EP1268526A4 - Molecules d'acide nucleique specifiques de la prostate ou des testicules, polypeptides, techniques de diagnostic, et traitement therapeutique - Google Patents
Molecules d'acide nucleique specifiques de la prostate ou des testicules, polypeptides, techniques de diagnostic, et traitement therapeutiqueInfo
- Publication number
- EP1268526A4 EP1268526A4 EP01922630A EP01922630A EP1268526A4 EP 1268526 A4 EP1268526 A4 EP 1268526A4 EP 01922630 A EP01922630 A EP 01922630A EP 01922630 A EP01922630 A EP 01922630A EP 1268526 A4 EP1268526 A4 EP 1268526A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- specific
- testis
- polypeptides
- diagnostic
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 210000002307 prostate Anatomy 0.000 title 1
- 210000001550 testis Anatomy 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19192900P | 2000-03-24 | 2000-03-24 | |
US191929P | 2000-03-24 | ||
PCT/US2001/009410 WO2001072962A2 (fr) | 2000-03-24 | 2001-03-23 | Molecules d'acide nucleique specifiques de la prostate ou des testicules, polypeptides, techniques de diagnostic, et traitement therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1268526A2 EP1268526A2 (fr) | 2003-01-02 |
EP1268526A4 true EP1268526A4 (fr) | 2004-09-08 |
Family
ID=22707491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01922630A Withdrawn EP1268526A4 (fr) | 2000-03-24 | 2001-03-23 | Molecules d'acide nucleique specifiques de la prostate ou des testicules, polypeptides, techniques de diagnostic, et traitement therapeutique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1268526A4 (fr) |
JP (1) | JP2004521602A (fr) |
AU (2) | AU2001249411B2 (fr) |
CA (1) | CA2403637A1 (fr) |
WO (1) | WO2001072962A2 (fr) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
DK1086223T3 (da) | 1998-06-01 | 2009-11-30 | Agensys Inc | Nye serpentintransmembranantigener udtrykt i humane cancerformer og anvendelser deraf |
US20040141975A1 (en) | 1998-06-01 | 2004-07-22 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
US20060052321A1 (en) | 2002-04-05 | 2006-03-09 | Raitano Arthur B | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
US20040048798A1 (en) * | 1999-06-01 | 2004-03-11 | Raitano Arthur B. | Nucleic acid and corresponding protein entitle 98P4B6 useful in treatment and detection of cancer |
US6835812B1 (en) | 1999-04-29 | 2004-12-28 | University Of Tennessee Research Corporation | Human p-Hyde proteins |
EP1328151A4 (fr) * | 1999-04-29 | 2004-06-16 | Univ Tennessee Res Corp | Acides nucleiques isoles de la famille p-hyde, proteines p-hyde et procede pour induire la susceptibilite a l'induction de la mort cellulaire programmee pendant le cancer |
US7611892B2 (en) | 2000-03-24 | 2009-11-03 | President And Fellows Of Harvard College | Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
GB2379660A (en) * | 2001-01-30 | 2003-03-19 | Aeomica Inc | Human GTP-Rho binding protein 2 |
EP1231216A3 (fr) * | 2001-01-30 | 2004-03-17 | Aeomica, Inc. | Protéine humaine qui se lie au gtp-rho |
US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
EP2287186B1 (fr) | 2001-09-06 | 2014-12-31 | Agensys, Inc. | Acide nucléique et protéine corréspondante designés par STEAP-1 utiles dans le traitement et la détection du cancer |
JP2005534287A (ja) * | 2002-04-05 | 2005-11-17 | アジェンシス, インコーポレイテッド | 癌の処置および検出において有用な98p4b6との名称の核酸および対応するタンパク質 |
JP5840351B2 (ja) * | 2002-09-06 | 2016-01-06 | アジェンシス,インコーポレイテッド | 癌の処置および検出において有用な98p4b6と称される、核酸および対応タンパク質 |
