FR2789900A1 - Antimicrobial agent for treatment of hyperseborrhea, acne, and scalp disorders, as well as for bucco-dental hygiene comprises Asterostigma sp. extract - Google Patents

Abstract

An antimicrobial agent comprising an extract of cells from an Asterostigma sp. plant of the Myrtaceae family for use in cosmetic and dermatological compositions, is new. A new antimicrobial agent comprises an extract of cells from an Asterostigma sp. plant of the Myrtaceae family. The extracts may be taken from any part of the plant, but preferably from the stem, bark, or leaves. Compositions preferably contain 0.05 - 20 % of active material, 0.1 - 5 % being especially preferred.

Description

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An antimicrobial agent based on Asterostigma Sp extract and its use in a dermatological or cosmetic composition.

 The present invention relates to the use of an Asterostigma Sp extract as an antimicrobial agent, a cosmetic or dermatological composition comprising this antimicrobial agent, the use of this antimicrobial agent as a deodorant active agent, a preservative, an active agent for the treatment of hyperseborrhoea and / or acne or scalp conditions.

 It is common to introduce into the cosmetic or dermatological compositions antimicrobial agents. Indeed, these antimicrobial agents are especially intended to prevent the development and proliferation of microorganisms in these compositions. Such development of microorganisms would rapidly render these compositions unfit for use. To avoid this development, it is necessary to protect the compositions both against the microorganisms that can develop inside the compositions and against those that the user can introduce into them by manipulating them, in particular when gripping the products with the fingers.

 These antimicrobial agents are also used to inhibit or regulate the development of cutaneous bacterial flora, this cutaneous flora including degrading sweat and thus causing the formation of malodorous volatile products.

 Cutaneous bacterial flora is implicated, as is well known, in inflammatory skin conditions such as acne, scalp conditions or seborrheic dermatitis.

 The bactericidal substances used to reduce or even eliminate the generally unpleasant axillary odors, inhibit the

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 development of cutaneous bacterial flora responsible for these axillary odors. Of the bactericidal products, the most commonly used is Triclosan (5-chloro-2- (2,4-dichlorophenoxy) phenol), which has the disadvantage of significantly modifying the ecology of cutaneous bacterial flora. be inhibited by certain compounds, such as nonionic surfactants, commonly used in the formulation of cosmetic compositions. The insoluble nature of Triclosan in water does not allow its incorporation into essentially aqueous formulas.

 In order to achieve long-term effectiveness, new products with a deodorant active action, that is, products capable of modifying, reducing and / or removing or prevent the development of body odor (this definition is given in "Cosmetic Science and Technology Series" - 1988 / Volume 7, Chapter 10 - IIIc). In addition, we seek products that do not have the disadvantages of the active substances used in the prior art.

 The most commonly used chemical preservatives as the antimicrobial agent include C1-C4 alkyl parahydroxybenzoates, or formalin donors.

Unfortunately, these preservatives have the disadvantage of being either ineffective or causing intolerances on human skin, such as irritations and / or allergies, and more particularly on sensitive skin. It is the same for alcohols or polyols, such as ethanol or propylene glycol, especially when they are present at relatively high levels.

 Furthermore, it is known to use preservatives in skin-cleaning products such as benzalkonium chloride, chloroacetamide or thimerosal. Thus, WO-A-94/27436 teaches a preservative system comprising a paraben and a quaternary ammonium compound such as benzalkonium chloride or cetylpyridinium chloride. However, the current trend and related legislation are increasingly moving towards the removal of these compounds because they are not completely devoid of toxicity or adverse effects.

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 It is therefore found that there remains the need for preservatives having an action at least as effective as those of the preservatives of the prior art but not presenting their disadvantages by being in particular non-irritating to the skin or the scalp.

 Similarly, active agents used to treat hyperseborrhoea and / or acne or scalp conditions used up to now can cause undesirable effects, including irritation of the skin or the skin. scalp.

Thus, one seeks assets for the treatment of hyperseborrhoea and / or acne or scalp conditions, effective and not having these disadvantages.

