Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/28—Zirconium; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/26—Aluminium; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants

Definitions

• the present invention relates to the use, in the preparation of cosmetic compositions, of divalent manganese salts as odor reducing agents resulting from the decomposition by bacteria of human sweat.
• It also relates to a process for reducing human body odors resulting from their bacterial decomposition, consisting in applying to the axillary surface, the scalp or the feet, an effective amount of a divalent manganese salt.
• Body odors result from the metabolism of compounds present on the skin or scalp, by microorganisms of the resident body flora.
• the literature gives indications on the main types of microorganisms responsible for the appearance of bad body odors, and on the main chemical families constituting these.
• diphtheroids with lipolytic activity appear to be the most frequently cited types of bacteria, with in particular Corynebacterium xerosis for axillary odors, and Propionibacterium acnes for odors in the feet and scalp.
• a yeast, Pityrosporum ovale also appears to contribute to the development of the odor.
• Antiperspirants have the effect of limiting sweat flow. They generally consist of aluminum salts which, on the one hand, are irritants for the skin and which, on the other hand, decrease the sweat flow by modifying the cutaneous physiology, which is not satisfactory.
• Triclosan (2,4,4'-trichloro-2'-hydroxydiphenylether), which has the drawback of significantly modifying the ecology of the skin flora, of being inhibited by certain compounds, such as, for example, nonionic surfactants, commonly used in the formulation of cosmetic compositions.
• certain compounds such as, for example, nonionic surfactants, commonly used in the formulation of cosmetic compositions.
• the insoluble nature of Triclosan in water does not allow its incorporation into essentially aqueous formulas.
• divalent manganese salts have the property of reducing the odors of perspiration from the armpits and feet, and the odors of the scalp, without the drawbacks of the active substances previously used in deodorant compositions, and with the advantage, for some of these compounds, of being water-soluble in advantageous and sufficient proportions to be easily formulated, in particular in water-based cosmetic compositions for human topical application.
• the present invention thus has for first object, the use of divalent manganese salts as agents reducing the intensity of the odor of human sweat decomposed by bacteria, in a cosmetic composition.
• Its second object is a process for reducing human body odors resulting from their decomposition by bacteria, consisting in applying to the axillary surface, feet or scalp an effective amount of a divalent manganese salt.
• Its third object is a cosmetic composition intended to be applied to human skin, comprising in a cosmetically acceptable vehicle, at least one antiperspirant or deodorant active agent and, in addition, at least one divalent manganese salt as reducing agent for l intensity of the smell of human sweat broken down by bacteria, and for other purposes also the use of said composition, in, or for the manufacture of, antiperspirant or deodorant cosmetic products intended for human topical application.
• water-soluble manganese salts is understood to mean manganese salts of organic or mineral acids whose solubility in water, expressed as a percentage by weight of Mn ion, is greater than or equal to 0.3.
• Particularly preferred water-soluble manganese salts according to the present invention are manganese chloride, manganese acetate, manganese sulfate.
• manganese chloride (MnCl2) manganese chloride (MnCl2).
• the water-soluble salts of divalent manganese in comparison with Triclosan well known in the field under consideration, have the advantage of being more effective in reducing the intensity and the unpleasantness of the odor and being odorless at use concentrations.
• the divalent manganese salts according to the invention preferably represent from 0.01 to 20% by weight approximately of the total weight of the cosmetic composition, more particularly from 0.1 to 10%, and even more preferably from 0.1 to 5% by weight approximately. weight.
• the deodorant active agents can be chosen for example from: water-soluble zinc salts, such as for example zinc pyrrolidone carboxylate (more commonly called zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, gluconate zinc and zinc phenoisuifonate; other non-water-soluble zinc compounds such as, for example, zinc ricinoleate; bactericides such as 2,4,4'-trichloro-2'-hydroxydiphenylether (Triclosan), or 3,7,11-trimethyldodeca-2,5,10-thenol (Farnesol).
• water-soluble zinc salts such as for example zinc pyrrolidone carboxylate (more commonly called zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, gluconate zinc and zinc phenoisuifonate
• other non-water-soluble zinc compounds such as, for example, zinc ricinoleate
• bactericides such as 2,4,4'-t
• deodorant active agents can be present in the composition according to the invention in an amount of about 0.001 to 20% by weight relative to the total composition, and preferably in an amount of about 0.1 to 5% by weight.
• the cosmetic composition according to the invention is conventionally formulated according to the form of presentation for which it is intended.
• a cosmetically acceptable vehicle which can in particular be essentially aqueous, or contain organic solvents and in particular CC monoalcohols, preferably ethanol to accelerate the evaporation of the product, or propylene glycol, dipropylene glycol or their ethers.
