FR2798066A1 - Cosmetic or dermatological composition useful as a preservative, deodorant or anti-acne agent contains extract of cells of Horsfieldia majuscula and tolerated, broad spectrum antimicrobial agent - Google Patents

Abstract

Use of an extract (I) of cells of at least one plant of genus Horsfieldia majuscula (King) (Myristicaceae family) as an antimicrobial agent in cosmetic or dermatological compositions. Independent claims are included for cosmetic or dermatological compositions containing (I).

Description

<Desc / Clms Page number 1>

 An antimicrobial agent based on Horsfieldia Majuscula extract (King) and its use in a dermatological or cosmetic composition.

 The present invention relates to the use of an extract of Horsfieldia Majuscula (King) as an antimicrobial agent, a cosmetic or dermatological composition comprising this antimicrobial agent, the use of this antimicrobial agent as a natural, active preservative for the treatment of hyperseborrhea and / or acne or scalp conditions, and as a deodorant active.

 It is common to introduce into the cosmetic or dermatological compositions antimicrobial agents.

Indeed, these antimicrobial agents are especially intended to prevent the development and proliferation of microorganisms in these compositions Such development of microorganisms would quickly render these compositions unfit for use. To avoid this development, it is necessary to protect the compositions both against the microorganisms that can develop inside the compositions and against those that the user can introduce into them by manipulating them, in particular when gripping the products with the fingers.

The most commonly used chemical preservatives as the antimicrobial agent include C1-C4 alkyl parahydroxybenzoates, or formalin donors. Unfortunately, these preservatives have either the disadvantage of being ineffective against strains that are increasingly resistant, or to cause intolerance on human skin, such as irritation and / or allergies, and more particularly on sensitive skins
Furthermore, it is known to use preservatives in skin-cleaning products such as benzalkonium chloride, chloroacetamide or thimerosal. Thus, WO-A-94/27436 teaches a preservative system comprising a paraben and a quaternary ammonium compound such as benzalkonium chloride or cetylpyridinium chloride. However, the current trend and the

<Desc / Clms Page number 2>

 related legislation, evolve more and more towards the suppression of these compounds because they are not completely devoid of toxicity or undesirable effects.

 Finally, natural preservatives of vegetable origin have often proved to be little or totally ineffective with respect to yeasts and molds.

 It is therefore found that there remains the need for preservatives having an action at least as effective as those of the preservatives of the prior art but not presenting their disadvantages by being in particular non-irritating to the skin or the scalp.

 On the other hand, cutaneous bacterial flora is involved, as is well known, in inflammatory skin conditions such as acne, scalp conditions or seborrheic dermatitis.

 Antimicrobial agents are also used to inhibit or regulate the development of cutaneous bacterial flora, this skin flora degrading including sweat and thus causing the formation of malodorous volatile products.

 The bactericidal substances used so far to reduce or even eliminate axillary odors generally unpleasant, inhibit the development of cutaneous bacterial flora responsible for these axillary odors.

Among these bactericidal products, the most commonly used is Triclosan (5-chloro-2- (2,4-dichlorophenoxy) phenol), which has the disadvantage of significantly modifying the ecology of cutaneous bacterial flora. be inhibited by certain compounds, for example the nonionic surfactants commonly used in the formulation of cosmetic compositions. In addition, the insoluble nature of Triclosan in water does not allow its incorporation into essentially aqueous formulas.

 In order to obtain long-term efficiency, we are therefore looking for new products exercising an action

<Desc / Clms Page number 3>

 deodorant active, that is to say products that are able to modify, reduce and / or remove or prevent the development of body odor (this definition is given in the book "Cosmetic Science and Technology" Series "- 1988 / Volume 7 Chapter 10 - Illc). In addition, we seek products that do not have the disadvantages of the active substances used in the prior art.

 Similarly, active agents used to treat hyperseborrhoea and / or acne or scalp conditions used up to now can cause undesirable effects, including irritation of the skin or the skin. scalp. Thus, it seeks assets for the treatment of hyperseborrhoea and / or acne or scalp conditions, effective, and do not have these disadvantages.