EP1725249B1 (fr) | 2003-11-06 | 2014-01-08 | Seattle Genetics, Inc. | Composes de monomethylvaline capables de conjugaison aux ligands |
GB0326834D0 (en) * | 2003-11-18 | 2003-12-24 | Celltech R&D Ltd | A protein involved in lung cancer |
TWI238677B (en) | 2003-12-25 | 2005-08-21 | Fujitsu Ltd | Organic EL element, organic EL display, process for fabricating organic EL element, and device for fabricating organic EL element |
US8008442B2 (en) | 2004-04-22 | 2011-08-30 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
JP5234734B2 (ja) | 2004-06-01 | 2013-07-10 | ジェネンテック, インコーポレイテッド | 抗体−薬物結合体および方法 |
ES2669510T3 (es) | 2004-09-23 | 2018-05-28 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
AU2005246090A1 (en) * | 2005-02-22 | 2005-12-01 | Biomedisinsk Innovasjon As | STAMP2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
RU2483080C2 (ru) | 2006-10-27 | 2013-05-27 | Дженентек, Инк. | Антитела и иммуноконъюгаты и их применение |
EP2292089A1 (fr) * | 2008-01-11 | 2011-03-09 | Astellas Pharma Inc. | Modèle animal ayant à la fois une douleur dans les testicules ou des actions d'inconfort en relation aux testicules et une miction fréquente |
IN2012DN03025A (fr) | 2009-09-09 | 2015-07-31 | Ct Se Llc | |
EA024730B1 (ru) | 2010-04-15 | 2016-10-31 | Медимьюн Лимитед | Пирролбензодиазепиновые соединения, их конъюгаты, фармацевтические композиции, содержащие указанные конъюгаты, и применение указанных конъюгатов |
US9000130B2 (en) | 2010-06-08 | 2015-04-07 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
JP5889912B2 (ja) | 2010-11-17 | 2016-03-22 | ジェネンテック, インコーポレイテッド | アラニニルメイタンシノール抗体コンジュゲート |
CA2833212C (fr) | 2011-05-12 | 2020-06-09 | Genentech, Inc. | Reaction multiple de surveillance du procede lc-ms/ms pour detecter les anticorps therapeutiques dans les echantillons d'animaux par des peptides de signature du cadre |
ES2556584T3 (es) | 2011-10-14 | 2016-01-19 | Medimmune Limited | Pirrolobenzodiazepinas y conjugados de las mismas |
WO2013130093A1 (fr) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline |
PT2766048E (pt) | 2012-10-12 | 2015-02-25 | Spirogen Sarl | Pirrolobenzodiazepinas e conjugados das mesmas |
EP2906250B1 (fr) | 2012-10-12 | 2018-05-30 | ADC Therapeutics SA | Conjugués pyrrolobenzodiazepine-anticorps anti-psma |
NZ707543A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
ES2649990T3 (es) | 2012-10-12 | 2018-01-16 | Medimmune Limited | Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas |
ES2660029T3 (es) | 2012-10-12 | 2018-03-20 | Medimmune Limited | Conjugados de anticuerpo-pirrolobenzodiazepinas |
KR101995619B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
SI2906253T1 (sl) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin-protitelo proti PSMA |
WO2014096365A1 (fr) | 2012-12-21 | 2014-06-26 | Spirogen Sàrl | Dimères de pyrrolobenzodiazépines asymétriques à utiliser dans le traitement de maladies prolifératives et auto-immunes |
WO2014096368A1 (fr) | 2012-12-21 | 2014-06-26 | Spirogen Sàrl | Pyrrolobenzodiazépines et conjugués associés |
US9649390B2 (en) | 2013-03-13 | 2017-05-16 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
CN105209077B (zh) | 2013-03-13 | 2019-06-11 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓以及其结合物 |
EP2968596B1 (fr) | 2013-03-13 | 2019-03-06 | Medimmune Limited | Pyrrolobenzodiazépines et leurs conjugués |
CA2918139A1 (fr) | 2013-08-12 | 2015-02-19 | Genentech, Inc. | Conjugues anticorps-medicament dimerique 1-(chloromethyl)-2,3-dihydro-1 h-benzo [e]indole, et methodes d'utilisation et de traitement |
