FR2831059A1 - Topical compositions for treating greasy and acneic skin comprise a fructo-oligosaccharide - Google Patents

Topical compositions for treating greasy and acneic skin comprise a fructo-oligosaccharide Download PDF

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FR2831059A1
FR2831059A1 FR0113464A FR0113464A FR2831059A1 FR 2831059 A1 FR2831059 A1 FR 2831059A1 FR 0113464 A FR0113464 A FR 0113464A FR 0113464 A FR0113464 A FR 0113464A FR 2831059 A1 FR2831059 A1 FR 2831059A1
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fructo
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FR2831059B1 (en
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Jean Noel Thorel
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Abstract

Cosmetic and pharmaceutical compositions for topical use comprise a fructo-oligosaccharide (I) in a physiologically-acceptable medium. Cosmetic and pharmaceutical compositions for topical use comprise a fructo-oligosaccharide (I) in a physiologically-acceptable medium. (I) comprises: (1) alpha-D-glucopyranosyl-(1,1)-alpha-D-fructofuranosyl-(2,1)-alpha-D-fru ctofuranoside; (2) alpha-D-glucopyranosyl-(1,1)-alpha-D-fructofuranosyl-(2,1)-alpha-D-fru ctofuranosyl-(2,1)-alpha-D-fructofuranoside; and (3) alpha-D-glucopyranosyl-(1,1)-alpha-D-fructofuranosyl-(2,1)-alpha-D-fru ctofuranosyl-(2,1)-alpha-D-fructofuranosyl-(2,1)-alpha-D-fructofuranos ide.

Description

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La présente invention a trait à l'utilisation de fructo-oligosaccharides (FOS) comme matière première utilisable dans des compositions cosmétiques, pharmaceutiques ou dermatologiques, comme agent séborégulateur et/ou comme agent conservateur, notamment destiné à une application topique pour peaux sensibles.  The present invention relates to the use of fructo-oligosaccharides (FOS) as a raw material that can be used in cosmetic, pharmaceutical or dermatological compositions, as a sebum-regulating agent and / or as a preservative, in particular intended for topical application for sensitive skin.

Les fructo-oligosacharrides employés dans le cadre de la présente invention répondent à la formule suivante (1) :

Figure img00010001
The fructo-oligosaccharides employed in the context of the present invention correspond to the following formula (1):
Figure img00010001

Figure img00010002

Avec : GlucoseFructose=
Figure img00010003

Les fructo-oligosaccharides utilisés dans le cadre de la présente invention sont connus, notamment dans le domaine diététique (Drevon T., omet F., Les fructo-oligosaccharides, Actilighf&commat;' ; Le sucre, les sucres, les édulcorants et les glucides de charge dans les I. A. A. ; Tec et Doc lavoisier Eds, 1992, 12, 313-38) pour leurs propriétés prébiotique, ou encore pour leur application comme fibres
Figure img00010002

With: GlucoseFructose =
Figure img00010003

The fructo-oligosaccharides used in the context of the present invention are known, particularly in the dietary field (Drevon T., omet F., fructooligosaccharides, Actilighf &commat;'Sugar, sugars, sweeteners and carbohydrates. load in the IAA, Tec and Doc Lavoisier Eds, 1992, 12, 313-38) for their prebiotic properties, or for their application as fibers

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alimentaires hydrosolubles (Alamowitch C. et Ail, Les glucides : origine, structure, effets nutritionnels, ; cah Nulr Diét, 1995, 6, 396-400).  water-soluble diets (Alamowitch C. and Garlic, Carbohydrates: origin, structure, nutritional effects, Nulr Diét, 1995, 6, 396-400).

Il est courant d'introduire dans les compositions à usage topique, des conservateurs chimiques destinés à lutter contre le développement des microorganismes dans ces compositions, ce qui les rendraient rapidement inaptes à l'utilisation. Il faut notamment protéger les compositions contre les microorganismes susceptibles de se développer à l'intérieur de la composition et également contre ceux que l'utilisateur pourrait y introduire en la manipulant, en particulier lors de la préhension avec les doigts de produits en pot.  It is common to introduce into the compositions for topical use, chemical preservatives for combating the development of microorganisms in these compositions, which would render them quickly unsuitable for use. In particular, it is necessary to protect the compositions against the microorganisms that can develop inside the composition and also against those that the user could introduce by manipulating it, in particular during the gripping with the fingers of potted products.