 After much research on the subject, the Applicant has surprisingly discovered that extracts of Horsfieldia Majuscula (King) could be used as an antimicrobial agent.

In particular, it has been noted, for the first time, that this antimicrobial agent has a broad spectrum of antimicrobial activity, in particular with regard to yeasts and molds.

 It has also been observed that these Horsfieldia Majuscula extracts can be used as a natural preservative and as active agents for the prevention or treatment of hyperseborrhoea and / or acne or scalp conditions. Indeed, it has been found that the compositions in accordance with the invention make it possible not only to obtain a rapid improvement of the inflammatory acne state, but also to lead to the reduction of so-called first-type lesions with a non-inflammatory characteristic, just as to get an improvement of the scalp conditions.

These extracts thus have the particular property of preventing the development of bad odors, without the disadvantages of the active substances previously used in the deodorant compositions.

<Desc / Clms Page number 4>

 Extracts of Horsfieldia Majuscula (King) can still be used in oral compositions; these extracts may especially be used as natural preservatives both in anhydrous oral compositions and in aqueous oral compositions.

 The antibacterial agents of the invention also have the advantage of being water-soluble in interesting amounts and sufficient to be easily formulated, especially in water-based cosmetic compositions for human topical application.

 These compositions are furthermore non-toxic and non-irritating.

Subsequently, the term "extract of Horsfieldia Majuscula (King)" shall be understood as "extract of cells of Horsfieldia Majuscula (King)" and more specifically as "extract of cells of at least one plant of the genus Horsfieldia Majuscula (King) of the family Myristicaceae ". Said material can be obtained by in vitro or in vivo culture
By in vitro culture is meant all of the techniques known to those skilled in the art that artificially allow the production of a plant or part of a plant.

 In vivo culture means all the cultivation techniques for obtaining a plant or part of a plant.

 Thus, for example, according to the invention, the extract may be an organ extract (seed or leaf), or even organ cells, of at least one plant of the genus Horsfieldia Majuscula (King) from the family of Myristicaceae, or an undifferentiated cell extract from at least one such plant.

 By undifferentiated plant cells is meant any plant cell having none of the characters of a particular specialization and capable of living on its own and not dependent on other cells. These undifferentiated plant cells are possibly suitable, under

<Desc / Clms Page number 5>

 the effect of induction, to any differentiation according to their genome.

 Depending on the culture method chosen, and in particular depending on the culture medium chosen, it is possible to obtain from the same explant undifferentiated plant cells having different characters.

 The extracts of the invention are in particular purified extracts.

 Any method of purification or extraction known to those skilled in the art can be used according to the invention.

 Mention may in particular be made of alcoholic extracts, in particular ethanolic extracts and hydroalcoholic extracts.

 Thus, in a first step, the plant material is crushed in a cold ethanolic solution, in a second step the suspended particles are removed from the ethanolic solution resulting from the first step, and in a third step the ethanolic solution resulting from the second step. The ethanolic dry extract obtained is then taken up in ethyl acetate, and the new dry extract obtained from ethyl acetate is fractionated by thick layer chromatography.

 On the other hand, the first step can advantageously be replaced by a simple freezing operation of the plant tissues (for example at -20 ° C.), followed by an ethanolic extraction using the steps described above.

 The sonification method described by E. A. MAGEL and Co. 1991. TreesTome 5-203-207 can also be used.

 The invention therefore firstly relates to the use of an extract of Horsfieldia Majuscula (King) of the Myristicaceae family as an antimicrobial agent in dermatological or cosmetic compositions.

 A second subject of the invention consists of a cosmetic or dermatological composition comprising such an extract.

 Another subject of the invention is the use of this extract as a natural, active preservative for the cosmetic treatment of hyperseborrhoea and / or acne, or

<Desc / Clms Page number 6>

 active ingredient for the cosmetic treatment of scalp conditions, active deodorant, antiperspirant active agent, inhibitor of odor development.