• the cosmetic composition according to the invention can also be formulated as a water-in-oil emulsion, oil-in-water, or as a triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C. FOX in "Cosmetics and Toiletries” - November 1986 - Vol 101 - pages 101-112).
• the cosmetic composition of the invention may also comprise cosmetic adjuvants chosen from fatty substances, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, anti-foaming agents, moisturizing agents, vitamins , perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics for this type of application.
• cosmetic adjuvants chosen from fatty substances, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, anti-foaming agents, moisturizing agents, vitamins , perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics for this type of application.
• the surfactants are preferably chosen from anionic, amphoteric or nonionic surfactants.
• the fatty substances can consist of an oil or a wax or a mixture thereof, petrolatum, paraffin, lanolin, hydrogenated lanolin, acetylated lanolin; they also include fatty acids, fatty alcohols such as lauric, cetyl, myristic, stearic, palmitic, oleic alcohol as well as 2-octyldodecanol, fatty acid esters such as glycerol monostearate, polyethylene glycol monostearate , isopropyl myristate, isopropyl adipate, isopropyl palmitate, octyl palmitate, benzoates fatty alcohols in C-12-C15 (Finsolv TN from FINETEX), myristic polyoxypropylenated alcohol with 3 moles of propylene oxide (WITCONOL APM from WITCO), triglycerides of fatty acids in CQ-C- Q such than caprylic / capric acid triglycer
• the waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. Mention may in particular bees beeswaxes, Carnauba, Candelila, sugar cane, Japanese waxes, ozokerites, Montan wax, microcrystalline waxes, paraffins, waxes and silicone resins.
• the thickeners preferably nonionic, can be chosen from guar gums and modified or unmodified celluloses such as hydroxypropylated guar gum, cetylhydroxyethylcellulose, silicas such as, for example, Bentone Gel MiO sold by the company NL INDUSTRIES or
• Veegum Ultra sold by the company POLYPLASTIC.
• the cosmetic composition can comprise emollients, which contribute to a soft, dry feeling, non-sticky when the composition is applied to the skin.
• emollients can be chosen from products of the volatile silicone type, non-volatile silicones and other non-volatile emollients.
• Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type, the chains of which comprise from 3 to 9 silicone residues.
• cyclomethicones D4 or D5 are chosen.
• Non-volatile silicones are defined in a known manner as compounds with low vapor pressure at room temperature.
• polyalkylsiloxanes in particular linear polyalkylsiloxanes such as, for example, linear polydimethylsiloxanes, or dimethicones, sold by the company Dow Corning under the name of "Dow Corning 200 Fluid”
• polyalkylarylsiloxanes such as for example polymethylphenylsiloxanes, sold by the company Dow Corning under the name of "Dow Corning 556 Fluid”
• polyether and siloxane copolymers such as, for example, dimethicone copolyols.
• nonvolatile emollients useful in the present invention include for example: hydrocarbon-based derivatives, mineral oils, fatty alcohols, alcohol esters of C 3 -C ⁇ 8 with C 3 -C acids ⁇ s, benzoic acid esters with C ⁇ 2 -C ⁇ alcohols and their mixtures, C 2 -C 6 polyols preferably chosen from glycerol, propylene glycol or sorbitol, polymers of polalkylene glycol.
• the amounts of these various constituents which may be present in the cosmetic composition according to the invention are those conventionally used for the forms of presentation considered.
• composition according to the invention can thus be in the form of a lotion, cream or fluid gel distributed in aerosol spray, in pump bottle or in roll-on, in the form of thick cream distributed in tube and in the form of stick or powder, and contain in this regard the ingredients and propellants generally used in this type of product and well known to those skilled in the art.
• a test of inhibition of the evolution of odors was carried out on natural sweat.
• the principle of this test consists in adding the deodorant agent to the fresh sweat, then in carrying out an olfactory evaluation by a jury of experts after 18 hours then 24 hours of incubation at 37 ° C.
• Each of the 2 compounds was presented in the form of an ethanolic solution, MnCl2 at 10% Active material (MA) and Triclosan at 1% MA.
• One hundred ⁇ l of the ethanolic solution was added to 0.9 ml of agar culture by supercooling at 45 ° C. (medium chosen according to the nutritional requirements of the strain studied). After Vortex stirring, successive dilutions, in geometric progression of reason 2, of the solution obtained were carried out using the agar culture medium in supercooling at 45 ° C. One ml of each dilution was introduced into the wells of a microplate (bottle, 24 wells). Four ⁇ l of microbial suspension were deposited on the surface of the agar medium.
• MIC Minimum Inhibitory Concentration

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• Cosmetics (AREA)

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• 2000
  • 2000-04-18 FR FR0004995A patent/FR2807655B1/fr not_active Expired - Lifetime
• 2001
  • 2001-04-11 WO PCT/FR2001/001111 patent/WO2001078658A2/fr not_active Application Discontinuation
  • 2001-04-11 AU AU2001250484A patent/AU2001250484A1/en not_active Abandoned
  • 2001-04-11 EP EP01923796A patent/EP1276454A2/de not_active Withdrawn

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