EP1276454A2 - Divalent manganese salts for reducing odour resulting from bacterial decomposition of human perspiration - Google Patents

Divalent manganese salts for reducing odour resulting from bacterial decomposition of human perspiration

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Publication number
EP1276454A2
EP1276454A2 EP01923796A EP01923796A EP1276454A2 EP 1276454 A2 EP1276454 A2 EP 1276454A2 EP 01923796 A EP01923796 A EP 01923796A EP 01923796 A EP01923796 A EP 01923796A EP 1276454 A2 EP1276454 A2 EP 1276454A2
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EP
European Patent Office
Prior art keywords
divalent manganese
composition
water
manganese salt
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP01923796A
Other languages
German (de)
French (fr)
Inventor
Christophe Courbiere
Serge Forestier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
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Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Publication of EP1276454A2 publication Critical patent/EP1276454A2/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/28—Zirconium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • the present invention relates to the use, in the preparation of cosmetic compositions, of divalent manganese salts as odor reducing agents resulting from the decomposition by bacteria of human sweat.
  • It also relates to a process for reducing human body odors resulting from their bacterial decomposition, consisting in applying to the axillary surface, the scalp or the feet, an effective amount of a divalent manganese salt.
  • Body odors result from the metabolism of compounds present on the skin or scalp, by microorganisms of the resident body flora.
  • the literature gives indications on the main types of microorganisms responsible for the appearance of bad body odors, and on the main chemical families constituting these.
  • diphtheroids with lipolytic activity appear to be the most frequently cited types of bacteria, with in particular Corynebacterium xerosis for axillary odors, and Propionibacterium acnes for odors in the feet and scalp.
  • a yeast, Pityrosporum ovale also appears to contribute to the development of the odor.
  • Antiperspirants have the effect of limiting sweat flow. They generally consist of aluminum salts which, on the one hand, are irritants for the skin and which, on the other hand, decrease the sweat flow by modifying the cutaneous physiology, which is not satisfactory.
  • Triclosan (2,4,4'-trichloro-2'-hydroxydiphenylether), which has the drawback of significantly modifying the ecology of the skin flora, of being inhibited by certain compounds, such as, for example, nonionic surfactants, commonly used in the formulation of cosmetic compositions.
  • certain compounds such as, for example, nonionic surfactants, commonly used in the formulation of cosmetic compositions.
  • the insoluble nature of Triclosan in water does not allow its incorporation into essentially aqueous formulas.
  • divalent manganese salts have the property of reducing the odors of perspiration from the armpits and feet, and the odors of the scalp, without the drawbacks of the active substances previously used in deodorant compositions, and with the advantage, for some of these compounds, of being water-soluble in advantageous and sufficient proportions to be easily formulated, in particular in water-based cosmetic compositions for human topical application.
  • the present invention thus has for first object, the use of divalent manganese salts as agents reducing the intensity of the odor of human sweat decomposed by bacteria, in a cosmetic composition.
  • Its second object is a process for reducing human body odors resulting from their decomposition by bacteria, consisting in applying to the axillary surface, feet or scalp an effective amount of a divalent manganese salt.
  • Its third object is a cosmetic composition intended to be applied to human skin, comprising in a cosmetically acceptable vehicle, at least one antiperspirant or deodorant active agent and, in addition, at least one divalent manganese salt as reducing agent for l intensity of the smell of human sweat broken down by bacteria, and for other purposes also the use of said composition, in, or for the manufacture of, antiperspirant or deodorant cosmetic products intended for human topical application.
  • water-soluble manganese salts is understood to mean manganese salts of organic or mineral acids whose solubility in water, expressed as a percentage by weight of Mn ion, is greater than or equal to 0.3.
  • Particularly preferred water-soluble manganese salts according to the present invention are manganese chloride, manganese acetate, manganese sulfate.
  • manganese chloride (MnCl2) manganese chloride (MnCl2).
  • the water-soluble salts of divalent manganese in comparison with Triclosan well known in the field under consideration, have the advantage of being more effective in reducing the intensity and the unpleasantness of the odor and being odorless at use concentrations.
  • the divalent manganese salts according to the invention preferably represent from 0.01 to 20% by weight approximately of the total weight of the cosmetic composition, more particularly from 0.1 to 10%, and even more preferably from 0.1 to 5% by weight approximately. weight.
  • the deodorant active agents can be chosen for example from: water-soluble zinc salts, such as for example zinc pyrrolidone carboxylate (more commonly called zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, gluconate zinc and zinc phenoisuifonate; other non-water-soluble zinc compounds such as, for example, zinc ricinoleate; bactericides such as 2,4,4'-trichloro-2'-hydroxydiphenylether (Triclosan), or 3,7,11-trimethyldodeca-2,5,10-thenol (Farnesol).
  • water-soluble zinc salts such as for example zinc pyrrolidone carboxylate (more commonly called zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, gluconate zinc and zinc phenoisuifonate
  • other non-water-soluble zinc compounds such as, for example, zinc ricinoleate
  • bactericides such as 2,4,4'-t
  • deodorant active agents can be present in the composition according to the invention in an amount of about 0.001 to 20% by weight relative to the total composition, and preferably in an amount of about 0.1 to 5% by weight.
  • the cosmetic composition according to the invention is conventionally formulated according to the form of presentation for which it is intended.
  • a cosmetically acceptable vehicle which can in particular be essentially aqueous, or contain organic solvents and in particular CC monoalcohols, preferably ethanol to accelerate the evaporation of the product, or propylene glycol, dipropylene glycol or their ethers.
  • the cosmetic composition according to the invention can also be formulated as a water-in-oil emulsion, oil-in-water, or as a triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C. FOX in "Cosmetics and Toiletries” - November 1986 - Vol 101 - pages 101-112).
  • the cosmetic composition of the invention may also comprise cosmetic adjuvants chosen from fatty substances, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, anti-foaming agents, moisturizing agents, vitamins , perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics for this type of application.
  • cosmetic adjuvants chosen from fatty substances, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, anti-foaming agents, moisturizing agents, vitamins , perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics for this type of application.
  • the surfactants are preferably chosen from anionic, amphoteric or nonionic surfactants.