Des conservateurs chimiques couramment utilisés sont notamment les parabènes ou les composes libérateurs de formol. Ces conservateurs présentent toutefois l'inconvénient de causer des irritations, en particulier sur les peaux sensibles, lorsqu'ils sont présents à des taux relativement importants. Comme autres conservateurs connus, on peut citer les hydroxyacides organiques. Mais ces composés peuvent également générer des irritations du fait de leur effet desquamant sur la peau.  Commonly used chemical preservatives include parabens or formalin-releasing compounds. These preservatives, however, have the disadvantage of causing irritation, especially on sensitive skin, when they are present at relatively high rates. Other known preservatives include organic hydroxy acids. But these compounds can also cause irritation because of their desquamating effect on the skin.

Il subsiste donc le besoin d'agents conservateurs, notamment d'agents anti-microbiens, ayant une action au moins aussi efficace que les composés de l'art antérieur, mais n'en présentant pas les inconvénients.  There therefore remains the need for preservatives, especially antimicrobial agents, having an action at least as effective as the compounds of the prior art, but without the disadvantages.

Ainsi, un objet de la présente invention est donc l'utilisation de fructooligosaccharides répondant à la formule (1) telle que définie ci-dessus, comme agent conservateur.  Thus, an object of the present invention is therefore the use of fructooligosaccharides corresponding to formula (1) as defined above, as a preservative.

Un autre objet de l'invention est un procédé de conservation d'une composition cosmétique ou pharmaceutique, caractérisé en ce qu'il consiste à incorporer dans ladite composition des fructo-oligosaccharides de formule (1) tel que défini ci-dessus.  Another subject of the invention is a method for preserving a cosmetic or pharmaceutical composition, characterized in that it consists in incorporating into said composition fructo-oligosaccharides of formula (1) as defined above.

Un autre objet de l'invention est une composition cosmétique ou pharmaceutique, comprenant, dans un milieu physiologiquement acceptable, des fructo-oligosaccharides de formule (1) selon l'invention, en tant qu'agent de traitement des peaux grasses et acnéiques.  Another subject of the invention is a cosmetic or pharmaceutical composition, comprising, in a physiologically acceptable medium, fructooligosaccharides of formula (1) according to the invention, as a treatment agent for oily and acneic skin.

On a donc constaté que, de manière surprenante et inattendue, ces fructooligosaccharides présentaient de bonnes propriétés anti-microbiennes, que cela soit vis-à-vis des bactéries, des levures ou des champignons/moisissures. De par  It has thus been found that, surprisingly and unexpectedly, these fructooligosaccharides have good antimicrobial properties, whether against bacteria, yeasts or fungi / molds. By

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leur spectre anti-microbien, ces composés peuvent donc être employés, notamment dans les compositions cosmétiques, comme seuls agents antimicrobiens, notamment comme agents anti-bactériens, comme agents antilevures et/ou comme agents anti fongiques.  their anti-microbial spectrum, these compounds can therefore be used, especially in cosmetic compositions, as sole antimicrobial agents, especially as anti-bacterial agents, as antilevide agents and / or as anti-fungal agents.

Ces fructo-oligosaccharides peuvent être employés de manière avantageuse dans les compositions cosmétiques ou pharmaceutiques, notamment dermatologiques, en tant qu'agent conservateur en association avec les conservateurs autorisés par la législation en vigueur.  These fructo-oligosaccharides may advantageously be used in cosmetic or pharmaceutical compositions, especially dermatological compositions, as a preserving agent in combination with the preservatives authorized by the legislation in force.

De manière surprenante et inattendue, ces fructo-oligosaccharides présentent également de bonnes propriétés sur le traitement des peaux grasses, en particulier sur l'amélioration de la quantité de sébum et plus particulièrement encore sur la diminution des boutons d'acné.  Surprisingly and unexpectedly, these fructo-oligosaccharides also have good properties on the treatment of oily skin, in particular on the improvement of the amount of sebum and more particularly on the reduction of acne pimples.