EP3054983B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépines |
WO2015052535A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
WO2015052534A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
JP6671292B2 (ja) | 2013-12-16 | 2020-03-25 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
CR20160271A (es) | 2013-12-16 | 2016-12-02 | Genentech Inc | Compuestos peptidométicos y sus conjugados de anticuerpo-fármaco |
MX2016007578A (es) | 2013-12-16 | 2016-10-03 | Genentech Inc | Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento. |
WO2016037644A1 (fr) | 2014-09-10 | 2016-03-17 | Medimmune Limited | Pyrrolobenzodiazépines et leurs conjugués |
CA2957354A1 (fr) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anticorps et conjugues modifies genetiquement avec de la cysteine |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
WO2016040825A1 (fr) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés |
US20160074527A1 (en) | 2014-09-17 | 2016-03-17 | Genentech, Inc. | Pyrrolobenzodiazepines and antibody disulfide conjugates thereof |
US10780096B2 (en) | 2014-11-25 | 2020-09-22 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
MX2017007169A (es) | 2014-12-03 | 2018-05-02 | Genentech Inc | Compuestos de amina cuaternaria y conjugados de anticuerpofármaco de los mismos. |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
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GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
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GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
EP3465221B1 (fr) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Procédé bioanalytique pour la caractérisation de conjugués anticorps-médicament spécifiques d'un site |
JP7043425B2 (ja) | 2016-06-06 | 2022-03-29 | ジェネンテック, インコーポレイテッド | シルベストロール抗体-薬物コンジュゲート及び使用方法 |
EP3496763A1 (fr) | 2016-08-11 | 2019-06-19 | Genentech, Inc. | Promédicaments de pyrrolobenzodiazépine et conjugués d'anticorps de ceux-ci |
JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
JP6671555B2 (ja) | 2017-02-08 | 2020-03-25 | アーデーセー セラピューティクス ソシエテ アノニム | ピロロベンゾジアゼピン抗体複合体 |
WO2018184966A1 (fr) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Anticorps se liant à steap-1 |
WO2018192944A1 (fr) | 2017-04-18 | 2018-10-25 | Medimmune Limited | Conjugués de pyrrolobenzodiazépine |
EP3612234B1 (fr) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Polythérapie avec un conjugué anticorps anti-axl-médicament |
JP7145891B2 (ja) | 2017-06-14 | 2022-10-03 | アーデーセー セラピューティクス ソシエテ アノニム | 抗cd19 adcを投与するための投与レジメ |
EA039276B1 (ru) | 2017-08-18 | 2021-12-27 | Медимьюн Лимитед | Пирролобензодиазепиновые конъюгаты |
BR112020004307A2 (pt) | 2017-09-20 | 2020-11-10 | Ph Pharma Co., Ltd. | análogos de tailanestatina |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
AU2019365238A1 (en) | 2018-10-24 | 2021-05-13 | F. Hoffmann-La Roche Ag | Conjugated chemical inducers of degradation and methods of use |
JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック, インコーポレイテッド | Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
AR128331A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpos y métodos de estos |
AR128330A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpo y métodos de estos |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999062941A2 (fr) * | 1998-06-01 | 1999-12-09 | Urogenesys, Inc. | Nouveaux antigenes transmembranaires du type serpentin exprimes dans des cancers humains et utilisation de ces antigenes |