  • the fatty substances can consist of an oil or a wax or a mixture thereof, petrolatum, paraffin, lanolin, hydrogenated lanolin, acetylated lanolin; they also include fatty acids, fatty alcohols such as lauric, cetyl, myristic, stearic, palmitic, oleic alcohol as well as 2-octyldodecanol, fatty acid esters such as glycerol monostearate, polyethylene glycol monostearate , isopropyl myristate, isopropyl adipate, isopropyl palmitate, octyl palmitate, benzoates fatty alcohols in C-12-C15 (Finsolv TN from FINETEX), myristic polyoxypropylenated alcohol with 3 moles of propylene oxide (WITCONOL APM from WITCO), triglycerides of fatty acids in CQ-C- Q such than caprylic / capric acid triglycer
  • the waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. Mention may in particular bees beeswaxes, Carnauba, Candelila, sugar cane, Japanese waxes, ozokerites, Montan wax, microcrystalline waxes, paraffins, waxes and silicone resins.
  • the thickeners preferably nonionic, can be chosen from guar gums and modified or unmodified celluloses such as hydroxypropylated guar gum, cetylhydroxyethylcellulose, silicas such as, for example, Bentone Gel MiO sold by the company NL INDUSTRIES or
  • Veegum Ultra sold by the company POLYPLASTIC.
  • the cosmetic composition can comprise emollients, which contribute to a soft, dry feeling, non-sticky when the composition is applied to the skin.
  • emollients can be chosen from products of the volatile silicone type, non-volatile silicones and other non-volatile emollients.
  • Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type, the chains of which comprise from 3 to 9 silicone residues.
  • cyclomethicones D4 or D5 are chosen.
  • Non-volatile silicones are defined in a known manner as compounds with low vapor pressure at room temperature.
  • polyalkylsiloxanes in particular linear polyalkylsiloxanes such as, for example, linear polydimethylsiloxanes, or dimethicones, sold by the company Dow Corning under the name of "Dow Corning 200 Fluid”
  • polyalkylarylsiloxanes such as for example polymethylphenylsiloxanes, sold by the company Dow Corning under the name of "Dow Corning 556 Fluid”
  • polyether and siloxane copolymers such as, for example, dimethicone copolyols.
  • nonvolatile emollients useful in the present invention include for example: hydrocarbon-based derivatives, mineral oils, fatty alcohols, alcohol esters of C 3 -C ⁇ 8 with C 3 -C acids ⁇ s, benzoic acid esters with C ⁇ 2 -C ⁇ alcohols and their mixtures, C 2 -C 6 polyols preferably chosen from glycerol, propylene glycol or sorbitol, polymers of polalkylene glycol.
  • the amounts of these various constituents which may be present in the cosmetic composition according to the invention are those conventionally used for the forms of presentation considered.
  • composition according to the invention can thus be in the form of a lotion, cream or fluid gel distributed in aerosol spray, in pump bottle or in roll-on, in the form of thick cream distributed in tube and in the form of stick or powder, and contain in this regard the ingredients and propellants generally used in this type of product and well known to those skilled in the art.
  • a test of inhibition of the evolution of odors was carried out on natural sweat.
  • the principle of this test consists in adding the deodorant agent to the fresh sweat, then in carrying out an olfactory evaluation by a jury of experts after 18 hours then 24 hours of incubation at 37 ° C.
  • Each of the 2 compounds was presented in the form of an ethanolic solution, MnCl2 at 10% Active material (MA) and Triclosan at 1% MA.
  • One hundred ⁇ l of the ethanolic solution was added to 0.9 ml of agar culture by supercooling at 45 ° C. (medium chosen according to the nutritional requirements of the strain studied). After Vortex stirring, successive dilutions, in geometric progression of reason 2, of the solution obtained were carried out using the agar culture medium in supercooling at 45 ° C. One ml of each dilution was introduced into the wells of a microplate (bottle, 24 wells). Four ⁇ l of microbial suspension were deposited on the surface of the agar medium.
  • MIC Minimum Inhibitory Concentration

Abstract

The invention concerns, for the preparation of cosmetic compositions, the use of divalent manganese salts as agents for reducing odour resulting from bacterial decomposition of human perspiration. The invention also concerns a method for reducing human body odours resulting from their bacterial decomposition and in particular axillary odours, foot odours and scalp odours.

Description

SELS DE MANGANESE DIVALENT POUR REDUIRE L'ODEUR RESULTANT DE LA DECOMPOSITION BACTERIENNE DE LA SUEUR HUMAINE DIVALENT MANGANESE SALTS TO REDUCE THE ODOR RESULTING FROM BACTERIAL DECOMPOSITION OF HUMAN SWEAT
La présente invention a pour objet l'utilisation, dans la préparation de compositions cosmétiques, de sels de manganèse divalent comme agents réducteurs de l'odeur résultant de la décomposition par les bactéries de la sueur humaine.The present invention relates to the use, in the preparation of cosmetic compositions, of divalent manganese salts as odor reducing agents resulting from the decomposition by bacteria of human sweat.
Elle concerne également un procédé pour réduire les odeurs corporelles humaines résultant de leur décomposition bactérienne consistant à appliquer sur la surface axillaire, le cuir chevelu ou les pieds, une quantité efficace d'un sel de manganèse divalent.It also relates to a process for reducing human body odors resulting from their bacterial decomposition, consisting in applying to the axillary surface, the scalp or the feet, an effective amount of a divalent manganese salt.
Les odeurs corporelles résultent de la métabolisation de composés présents sur la peau ou le cuir chevelu, par des micro-organismes de la flore corporelle résidente. La littérature donne des indications sur les principaux types de microorganismes responsables de l'apparition des mauvaises odeurs corporelles, et sur les principales familles chimiques constitutives de ces dernières. Ainsi, les diphtéroïdes à activité lipolytique apparaissent comme les types de bactéries les plus fréquemment citées, avec notamment Corynebacterium xerosis pour les odeurs axillaires, et Propionibacterium acnés pour les odeurs des pieds et du cuir chevelu. Sur cette dernière région corporelle, une levure, Pityrosporum ovale, apparaît également contribuer au développement de l'odeur.Body odors result from the metabolism of compounds present on the skin or scalp, by microorganisms of the resident body flora. The literature gives indications on the main types of microorganisms responsible for the appearance of bad body odors, and on the main chemical families constituting these. Thus, diphtheroids with lipolytic activity appear to be the most frequently cited types of bacteria, with in particular Corynebacterium xerosis for axillary odors, and Propionibacterium acnes for odors in the feet and scalp. In this latter region of the body, a yeast, Pityrosporum ovale, also appears to contribute to the development of the odor.