 The invention also relates to the use of an extract according to the invention for the preparation of a dermatological or cosmetic composition for treating hyperseborrhoea and / or acne, or scalp conditions.

 The invention also relates to the use of an extract according to the invention for the preparation of a composition for oral hygiene.

 The invention also relates to cosmetic treatment methods using these compositions.

 The essential subject of the present invention is the use of an extract of cells from at least one plant of the genus Horsfieldia Majuscula (King) of the Myristicaceae family as an antimicrobial agent in cosmetic or dermatological compositions.

 The extract of Horsfieldia Majuscula may especially be an extract of seed cells or leaves of Horsfieldia Majuscula.

 The present invention also relates to a cosmetic composition comprising at least one extract as defined above in a cosmetically acceptable medium.

 This cosmetic composition may comprise the extract in an amount representing from 0.05 to 20% by weight of the total weight of the composition and preferably in an amount representing from 0.1 to 5% by weight of the total weight of the composition. .

 The present invention also relates to a dermatological composition comprising at least one extract as defined above in a dermatologically acceptable medium.

 This dermatological composition may comprise an extract in an amount representing from 0.01 to 30% by weight of the total weight of the composition and preferably in an amount representing from 0.05 to 10% by weight of the total weight of the composition.

 The cosmetic or dermatological compositions of the invention may furthermore comprise, depending on the applications

<Desc / Clms Page number 7>

 for which they are intended, adjuvants chosen from fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, silicones, anti-foam agents, moisturizing agents, vitamins , perfumes, surfactants, fillers, sequestering agents, polymers, propellants, alkalizing or acidifying agents, perfumes, dyes, pigments, thickening agents, or any other adjuvant usually used in cosmetics or dermatology.

 The surfactants are preferably chosen from anionic surfactants, in particular alkyl sulphates and alkyl ether sulphates, amphoteric in particular betaines and imidazoline or nonionic derivatives, and in particular those derived from sugar.

 The fatty substances may consist of an oil or a wax or a mixture thereof, petroleum jelly, paraffin, lanolin, hydrogenated lanolin or acetylated lanolin; they also include fatty acids, fatty alcohols such as lauryl, cetyl, myristic, stearic, palmitic, oleic alcohol as well as 2-octyldodecanol, fatty acid esters such as glycerol monostearate, polyethylene glycol monostearate. , isopropyl myristate, isopropyl adipate, isopropyl palmitate, octyl palmitate, C12-C15 fatty alcohol benzoates (Finestein FINETEX TN), polyoxypropylene 3-myristyl alcohol moles of propylene oxide (WITCONOL APM from WITCO), triglycerides of C6-C18 fatty acids such as caprylic / capric acid triglycerides.

 The oils are chosen from animal, vegetable, mineral or synthetic oils and in particular hydrogenated palm oil, hydrogenated castor oil, liquid petrolatum, paraffin oil, purcellin oil (octanoate stearyl), silicone oils and isoparaffins.

 The waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. These include beeswax, carnauba wax, candelilla wax, sugar cane, japan, ozokerites, wax

<Desc / Clms Page number 8>

 of Montan, microcrystalline waxes, paraffins, waxes and silicone resins.

 The thickeners, preferably nonionic, may be selected from guar gums and modified or unmodified celluloses such as hydroxypropyl guar gum, cetylhydroxyethylcellulose, silicas such as Bentone Gel MiO sold by NL INDUSTRIES or Veegum Ultra, sold by the company POLYPLASTIC.

The compositions of the invention may comprise emollients, which contribute to a soft, dry, non-sticky feel when the composition is applied to the skin. These emollients can be chosen from products of the volatile silicone type, non-silicone silicones and volatile and other non-volatile emollients. Generally the emollients are present in proportions ranging from 20 to 80%, preferably from 25 to 60% and even more preferably from 35 to 55%.
Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type whose chains comprise from 3 to 9 silicone residues. The cyclomethicones D4 or D5 are preferably chosen.