 After much research on the subject, the Applicant has surprisingly discovered that Asterostigma Sp extracts can be used as an antimicrobial agent.

In particular, it has been found that this antimicrobial agent exhibits bacteriostatic activity, and thus makes it possible to regulate the bacterial flora without modifying it qualitatively. These extracts thus have the particular property of preventing the development of bad odors, without the disadvantages of the active substances previously used in the deodorant compositions.

 It has also been observed that these extracts of Asterostigma Sp can be used as a natural preservative and as active agents for the prevention or treatment of hyperseborrhoea and / or acne or scalp conditions. Indeed, it has been found that the compositions in accordance with the invention make it possible not only to obtain a rapid improvement of the inflammatory acne state, but also to lead to the reduction of so-called first-type lesions with a non-inflammatory characteristic, just as to get an improvement of the scalp conditions.

 Extracts of Asterostigma Sp can still be used in oral-dental compositions; these extracts may especially be used as preservatives both in anhydrous oral compositions and in aqueous oral compositions.

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The antibacterial agents of the invention also have the advantage of being water-soluble in desirable proportions and sufficient to be easily formulated, especially in water-based cosmetic compositions for topical application.
5 human.

 These compositions are further non-toxic and non-irritating.

 Subsequently, the term "Asterostigma Sp extract", formerly known as "Calycorectes", should be understood as "Asterostigma Sp cell extract" and more specifically as "extract from cells of at least one plant of the plant. genus Asterostigma Sp of the family Myrtaceae ". Said material can be obtained by in vitro culture or in vivo.

 By in vitro culture is meant all of the techniques known to those skilled in the art which artificially allow the production of a plant or part of a plant.

 In vivo culture means all the cultivation techniques for obtaining a plant or part of a plant.

 Thus, for example, according to the invention, the extract may be an organ extract (root, stem, leaf, bark), or even organ cells, of at least one plant of the genus Asterostigma Sp from the Myrtaceae family, or an undifferentiated cell extract from at least one such plant.

 By undifferentiated plant cells is meant any plant cell having none of the characters of a particular specialization and capable of living on its own and not dependent on other cells. These undifferentiated plant cells are capable, under the effect of an induction, to any differentiation according to their genome.

Depending on the culture method chosen, and in particular on the chosen culture medium, it is possible to obtain from the same explant undifferentiated plant cells having different characters.

 The extracts of the invention are in particular purified extracts.

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 Any method of purification or extraction known to those skilled in the art can be used according to the invention.

 Mention may in particular be made of alcoholic extracts, in particular ethanolic extracts and hydroalcoholic extracts.

 It is also possible to use an extract prepared by the method described in French Patent Application No. 95 02379.

 Thus, in a first step, the plant material is crushed in a cold aqueous solution, in a second step the suspended particles are removed from the aqueous solution resulting from the first step, and in a third step the aqueous solution resulting from the first step is sterilized. the second step. This aqueous solution corresponds to the extract.

 On the other hand, the first step may advantageously be replaced by a simple freezing operation of the plant tissues (for example at -20 ° C.), followed by an aqueous extraction taking up the second and third steps described above.

 In a variant of this process, a hydroalcoholic solution is used in the first step and in the third step, the solution is evaporated to dryness, the residue being used as it is or after purification.

 It is also possible to use the sonification extraction method described by E. A. MAGEL and Co. 1991. Trees-Volume 5. - 203-207.

 The subject of the invention is therefore the use of an Asterostigma Sp extract of the Myrtaceae family as an antimicrobial agent in dermatological or cosmetic compositions.

 Another subject of the invention consists of a cosmetic or dermatological composition comprising such an extract.

 Another subject of the invention is the use of this extract as a deodorant active agent, antiperspirant active agent, odor-inhibiting agent, preservative agent, active agent for the cosmetic treatment of hyperseborrhoea and / or acne, or active agent for the cosmetic treatment of scalp conditions.

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 The invention also relates to the use of an extract according to the invention in a cosmetic or dermatological composition for limiting microbial proliferation.