Par ailleurs, les composés selon l'invention du fait de leur structure chimique clairement définie et caractérisée, sont aisément reproductibles et leur fabrication industrielle est aisée.  Furthermore, the compounds according to the invention because of their clearly defined and characterized chemical structure are easily reproducible and their industrial manufacture is easy.

De plus, ils possèdent une bonne solubilité ou compatibilité avec les milieux couramment employés en cosmétique, les milieux aqueux notamment.  In addition, they have good solubility or compatibility with media commonly used in cosmetics, including aqueous media.

De manière avantageuse, la tolérance des produits topiques ainsi fabriqués est grandement améliorée. En effet l'un des inconvénients majeur des produits actifs sur les micro-organismes responsables de l'acné est la mauvaise tolérance cutanée. Il se trouve que dans le cadre de l'invention, les produits sont efficaces sans être irritants pour la muqueuse cutanée.  Advantageously, the tolerance of the topical products thus manufactured is greatly improved. Indeed, one of the major drawbacks of the active products on the micro-organisms responsible for acne is poor skin tolerance. It is found that in the context of the invention, the products are effective without being irritating to the cutaneous mucosa.

Les fructo-oligosaccharides sont être présents dans les compositions cosmétiques ou pharmaceutiques en particulier dermocosmétiques, en une quantité suffisante pour obtenir l'effet recherché, comprise entre 0,01 et 30% en poids, de préférence entre 0,01 et 15% en poids, et plus particulièrement entre 0,5 et 5% en poids, par rapport au poids total de la composition.  The fructo-oligosaccharides are present in cosmetic or pharmaceutical compositions, in particular dermocosmetic compositions, in an amount sufficient to obtain the desired effect, of between 0.01 and 30% by weight, preferably between 0.01 and 15% by weight. , and more particularly between 0.5 and 5% by weight, relative to the total weight of the composition.

Les compositions comprenant lesdits fructo-oligosaccharides comprennent un milieu cosmétiquement ou pharmaceutiquement acceptable, c'est-à-dire compatible avec la peau, les muqueuses, les cheveux et le cuir chevelu. Elles peuvent se présenter sous toutes les formes galéniques appropriées pour une application topique, notamment sous forme de solution aqueuse, hydroalcoolique, organique ou huileuse ; de suspension ou de dispersion dans des solvants ou des  Compositions comprising said fructo-oligosaccharides comprise a cosmetically or pharmaceutically acceptable medium, that is to say, compatible with the skin, the mucous membranes, the hair and the scalp. They may be in any of the galenic forms suitable for topical application, especially in the form of aqueous, hydroalcoholic, organic or oily solution; suspension or dispersion in solvents or

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corps gras, de type lotion ou sérum ; sous forme de dispersion vésiculaire ; sous forme d'émulsion E/H, H/E ou multiple telle qu'une crème ou un lait ; sous forme de pommade, de gel, de bâtonnet solide, de produits anhydres pâteux ou solides, de mousse notamment aérosol ou de spray.  fat, lotion or serum type; as a vesicular dispersion; in the form of W / O, O / W or multiple emulsion such as cream or milk; in the form of ointment, gel, solid stick, anhydrous pasty or solid products, foam, especially aerosol or spray.

Le milieu physiologiquement acceptable dans lequel les composés peuvent être employés, ainsi que ses constituants, leur quantité, la forme galénique de la composition et son mode de préparation, peuvent être choisis par l'homme du métier sur la base de ses connaissances générales en fonction du type de composition recherchée.  The physiologically acceptable medium in which the compounds may be employed, as well as its constituents, their quantity, the galenic form of the composition and its method of preparation, may be chosen by those skilled in the art on the basis of their general knowledge in function the type of composition sought.