 Nonvolatile silicones are defined in a known manner as compounds with low vapor pressure at ambient temperature. Among these compounds are polyalkylsiloxanes, in particular linear polyalkylsiloxanes, for example linear polydimethylsiloxanes, or dimethicones, marketed by Dow Corning under the name Dow Corning 200 Fluid; polyalkylarylsiloxanes, for example polymethylphenylsiloxanes, sold by Dow Corning under the name Dow Corning 556 Fluid; polyether and siloxane copolymers, for example dimethicone copolyols.

 Among the non-volatile emollients that may be used in the present invention, there may be mentioned, for example: hydrocarbon derivatives, mineral oils, fatty alcohols,

<Desc / Clms Page number 9>

 esters of C3-C18 alcohols with C3-C18 acids, esters of benzoic acid with C12-C18 alcohols and mixtures thereof, C2-C6 polyols preferably chosen from glycerol, propylene glycol or sorbitol, polymers of polalkylene glycol.

 According to the invention, the cosmetic and dermatological compositions may associate with the extracts according to the invention, other active agents.

Among these active agents, there may be mentioned by way of example: other active agents of plant origin capable of reinforcing the antimicrobial activity, and in particular among them the extract of Sorbus aucuparia, the extract of Melaleuca alternifolia, extract of Asparagopsis armata, bamboo extract, oil extracted from Eucalyptus globulus, oil extracted from Pinus silvestry, oil extracted from Tea Tree; agents which decrease the differentiation and / or proliferation and / or cutaneous pigmentation such as retinoic acid and its isomers, retinol and its esters, vitamin
D and its derivatives, estrogens such as estradiol, kojic acid or hydroquinone; antibacterials such as clindamycin phosphate, erythromycin or antibiotics of the tetracycline class; antiparasitics, in particular metronidazole, crotamiton or pyrethrinoids; antifungals, in particular with anti-dandruff action, in particular compounds belonging to the class of imidazoles such as econazole, ketoconazole or miconazole or their salts, polyene compounds, such as amphotericin B, compounds of the family of allylamines, such as terbinafine, or octopirox or zinc pyrithione; steroidal anti-inflammatory agents, such as hydrocortisone, betamethasone valerate or clobetasol propionate, or non-steroidal anti-inflammatory agents such as, for example, ibuprofen and its salts,

<Desc / Clms Page number 10>

 diclofenac and its salts, acetylsalicylic acid, acetaminophen or glycyrrhizic acid; anesthetic agents such as lidocaine hydrochloride and its derivatives; antipruritic agents such as thenaldine, trimeprazine or cyproheptadine; keratolytic agents such as α- and s-hydroxycarboxylic acids or α-ketocarboxylic acids, their salts, amides or esters and more particularly hydroxy acids such as glycolic acid, lactic acid, salicylic acid, citric acid and generally fruit acids, and n-octanoyl-5-salicylic acid; anti-free radical agents, such as atocopherol or its esters, superoxide dismutases, certain metal chelators or ascorbic acid and its esters; antiseborrhoeic agents and 5-a-reductase inhibitors; anti-acne drugs such as retinoic acid or benzoyl peroxide; - deodorant assets; and- antiperspirant actives.

 To the above list, other compounds may also be added, namely for example diazoxide, spiroxazone, phospholipids such as lecithin, linoleic and linolenic acids and their esters, lactones and their corresponding salts, anthralin, carotenoids, eicosatetraenoic and eicosatrienoic acids or their esters and amides, vitamin D and its derivatives, extracts of plant or bacterial origin.

 The deodorant active agents may be chosen for example from: water-soluble zinc salts, for example zinc pyrrolidone carboxylate (more commonly known as zinc pidolate), zinc sulphate, zinc chloride, zinc lactate, gluconate zinc and zinc phenolsulfonate Antiperspirant actives may be aluminum salts, such as aluminum chloride and aluminum hydroxyhalides; zirconium salts, such as, for example, zirconium oxide salts, hydroxyzirconyl salts; metal complexes like

<Desc / Clms Page number 11>

 aluminum or zirconium with an amino acid such as for example glycine as described in US Pat. No. 3,792,068.