 The invention also relates to the use of an extract according to the invention for the preparation of a dermatological or cosmetic composition for treating hyperseborrhoea and / or acne, or scalp conditions.

 The invention also relates to the use of an extract according to the invention for the preparation of a composition for oral hygiene.

 The invention also relates to cosmetic treatment methods using these compositions.

 The essential subject of the present invention is the use of an extract of cells from at least one plant of the genus Asterostigma Sp from the Myrtaceae family as an antimicrobial agent in cosmetic or dermatological compositions.

 The extract of Asterostigma Sp may especially be an extract of stem cells, bark or leaves of Asterostigma Sp.

 The present invention also relates to a cosmetic composition comprising at least one extract as defined above in a cosmetically acceptable medium.

 This cosmetic composition may comprise the extract in an amount representing from 0.05 to 20% by weight of the total weight of the composition and preferably in an amount representing from 0.1 to 5% by weight of the total weight of the composition. .

 The present invention also relates to a dermatological composition comprising at least one extract as defined above in a dermatologically acceptable medium.

 This dermatological composition may comprise an extract in an amount representing from 0.01 to 30% by weight of the total weight of the composition and preferably in an amount representing from 0.05 to 10% by weight of the total weight of the composition.

 The cosmetic or dermatological compositions of the invention may furthermore comprise, depending on the applications

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 for which they are intended, adjuvants chosen from fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, silicones, anti-foam agents, moisturizing agents, vitamins , perfumes, preservatives, surfactants, fillers, sequestering agents, polymers, propellants, alkalizing or acidifying agents, perfumes, dyes, pigments, thickeners, or any other adjuvant commonly used in cosmetic or dermatological.

 The surfactants are preferably chosen from anionic surfactants, in particular alkyl sulphates and alkyl ether sulphates, amphoteric in particular betaines and imidazoline or nonionic derivatives, and in particular those derived from sugar.

 The fatty substances may consist of an oil or a wax or a mixture thereof, petroleum jelly, paraffin, lanolin, hydrogenated lanolin or acetylated lanolin; they also include fatty acids, fatty alcohols such as lauryl, cetyl, myristic, stearic, palmitic, oleic alcohol as well as 2octyldodecanol, fatty acid esters such as glycerol monostearate, polyethylene glycol monostearate, isopropyl myristate, isopropyl adipate, isopropyl palmitate, octyl palmitate, C12-C15 fatty alcohol benzoates (Finesolv TN FINETEX), myristic alcohol polyoxypropylenated to 3 moles d propylene oxide (WITCONOL APM from WITCO), triglycerides of C6-C18 fatty acids such as caprylic / capric acid triglycerides.

 The oils are chosen from animal, vegetable, mineral or synthetic oils and in particular hydrogenated palm oil, hydrogenated castor oil, liquid petrolatum, paraffin oil, purcellin oil (octanoate stearyl), silicone oils and isoparaffins.

 The waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. These include beeswaxes, carnauba, candelilla, sugar cane, japan waxes, ozokerites, montan wax, microcrystalline waxes, paraffins, waxes and silicone resins.

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 The thickeners, preferably nonionic, may be selected from guar gums and modified or unmodified celluloses such as hydroxypropyl guar gum, cetylhydroxyethylcellulose, silicas such as Bentone Gel MiO sold by NL INDUSTRIES or Veegum Ultra, sold by the company POLYPLASTIC.

 The compositions of the invention may include emollients, which contribute to a soft, dry, non-sticky feel to the application of the composition to the skin. These emollients can be chosen from volatile silicone type products, non-volatile silicones and other non-volatile emollients. Generally emollients are present in proportions ranging from 20 to 80%, preferably from 25 to 60% and even more preferably from 35 to 55%.

 Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type whose chains comprise from 3 to 9 silicone residues. The cyclomethicones D4 or D5 are preferably chosen.