Notamment, la composition peut comprendre tout corps gras usuellement utilisé dans le domaine d'application envisagé. On peut notamment citer les corps gras siliconés tels que les huiles, les gommes et les cires de silicone, ainsi que les corps gras non siliconés tels que les huiles et les cires d'origine végétale, minérale, animale et/ou synthétique. Les huiles peuvent éventuellement être volatiles ou non volatiles. On peut encore citer les hydrocarbures, les esters et les éthers de synthèse, les alcools gras et les acides gras. La composition peut également comprendre un milieu aqueux, un milieu hydro-alcoolique contenant un alcool tel que l'éthanol ou l'isopropanol, ou un milieu organique comprenant des solvants organiques usuels tels que des alcools en Cri-6, notamment l'éthanol et l'isopropanol, des glycols tels que le propylène glycol, des cétones.  In particular, the composition may comprise any fatty substance usually used in the intended field of application. Mention may in particular be made of silicone fatty substances such as oils, gums and silicone waxes, as well as non-silicone fatty substances such as oils and waxes of vegetable, mineral, animal and / or synthetic origin. The oils may optionally be volatile or non-volatile. Mention may also be made of hydrocarbons, esters and synthetic ethers, fatty alcohols and fatty acids. The composition may also comprise an aqueous medium, an alcohol-alcoholic medium containing an alcohol such as ethanol or isopropanol, or an organic medium comprising common organic solvents such as C 6 -6 alcohols, in particular ethanol and isopropanol, glycols such as propylene glycol, ketones.

La composition peut comprendre au moins un émulsionnant classique, choisi parmi les émulsionnants amphotères, anioniques, cationiques ou non ioniques, utilisés seuls ou en mélange.  The composition may comprise at least one conventional emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture.

Elle peut également comprendre les adjuvants habituels dans le domaine considéré, tels que les épaississants ou gélifiants hydrophiles ou lipophiles, les additifs hydrophiles ou lipophiles, les actifs notamment cosmétiques, les conservateurs, les antioxydants, les parfums, les charges, les pigments, les filtres UV, les absorbeurs d'odeur, les colorants, les hydratants (glycérine), des vitamines, des acides gras essentiels, des polymères liposolubles notamment hydrocarbonés, les opacifiants, les stabilisants, les séquestrants, les conditionneurs, les agents propulseurs.  It may also comprise the usual adjuvants in the field under consideration, such as hydrophilic or lipophilic thickeners or gelling agents, hydrophilic or lipophilic additives, especially cosmetic actives, preservatives, antioxidants, perfumes, fillers, pigments, filters. UV, odor absorbers, dyes, moisturizers (glycerine), vitamins, essential fatty acids, liposoluble polymers including hydrocarbon, opacifiers, stabilizers, sequestering agents, conditioners, propellants.

Bien entendu l'homme du métier veillera à choisir ce ou ces éventuels adjuvants complémentaires et/ou leur quantité de manière telle que les propriétés  Of course, those skilled in the art will take care to choose this or these optional additional adjuvants and / or their quantity in such a way that the properties

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avantageuses de la composition selon l'invention ne soient pas, ou substantiellement pas, altérées par l'adjonction envisagée.  of the composition according to the invention are not, or not substantially impaired by the addition envisaged.

Les fructo-oligosaccharides employés dans le cadre de la présente invention présentent donc une activité anti-microbienne, notamment une activité anti-bactérienne et anti-fongique, remarquable, ils trouvent donc une application toute particulière dans des compositions pouvant se présenter : - sous la forme d'un produit de maquillage de la peau du visage, du corps ou des lèvres, tel qu'un fond de teint, un fard à joues ou à paupières, un stick anti-cernes, un stick camouflant, un eye-liner, un mascara, un rouge à lèvres, un vernis à ongles, un soin des ongles, - sous la forme d'un produit de soin dermatologique ou cosmétique de la peau du visage, du corps y compris le cuir chevelu, des lèvres, tel qu'une base de