 The dermatologically or cosmetically acceptable medium may especially consist of water or mixtures of water and solvents such as lower alcohols such as ethanol or isopropanol, ethylene glycol, propylene glycol, dipropylene glycol and their ethers.

 The compositions according to the invention may be ingested or applied to the skin (on any cutaneous zone of the body), the hair, the nails or the mucous membranes (buccal, jugal, gingival, genital, conjunctival). Depending on the mode of administration, the composition according to the invention may be in any of the galenical forms normally used.

 The compositions according to the invention may especially be in the form of aqueous, alcoholic or aqueous-alcoholic solutions, lotions, creams or fluid gels, thick creams, powders and may be dispensed in aerosol spray, in a pump bottle or in rolls. or in the form of a stick and contain in this respect the ingredients and propellants generally used in this type of products and well known to those skilled in the art, provided that they do not interfere with the antimicrobial agents described in the present invention.

 The compositions according to the invention can also be formulated in water-in-oil, oil-in-water or triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C FOX in "Cosmetics and Toiletries" November 1986, Vol 101, pages 101-112), in which case the antimicrobial agent is present in the aqueous phase of the emulsion, or may be encapsulated.

 The compositions according to the invention can thus be used as deodorant cosmetic or dermatological compositions, but also as hair care compositions, and especially a shampoo, styling lotions, treatment lotions, styling creams or gels, dye compositions (especially dyeing compositions). oxidation) optionally in the form of coloring shampoos, as lotions

<Desc / Clms Page number 12>

 Restructuring for the hair, compositions of perm (including a composition for the first time of a permanent), antiparasitic shampoos, etc.

 The composition according to the invention may also be for oral use, preferably a toothpaste, and more preferably still a mouthwash. In this case, the composition may contain adjuvants and additives customary for oral compositions and in particular for toothpastes, surfactants, thickeners, humectants, polishing agents such as silica, various active ingredients such as fluorides, in particular sodium fluoride, and possibly sweetening agents such as sodium saccharin.

 The amounts of the various constituents of the compositions according to the invention are those conventionally used in the fields under consideration.

 The compositions according to the invention may also consist of liquid or solid preparations constituting soaps, solid preparations constituting cleaning loaves or liquid preparations for sanitizing the skin and disinfecting the hands.

 When the composition is an emulsion, the proportion of the fatty phase can range from 5% to 80% by weight and preferably from 5% to 50% by weight relative to the total weight of the composition. The oils, the waxes, the emulsifiers and the coemulsifiers used in the composition in emulsion form are chosen from those conventionally used in the cosmetics field. The emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition. The emulsion may further contain lipid vesicles.

 When the composition is a solution or an oily gel, the fatty phase may represent more than 90% of the total weight of the composition.

<Desc / Clms Page number 13>

 The cosmetic or dermatological compositions of the present invention are formulated conventionally according to the applications for which they are intended.

 Another subject of the invention is the use of a composition according to the invention as a deodorant and / or antiperspirant composition.

 Another subject of the invention is also the use of an extract according to the invention for the preparation of a composition for oral hygiene, that is to say a composition intended in particular to restore and / or or to maintain the good condition of the oral cavity.

 Another subject of the invention also relates to the use of a composition as defined above as an oral-dental composition, preferably as a dentifrice composition and even more preferentially as a mouthwash.

 Another object of the invention is a cosmetic process for treating human axillary odors, comprising applying to the axillary surface an effective amount of a cosmetic composition according to the invention.

 Another method according to the invention relates to a cosmetic or dermatological treatment of the skin, superficial body growths or scalp, consisting in applying to these, a cosmetic or dermatological composition as defined above, to leave the latter in contact, and possibly rinsing.

 The cosmetic treatment methods of the invention may be implemented in particular by applying the cosmetic compositions defined above, according to the usual techniques of use of these compositions. For example: application of creams, gels, lotions, milks on the skin.