 Nonvolatile silicones are defined in a known manner as compounds with low vapor pressure at ambient temperature. Among these compounds are included: polyalkylsiloxanes, in particular linear polyalkylsiloxanes, for example linear polydimethylsiloxanes, or dimethicones, marketed by Dow Corning under the name Dow Corning 200 Fluid; polyalkylarylsiloxanes, for example polymethylphenylsiloxanes, sold by Dow Corning under the name Dow Corning 556 Fluid; polyether and siloxane copolymers, for example dimethicone copolyols.

 Among the non-volatile emollients that may be used in the present invention, there may be mentioned for example: hydrocarbon derivatives, mineral oils, fatty alcohols, esters of C3-C18 alcohols with C3-C18 acids, esters of benzoic acid with C12-C18 alcohols and mixtures thereof, C2-C6 polyols preferably selected from glycerol, propylene glycol or sorbitol, polalkylene glycol polymers.

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 According to the invention, the cosmetic and dermatological compositions may be combined with extracts of other active agents.

Among these active agents, there may be mentioned by way of example: agents which reduce differentiation and / or proliferation and / or cutaneous pigmentation such as retinoic acid and its isomers, retinol and its esters, vitamin D and its derivatives, estrogens such as estradiol, kojic acid or hydroquinone; antibacterials such as clindamycin phosphate, erythromycin or antibiotics of the tetracycline class; antiparasitics, in particular metronidazole, crotamiton or pyrethrinoids; antifungals, in particular with anti-dandruff action, in particular compounds belonging to the class of imidazoles such as econazole, ketoconazole or miconazole or their salts, polyene compounds, such as amphotericin B, compounds of the family of allylamines, such as terbinafine, or octopirox or zinc pyrithione; steroidal anti-inflammatory agents, such as hydrocortisone, betamethasone valerate or clobetasol propionate, or non-steroidal anti-inflammatory agents such as, for example, ibuprofen and its salts, diclofenac and its salts, acid acetylsalicylic acid, acetaminophen or glycyrrhizic acid; anesthetic agents such as lidocaine hydrochloride and its derivatives; antipruritic agents such as thenaldine, trimeprazine or cyproheptadine; keratolytic agents such as [alpha] - and sshydroxycarboxylic or beta-ketocarboxylic acids, their salts, amides or esters and more particularly hydroxy acids such as glycolic acid, lactic acid, salicylic acid, acid citric and generally fruit acids, and n-octanoyl-5salicylic acid; anti-free radical agents, such as α-tocopherol or its esters, superoxide dismutases, certain metal chelators or ascorbic acid and its esters;

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 antiseborrhoeic agents and 5-cc-reductase inhibitors; anti-acne drugs such as retinoic acid or benzoyl peroxide; - deodorant active ingredients and - antiperspirant active ingredients.

 To the above list, other compounds may also be added, namely for example diazoxide, spiroxazone, phospholipids such as lecithin, linoleic and linolenic acids and their esters, lactones and their corresponding salts, anthralin, carotenoids, eicosatetraenoic and eicosatrienoic acids or their esters and amides, vitamin D and its derivatives, extracts of plant or bacterial origin.

 The deodorant active agents may be chosen for example from: water-soluble zinc salts, for example zinc pyrrolidone carboxylate (more commonly known as zinc pidolate), zinc sulphate, zinc chloride, zinc lactate, gluconate zinc and zinc phenolsulfonate. The antiperspirant active agents may be aluminum salts, for example aluminum chloride and aluminum hydroxyhalides; zirconium salts, such as, for example, zirconium oxide salts, hydroxyzirconyl salts; complexes of metals such as aluminum or zirconium with an amino acid such as for example glycine as described in US Pat. No. 3,792,068.

 The dermatologically or cosmetically acceptable medium may especially consist of water or mixtures of water and solvents such as lower alcohols such as ethanol or isopropanol, ethylene glycol, propylene glycol, dipropylene glycol and their ethers.

 The compositions according to the invention may be ingested or applied to the skin (on any cutaneous zone of the body), the hair, the nails or the mucous membranes (buccal, jugal, gingival, genital, conjunctival). Depending on the mode of administration, the composition according to the invention may be in any of the galenical forms normally used.

