit angeschlossenen Leitung (6) zum Zuführen und/oder Abführen mindestens eines Fluids, die in einer Schleife um die Separationseinheit zu einer ortsfesten Anschlussstelle (5) geführt ist, und mindestens einem Führungselement (7, 8), das eine Anlagefläche (10) für die Leitung aufweist, an der sich die Leitung abstützt, wobei die Anlagefläche des Führungselements von einer rotierenden ebenen Kurve (15) gebildet wird, dadurch gekennzeichnet, daß der Radius R2 des jeweiligen Krümmungskreises, der die Kurve in einem Punkt (P) berührt, mit zunehmendem Abstand R1 zwischen dem Berührungspunkt und der zentralen Rotationsachse (A) zunimmt.
- Zentrifuge nach Anspruch 1, dadurch gekennzeichnet, dass die Quotienten (R1/R2) aus dem Krümmungsradius R2 und dem Abstand R1 zwischen dem Berührungspunkt (P) und der zentralen Rotationsachse (A) eine Konstante a sind.
- Zentrifuge nach Anspruch 2, dadurch gekennzeichnet, dass für die Konstante a 1 ≤ a ≤ 2 gilt.
- Zentrifuge nach einem der Ansprüche 1 - 3, dadurch gekennzeichnet, dass das Führungselement (7, 8) ein hülsenförmiger Körper ist.
- Zentrifuge nach einem der Ansprüche 1 - 4, dadurch gekennzeichnet, dass sich die Anlagefläche (10) des Führungselements (7, 8) an eine zylindrische Führungsfläche (12) anschließt.
- Zentrifuge nach Anspruch 5, dadurch gekennzeichnet, dass der Durchmesser der zylindrischen Führungsfläche (12) derart bemessen ist, dass die Leitung (6) in dem Führungselement (7, 8) lose geführt ist.
- Zentrifuge nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass ein erstes Führungselement (7) an der Seite der Separationseinheit (4) vorgesehen ist, die der ortsfesten Anschlussstelle (5) abgewandt ist, wobei die Leitung (6) mit einem ersten Abschnitt (6a) an der Anlagefläche (10) des ersten Führungselements abstützend um die Separationseinheit geführt ist.
- Zentrifuge nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass ein zweites Führungselement (8) an der ortsfesten Anschlussstelle (5) vorgesehen ist, wobei die Leitung (6) mit einem zweiten Abschnitt (6b) an der Anlagefläche (10) des zweiten Führungselements (8) abstützend um die Separationseinheit (4) geführt ist.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10142744A DE10142744C1 (de) | 2001-08-31 | 2001-08-31 | Zentrifuge |
DE10142744 | 2001-08-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1295642A1 true EP1295642A1 (de) | 2003-03-26 |
EP1295642B1 EP1295642B1 (de) | 2005-08-24 |
Family
ID=7697293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02014477A Expired - Lifetime EP1295642B1 (de) | 2001-08-31 | 2002-06-29 | Zentrifuge |
Country Status (6)
Country | Link |
---|---|
US (1) | US6716154B2 (de) |
EP (1) | EP1295642B1 (de) |
JP (1) | JP4255667B2 (de) |
AT (1) | ATE302650T1 (de) |
DE (2) | DE10142744C1 (de) |
ES (1) | ES2244702T3 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4321253A1 (de) * | 2022-08-09 | 2024-02-14 | Sigma Laborzentrifugen GmbH | Durchflusszentrifuge und ausgleichsrotor-führungseinrichtung |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7008366B1 (en) * | 2000-10-27 | 2006-03-07 | Zymequest, Inc. | Circumferentially driven continuous flow centrifuge |
DE10129769A1 (de) * | 2001-06-20 | 2003-01-09 | Fresenius Hemocare Gmbh | Schlauchanordnung und Verfahren zu ihrer Herstellung |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111356A (en) * | 1977-07-13 | 1978-09-05 | Baxter Travenol Laboratories, Inc. | Centrifugal apparatus with flexible sheath |
US4114802A (en) * | 1977-08-29 | 1978-09-19 | Baxter Travenol Laboratories, Inc. | Centrifugal apparatus with biaxial connector |
EP0619144A2 (de) * | 1993-04-03 | 1994-10-12 | Fresenius AG | Schlauchanordnordnung für eine gleitdichtungsfreie Zentrifuge |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE619144C (de) | 1935-09-23 | Josef Schleich | Eierbecher mit Koepfeinrichtung fuer gekochte Eier | |