Quant aux principales familles de composés malodorants, il s'agirait d'acides gras à chaîne courte C3-C10 (odeurs des aisselles et des pieds) ; de 16-androstènes - stéroïdes volatils en Cι7 - (odeurs axillaires) ; et de lactones (odeurs du cuir chevelu).As for the main families of smelly compounds, they are short chain fatty acids C 3 -C 10 (armpits and feet odors); 16-androstenes - volatile steroids in Cι 7 - (axillary odors); and lactones (odors from the scalp).
Dans le domaine cosmétique, il est bien connu d'utiliser en application topique, des produits contenant des substances actives de type antitranspirant ou de type bactéricide.In the cosmetic field, it is well known to use, in topical application, products containing active substances of antiperspirant type or of bactericidal type.
Les substances antitranspirantes ont pour effet de limiter le flux sudoral. Elles sont généralement constituées de sels d'aluminium qui, d'une part, sont irritants pour la peau et qui, d'autre part, diminuent le flux sudoral en modifiant la physiologie cutanée, ce qui n'est pas satisfaisant.Antiperspirants have the effect of limiting sweat flow. They generally consist of aluminum salts which, on the one hand, are irritants for the skin and which, on the other hand, decrease the sweat flow by modifying the cutaneous physiology, which is not satisfactory.
Les substances bactéricides inhibent le développement de la flore cutanée responsable des odeurs axillaires. Parmi les produits bactéricides, le plus couramment employé est le Triclosan (2,4,4'-trichloro-2'-hydroxydiphényléther), qui présente l'inconvénient de modifier de façon importante l'écologie de la flore cutanée, d'être inhibé par certains composés, comme par exemple les tensio- actifs non-ioniques, couramment utilisés dans la formulation de compositions cosmétiques. Par ailleurs, le caractère insoluble du Triclosan dans l'eau ne permet pas son incorporation dans des formules essentiellement aqueuses.Bactericidal substances inhibit the development of the skin flora responsible for axillary odors. Among the bactericidal products, the most commonly used is Triclosan (2,4,4'-trichloro-2'-hydroxydiphenylether), which has the drawback of significantly modifying the ecology of the skin flora, of being inhibited by certain compounds, such as, for example, nonionic surfactants, commonly used in the formulation of cosmetic compositions. Furthermore, the insoluble nature of Triclosan in water does not allow its incorporation into essentially aqueous formulas.
Dans le but d'obtenir une efficacité à long terme, on recherche de nouveaux produits qui soient capables de modifier, de réduire et/ou d'ôter ou de prévenir le développement des odeurs corporelles (cette définition est donnée dans l'ouvrage « Cosmetic Science and Technology Séries » - 1988 / Volume 7 chap.10 - lllc). En outre, on recherche des produits qui ne présentent pas les inconvénients des substances actives utilisées dans l'art antérieur.In order to obtain long-term efficacy, we are looking for new products that are capable of modifying, reducing and / or removing or preventing the development of body odors (this definition is given in the book “Cosmetic Science and Technology Series ”- 1988 / Volume 7 chap.10 - lllc). In addition, products are sought which do not have the drawbacks of the active substances used in the prior art.
Dans le brevet US-5 788 956, on a décrit un procédé pour prévenir ou contrôler le flux sudoral cutané chez l'être humain, qui consiste à utiliser comme agent antitranspirant, des antagonistes de substances P dont on cite notamment des sels de manganèse ou de magnésium.In patent US Pat. No. 5,788,956, a process has been described for preventing or controlling the cutaneous sweat flow in humans, which consists in using as antiperspirant agents, antagonists of substances P, in which manganese salts or magnesium.
Ce document ne décrit ni ne suggère d'utiliser un sel divalent de manganèse pour réduire l'odeur désagréable résultant de la dégradation bactérienne de la sueur humaine.This document neither describes nor suggests using a divalent manganese salt to reduce the unpleasant odor resulting from the bacterial breakdown of human sweat.
Dans la demande de brevet WO 96/29049, on a déjà préconisé d'utiliser en cosmétique, dans des compositions de nettoyage pour la peau, des cations polyvalents dont notamment le manganèse, comme agents antimicrobiens efficaces sur le germe pathogène Staphylococcus aureus. Cependant, cette bactérie ne fait pas partie de la flore cutanée résidente, et n'apparaît pas comme un des principaux germes impliqués dans la formation des odeurs corporelles. Dans la demande de brevet EP-713695, on a décrit un procédé pour la déformation permanente des cheveux, au cours duquel les sels de manganèse ont pour effet, notamment, de neutraliser l'odeur des mercaptans dégagés pendant la phase de réduction. Cependant, ce document ne décrit ni ne suggère d'utiliser lesdits sels pour neutraliser l'odeur des acides gras, stéroïdes et lactones, à l'origine des composés corporels malodorants.In patent application WO 96/29049, it has already been recommended to use in cosmetics, in cleaning compositions for the skin, polyvalent cations including in particular manganese, as effective antimicrobial agents on the pathogenic germ Staphylococcus aureus. However, this bacteria is not part of the resident skin flora, and does not appear as one of the main germs involved in the formation of body odors. In patent application EP-713695, a process has been described for the permanent deformation of the hair, during which the manganese salts have the effect, in particular, of neutralizing the odor of the mercaptans released during the reduction phase. However, this document neither describes nor suggests using said salts to neutralize the odor of fatty acids, steroids and lactones, which are the source of malodorous body compounds.
Après de nombreuses recherches menées sur la question, la Demanderesse a maintenant découvert, de façon inattendue et surprenante, que les sels de manganèse divalent, présentent la propriété de réduire les odeurs de transpiration des aisselles et des pieds, et les odeurs du cuir chevelu, sans les inconvénients des substances actives antérieurement employées dans les compositions déodorantes, et avec l'avantage, pour certains de ces composés, d'être hydrosolubles dans des proportions intéressantes et suffisantes pour être aisément formulables, notamment dans les compositions cosmétiques à base d'eau pour l'application topique humaine.After numerous researches conducted on the question, the Applicant has now discovered, unexpectedly and surprisingly, that divalent manganese salts have the property of reducing the odors of perspiration from the armpits and feet, and the odors of the scalp, without the drawbacks of the active substances previously used in deodorant compositions, and with the advantage, for some of these compounds, of being water-soluble in advantageous and sufficient proportions to be easily formulated, in particular in water-based cosmetic compositions for human topical application.