 The compositions according to the invention can especially be

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 present in the form of aqueous, alcoholic or aqueous-alcoholic solutions, lotions, creams or fluid gels, thick creams, powders and be distributed in aerosol spray, pump bottle or roll-on, in a tube or in the form of a stick and contain in this regard the ingredients and propellants generally used in such products and well known to those skilled in the art, provided that they do not interfere with the antimicrobial agents described in the present invention.

 The compositions according to the invention can also be formulated in water-in-oil, oil-in-water or triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C FOX in "Cosmetics and Toiletries" November 1986, Vol 101, pages 101-112), in which case the antimicrobial agent is present in the aqueous phase of the emulsion.

 The compositions according to the invention can thus be used as deodorant cosmetic or dermatological compositions, but also as hair care compositions, and especially a shampoo, styling lotions, treatment lotions, styling creams or gels, dye compositions (especially dyeing compositions). oxidation) optionally in the form of coloring shampoos, as restructuring lotions for the hair, permanent compositions (in particular a composition for the first time of a perm), antiparasitic shampoos, etc.

 The composition according to the invention may also be for oral use, preferably a toothpaste. In this case, the composition may contain adjuvants and additives customary for oral compositions and in particular surfactants, thickeners, humectants, polishing agents such as silica, various active ingredients such as fluorides, in particular especially sodium fluoride, and optionally sweetening agents such as sodium saccharin.

 The amounts of the various constituents of the compositions according to the invention are those conventionally used in the fields under consideration.

 The compositions according to the invention may also

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 consist of solid preparations consisting of soaps or cleaning rolls.

 When the composition is an emulsion, the proportion of the fatty phase can range from 5% to 80% by weight and preferably from 5% to 50% by weight relative to the total weight of the composition. The oils, the waxes, the emulsifiers and the coemulsifiers used in the composition in emulsion form are chosen from those conventionally used in the cosmetics field. The emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition. The emulsion may further contain lipid vesicles.

 When the composition is a solution or an oily gel, the fatty phase may represent more than 90% of the total weight of the composition.

 The cosmetic or dermatological compositions of the present invention are formulated conventionally according to the applications for which they are intended.

 Another subject of the invention is the use of a composition according to the invention as a deodorant and / or antiperspirant composition.

 Another subject of the invention is also the use of an extract according to the invention for the preparation of a composition for oral hygiene, that is to say a composition intended in particular to restore and / or or to maintain the good condition of the oral cavity.

 Another subject of the invention also relates to the use of a composition as defined above as an oral-dental composition and preferably as a dentifrice composition.

 Another object of the invention is a cosmetic process for treating human axillary odors, comprising applying to the axillary surface an effective amount of a cosmetic composition according to the invention.

 Another method according to the invention relates to a cosmetic or dermatological treatment of the skin, superficial body growths or scalp, which consists in applying a composition to them.

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 cosmetic or dermatological as defined above, to leave it in contact, and possibly to rinse.

 The cosmetic treatment methods of the invention may be implemented in particular by applying the cosmetic compositions defined above, according to the usual techniques of use of these compositions. For example: application of creams, gels, lotions, milks on the skin.

 The following examples and compositions illustrate the invention without limiting it in any way.

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EXAMPLES Example 1: an extract of Asterostigma Sp:
Asterostigma Sp leaves of the Myrtaceae family, from Forit-Froin, Mangelia, New Caledonia, were used.

 A fractionation was then carried out consisting of drying and grinding the sheet into a powder.

 The powder was extracted with a water / ethanol mixture (40/60 by volume) at a rate of 10 parts per 1 part of plant at room temperature.

 After stirring for 5 hours, the mixture was filtered and / or centrifuged; the filtrate and / or the supernatant were evaporated to dryness.

 The residue was stored under phosphoric anhydride before use.

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Example 2 In Vitro Evaluation of Odor Evaluation
An odor absorption test was performed on natural sweat.

 The principle of this test is to add the antimicrobial agent to the fresh sweat, then to carry out an olfactory evaluation after 18 hours and 24 hours of incubation at 37 C.