Figure img00050001

soin pour les lèvres, une base fixante à appliquer sur un rouge à lèvres classique, une composition de protection solaire ou de bronzage artificiel ; un produit déodorant ; une composition de soin (de jour, de nuit, anti-rides, hydratante, etc.) pour le visage ; une composition matifiante pour le visage ; un gel ou une crème de nettoyage ou de démaquillage ; un lait corporel de protection ou de soin ; un lait purifiant, - sous la forme d'une composition désodorisante ; d'un gel ou lotion aprèsrasage ; d'une crème dépilatoire, - sous la forme d'une composition pharmaceutique, - sous la forme d'une composition solide telle qu'un savon ou un pain de nettoyage, - sous la forme d'une composition pour aérosol comprenant également un agent propulseur sous pression, - sous la forme d'une composition pour soins capillaires, et notamment un shampooing, une lotion de mise en plis, une lotion traitante, une crème ou un gel coiffant, une composition de teinture (notamment d'oxydation) éventuellement sous forme de shampooing colorant, de lotion restructurante pour cheveux, une composition pour permanente, une lotion ou un gel antichute, un shampooing antiparasitaire ; une lotion ou un shampooing antipelliculaire ; un shampooing traitant notamment anti-séborrhéique, The fructo-oligosaccharides employed in the context of the present invention thus have an antimicrobial activity, especially an antibacterial and anti-fungal activity, which is remarkable, they therefore find a very particular application in compositions which may be: form of a makeup product for the skin of the face, body or lips, such as a foundation, a blush or an eyeshadow, a concealer stick, a camouflaging stick, an eyeliner, a mascara, a lipstick, a nail polish, a nail care, - in the form of a dermatological or cosmetic care product for the skin of the face, the body including the scalp, the lips, such as a base of
Figure img00050001

lip care, a fixing base to be applied to a conventional lipstick, a sunscreen or artificial tanning composition; a deodorant product; a care composition (day, night, anti-wrinkle, moisturizing, etc.) for the face; a mattifying composition for the face; a gel or a cream for cleaning or removing make-up; body milk for protection or care; a purifying milk, in the form of a deodorizing composition; a gel or lotion after shaving; a depilatory cream, - in the form of a pharmaceutical composition, - in the form of a solid composition such as a soap or a cleaning cake, - in the form of an aerosol composition also comprising an agent propellant under pressure, in the form of a composition for hair care, and in particular a shampoo, a setting lotion, a treatment lotion, a cream or a styling gel, a dyeing composition (in particular oxidation) in the form of a coloring shampoo, a restructuring hair lotion, a permanent composition, a lotion or an anti-hair loss gel, a pest control shampoo; an anti-dandruff lotion or shampoo; a shampoo treating in particular anti-seborrheic,

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- sous la forme d'une composition à usage bucco-dentaire, par exemple une pâte dentifrice.  in the form of a composition for oral use, for example a toothpaste.

La présente invention est illustrée plus en détails dans les exemples suivants.  The present invention is further illustrated in the following examples.