WO2000073509A2 (fr) * | 1999-06-01 | 2000-12-07 | Incyte Genomics, Inc. | Molecules utilisees a des fins diagnostiques et therapeutiques |
WO2001005970A2 (fr) * | 1999-07-19 | 2001-01-25 | Incyte Genomics, Inc. | Proteines associees de liaison gtp |
Family Cites Families (3)
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US5599686A (en) * | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
US5820880A (en) * | 1995-06-07 | 1998-10-13 | The United States Of America As Represented By The Secretary Of The Army | Liposomal formulation |
US6048970A (en) * | 1998-05-22 | 2000-04-11 | Incyte Pharmaceuticals, Inc. | Prostate growth-associated membrane proteins |
-
2001
- 2001-03-23 WO PCT/US2001/009410 patent/WO2001072962A2/fr active IP Right Grant
- 2001-03-23 CA CA002403637A patent/CA2403637A1/fr not_active Abandoned
- 2001-03-23 AU AU2001249411A patent/AU2001249411B2/en not_active Ceased
- 2001-03-23 EP EP01922630A patent/EP1268526A4/fr not_active Withdrawn
- 2001-03-23 JP JP2001571877A patent/JP2004521602A/ja not_active Withdrawn
- 2001-03-23 AU AU4941101A patent/AU4941101A/xx active Pending
Patent Citations (3)
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---|---|---|---|---|
WO1999062941A2 (fr) * | 1998-06-01 | 1999-12-09 | Urogenesys, Inc. | Nouveaux antigenes transmembranaires du type serpentin exprimes dans des cancers humains et utilisation de ces antigenes |
WO2000073509A2 (fr) * | 1999-06-01 | 2000-12-07 | Incyte Genomics, Inc. | Molecules utilisees a des fins diagnostiques et therapeutiques |
WO2001005970A2 (fr) * | 1999-07-19 | 2001-01-25 | Incyte Genomics, Inc. | Proteines associees de liaison gtp |
Non-Patent Citations (6)
Title |
---|
DATABASE EMBL [online] EBI; 10 December 1999 (1999-12-10), EMMANUEL DIAS NETO ET AL: "SHOTGUN SEQUENCING OF THE HUMAN TRANSCRIPTOME WITH ORF EXPRESSED SEQUENCE TAGS", XP002279053, Database accession no. AI908168 * |
DATABASE EMBL [online] EBI; 22 February 2000 (2000-02-22), ISOGAI T., OTSUKI T., XP002241852, Database accession no. AK001691 * |
DATABASE EMBL [online] EBI; 26 April 1999 (1999-04-26), MAHAIRAS G.G ET AL.: "Sequence-tagged connectors...", Database accession no. AQ456610 * |
DIATCHENKO L ET AL: "SUPPRESSION SUBTRACTIVE HYBRIDIZATION: A METHOD FOR GENERATING DIFFERENTIALLY REGULATED OR TISSUE-SPECIFIC CDNA PROBES AND LIBRARIES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 June 1996 (1996-06-01), pages 6025 - 6030, XP002911922, ISSN: 0027-8424 * |
MAHAIRAS G G ET AL: "SEQUENCE-TAGGED CONNECTORS: A SEQUENCE APPROACH TO MAPPING AND SCANNING THE HUMAN GENOME", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 17, AQ456610, August 1999 (1999-08-01), pages 9739 - 9744, XP002175436, ISSN: 0027-8424 * |
WATANABE G ET AL: "PROTEIN KINASE N (PKN) AND PKN-RELATED PROTEIN RHOPHILIN AS TARGETS OF SMALL GTPASE RHO", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 271, no. 5249, 2 February 1996 (1996-02-02), pages 645 - 648, XP001109460, ISSN: 0036-8075 * |
Also Published As
Publication number | Publication date |
---|---|
JP2004521602A (ja) | 2004-07-22 |
WO2001072962A2 (fr) | 2001-10-04 |
AU2001249411B2 (en) | 2007-02-15 |
CA2403637A1 (fr) | 2001-10-04 |
WO2001072962A3 (fr) | 2002-01-17 |
EP1268526A2 (fr) | 2003-01-02 |
AU4941101A (en) | 2001-10-08 |
AU2001249411B9 (en) | 2001-10-08 |
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