 So we took in sauna axillary sweat of several human models that were put together to make a sweat sample. To obtain the foul odor characteristic of sweat, before introducing the active substance, this sweat sample was incubated for 18 hours at a temperature of 37 ° C. In each vial of active substance to be tested as well as in a control vial (without active substance), 1 ml of the sweat sample incubated was introduced and then the active substance was introduced into each of the test flasks.

1) After 18 hours of incubation, the odor of each flask was evaluated
Odor was assessed on 2 criteria: - overall intensity (score from 0 to 4)

<Tb>
<tb> 0 <SEP> 1 <SEP> 2 <SEP> 3 <SEP> 4 <SEP>
<tb> null <SEP> mild <SEP> moderate <SEP> strong <SEP> very <SEP> strong
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- hedonic appreciation (notation from 0 to 6).

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0 <SEP> 1 <SEP> 2 <SEP> 3 <SEP> 4 <SEP> 5 <SEP> 6
<tb> very <SEP> nice <SEP> nice <SEP> slightly <SEP> neutral <SEP> slightly <SEP> unpleasant <SEP> very
<tb> pleasant <SEP> unpleasant <SEP> unpleasant
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2) The flasks were incubated again in a 37 C oven for 6 h, the total desired incubation time being 24 h.

 The odor evaluation of each vial was then repeated as before.

3) RESULTS:
The results are given in percentages of variation of odor intensity and hedonic note compared to control sweat without antimicrobial agent:

<Tb>
<tb> Agent <SEP> Antimicrobial <SEP> Amount <SEP> MA <SEP>% <SEP> Variation <SEP>% <SEP> Vanation
<tb> mg / ml <SEP> of <SEP> sweat <SEP> intensity <SEP> of smell <SEP> annoyance <SEP> of <SEP> smell
<tb> Asterostigma <SEP> Sp <SEP> 2.5 <SEP> - <SEP> 39 <SEP>% <SEP> - <SEP> 26% <SEP>
<tb> 5 <SEP> - <SEP> 49 <SEP>% <SEP> - <SEP> 37% <SEP>
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The results demonstrate that the antimicrobial agents of the invention exhibit an important ability to inhibit the development of natural sweat odors for at least 24 hours.

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Example 3: microbiostatic activity
The microbiostatic activity of the extract obtained in Example 1 was determined by a conventional method called MIC (Minimum Inhibitory Concentration), the MIC corresponding to the lowest concentration at which a given product inhibits the growth of a plant. strain given under defined conditions.

 In this case, strains of Corynebacterium xerosis, reference CIP 5216 were used.

 The tests were carried out on dry extracts, namely the powder obtained in Example 1, at 5% in ethanol. 100 l of the solution were added to 1.9 ml of 45 C supercooled agar culture medium (medium chosen according to the nutritional requirements of the studied strain). After vortex stirring, successive dilutions, in geometric progression of reason 2, of the solution obtained were carried out using the agar culture medium in supercooling at 45 ° C. 1 ml of each dilution was introduced into the wells. a microplate (Falcon, 24 wells). 4 μl of microbial suspension were deposited on the surface of the agar medium.

 A control tube was also prepared: ethanol or H20 100 l + 1.9 ml of culture medium.

 The concentration of the antimicrobial agent from which the growth of the microorganism is completely inhibited (no disturbance of the medium) is thus determined.

 It has been observed that the shoot of Corynebacterium xerosis is blocked at the concentration of 5.5 × 10 -2 mg of dry extract per ml of culture medium.

Claims (25)