Exemple 1 : crème de soin

Figure img00060001
Example 1: care cream
Figure img00060001

<tb>
<tb> - <SEP> tristéarate <SEP> de <SEP> sorbitane <SEP> 1 <SEP> %
<tb> - <SEP> fructo-oligosaccharides <SEP> 15 <SEP> %
<tb> - <SEP> homopolymère <SEP> carboxyvinylique <SEP> 0,4 <SEP> %
<tb> - <SEP> gomme <SEP> de <SEP> xanthane <SEP> 0,5 <SEP> %
<tb> - <SEP> copolymère <SEP> diméthacrylate
<tb> d'éthylèneglycol/méthacrylate <SEP> de <SEP> lauryle <SEP> 1 <SEP> %
<tb> - <SEP> cyclopentadiméthylsiloxane <SEP> 6 <SEP> %
<tb> - <SEP> glycérine <SEP> 3 <SEP> %
<tb> - <SEP> émulsionnant <SEP> 4 <SEP> %
<tb> - <SEP> parfum <SEP> qsp
<tb> - <SEP> eau <SEP> déminéralisée <SEP> qsp <SEP> 100%
<tb> Exemple <SEP> 2 <SEP> : <SEP> lotion
<tb> - <SEP> fructo-oligosaccharides <SEP> (Actilight&commat;) <SEP> 2 <SEP> %
<tb> - <SEP> glycérine <SEP> 2
<tb> - <SEP> alcool <SEP> éthylique <SEP> 2 <SEP> %
<tb> - <SEP> Cétrimide <SEP> BP <SEP> 0. <SEP> 4 <SEP> %
<tb> - <SEP> butanol <SEP> oxyéthyléné <SEP> (26OE) <SEP> oxypropyléné <SEP> (260P),
<tb> huile <SEP> de <SEP> ricin <SEP> hydrogénée <SEP> oxyéthylénée <SEP> (40 <SEP> OE) <SEP> dans <SEP> l'eau <SEP> 1 <SEP> %
<tb> - <SEP> eau <SEP> déminéralisée <SEP> qsp <SEP> 100%
<tb> <Tb>
<tb> - <SEP> tristearate <SEP> of <SEP> sorbitan <SEP> 1 <SEP>%
<tb> - <SEP> fructooligosaccharides <SEP> 15 <SEP>%
<tb> - <SEP> homopolymer <SEP> carboxyvinyl <SEP> 0.4 <SEP>%
<tb> - <SEP> gum <SEP> of <SEP> xanthan <SEP> 0.5 <SEP>%
<tb> - <SEP> copolymer <SEP> dimethacrylate
<tb> ethylene glycol / methacrylate <SEP> of <SEP> lauryl <SEP> 1 <SEP>%
<tb> - <SEP> cyclopentadimethylsiloxane <SEP> 6 <SEP>%
<tb> - <SEP> glycerin <SEP> 3 <SEP>%
<tb> - <SEP> emulsifier <SEP> 4 <SEP>%
<tb> - <SEP> perfume <SEP> qs
<tb> - <SEP> water <SEP> demineralized <SEP> qsp <SEP> 100%
<tb> Example <SEP> 2 <SEP>: <SEP> lotion
<tb> - <SEP> fructooligosaccharides <SEP> (Actilight &commat;)<SEP> 2 <SEP>%
<tb> - <SEP> Glycerin <SEP> 2
<tb> - <SEP> alcohol <SEP> ethyl <SEP> 2 <SEP>%
<tb> - <SEP> Cetrimide <SEP> BP <SEP> 0. <SEP> 4 <SEP>%
<tb> - <SEP> butanol <SEP> oxyethylenated <SEP> (26OE) <SEP> oxypropylenated <SEP> (260P),
<tb> oil <SEP> of <SEP> ricin <SEP> hydrogenated <SEP> oxyethylenated <SEP> (40 <SE>SE)>SEP> in <SEP> water <SEP> 1 <SEP>%
<tb> - <SEP> water <SEP> demineralized <SEP> qsp <SEP> 100%
<Tb>

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Exemple 3 : Crème de traitement des peaux qrasses

Figure img00070001
Example 3 Cream of treatment of skins qrasses
Figure img00070001

<tb>
<tb> - <SEP> fructo-oligosaccharides <SEP> 4 <SEP> %
<tb> - <SEP> glycérine <SEP> 2 <SEP> %
<tb> - <SEP> Cétrimide <SEP> BP <SEP> 0. <SEP> 4 <SEP> %
<tb> - <SEP> Sulfate <SEP> de <SEP> Zinc <SEP> 0.05 <SEP> %
<tb> - <SEP> Gluconate <SEP> de <SEP> Zinc <SEP> 0.1 <SEP> %
<tb> -Vitamine <SEP> B6 <SEP> 0.01 <SEP> %
<tb> - <SEP> Salcare&commat;91 <SEP> 1%
<tb> - <SEP> eau <SEP> déminéralisée <SEP> qsp <SEP> 100%
<tb> <Tb>
<tb> - <SEP> fructooligosaccharides <SEP> 4 <SEP>%
<tb> - <SEP> glycerin <SEP> 2 <SEP>%
<tb> - <SEP> Cetrimide <SEP> BP <SEP> 0. <SEP> 4 <SEP>%
<tb> - <SEP> Sulfate <SEP> of <SEP> Zinc <SEP> 0.05 <SEP>%
<tb> - <SEP> Gluconate <SEP> of <SEP> Zinc <SEP> 0.1 <SEP>%
<tb> -Vitamin <SEP> B6 <SEP> 0.01 <SEP>%
<tb> - <SEP> Salcare &commat; 91 <SEP> 1%
<tb> - <SEP> water <SEP> demineralized <SEP> qsp <SEP> 100%
<Tb>