US4113173A (en) * | 1975-03-27 | 1978-09-12 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus |
US4120448A (en) * | 1977-06-08 | 1978-10-17 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus with automatically positioned collection port |
US4164318A (en) * | 1977-10-12 | 1979-08-14 | Baxter Travenol Laboratories, Inc. | Centrifugal processing apparatus with reduced-load tubing |
US4146172A (en) * | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
US4185629A (en) * | 1977-10-18 | 1980-01-29 | Baxter Travenol Laboratories, Inc. | Method and apparatus for processing blood |
US4109852A (en) * | 1977-10-21 | 1978-08-29 | Baxter Travenol Laboratories, Inc. | Centrifugal strain relief sheath for processing apparatus |
US4221322A (en) * | 1977-10-31 | 1980-09-09 | Union Carbide Corporation | Tube guide insert and constraint fittings for compensating rotor |
DE3242541A1 (de) * | 1982-11-18 | 1984-05-24 | Fresenius AG, 6380 Bad Homburg | Zentrifuge |
US4439178A (en) * | 1982-12-30 | 1984-03-27 | International Business Machines Corporation | Sealless centrifuge processing channel and tube system |
JPS61245855A (ja) * | 1985-04-22 | 1986-11-01 | Green Cross Corp:The | 連続式血液分離装置 |
AU652888B2 (en) * | 1991-12-23 | 1994-09-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
DE4220232A1 (de) * | 1992-06-20 | 1993-12-23 | Fresenius Ag | Zentrifuge |
US5514069A (en) * | 1993-12-22 | 1996-05-07 | Baxter International Inc. | Stress-bearing umbilicus for a compact centrifuge |
US5704887A (en) * | 1995-06-07 | 1998-01-06 | Baxter International Inc. | Easy load umbilicus holder for a centrifuge |
US5989177A (en) * | 1997-04-11 | 1999-11-23 | Baxter International Inc. | Umbilicus gimbal with bearing retainer |
US6344020B1 (en) * | 1997-04-11 | 2002-02-05 | Baxter International Inc. | Bearing and umbilicus gimbal with bearing retainer in blood processing system |
DE19803534C2 (de) * | 1998-01-30 | 1999-11-11 | Fresenius Ag | Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle |
DE19803535C2 (de) * | 1998-01-30 | 1999-11-18 | Fresenius Ag | Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle |
-
2001
- 2001-08-31 DE DE10142744A patent/DE10142744C1/de not_active Expired - Fee Related
-
2002
- 2002-06-29 ES ES02014477T patent/ES2244702T3/es not_active Expired - Lifetime
- 2002-06-29 DE DE50204009T patent/DE50204009D1/de not_active Expired - Lifetime
- 2002-06-29 EP EP02014477A patent/EP1295642B1/de not_active Expired - Lifetime
- 2002-06-29 AT AT02014477T patent/ATE302650T1/de not_active IP Right Cessation
- 2002-08-27 US US10/228,553 patent/US6716154B2/en not_active Expired - Lifetime
- 2002-09-02 JP JP2002257123A patent/JP4255667B2/ja not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111356A (en) * | 1977-07-13 | 1978-09-05 | Baxter Travenol Laboratories, Inc. | Centrifugal apparatus with flexible sheath |
US4114802A (en) * | 1977-08-29 | 1978-09-19 | Baxter Travenol Laboratories, Inc. | Centrifugal apparatus with biaxial connector |
EP0619144A2 (de) * | 1993-04-03 | 1994-10-12 | Fresenius AG | Schlauchanordnordnung für eine gleitdichtungsfreie Zentrifuge |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4321253A1 (de) * | 2022-08-09 | 2024-02-14 | Sigma Laborzentrifugen GmbH | Durchflusszentrifuge und ausgleichsrotor-führungseinrichtung |
WO2024033255A1 (de) | 2022-08-09 | 2024-02-15 | Sartorius Stedim North America Inc. | Durchflusszentrifuge und ausgleichsrotor-führungseinrichtung |
Also Published As
Publication number | Publication date |
---|---|
DE50204009D1 (de) | 2005-09-29 |
JP2003159324A (ja) | 2003-06-03 |
EP1295642B1 (de) | 2005-08-24 |
ATE302650T1 (de) | 2005-09-15 |
US20030045419A1 (en) | 2003-03-06 |
JP4255667B2 (ja) | 2009-04-15 |
DE10142744C1 (de) | 2003-05-22 |
ES2244702T3 (es) | 2005-12-16 |
US6716154B2 (en) | 2004-04-06 |
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