 1. Use of an extract of cells of at least one plant of the genus Asterostigma Sp of the Myrtaceae family as an antimicrobial agent in cosmetic or dermatological compositions.  2. Use according to claim 1, characterized in that the extract of Asterostigma Sp is an extract of stem cells, bark or leaves.  3. Cosmetic composition characterized in that it comprises at least one cell extract from at least one plant of the genus Asterostigma Sp of the family Myrtaceae in a cosmetically acceptable medium.  4. Cosmetic composition according to claim 3, characterized in that the Asterostigma Sp extract is an extract of stem cells, bark or leaves.  5. Cosmetic composition according to claim 3 or 4, characterized in that it comprises at least one cell extract of at least one plant of the genus Asterostigma Sp of the family Myrtaceae in an amount representing from 0.05 to 20 % MA by weight of the total weight of the composition and preferably in an amount representing from 0.1 to 5% by weight of the total weight of the composition.  6. Dermatological composition, characterized in that it comprises at least one cell extract from at least one plant of the genus Asterostigma Sp of the family Myrtaceae in a dermatologically acceptable medium.  7. Dermatological composition according to claim 6, characterized in that the Asterostigma Sp extract is an extract of stem cells, bark or leaves.  8. dermatological composition according to claim 6 or 7, characterized in that it comprises an extract of cells of at least one plant of the genus Asterostigma Sp of the family Myrtaceae in an amount representing from 0.05 to 30% MA by weight of the total weight of the composition and preferential in a quantity <Desc / Clms Page number 19>  representing from 0.1 to 10% M.A. by weight of the total weight of the composition.  9. Composition according to any one of claims 3 to 6, characterized in that it further comprises fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers silicones, anti-foam agents, moisturizing agents, vitamins, perfumes, preservatives, surfactants, fillers, sequestering agents, polymers, propellants, alkalizing or acidifying agents, perfumes, dyes, pigments, thickeners, or any other adjuvant usually used in cosmetics or dermatology.  10. Composition according to any one of claims 3 to 9, characterized in that it also comprises at least one agent different from the extracts according to claims 1 or 2, selected from the agents decreasing the differentiation and / or proliferation and / or skin pigmentation, antibacterials, antiparasitics, antifungals, anti-inflammatory agents, anesthetic agents, antipruritic agents, keratolytic agents, anti-free radical agents, antiseborrhics and inhibitors of 5- (x -reductase, anti-acne, deodorant active and antiperspirant active.  11. Composition according to any one of claims 3 to 10, characterized in that the cosmetically or dermatologically acceptable medium consists of water or a mixture of water and lower alcohols or glycols and their ethers.  12. Composition according to any one of claims 3 to 11, characterized in that it is in the form of an aqueous solution, alcoholic or aqueous-alcoholic, a lotion, a cream, a fluid gel, thick cream, powder and is distributed in aerosol spray, pump bottle or roll-on, tube or stick form.  13. Composition according to any one of claims 3 to 12, characterized in that it is in the form of water-in-oil emulsion, oil-in-water, triple emulsion water-in-oil-water . <Desc / Clms Page number 20>  14. Use of an extract according to claim 1 or 2 as a deodorant or antiperspirant active.  15. Use of an extract according to claim 1 or 2, as inhibiting agent for the development of odors.  16. Use of an extract according to claim 1 or 2 as a preservative.  17. Use of an extract according to claim 1 or 2, as an active ingredient for the cosmetic treatment of hyperseborrhoea and / or acne, or as an active ingredient for the cosmetic treatment of scalp conditions.  18. Use of an extract according to claim 1 or 2 in a cosmetic or dermatological composition for limiting microbial growth.  19. Use of an extract as defined in claim 1 or 2 for the preparation of a cosmetic or dermatological composition for treating hyperseborrhoea and / or acne.  20. Use of an extract according to claim 1 or 2 for the preparation of a cosmetic or dermatological composition for treating scalp conditions.  21. Use of an extract according to claim 1 or 2 for the preparation of a composition for oral hygiene.  22. Use of a composition according to any one of claims 3 to 13, as a deodorant composition and / or antiperspirant.  23. Use of a composition according to any one of claims 3 to 13, as an oral composition and preferably as a dentifrice composition.  24. A method for treating human axillary odors, comprising applying to the axillary surface an effective amount of a cosmetic composition according to any one of claims 3 to 5 and 9 to 13.  25. A method of cosmetic treatment of the skin, superficial body growth or scalp, characterized in that it consists in applying to the skin, the integuments or the scalp, a cosmetic composition as defined in any one of the 3 to 5 and 9 to 13, to leave it in contact, and possibly to rinse.