Claims (8)

Figure img00080001
Figure img00080001
Figure img00080002
Figure img00080002
 REVENDICATIONS 1. Composition cosmétique ou pharmaceutique, à usage topique comprenant dans un milieu physiologiquement acceptable au moins un fructooligosaccharide répondant à la formule suivante : 1. Cosmetic or pharmaceutical composition for topical use comprising in a physiologically acceptable medium at least one fructooligosaccharide corresponding to the following formula: Avec : Gtucose-psGlucose= U Fructose =  With: Gtucose-psGlucose = U Fructose =
Figure img00080003
Figure img00080003
 <Desc/Clms Page number 9> <Desc / Clms Page number 9> 2. Composition selon la revendication 1, caractérisée en ce que le fructooligosaccharide est présent dans la composition cosmétique ou pharmaceutique en une quantité comprise entre 0,001 et 30% en poids, de préférence entre 0,01 et 15% en poids, et plus particulièrement entre 0,5 et 5% en poids, par rapport au poids total de la composition. 2. Composition according to claim 1, characterized in that the fructooligosaccharide is present in the cosmetic or pharmaceutical composition in an amount of between 0.001 and 30% by weight, preferably between 0.01 and 15% by weight, and more particularly between 0.5 and 5% by weight, relative to the total weight of the composition. 3. Utilisation de fructo-oligosaccharides de formule (1) :  3. Use of fructo-oligosaccharides of formula (1):
Figure img00090001
Figure img00090001
 comme agent anti-microbien, comme agent anti-bactérien, comme agent anti- levure et/ou comme agent anti-fongique pour la formulation de compositions destinées à améliorer la flore microbienne de la peau.  as an anti-microbial agent, as an anti-bacterial agent, as an anti-yeast agent and / or as an anti-fungal agent for the formulation of compositions for improving the microbial flora of the skin.
Figure img00090003
Figure img00090003
 Avec : Glucose- ! Fructose= 9  With: Glucose-! Fructose = 9
Figure img00090002
Figure img00090002
 4. Utilisation selon la revendication 3 pour la formulation de compositions destinées au traitement des peaux grasses et/ou acnéiques.  4. Use according to claim 3 for the formulation of compositions for the treatment of oily and / or acneic skin. <Desc/Clms Page number 10> <Desc / Clms Page number 10>
Figure img00100001
Figure img00100001
 5. Utilisation de fructo-oligosaccharides de formule (1)  5. Use of fructo-oligosaccharides of formula (1)
Figure img00100002
Figure img00100002
 comme agent conservateur dans la formulation de compositions cosmétiques.  as a preservative in the formulation of cosmetic compositions.
Figure img00100004
Figure img00100004
 Avec : Glucose = t z Fructose=  With: Glucose = t z Fructose =
Figure img00100003
Figure img00100003
 6. Utilisation selon la revendication 5 pour la formulation de compositions cosmétiques à tolérance améliorée, qui comprennent en outre des conservateurs autorisés par la législation dans des proportions inférieures aux proportions habituelles.  6. Use according to claim 5 for the formulation of cosmetic compositions with improved tolerance, which further comprise preservatives authorized by the legislation in proportions lower than the usual proportions. <Desc/Clms Page number 11> <Desc / Clms Page number 11> 7. Procédé d'amélioration de la stabilité d'une composition cosmétique ou pharmaceutique, caractérisé en ce qu'il consiste à incorporer dans ladite composition au moins un fructo-oligosaccharide de formule (1)  7. Process for improving the stability of a cosmetic or pharmaceutical composition, characterized in that it consists in incorporating into said composition at least one fructo-oligosaccharide of formula (1)
Figure img00110001
Figure img00110001
 Avec : Glucose = Fructose  With: Glucose = Fructose
Figure img00110002
Figure img00110002
 <Desc/Clms Page number 12> <Desc / Clms Page number 12> 8. Agent conservateur caractérisé en ce qu'il comprend à titre de principe actif au moins un fructo-oligosaccharide de formule (1) 8. Preservative agent characterized in that it comprises as active ingredient at least one fructo-oligosaccharide of formula (1)
Figure img00120001
Figure img00120001
 Avec : Glucose = Fructose = With: Glucose = Fructose =
Figure img00120002
Figure img00120002
FR0113464A 2001-10-18 2001-10-18 USE OF FRUCTO-OLIGOSACCHARIDES AS COSMETIC ACTIVE INGREDIENTS, COMPOSITIONS COMPRISING SAME AND METHOD OF CONSERVATION USING THE SAME Expired - Lifetime FR2831059B1 (en)