Cette découverte est à la base de la présente invention.This discovery is the basis of the present invention.
La présente invention a ainsi pour premier objet, l'utilisation de sels de manganèse divalent comme agents réducteurs de l'intensité de l'odeur de sueur humaine décomposée par les bactéries, dans une composition cosmétique.The present invention thus has for first object, the use of divalent manganese salts as agents reducing the intensity of the odor of human sweat decomposed by bacteria, in a cosmetic composition.
Elle a pour second objet, un procédé pour réduire les odeurs corporelles humaines résultant de leur décomposition par les bactéries, consistant à appliquer sur la surface axillaire, des pieds ou du cuir chevelu une quantité efficace d'un sel de manganèse divalent.Its second object is a process for reducing human body odors resulting from their decomposition by bacteria, consisting in applying to the axillary surface, feet or scalp an effective amount of a divalent manganese salt.
Elle a pour troisième objet une composition cosmétique destinée à être appliquée sur la peau humaine, comprenant dans un véhicule cosmétiquement acceptable, au moins un actif antitranspirant ou déodorant et en outre, au moins un sel de manganèse divalent à titre d'agent réducteur de l'intensité de l'odeur de sueur humaine décomposée par les bactéries, et pour autre objet également l'utilisation de ladite composition, dans des, ou pour la fabrication de, produits cosmétiques antitranspirants ou déodorants destinés à l'application topique humaine.Its third object is a cosmetic composition intended to be applied to human skin, comprising in a cosmetically acceptable vehicle, at least one antiperspirant or deodorant active agent and, in addition, at least one divalent manganese salt as reducing agent for l intensity of the smell of human sweat broken down by bacteria, and for other purposes also the use of said composition, in, or for the manufacture of, antiperspirant or deodorant cosmetic products intended for human topical application.
Au sens de la présente invention, on entend par sels hydrosolubles de manganèse des sels de manganèse d'acides organiques ou minéraux dont la solubilité dans l'eau, exprimée en pourcentage pondéral d'ion Mn, est supérieure ou égale à 0.3 . Des sels hydrosolubles de manganèse particulièrement préférés selon la présente invention sont le chlorure de manganèse, l'acétate de manganèse, le sulfate de manganèse. Parmi les sels mentionnés ci-avant, on préfère encore plus particulièrement utiliser, selon la présente invention, le chlorure de manganèse (MnCl2). Selon la présente invention, les sels hydrosolubles de manganèse divalent, en comparaison du Triclosan bien connu dans le domaine considéré, présentent l'avantage d'être plus efficaces sur la réduction de l'intensité et du désagrément de l'odeur et d'être inodores aux concentrations d'utilisation.For the purposes of the present invention, the term water-soluble manganese salts is understood to mean manganese salts of organic or mineral acids whose solubility in water, expressed as a percentage by weight of Mn ion, is greater than or equal to 0.3. Particularly preferred water-soluble manganese salts according to the present invention are manganese chloride, manganese acetate, manganese sulfate. Among the salts mentioned above, it is still more particularly preferred to use, according to the present invention, manganese chloride (MnCl2). According to the present invention, the water-soluble salts of divalent manganese, in comparison with Triclosan well known in the field under consideration, have the advantage of being more effective in reducing the intensity and the unpleasantness of the odor and being odorless at use concentrations.
Les sels de manganèse divalent selon l'invention représentent de préférence de 0.01 à 20 % en poids environ du poids total de la composition cosmétique, plus particulièrement de 0.1 à 10 %, et plus préférentiellement encore de 0.1 à 5 % en poids environ de ce poids.The divalent manganese salts according to the invention preferably represent from 0.01 to 20% by weight approximately of the total weight of the cosmetic composition, more particularly from 0.1 to 10%, and even more preferably from 0.1 to 5% by weight approximately. weight.
Les actifs déodorants peuvent être choisis par exemple parmi : des sels hydrosolubles de zinc, comme par exemple le pyrrolidone carboxylate de zinc (plus communément appelé pidolate de zinc), le sulfate de zinc, le chlorure de zinc, le lactate de zinc, le gluconate de zinc et le phénoisuifonate de zinc ; d'autres composés non hydrosolubles de zinc comme par exemple le ricinoléate de zinc ; des bactéricides tels que le 2,4,4'-trichloro-2'-hydroxydiphényléther (Triclosan), ou le 3,7,11-triméthyldodéca-2,5,10-thénol (Farnesol). Ces actifs déodorants peuvent être présents dans la composition selon l'invention à raison d'environ 0,001 à 20% en poids par rapport à la composition totale, et de préférence à raison d'environ 0,1 à 5 % en poids. La composition cosmétique selon l'invention est formulée classiquement selon la forme de présentation à laquelle elle est destinée.The deodorant active agents can be chosen for example from: water-soluble zinc salts, such as for example zinc pyrrolidone carboxylate (more commonly called zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, gluconate zinc and zinc phenoisuifonate; other non-water-soluble zinc compounds such as, for example, zinc ricinoleate; bactericides such as 2,4,4'-trichloro-2'-hydroxydiphenylether (Triclosan), or 3,7,11-trimethyldodeca-2,5,10-thenol (Farnesol). These deodorant active agents can be present in the composition according to the invention in an amount of about 0.001 to 20% by weight relative to the total composition, and preferably in an amount of about 0.1 to 5% by weight. The cosmetic composition according to the invention is conventionally formulated according to the form of presentation for which it is intended.
Elle est plus particulièrement formulée dans un véhicule cosmétiquement acceptable qui peut être notamment essentiellement aqueux, ou contenir des solvants organiques et notamment des monoalcools en C C , de préférence de l'éthanol pour accélérer l'évaporation du produit, ou du propylène glycol, du dipropylène glycol ou leurs éthers.It is more particularly formulated in a cosmetically acceptable vehicle which can in particular be essentially aqueous, or contain organic solvents and in particular CC monoalcohols, preferably ethanol to accelerate the evaporation of the product, or propylene glycol, dipropylene glycol or their ethers.
La composition cosmétique selon l'invention peut également être formulée en émulsion eau-dans-huile, huile-dans-eau, ou en émulsion triple eau-dans-huile- dans-eau, (de telles émulsions sont connues et décrites par exemple par C. FOX dans « Cosmetics and Toiletries » - november 1986 - Vol 101 - pages 101-112).The cosmetic composition according to the invention can also be formulated as a water-in-oil emulsion, oil-in-water, or as a triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C. FOX in "Cosmetics and Toiletries" - November 1986 - Vol 101 - pages 101-112).