 The following examples and compositions illustrate the invention without limiting it in any way.

<Desc / Clms Page number 14>

EXAMPLES
Example 1 Preparation of an Horsfieldia extract
Majuscula (King) Horsfieldia Majuscula (King) seeds of the Myristicaceae family from Malaysia (Cameron Highlands) were used.

Fractionation was carried out by drying and grinding the seed into a powder of about 0.25 to 0.5 mm milling.

This powder was extracted by ethanol depletion: the powder was covered with enough ethanol, stirred, filtered and / or centrifuged three times; the filtrates and / or the supernatants were evaporated to dryness. 1.14 g of the ethanolic dry extract obtained with ethyl acetate was taken up. After filtration and drying, 404.8 mg of the dry extract obtained from ethyl acetate were chromatographed on a thick layer with the eluting solvent being a mixture of methylene chloride / methanol (90/10 by volume). ). Three bands were then eluted with a mixture of methylene chloride / methanol.

After drying, three fractions were obtained, the determination of the antimicrobial activity of the largest (202.8 mg) is shown in Example 2 below. Example 2: Determination of the antimicrobial activity The antimicrobial activity of the dry extract obtained in the example
1 was determined by a conventional method called MIC (Minimum Inhibitory Concentration), the MIC corresponding to the lowest concentration at which a given product inhibits the growth of a given strain under defined conditions.

In this case, referenced strains distributed by the
Collection Service of the Pasteur Institute of Paris (CIP) were used: Staphylococcus aureus CIP 4. 83

<Desc / Clms Page number 15>

Pseudomonas aeruginosa CIP 105094, Candida albicans CIP 48. 72, Corynebacterium xerosis CIP 5216, Aspergillus niger IIP 218.

The tests were carried out on extracts, namely the powder obtained in Example 1, at 5% in ethanol. 100 ml of the solution were added to 1.9 ml of 45 C supercooled agar culture medium ( medium chosen according to the nutritional requirements of the studied strain). After vortex stirring, successive dilutions, in geometric progression of reason 2, of the solution obtained were carried out using the agar culture medium in supercooling at 45 ° C. 1 ml of each dilution was introduced into the wells. a microplate (Falcon, 24 wells). 4 ml of microbial suspension were deposited on the surface of the agar medium.

A control tube was also prepared ethanol or H20
100 ml + 1.9 ml of culture medium.

The concentration of the antimicrobial agent from which the growth of the microorganism is completely inhibited (absence of environmental disorder) is thus determined
RESULTS

<Tb>
<tb> MIC <SEP> (mg / ml)
<tb> S. <SEP> aureus <SEP> P. <SEP> aeruginosa <SEP> C <SEP> xerosis <SEP> C. <SEP> albicans <SEP> A. <SEP> niger
<tb> (gram <SEP> +) <SEP> (gram-) <SEP> (gram +) <SEP> (yeast) <SEP> (mold)
<tb> 4.5 <SEP> 10-2 <SEP> 9.0 <SEP> 10-2 <SEP> 4.5 <SEP> 10-2 <SEP> 2.2 <SEP> 10-2 <SEP > 4.5 <SEP> 10-2
<Tb>

Claims (24)