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FR2954140A1 (en) * 2009-12-17 2011-06-24 Oreal COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS
WO2020065213A1 (en) * 2018-09-28 2020-04-02 Laboratoires De Biologie Vegetale Yves Rocher Use of an agave extract for enhancing the barrier function of the skin, scalp and/or mucusa and modulating the skin microbiota
EP4019015A1 (en) 2020-12-24 2022-06-29 NAOS Institute of Life Science Cosmetic composition capable of reinforcing epidermal tight junctions for the prevention and/or treatment of atopic dermatitis
FR3118711A1 (en) * 2021-01-12 2022-07-15 Beghin Meiji COSMETIC METHOD AND COMPOSITION BASED ON SHORT CHAIN FRUCTO-OLIGOSACCHARIDES
WO2022152762A1 (en) * 2021-01-12 2022-07-21 Beghin Meiji Cosmetic method and composition based on short-chain fructooligosaccharides and a native starch
FR3129083A1 (en) * 2021-11-18 2023-05-19 Beghin Meiji COSMETIC METHOD AND COMPOSITION BASED ON SHORT CHAIN FRUCTO-OLIGOSACCHARIDES

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2954140A1 (en) * 2009-12-17 2011-06-24 Oreal COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS
WO2011073437A3 (en) * 2009-12-17 2012-08-23 L'oreal Bacteriocin- and prebiotic-based cosmetic or dermatological compositions
WO2020065213A1 (en) * 2018-09-28 2020-04-02 Laboratoires De Biologie Vegetale Yves Rocher Use of an agave extract for enhancing the barrier function of the skin, scalp and/or mucusa and modulating the skin microbiota
FR3086542A1 (en) * 2018-09-28 2020-04-03 Laboratoires De Biologie Vegetale Yves Rocher USE OF AN AGAVE EXTRACT TO STRENGTHEN THE BARRIER FUNCTION OF THE SKIN, SCALP AND / OR MUCOSUS AND MODULATE THE CUTANEOUS MICROBIOTE
EP4019015A1 (en) 2020-12-24 2022-06-29 NAOS Institute of Life Science Cosmetic composition capable of reinforcing epidermal tight junctions for the prevention and/or treatment of atopic dermatitis
FR3118416A1 (en) 2020-12-24 2022-07-01 Naos Institute Of Life Science COSMETIC COMPOSITION SUITABLE FOR REINFORCING TIGHT EPIDERMAL JUNCTIONS FOR THE PREVENTION AND/OR TREATMENT OF ATOPIC DERMATITIS
US11617708B2 (en) 2020-12-24 2023-04-04 Jean-Noël Thorel Cosmetic composition capable of strengthening epidermal tight junctions for the prevention and/or treatment of atopic dermatitis
FR3118711A1 (en) * 2021-01-12 2022-07-15 Beghin Meiji COSMETIC METHOD AND COMPOSITION BASED ON SHORT CHAIN FRUCTO-OLIGOSACCHARIDES
WO2022152762A1 (en) * 2021-01-12 2022-07-21 Beghin Meiji Cosmetic method and composition based on short-chain fructooligosaccharides and a native starch
FR3129083A1 (en) * 2021-11-18 2023-05-19 Beghin Meiji COSMETIC METHOD AND COMPOSITION BASED ON SHORT CHAIN FRUCTO-OLIGOSACCHARIDES

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