La composition cosmétique de l'invention peut comprendre en outre des adjuvants cosmétiques choisis parmi les corps gras, les gélifiants, les émollients, les adoucissants, les antioxydants, les opacifiants, les stabilisants, les agents anti-mousse, les agents hydratants, les vitamines, les parfums, les conservateurs, les tensioactifs, les charges, les séquestrants, les polymères, les propulseurs, les agents alcalinisants ou acidifiants, les parfums, les colorants, les pigments, les agents épaississants, ou tout autre ingrédient habituellement utilisé en cosmétique pour ce type d'application.The cosmetic composition of the invention may also comprise cosmetic adjuvants chosen from fatty substances, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, anti-foaming agents, moisturizing agents, vitamins , perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics for this type of application.
Bien entendu, l'homme de métier veillera à choisir ce ou ces éventuels composés complémentaires de manière telle que les propriétés avantageuses attachées intrinsèquement à la composition cosmétique conforme à l'invention ne soient pas, ou sustantiellement pas, altérées par la ou les adjonctions envisagées.Of course, the person skilled in the art will take care to choose this or these optional additional compounds in such a way that the advantageous properties intrinsically attached to the cosmetic composition in accordance with the invention are not, or substantially not, impaired by the addition (s) envisaged. .
Les tensio-actifs sont choisis de préférence parmi les tensio-actifs anioniques, amphotères ou non-ioniques.The surfactants are preferably chosen from anionic, amphoteric or nonionic surfactants.
Les corps gras peuvent être constitués par une huile ou une cire ou leur mélange, la vaseline, la paraffine, la lanoline, la lanoline hydrogénée, la lanoline acétylée ; ils comprennent également les acides gras, les alcools gras tels que l'alcool laurique, cétylique, myristique, stéarique, palmitique, oléique ainsi que le 2- octyldodécanol, les esters d'acides gras tels que le monostéarate de glycérol, le monostéarate de polyéthylèneglycol, le myristate d'isopropyle, l'adipate d'isopropyle, le palmitate d'isopropyle, le palmitate d'octyle, les benzoates d'alcools gras en C-12-C15 (Finsolv TN de FINETEX), l'alcool myristique polyoxypropyléné à 3 moles d'oxyde de propylène (WITCONOL APM de WITCO), les triglycérides d'acides gras en CQ-C- Q tels que les triglycérides d'acide caprylique/caprique. Les huiles sont choisies parmi les huiles animales, végétales, minérales ou de synthèse et notamment l'huile de palme hydrogénée, l'huile de ricin hydrogénée, l'huile de vaseline, l'huile de paraffine, l'huile de Purcellin (octanoate de stéaryle), les huiles de silicone et les isoparaffines.The fatty substances can consist of an oil or a wax or a mixture thereof, petrolatum, paraffin, lanolin, hydrogenated lanolin, acetylated lanolin; they also include fatty acids, fatty alcohols such as lauric, cetyl, myristic, stearic, palmitic, oleic alcohol as well as 2-octyldodecanol, fatty acid esters such as glycerol monostearate, polyethylene glycol monostearate , isopropyl myristate, isopropyl adipate, isopropyl palmitate, octyl palmitate, benzoates fatty alcohols in C-12-C15 (Finsolv TN from FINETEX), myristic polyoxypropylenated alcohol with 3 moles of propylene oxide (WITCONOL APM from WITCO), triglycerides of fatty acids in CQ-C- Q such than caprylic / capric acid triglycerides. The oils are chosen from animal, vegetable, mineral or synthetic oils and in particular hydrogenated palm oil, hydrogenated castor oil, vaseline oil, paraffin oil, Purcellin oil (octanoate stearyl), silicone oils and isoparaffins.
Les cires sont choisies parmi les cires animales, fossiles, végétales, minérales ou de synthèse. On peut citer notamment les cires d'abeille, les cires de Carnauba, de Candelila, de canne à sucre, du Japon, les ozokérites, la cire de Montan, les cires microcristallines, les paraffines, les cires et résines de silicone.The waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. Mention may in particular bees beeswaxes, Carnauba, Candelila, sugar cane, Japanese waxes, ozokerites, Montan wax, microcrystalline waxes, paraffins, waxes and silicone resins.
Les épaississants, de préférence non ioniques, peuvent être choisis parmi les gommes de guar et celluloses modifiées ou non modifiées telles que la gomme de guar hydroxypropylée, la cétylhydroxyéthylcellulose, les silices comme par exemple la Bentone Gel MiO vendue par la société NL INDUSTRIES ou laThe thickeners, preferably nonionic, can be chosen from guar gums and modified or unmodified celluloses such as hydroxypropylated guar gum, cetylhydroxyethylcellulose, silicas such as, for example, Bentone Gel MiO sold by the company NL INDUSTRIES or
Veegum Ultra, vendue par la société POLYPLASTIC.Veegum Ultra, sold by the company POLYPLASTIC.
La composition cosmétique peut comprendre des émollients, qui contribuent à une sensation douce, sèche, non-collante à l'application de la composition sur la peau. Ces émollients peuvent être choisis parmi des produits du type silicone volatile, des silicones non-volatiles et d'autres émollients non-volatils. Les silicones volatiles sont définies de façon connue comme des composés volatils à température ambiante. On peut citer parmi ces composés les silicones volatiles cycliques et linéaires du type diméthylsiloxane dont les chaînes comprennent de 3 à 9 résidus silicones. De préférence on choisit les cyclométhicones D4 ou D5.The cosmetic composition can comprise emollients, which contribute to a soft, dry feeling, non-sticky when the composition is applied to the skin. These emollients can be chosen from products of the volatile silicone type, non-volatile silicones and other non-volatile emollients. Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type, the chains of which comprise from 3 to 9 silicone residues. Preferably, cyclomethicones D4 or D5 are chosen.