1. Use of an extract of cells of at least one plant of the genus Horsfieldia Majuscula (King) from the family Myristicaceae as an antimicrobial agent in cosmetic or dermatological compositions.  2. Use according to claim 1, characterized in that the extract of Horsfieldia Majuscula is an extract of seed cells or leaves.  3. Cosmetic composition characterized in that it comprises at least one extract of cells from at least one plant of the genus Horsfieldia Majuscula (King) of the family Myristicaceae in a cosmetically acceptable medium.  4. Cosmetic composition according to claim 3, characterized in that the extract of Horsfieldia Majuscula is an extract of seed cells or leaves.  5. Cosmetic composition according to claim 3 or 4, characterized in that it comprises at least one extract of cells of at least one plant of the genus Horsfieldia Majuscula of the family Myristicaceae in an amount representing 0.05 at 20% by weight of the total weight of the composition and preferably in an amount representing from 0.1 to 5% by weight of the total weight of the composition.  6. Dermatological composition, characterized in that it comprises at least one cell extract of at least one plant of the genus Horsfieldia Majuscula (King) of the family Myristicaceae in a dermatologically acceptable medium.  7. dermatological composition according to claim 6, characterized in that the extract of Horsfieldia Majuscula is an extract of seed cells or leaves 8. dermatological composition according to claim 6 or 7, characterized in that it comprises an extract of cells of at least one plant of the genus Horsfieldia Majuscula of the family Myristicaceae in an amount representing from 0.01 to 30% MA by weight of the total weight of the composition and preferential in a quantity <Desc / Clms Page number 17>  representing from 0.05 to 10% M.A. by weight of the total weight of the composition.  9. Composition according to any one of claims 3 to 5, characterized in that it further comprises fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers silicones, antifoaming agents, moisturizing agents, vitamins, perfumes, surfactants, fillers, sequestering agents, polymers, propellants, alkalizing or acidifying agents, perfumes, dyes, pigments, agents thickeners, or any other adjuvant usually used in cosmetics or dermatology.  10. Composition according to any one of claims 3 to 9, characterized in that it also comprises at least one agent differing from the extracts according to claims 1 or 2, selected from plant-based active ingredients enhancing the antimicrobial activity. extracts according to claims 1 or 2, the agents reducing differentiation and / or proliferation and / or skin pigmentation, antibacterials, antiparasitics, antifungals, anti-inflammatory agents, anesthetic agents, antipruritic agents, anti-inflammatory agents, keratolytic agents, anti-free radical agents, antiseborrhics and 5-a-reductase inhibitors, anti-acne drugs, deodorant active agents and antiperspirant active agents.  11. Composition according to any one of claims 3 to 10, characterized in that the cosmetically or dermatologically acceptable medium consists of water or a mixture of water and lower alcohols or glycols and their ethers.  12. Composition according to any one of claims 3 to 11, characterized in that it is in the form of an aqueous solution, alcoholic or aqueous-alcoholic, a lotion, a cream, a fluid gel, thick cream, powder and is distributed in aerosol spray, pump bottle or roll-on, tube or stick form.  13. Composition according to any one of <Desc / Clms Page number 18>  Claims 3 to 12, characterized in that it is in the form of a water-in-oil, oil-in-water emulsion, triple water-in-oil-in-water emulsion, or in encapsulated form.  14. Use of an extract according to claim 1 or 2, as a natural preservative.  15. Use of an extract according to claim 1 or 2, as an active ingredient for the cosmetic treatment of hyperseborrhoea and / or acne, or as an active ingredient for the cosmetic treatment of scalp conditions.  16. Use of an extract according to claim 1 or 2 as a deodorant or antiperspirant active.  17. Use of an extract according to claim 1 or 2, as an inhibitor of odor development.  18. Use of an extract as defined in claim 1 or 2 for the preparation of a cosmetic or dermatological composition for treating hyperseborrhoea and / or acne.  19. Use of an extract according to claim 1 or 2 for the preparation of a cosmetic or dermatological composition for treating scalp conditions.  20. Use of an extract according to claim 1 or 2 for the preparation of a composition for oral hygiene.  21. Use of a composition according to any one of claims 3 to 13, as a deodorant composition and / or antiperspirant.  22. Use of a composition according to any one of claims 3 to 13, as an oral-dental composition, preferably as a dentifrice composition and more preferably as a mouthwash.  23. A method for treating human axillary odors, comprising applying to the axillary surface an effective amount of a cosmetic composition according to any one of claims 3 to 5 and 9 to 13.  24. A method of cosmetic treatment of the skin, superficial body growths or scalp, characterized in that <Desc / Clms Page number 19>  consists in applying to the skin, the integuments or the scalp, a cosmetic composition as defined in any one of claims 3 to 5 and 9 to 13, to leave it in contact, and possibly to rinse.