Les silicones non-volatiles sont définies de façon connue comme des composés de pression de vapeur faible à température ambiante. Parmi ces composés sont inclus : les polyalkylsiloxanes, en particulier les polyalkylsiloxanes linéaires comme par exemple les polydiméthylsiloxanes, ou diméthicones, linéaires, commercialisés par la société Dow Corning sous le nom de « Dow Corning 200 Fluid » ; les polyalkylarylsiloxanes comme par exemple les polyméthylphénylsiloxanes, commercialisés par la société Dow Corning sous le nom de « Dow Corning 556 Fluid » ; les copolymères polyéther et siloxane, comme par exemple les diméthicone copolyols.Non-volatile silicones are defined in a known manner as compounds with low vapor pressure at room temperature. Among these compounds are included: polyalkylsiloxanes, in particular linear polyalkylsiloxanes such as, for example, linear polydimethylsiloxanes, or dimethicones, sold by the company Dow Corning under the name of "Dow Corning 200 Fluid"; polyalkylarylsiloxanes such as for example polymethylphenylsiloxanes, sold by the company Dow Corning under the name of "Dow Corning 556 Fluid"; polyether and siloxane copolymers, such as, for example, dimethicone copolyols.
Parmi les émollients non-volatils utilisables dans la présente invention, on peut citer par exemple : les dérivés hydrocarbonés, les huiles minérales, les alcools gras, les esters d'alcools en C3-Cι8 avec des acides en C3-C-ιs, les esters de l'acide benzoïque avec des alcools en Cι2-Cιs et leurs mélanges, des polyols en C2-C6 choisis de préférence parmi le glycérol, le propylèneglycol ou le sorbitol, les polymères de polalkylène glycol. Les quantités de ces différents constituants pouvant être présents dans la composition cosmétique selon l'invention sont celles classiquement utilisées pour les formes de présentation considérées.Among the nonvolatile emollients useful in the present invention include for example: hydrocarbon-based derivatives, mineral oils, fatty alcohols, alcohol esters of C 3 -Cι 8 with C 3 -C acids ιs, benzoic acid esters with Cι 2 -Cι alcohols and their mixtures, C 2 -C 6 polyols preferably chosen from glycerol, propylene glycol or sorbitol, polymers of polalkylene glycol. The amounts of these various constituents which may be present in the cosmetic composition according to the invention are those conventionally used for the forms of presentation considered.
La composition selon l'invention peut ainsi se présenter sous forme de lotion, de crème ou de gel fluide distribué en spray aérosol, en flacon pompe ou en roll-on, sous forme de crème épaisse distribuée en tube et sous forme de stick ou de poudre, et contenir à cet égard les ingrédients et propulseurs généralement utilisés dans ce type de produits et bien connus de l'homme de l'art.The composition according to the invention can thus be in the form of a lotion, cream or fluid gel distributed in aerosol spray, in pump bottle or in roll-on, in the form of thick cream distributed in tube and in the form of stick or powder, and contain in this regard the ingredients and propellants generally used in this type of product and well known to those skilled in the art.
Elle peut également constituer des supports fibreux naturels, synthétiques ou artificiels, tissés ou non tissés, destinés à l'application topique (plus communément appelés "lingettes").It can also constitute natural, synthetic or artificial, woven or nonwoven fibrous supports, intended for topical application (more commonly called "wipes").
Des exemples concrets, mais nullement limitatifs, illustrant l'invention vont maintenant être donnés. Concrete, but in no way limiting, examples illustrating the invention will now be given.
EXEMPLE 1 : Test in vitro d'évaluation d'odeursEXAMPLE 1 In Vitro Odor Test
Comparaison de l'efficacité du chlorure de manganèse [(MnCl2)(invention)] contre celle de l'actif déodorant de l'art antérieur (Triclosan).Comparison of the effectiveness of manganese chloride [(MnCl2) (invention)] against that of the deodorant active agent of the prior art (Triclosan).
On a réalisé un test d'inhibition de l'évolution d'odeurs sur de la sueur naturelle. Le principe de ce test consiste en l'ajout de l'agent déodorant à la sueur fraîche, puis à procéder à une évaluation olfactive par un jury d'experts après 18 heures puis 24 heures d'incubation à 37°C.A test of inhibition of the evolution of odors was carried out on natural sweat. The principle of this test consists in adding the deodorant agent to the fresh sweat, then in carrying out an olfactory evaluation by a jury of experts after 18 hours then 24 hours of incubation at 37 ° C.
On a donc prélevé en sauna les sueurs axillaires de plusieurs modèles humains que l'on a réunies pour réaliser un échantillon de sueur. Pour obtenir l'odeur nauséabonde caractéristique de la sueur, avant d'introduire la substance active, on a incubé cet échantillon de sueur pendant 18 heures puis 24 heures à la température de 37°C. Dans chaque flacon de substance active à tester ainsi que dans un flacon témoin (sans substance active), on a introduit 1 ml de l'échantillon de sueur incubée. Puis on a introduit la substance active dans chacun des flacons à tester.We therefore took axillary sweats from several human models in a sauna, which we gathered to make a sweat sample. To obtain the characteristic foul odor of sweat, before introducing the active substance, this sweat sample was incubated for 18 hours then 24 hours at a temperature of 37 ° C. In each bottle of active substance to be tested as well as in a control bottle (without active substance), 1 ml of the incubated sweat sample was introduced. Then the active substance was introduced into each of the vials to be tested.
Résultats :Results:
Les résultats ont été donnés en pourcentages de variation (réduction) de l'odeur et de la note hédonique par rapport à la sueur témoin sans agent déodorant. Pour 1 mg de matière active par ml de sueur, soit 0,1% :The results were given in percentages of variation (reduction) of the odor and the hedonic note compared to the control sweat without deodorant agent. For 1 mg of active ingredient per ml of sweat, i.e. 0.1%:
Les résultats démontrent que le chlorure de manganèse présente une réduction aussi importante que le Triclosan voire plus, sur l'intensité et le désagrément de l'odeur de la sueur naturelle pendant au moins 18h. EXEMPLE 2 : Détermination de l'activité biocide La détermination de l'activité microbiostatique du MnCl2 a été effectuée comparativement au Triclosan (actif déodorant de l'art antérieur), par la méthode des dilutions en milieu gélose.The results demonstrate that manganese chloride has a reduction as great as Triclosan or more, on the intensity and the unpleasant odor of natural sweat for at least 18 hours. EXAMPLE 2 Determination of the Biocidal Activity The determination of the microbiostatic activity of MnCl2 was carried out compared to Triclosan (deodorant active agent of the prior art), by the method of dilutions in agar medium.
Chacun des 2 composés a été présenté sous forme de solution éthanolique, le MnCl2 à 10% de matière Active (MA) et le Triclosan à 1% MA.Each of the 2 compounds was presented in the form of an ethanolic solution, MnCl2 at 10% Active material (MA) and Triclosan at 1% MA.
Cent μl de la solution éthanolique ont été ajoutés à 0,9 ml de culture gélose en surfusion à 45°C (milieu choisi en fonction des exigences nutritives de la souche étudiée). Après agitation Vortex, des dilutions successives, en progression géométrique de raison 2, de la solution obtenue ont été réalisées à l'aide du milieu de culture gélose en surfusion à 45°C. Un ml de chaque dilution a été introduit dans les puits d'une microplaque (Flacon, 24 puits). Quatre μl de suspension microbienne ont été déposés à la surface du milieu gélose.One hundred μl of the ethanolic solution was added to 0.9 ml of agar culture by supercooling at 45 ° C. (medium chosen according to the nutritional requirements of the strain studied). After Vortex stirring, successive dilutions, in geometric progression of reason 2, of the solution obtained were carried out using the agar culture medium in supercooling at 45 ° C. One ml of each dilution was introduced into the wells of a microplate (bottle, 24 wells). Four μl of microbial suspension were deposited on the surface of the agar medium.
Deux puits témoin ont également été préparés : H2O 100 μl + 0,9 ml de milieu de culture (témoin de croissance), éthanol 100 μl + 0,9 ml de milieu de cultureTwo control wells were also prepared: H 2 O 100 μl + 0.9 ml of culture medium (growth control), ethanol 100 μl + 0.9 ml of culture medium
Après incubation dans des conditions (température, atmosphère et durée) fonction de la souche étudiée, la Concentration Minimale Inhibitrice (CMI) est donnée par la plus faible concentration de produit qui inhibe la croissance microbienne.After incubation under conditions (temperature, atmosphere and duration) depending on the strain studied, the Minimum Inhibitory Concentration (MIC) is given by the lowest concentration of product which inhibits microbial growth.
Résultats : exprimés en % p/v. Pour les cupules témoin (H2O ou éthanol), l'observation d'une croissance microbienne a permis d'exclure la présence d'un effet placebo.Results: expressed in% w / v. For the control wells (H 2 O or ethanol), the observation of microbial growth made it possible to exclude the presence of a placebo effect.
Les résultats démontrent que l'activité biocide du MnCl2 est très nettement inférieure à celle du Triclosan sur les 2 souches bactériennes testées de la flore cutanée résidente et que l'efficacité du MnCl2 n'apparaît pas directement reliée à un effet biocide puisqu'elle est constatée à des concentrations 2 fois inférieures à la CMI. The results demonstrate that the biocidal activity of MnCl2 is very much lower than that of Triclosan on the 2 bacterial strains tested from the resident skin flora and that the effectiveness of MnCl2 does not appear to be directly linked to a biocidal effect since it is found at concentrations 2 times lower than the MIC.
EXEMPLE 3 : Spray (flacon-pompe)EXAMPLE 3: Spray (pump bottle)
MnCI2, 4H20 3.00 gMnCI 2 , 4H20 3.00 g
Parfum, colorants qsPerfume, dyes qs
Alcool éthylique 95 % vol. dénaturé 100 gEthyl alcohol 95% vol. denatured 100 g
EXEMPLE 4 : Emulsion eau-dans-siliconeEXAMPLE 4 Water-in-silicone emulsion
Silicone DC 245 Fluid (DOW CORNING) 6,60 gDC 245 Fluid silicone (DOW CORNING) 6.60 g
Silicone DC 5225 C (DOW CORNING) 9,40 gSilicone DC 5225 C (DOW CORNING) 9.40 g
Alcool éthylique 11 ,00 gEthyl alcohol 11.00 g
Propylène glycol 37,00 gPropylene glycol 37.00 g
MnCI2, 4H20 3,00 gMnCI 2 , 4H 2 0 3.00 g
Parfum, conservateurs, colorants qsPerfume, preservatives, dyes qs
Eau déminéralisée qsp 100 gDemineralized water qs 100 g
EXEMPLE 5 : Roll-on hvdroalcoolique transparentEXAMPLE 5: Transparent hydroalcoholic roll-on
Alcool cétylique oxyéthyléné (20 OE) et oxypropylénéOxyethylenated (20 EO) and oxypropylenated cetyl alcohol
(5 OP) 2,00 g(5 OP) 2.00 g
Hydroxyéthylcellulose 0,75 gHydroxyethylcellulose 0.75 g
MnCI2> 4H20 2,50 gMnCI 2> 4H 2 0 2.50 g
Alcool éthylique 95 % vol. dénaturé 45,00 gEthyl alcohol 95% vol. denatured 45.00 g
Parfum qsPerfume qs
Eau déminéralisée qsp 100 g EXEMPLE 6 : Crème pour les piedsDemineralized water qs 100 g EXAMPLE 6 Foot Cream
Mélange mono/distéarate de glyceryle / stéarate de 8,00 g polyethylène glycol (100 OE)8.00 g polyethylene glycol (100 EO) mono / glyceryl distearate / stearate mixture
Alcool cétylique 2.50 gCetyl alcohol 2.50 g
Mélange cire microcristalline / cire d'abeille / 1.00 g polyethylèneMicrocrystalline wax / beeswax / 1.00 g polyethylene blend
Cire liquide de jojoba 6.00 gLiquid jojoba wax 6.00 g
Myristate de myristyle oxyéthyléné (3 OE) 2.00 gOxyethylenated myristyl myristate (3 EO) 2.00 g
MnCl2, 4H20 5,00 gMnCl2, 4H 2 0 5.00 g
Parfum, conservateurs qsPerfume, preservatives qs
Eau déminéralisée qsp 100 gDemineralized water qs 100 g
EXEMPLE 7 : Lotion pour le cuir cheveluEXAMPLE 7 Lotion for the scalp
Alcool éthylique 95% vol. dénaturé 55.00 gEthyl alcohol 95% vol. denatured 55.00 g
MnCl2, 4H20 3,00 gMnCl2, 4H 2 0 3.00 g
Propylène glycol 10.00 gPropylene glycol 10.00 g
Parfum, colorant qsPerfume, coloring qs
Eau déminéralisée qsp 100 g Demineralized water qs 100 g

Claims

REVENDICATIONS
1. Utilisation d'au moins un sel de manganèse divalent, comme agent réducteur de l'intensité de l'odeur de sueur humaine décomposée par les bactéries, dans une composition cosmétique.1. Use of at least one divalent manganese salt, as an agent for reducing the intensity of the odor of human sweat broken down by bacteria, in a cosmetic composition.
2. Utilisation selon la revendication 1 , caractérisée par le fait que le sel de manganèse est un sel hydrosoluble.2. Use according to claim 1, characterized in that the manganese salt is a water-soluble salt.
3. Utilisation selon les revendications 1 ou 2, caractérisée par le fait que le sel est le chlorure de manganèse (MnCl2).3. Use according to claims 1 or 2, characterized in that the salt is manganese chloride (MnCl2).
4. Utilisation selon l'une quelconque des revendications précédentes, caractérisée par le fait que le ou les sels de manganèse divalent, représentent de 0.01 % à4. Use according to any one of the preceding claims, characterized in that the divalent manganese salt or salts represent from 0.01% to
20% de Matière Active en poids par rapport au poids total de la composition.20% of Active Material by weight relative to the total weight of the composition.
5. Utilisation selon la revendication 4, caractérisée par le fait que le ou les sels de manganèse divalent, représentent de 0.1 à 10 % de Matière Active en poids par rapport au poids total de la composition.5. Use according to claim 4, characterized in that the divalent manganese salt or salts represent from 0.1 to 10% of active material by weight relative to the total weight of the composition.
6. Utilisation selon la revendication 5, caractérisée par le fait que le ou les sels de manganèse divalent, représentent de 0.1 à 5 % de Matière Active en poids par rapport au poids total de la composition.6. Use according to claim 5, characterized in that the divalent manganese salt or salts represent from 0.1 to 5% of active material by weight relative to the total weight of the composition.
7. Composition cosmétique destinée à être appliquée sur la peau humaine, comprenant dans un véhicule cosmetiquement acceptable, au moins un actif antitranspirant ou déodorant, caractérisée par le fait qu'elle comprend en outre au moins un sel de manganèse divalent à titre d'agent réducteur de l'intensité de l'odeur de sueur humaine décomposée par les bactéries.7. Cosmetic composition intended to be applied to human skin, comprising in a cosmetically acceptable vehicle, at least one antiperspirant or deodorant active agent, characterized in that it also comprises at least one divalent manganese salt as agent reducing the intensity of the smell of human sweat broken down by bacteria.
8. Composition selon la revendication 7, caractérisée par le fait que le véhicule est essentiellement aqueux. 8. Composition according to claim 7, characterized in that the vehicle is essentially aqueous.
9. Composition selon la revendication 8, caractérisée par le fait que le véhicule contient en outre des solvants organiques.9. Composition according to claim 8, characterized in that the vehicle also contains organic solvents.
10. Composition selon l'une quelconque des revendications 7 à 9, caractérisée par le fait qu'elle contient en outre des adjuvants cosmétiques choisis parmi les corps gras, les gélifiants, les émollients, les adoucissants, les antioxydants, les opacifiants, les stabilisants, les agents anti-mousse, les agents hydratants, les vitamines, les parfums, les conservateurs, les tensioactifs, les charges, les séquestrants, les polymères, les propulseurs, les agents alcalinisants ou acidifiants, les parfums, les colorants, les pigments, les agents épaississants, ou tout autre ingrédient habituellement utilisé en cosmétique.10. Composition according to any one of claims 7 to 9, characterized in that it also contains cosmetic adjuvants chosen from fatty substances, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers , anti-foaming agents, moisturizers, vitamins, perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, alkalizing or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics.
11. Composition selon l'une quelconque des revendications 7 à 10, caractérisée par le fait qu'elle est formulée en émulsion eau-dans-huile, huile-dans-eau, ou en émulsion triple eau-dans-huile-dans-eau.11. Composition according to any one of claims 7 to 10, characterized in that it is formulated in water-in-oil emulsion, oil-in-water, or in water-in-oil-in-water triple emulsion .
12. Composition selon l'une quelconque des revendications 7 à 11 , caractérisée par le fait qu'elle se présente sous la forme de lotion, de crème ou de gel fluide distribué en spray aérosol, en flacon pompe ou en roll-on, sous forme de crème épaisse distribuée en tube et sous forme de stick ou de poudre, ou de supports fibreux naturels, synthétiques, artificiels, tissés ou non tissés.12. Composition according to any one of claims 7 to 11, characterized in that it is in the form of a lotion, cream or fluid gel distributed in aerosol spray, in pump bottle or in roll-on, under form of thick cream distributed in a tube and in the form of a stick or powder, or natural, synthetic, artificial, woven or nonwoven fibrous supports.
13. Utilisation d'une composition selon l'une quelconque des revendications 7 à 12, comme, ou pour la fabrication de, produits cosmétiques antitranspirants ou déodorants destinés à l'application topique humaine.13. Use of a composition according to any one of claims 7 to 12, as, or for the manufacture of, antiperspirant or deodorant cosmetic products intended for topical human application.
14. Procédé pour réduire les odeurs corporelles humaines résultant de leur décomposition par les bactéries, consistant à appliquer sur la surface axillaire, le cuir chevelu, ou les pieds, une quantité efficace d'un sel de manganèse divalent.14. A method for reducing human body odors resulting from their decomposition by bacteria, consisting in applying to the axillary surface, the scalp, or the feet, an effective amount of a divalent manganese salt.
15. Procédé selon la revendication 14, caractérisé par le fait qu'il s'agit du chlorure de manganèse (MnCl2). 15. The method of claim 14, characterized in that it is manganese chloride (MnCl2).
EP01923796A 2000-04-18 2001-04-11 Divalent manganese salts for reducing odour resulting from bacterial decomposition of human perspiration Withdrawn EP1276454A2 (en)

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FR0004995A FR2807655B1 (en) 2000-04-18 2000-04-18 USE OF DIVALENT MANGANESE SALTS AS DEODORANT ASSETS IN COSMETIC COMPOSITIONS
PCT/FR2001/001111 WO2001078658A2 (en) 2000-04-18 2001-04-11 Divalent manganese salts for reducing odour resulting from bacterial decomposition of human perspiration

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FR2807655A1 (en) 2001-10-19
AU2001250484A1 (en) 2001-10-30
WO2001078658A2 (en) 2001-10-25
FR2807655B1 (en) 2005-05-20
WO2001078658A3 (en) 2002-04-04

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